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Your search keyword '"Manfred T. Reetz"' showing total 2 results
Start Over Author "Manfred T. Reetz" Topic enantioselective catalysis Language english
2 results on '"Manfred T. Reetz"'

1. A genetic selection system for evolving enantioselectivity of enzymes.

Author

Manfred T. Reetz, Horst Höbenreich, Pankaj Soni, and Layla Fernández

Subjects
*ENZYMES, *ORGANIC compounds, *ENANTIOSELECTIVE catalysis, *LIPASES, *HYDROLYSIS, *CHEMICAL kinetics
Abstract

As an alternative to screening in the directed evolution of enantioselective enzymes, a selection system has been implemented for a lipase-catalyzed hydrolytic kinetic resolution of a chiral ester. [ABSTRACT FROM AUTHOR]

Published
2008
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2. Greatly reduced amino acid alphabets in directed evolution: making the right choice for saturation mutagenesis at homologous enzyme positions.

Author

Manfred T. Reetz and Sheng Wu

Subjects
*AMINO acids, *MUTAGENESIS, *RADIOGENETICS, *ENANTIOSELECTIVE catalysis, *MONOOXYGENASES, *CHEMICAL reactions
Abstract

Enantioselective mutants of the thermally robust phenyl acetone monooxygenase (PAMO) as catalysts in Baeyer–Villiger reactions have been evolved by utilizing saturation mutagenesis in which drastically reduced amino acid alphabets are employed at homologous enzyme positions. [ABSTRACT FROM AUTHOR]

Published
2008
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