8 results on '"Xianying, Lei"'
Search Results
2. Prudence required when implementing prone position ventilation in patients with severe thrombocytopenia
- Author
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Songlin Wu, Yingying Zhang, Xiaolan Gao, and Xianying Lei
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Prone position ventilation ,Thrombocytopenia ,Subconjunctival bleeding ,Acute respiratory distress syndrome ,Surgery ,RD1-811 - Published
- 2024
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3. An interpretable machine learning model for predicting 28-day mortality in patients with sepsis-associated liver injury.
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Chengli Wen, Xu Zhang, Yong Li, Wanmeng Xiao, Qinxue Hu, Xianying Lei, Tao Xu, Sicheng Liang, Xiaolan Gao, Chao Zhang, Zehui Yu, and Muhan Lü
- Subjects
Medicine ,Science - Abstract
Sepsis-Associated Liver Injury (SALI) is an independent risk factor for death from sepsis. The aim of this study was to develop an interpretable machine learning model for early prediction of 28-day mortality in patients with SALI. Data from the Medical Information Mart for Intensive Care (MIMIC-IV, v2.2, MIMIC-III, v1.4) were used in this study. The study cohort from MIMIC-IV was randomized to the training set (0.7) and the internal validation set (0.3), with MIMIC-III (2001 to 2008) as external validation. The features with more than 20% missing values were deleted and the remaining features were multiple interpolated. Lasso-CV that lasso linear model with iterative fitting along a regularization path in which the best model is selected by cross-validation was used to select important features for model development. Eight machine learning models including Random Forest (RF), Logistic Regression, Decision Tree, Extreme Gradient Boost (XGBoost), K Nearest Neighbor, Support Vector Machine, Generalized Linear Models in which the best model is selected by cross-validation (CV_glmnet), and Linear Discriminant Analysis (LDA) were developed. Shapley additive interpretation (SHAP) was used to improve the interpretability of the optimal model. At last, a total of 1043 patients were included, of whom 710 were from MIMIC-IV and 333 from MIMIC-III. Twenty-four clinically relevant parameters were selected for model construction. For the prediction of 28-day mortality of SALI in the internal validation set, the area under the curve (AUC (95% CI)) of RF was 0.79 (95% CI: 0.73-0.86), and which performed the best. Compared with the traditional disease severity scores including Oxford Acute Severity of Illness Score (OASIS), Sequential Organ Failure Assessment (SOFA), Simplified Acute Physiology Score II (SAPS II), Logistic Organ Dysfunction Score (LODS), Systemic Inflammatory Response Syndrome (SIRS), and Acute Physiology Score III (APS III), RF also had the best performance. SHAP analysis found that Urine output, Charlson Comorbidity Index (CCI), minimal Glasgow Coma Scale (GCS_min), blood urea nitrogen (BUN) and admission_age were the five most important features affecting RF model. Therefore, RF has good predictive ability for 28-day mortality prediction in SALI. Urine output, CCI, GCS_min, BUN and age at admission(admission_age) within 24 h after intensive care unit(ICU) admission contribute significantly to model prediction.
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- 2024
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- View/download PDF
4. Continuous renal replacement therapy in sepsis-associated acute kidney injury: Effects on inflammatory mediators and coagulation function
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Songlin Wu, Tao Xu, Changxue Wu, Xianying Lei, and Xiaoli Tian
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Coagulation function ,Continuous renal replacement therapy ,Inflammatory factors ,Sepsis ,Therapeutic effect ,Surgery ,RD1-811 - Abstract
Background: To explore the effect of continuous renal replacement therapy (CRRT) in patients with sepsis-associated acute kidney injury (SA-AKI) with the Acute Kidney Injury Network Classification III and its effect on inflammatory mediators and coagulation function. Methods: We evaluated 90 patients who were diagnosed with sepsis and treated at our hospital. Forty patients received CRRT (group A) and the remainder received routine therapy (group B). We compared the renal function indices, represented by blood urea nitrogen (BUN) and serum creatinine (Scr), the urinary levels of kidney injury molecule 1, and the curative effect indices between the two groups. The incidence of major adverse cardiovascular events was compared between both groups. Further, the therapeutic effect (total effective rate) was evaluated and compared. Results: After treatment, the levels of BUN and Scr in group A were significantly lower than those in group B (p
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- 2021
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5. Pentagalloyl Glucose: A Review of Anticancer Properties, Molecular Targets, Mechanisms of Action, Pharmacokinetics, and Safety Profile
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Chengli Wen, Nathupakorn Dechsupa, Zehui Yu, Xu Zhang, Sicheng Liang, Xianying Lei, Tao Xu, Xiaolan Gao, Qinxue Hu, Phattarawadee Innuan, Jiraporn Kantapan, and Muhan Lü
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pentagalloyl glucose ,gallotannin ,anticancer ,molecular targets ,mechanisms ,pharmacokinetics ,Organic chemistry ,QD241-441 - Abstract
Pentagalloyl glucose (PGG) is a natural hydrolyzable gallotannin abundant in various plants and herbs. It has a broad range of biological activities, specifically anticancer activities, and numerous molecular targets. Despite multiple studies available on the pharmacological action of PGG, the molecular mechanisms underlying the anticancer effects of PGG are unclear. Here, we have critically reviewed the natural sources of PGG, its anticancer properties, and underlying mechanisms of action. We found that multiple natural sources of PGG are available, and the existing production technology is sufficient to produce large quantities of the required product. Three plants (or their parts) with maximum PGG content were Rhus chinensis Mill, Bouea macrophylla seed, and Mangifera indica kernel. PGG acts on multiple molecular targets and signaling pathways associated with the hallmarks of cancer to inhibit growth, angiogenesis, and metastasis of several cancers. Moreover, PGG can enhance the efficacy of chemotherapy and radiotherapy by modulating various cancer-associated pathways. Therefore, PGG can be used for treating different human cancers; nevertheless, the data on the pharmacokinetics and safety profile of PGG are limited, and further studies are essential to define the clinical use of PGG in cancer therapies.
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- 2023
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6. Continuous renal replacement therapy in sepsis-associated acute kidney injury: Effects on inflammatory mediators and coagulation function
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Tao Xu, Xiaoli Tian, Songlin Wu, Changxue Wu, and Xianying Lei
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medicine.medical_specialty ,Continuous renal replacement therapy ,RD1-811 ,medicine.medical_treatment ,Renal function ,Gastroenterology ,Group B ,Sepsis ,chemistry.chemical_compound ,Internal medicine ,Medicine ,Humans ,Renal replacement therapy ,Blood urea nitrogen ,Retrospective Studies ,Creatinine ,urogenital system ,business.industry ,Therapeutic effect ,Acute kidney injury ,Acute Kidney Injury ,medicine.disease ,Renal Replacement Therapy ,chemistry ,Inflammatory factors ,Coagulation function ,Surgery ,Inflammation Mediators ,business - Abstract
Background: To explore the effect of continuous renal replacement therapy (CRRT) in patients with sepsis-associated acute kidney injury (SA-AKI) with the Acute Kidney Injury Network Classification III and its effect on inflammatory mediators and coagulation function. Methods: We evaluated 90 patients who were diagnosed with sepsis and treated at our hospital. Forty patients received CRRT (group A) and the remainder received routine therapy (group B). We compared the renal function indices, represented by blood urea nitrogen (BUN) and serum creatinine (Scr), the urinary levels of kidney injury molecule 1, and the curative effect indices between the two groups. The incidence of major adverse cardiovascular events was compared between both groups. Further, the therapeutic effect (total effective rate) was evaluated and compared. Results: After treatment, the levels of BUN and Scr in group A were significantly lower than those in group B (p
- Published
- 2021
7. Advances in CD247.
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Dexiu, Chen, Xianying, Lei, Yingchun, Hu, and Jiafu, Li
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T cells , *AUTOIMMUNE diseases , *PEPTIDES - Abstract
CD247, which is also known as CD3ζ, CD3H, CD3Q, CD3Z, IMD25, T3Z and TCRZ, encodes CD3ζ protein, which is expressed primarily in natural killer (NK) and T cells. Since the discovery of the ζ peptide in 1986, it has been continuously investigated. In this paper, we review the composition, molecular mechanisms and regulatory factors of CD247 expression in T cells; and review the autoimmune diseases, tumours and inflammatory diseases associated with CD247, providing a detailed and comprehensive reference for further research on the mechanism of CD247 and related diseases. [ABSTRACT FROM AUTHOR]
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- 2022
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8. Critical Care for Severe COVID-19: A Population-based Study from a Province with Low Case-fatality Rate in China
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Weimin Li, Maojuan Wang, Xiangde Zhen, Rui Shi, Qin Wu, Bingxing Shuai, Min Yang, Yu Gong, Xianying Lei, Huaqiang Shen, Chang Liu, Yongming Tian, Sheng Lv, Jie Yang, Wanhong Yin, Wei Zhang, Xiong Yang, Jin Tang, Xiaodong Jin, Zhen Li, Yuanjun Zhang, Bo Wang, Hailong Wei, Huan Liu, Jian Wang, Juan Shang, Yan Kang, Hong Chen, Xiaoqi Xie, Li Chen, Chao Jia, Wen Wang, Zongan Liang, Jin Yang, Xiangrong Song, Zhongwei Zhang, Xianhua Xiao, and Xuelian Liao
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Mechanical ventilation ,education.field_of_study ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,medicine.medical_treatment ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Population ,Clinical course ,medicine.disease_cause ,Population based study ,Informed consent ,Oxygen therapy ,Emergency medicine ,Case fatality rate ,medicine ,education ,business ,China ,Nasal cannula ,Cohort study - Abstract
Background: Data regarding critical care for patients with severe COVID-19 are limited. We aimed to describe and analyse the clinical course, multi-strategy management, and respiratory support usage for the severe COVID-19 at the provincial level. Methods: Using data from Sichuan Provincial Department of Health and the population-based multicentre cohort study, all microbiologically confirmed COVID-19 patients in Sichuan who met the national severe criteria were included from January 16 to March 15, 2020. All patients were followed-up from the day of inclusion, noted as Day one (D1), until discharge, death, or the end of the study. Findings: Out of 539 COVID-19 patients, 81 severe cases (15·0%) were identified. The median (IQR) age was 50 (39-65) years, 37% were female, and 53·1% had chronic comorbidities. All severe cases were identified before requiring mechanical ventilation. Among the five predefined criteria for severe illness, low PaO2:FiO2 ratio (
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- 2020
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