1. Inhibition of Mast Cell-Dependent Allergy Reaction by Extract of Black Cohosh (Cimicifuga racemosa).
- Author
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Kim, Chang Deok, Lee, Won‐Kyung, Lee, Min‐Ho, Cho, Ho Song, Lee, Yong Koo, and Roh, Seok‐Seon
- Subjects
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MAST cell disease , *ALLERGIES , *BUGBANE , *LYMPH nodes , *INFLAMMATION , *MESSENGER RNA - Abstract
Black cohosh (Cimiciffuga racemosa) has been used as therapeutics for pain and inflammation in Korean folk medicine. The potential effects of black cohosh extract (BCE) on mast cell-dependent allergy reaction, however, have not been well elucidated yet. In the present study, we investigated the effect of BCE on the allergy reaction using mast cell-dependent in vivo and in vitro models. BCE showed no potential of skin sensitization in local lymph node assay (LLNA). The oral administration of BCE significantly inhibited the anti-IgE-induced passive cutaneous anaphylaxis (PCA) reaction. BCE also showed inhibitory potential on the compound 48/80-induced histamine release from rat peritoneal mast cells. In addition, BCE inhibited the IL-4, IL-5 and TNF-α mRNA induction by PMA and A23187 in human leukemia mast cells, HMC-1. These results demonstrated that BCE has an anti-allergic potential and it may be due to the inhibition of histamine release and cytokine gene expression in the mast cells. [ABSTRACT FROM AUTHOR]
- Published
- 2004
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