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Purpose: The explore the added value of peri-calcification regions on contrast-enhanced mammography (CEM) in the differential diagnosis of breast lesions presenting as only calcification on routine mammogram., Methods: Patients who underwent CEM because of suspicious calcification-only lesions were included. The test set included patients between March 2017 and March 2019, while the validation set was collected between April 2019 and October 2019. The calcifications were automatically detected and grouped by a machine learning-based computer-aided system. In addition to extracting radiomic features on both low-energy (LE) and recombined (RC) images from the calcification areas, the peri-calcification regions, which is generated by extending the annotation margin radially with gradients from 1 mm to 9 mm, were attempted. Machine learning (ML) models were built to classify calcifications into malignant and benign groups. The diagnostic matrices were also evaluated by combing ML models with subjective reading., Results: Models for LE (significant features: wavelet-LLL&#95;glcm&#95;Imc2&#95;MLO; wavelet-HLL&#95;firstorder&#95;Entropy&#95;MLO; wavelet-LHH&#95;glcm&#95;DifferenceVariance&#95;CC; wavelet-HLL&#95;glcm&#95;SumEntropy&#95;MLO;wavelet-HLH&#95;glrlm&#95;ShortRunLowGray LevelEmphasis&#95;MLO; original&#95;firstorder&#95;Entropy&#95;MLO; original&#95;shape&#95;Elongation&#95;MLO) and RC (significant features: wavelet-HLH&#95;glszm&#95;GrayLevelNonUniformityNormalized&#95;MLO; wavelet-LLH&#95;firstorder&#95;10Percentile&#95;CC; original&#95;firstorder&#95;Maximum&#95;MLO; wavelet-HHH&#95;glcm&#95;Autocorrelation&#95;MLO; original&#95;shape&#95;Elongation&#95;MLO; wavelet-LHL&#95;glszm&#95;GrayLevelNonUniformityNormalized&#95;MLO; wavelet-LLH&#95;firstorder&#95;RootMeanSquared&#95;MLO) images were set up with 7 features. Areas under the curve (AUCs) of RC models are significantly better than those of LE models with compact and expanded boundary (RC v.s. LE, compact: 0.81 v.s. 0.73, p < 0.05; expanded: 0.89 v.s. 0.81, p < 0.05) and RC models with 3 mm boundary extension yielded the best performance compared to those with other sizes (AUC = 0.89). Combining with radiologists' reading, the 3mm-boundary RC model achieved a sensitivity of 0.871 and negative predictive value of 0.937 with similar accuracy of 0.843 in predicting malignancy., Conclusions: The machine learning model integrating intra- and peri-calcification regions on CEM has the potential to aid radiologists' performance in predicting malignancy of suspicious breast calcifications.

DNA 4 mC plays a crucial role in the genetic expression process of organisms. However, existing deep learning algorithms have shortcomings in the ability to represent DNA sequence features. In this paper, we propose a 4 mC site identification algorithm, DNABert-4mC, based on a fusion of the pruned pre-training DNABert-Pruning model and artificial feature encoding to identify 4 mC sites. The algorithm prunes and compresses the DNABert model, resulting in the pruned pre-training model DNABert-Pruning. This model reduces the number of parameters and removes redundancy from output features, yielding more precise feature representations while upholding accuracy.Simultaneously, the algorithm constructs an artificial feature encoding module to assist the DNABert-Pruning model in feature representation, effectively supplementing the information that is missing from the pre-trained features. The algorithm also introduces the AFF-4mC fusion strategy, which combines artificial feature encoding with the DNABert-Pruning model, to improve the feature representation capability of DNA sequences in multi-semantic spaces and better extract 4 mC sites and the distribution of nucleotide importance within the sequence. In experiments on six independent test sets, the DNABert-4mC algorithm achieved an average AUC value of 93.81%, outperforming seven other advanced algorithms with improvements of 2.05%, 5.02%, 11.32%, 5.90%, 12.02%, 2.42% and 2.34%, respectively. [Display omitted] • Train a new pruning pretraining model on DNA sequences to extract feature information. • The introduction of manually assisted features has expanded the search space for sequence feature. • Attention fusion strategy better promotes the fusion output of features from different dimensions. • The complementary nature of machine features and manual features better fits the target features. [ABSTRACT FROM AUTHOR]

Experiences of childhood trauma (CT) would lead to serious mental problems, especially depression. Therefore, it becomes crucial to identify influential factors related to depression and explore their associations. The objectives were to 1) identify critical depression-related factors using the extreme gradient boosting (XGBoost) method from a large-scale survey data; 2) explore associations between these factors for targeted interventions and treatments. A large-scale epidemiological study covering 63 universities was conducted in Jilin Province, China. The XGBoost model was trained and tested to classify young adults with CT experiences who had or did not have depression (N = 27,671). The essential factors were selected by SHapley Additive exPlanations (SHAP) value. Multiple logistic regression analyses were conducted for validation. The associations between these depression-related factors were further explored using network analysis. The XGBoost model selected the top 10 features associated with depression with satisfactory performance (AUC = 0.91; sensitivity = 0.88 and specificity = 0.76). These factors significantly differed between depression and non-depression groups (p < 0.001). There are strong positive associations between anxiety and obsessive-compulsive disorder (OCD), anxiety and post-traumatic stress disorder (PTSD), social anxiety disorder (SAD) and appearance anxiety, and negative associations between sleep quality and anxiety, sleep quality and PTSD among CT participants with depression. The cross-sectional design cannot draw causality, and biases in self-report measurements cannot be ignored. XGBoost model and network analysis were useful methods for discovering and understanding depression-related factors in this epidemiological study. Moreover, these essential factors could offer insights into future interventions and treatments for depressed young adults with CT experiences. • The XGBoost model identified the top 10 depression-related factors, including anxiety, sleep quality, PTSD, loneliness, and OCD, among others. • These selected factors exhibited variations between the depression and non-depression groups. • Specifically, anxiety emerged as the leading risk factor for depression. • Furthermore, among CT participants with depression, strong positive associations were observed between anxiety, OCD, PTSD, and SAD. [ABSTRACT FROM AUTHOR]