24 results on '"Jiao, Yao"'
Search Results
2. Stevioside reduces inflammation in periodontitis by changing the oral bacterial composition and inhibiting P. gingivalis in mice
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Han, Wenrui, Jiao, Yao, Mi, Sicong, Han, Shu, Xu, Junji, Li, Song, Liu, Yi, and Guo, Lijia
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- 2023
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3. The safety of digestive tract cancer surgery during COVID-19: A living systematic review and meta-analysis
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Qiu-xiang Wang, Juan Wang, Rui-ke Wu, Yi-lin Li, Cheng-jiao Yao, Feng-jiao Xie, Qin Xiong, and Pei-min Feng
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COVID-19 pandemic ,digestive tract cancer ,meta-Analysis ,Surgery ,RD1-811 - Abstract
Surgery is the primary curative treatment of solid cancers. However, its safety has been compromised by the outbreak of COVID-19. Therefore, it is necessary to evaluate the safety of digestive tract cancer surgery in the context of COVID-19. We used the Review Manager software (v.5.4) and Stata software (version 16.0) for meta-analysis and statistical analysis. Sixteen retrospective studies involving 17,077 patients met the inclusion criteria. The data indicates that performing digestive tract cancer surgery during the COVID-19 pandemic led to increased blood loss(MD = -11.31, 95%CI:-21.43 to −1.20, P = 0.03), but did not increase postoperative complications(OR = 1.03, 95%CI:0.78 to1.35, P = 0 0.86), anastomotic leakage (OR = 0.96, 95%CI:0.52 to1.77, P = 0 0.89), postoperative mortality (OR = 0.65, 95%CI:0.40 to1.07, P = 0 0.09), number of transfusions (OR = 0.74, 95%CI:0.30 to 1.80, P = 0.51), number of patients requiring ICU care(OR = 1.37, 95%CI:0.90 to 2.07, P = 0.14), postoperative 30-d readmission (OR = 0.94, 95%CI:0.82 to 1.07, P = 0 0.33), total hospital stay (MD = 0.11, 95%CI:-2.37 to 2.59, P = 0.93), preoperative waiting time(MD = − 0.78, 95%CI:-2.34 to 0.79, P = 0.33), postoperative hospital stay(MD = − 0.44, 95%CI:-1.61 to 0.74, P = 0.47), total operation time(MD = -12.99, 95%CI:-28.00 to 2.02, P = 0.09) and postoperative ICU stay (MD = − 0.02, 95%CI:-0.62 to 0.57, P = 0.94). Digestive tract cancer surgery can be safely performed during the COVID-19.
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- 2023
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4. Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease
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Qian Yan, Shasha Liu, Yang Sun, Chen Chen, Songwei Yang, Meiyu Lin, Junpeng Long, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, Naihong Chen, and Yantao Yang
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Cardiovascular disease ,Oxidative stress ,Herb monomer ,Antioxidative ,Medicine - Abstract
Abstract Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis (AS), and myocardial infarction (MI). Oxidative stress (OS) plays a crucial role in the pathogenesis and advancement of CVDs, highlighting its significance as a contributing factor. Maintaining an equilibrium between reactive oxygen species (ROS) and antioxidant systems not only aids in mitigating oxidative stress but also confers protective benefits on cardiac health. Herbal monomers can inhibit OS in CVDs by activating multiple signaling pathways, such as increasing the activity of endogenous antioxidant systems and decreasing the level of ROS expression. Given the actions of herbal monomers to significantly protect the normal function of the heart and reduce the damage caused by OS to the organism. Hence, it is imperative to recognize the significance of herbal monomers as prospective therapeutic interventions for mitigating oxidative damage in CVDs. This paper aims to comprehensively review the origins and mechanisms underlying OS, elucidate the intricate association between CVDs and OS, and explore the therapeutic potential of antioxidant treatment utilizing herbal monomers. Furthermore, particular emphasis will be placed on examining the cardioprotective effects of herbal monomers by evaluating their impact on cardiac signaling pathways subsequent to treatment. Graphical Abstract
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- 2023
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5. Novel insights into macrophage immunometabolism in nonalcoholic steatohepatitis
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Yuan, Yali, Zhang, Ye, Lu, Xinyu, Li, Junxiang, Wang, Muyuan, Zhang, Wenji, Zheng, Mengyu, Sun, Zhongmei, Xing, Yunqi, Li, Yitong, Qu, Yingdi, Jiao, Yao, Han, Haixiao, Xie, Chune, and Mao, Tangyou
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- 2024
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6. Targeting pyroptosis as a preventive and therapeutic approach for stroke
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Junpeng Long, Yang Sun, Shasha Liu, Songwei Yang, Chen Chen, Zhao Zhang, Shifeng Chu, Yantao Yang, Gang Pei, Meiyu Lin, Qian Yan, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, and Naihong Chen
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Stroke has caused tremendous social stress worldwide, yet despite decades of research and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue plasminogen activator) is still the accepted treatment for ischemic stroke. the complexity of the stroke mechanism has led to unsatisfactory efficacy of most drugs in clinical trials, indicating that there are still many gaps in our understanding of stroke. Pyroptosis is a programmed cell death (PCD) with inflammatory properties and are thought to be closely associated with stroke. Pyroptosis is regulated by the GSDMD of the gasdermin family, which when cleaved by Caspase-1/Caspase-11 into N-GSDMD with pore-forming activity can bind to the plasma membrane to form small 10–20 nm pores, which would allow the release of inflammatory factors IL-18 and IL-1β before cell rupture, greatly exacerbating the inflammatory response. The pyroptosis occurs mainly in the border zone of cerebral infarction, and glial cells, neuronal cells and brain microvascular endothelial cells (BMECs) all undergo pyroptosis after stroke, which largely exacerbates the breakdown of the blood-brain barrier (BBB) and thus aggravates brain injury. Therefore, pyroptosis may be a good direction for the treatment of stroke. In this review, we focus on the latest mechanisms of action of pyroptosis and the process by which pyroptosis regulates stroke development. We also suggest potential therapeutic stroke drugs that target the pyroptosis pathway, providing additional therapeutic strategies for the clinical management of stroke. The role of pyroptosis after stroke. After stroke, microglia first rush to the damaged area and polarize into M1 and M2 types. Under the influence of various stimuli, microglia undergo pyroptosis, release pro-inflammatory factors, and are converted to the M1 type; astrocytes and neuronal cells also undergo pyroptosis under the stimulation of various pro-inflammatory factors, leading to astrocyte death due to increased osmotic pressure in the membrane, resulting in water absorption and swelling until rupture. BMECs, the main structural component of the BBB, also undergo pyroptosis when stimulated by pro-inflammatory factors released from microglia and astrocytes, leading to the destruction of the structural integrity of the BBB, ultimately causing more severe brain damage. In addition, GSDMD in neutrophils mainly mediate the release of NETs rather than pyroptosis, which also aggravates brain injury. IL-10=interleukin-10; TGF-β = transforming growth factor-β; IL-18=interleukin-18; IL-1β = interleukin-1β; TNF-α = tumor necrosis factor-α; iNOS=induced nitrogen monoxide synthase; MMPs=Matrix metalloproteinases; GSDMD = gasdermin D; BMECs=brain microvascular endothelial cells; BBB = blood-brain barrier.
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- 2023
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7. The mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertension
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Yang Sun, Shasha Liu, Chen Chen, Songwei Yang, Gang Pei, Meiyu Lin, Ting Wang, Junpeng Long, Qian Yan, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, Naihong Chen, and Yantao Yang
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Pulmonary hypertension (PH) was a cardiovascular disease with high morbidity and mortality. PH was a chronic disease with complicated pathogenesis and uncontrollable factors. PH was divided into five groups according to its pathogenesis and clinical manifestations. Although the treatment and diagnosis of PH has made great progress in the past ten years. However, the diagnosis and prognosis of the PAH had a great contrast, which was not conducive to the diagnosis and treatment of PH. If not treated properly, it will lead to right ventricular failure or even death. Therefore, it was necessary to explore the pathogenesis of PH. The problem we urgently need to solve was to find and develop drugs for the treatment of PH. We reviewed the PH articles in the past 10 years or so as well as systematically summarized the recent advance. We summarized the latest research on the key regulatory factors (pyroptosis, apoptosis, necroptosis, ferroptosis, and endoplasmic reticulum stress) involved in PH. To provide theoretical basis and basis for finding new therapeutic targets and research directions of PH.
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- 2023
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8. Gut dysbacteriosis attenuates resistance to Mycobacterium bovis infection by decreasing cyclooxygenase 2 to inhibit endoplasmic reticulum stress
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Haoran Wang, Jiao Yao, Yulan Chen, Yuanzhi Wang, Yiduo Liu, Yi Liao, Zhengmin Liang, Yu hui Dong, Mengjin Qu, Xin Ge, and Xiangmei Zhou
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Gut dysbacteriosis ,cyclooxygenase 2 ,Mycobacterium bovis ,endoplasmic reticulum stress ,apoptosis ,faecal transplant ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
The role of gut microbiota has been described as an important influencer of the immune system. Gut-lung axis is critical in the prevention of mycobacterium infection, but the specific mechanism, by which dysbiosis affects tuberculosis, has not been reported. In this study, we attempted to provide more information on how the gut-lung axis contributes to Mycobacterium bovis (M. bovis) infection. Mice are pre-treated with broad-spectrum antibiotics cocktail (Abx) to induce gut dysbiosis. Interestingly, dysbiosis of microbes showed a significant increase in the bacterial burden in the lungs and inhibited the level of COX-2. After faecal transplantation, cyclooxygenase 2 (COX-2) expression was restored and the inflammatory lesion in the lungs was reduced. Further research found that the deficiency of COX-2 inhibited endoplasmic reticulum stress (ER stress). This mechanism was completed by COX-2 interaction with BIP. Moreover, we found a positive feedback mechanism by which blocking ER stress could reduce COX-2 levels by the NF-κB pathway. Taken together, we reveal for the first time gut dysbacteriosis exacerbates M. bovis disease by limiting the COX-2/ER stress pathway. The finding strengthens the foundation of gut microbiota-targeted therapy for tuberculosis treatment.
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- 2022
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9. Fundamentals and advances of ligand field theory in understanding structure-electrochemical property relationship of intercalation-type electrode materials for rechargeable batteries
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Wang, Da, Jiao, Yao, Shi, Wei, Pu, Bowei, Ning, Fanghua, Yi, Jin, Ren, Yuan, Yu, Jia, Li, Yajie, Wang, Hongxia, Li, Biao, Li, Yutao, Nan, Cewen, Chen, Liquan, and Shi, Siqi
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- 2023
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10. CFP10–loaded PLGA nanoparticles as a booster vaccine confer protective immunity against Mycobacterium bovis
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Zhengmin Liang, Miaoxuan Li, Jiamin Ni, Tariq Hussain, Jiao Yao, Yinjuan Song, Yiduo Liu, Haoran Wang, and Xiangmei Zhou
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plga ,nanoparticles ,cfp10 ,mycobacterium bovis ,mucosal immunization ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Introduction: The limited efficacy of BCG (bacillus Calmette–Guérin) urgently requires new effective vaccination approaches for the control of tuberculosis. Poly lactic-co-glycolic acid (PLGA) is a prevalent drug delivery system. However, the effect of PLGA-based nanoparticles (NPs) against tuberculosis for the induction of mucosal immune response is no fully elucidated. In this study, we hypothesized that intranasal immunization with culture filtrate protein-10 (CFP10)-loaded PLGA NPs (CFP10-NPs) could boost the protective immunity of BCG against Mycobacterium bovis in mice. Methods: The recombinant protein CFP10 was encapsulated with PLGA NPs to prepare CFP10-NPs by the classical water–oil-water solvent-evaporation method. Then, the immunoregulatory effects of CFP10-NPs on macrophages in vitro and on BCG-immunized mice in vivo were investigated. Results: We used spherical CFP10-NPs with a negatively charged surface (zeta-potential −28.5 ± 1.7 mV) having a particle size of 281.7 ± 28.5 nm in diameter. Notably, CFP10-NPs significantly enhanced the secretion of tumor necrosis factor α (TNF-α) and interleukin (IL)-1β in J774A.1 macrophages. Moreover, mucosal immunization with CFP10-NPs significantly increased TNF-α and IL-1β production in serum, and immunoglobulin A (IgA) secretion in bronchoalveolar lavage fluid (BALF), and promoted the secretion of CFP10-specific interferon-γ (IFN-γ) in splenocytes of mice. Furthermore, CFP10-NPs immunization significantly reduced the inflammatory area and bacterial load in lung tissues at 3-week post-M. bovis challenge. Conclusion: CFP10-NPs markedly improve the immunogenicity and protective efficacy of BCG. Our findings explore the potential of the airway mucosal vaccine based on PLGA NPs as a vehicle for targeted lung delivery.
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- 2022
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11. Sodium butyrate inhibits osteogenesis in human periodontal ligament stem cells by suppressing smad1 expression
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Hou, Jingyi, Xu, Junji, Liu, Yi, Zhang, Haiping, Wang, Sihan, Jiao, Yao, Guo, Lijia, and Li, Song
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- 2022
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12. FABP5 Deficiency Impairs Mitochondrial Function and Aggravates Pathological Cardiac Remodeling and Dysfunction
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Gao, Shanquan, Li, Guoqi, Shao, Yihui, Wei, Zhipeng, Huang, Shan, Qi, Feiran, Jiao, Yao, Li, Yulin, Zhang, Congcong, and Du, Jie
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- 2021
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13. Coordination of EZH2 and SOX2 specifies human neural fate decision
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Yuan Zhao, Tianyu Wang, Yanqi Zhang, Liang Shi, Cong Zhang, Jingyuan Zhang, Jiao Yao, Qianyu Chen, Xiaofen Zhong, Yanxing Wei, Yongli Shan, and Guangjin Pan
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Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Polycomb repressive complexes (PRCs) are essential in mouse gastrulation and specify neural ectoderm in human embryonic stem cells (hESCs), but the underlying molecular basis remains unclear. Here in this study, by employing an array of different approaches, such as gene knock-out, RNA-seq, ChIP-seq, et al., we uncover that EZH2, an important PRC factor, specifies the normal neural fate decision through repressing the competing meso/endoderm program. EZH2−/− hESCs show an aberrant re-activation of meso/endoderm genes during neural induction. At the molecular level, EZH2 represses meso/endoderm genes while SOX2 activates the neural genes to coordinately specify the normal neural fate. Moreover, EZH2 also supports the proliferation of human neural progenitor cells (NPCs) through repressing the aberrant expression of meso/endoderm program during culture. Together, our findings uncover the coordination of epigenetic regulators such as EZH2 and lineage factors like SOX2 in normal neural fate decision.
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- 2021
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14. The charge localization deteriorating the thermoelectric properties: The case of kiddcreekite-type Cu6WSnSe8
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Jiang, Yumei, Weng, Tianyao, Lin, Chen, Jiao, Yao, Guo, Kai, Wang, Da, Dong, Cheng, Zhang, Jiye, and Luo, Jun
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- 2021
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15. A Review of Research on the Association between Neuron–Astrocyte Signaling Processes and Depressive Symptoms
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Jiao Yao, Cong Chen, Yi Guo, Yantao Yang, Xinya Liu, Shifeng Chu, Qidi Ai, Zhao Zhang, Meiyu Lin, Songwei Yang, and Naihong Chen
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depression ,neurons ,astrocytes ,astrocyte–neuron interactions ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Depression is a mental illness that has a serious negative impact on physical and mental health. The pathophysiology of depression is still unknown, and therapeutic medications have drawbacks, such as poor effectiveness, strong dependence, adverse drug withdrawal symptoms, and harmful side effects. Therefore, the primary purpose of contemporary research is to understand the exact pathophysiology of depression. The connection between astrocytes, neurons, and their interactions with depression has recently become the focus of great research interest. This review summarizes the pathological changes of neurons and astrocytes, and their interactions in depression, including the alterations of mid-spiny neurons and pyramidal neurons, the alterations of astrocyte-related biomarkers, and the alterations of gliotransmitters between astrocytes and neurons. In addition to providing the subjects of this research and suggestions for the pathogenesis and treatment techniques of depression, the intention of this article is to more clearly identify links between neuronal–astrocyte signaling processes and depressive symptoms.
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- 2023
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16. Advances in the Study of Extracellular Vesicles for Bone Regeneration.
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Jiao, Yao, Liu, Yitong, Du, Juan, Xu, Junji, Luo, Zhenhua, Liu, Yi, and Guo, Lijia
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BONE regeneration , *EXTRACELLULAR vesicles , *BONE diseases , *CELLULAR therapy , *IMMUNE response , *REGENERATION (Biology) - Abstract
Promoting the efficiency of bone regeneration in bone loss diseases is a significant clinical challenge. Traditional therapies often fail to achieve better therapeutic outcomes and shorter treatment times. However, in recent years, extracellular vesicles (EVs) have gained significant attention due to their exceptional osteogenic function in bone regeneration and superior therapeutic effects compared to traditional cell therapy. EVs have emerged as a promising therapy for tissue defect regeneration due to their various physiological functions, such as regulating the immune response and promoting tissue repair and regeneration. Moreover, EVs have good biocompatibility, low immunogenicity, and long-term stability, and can be improved through pretreatment and other methods. Studies investigating the mechanisms by which extracellular vesicles promote bone regeneration and applying EVs from different sources using various methods to animal models of bone defects have increased. Therefore, this paper reviews the types of EVs used for bone regeneration, their sources, roles, delivery pathways, scaffold biomaterials, and applications. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Comprehensive Evaluation of Operational Efficiency of Intersections in Arterial Considering Pedestrians Yield Rule
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Lei Chen, Junjie Li, Yuhang Li, and Jiao Yao
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Transportation engineering ,TA1001-1280 ,Transportation and communications ,HE1-9990 - Abstract
Yield to pedestrians has become a new trend of civilized transportation in the metropolis. In order to evaluate the influence of yield behavior on the comprehensive operation efficiency of signalized intersections in arterial, the efficiency of the subject who gives way and the subject who is given up in the process of yielding to pedestrians was considered in this study, and the comprehensive operation evaluation of intersection in arterial was given. First, based on the rule of pedestrians yield, the concept of a safe headway gap of pedestrians was introduced in the process of conflict analysis of traffic flows at the intersection, and 3 situations were discussed, which are no yield, yield to 1 flow and 2 flows, to calculate the departure rate of traffic flow at the intersection. Furthermore, models of 3 evaluation indices were established, which are number of people passing per unit time, average delay per people, and average yield number per people at intersection. Moreover, the entropy weight method was taken to decide the weight of these 3 indices, and to calculate the comprehensive efficiency evaluation of intersection operation, with the standardized matrix. Finally, case study work was carried out to evaluate the comprehensive efficiency of 4 types of intersections in arterial considering pedestrians yield rule, which is the intersection between arterial and arterial (IAA), intersection between arterial and subarterial (IAS), intersection with one-time (IAA-1, IAS-1), and two-time (IAA-2, IAS-2) crossing of pedestrians. The relevant results show that the impact of an increase in the number of pedestrians on the combined efficiency of arterial intersections can vary dramatically in different scenarios. Therefore, in the implementation process of “yielding to pedestrians,” the flow fluctuation characteristics and channelization of each intersection should be taken into account, and the corresponding phase changes should be based on pedestrian and vehicle volumes to improve the efficiency of all parts, such as pedestrians and drivers.
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- 2022
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18. New Therapeutic Approaches to and Mechanisms of Ginsenoside Rg1 against Neurological Diseases
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Yang Sun, Yantao Yang, Shasha Liu, Songwei Yang, Chen Chen, Meiyu Lin, Qi Zeng, Junpeng Long, Jiao Yao, Fan Yi, Lei Meng, Qidi Ai, and Naihong Chen
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ginsenoside ,Rg1 ,inflammation ,oxidative stress ,Cytology ,QH573-671 - Abstract
Neurological diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury, depression and, stress, have high incidence and morbidity and often lead to disability. However, there is no particularly effective medication against them. Therefore, finding drugs with a suitable efficacy, low toxicity and manageable effects to improve the quality of life of patients is an urgent problem. Ginsenoside Rg1 (Rg1) is the main active component of ginseng and has a variety of pharmacological effects. In this review, we focused on the therapeutic potential of Rg1 for improving neurological diseases. We introduce the mechanisms of Ginsenoside Rg1 in neurological diseases, including apoptosis, neuroinflammation, the microRNA (miRNA) family, the mitogen-activated protein kinase (MAPK) family, oxidative stress, nuclear factor-κB (NF-κB), and learning and memory of Rg1 in neurological diseases. In addition, Rg1 can also improve neurological diseases through the interaction of different signal pathways. The purpose of this review is to explore more in-depth ideas for the clinical treatment of neurological diseases (including PD, AD, HD, stroke, cerebral infarction, ischemia–reperfusion injury, depression, and stress). Therefore, Rg1 is expected to become a new therapeutic method for the clinical treatment of neurological diseases.
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- 2022
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19. Two-Level Programming Model Based on Cooperative Operation Study of Stakeholders in Hazardous Chemical Storage
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Jiao Yao, Beibei Xie, Xiurong Wu, and Cong Zhang
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Renewable Energy, Sustainability and the Environment ,hazardous chemical warehousing ,two-level programming model ,stakeholder ,cooperative operation ,penalty coefficient ,improved adaptive particle algorithm ,Geography, Planning and Development ,Building and Construction ,Management, Monitoring, Policy and Law - Abstract
Due to the uncertainty of risk occurrence and the severity of accident consequences in the process of hazardous chemical storage, there are many stakeholders involved in the management and supervision of hazardous chemical storage, and their interest appeals are different. On the basis of ensuring storage safety, in order to balance the interests of stakeholders and achieve cooperative operation, a two-level programming model considering the maximization of social welfare and the interests of warehousing enterprises was proposed. First, the upper model mainly refers to the regulatory department represented by the government, including the daily supervision cost, risk loss cost, risk compensation cost, and penalty coefficient formulated by combining various indicators. In the lower model, the comprehensive risk level of the warehouse is determined by the warehouse enterprise. Based on this, the supervision coefficient is determined. Combined with the punishment coefficient, the warehousing operation cost, warehousing supervision cost, and the punishment cost when the accident occurs under different risk levels are determined. The relevant case analysis shows that, compared with the evolutionary game model, the social supervision cost of the upper level and the enterprise cost of the lower level can be reduced by 0.49% and 30.43% respectively. Compared with the traditional improved particle swarm optimization algorithm, the proposed algorithm can reduce the supervision cost of the upper society and the lower enterprise by 0.11% and 7.05%, respectively, thus achieving a better supervision effect at a relatively low cost.
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- 2023
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20. Restoration of Folk Document Covers from the Qing Dynasty to the Republic of China.
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Jiao Yao, Fujiang Geng, Huanhuan Wang, and Yunpei Lu
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- 2023
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21. Coordination of EZH2 and SOX2 specifies human neural fate decision
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Yanqi Zhang, Qianyu Chen, Jiao Yao, Yongli Shan, Guangjin Pan, Liang Shi, Tianyu Wang, Jingyuan Zhang, Yanxing Wei, Yuan Zhao, Xiaofen Zhong, and Cong Zhang
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Medicine (General) ,Neuroectoderm ,QH301-705.5 ,fungi ,Cell Biology ,macromolecular substances ,Biology ,Embryonic stem cell ,Neural stem cell ,Cell biology ,Gastrulation ,R5-920 ,medicine.anatomical_structure ,SOX2 ,embryonic structures ,medicine ,Biology (General) ,Stem cell ,Endoderm ,Neural development ,Developmental Biology ,Research Article - Abstract
Polycomb repressive complexes (PRCs) are essential in mouse gastrulation and specify neural ectoderm in human embryonic stem cells (hESCs), but the underlying molecular basis remains unclear. Here in this study, by employing an array of different approaches, such as gene knock-out, RNA-seq, ChIP-seq, et al., we uncover that EZH2, an important PRC factor, specifies the normal neural fate decision through repressing the competing meso/endoderm program. EZH2−/− hESCs show an aberrant re-activation of meso/endoderm genes during neural induction. At the molecular level, EZH2 represses meso/endoderm genes while SOX2 activates the neural genes to coordinately specify the normal neural fate. Moreover, EZH2 also supports the proliferation of human neural progenitor cells (NPCs) through repressing the aberrant expression of meso/endoderm program during culture. Together, our findings uncover the coordination of epigenetic regulators such as EZH2 and lineage factors like SOX2 in normal neural fate decision. Supplementary Information The online version contains supplementary material available at 10.1186/s13619-021-00092-6.
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- 2021
22. Herbal Medicine Hewei Jiangni Decoction Is Noninferior to Oral Omeprazole for the Treatment of Nonerosive Gastroesophageal Reflux Disease: A Randomized, Double-Blind, and Double-Dummy Controlled Trail.
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Li, Feng, Yuan, Yali, Wu, Di, Li, Junxiang, Han, Haixiao, Li, Xiaohong, Hu, Liming, Chen, Runhua, Yao, Yupu, Jiao, Yao, Chen, Huihui, Mao, Tangyou, and Xie, Chune
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DRUG efficacy ,HERBAL medicine ,NAUSEA ,ORAL drug administration ,HEALTH surveys ,MENTAL health ,NON-erosive reflux disease ,TREATMENT effectiveness ,RANDOMIZED controlled trials ,SLEEP disorders ,OMEPRAZOLE ,BLIND experiment ,QUESTIONNAIRES ,STATISTICAL sampling ,PHARMACEUTICAL chemistry ,COMPUTER-assisted molecular modeling ,HEARTBURN ,CHINESE medicine ,EVALUATION - Abstract
Objectives. Conventional approaches for patients with nonerosive gastroesophageal reflux disease (NERD) were not satisfactory. This study aimed to evaluate the effectiveness and mechanisms of Chinese herbal medicine Hewei Jiangni Decoction (HWJND) as a novel and promising regimen for NERD. Methods. A total of 128 patients with NERD were randomly assigned to the Treatment group and Control group. The patients from the Treatment group were administered HWJND (81 g) plus dummy omeprazole (20 mg) daily for 8 weeks, and the others were given dummy HWJND granules (81 g) plus omeprazole (20 mg). The clinical efficacy was assessed using the gastroesophageal reflux disease questionnaire (GERD-Q) scale, patient reported outcomes (PRO) scale, and short form health survey 36 (SF-36) scale at week 4. Moreover, its pharmacological and molecular mechanisms were elucidated based on network pharmacology and molecular docking. Results. Due to case shedding and other reasons, 109 patients, including 56 in the Treatment group and 53 in the Control group completed this study. Our results showed that HWJND significantly improved heartburn, regurgitation, epigastric pain, nausea, and sleep disturbance, which led to a significant reduction of GERD-Q scores in NERD patients. In addition, PRO scores of NERD patients with HWJND administration were improved, and sufficient relief of physical role, body pain, general health, social function, and mental health on the SF-36 scale was also observed in patients after HWJND treatment. We further showed that the curative effect of HWJND was close to that of omeprazole, except for the better improvement of general health and social function. What's more, the main active ingredients of HWJND included quercetin, beta-sitosterol, naringenin, baicalein, and kaempferol were retrieved, and the protective effects of HWJND against NERD may be closely related to targets such as TNF, IL6, IL1B, MMP9, CXCL8, and EGFR, which were mainly enriched in IL-17 signaling pathway and TNF signaling pathway. Conclusion. Our findings demonstrate that HWJND is noninferior to oral omeprazole for the treatment of patients with NERD, plays a therapeutic role through multiple targets and diverse pathways, and holds promise for complementary and alternative therapy for the treatment of NERD. This trial is registered with http://www.chictr.org.cn, Chinese Clinical Trials Registry [ChiCTR2200055960]. [ABSTRACT FROM AUTHOR]
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- 2022
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23. Identifying Migration Channels and Bottlenecks in Monoclinic NASICON‐Type Solid Electrolytes with Hierarchical Ion‐Transport Algorithms.
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Zou, Zheyi, Ma, Nan, Wang, Aiping, Ran, Yunbing, Song, Tao, He, Bing, Ye, Anjiang, Mi, Penghui, Zhang, Liwen, Zhou, Hang, Jiao, Yao, Liu, Jinping, Wang, Da, Li, Yajie, Avdeev, Maxim, and Shi, Siqi
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SOLID electrolytes ,MOLECULAR dynamics ,CRYSTAL symmetry ,GEOMETRIC analysis ,SUPERIONIC conductors ,ION transport (Biology) ,ION channels - Abstract
Monoclinic natrium superionic conductors (NASICON; Na3Zr2Si2PO12) are well‐known Na‐ion solid electrolytes which have been studied for 40 years. However, due to the low symmetry of the crystal structure, identifying the migration channels of monoclinic NASICON accurately still remains unsolved. Here, a cross‐verified study of Na+ diffusion pathways in monoclinic NASICON by integrating geometric analysis of channels and bottlenecks, bond‐valence energy landscapes analysis, and ab initio molecular dynamics simulations is presented. The diffusion limiting bottlenecks, the anisotropy of conductivity, and the time and temperature dependence of Na+ distribution over the channels are characterized and strategies for improving both bulk and total conductivity of monoclinic NASICON‐type solid electrolytes are proposed. This set of hierarchical ion‐transport algorithms not only shows the efficiency and practicality in revealing the ion transport behavior in monoclinic NASICON‐type materials but also provides guidelines for optimizing their conductive properties that can be readily extended to other solid electrolytes. [ABSTRACT FROM AUTHOR]
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- 2021
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24. SoxC is Required for Ecdysteroid Induction of Neuropeptide Genes During Insect Eclosion.
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Luo GH, Chen XE, Jiao YY, Zhu GH, Zhang R, Dhandapani RK, Fang JC, and Palli SR
- Abstract
In insects, the shedding of the old exoskeleton is accomplished through ecdysis which is typically followed by the expansion and tanning of the new cuticle. Four neuropeptides, eclosion hormone (EH), ecdysis triggering hormone (ETH), crustacean cardioactive peptide (CCAP) and bursicon (Bur) are known to control ecdysis. However, the regulation of these neuropeptide genes is still poorly understood. Here, we report that in the red flour beetle (RFB) Tribolium castaneum and the fall armyworm (FAW) Spodoptera frugiperda , knockdown or knockout of the SoxC gene caused eclosion defects. The expansion and tanning of wings were not complete. In both RFB and FAW, the knockdown or knockout of SoxC resulted in a decrease in the expression of EH gene. Electrophoretic mobility shift assays revealed that the SfSoxC protein directly binds to a motif present in the promoter of SfEH . The luciferase reporter assays in Sf9 cells confirmed these results. These data suggest that transcription factor SoxC plays a key role in ecdysteroid induction of genes coding for neuropeptides such as EH involved in the regulation of insect eclosion., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Luo, Chen, Jiao, Zhu, Zhang, Dhandapani, Fang and Palli.)
- Published
- 2022
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