356 results on '"Julvez, Jordi"'
Search Results
52. The association between maternal ultra-processed food consumption during pregnancy and child neuropsychological development: A population-based birth cohort study.
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Puig-Vallverdú, Júlia, Romaguera, Dora, Fernández-Barrés, Sílvia, Gignac, Florence, Ibarluzea, Jesús, Santa-Maria, Loreto, Llop, Sabrina, Gonzalez, Sandra, Vioque, Jesús, Riaño-Galán, Isolina, Fernández-Tardón, Guillermo, Pinar, Ariadna, Turner, Michelle C., Arija, Victoria, Salas-Savadó, Jordi, Vrijheid, Martine, and Julvez, Jordi
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- 2022
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53. Arsenic exposure and respiratory outcomes during childhood in the INMA study.
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Signes-Pastor, Antonio J., Díaz-Coto, Susana, Martinez-Camblor, Pablo, Carey, Manus, Soler-Blasco, Raquel, García-Villarino, Miguel, Fernández-Somoano, Ana, Julvez, Jordi, Carrasco, Paula, Lertxundi, Aitana, Santa Marina, Loreto, Casas, Maribel, Meharg, Andrew A., Karagas, Margaret R., and Vioque-Lopez, Jesús
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SEAFOOD ,POISSON regression ,ARSENIC ,GENERALIZED estimating equations ,CACODYLIC acid ,SPLINES - Abstract
Ingested inorganic arsenic (iAs) is a human carcinogen that is also linked to other adverse health effects, such as respiratory outcomes. Yet, among populations consuming low-arsenic drinking water, the impact of iAs exposure on childhood respiratory health is still uncertain. For a Spanish child study cohort (INfancia y Medio Ambiente—INMA), low-arsenic drinking water is usually available and ingestion of iAs from food is considered the major source of exposure. Here, we explored the association between iAs exposure and children's respiratory outcomes assessed at 4 and 7 years of age (n = 400). The summation of 4-year-old children's urinary iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) was used as a biomarker of iAs exposure (∑As) (median of 4.92 μg/L). Children's occurrence of asthma, eczema, sneeze, wheeze, and medication for asthma and wheeze at each assessment time point (i.e., 4- and 7-year) was assessed with maternal interviewer-led questionnaires. Crude and adjusted Poisson regression models using Generalized Estimating Equation (GEE) were performed to account for the association between natural logarithm transformed (ln) urinary ∑As in μg/L at 4 years and repeated assessments of respiratory symptoms at 4 and 7 years of age. The covariates included in the models were child sex, maternal smoking status, maternal level of education, sub-cohort, and children's consumption of vegetables, fruits, and fish/seafood. The GEE—splines function using Poisson regression showed an increased trend of the overall expected counts of respiratory symptoms with high urinary ∑As. The adjusted expected counts (95% confidence intervals) at ln-transformed urinary ∑As 1.57 (average concentration) and 4.00 (99
th percentile concentration) were 0.63 (0.36, 1.10) and 1.33 (0.61, 2.89), respectively. These exploratory findings suggest that even relatively low-iAs exposure levels, relevant to the Spanish and other populations, may relate to an increased number of respiratory symptoms during childhood. [ABSTRACT FROM AUTHOR]- Published
- 2022
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54. Exposure to bisphenol A during pregnancy and child neuropsychological development in the INMA-Sabadell cohort
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Casas, Maribel, Forns, Joan, Martínez, David, Avella-García, Claudia, Valvi, Damaskini, Ballesteros-Gómez, Ana, Luque, Noelia, Rubio, Soledad, Julvez, Jordi, Sunyer, Jordi, and Vrijheid, Martine
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- 2015
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55. Prenatal exposure to mirex impairs neurodevelopment at age of 4 years
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Puertas, Raquel, Lopez-Espinosa, Maria-Jose, Cruz, Francisco, Ramos, Rosa, Freire, Carmen, Pérez-García, Miguel, Abril, Ana, Julvez, Jordi, Salvatierra, Maite, Campoy, Cristina, and Olea, Nicolas
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- 2010
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56. Corrigendum to “Television viewing duration during childhood and long-association with adolescent neuropsychological outcomes” [Prev. Med. Rep. 4 (2016) 447–452.]
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O'Connor, Giselle, Piñero Casas, Maria, Basagaña, Xavier, López Vicente, Mònica, Davand, Payam, Torrent, Maties, Martínez-Murciano, David, García-Esteban, Raquel, Marinelli, Marcella, Sunyer, Jordi, and Julvez, Jordi
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- 2021
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57. A Birth Cohort Study on the Genetic Modification of the Association of Prenatal Methylmercury With Child Cognitive Development
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Julvez, Jordi, Davey Smith, George, Ring, Susan, and Grandjean, Philippe
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Male ,mercury ,cognitive functions ,Original Contributions ,Developmental Disabilities ,Wechsler Scales ,population-based birth cohort ,ALSPAC ,Methylmercury Compounds ,Polymorphism, Single Nucleotide ,Umbilical Cord ,Cohort Studies ,Child Development ,neuropsychological development ,Pregnancy ,Prenatal Exposure Delayed Effects ,Humans ,Female ,Genetic Predisposition to Disease ,pregnancy ,genes ,Child ,SNPs - Abstract
Genetic predisposition might affect neurodevelopmental outcomes of prenatal methylmercury exposure. We examined suspected heterogeneities for modification of exposure-related neurodevelopment in children from the Avon Longitudinal Study of Parents and Children (1991–2000), Bristol, United Kingdom. A subgroup (n = 1,127 from a pilot study and 1,045 from the present study) was identified based on the availability of the mercury concentration of cord tissue as a measure of prenatal methylmercury exposure, data on 247 single-nucleotide polymorphisms (SNPs), and Wechsler Intelligence Scale for Children intelligence quotient (IQ) scores. Log10-transformed mercury concentration was positively associated with IQ, but adjustment for confounding cofactors attenuated this association. A finding of enhanced interaction with methylmercury was replicated in this study for the minor allele of rs1042838 (progesterone receptor) (β = −11.8, 95% confidence interval: −23.0, −0.6; P for interaction = 0.004) and weakly for rs662 (paraoxonase 1) (β = −3.6, 95% confidence interval: −11.4, 4.3; P = 0.117). In the joint sample, new interacting single-nucleotide polymorphisms were discovered in relation to superoxide dismutase 2, ATP binding cassette subfamily A member 1, and metallothionein 1M genes. While the low-level prenatal exposure to methylmercury was not associated with child cognition, progesterone receptor rs1042838 minor alleles revealed a negative association of mercury exposure with IQ.
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- 2019
58. Synergism between exposure to mercury and use of iodine supplements on thyroid hormones in pregnant women
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Llop, Sabrina, Lopez-Espinosa, Maria-Jose, Murcia, Mario, Alvarez-Pedrerol, Mar, Vioque, Jesús, Aguinagalde, Xabier, Julvez, Jordi, Aurrekoetxea, Juan J., Espada, Mercedes, Santa-Marina, Loreto, Rebagliato, Marisa, and Ballester, Ferran
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- 2015
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59. Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts
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Jedynak, Paulina, Maitre, Léa, Guxens Junyent, Mònica, Julvez, Jordi, López Vicente, Mònica, 1988, Sunyer Deu, Jordi, Casas Sanahuja, Maribel, Tamayo-Uria, Ibon, Urquiza, José M., Basagaña Flores, Xavier, Vrijheid, Martine, and Philippat, Claire
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Child behaviour ,Prenatal exposure ,Strengths and Difficulties Questionnaire ,Internal exposome ,Birth cohort - Abstract
Background: Studies looking at associations between environmental chemicals and child behaviour usually consider only one exposure or family of exposures. Objective: This study explores associations between prenatal exposure to a wide range of environmental chemicals and child behaviour. Methods: We studied 708 mother-child pairs from five European cohorts recruited in 2003-2009. We assessed 47 exposure biomarkers from eight chemical exposure families in maternal blood or urine collected during pregnancy. We used the Strengths and Difficulties Questionnaire (SDQ) to evaluate child behaviour between three and seven years of age. We assessed associations of SDQ scores with exposures using an adjusted least absolute shrinkage and selection operator (LASSO) considering all exposures simultaneously and an adjusted exposome-wide association study (ExWAS) considering each exposure independently. Results: LASSO selected only copper (Cu) as associated with externalizing behaviour. In the ExWAS, bisphenol A [BPA, incidence rate ratio (IRR): 1.06, 95% confidence interval (95%CI): 1.01;1.12] and mono-n-butyl phthalate (MnBP, IRR: 1.06, 95%CI: 1.00;1.13) were associated with greater risk of externalizing behaviour problems. Cu (IRR: 0.90, 95%CI: 0.82;0.98), perfluoroundecanoate (PFUnDA, IRR: 0.92, 95%CI: 0.84;0.99) and organochlorine compounds (OCs) were associated with lower risk of externalizing behaviour problems, however the associations with OCs were mainly seen among women with insufficient weight gain during pregnancy. Internalizing score worsen in association with exposure to diethyl thiophosphate (DETP, IRR: 1.11, 95%CI: 1.00;1.24) but the effect was driven by the smallest cohort. Internalizing score improved with increased concentration of perfluorooctane sulfonate (PFOS, IRR: 0.92, 95%CI: 0.85;1.00), however the association was driven by the two smallest cohorts with the lowest PFOS concentrations. Discussion: This study added evidence on deleterious effects of prenatal exposure to BPA and MnBP on child behaviour. Other associations should be interpreted cautiously since they were not consistent with previous studies or they have not been studied extensively.
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- 2021
60. Association of ADHD symptoms and social competence with cognitive status in preschoolers
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Ramos, Rosa, Freire, Carmen, Julvez, Jordi, Fernández, Mariana F., García-Esteban, Raquel, Torrent, Maties, Sunyer, Jordi, and Olea, Nicolás
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- 2013
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61. The n-back Test and the Attentional Network Task as Measures of Child Neuropsychological Development in Epidemiological Studies
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Forns, Joan, Esnaola, Mikel, López-Vicente, Mónica, Suades-González, Elisabet, Alvarez-Pedrerol, Mar, Julvez, Jordi, Grellier, James, Sebastián-Gallés, Núria, and Sunyer, Jordi
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- 2014
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62. Association between Child Cortisol Levels in Saliva and Neuropsychological Development during the Second Year of Life
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Forns, Joan, Vegas, Oscar, Julvez, Jordi, Garcia-Esteban, Raquel, Rivera, Marcela, Lertxundi, Nerea, Guxens, Mònica, Fano, Eduardo, Ferrer, Muriel, Grellier, James, Ibarluzea, Jesús, and Sunyer, Jordi
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- 2014
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63. A cohort study on full breastfeeding and child neuropsychological development: the role of maternal social, psychological, and nutritional factors
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Julvez, Jordi, Guxens, Monica, Carsin, Anne-Elie, Forns, Joan, Mendez, Michelle, Turner, Michelle C, and Sunyer, Jordi
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- 2014
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64. Maternal sleep duration and neonate birth weight: A population‐based cohort study.
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Marinelli, Marcella, Carsin, Anne‐Elie, Turner, Michelle C, Fernández‐Somoano, Ana, Rodriguez‐Dehli, Ana Cristina, Basterrechea, Mikel, Santa‐Marina, Loreto, Iñiguez, Carmen, Lopez‐Espinosa, Maria‐Jose, Sunyer, Jordi, and Julvez, Jordi
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- 2022
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65. Exposure to hexachlorobenzene during pregnancy and children's social behavior at 4 years of age
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Ribas-Fito, Nuria, Torrent, Maties, Carrizo, Daniel, Julvez, Jordi, Grimalt, Joan O., and Sunyer, Jordi
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Chlorobenzene -- Complications and side effects ,Chlorobenzene -- Environmental aspects ,Pregnant women -- Health aspects ,Pregnant women -- Environmental aspects ,Children -- Psychological aspects ,Children -- Environmental aspects - Abstract
BACKGROUND: Hexachlorobenzene (HCB) is an organochlorine chemical that has been used in agriculture and industrial processes. Behavioral impairment after HCB exposure has been described in animal models, but little information [...]
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- 2007
66. Iodine Supplementation During Pregnancy and Infant Neuropsychological Development: INMA Mother and Child Cohort Study
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Rebagliato, Marisa, Murcia, Mario, Álvarez-Pedrerol, Mar, Espada, Mercedes, Fernández-Somoano, Ana, Lertxundi, Nerea, Navarrete-Muñoz, Eva-María, Forns, Joan, Aranbarri, Aritz, Llop, Sabrina, Julvez, Jordi, Tardón, Adonina, and Ballester, Ferran
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- 2013
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67. Longitudinal association between early life socio-environmental factors and attention function at the age 11 years
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Forns, Joan, Torrent, Maties, Garcia-Esteban, Raquel, Cáceres, Alejandro, Gomila, María Pilar, Martinez, David, Morales, Eva, Julvez, Jordi, Grimalt, Joan O., and Sunyer, Jordi
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- 2012
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68. Cognitive Function and Overweight in Preschool Children
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Guxens, Mònica, Mendez, Michelle A., Julvez, Jordi, Plana, Estel, Forns, Joan, Basagaña, Xavier, Torrent, Maties, and Sunyer, Jordi
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- 2009
69. GSTM1 polymorphisms modify the effect of maternal smoking during pregnancy on cognitive functioning in preschoolers
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Morales, Eva, Sunyer, Jordi, Julvez, Jordi, Castro-Giner, Francesc, Estivill, Xavier, Torrent, Maties, and De Cid, Rafael
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- 2009
70. Association of Early-life Exposure to Household Gas Appliances and Indoor Nitrogen Dioxide With Cognition and Attention Behavior in Preschoolers
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Morales, Eva, Julvez, Jordi, Torrent, Maties, de Cid, Rafael, Guxens, Mònica, Bustamante, Mariona, Künzli, Nino, and Sunyer, Jordi
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- 2009
71. Maternal use of folic acid supplements during pregnancy and four-year-old neurodevelopment in a population-based birth cohort
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Julvez, Jordi, Fortuny, Joan, Mendez, Michelle, Torrent, Maties, Ribas-Fitó, Núria, and Sunyer, Jordi
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- 2009
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72. Response to 'comment on 'exposure to road traffic noise and behavioral problems in 7-year-old children: a cohort study''
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Hjortebjerg, Dorrit, Andersen, Anne Marie Nybo, Christensen, Jeppe Schultz, Ketzel, Matthias, Raaschou-Nielsen, Ole, Sunyer, Jordi, Julvez, Jordi, Forns, Joan, and Sorensen, Mette
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Environmental issues ,Health - Abstract
Refers to http://dx.doi.org/10.1289/ehp.1409430 We agree with Lezama et al. that the mental health of a parent may influence child behavior. Several family-level factors, including poor maternal mental health, have been [...]
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- 2016
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73. Exposure to road traffic noise and behavioral problems in 7-year-old children: a cohort study
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Hjortebjerg, Dorrit, Andersen, Anne Marie Nybo, Christensen, Jeppe Schultz, Ketzel, Matthias, Raaschou-Nielsen, Ole, Sunyer, Jordi, Julvez, Jordi, Forns, Joan, and Sorensen, Mette
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Child behavior -- Abnormalities ,Medical research ,Traffic noise -- Health aspects ,Environmental health -- Research ,Environmental issues ,Health - Abstract
BACKGROUND: Exposure to traffic noise has been associated with adverse effects on neuropsychological outcomes in children, but findings with regard to behavioral problems are inconsistent. OBJECTIVE: We investigated whether residential road traffic noise exposure is associated with behavioral problems in 7-year-old children. METHODS: We identified 46,940 children from the Danish National Birth Cohort with complete information on behavioral problems at 7 years of age and complete address history from conception to 7 years of age. Road traffic noise ([L.sub.den]) was modeled at all present and historical addresses. Behavioral problems were assessed by the parent-reported Strengths and Difficulties Questionnaire (SDQ). Associations between pregnancy and childhood exposure to noise and behavioral problems were analyzed by multinomial or logistic regression and adjusted for potential confounders. RESULTS: A 10-dB increase in average time-weighted road traffic noise exposure from birth to 7 years of age was associated with a 7% increase (95% CI: 1.00, 1.14) in abnormal versus normal total difficulties scores; 5% (95% CI: 1.00, 1.10) and 9% (95% CI: 1.03, 1.18) increases in borderline and abnormal hyperactivity/inattention subscale scores, respectively; and 5% (95% CI: 0.98, 1.14) and 6% (95% CI: 0.99, 1.12) increases in abnormal conduct problem and peer relationship problem subscale scores, respectively. Exposure to road traffic noise during pregnancy was not associated with child behavioral problems at 7 years of age. CONCLUSIONS: Residential road traffic noise in early childhood may be associated with behavioral problems, particularly hyperactivity/inattention symptoms. http://dx.doi.org/10.1289/ehp.1409430, Introduction Exposure to traffic noise is considerable in many parts of the world and has been associated with health effects among adults, including psychological symptoms such as anxiety and changes [...]
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- 2016
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74. Response to commentary: maternal smoking during pregnancy—hazard for what?
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Julvez, Jordi and Sunyer, Jordi
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- 2007
75. Maternal smoking habits and cognitive development of children at age 4 years in a population-based birth cohort
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Julvez, Jordi, Ribas-Fitó, Núria, Torrent, Maties, Forns, Maria, Garcia-Esteban, Raquel, and Sunyer, Jordi
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- 2007
76. TSH concentration within the normal range is associated with cognitive function and ADHD symptoms in healthy preschoolers
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Álvarez-Pedrerol, Mar, Ribas-Fitó, Núria, Torrent, Maties, Julvez, Jordi, Ferrer, Carlos, and Sunyer, Jordi
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- 2007
77. Attention behaviour and hyperactivity at age 4 and duration of breast-feeding
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Julvez, Jordi, Ribas-Fitó, Núria, Forns, Maria, Garcia-Esteban, Raquel, Torrent, Maties, and Sunyer, Jordi
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- 2007
78. Green and blue spaces and behavioral development in Barcelona schoolchildren: the BREATHE project
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Amoly, Elmira, Dadvand, Payam, Forns, Joan, Lopez-Vicente, Monica, Basagana, Xavier, Julvez, Jordi, Alvarez-Pedrerol, Mar, Nieuwenhuijsen, Mark J., and Sunyer, Jordi
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Behavioral assessment of children -- Research ,Elementary school students -- Psychological aspects -- Physiological aspects ,Environmental issues ,Health - Abstract
BACKGROUND: Green spaces have been associated with improved mental health in children; however, available epidemiological evidence on their impact on child behavioral development is scarce. OBJECTIVES: We investigated the impact of contact with green spaces and blue spaces (beaches) on indicators of behavioral development and symptoms of attention deficit/hyperactivity disorder (ADHD) in schoolchildren. METHODS: This study was based on a sample of 2, 111 schoolchildren (7-10 years of age) from 36 schools in Barcelona in 2012. We obtained data on time spent in green spaces and beaches and Strengths and Difficulties Questionnaires (SDQ) from parents, and ADHD/DSM-IV questionnaires from teachers. Surrounding greenness was abstracted as the average Normalized Difference Vegetation Index (NDVI) in buffers of 100 m, 250 m, and 500 m around each home address. Proximity to green spaces was defined as living within 300 m of a major green space (> 0.05 [km.sup.2]). We applied quasi-Poisson mixed-effects models (with school random effect) to separately estimate associations between indicators of contact with green spaces and SDQ and ADHD total and subscale scores. RESULTS: We generally estimated beneficial associations between behavioral indicators and longer time spent in green spaces and beaches, and with residential surrounding greenness. Specifically, we found statistically significant inverse associations between green space playing time and SDQ total difficulties, emotional symptoms, and peer relationship problems; between residential surrounding greenness and SDQ total difficulties and hyperactivity/inattention and ADHD/DSM-IV total and inattention scores; and between annual beach attendance and SDQ total difficulties, peer relationship problems, and prosocial behavior. For proximity to major green spaces, the results were not conclusive. CONCLUSION: Our findings support beneficial impacts of contact with green and blue spaces on behavioral development in schoolchildren. Environ Health Perspect 122:1351-1358; http: //dx.doi.org/10.1289/ehp.1408215, Background Contact with green spaces has been reported to improve both perceived and objective physical and mental health and well-being (Bowler et al. 2010). Underlying mechanisms of health benefits of [...]
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- 2014
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79. Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
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Maitre, Léa, De Bont, Jeroen, Casas, Maribel, Robinson, Oliver, Aasvang, Gunn Marit, Agier, Lydiane, Andrušaitytė, Sandra, Ballester, Ferrán, Basagaña, Xavier, Borrás, Eva, Brochot, Céline, Bustamante, Mariona, Carracedo, Angel, De Castro, Montserrat, Dedele, Audrius, Donaire González, David, Estivill, Xavier, Evandt, Jorunn, Fossati, Serena, Giorgis Allemand, Lise, Granum, Berit, Grazuleviciene, Regina, Gützkow, Kristine Bjerve, Småstuen Haug, Line, Hernández Ferrer, Carles, Heude, Barbara, Ibarluzea Maurolagoitia, Jesús María, Julvez, Jordi, Karachaliou, Marianna, Keun, Hector C, Hjertager Krog, Norun, Lau, Chung-Ho E., Leventakou, Vasiliki, Lyon Caen, Sarah, Manzano, Cyntia, Mason, Dan, McEachan, Rosemary, Meltzer, Helle Margrete, Petraviciene, Inga, Quentin, Joane, Roumeliotaki, Theano, Sabido, Eduard, Saulnier, Pierre-Jean, Siskos, Alexandros P, Siroux, Valérie, Sunyer, Jordi, Tamayo, Ibon, Urquiza, Jose, Vafeiadi, Marina, Van Gent, Diana, Vives Usano, Marta, Waiblinger, Dagmar, Warembourg, Charline, Chatzi, Leda, Coen, Muireann, Van den Hazel, Peter, Nieuwenhuijsen, Mark J., Slama, Rémy, Thomsen, Cathrine, Wright, John, Vrijheid, Martine, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Norwegian Institute of Public Health [Oslo] (NIPH), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Vytautas Magnus University - Vytauto Didziojo Universitetas (VDU), Universitat de València (UV), Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne] (FISABIO), Centre for Genomic Regulation [Barcelona] (CRG), Universitat Pompeu Fabra [Barcelona] (UPF)-Centro Nacional de Analisis Genomico [Barcelona] (CNAG), Institut National de l'Environnement Industriel et des Risques (INERIS), Universidade de Santiago de Compostela [Spain] (USC ), CIBER de Enfermedades Raras (CIBERER), Sidra Medicine [Doha, Qatar], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), BIODonostia Research Institute, Public Health Division of Gipuzkoa, University of Crete [Heraklion] (UOC), Imperial College London, CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Harvard University [Cambridge], Keck School of Medicine [Los Angeles], University of Southern California (USC), Maastricht University [Maastricht], Veiligheids-en Gezondheidsregio Gelderland Midden [Arnhem, the Netherlands] (VGGM), Civs, Gestionnaire, Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Commission of the European Communities, Universidade de Santiago de Compostela. Departamento de Ciencias Forenses, Anatomía Patolóxica, Xinecoloxía e Obstetricia, e Pediatría, Universidade de Santiago de Compostela. Instituto de Ciencias Forenses 'Luis Concheiro'(INCIFOR), RS: NUTRIM - R3 - Respiratory & Age-related Health, and Complexe Genetica
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Male ,Urban Population ,Epidemiology ,Blood Pressure ,01 natural sciences ,0302 clinical medicine ,USE REGRESSION-MODELS ,Prospective Studies ,profile ,education.field_of_study ,Anthropometry ,public health ,birth cohort ,General Medicine ,3. Good health ,MOTHER ,Child, Preschool ,Prenatal Exposure Delayed Effects ,[SDV.TOX]Life Sciences [q-bio]/Toxicology ,Cohort ,Body Composition ,HEALTH ,Food Hypersensitivity ,Birth cohort ,medicine.medical_specialty ,Exposome ,exposome ,03 medical and health sciences ,land-use ,[SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health ,Humans ,education ,Psychological Tests ,child cohort ,Public health ,areas ,Infant ,Environmental Exposure ,AIR-POLLUTION ,DNA Methylation ,Omics ,medicine.disease ,CHILD COHORT ,exposure ,Attention Deficit Disorder with Hyperactivity ,Biomarkers ,Proteome ,Salut Pública ,Neurodevelopment ,use regression-models ,010501 environmental sciences ,AREAS ,11. Sustainability ,030212 general & internal medicine ,Prospective cohort study ,mother ,Smoking ,Community child health ,health ,omics ,Respiratory Function Tests ,[SDV.TOX] Life Sciences [q-bio]/Toxicology ,Europe ,PREGNANCY ,Exposoma ,Blood pressure ,Metabolome ,epidemiology ,Female ,pregnancy ,community child health ,Adult ,Population ,Mothers ,PROFILE ,Childhood obesity ,Hazardous Substances ,Young Adult ,Environmental health ,medicine ,air-pollution ,Body Weights and Measures ,EXPOSURE ,0105 earth and related environmental sciences ,[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health ,LAND-USE ,business.industry ,Respiratory health ,Infant, Newborn ,HELIX ,Socioeconomic Factors ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Gene-Environment Interaction ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,European population ,business ,Transcriptome - Abstract
Purpose Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and describe multiple environmental exposures during early life (pregnancy and childhood) in a prospective cohort and associate these exposures with molecular omics signatures and child health outcomes. Here, we describe recruitment, measurements available and baseline data of the HELIX study populations. Participants The HELIX study represents a collaborative project across six established and ongoing longitudinal population-based birth cohort studies in six European countries (France, Greece, Lithuania, Norway, Spain and the UK). HELIX used a multilevel study design with the entire study population totalling 31472 mother-child pairs, recruited during pregnancy, in the six existing cohorts (first level); a subcohort of 1301 mother-child pairs where biomarkers, omics signatures and child health outcomes were measured at age 6-11 years (second level) and repeat-sampling panel studies with around 150 children and 150 pregnant women aimed at collecting personal exposure data (third level). Findings to date Cohort data include urban environment, hazardous substances and lifestyle-related exposures for women during pregnancy and their offspring from birth until 6-11 years. Common, standardised protocols were used to collect biological samples, measure exposure biomarkers and omics signatures and assess child health across the six cohorts. Baseline data of the cohort show substantial variation in health outcomes and determinants between the six countries, for example, in family affluence levels, tobacco smoking, physical activity, dietary habits and prevalence of childhood obesity, asthma, allergies and attention deficit hyperactivity disorder. Future plans HELIX study results will inform on the early life exposome and its association with molecular omics signatures and child health outcomes. Cohort data are accessible for future research involving researchers external to the project. The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-206) under grant agreement no 308333-the HELIX project. Dr Maribel Casas and Dr Jordi Julvez received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128, MS14/00108). INMA data collections were supported by grants from the Instituto de Salud Carlos III, CIBERESP, the Conselleria de Sanitat, Generalitat Valenciana, Department of Health of the Basque Government; the Provincial Government of Gipuzkoa, and the Generalitat de Catalunya-CIRIT. KANC was funded by the grant of the Lithuanian Agency for Science Innovation and Technology (6-04-2014_31V-66). The Norwegian Mother and Child Cohort Study (MoBa) is supported by the Norwegian Ministry of Health and the Ministry of Education and Research, NIH/NIEHS (contract no. N01-ES-75558), and NIH/NINDS (grant no. 1 UO1 NS 047537-01 and grant no. 2 UO1 NS 047537-06A1). The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of Obesity and Neurodevelopmental Disorders in Preschool Children, in Heraklion district, Crete, Greece: 2011-2014; 'Rhea Plus': Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-2015). The work was also supported by MICINN (MTM2015-68140-R) and Centro Nacional de Genotipado-CEGEN-PRB2-ISCIII. CW received funding from the Fondation de France.
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- 2018
80. The Human Early-Life Exposome (HELIX): project rationale and design
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Vrijheid, Martine, Slama, Remy, Robinson, Oliver, Chatzi, Leda, Coen, Muireann, van den Hazel, Peter, Thomsen, Cathrine, Wright, John, Athersuch, Toby J., Avellana, Narcis, Basagana, Xavier, Brochot, Celine, Bucchini, Luca, Bustamante, Mariona, Carracedo, Angel, Casas, Maribel, Estivill, Xavier, Fairley, Lesley, van Gent, Diana, Gonzalez, Juan R., Granum, Berit, Grazuleviciene, Regina, Gutzkow, Kristine B., Julvez, Jordi, Keun, Hector C., Kogevinas, Manolis, McEachan, Rosemary R. C., Meltzer, Helle Margrete, Sabido, Eduard, Schwarze, Per E., Siroux, Valerie, Sunyer, Jordi, Want, Elizabeth J., Zeman, Florence, and Nieuwenhuijsen, Mark J.
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Genomes -- Research ,Children -- Health aspects ,Environmental quality -- Health aspects -- Research ,Biological markers -- Physiological aspects -- Research ,Environmental issues ,Health - Abstract
BACKGROUND: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure-health effect relationships. The 'exposome' concept encompasses the totality of exposures from conception onward, complementing the genome. OBJECTIVES: The Human Early-Life Exposome (HELIX) project is a new collaborative research project that aims to implement novel exposure assessment and biomarker methods to characterize early-life exposure to multiple environmental factors and associate these with omics biomarkers and child health outcomes, thus characterizing the 'early-life exposome.' Here we describe the general design of the project. METHODS: In six existing birth cohort studies in Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of chemical and physical exposures. Exposure models will be developed for the full cohorts totaling 32,000 mother-child pairs, and biomarkers will be measured in a subset of 1,200 mother--child pairs. Nested repeat-sampling panel studies (n = 150) will collect data on biomarker variability, use smartphones to assess mobility and physical activity, and perform personal exposure monitoring. Omics techniques will determine molecular profiles (metabolome, proteome, transcriptome, epigenome) associated with exposures. Statistical methods for multiple exposures will provide exposure-response estimates for fetal and child growth, obesity, neurodevelopment, and respiratory outcomes. A health impact assessment exercise will evaluate risks and benefits of combined exposures. CONCLUSIONS: HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood. As proof of concept, it will form an important first step toward the life-course exposome. http://dx.doi.org/10.1289/ehp.1307204, Introduction Environmental hazards such as ambient air pollution, environmental tobacco smoke (ETS), noise, pesticides, and radiation may lead to serious, chronic pathologies. The fetus and infant are particularly vulnerable to [...]
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- 2014
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81. Prenatal and Postnatal PCB-153 and p,p'-DDE Exposures and Behavior Scores at 5-9 Years of Age among Children in Greenland and Ukraine
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Rosenquist, Aske Hess, Hoyer, Birgit Bjerre, Julvez, Jordi, Sunyer, Jordi, Pedersen, Henning Sloth, Lenters, Virissa, Jonsson, Bo A.G., Bonde, Jens Peter, and Toft, Gunnar
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DDT -- Health aspects ,Polychlorinated biphenyls -- Health aspects ,Bioaccumulation -- Health aspects ,Childhood mental disorders -- Risk factors ,Environmental toxicology -- Research ,Child health -- Research ,Prenatal influences -- Health aspects ,Environmental issues ,Health - Abstract
Background: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior. Objective: We investigated the association between prenatal and early-life exposures to 2,2',4,4',5,5' -hexachlorobiphenyl (PCB-153) and 1,1dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) and behaviors in children between 5 and 9 y of age. Methods: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother-child pairs from Greenland and Ukraine (n = 1,018), maternal serum PCB-153 and p,p'-DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model. Parents completed the Strengths and Difficulties Questionnaire (SDQ), and children's behaviors were dichotomized as abnormal (high) versus normal/borderline for five SDQ subscales and the total difficulties score. Results: The total difficulties score, an overall measure of abnormal behavior, was not clearly associated with pre- or postnatal exposures to PCB-153 or to p,p'-DDE. However, pooled adjusted odds ratios (ORs) for high conduct problem scores with a doubling of exposure were 1.19 (95% CI: 0.99, 1.42) and 1.16 (95% CI: 0.96, 1.41) for pre- and postnatal PCB-153, respectively, and 1.25 (95% CI: 1.04, 1.51) and 1.24 (95% CI: 1.01, 1.51) for preand postnatal p,p'-DDE, respectively. Corresponding ORs for high hyperactivity scores were 1.24 (95% CI: 0.94, 1.62) and 1.08 (95% CI: 0.81, 1.45) for pre- and postnatal PCB-153, respectively, and 1.43 (95% CI: 1.06, 1.92) and 1.27 (95% CI: 0.93, 1.73) for pre- and postnatal-p,p'-DDE, respectively. Conclusion: Prenatal and early postnatal exposures to p,p'-DDE and PCB-153 were associated with a higher prevalence of abnormal scores for conduct and hyperactivity at 5-9 y of age in our study population. These findings provide further support for the importance of minimizing organochlorine exposures to young children and to women of childbearing age. https://doi.org/10.1289/EHP553, Introduction Polychlorinated biphenyls (PCBs) have been widely used in, for example, hydraulic equipment, dyes, plasticizers, capacitors, transformers and flame retardants. Dichlorodiphenyltrichloroethane (DDT) has been used primarily as a pesticide and [...]
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- 2017
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82. Maternal seafood consumption during pregnancy and child attention outcomes: a cohort study with gene effect modification by PUFA-related genes.
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Julvez, Jordi, Fernández-Barrés, Sílvia, Gignac, Florence, López-Vicente, Mónica, Bustamante, Mariona, Garcia-Esteban, Raquel, Vioque, Jesús, Llop, Sabrina, Ballester, Ferran, Fernández-Somoano, Ana, Tardón, Adonina, Vrijheid, Martine, Tonne, Cathryn, Ibarluzea, Jesus, Irazabal, Amaia, Sebastian-Galles, Nuria, Burgaleta, Miguel, Romaguera, Dora, and Sunyer, Jordi
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SEAFOOD , *ATTENTION-deficit hyperactivity disorder , *SINGLE nucleotide polymorphisms , *UNSATURATED fatty acids , *COHORT analysis , *RESEARCH , *RESEARCH methodology , *DIET , *MEDICAL cooperation , *EVALUATION research , *PRENATAL exposure delayed effects , *COMPARATIVE studies , *QUESTIONNAIRES , *LONGITUDINAL method - Abstract
Background: There is a need to test the fetal programming theoretical framework in nutritional epidemiology. We evaluated whether maternal seafood intake during pregnancy was associated with 8-year-old attention outcomes after adjusting for previous child seafood intake and cognitive function. We also explored effect modification by several single nucleotide polymorphisms (SNPs) related with polyunsaturated fatty acid (PUFA) metabolism.Methods: Our final analyses included 1644 mother-child pairs from the prospective INMA (INfancia y Medio Ambiente) cohort study (Spain, recruitment between 2003 and 2008). We used food frequency questionnaires to assess prenatal and postnatal seafood consumption of the mother-child pairs. We evaluated attention function of the children through the computer-based Attention Network Test (ANT) and we used the number of omission errors and the hit reaction time standard error (HRT-SE). Parents reported child attention deficit hyperactivity disorder (ADHD) symptoms using the Revised Conners' Parent Rating Scale Short Form (CPRS-R: S). We measured seven candidate SNPs in a subsample of 845 children. We estimated associations using regression models, adjusting for family characteristics, child seafood intake and cognitive functions at early ages, and to explore SNP effect modifications.Results: Higher total seafood intake during early pregnancy was associated with a reduction of child ANT omission errors, 5th quintile (median = 854 g/week) vs 1st quintile (median = 195 g/week), incidence risk ratio (IRR) 0.76; 95% CI = 0.61, 0.94. Similar results were observed after adjusting the models for child seafood intake and previous cognitive status. Lean, large and small fatty fish showed similar results, and generally similar but less robust associations were observed with the other attention outcomes. Shellfish and canned tuna showed weaker associations. The association patterns were weaker in late pregnancy and null in child seafood consumption. Child rs1260326 (glucokinase regulator, GCKR) and child/maternal rs2281591 (fatty acid elongase 2, ELOVL2) polymorphisms showed nominal P-value for interactions <0.10 between total seafood intake and ANT outcomes.Conclusions: After adjusting for previous child cognitive functions and child seafood intake, high pregnancy consumption (total, lean, small and large fatty fish) was independently associated with improvements of some 8-year-old attention outcomes. Genetic effect modification analyses suggest PUFA intake from seafood as a potential biological mechanism of such association. [ABSTRACT FROM AUTHOR]- Published
- 2020
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83. Head circumference and child ADHD symptoms and cognitive functioning: results from a large population-based cohort study.
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Ferrer, Muriel, García-Esteban, Raquel, Iñiguez, Carmen, Costa, Olga, Fernández-Somoano, Ana, Rodríguez-Delhi, Cristina, Ibarluzea, Jesús, Lertxundi, Aitana, Tonne, Cathryn, Sunyer, Jordi, and Julvez, Jordi
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ANTHROPOMETRY ,ATTENTION-deficit hyperactivity disorder ,BEHAVIORAL assessment ,CEPHALOMETRY ,CHILD development ,COGNITION ,CONFIDENCE intervals ,LONGITUDINAL method ,NEUROPSYCHOLOGICAL tests ,PSYCHOLOGICAL tests ,QUESTIONNAIRES ,SYMPTOMS ,CHILDREN - Abstract
The aim of this study is to understand the association between prenatal, newborn and postnatal head circumference (HC) and preschool neurodevelopment in a large population-based birth cohort. The INMA project followed 1795 children from 12 weeks of pregnancy to preschool years. HC measurements were carried out prospectively, and following a standardized protocol during pregnancy (12, 20 and 34 weeks), birth, and child ages of 1-1.5 and 4 years old; and z-scores were further estimated. Prenatal head growth was assessed using conditional z-scores between weeks 12-20 and 20-34. Several neuropsychological tests [MSCA (cognition), CPT (attention)] and behavioral rating scales [DSM-IV-ADHD, CAST (autism), CPSCS (social competence)] were carried out during the last follow-up (5 years old). Multivariable models adjusted for family and child characteristics were applied to analyze associations between HC and neurodevelopment. In fully adjusted models, prenatal HC and head growth showed little or no associations with the neurodevelopment outcomes. Independent associations were observed between HC z-scores at birth, 1-1.5 years and 4 years and MSCA global cognitive scores and DSM-IV inattention symptoms. Specifically, z-score at birth was positively associated with general cognitive scores [β 1.22, 95% confidence interval (CI) 0.59, 1.85], and we observed a protective association with ADHD-DSM-IV total symptoms, mean ratio (MR) 0.85 (0.75, 0.96). Prenatal HC and head growth measurements gave little information about child cognitive abilities and behavior at preschool years. However, HC at birth and early childhood was positively associated with a range of neuropsychological outcomes, including protective associations with ADHD symptoms. [ABSTRACT FROM AUTHOR]
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- 2019
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84. Feeding Children Walnuts.
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Julvez, Jordi
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WALNUT ,COGNITION ,ADOLESCENT health ,NATURAL foods - Abstract
The article focuses on the benefits of consuming walnuts for Teenagers cognitive development and psychological maturation and it reports that walnuts, which are rich in alpha-linolenic fatty acid (ALA), a type of omega-3, play a crucial role in brain development during this stage of life.
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- 2023
85. Iodine Supplementation During Pregnancy and Infant Neuropsychological: INMA Mother and Child Cohort Study
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Rebagliato, Marisa, Murcia, Mario, Álvarez Pedrerol, Mar, Espada, Mercedes, Fernández Somoano, Ana, Lertxundi, Nerea, Navarrete-Muñoz, Eva María, Forns, Joan, Aranbarri, Aritz, Llop, Sabrina, Julvez, Jordi, Tardon, Adonina, and Ballester, Ferran
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Prenatal nutritional physiological phenomena ,Diietary supplements ,Fetal development ,Child development ,Iodine - Abstract
Iodine supplementation during pregnancy is a common practice in developed countries. However, scant evidence is available regarding the safety and effectiveness of maternal iodine supplementation with regard to child neuropsychological development. We previously reported an inverse association between iodine supplementation and the psychomotor development of infants in a birth cohort from Valencia, Spain. In the present study, we assessed this association in a wider sample of mother and child pairs from 3 other regions in Spain. Neuropsychological development was assessed using the Bayley Scales of Infant Development in 1,519 infants (median age, 16 months) between 2006 and 2009. In multivariate analyses, maternal consumption of 150 μg/day or more of iodine from supplements was related to a 1.5-fold increase in the odds of a psychomotor score less than 85 (95% confidence interval: 0.8, 2.9) and to a 1.7-fold increase in the odds of a mental score less than 85 (95% confidence interval: 0.9, 3.0). Findings previously reported in the Valencia cohort were only partially verified. The results of the present study suggest that, at least in these regions, iodine supplementation does not improve infant neuropsychological development at 1 year of age. Further research is needed on the risks and benefits of supplementary iodine for both maternal thyroid function and child neurodevelopment.
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- 2013
86. Effect of maternal high dosages of folic acid supplements on neurocognitive development in children at 4-5 y of age: the prospective birth cohort Infancia y Medio Ambiente (INMA) study.
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Valera-Gran, Desirée, Navarrete-Muñoz, Eva M., Garcia de la Hera, Manuela, Fernández-Somoano, Ana, Tardón, Adonina, Ibarluzea, Jesús, Balluerka, Nekane, Murcia, Mario, González-Safont, Llúcia, Romaguera, Dora, Julvez, Jordi, and Vioque, Jesús
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FOLIC acid in human nutrition ,PEDIATRIC neuropsychology ,MOTHER-child relationship ,NEURAL development ,COGNITIVE development research ,DEVELOPMENTAL neurobiology ,COHORT analysis ,COGNITION in children ,CHILD development ,DATE of conception ,CONFIDENCE intervals ,FOLIC acid ,INTERVIEWING ,LANGUAGE acquisition ,LONGITUDINAL method ,NEUROPSYCHOLOGICAL tests ,MEDICAL cooperation ,MEMORY in children ,META-analysis ,MOTHERS ,NEUROPSYCHOLOGY ,NUTRITIONAL assessment ,NUTRITION policy ,NUTRITIONAL requirements ,QUESTIONNAIRES ,RESEARCH ,RESEARCH evaluation ,EVIDENCE-based medicine ,PROFESSIONAL practice ,MULTIPLE regression analysis ,PREGNANCY - Abstract
Background: The benefits of the use of folic acid supplements (FASs) during the periconception period to prevent neural tube defects and to ensure normal brain development in offspring are well known. There is concern, however, about the long-term effects of the maternal use of high dosages of FASs that exceed the Tolerable Upper Intake Level (UL) (≥1000 µg/d) on child neurocognitive outcomes. Objective: The objective of the study was to examine the association between the use of high dosages of FASs during pregnancy and child neuropsychological development at ages 4-5 y. Design: The multicenter prospective mother-child cohort study, the Infancia y Medio Ambiente (INMA) Project, was conducted in 4 regions of Spain: Asturias, Sabadell, Gipuzkoa, and Valencia. Pregnant women were recruited between 2003 and 2008. Data on 1682 mother-child pairs were included in the final analyses. The pregnant women completed an interviewer-administered questionnaire that was validated to estimate typical dietary folate intake and the use of FASs at 10-13 and 28-32 wk of gestation. Neuropsychological development scores at 4-5 y of age were estimated with the use of the McCarthy Scales of Children's Abilities. Multiple linear regression and meta-analysis were used to obtain combined-effect estimates. Results: During the periconception period, one-third of the women (n = 502) took FAS dosages ≥1000 μg/d. The use of FAS dosages ≥1000 µg/d in this period was negatively associated with several neuropsychological outcomes scores in children: global verbal (β = -2.49; 95% CI: -4.71, -0.27), verbal memory (β = -3.59; 95% CI: -6.95, -0.23), cognitive function of posterior cortex (β = -2.31; 95% CI: -4.45, -0.18), and cognitive function of left posterior cortex (β = -3.26; 95% CI: -5.51, -1.01). Conclusions: The use of FAS dosages exceeding the UL (≥1000 µg/d) during the periconception period was associated with lower levels of cognitive development in children aged 4-5 y. The use of FAS dosages ≥1000 µg/d during pregnancy should be monitored and prevented as much as possible, unless medically prescribed. [ABSTRACT FROM AUTHOR]
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- 2017
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87. Inteligencia y salud mental maternas y desarrollo neuropsicológico infantil a los 14 meses de edad
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Forns, Joan, Julvez, Jordi, García-Esteban, Raquel, Guxens, Mònica, Ferrer, Muriel, Grellier, James, Vrijheid, Martine, and Sunyer, Jordi
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Desarrollo infantil ,Salud mental ,Neuropsychology ,Intelligence ,Mental health ,Child development ,Neuropsicología ,Inteligencia - Abstract
Objective: To examine the relationship between maternal intelligence-mental health and neuropsychological development at age 14 months in a normal population, taking into account maternal occupational social class and education. Methods: We prospectively studied a population-based birth cohort, which forms part of the INMA (Environment and Childhood) Project. Cognitive and psychomotor development was assessed at 14 months using Bayley Scales of Infant Development. Maternal intelligence and mental health were assessed by the Cattell and Cattell test and the General Health Questionnaire-12 respectively. Results: We observed a crude association between maternal intelligence and cognitive development in children at 14 months but this association disappeared when maternal education was included. The associations were stratified by maternal education and occupational social class. Within the manual maternal occupational social class, there was a significant difference in cognitive development between children whose mothers scored in the highest tertile of maternal IQ and those whose mothers scored in the lowest tertile. In contrast, no differences were observed among children whose mothers were in the non-manual occupational social class. Conclusions: The association between maternal intelligence and child cognitive development differed by occupational social class. While this association was not confounded by education or other variables in manual occupational social classes, maternal education explained this association among advantaged occupational social classes. Objetivos: Este estudio exploró la relación entre inteligencia y salud mental materna y desarrollo neuropsicológico infantil a los 14 meses de edad en población normal, teniendo en cuenta la clase social basada en la ocupación y el nivel educativo maternos. Métodos: Estudio prospectivo de cohortes de nacimiento englobado dentro del proyecto INMA (Infancia y Medio Ambiente). El desarrollo cognitivo y psicomotor fue evaluado mediante la escala Bayley de desarrollo infantil. La inteligencia y la salud mental maternas se evaluaron usando el Test de Cattell y Cattell, y el Cuestionario de Salud General de 12 ítems, respectivamente. Resultados: Se observó una asociación cruda entre inteligencia materna y desarrollo cognitivo infantil a los 14 meses de edad. Sin embargo, esta asociación desaparecía cuando la educación materna era incluida. Las asociaciones fueron estratificadas por educación y clase social basada en la ocupación materna. En el estrato de clase social manual materna se observó una diferencia significativa en la escala mental de la escala Bayley entre esos niños cuyas madres puntuaron en el tercil más alto de inteligencia materna, comparado con el tercil más bajo. No obstante, no se observaron diferencias entre aquellos niños de clase social no manual materna. Conclusiones: Existe un patrón diferente en la asociación entre inteligencia materna y desarrollo cognitivo infantil según la clase social materna. Mientras la asociación no es confundida por la educación ni por otras variables en las clases sociales manuales, el nivel educativo materno explica esta asociación en las clases sociales no manuales.
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- 2012
88. Prenatal exposure to mercury and neuropsychological development in young children: the role of fish consumption.
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Llop, Sabrina, Ballester, Ferran, Murcia, Mario, Forns, Joan, Tardon, Adonina, Andiarena, Ainara, Vioque, Jesús, Ibarluzea, Jesús, Fernández-Somoano, Ana, Sunyer, Jordi, Julvez, Jordi, Rebagliato, Marisa, and Lopez-Espinosa, Maria-Jose
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PRENATAL exposure delayed effects ,PREGNANCY complications ,PRENATAL influences ,NEUROPSYCHOLOGICAL tests ,CLINICAL neuropsychology ,CHILD development ,COMPARATIVE studies ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,MERCURY ,MULTIVARIATE analysis ,REGRESSION analysis ,RESEARCH ,SEAFOOD ,UNSATURATED fatty acids ,EVALUATION research ,MATERNAL exposure - Abstract
Background: Vulnerability of the central nervous system to mercury exposure is increased during early development. The aim of this study is to evaluate the association between prenatal exposure to mercury and child neuropsychological development in high-fish-intake areas in Spain.Methods: Study subjects were 1362 children, participants in the INMA (Environment and Childhood) birth cohort study. Cord blood total mercury (CB-Hg) and cord polyunsaturated fatty acids (PUFA) concentrations were analysed in samples collected between 2004 and 2008. Child neuropsychological development was assessed at age 4-5 years by the McCarthy Scales of Children's Abilities (MSCA). Socio-demographic, lifestyle and dietary information was obtained by questionnaires administered during pregnancy and childhood.Results: The geometric mean of CB-Hg was 8.8 µg/L [95% confidence interval (CI) 8.4, 9.2]. A doubling in CB-Hg was associated with higher scores in most of the MSCA scales ( β =1.29; 95% CI 0.28, 2.31 for the general cognitive scale). The association between CB-Hg and the scores obtained on the scales was inverse among children whose mothers consumed fewer than three weekly servings of fish during the first trimester of pregnancy, although confidence intervals did not exclude the null ( β =-1.20; 95% CI -2.62, 0.22 for the perceptive-manipulative scale and β =-3.06; 95% CI -6.37, 0.24 for the general cognitive scale). An inverse association between CB-Hg and the scores on the motor scale was also suggested for children with an n-6/n-3 PUFA ratio above the median ( β =-0.23; 95% CI -0.87, 0.40, interaction p -value=0.03).Conclusion: The relationship between CB-Hg concentrations and child neuropsychological development was influenced by maternal nutritional factors, such as fish consumption and the PUFA status. [ABSTRACT FROM AUTHOR]- Published
- 2017
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89. A Longitudinal Study on Attention Development in Primary School Children with and without Teacher-Reported Symptoms of ADHD.
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Suades-González, Elisabet, Forns, Joan, García-Esteban, Raquel, López-Vicente, Mónica, Esnaola, Mikel, Álvarez-Pedrerol, Mar, Julvez, Jordi, Cáceres, Alejandro, Basagaña, Xavier, López-Sala, Anna, and Sunyer, Jordi
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Background: Prospective longitudinal studies are essential in characterizing cognitive trajectories, yet few of them have been reported on the development of attention processes in children. We aimed to explore attention development in normal children and children with attention deficit and hyperactivity disorder (ADHD) symptoms in a repeated measures design using the attention network test (ANT). Methods: The population sample included 2,835 children (49.6% girls) aged 7-11 years from 39 schools in Barcelona (Catalonia, Spain) who performed the ANT four times from January 2012 to March 2013. According to teacher ratings, 10.5% of the children presented ADHD symptoms. We performed multilevel mixed-effects linear regression models, adjusting for school and individual, to test the effects of age-related growth on the ANT networks: alerting, orienting and executive attention, and three measurements related to attentiveness: median of hit reaction time (HRT), hit reaction time standard error (HRT-SE) and variability. Results: We observed age-related growth in all the outcomes, except orienting. The curves were steeper at the younger groups, although for alertness the improvement was further at the oldest ages. Gender and ADHD symptoms interacted with age in executive attention, HRT and variability. Girls performed better in executive attention at young ages although boys reached females at around 10 years of age. For HRT, males showed faster HRT. However, girls had a more pronounced improvement and reached the levels of boys at age 11. Children with ADHD symptoms had significant differences in executive attention, HRT and variability compared to children without ADHD symptoms. Conclusions: We detected an ongoing development of some aspects of attention in primary school children, differentiating patterns by gender and ADHD symptoms. Our findings support the ANT for assessing attention processes in children in large epidemiological studies. [ABSTRACT FROM AUTHOR]
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- 2017
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90. Acetaminophen use in pregnancy and neurodevelopment: attention function and autism spectrum symptoms.
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Avella-Garcia, Claudia B., Julvez, Jordi, Fortuny, Joan, Rebordosa, Cristina, García-Esteban, Raquel, Galán, Isolina Riaño, Tardón, Adonina, Clara L Rodríguez-Bernal, Clara L., Iñiguez, Carmen, Andiarena, Ainara, Santa-Marina, Loreto, Sunyer, Jordi, and Rodríguez-Bernal, Clara L
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ACETAMINOPHEN , *AUTISM spectrum disorders in children , *CHILDREN with attention-deficit hyperactivity disorder , *NEURODEVELOPMENTAL treatment , *HYPERACTIVITY , *DRUG side effects , *ATTENTION , *BEHAVIOR , *CHILD development , *LONGITUDINAL method , *NEUROPSYCHOLOGICAL tests , *CLASSIFICATION of mental disorders , *MULTIVARIATE analysis , *PSYCHOLOGICAL tests , *REGRESSION analysis , *SEX distribution , *NONOPIOID analgesics , *PRENATAL exposure delayed effects - Abstract
Background: Acetaminophen is extensively used during pregnancy. But there is a lack of population-representative cohort studies evaluating its effects on a range of neuropsychological and behavioural endpoints. We aimed to assess whether prenatal exposure to acetaminophen is adversely associated with neurodevelopmental outcomes at 1 and 5 years of age.Methods: This Spanish birth cohort study included 2644 mother-child pairs recruited during pregnancy. The proportion of liveborn participants evaluated at 1 and 5 years was 88.8% and 79.9%, respectively. Use of acetaminophen was evaluated prospectively in two structured interviews. Ever/never use and frequency of use (never, sporadic, persistent) were measured. Main neurodevelopment outcomes were assessed using Childhood Autism Spectrum Test (CAST), Conner's Kiddie Continuous Performance Test (K-CPT) and ADHD-DSM-IV form list. Regression models were adjusted for social determinants and co-morbidities.Results: Over 40% of mothers reported using acetaminophen. Ever-exposed offspring had higher risks of presenting more hyperactivity/impulsivity symptoms [incidence rate ratio (IRR) = 1.41, 95% confidence interval (CI) 1.01-1.98), K-CPT commission errors (IRR = 1.10, 1.03-1.17), and lower detectability scores (coefficient β = -0.75, -0.13--0.02). CAST scores were increased in ever-exposed males (β = 0.63, 0.09-1.18). Increased effect sizes of risks by frequency of use were observed for hyperactivity/impulsivity symptoms (IRR = 2.01, 0.95-4.24) in all children, K-CPT commission errors (IRR = 1.32, 1.05-1.66) and detectability (β = -0.18, -0.36-0.00) in females, and CAST scores in males (β = 1.91, 0.44-3.38).Conclusions: Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males and showed adverse effects on attention-related outcomes for both genders. These associations seem to be dependent on the frequency of exposure. [ABSTRACT FROM AUTHOR]- Published
- 2016
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91. Dietary Intake of Trans Fatty Acids in Children Aged 4--5 in Spain: The INMA Cohort Study.
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Scholz, Alexander, Gimenez-Monzo, Daniel, Navarrete-Muñoz, Eva Maria, Garcia-de-la-Hera, Manuela, Fernandez-Somoano, Ana, Tardon, Adonina, Santa Marina, Loreto, Irazabal, Amaia, Romaguera, Dora, Guxens, Mònica, Julvez, Jordi, Llop, Sabrina, Lopez-Espinosa, Maria-Jose, and Vioque, Jesus
- Abstract
Trans fatty acid (TFA) intake has been identified as a health hazard in adults, but data on preschool children are scarce. We analyzed the data from the Spanish INMA Project to determine the intake of total, industrial and natural TFA, their main sources and the associated socio-demographic and lifestyle factors in children aged 4-5 (n = 1793). TFA intake was estimated using a validated Food Frequency Questionnaire, and multiple linear regression was used to explore associated factors. The mean daily intakes of total, industrial and natural TFA were 1.36, 0.60, and 0.71 g/day, respectively. Ten percent of the children obtained >1% of their energy intake from TFA. The main sources of industrial TFA were fast food, white bread and processed baked goods. Milk, red and processed meat and processed baked goods were the main sources of natural TFA. Having parents from countries other than Spain was significantly associated with higher natural TFA (in mg/day) intake (α 45.5) and television viewing was significantly associated with higher industrial TFA intake (α 18.3). Higher fruits and vegetables intake was significantly associated with lower intakes of all TFAs, whereas higher sweetened beverages intake was significantly associated with lower total and natural TFA intake. Thus, total and industrial TFA intake was associated with less healthy food patterns and lifestyles in Spanish preschool children. [ABSTRACT FROM AUTHOR]
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- 2016
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92. Folic Acid Supplements During Pregnancy and Child Psychomotor Development After the First Year of Life.
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Valera-Gran, Desirée, García de la Hera, Manuela, Navarrete-Muñoz, Eva María, Fernandez-Somoano, Ana, Tardón, Adonina, Julvez, Jordi, Forns, Joan, Lertxundi, Nerea, Ibarluzea, Jesús María, Murcia, Mario, Rebagliato, Marisa, and Vioque, Jesús
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- 2014
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93. Epidemiological Evidence on Methylmercury Neurotoxicity.
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Julvez, Jordi, Yorifuji, Takashi, Choi, Anna L., and Grandjean, Philippe
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- 2012
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94. Lutein and Zeaxanthin Intake during Pregnancy and Visual Function in Offspring at 11–12 Years of Age.
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Anderson, Martin J., Romaguera, Dora, Saint-Amour, Dave, Fossati, Serena, Fochs, Silvia, Pey, Nuria, Vrijheid, Martine, and Julvez, Jordi
- Abstract
(1) Background: Lutein and zeaxanthin (L&Z) are essential dietary nutrients that are a crucial component of the human macula, contributing to visual functioning. They easily cross the placental barrier, so that retinal deposition commences during foetal development. This study aims to assess associations between maternal L&Z intake during pregnancy and offspring visual function at 11–12 years. (2) Methods: Using the Spanish INfancia y Medio Ambiente project (INMA) Sabadell birth cohort, 431 mother–child pairs were analysed. L&Z data were obtained from food frequency questionnaires (FFQ) at week 12 and 32 of pregnancy, alongside other nutritional and sociodemographic covariates. Contrast vision (CS) and visual acuity (VA) were assessed using the automated Freiburg Acuity and Contrast Testing (FRACT) battery. Low CS and VA were defined as being below the 20th cohort centile. Associations were explored using multiple logistic regression. (3) Results: After controlling for potential confounders, L&Z intake during the 1st and 3rd trimester did not reveal any statistically significant association with either CS or VA in offspring at age 11/12 years. (4) Conclusions: No evidence of a long-term association between L&Z intake during pregnancy and visual function in offspring was found. Further larger long-term studies including blood L&Z levels are required to confirm this result. [ABSTRACT FROM AUTHOR]
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- 2022
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95. Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain.
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Tahaei, Hana, Gignac, Florence, Pinar, Ariadna, Fernandez-Barrés, Silvia, Romaguera, Dora, Vioque, Jesus, Santa-Marina, Loreto, Subiza-Pérez, Mikel, Llop, Sabrina, Soler-Blasco, Raquel, Arija, Victoria, Salas-Salvadó, Jordi, Tardón, Adonina, Riaño-Galán, Isolina, Sunyer, Jordi, Guxens, Monica, and Julvez, Jordi
- Abstract
Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the child. This study aims to explore the association between maternal n-3 PUFA intake during two periods of pregnancy and the child's neuropsychological scores at different ages. Methods: Prospective data were obtained for 2644 pregnant women recruited between 2004 and 2008 in population-based birth cohorts in Spain. Maternal n-3 PUFA intake during the first and third trimester of pregnancy was estimated using validated food frequency questionnaires. Child neuropsychological functions were assessed using Bayley Scales of Infant Development version one (BSID) at 1 year old, the McCarthy Scale of Children's Abilities (MSCA) at 4 years old, and the Attention Network Test (ANT) at 7 years old. Data were analysed using multivariate linear regression models and adjusted for potential covariates, such as maternal social class, education, cohort location, alcohol consumption, smoking, breastfeeding duration, and energy intake. Results: Compared to participants in the lowest quartile (<1.262 g/day) of n-3 PUFA consumption during the first trimester, those in the highest quartile (>1.657 g/day) had a 2.26 points (95% confidence interval (CI): 0.41, 4.11) higher MSCA general cognitive score, a 2.48 points (95% CI: 0.53, 4.43) higher MSCA verbal score, and a 2.06 points (95% CI: 0.166, 3.95) higher MSCA executive function score, and a 11.52 milliseconds (95% CI: −22.95, −0.09) lower ANT hit reaction time standard error. In the third pregnancy trimester, the associations were weaker. Conclusions: Positive associations between n-3 PUFA intake during early pregnancy and child neuropsychological functions at 4 and 7 years of age were found, and further clinical research is needed to confirm these findings. [ABSTRACT FROM AUTHOR]
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- 2022
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96. Hours of television viewing and sleep duration in children: a multicenter birth cohort study.
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Marinelli, Marcella, Sunyer, Jordi, Alvarez-Pedrerol, Mar, Iñiguez, Carmen, Torrent, Maties, Vioque, Jesús, Turner, Michelle C, and Julvez, Jordi
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- 2014
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97. Positive health effects of the natural outdoor environment in typical populations in different regions in Europe (PHENOTYPE): a study programme protocol.
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Nieuwenhuijsen, Mark J., Kruize, Hanneke, Gidlow, Christopher, Andrusaityte, Sandra, Antó, Josep Maria, Basagaña, Xavier, Cirach, Marta, Dadvand, Payam, Danileviciute, Asta, Donaire-Gonzalez, David, Garcia, Judith, Jerrett, Michael, Jones, Marc, Julvez, Jordi, van Kempen, Elise, van Kamp, Irene, Maas, Jolanda, Seto, Edmund, Smith, Graham, and Triguero, Margarita
- Abstract
Introduction: Growing evidence suggests that close contact with nature brings benefits to human health and well-being, but the proposed mechanisms are still not well understood and the associations with health remain uncertain. The Positive Health Effects of the Natural Outdoor environment in Typical Populations in different regions in Europe (PHENOTYPE) project investigates the interconnections between natural outdoor environments and better human health and well-being. Aims and methods: The PHENOTYPE project explores the proposed underlying mechanisms at work (stress reduction/restorative function, physical activity, social interaction, exposure to environmental hazards) and examines the associations with health outcomes for different population groups. It implements conventional and new innovative high-tech methods to characterise the natural environment in terms of quality and quantity. Preventive as well as therapeutic effects of contact with the natural environment are being covered. PHENOTYPE further addresses implications for land-use planning and green space management. The main innovative part of the study is the evaluation of possible short-term and long-term associations of green space and health and the possible underlying mechanisms in four different countries (each with quite a different type of green space and a different use), using the same methodology, in one research programme. This type of holistic approach has not been undertaken before. Furthermore there are technological innovations such as the use of remote sensing and smartphones in the assessment of green space. Conclusions: The project will produce a more robust evidence base on links between exposure to natural outdoor environment and human health and well-being, in addition to a better integration of human health needs into land-use planning and green space management in rural as well as urban areas. [ABSTRACT FROM AUTHOR]
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- 2014
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98. Genetic Variants of the FADS Gene Cluster and ELOVL Gene Family, Colostrums LC-PUFA Levels, Breastfeeding, and Child Cognition.
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Morales, Eva, Bustamante, Mariona, Gonzalez, Juan Ramon, Guxens, Monica, Torrent, Maties, Mendez, Michelle, Garcia-Esteban, Raquel, Julvez, Jordi, Forns, Joan, Vrijheid, Martine, Molto-Puigmarti, Carolina, Lopez-Sabater, Carmen, Estivill, Xavier, and Jordi Sunyer
- Subjects
MAMMARY gland secretions ,COGNITION in children ,BREASTFEEDING ,BREAST milk ,PREGNANT women ,INFANT development ,BAYLEY Scales of Infant Development - Abstract
Introduction: Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in fatty acid desaturase (FADS) and elongase (ELOVL) enzymes has been overlooked when studying the effects of LC-PUFAs supply on cognition. We aimed to: 1) to determine whether maternal genetic variants in the FADS cluster and ELOVL genes contribute to differences in LC-PUFA levels in colostrum; 2) to analyze whether these maternal variants are related to child cognition; and 3) to assess whether children's variants modify breastfeeding effects on cognition. Methods: Data come from two population-based birth cohorts (n = 400 mother-child pairs from INMA-Sabadell; and n = 340 children from INMA-Menorca). LC-PUFAs were measured in 270 colostrum samples from INMA-Sabadell. Tag SNPs were genotyped both in mothers and children (13 in the FADS cluster, 6 in ELOVL2, and 7 in ELOVL5). Child cognition was assessed at 14 mo and 4 y using the Bayley Scales of Infant Development and the McCarthy Scales of Children's Abilities, respectively. Results: Children of mothers carrying genetic variants associated with lower FADS1 activity (regulating AA and EPA synthesis), higher FADS2 activity (regulating DHA synthesis), and with higher EPA/AA and DHA/AA ratios in colostrum showed a significant advantage in cognition at 14 mo (3.5 to 5.3 points). Not being breastfed conferred an 8- to 9-point disadvantage in cognition among children GG homozygote for rs174468 (low FADS1 activity) but not among those with the A allele. Moreover, not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele. Conclusion: Genetically determined maternal supplies of LC-PUFAs during pregnancy and lactation appear to be crucial for child cognition. Breastfeeding effects on cognition are modified by child genetic variation in fatty acid desaturase and elongase enzymes. [ABSTRACT FROM AUTHOR]
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- 2011
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99. Sensitivity of continuous performance test (CPT) at age 14years to developmental methylmercury exposure
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Julvez, Jordi, Debes, Frodi, Weihe, Pal, Choi, Anna, and Grandjean, Philippe
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CONTINUOUS performance test , *METHYLMERCURY , *NEUROPSYCHOLOGY , *COGNITION , *BIOMARKERS , *NEUROTOXICOLOGY , *FRONTAL lobe , *REACTION time - Abstract
Abstract: Hit Reaction Time latencies (HRT) in the Continuous Performance Test (CPT) measure the speed of visual information processing. The latencies may involve different neuropsychological functions depending on the time from test initiation, i.e., first orientation, learning and habituation, then cognitive processing and focused attention, and finally sustained attention as the dominant demand. Prenatal methylmercury exposure is associated with increased reaction time (RT) latencies. We therefore examined the association of methylmercury exposure with the average HRT at age 14years at three different time intervals after test initiation. A total of 878 adolescents (87% of birth cohort members) completed the CPT. The RT latencies were recorded for 10min, with visual targets presented at 1000ms intervals. After confounder adjustment, regression coefficients showed that CPT-RT outcomes differed in their associations with exposure biomarkers of prenatal methylmercury exposure: During the first 2min, the average HRT was weakly associated with methylmercury (beta (SE) for a ten-fold increase in exposure, (3.41 (2.06)), was strongly for the 3-to-6min interval (6.10 (2.18)), and the strongest during 7–10min after test initiation (7.64 (2.39)). This pattern was unchanged when simple reaction time and finger tapping speed were included in the models as covariates. Postnatal methylmercury exposures did not affect the outcomes. Thus, these findings suggest that sustained attention as a neuropsychological domain is particularly vulnerable to developmental methylmercury exposure, indicating probable underlying dysfunction of the frontal lobes. When using CPT data as a possible measure of neurotoxicity, test results should therefore be analyzed in regard to time from test initiation and not as overall average reaction times. [Copyright &y& Elsevier]
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- 2010
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100. Prenatal Exposure to Cell Phone Use and Neurodevelopment at 14 Months.
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Vrijheid, Martine, Martinez, David, Forns, Joan, Guxens, Mònica, Julvez, Jordi, Ferrer, Muriel, and Sunyer, Jordi
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- 2010
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