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This paper analyses the effects of Swiss agricultural policy reforms and the effects of farm income, off-farm income and direct payments on the distribution of the farm household income. To this end, the farm-level income records from the FADN data for the period 1990-2009 are used to calculate Gini coefficients and Gini elasticities. Bootstrap sampling procedures are applied to test for significant differences of the estimated parameters over time. The Gini coefficients estimated in our analysis show that the household income inequality in Swiss agriculture only slightly increased from 0.21 to 0.24, but the farm income inequality strongly increased from 0.27 to 0.38 in the considered period. We find furthermore that increasing off-farm incomes and direct payments would decrease the household income inequality. Especially direct payments that support farmers producing under adverse production conditions in the hill and mountain regions have found to be well targeted and thus contribute to the reductions in income inequality in agriculture. [ABSTRACT FROM AUTHOR]

In this paper the author explores the concepts of public regulations in regard to land use and real property ownership. The results are used to develop a theoretical, conceptual model for public regulations influencing the landowners' use of the real property. The proposed classification aims at being independent of the legal systems they are created in and are intended to be used for classification of public regulations internationally. The purpose is to establish a terminological framework for international exchange of public regulation information. The development of the public regulation model is exemplified with Swedish public regulations influencing the owner's right to use his/her real property. [ABSTRACT FROM AUTHOR]

The Facility for Anti-proton and Ion Research (FAIR), under development at GSI, includes the synchrotron SIS300, so called because the magnetic rigidity is 300 Tm. In order to reach the required high intensities of proton and heavy ions beams, the bending dipole magnets have to be pulsed from the injection magnetic field of 1.5 T up to 4.5 T maximum field at the rate of 1 T/s. These 7.8 m long magnets have \cos\theta shaped coils with a 100 mm bore and the particular characteristic to be geometrically curved, with a sagitta of 112.9 mm. These challenging requirements triggered R&D activities, aimed at the development of suitable construction technologies for fast ramped curved coils. The heart of the R&D program is the construction of a 3.9 m long model. The paper discusses the main problems faced during the design and the construction of the cold mass, mainly covering the aspects related to the manufacture. [ABSTRACT FROM AUTHOR]

The hardware commissioning of the Large Hadron Collider required the testing and the qualification of the cryogenic and vacuum system, as well as the electrical systems for the powering of more than 10 000 superconducting magnets. Nonconformities had to be resolved within a tight schedule. In this paper, we focus on the role that electromagnetic-field computation has played during hardware commissioning in terms of the analysis of a magnet quench and electromagnetic-force calculations in busbars and splices, as well as field-quality prediction for the optimization of powering cycles. [ABSTRACT FROM AUTHOR]

This paper describes aerosol modelling in Europe with a focus on Switzerland during summer and winter periods. We modelled PM2.5 (particles smaller than 2.5 µm in aerodynamic diameter) for one summer and two winter periods in years 2006 and 2007 using the CAMx air quality model. The meteorological fields were obtained from MM5 simulations. The modelled wind speeds during some lowwind periods, however, had to be calibrated with measurements to use realistic input for the air quality model. The detailed AMS (aerosol mass spectrometer) measurements at specific locations were used to evaluate the model results. In addition to the base case simulations, we carried out sensitivity tests with modified aerosol precursor emissions, air temperature and deposition. Aerosol concentrations in winter 2006 were twice as high as those in winter 2007, however, the chemical compositions were similar. CAMx could reproduce the relative composition of aerosols very well both in the winter and summer periods. Absolute concentrations of aerosol species were underestimated by about 20 %. Both measurements and model results suggest that organic aerosol (30-38 %) and particulate nitrate (30-36 %) are the main aerosol components in winter. In summer, organic aerosol dominates the aerosol composition (55-57 %) and is mainly of secondary origin. The contribution of biogenic volatile organic compound (BVOC) emissions to the formation of secondary organic aerosol (SOA) was predicted to be very large (>95 %) in Switzerland. The main contributors to the modelled SOA concentrations were oxidation products of monoterpenes and sesquiterpenes as well as oligomerization of oxidized compounds. The fraction of primary organic aerosol (POA) derived from measurements was lower than the model predictions indicating the importance of volatility of POA, which has not yet been taken into account in CAMx. Sensitivity tests with reduced NOx and NH3 emissions suggest that aerosol formation is more sensitive to ammonia emissions in winter in a large part of Europe. In Switzerland however, aerosol formation is predicted to be NOx-sensitive. In summer, effects of NOx and NH3 emission reductions on aerosol concentrations are predicted to be lower mostly due to lower ammonium nitrate concentrations. In general, the sensitivity to NH3 emissions is weaker in summer due to higher NH3 emissions. [ABSTRACT FROM AUTHOR]

Within the framework of this study we identify mesoscale catchments in Switzerland that exhibit sensitivity towards a change in climate with a focus on alterations of the water balance and peak flow conditions. For this study, the hydrological modelling system PREVAH is used, which is a semi-distributed and conceptual yet process-oriented model forced with hourly meteorological input on basis of a spatial resolution of 500x500m². We calibrate the model where measured discharge records are available and transfer the calibrated model parameters to ungauged catchments through regionalisation, to arrive at a comprehensive set of model parameters for the entire area of Switzerland. To assess future changes, we apply an extensive set of 16 Regional Climate Models (RCMs) to the catchments. The RCM data are downscaled to a dense network of meteorological stations for the period from 2021 to 2050 using the Delta Change Approach. This downscaling method incorporates a bias correction of the RCM output and provides change rates and values for precipitation and temperature. In the present paper we describe the application of a calibration and regionalisation procedure developed previously for Northern Alpine catchments to Southern catchments. The necessity to differentiate between a Northern and a Southern Alpine region, with their distinct climatologic and physiogeographic features, has proved true as the calibrated parameter sets show systematic differences between those regions, e.g. for the runoff forming parameters percolation rate (PERC) or storage time for quick runoff (KOH). For the Southern Alpine area, we calibrated two thirds of the available catchments, i.e. 23 out of 36, successfully for standard and flood conditions according to a combined model score of a linear and logarithmic Nash-Sutcliffe-Efficiency (NSE, NSEln) and a mean annual volumetric deviation (VDa). The rate of successfully calibrated catchments is rather small in comparison with the results for the Northern Alpine catchments, where 140 out of 159 calibrations have been successful, and the distribution of the Southern catchments is more irregular. However, as the median NSE and NSEln as well as the range of VDa show an overall good model fit, a successful regionalisation may be expected. Next steps are the regionalisation of the Southern Alpine model parameters and the application of climate scenarios to the complete set of catchments, i.e. about 200 Swiss mesoscale catchments with an average area of 150 km2. Thus we can identify process-based relationships between climate sensitivity and catchment characteristics and provide quantitative information on future water balance and peak flow conditions of Swiss mesoscale catchments. [ABSTRACT FROM AUTHOR]

Measurements from load tests may lead to numerical models that better reflect structural behavior. This kind of system identification is not straightforward due to important uncertainties in measurement and models. Moreover, since system identification is an inverse engineering task, many models may fit measured behavior. Traditional model updating methods may not provide the correct behavioral model due to uncertainty and parameter compensation. In this paper, a multimodel approach that explicitly incorporates uncertainties and modeling assumptions is described. The approach samples thousands of models starting from a general parametrized finite-element model. The population of selected candidate models may be used to understand and predict behavior, thereby improving structural management decision making. This approach is applied to measurements from structural performance monitoring of the Langensand Bridge in Lucerne, Switzerland. Predictions from the set of candidate models are homogenous and show an average discrepancy of 4-7% from the displacement measurements. The tests demonstrate the applicability of the multimodel approach for the structural identification and performance monitoring of real structures. The multimodel approach reveals that the Langensand Bridge has a reserve capacity of 30% with respect to serviceability requirements. [ABSTRACT FROM AUTHOR]

This paper applies some traditional management science tools to the study of Switzerland—a small country characterized by the openness of its politico-economic system to the outside world. Despite its apparent vulnerability to external influences, Switzerland has been able to maintain a remarkable degree of stability throughout the political and economic difficulties of the 1970's and 1980's, in order to help understand the main elements of this ability to absorb major international fluctuations as well as provide decision-makers with ways to analyze them and to investigate the impact of other possible developments, a simulation model of Switzerland has been constructed. This model (SIMSWISS) is based on a representation of the most important sectors of the Swiss politico-economic system, with special emphasis on their connections to the outside. SIMSWISS is constructed via a combination of dynamic simulation and optimization techniques which allow its user to check its accuracy as a representation of reality and to engage in the analysis of possible scenarios and alternative policies. An energy crisis scenario is used to illustrate how the model works and how it can be used to understand the functioning of the Swiss politico-economic system. We hope that this model will serve as the basis for a broader use of management science techniques in the study of other politico-economic systems. [ABSTRACT FROM AUTHOR]

Background: Measuring work-related stress in a reliable way is important in the development of appropriate prevention and intervention strategies. Especially in multilingual studies the use of comparable and reliable instruments is crucial. Therefore, the aim of this study was to translate selected scales and single items from the German version of the Copenhagen Psychosocial Questionnaire (COPSOQ) into French and Italian and psychometrically test them in a sample of health professionals.Methods: This study used cross-sectional data from health professionals at 163 randomised selected health organisations in Switzerland. Selected COPSOQ items/scales were backwards- and forwards- translated and cross-culturally adapted from German to French and Italian. Reliability was assessed with Cronbach alpha and intraclass correlation coefficients, construct validity with confirmatory factor analysis (CFA) and structural equation modelling as well as comparative fit index.Results: Responses from 12,754 health professionals were included in the analysis. Of the overall 24 scales, 20 in the German version, 19 in the French version and 17 in the Italian version attained sufficient internal consistency with a threshold of 0.7 for Cronbach's alpha. Predominantly high factor loadings on scale level are reported (> 0.35), as well as good and satisfactory fit values with RMSEA below 0.1, SRMR below 0.08 and CFI above 0.95. For 10 out of 15 scales, the test for factor invariance revealed a significant difference regarding the psychological constructs of the scales across the language versions.Conclusions: The psychometric properties verify the underlying theoretical model of the COPSOQ questionnaire, which is to some extent comparable across the three language versions. Of the 10 scales with significant factor variance, four showed large differences, implying that revision is needed for better comparability. Potential cultural issues as well as regional differences may have led to the factor variance and the different reliability scores per scale across language versions. One known influencing factor for regional differences is culture, which should be considered in scale development. Moreover, emerging topics such as digitization should be considered in further development of the questionnaire. [ABSTRACT FROM AUTHOR]

To facilitate evaluation of complex, organisational health interventions (OHIs), this paper aims at developing a context, process, and outcome (CPO) evaluation model. It builds on previous model developments in the field and advances them by clearly defining and relating generic evaluation categories for OHIs. Context is defined as the underlying frame that influences and is influenced by an OHI. It is further differentiated into the omnibus and discrete contexts. Process is differentiated into the implementation process, as the time-limited enactment of the original intervention plan, and the change process of individual and collective dynamics triggered by the implementation process. These processes lead to proximate, intermediate, and distal outcomes, as all results of the change process that are meaningful for various stakeholders. Research questions that might guide the evaluation of an OHI according to the CPO categories and a list of concrete themes/indicators and methods/sources applied within the evaluation of an OHI project at a hospital in Switzerland illustrate the model's applicability in structuring evaluations of complex OHIs. In conclusion, the model supplies a common language and a sharedmentalmodel for improving communication between researchers and companymembers and will improve the comparability and aggregation of evaluation study results. [ABSTRACT FROM AUTHOR]

Food systems have increasingly strong impacts on the environment, and they influence our human well‐being. In Switzerland, food consumption accounts for one‐third of the environmental impact caused by total final consumption. At the same time, non‐communicable diseases have been linked to a number of dietary aspects. In Switzerland, all non‐communicable diseases together are responsible for 80% of total public health care costs annually. Current assessments that link environmental sustainability and human health‐oriented diets for Switzerland lack a transparent representation of the dynamic effects caused by large‐scale conversions of the food system. In this study, therefore, a system dynamics model is employed to investigate intended and unintended changes on the food system structure and on environmental impacts. Several human health‐oriented scenarios are implemented and tested with different production‐ and consumption‐side intervention strategies. Because all scenarios assuming an increase in the consumption of plant‐based products also involve higher consumption of dairy products, consequences for bovine meat need to be considered. The biological link between milk and bovine meat production leads to an unintended increase in bovine meat production as milk production increases. Intervention strategies at the consumption level thus need to be accompanied by intervention strategies at the agricultural production level. Similarly, intervention strategies that aim at improving health outcomes at the production level need to be accompanied by strategies that affect diets and thus consumption preferences. Avoiding instances of policy resistance requires integrated policy design and implementation across agriculture, the environment and human health. This integration is a challenge for farmers, the food industry and consumers alike. [ABSTRACT FROM AUTHOR]

Background: Mental disorders in the perinatal period (PMD) can severely harm women and their children if not detected early and treated appropriately. Even though mental health care is covered by health insurance and is used widely by women in the perinatal period in Switzerland, it is not known if the care provided is meeting the needs of the patients and is efficient in the view of health care professionals. The aim of this study is to identify strengths, gaps and requirements for adequate mental health care in the perinatal period from the perspectives of patients and care providers for a wide range of relevant mental disorders. Methods: In the qualitative study we conduct (1) semi-structured single interviews with former PMD patients to obtain narratives about their experiences and needs for health care for their condition. Women are included who have been treated for PMD but are mentally stable at the time of the interview (n = 24). We will stratify the sample by 4 clusters of relevant ICD-10 F-diagnoses, covering the most frequent and the most severe mental disorders. We will further stratify the sample based on whether the women already had experience with psychiatric or psychological health care or not before their last episode of PMD. We will also conduct (2) three interprofessional focus groups with health and social care professionals involved in perinatal care, and a health insurance representative. The focus groups will consist of 5–8 professionals. Data collection and thematic analysis will consider Levesque's et al. (2013) conceptual model on access to health care. Discussion: The study will provide fundamental data on the experiences and perspectives about perinatal mental health care from user and provider perspectives. The study will generate the evidence base needed to develop models of integrated, coordinated, patient- and family-centred care that is accessed by women with various types of PMD. Trial registration: The study was registered on ClinicalTrials.gov in November 2019 under the identifier NCT04185896. [ABSTRACT FROM AUTHOR]

Background: Socioeconomic position (SEP) is an important contextual factor in the Stress Process Model of caregiving. However, the basic assumption that low SEP is associated with greater caregiver burden has so far lacked empirical support. The objective of this study was to investigate social inequalities in the caregiver burden among caregiving partners of persons with a physical disability, i.e., spinal cord injury (SCI), applying a dyadic approach. More specifically, we investigated 1) the association of the caregivers' SEP with caregiver burden ('actor effect'); 2) the association of the care-receivers' SEP with caregiver burden ('partner effect'), and 3) potential mediators of the association between SEP and caregiver burden. Methods: Cross-sectional survey data from 118 couples of persons with SCI and their partners living in Switzerland was used. We firstly employed logistic regression to investigate the actor and partner effects of SEP on objective (hours of caregiving) and subjective caregiver burden (Zarit Burden Interview). We additionally used structural equation modelling to explore whether unfulfilled support needs, psychosocial resources and the care-receivers health status mediated the association between SEP and caregiver burden. SEP was operationalized by household income, education, subjective social position, financial strain and home ownership. Results: We observed a consistent trend towards higher objective and subjective burden in lower SEP groups. Caregivers with higher subjective social positon and home ownership indicated lower subjective burden, and caregivers with higher education and absence of financial strain reported lower objective burden. Further evidence suggested a partner effect of SEP on caregiver burden, whereby objective caregiver burden was reduced in couples where the care-receiver had a higher educational level. The negative association between SEP and subjective burden was partially mediated by the unfulfilled support needs and deprived psychological resources of the caregiver, and the poor health status of the care-receiver. Similar mediation effects were not supported for objective burden. Conclusions: Our study, in the context of SCI, provides support for the contextual role of SEP in the Stress Process Model of caregiving. To reduce subjective caregiver burden, policy programs may target the strengthening of psychosocial resources, or the improvement of access to support services for caregivers with low SEP. [ABSTRACT FROM AUTHOR]

Fertility preservation is an increasingly important discipline. It requires close coordination between reproductive medicine specialists, reproductive biologists, and oncologists in various disciplines. In addition, it represents a particular health policy challenge, since fertility-protection measures are to be understood as a treatment for side effects of gonadotoxic treatments and would therefore normally have to be reimbursed by health insurance companies. Therefore, it is inevitable that fertility-preservation activities should organise themselves into a network structure both as a medical-logistic network and as a professional medical society. The necessary network structures can differ significantly at regional, national, and international level, as the size of the regions to be integrated and the local cultural and geographical conditions, as well as the political conditions are very different. To address these issues, the current review aims to point out the basic importance and the chances but also the difficulties of fertility-protection networks and give practical guidance for the development of such network structures. We will not only discuss network structures theoretically but also present them based on three established, different sized networks, such as the Danish Network (www.rigshospitalet.dk), representing a centralised network in a small country; the German-Austrian-Swiss network Ferti PROTEKT® (www.fertiprotekt.com), representing a centralised as well as decentralised network in a large country; and the Oncofertility® Consortium (www.oncofertility.northwestern.edu), representing a decentralised, internationally oriented network, primarily serving the transfer of knowledge among its members. [ABSTRACT FROM AUTHOR]

Background: Prediction models in autosomal dominant polycystic kidney disease (ADPKD) are useful in clinical settings to identify patients with greater risk of a rapid disease progression in whom a treatment may have more benefits than harms. Mayo Clinic investigators developed a risk prediction tool for ADPKD patients using a single kidney value. Our aim was to perform an independent geographical and temporal external validation as well as evaluate the potential for improving the predictive performance by including additional information on total kidney volume.Methods: We used data from the on-going Swiss ADPKD study from 2006 to 2016. The main analysis included a sample size of 214 patients with Typical ADPKD (Class 1). We evaluated the Mayo Clinic model performance calibration and discrimination in our external sample and assessed whether predictive performance could be improved through the addition of subsequent kidney volume measurements beyond the baseline assessment.Results: The calibration of both versions of the Mayo Clinic prediction model using continuous Height adjusted total kidney volume (HtTKV) and using risk subclasses was good, with R2 of 78% and 70%, respectively. Accuracy was also good with 91.5% and 88.7% of the predicted within 30% of the observed, respectively. Additional information regarding kidney volume did not substantially improve the model performance.Conclusion: The Mayo Clinic prediction models are generalizable to other clinical settings and provide an accurate tool based on available predictors to identify patients at high risk for rapid disease progression. [ABSTRACT FROM AUTHOR]

Background: Land Use Regression (LUR) is a popular method to explain and predict spatial contrasts in air pollution concentrations, but LUR models for ultrafine particles, such as particle number concentration (PNC) are especially scarce. Moreover, no models have been previously presented for the lung deposited surface area (LDSA) of ultrafine particles. The additional value of ultrafine particle metrics has not been well investigated due to lack of exposure measurements and models.Methods: Air pollution measurements were performed in 2011 and 2012 in the eight areas of the Swiss SAPALDIA study at up to 40 sites per area for NO2 and at 20 sites in four areas for markers of particulate air pollution. We developed multi-area LUR models for biannual average concentrations of PM2.5, PM2.5 absorbance, PM10, PMcoarse, PNC and LDSA, as well as alpine, non-alpine and study area specific models for NO2, using predictor variables which were available at a national level. Models were validated using leave-one-out cross-validation, as well as independent external validation with routine monitoring data.Results: Model explained variance (R(2)) was moderate for the various PM mass fractions PM2.5 (0.57), PM10 (0.63) and PMcoarse (0.45), and was high for PM2.5 absorbance (0.81), PNC (0.87) and LDSA (0.91). Study-area specific LUR models for NO2 (R(2) range 0.52-0.89) outperformed combined-area alpine (R (2)  = 0.53) and non-alpine (R (2)  = 0.65) models in terms of both cross-validation and independent external validation, and were better able to account for between-area variability. Predictor variables related to traffic and national dispersion model estimates were important predictors.Conclusions: LUR models for all pollutants captured spatial variability of long-term average concentrations, performed adequately in validation, and could be successfully applied to the SAPALDIA cohort. Dispersion model predictions or area indicators served well to capture the between area variance. For NO2, applying study-area specific models was preferable over applying combined-area alpine/non-alpine models. Correlations between pollutants were higher in the model predictions than in the measurements, so it will remain challenging to disentangle their health effects. [ABSTRACT FROM AUTHOR]

We consider the top forward-backward (FB) asymmetry at the Tevatron and top charge asymmetry at the LHC within chiral U(1)′ models with flavor-dependent U(1)′ charges and flavored Higgs fields, which were introduced in Ko et al. (J. High Energy Phys. 1201:147, ). In this model, one has to include the flavor-changing couplings of the Higgs bosons as well as the Z′ to the up-type quarks. The models could enhance not only the top forward-backward asymmetry at the Tevatron, but also the top charge asymmetry at LHC, without too large same-sign top-quark pair production rates. Also the $m_{t\bar{t}}$ distribution at high $m_{t\bar{t}}$ shows less deviations from the SM predictions. We identify parameter spaces for the U(1)′ gauge boson and (pseudo) scalar Higgs bosons where all the experimental data could be accommodated, including the case with about 125 GeV Higgs boson, as suggested recently by ATLAS and CMS. [ABSTRACT FROM AUTHOR]

We describe the implementation details of the colour reconnection model in the event generator Herwig++. We study the impact on final-state observables in detail and confirm the model idea from colour preconfinement on the basis of studies within the cluster hadronization model. Moreover, we show that the description of minimum bias and underlying event data at the LHC is improved with this model and present results of a tune to available data. [ABSTRACT FROM AUTHOR]

The fourth family quarks are expected to have mass larger than the top quark considering the results from recent studies on the allowed parameter space. They could also have different dynamics than the quarks of three families of the standard model. The single production of the fourth family up-type quark t' is studied via the anomalous production process pp→t'VX (where V = g, Z, γ ) at the LHC with the center of mass energy of 7 and 14 TeV. The signatures of such process are discussed within both the SM and the anomalous decay modes of t' quarks. The sensitivity to anomalous coupling κ/&Lgr; = 0.004 TeV-1 can be reached at v s = 14 TeV and Lint = 100 pb-1. [ABSTRACT FROM AUTHOR]

Using new historical data from Swiss cantons, we estimate the effect of direct democracy on government spending. We use fixed effects to control for unobserved heterogeneity and new instruments to address potential endogeneity concerns. We find that direct democracy constrains canton spending but its effect is more modest than previously suggested. The instrumental variable estimates show that a mandatory budget referendum reduces canton expenditures by 12%. Lowering signature requirements for the voter initiative by 1% reduces canton spending by 0.6%. We find little evidence that direct democracy at the canton level results in higher local spending or decentralisation. [ABSTRACT FROM AUTHOR]

The acceptance tests of the Cable in Conduit Conductors for the Toroidal Field coils of the ITER magnet system are being performed at the SULTAN facility in Villigen, Switzerland. The main physical quantity measured in these tests is the current sharing temperature, Tcs. In Tcs measurements, the E\-T characteristic curve of the conductor is traced. This curve is utilized here to evaluate the equivalent n-index and the effective strain of the superconducting Nb3Sn cable, under the simplifying assumptions of a uniform strain, current density and temperature distribution in the cable cross section. The variations of n-index and effective strain with mechanical cycling and their sensitivity to the applied transverse load and to the warm up-cooldown process are presented for various conductor samples tested recently. [ABSTRACT FROM AUTHOR]

The ALICE and CMS data on the multiplicity distributions are compared with the lower energy data and with the results from the 8.142 version of the PYTHIA MC event generator with two tunings. The ALICE data for moments are used to calculate the factorial cumulants. It is suggested that the data on moments or cumulants are well suited to specify the optimal tuning of the model parameters. [ABSTRACT FROM AUTHOR]

The article presents a research study which deals the performance of Enercon E-82 wind turbines with icing on their structures in Jura, Switzerland. Researchers have used accretion model with mesoscale weather forecast model to determine the behavior and performance of these turbines. Researchers found out the icing's impact on turbines' performance and power production.

Background: What constitutes best practice in the area of intersex, renamed Disorders/differences of sex development (DSD/dsd) or even variations of sex development (VDS) after the ‘‘Chicago consensus’’? What kind of model of care would meet the requirements of an ethical management of intersex/dsd/VDS? Methods: In 2005, we launched an interdisciplinary SHS and gender medicine project to improve the standards of care for persons with intersex/dsd/VDS. Abroad, this project, initiated in Lausanne, has sometimes been called the ‘‘Swiss Model’’. It includes the development of an interdisciplinary team, based at the University hospital CHUV, who takes care of persons born with intersex/dsd/VDS and also teaches an ethical model of care to students at the Medical School of the University of Lausanne. The ‘‘Swiss Model’’ is centered on the children’s fundamental rights to bodily integrity, self-determination and genital autonomy. We describe our 10 years’ experience, the reasons, goals and development modalities of our team and model of care. Results: We have developed a medical ethics ‘‘from below’’ to overcome the lack of ethical recommendations, as it was the case until 2012 in Switzerland. During this period of time, genital surgeries and other non-vital medical treatments have been postponed until the child could fully participate in the medical decisions and give one’s informed assent or consent. Only one family did not follow our recommendations. Conclusions: The Lausanne experience testifies to the possibility of changing the so-called Johns Hopkins paradigm in actual practice. The model of care we have implemented can define best practice as it is scientifically grounded, medically reasonable, and ethically consistent. [ABSTRACT FROM AUTHOR]

In Summer 2002 eddy covariance flux measurements of CO2 were performed over a dense urban surface. The month-long measurements were carried out in the framework of the Basel Urban Boundary Layer Experiment (BUBBLE). Two Li7500 open path analysers were installed at z/z H = 1.0 and 2.2 above a street canyon with z H the average building height of 14.6 m and z the height above street level. Additionally, profiles of CO2 concentration were sampled at 10 heights from street level up to 2 z H . The minimum and maximum of the average diurnal course of CO2 concentration at 2 z H were 362 and 423 ppmv in late afternoon and early morning, respectively. Daytime CO2 concentrations were not correlated to local sources, e.g. the minimum occurred together with the maximum in traffic load. During night-time CO2 is in general accumulated, except when inversion development is suppressed by frontal passages. CO2 concentrations were always decreasing with height and correspondingly, the fluxes – on average – always directed upward. At z/z H = 2.2 low values of about 3 µmol m−2 s−1 were measured during the second half of the night. During daytime average values reached up to 14 µmol m−2 s−1. The CO2 fluxes are well correlated with the traffic load, with their maxima occurring together in late afternoon. Daytime minimum CO2 concentrations fell below regional background values. Besides vertical mixing and entrainment, it is suggested that this is also due to advection of rural air with reduced CO2 concentration. Comparison with other urban observations shows a large range of differences among urban sites in terms of both CO2 fluxes and concentrations. [ABSTRACT FROM AUTHOR]

Reconciling the differential perspective with the Piagetian perspective is a very difficult task. The Piagetian perspective admits the existence of interindividual differences but interprets them as noise masking the universal logical succession of structures, whereas the differential perspective views development as consisting of "vicarious processes." As a matter of historical fact, the main aim of the "procedural studies" carried out in Geneva was to introduce concrete microgenesis into the macrogenetic Piagetian model. [ABSTRACT FROM AUTHOR]

Faults in the host rock that might exist in the vicinity of deep geological repositories for radioactive waste, constitute potential enhanced pathways for radionuclide migration. Several processes might trigger pore pressure increases in the faults leading to fault failure and induced seismicity, and increase the faults' permeability. In this research, we developed a mathematical model to simulate fault activation during an experiment of controlled water injection in a fault at the Mont-Terri Underground Research Laboratory in Switzerland. The effects of in-situ stress, fault shear strength parameters and heterogeneity are assessed. It was shown that the above factors are critical and need to be adequately characterized in order to predict the faults' hydro-mechanical behaviour. [ABSTRACT FROM AUTHOR]

Maneuver acceleration constraints for formation flight path planning based on the leader-follower concept are proposed. First, a minimum maneuver radius is derived to restrict the excessive required velocity over the minimum or maximum value. Second, in order to prevent an abrupt velocity reduction, which may cause large formation errors, a velocity reduction slope is derived to avoid a reverse-thrust command. Finally, we propose a scheme to put these constraints on the leader's maneuver to obtain a feasible path plan for formation flight based on the leader-follower concept. [ABSTRACT FROM PUBLISHER]