1. 24-h Intraocular pressure control with evening-dosed travoprost/timolol, compared with latanoprost/timolol, fixed combinations in exfoliative glaucoma.
- Author
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Konstas AG, Mikropoulos DG, Embeslidis TA, Dimopoulos AT, Papanastasiou A, Haidich AB, and Stewart WC
- Subjects
- Aged, Cloprostenol therapeutic use, Cross-Over Studies, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Latanoprost, Male, Middle Aged, Prospective Studies, Single-Blind Method, Time Factors, Travoprost, Antihypertensive Agents therapeutic use, Cloprostenol analogs & derivatives, Exfoliation Syndrome drug therapy, Glaucoma drug therapy, Intraocular Pressure drug effects, Prostaglandins F, Synthetic therapeutic use, Timolol therapeutic use
- Abstract
Purpose: To evaluate 24-h efficacy of travoprost/timolol fixed combination (TTFC) vslatanoprost/timolol fixed combination (LTFC) in exfoliative glaucoma (XFG)., Design: A prospective, single-masked, crossover, active-controlled, randomized 24-h comparison., Methods: After up to a 6-week medicine-free period, XFG patients were randomized to either TTFC or LTFC for 3 months, dosed each evening, and then changed to the opposite treatment for another 3 months. At the end of the washout, and both treatment periods, a 24-h intraocular pressure (IOP) curve was measured., Results: In total, 40 patients completed the study. The TTFC group showed a lower mean absolute 24-h IOP (18.7±2.6 vs 19.6±2.6 mm Hg, P<0.001), maximum IOP (20.5±2.6 vs 21.5±2.6 mm Hg, P<0.001) and 24-h IOP range (3.4±1.3 vs 4.1±1.6 mm Hg, P=0.01). At individual time points, TTFC showed reduced IOPs compared with LTFC, after a Bonferroni correction, at 1000, 1800, and 2200 hours (P≤0.04). No statistical differences existed at hours: 0600, 1400, and 0200 (P≥0.05) and for the minimum IOP (P=0.09)., Conclusions: This study suggests that evening-dosed TTFC may provide greater 24-h IOP reduction, primarily at the 1800 hours time point, compared with LTFC in XFG.
- Published
- 2010
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