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Objective To investigate the diversity and composition of gut microbiota in patient with cholestatic liver disease, and explore their correlation with clinical parameters. Methods Fresh stool samples from 16 patients with cholestatic liver disease and 19 healthy controls were collected, and 16S rRNA sequencing was used to analyze the diversity of gut microbiota and composition characteristics. Pearson analysis was employed to analyze the correlation between the different bacteria and clinical parameters. Results There were no statistical differences in the baseline data, such as sex, age and body mass index (BMI) in study subjects (P>0.05), but significant differences were observed in serum indexes among them (P < 0.01). The results of α diversity showed that Chao1 and Shannon indexes were lower in the study group, but there was no statistical difference (P>0.05). β diversity results indicated that the species diversity had significant difference between 2 group (P < 0.01). Further analysis of microbiota composition showed largely relative abundance of Bacteroides, Lachnoclostridium, Veillonella, Roseburia and Escherichia shigella (P < 0.05), while the abundance of Blautia were dramatically decreased (P < 0.05). Pearson analysis displayed that Lachnoclostridium was strongly correlated with serum level of alkaline phosphatase (ALP) (P < 0.01) and gamma-glutamyl transferase (GGT) (P < 0.05), and Veillonella was also strongly correlated with GGT (P < 0.05). Conclusion Compared with healthy controls, the patients with cholestatic liver disease have obvious characteristic changes in the gut microbiota. The relatively high abundance of Veillonella is closely assocatied with cholestatic liver disease.

A novel inorganic anchoring agent can be prepared by using magnesium phosphate cement (MPC) mortar. Through the research on the spread fluidity and the setting time of the magnesium phosphate cement mortar, the compressive strength and the uniaxial anchorage drawing strength of the magnesium phosphate cement mortar are tested. The results show due to the particle filling and the chemically bonding of the fly ash in MPC,the shrinkage strain of the magnesium phosphate cement mortar is obviously reduced; and the SEM, XCT scanning and the 3D reconstruction analysis are utilized, MPC hydration products are uniformly distributed between the standard sand and the unreacted MgO particles,so that the magnesium phosphate cement mortar has higher compressive strength and uniaxial anchorage drawing strength. Moreover, both physical adhere and chemical bonding are in the interface between MPC and bars. [ABSTRACT FROM AUTHOR]

A novel inorganic anchoring agent can be prepared by using magnesium phosphate cement (MPC) mortar. Through the research on the spread fluidity and the setting time of the magnesium phosphate cement mortar, the compressive strength and the uniaxial anchorage drawing strength of the magnesium phosphate cement mortar are tested. The results show due to the particle filling and the chemically bonding of the fly ash in MPC,the shrinkage strain of the magnesium phosphate cement mortar is obviously reduced;and the SEM,XCT scanning and the 3D reconstruction analysis are utilized,MPC hydration products are uniformly distributed between the standard sand and the unreacted MgO particles,so that the magnesium phosphate cement mortar has higher compressive strength and uniaxial anchorage drawing strength. Moreover, both physical adhere and chemical bonding are in the interface between MPC and bars. [ABSTRACT FROM AUTHOR]

The sponge city facilities are optimized and designed in consideration of less permeable underlying surface and more impermeable underlying surface of Changzhen depot of Shenzhen metro. In addition to the traditional sponge city facilities such as raingarden, grass planting ditch and underground water storage modules, innovative sponge city facilities such as ecological roof, bioretention parterre and multifunctional pond are designed. The retention capacity and effect of the sponge city facilities of three design schemes are calculated and simulated by volumetric method and storm water management model ( SWMM). The results show that the sponge city facilities of three design schemes can meet the design requirements of zero runoff under annual runoff control rate of 70%. The results of SWMM simulation show that sponge city facilities can reduce the runoff volume, runoff peak and runoff coefficient of Changzhen depot; however, the reduction effect of sponge city facilities gradually decreases with the increase of rainfall return period, and sponge city facilities almost have no reduction effect when the rainfall return period is more than or equal to 50 years. Considering the technical and economic factors, the second design scheme is selected as the sponge city implementation scheme of Changzhen depot. According to the requirements of the code for construction and acceptance of urban landscaping projects (CTJ/T 82-2012) and the code for green construction of building (GB/T 50905-2014), the sponge city facilities of Changzhen depot as a green construction have finished and have become the first metrosponge city project in the world, which lays a foundation for the promotion and application of sponge city concept in urban rail transit projects. [ABSTRACT FROM AUTHOR]