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This paper summarized the nursing experience of non-invasive ventilation in prone position for a patient with acute respiratory distress syndrome combined with COVID-19. Key issues in nursing management included nursing assessment in the whole procedure of non-invasive ventilation in prone position, infection prevention, management of body position and tube, skin care, health education and so on. In the early stage of COVID-19 complicated with ARDS, non-invasive ventilation in prone position can not only effectively reduce the tube intubation and improve hypoxemia, but also reduce the labor cost and level of difficulty in nursing, reduce the workload and exposure time of medical staff, and reduce the risk of infection among medical staff. (本文总结1例新型冠状病毒肺炎合并急性呼吸窘迫综合征(ARDS)患者俯卧位无创通气治疗康复的护理经验。护理措施包括俯卧位无创通气全程护理评估、感染预防、体位及管道的管理、皮肤护理、健康宣教等。新型冠状病毒肺炎合并ARDS早期患者在清醒状态下进行无创呼吸机俯卧位通气, 不仅有效减少插管, 改善低氧血症, 同时也可以减轻人力成本和护理难度, 减少医务人员的工作量及暴露时间, 减少医务人员的感染风险。)

Objective To explore the clinical manifestation, pathological features, effective treatment regimen and prognosis of subcutaneous panniculitis-like T cell lymphoma (SPTCL) patients. Methods We analyzed retrospectively the clinicopathologic features, diagnosis and treatment of five SPTCL patients who were confirmed pathologically. Results Atypical lymphocytic infiltration in the subcutaneous adipose tissue was found in all five patients. Tumor cells showed immunophenotype of cytotoxic T lymphocytes. Painless subcutaneous nodules were found in all patients: two patients with fever and one patient with bone marrow infiltration. All patients were in advanced stage(stage Ⅲ-Ⅳ), and four patients were in good condition (ECOG score was 1), two patients with high level of LDH and three patients with high level of β2-MG. Three cases used CHOP for initial treatment, one case used BACOP and one case used BEACOP. Up to now, one case died, one case was lost to visit, and other three cases had complete remission. The median survival time was 44 (3-100) months, and the median progression-free survival time was 8 (0-96) months. Conclusion The incidence of SPTCL is extremely low, mainly involving the subcutaneous adipose tissue. There is no uniform treatment so far. CHOP on advanced patients has poor efficacy. High intensity chemotherapy with etoposide may become the effective treatment.

The main reason causing clay shale formation wellbore instability is that the expansion and sloughing of clay shale after water absorption. The thought was proposed that silicon dioxide nano-particles was used to plug the nano-size pores and throats of shale to reduce the permeability of shale, resulting in decreasing and delaying water invasion into shale. On the basis of preliminary studies, the paper evaluated the improvement effect of three types of drilling mud with two brands of silica nano-particles at different temperature, by means of transmission electron microscopy analysis, regular performance test of drilling fluid and scanning electron microscope analysis. Results show that silica nano-particles could effectively reduce the filtration of Fresh Water Mud (FWM) and Bentonite Mud (BM) with temperature increase. It could reduce the loss of water by 56.25% at room temperature and 78% at 140 ℃. It has little effect on Low Solid Mud (LSM). Finally, to the drilling mud with the weight concentration of 10% had better plugging capacity than that with the weight concentration of 5% because of forming more continuous and tight mud cake. Based on the experiment results, FWM and BM's filtration properties could be improved using nano-particles with temperature increase (from room temperature to 160 ℃). [ABSTRACT FROM AUTHOR]

This paper investigated the relationship between coal rock permeability and heating temperature in less than 200 °C through laboratory experiments. And by means of X-ray diffraction analysis and Scanning Electron Microscope, the influence of heat on coal rock permeability was analyzed from perspective of coal chemistry and coal geology. The results shows that coal rock permeability could be significantly increased from less than 0.5 mD to 15 mD by heat treating. Analyzing results indicate that mechanisms may be explained as follows: Firstly, dehydration of coal rock and partly volatile components releasing of coal rock will form new pores. Secondly, desorption of methane molecules and dehydration of gelatinous micro-component in the matrix lead to the shrinkage of coal matrix. Thirdly, coal rock generates hydrocarbon gases after oxidizing reaction of carbon and Hydrogen atoms, and the gas releasing forms tiny cracks and reduces the degree of coal rock compaction. Fourth, coal rock encounters inhomogeneous deformation under thermal stress, and produces uneven small cracks. Finally, the paper proposes a new mode of coal bed methane (CBM) exploitation to enhance CBM recovery by injecting thermal CO2. Above researches may be of great help to the exploitation of CBM reservoirs with low permeability in China. [ABSTRACT FROM AUTHOR]

Objective: To determine clinical and pathologic profiles for anaplastic large cell lymphoma (ALCL).
 Methods: The clinical data of 22 patients with ALCL were analyzed retrospectively. Therapentie effect of different treatment strategies on ALCL was evaluated.
 Results: The median age for these patients was 32(9-70) years old and the patients with positive ALK accounted for 68.2% (15/22). All patients underwent chemotherapy, including regiments of CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), CHOPE (CHOP plus etoposide) or BEACOP (CHOP plus etoposide and bleomycin). Fourteen (63.6%) patients achieved initial complete remission (CR) and the CR rate for patients with ALK+ was significantly higher than that of patients with ALK- (P<0.05), while the age, gender, stage, beta 2-microglobulin (2-MG) level, lactate dehydrogenase (LDH) level, B symptoms had no significant effect on the rate of CR (P>0.05). After a median follow-up of 41 (2-150) months, 12 patients were overall survival, the median progression free time was 22.5 (2-150) months, and the age, gender, stage, IPI index, ALK expression level, beta 2-MG level, LDH level, and B symptoms had no significant effect on the rate of overall survival (P>0.05).
 Conclusion: ALK-positive occurs mainly in ALCL patients. The chemotherapy is still the main treatment, and CHOPE regimen is a better initial treatment scheme because the most patients show good prognosis.

Objective: To determine whether there are in vivo differences of metabolites levels in bilateral cortical masticatory area(CMA) of patients with sleep bruxism, compared with healthy controls using proton magnetic resonance spectroscopy(1H-MRS). Accordingly to explore if cortical control of the central jaw motor system is abnormal in sleep bruxism patients., Methods: Fifteen sleep bruxism patients and fifteen age- and gender-matched healthy controls underwent 1H-MRS of bilateral CMA using J-difference edited point-resolved spectroscopy sequence(MEGA-PRESS) technique. Levels of metabolites were quantified from the ratio of the metabolite integral to the unsuppressed water signal. Differences of levels of γ-aminobutyric acid(GABA), glutmate(Glu) and N-acetyl aspartate(NAA) in bilateral CMA between sleep bruxism patients and healthy controls were tested using two-way ANOVA., Results: Edited spectra were successfully obtained from the bilateral CMA in all of the participants. Levels of GABA+, glutmate and NAA in right and left CMA in sleep bruxism patients were (2.45±0.48)×10(-3), (2.35±0.62)×10(-3), (10.65±1.84)×10(-3), (10.49±2.37)×10(-3), (10.70±3.61)×10(-3), and (11.26±4.01)×10(-3) respectively. In contrast, levels of GABA+, glutmate and NAA in right and left CMA in healthy controls were (2.63±0.68)×10(-3), (2.65±0.97)×10(-3), (11.19± 1.34)×10(-3), (10.58±3.14)×10(-3), (11.82±1.80)×10(-3), and (11.95±3.23)×10(-3). There were no differences in levels of GABA+(P=0.196), Glu(P=0.590), and NAA(P=0.292) between sleep bruxism patients and healthy controls, nor in inbilateral CMA(GABA+: P=0.837; Glu: P=0.510; NAA: P=0.628)., Conclusions: The results indicate the absence of any alteration of the cortical control of the central jaw motor system in the levels of GABA, Glu and NAA in patients with sleep bruxism.

Objective: To analyze the clinical and pathological features, molecular biological markers and prognosis of primary gastrointestinal diffuse large B-cell lymphoma (DLBCL)., Methods: A retrospective study was conducted in 92 cases of primary gastrointestinal DLBCL. The data of clinical characteristics, pathological and immunohistochemical features were analyzed. The relationship between different factors at diagnosis and prognosis were studied., Results: Of the 92 patients, the male-female ratio was 1.56:1 with a median age of 59(7-89) years. The most frequently involved site was stomach (50.0%), followed by small intestine (15.2%), colon (12.0%), ileocecum (10.9%) and multiple gastrointestinal tract involvements (9.8%). The ratio of non-germinal center B cell (non-GCB) subtype to germinal center B cell (GCB) was 2:1. Among the cases, Ki-67 had a high level expression with a median positive rate >80%. Positive expression of Bcl-2 was detected in 52.1% cases (25/48). Evidence of Helicobacter pylori (Hp) infections was detected in 34.0% cases with stomach involvement. Of the patients, 75 were included in a follow-up study with a median time of 48 months (3-130 months). The complete remission(CR)rate was 66.7%(50/75),the partial remission (PR) rate was 22.7% (17/75) and the overall response rate was 89.4% (67/75). The 1-, 3- and 5- year survival rates of the patients were 85.3%, 66.2% and 60.5%, respectively. The incidence of secondary malignancy after chemotherapy was 2.7%. The multivariate analysis indicated that primary colic DLBCL or multiple involvements of gastrointestinal tract and low serum albumin level (<35 g/L) at diagnosis were independently associated with poor outcome. Patients who received chemotherapy combined with rituximab (43 cases) had a higher CR rate (79.1% vs 46.9%, P=0.008) and 5-year overall survival (77.5% vs 53.1%, P=0.0045) than those without rituximab (32 case)., Conclusion: Primary gastrointestinal DLBCL was a highly invasive and heterogeneous malignancy. In our data, the proportion of non-GCB subtype was higher. Primary colic DLBCL and those with multiple involvements of gastrointestinal tract had poor survival. Low serum albumin at diagnosis indicated poor outcome. Rituximab treatment in addition to chemotherapy might help to improve the clinical outcome. Further prospective trails were needed to confirm our results.

Objective: To investigate the effect of the iron chelator deferoxamine (DFA) in suppressing microglia activation and protecting against secondary neural injury in a rat model of intracerebral hemorrhage (ICH)., Methods: SD rats were randomly divided into sham-operated group, ICH group and DFA treatment group. ICH model was established by infusion of type IV collagenase into the right basal ganglia, and starting from 1 h after the operation, the rats received intraperitoneal DFA injections every 12 h for 7 days. The iron content in the perihematoma brain tissue was determined at different time points after DFA administration, and OX42 immunohistochemistry was used to observe the changes in the microglia. The contents of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in the brain tissue were detected by ELISA. The neural death and neurological deficiency were measured using Nissl staining and neurological scores, respectively., Results: The iron content in the brain tissues around the hematoma was significantly increased 3 days after ICH and maintained a high level till 28 days, accompanied by a marked increase of microglial cells as compared to the sham-operated group. DFA injection caused significantly decreased iron content in the brain tissue, reduced number of microglial cells, and lowered levels of IL-1β and TNF-α. Neuronal loss around the hematoma was obviously reversed after DFA injections, which resulted in improved neurological deficiency., Conclusion: DFA can suppress microglia activation by removing iron overload from the perihematoma brain tissue, thus reducing secondary neuronal death and neurological deficiency in rats with ICH.

Cognitive and emotional dysfunction in depressed patients has been broadly researched. However, the physiological mechanism of the emotional impairment is still obscure. In this study, according to the ethical principles and the procedures of informed consent, we enrolled 16 depression patients and 16 normal subjects in a "learning-judgment" cognitive task. Emotional faces were chosen and used as the visual stimuli, while the subjects' scalp electroencephalographs (EEG) were recorded. We calculated the coherences of the event-related EEG signals between different functional brain regions and used the repeated measure analysis of variance (ANOVA) to analyze the coherences. The results revealed, (1) The depressed patients had a significantly lower inter-hemisphere coherence than did the normal controls at frontal sites across all EEG basic rhythms; (2) The inter-hemispheric coherence of EEG beta activity was significantly correlated with the emotional processing during 1-200 ms after stimulus onset, and the synchronicity with the negative emotion stimulus was higher than that with neutral and positive stimuli; (3) The main effect of race was found at delta and theta bands at about 401-600 ms after stimulus onset. Moreover, the connectivity of inter-hemisphere for own-race stimulus was stronger than that for other-race stimulus.

Forest regeneration is an important process driven by forest ecological dynamic resources. More and more concern has been given to forest succession issues since the development of forest succession theory during the early twentieth century. Scientific management of forest ecosystem entails the regulations and research models of forest succession. It is of great practical and theoretical significance to restore and reconstruct forest vegetation and to protect natural forest. Disturbances are important factors affecting regeneration structure and ecological processes. They result in temporal and spatial variations of forest ecosystem, and change the efficiencies of resources. In this paper, some concepts about forest succession and disturbances were introduced, and the difficulties of forest succession were proposed. Four classes of models were reviewed: Markov model, GAP model, process-based equilibrium terrestrial biosphere models (BIOME series models), and non-linear model. Subsequently, the effects of climate change on forest succession caused by human activity were discussed. At last, the existing problem and future research directions were proposed.