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Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background Knee osteoarthritis (KOA) is a common clinical condition with a decades-long course. Long-term and personalised health management in community hospitals is the best way to prevent and treat KOA, and non-surgical treatment is an effective way to slow joint degeneration and postpone joint replacement surgery. Objective To understand the population characteristics, clinical staging and treatment modality characteristics of the population attending community hospitals for knee osteoarthritis, in order to provide a basis for optimising the treatment protocol for knee osteoarthritis at the grassroots level. Method All streets in the urban area of Beijing were randomly selected for the study using the whole cluster sampling method, and Hepingli Street in Dongcheng District, Beijing was censored for all patients who attended all community hospitals (7) belonging to the street from January to June 2022, and general information, medical history, personal history, clinical staging, K-L grading and treatment modalities were collected. Results A total of 3 615 KOA patients were included in this study, including 1 327 males (36.71%) and 2 288 females (63.29%), aged (71.8±13.3) years. There were 867 cases (23.98%) in the onset period, 2009 cases (55.57%) in the remission period and 739 cases (20.45%) in the rehabilitation period. Gender and age of patients with different clinical stages were not correlated with clinical stages (P>0.05), while BMI (K=0.235) and KL grading (K=0.406) were correlated with clinical stages (P

OBJECTIVE: To probe into the prescription review method that conforms to the medical activities of traditional Chinese medicine clinicians in the hospital according to the Prescription Review Standard in Medical Institutions jointly issued by the National Health Commission of the People’ s Republic of China and other three departments. METHODS: “Application points” of 31 kinds of Chinese patent medicines were established by referring to the drug instructions and relevant information. The historical prescriptions were reviewed, and the diagnosis was categorized into “ consistent diagnosis” “ irregular diagnosis” “ diagnosis to be discussed” and “ inappropriate diagnosis” by comparing with the “application points”. A multi-disciplinary traditional Chinese medicine expert validation approach was adopted to explore the elements and method of prescription review that were in line with mindset and medical behaviors of traditional Chinese medicine clinicians. RESULTS: A method for reviewing the prescriptions of 31 types of Chinese patent medicines in the hospital had been established, including whether the prescribed medication was consistent with the diagnosis, whether the prescribed dosage and usage were correct, whether the course of treatment was appropriate, whether the drug combination was appropriate, and whether there were any contraindications to the use of medicines. CONCLUSIONS: With the core of “conformity of medicine and evidence”, the establishment of prescription review elements and review methods in line with the clinical diagnosis and therapeutic thinking of traditional Chinese medicine clinicians in the hospital, and the standardization of prescription review are of great significance in ensuring the rational use and reducing the risk of Chinese patent medicine [ABSTRACT FROM AUTHOR]

Objective To evaluate the effectiveness and safety of different Chinese patent medicine in improving blood lipid and microcirculation in coronary heart disease patients with phlegm-blood stasis syndrome based on network meta-analysis. Methods The randomized controlled trials (RCTs) of different Chinese patent medicine in the treatment of blood lipid and microcirculation in coronary heart disease patients with phlegm-blood stasis syndrome were collected by searching CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, and Web of science databases from the establishment of the database to April 3, 2023. Literature quality evaluation and network meta-analysis were conducted using Review Manager 5.4 and Stata15.1 software. Results Thirty-seven RCTs were included, with a total sample size of 4 064 cases, involving 15 different Chinese patent medicines. The network meta-analysis showed that the efficacy of Chinese patent medicine combined with conventional Western medicine is often better than that of conventional Western medicine alone. There are no serious adverse reactions. The top three Chinese patent medicines with cumulative probability of total clinical efficacy were Guanmai Zaitong soft extract, Gualoupi Injection and Quyu Xiaoban Capsule. In terms of improving triglyceride (TG) and low-density lipoprotein (LDL-C), the top three Chinese patent medicines were Gualoupi Injection, Huxinkang Tablet and Guanxin Shutong Capsule. In terms of improving plasma viscosity and fibrinogen, the top three Chinese patent medicines were Ginkgo Damo Injection, Gualoupi Injection and Guanxin Shutong Capsule. In terms of improving endothelial function [nitric oxide (NO) and endothelin-1 (ET-1)], the top three Chinese patent medicines were Ginkgo Damo Injection, Danlou Tablet and Tongmai Yuxin Pill. In terms of reducing inflammation hypersensitivity C-reactive protein (hs-CRP), the top three Chinese patent medicines were Ginkgo Damo Injection, Huxinkang Tablet and Guanxin Shutong Capsule. Conclusion The current evidence shows that the combination of TCM, which is used for the treatment of phlegm-blood stasis syndrome, with conventional Western medicine in the treatment of coronary heart disease has advantages in improving clinical efficacy, blood lipids and microcirculation. TCM especially for the treatment of phlegm-blood stasis syndrome shows more obvious advantage, such as Guanmai Zaitong soft extract and Gualoupi injection, which can be taken into consideration as part of the clinical guidelines. However, due to the limited number and quality of the included literatures, the research results still need to be verified by more high-quality, multi-center, double-blind randomized trials. The purpose is to provide more reliable evidence-based medical reference. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the clinical application rationality of Chinese patent medicines based on the application of Chinese patent medicine and the review of special medical orders in a grade Ⅲ, level A integrated traditional Chinese and Western Medicine hospital ( hereinafter referred to as “ the hospital ”). METHODS: Retrospective study was conducted to analyze the categories, consumption sum, use intensity, defined daily dose system (DDDs), drug consumption sum ranking (B) / DDDs ranking (A) and adverse drug reactions (ADR) related to Chinese patent medicines in the ward of the hospital from 2021 to 2022. Totally 4 800 inpatient medical orders with Chinese patent medicines from 2021 to 2022 were selected for special medical order review, and irrational drug use problems existing in clinical application of Chinese patent medicines were summarized and analyzed. RESULTS: Traditional Chinese medicine injections were widely used in the inpatient department of this hospital. The top 5 drugs ranked by consumption sum in 2 consecutive years included Shenkang injection, brucea jananica oil injection, and Xingnaojing injection. Shenkang injection and brucea jananica oil injection ranked the top 3 in terms of use intensity. The drugs with B / A > 1. 5 were Ningmitai capsules, Kuanxiong aerosol inhalation and Peiyuan Tongnao capsules, Shenkang injection with B / A <0. 5 for 2 consecutive years, while the B / A of most Chinese patent medicines was from 0. 5 to 1. 5. Among the 4 800 inpatient medical orders with Chinese patent medicines, there were 465 cases (9. 69%) with irrational drug use. The irrational drug use problems were mainly related to drugs of dampness removing, drugs of blood stasis removing and resuscitation, which were mainly manifested as inappropriate indications, repeated drug use, improper drug combination, and inappropriate usage, dosage and course of treatment. In the ADR reports related to Chinese patent medicines, oral dosage forms accounted for the highest proportion, followed by injections CONCLUSIONS: The clinical application of Chinese patent medicine in the hospital is basically reasonable, and it is necessary to focus on the use of traditional Chinese medicine injections and ADR, and further promote clinical rational drug use and reduce adverse drug reactions by carrying out the relevant work of medical order review and strengthening medication supervision. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To investigate the current status of clinical use of Chinese patent medicines in pediatrics through the indication review of Chinese patent medicines in pediatric outpatient and emergency departments in 13 medical institutions, and to put forward relevant countermeasures and suggestions for the existing problems. METHODS: Retrospective analysis method was used to collect the prescriptions of Chinese patent medicines in pediatric outpatient and emergency departments of 13 medical institutions from Oct. to Dec. 2019. The rational prescription, controversial prescription and irrational prescription were judged in terms of indications, and the results of each judgment and the priority of the specific varieties in the use problem were statistically analyzed. RESULTS: Among the 434 221 Chinese patent medicine prescriptions, 284 257 (65. 46%) were rational prescriptions in terms of indications, 130 238 (29. 99%) were controversial prescriptions, and 19 726 (4. 54%) were irrational prescriptions. Among them, the most controversial prescription was the antipyretic agent, and the most controversial prescription was the use of Xiao’ er Chiqiao Qingre granules. Most of the irrational prescriptions were supplement and supporting agents, yet Lingyangjiao capsule was the most irrational. CONCLUSIONS: According to the investigation, there are some controversial problems in the clinical use of commonly used Chinese patent medicines in pediatrics, which can be further studied by Delphi method by making expert questionnaire, so as to establish the corresponding prescription review rules. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Fuzhou University is the property of Journal of Fuzhou University, Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Food Safety & Quality is the property of Journal of Food Safety & Quality Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With scarce resources, natural Bovis Calculus is expensive and hard to meet clinical demand. At the moment, four kinds of Bovis Calculus are available on the market: the natural product, in vitro cultured product, synthesized product, and the product formed in cow after manual intervention. In this study, papers on the four kinds of Bovis Calculus products and relevant Chinese patent medicines were searched from Web of Science, PubMed, and China National Knowledge Infrastructure(CNKI). CiteSpace, citexs AI, and CNKI were employed for bibliometric analysis and knowledge map analysis. On this basis, the status, trend, and focuses of research on Bovis Calculus and relevant Chinese patent medicines were summarized. The results suggested overall slow development in the research on Bovis Calculus and relevant Chinese patent medicines with three typical growth stages. It is consistent with the development of Bovis Calculus substitutes and the national policy for the development of traditional Chinese medicine. At the moment, the research on Bovis Calculus and relevant Chinese patent medicines has been on the rise. In recent years, there has been an explosion of research on them, particularly the quality control of Bovis Calculus and the Chinese patent medicines, the pharmacological efficacy of Chinese patent medicines, such as Angong Niuhuang Pills, and the comparison of the quality of various Bovis Calculus products. However, there is a paucity of research on the pharmacological efficacy and the mechanism of Bovis Calculus. This medicinal and the relevant Chinese patent medicines have been studied from diverse perspectives and China becomes outstanding in this research field. However, it is still necessary to reveal the chemical composition, pharmacological efficacy, and mechanism through multi-dimensional deep research.

This study summarized and analyzed the current acne-relieving Chinese medicinal health products and Chinese patent medicines,aiming at providing references for the formulation and development of acne-relieving health products. The information on acne-relieving health products published by the Department of Special Food Safety Supervision and Management,the State Administration for Market Regulation( SAMR) was retrieved,and the Chinese patent medicines on DRUGDATAEXPY were searched. Microsoft Excel and the Traditional Chinese Medicine Inheritance Support System V2. 5( TCMISS) were employed to statistically analyze the characteristics of formulations. Forty-three acne-relieving health products were obtained,including 40 ones containing Chinese herbal medicines. Six Chinese herbal medicines showed a usage frequency ≥8,with 61 times in use totally,including Salviae Miltiorrhizae Radix et Rhizoma( 13),Lonicerae Japonicae Flos( 12),Taraxaci Herba( 11),ALOE( 9),Carthami Flos( 8),and Rhei Radix et Rhizoma( 8). A total of 29 Chinese patent medicines with similar efficacy were collected in DRUGDATAEXPY. Nine Chinese herbal medicines showed a usage frequency ≥6,with 63 times in use,including Rhei Radix et Rhizoma( 10),Glycyrrhizae Radix et Rhizoma( 8),Scutellariae Radix( 8),Lonicerae Japonicae Flos( 7),Angelicae Sinensis Radix( 6),Paeoniae Radix Rubra( 6),Astragali Radix( 6),Paeoniae Radix Alba( 6),and Gardeniae Fructus( 6). Through unsupervised hierarchical entropy-based clustering of the above-mentioned Chinese medicinal health products and Chinese patent medicines,five and three new formulas were obtained,respectively. The selection of Chinese herbal medicines was consistent with the principles of traditional Chinese medicine( TCM) theories in relieving acne,i. e.,dispelling exterior wind,ventilating lungs,clearing heat,dissipating mass,promoting diuresis,relaxing bowels,removing toxin,activating blood,resolving stasis,eliminating phlegm,and regulating Qi. According to the &quot; lung governing skin and body hair&quot; and &quot; interior-exterior relationship between lung and large intestine&quot; in TCM theories,the idea that acne could be treated by relieving constipation was proposed,which provided new methods and references for the research and development of Chinese medicinal health products.

In 2018,Standardization Department of China Association of Chinese Medicine invited methodologists with the background of evidence-based medicine to discuss and draft a series of standards for expert consensus on clinical practice of Chinese patent medicines. These standards have been made by reference to the published standards for developing expert consensus and clinical practice guidelines. These standards were made based on full consideration of the current evidence status and the history of clinical practice of Chinese patent medicines. These standards were composed of four parts,namely information summary items,normative general items,normative technical items and information supplementary items,including cover,content,preface,introduction,title,scope,basic Information of Chinese patent medicine,suggestions for clinical application,safety,conflict of interest,appendix,and references,so as to provides reference for improving the quality of expert consensus-based compilation and enhancing the applicability of expert consensus.

The expert consensus on clinical practice of Chinese patent medicines shall be regarded as the same with clinical practice guidelines,which shall be concise,readable and applicable. Therefore,a formal expert consensus is unable to contain the whole compilation process and the content of its important process documents. It is necessary to write instructions for continuation,expansion and publicity. In 2018 Standardization Department of China Association of Chinese Medicine invited methodologists with the background of evidence-based medicine drafted a series of standards for expert consensus on clinical practice of Chinese patent medicines,including the guidance for compilation the instructions. It will be useful for readers of expert consensus to understand the work behind the compilation,so as to make the compilation process more transparent and standardized. We proposed nine requirements for compilation the instructions,namely content and requirements,work overview,main technical content,compilation process,process and basis for handling major disagreements,expert consensus implementation requirements and measure suggestions,other issues need to be explained,appendix and format for instructions.

Objective: To study the antimicrobial effect of 5kinds of Chinese patent medicines and to establish microbial limit test method for them. Methods: Common method and culture medium dilution method were used to do the recovery test in order to establish and validate the method. Result: Yinhuang oral liquid showed an antimicrobial effect on Staphylococcus aureus to some extent but the effect can be eliminated by culture medium dilution method.Other 4kinds did not show an antimicrobial effect. Conclusion: The common method can be used for the microbial limit test of Taian oral liquid, sodium bicarbonate solution,chloral hydrate clyster and tannin ointment.Dilution method can be used for the microbial limit test of Yinhuang oral liquid. [ABSTRACT FROM AUTHOR]