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MicroRNAs (miRNAs) play a critical role in the development of cancers. However, the role of miRNAs in glioma is still poorly understood. In this study, we demonstrate that microRNA-10a (miR-10a) promotes cell migration and invasion by negatively regulating the expression of Eph tyrosine kinase receptor A8 ( EphA8 ). Ectopic expression of EphA8 counteracts the promotion of migration and invasion induced by miR-10a. We further demonstrate that miR-10a and EphA8 regulate epithelial–mesenchymal transition (EMT) to affect cell migration and invasion. Collectively, we unveil a branch of the miR-10a/ EphA8 pathway that regulates the progression of glioma. [ABSTRACT FROM AUTHOR]

Highlights: [•] miR-21 suppresses the expression of hSulf-1 and PTEN in HCC cells. [•] Suppression of hSulf-1 or PTEN by miR-21 can activate AKT/ERK1/2 signaling. [•] Activation of AKT/ERK1/2 pathways induces EMT in HCC cells. [•] miR-21 functions to promote cancer cell proliferation and movement. [Copyright &y& Elsevier]