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1. Thymic Volume Predicts CD4 T-Cell Decline in HIV-Infected Adults Under Prolonged Treatment Interruption.

Author

Molina-Pinelo, Sonia, Vivancos, Jorge, De Felipe, Beatriz, Soriano-Sarabia, Natalia, Valladares, Angela, De la Rosa, Rafael, Vallejo, Alejandro, and Leal, Manuel

Subjects
*CD4 antigen, *T cells, *IMMUNOLOGY, *HIV-positive persons, *HIV infections, *MULTIVARIATE analysis, *REGRESSION analysis
Abstract

The article analyzes the predictive capacity of thymic volume in CD4 T-cell loss after prolonged treatment interruption in a group of immunologically preserved HIV-infected patients with nadir CD4 count greater than 250 cells/µL. Multivariate Cox proportional hazards regression models were used to analyze all variables with statistical association with CD4 T-cell loss. Twenty-three percent of the patients had a reduction in CD4 count to less than 350 cells/µL. Thymic volume and CD4 T-cell loss were independently associated using the model.

Published
2006
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