47 results on '"Arsić, Biljana"'
Search Results
2. Synthesis of methyl 3,4-anhydro-6-bromo-2-O-tert-butyldimethylsilyl-6-deoxy-α-d-allopyranoside from α-d-glucose
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Glišin Đorđe, Jovanović Olga, Stojanović Gordana, Živković Aleksandra, Stojanović Dragan, Pavlović Marina, and Arsić Biljana
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d-allose derivative ,3,4-epoxide ring ,selective silylation ,carbohydrates ,Chemistry ,QD1-999 - Abstract
Some of simple carbohydrates and their derivatives are used for the clinical treatment of various diseases. Epoxide derivatives, which can be obtained by the intramolecular elimination of water from two vicinal hydroxyl groups, are stable, but sufficiently reactive compounds very often used as intermediaries in various syntheses. Synthesis of epoxide derivative, methyl 3,4-anhydro- -6-bromo-2-O-tert-butyldimethylsilyl-6-deoxy-α-D-allopyranoside from α-D-glucose was achieved in high yields in the minimal number of synthetic steps. Anhydrous glucose was used as a starting material which was transformed into methyl α-D-glucopyranoside using dry, gaseous hydrogen chloride. Thus obtained derivative was treated with benzaldehyde in the presence of zinc chloride as Lewis acid giving methyl (R)-4,6-O-benzylidene-α-D-glucopyranoside. The obtained compound was treated with N-bromosuccinimide (NBS) in dichloromethane in the presence of barium carbonate giving methyl 4-O-benzoyl-6- -bromo-6-deoxy-α-D-glucopyranoside. In the next step, the obtained compound was treated with tert-butyldimethylsilyl chloride (TBDMSCl) in pyridine, and methyl 4-O-benzoyl-6-bromo-2-O-tert-butyldimethylsilyl-6-deoxy-α-D-glucopyranoside was further mesylated, and the obtained methyl 4-O-benzoyl-6- -bromo-2-O-tert-butyldimethylsilyl-6-deoxy-3-O-mesyl-α-D-glucopyranoside was treated at the end with KOH to give methyl 3,4-anhydro-6-bromo-2-O-tert- -butyldimethylsilyl-6-deoxy-α-D-allopyranoside (yield 78 %).
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- 2024
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3. Stability and computational analyses of selected pesticides in use in the Republic of Serbia
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Arsić Biljana, Petrović Stefan, Mrmošanin Jelena, Dimitrijević Ivana, Tošić Snežana, Stojanović Gordana, Glišić Sanja, and Milićević Jelena
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gc-ms ,alzheimer’s disease ,admet ,Chemistry ,QD1-999 - Abstract
Pesticides commonly used in the Republic of Serbia (tebuconazole, pendimethalin, pyraclostrobin, propiconazole and famoxadone) have high stability, so their potential toxicity to humans needs to be investigated. These pesticides are in use in the Republic of Serbia in various formulations. Their toxicity and interactions with acetylcholinesterase were thoroughly investigated in this study using computational tools. The ADMET (adsorption, distribution, metabolism, excretion, toxicity) study showed that all of them are efficient oral compounds, and that pendimethalin was a mutagenic compound. Glide scores ranged from –18.41 (pendimethalin) to –27.61 kJ mol-1 (famoxadone) in Mus musculus, and from –19.58 (pendimethalin) to –24.31 kJ mol-1 (propiconazole) in Homo sapiens. In addition, the experimental stability of the pesticides solutions in methanol was studied using the fast gas chromatography–mass spectrometry (GC–MS, retention times of the studied pesticides ranged from 14.47 (pendimethalin) to 22 min (famoxadone)). They showed good stability over time, apart from pyraclostrobin which decomposed mainly into its desmethoxy derivative after 20 months. Based on the promising modelling results, pyraclostrobin and famoxadone emerge as potential candidates for further investigation in the treatment of Alzheimer’s disease, taking care to increase their stability.
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- 2024
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4. Pregnancy outcomes and newborn characteristics in women with follicular fluid thyroid autoantibodies undergoing assisted reproduction
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Medenica Sanja, Garalejić Eliana, Abazović Džihan, Bukumirić Zoran, Paschou Stavroula A., Arsić Biljana, Vujošević Snežana, Međo Biljana, and Žarković Miloš
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assisted reproductive technology ,follicular fluid ,pregnancy ,thyroid autoimmunity ,Biochemistry ,QD415-436 - Abstract
Background: Higher levels of thyroid autoantibodies in follicular fluid (FF) of thyroid autoimmunity (TAI) positive women are strongly correlated with serum levels and may have effect on the post-implantation embryo development. Literature highlights that levothyroxine (LT4) treatment may attenuate the risk of adverse pregnancy outcomes. The aim of the study was to estimate the pregnancy and newborn outcomes in women with FF thyroid autoantibodies undergoing assisted reproductive technology (A RT). Methods: The study population included 24 women with confirmed clinical pregnancy, 8 TAI positive and 16 TAI negative women. LT4 supplementation was applied in 20.8% patients, TAI positive. Results: Pregnancy outcomes were: twin pregnancy rate 4 1 .7 % , early miscarriage rate 8.3% , late miscarriage rate 4.2% , preterm birth rate 16.7% , term birth rate 70.8% , live birth rate 96.0% . There was significant difference in serum and in FF TgAbs (p< 0.001)betw een the groups according to TAI, while serum fT 3 was lower in the group with TAI (p = 0 .0 4 7 ). Serum P 4 was higher in LT4 treated group (p = 0 .0 0 5 ), with TAI, and newborns in this group had higher birth weight (p = 0.001) and height (p = 0 .0 0 8 ). Maternal complications occurred in 23.8% of patients. No congenital malformations in newborns were noted. Conclusions: Thyroid autoantibodies present in FF may have an effect on the post-implantation embryo development, but have no effect on further course of pregnancy. The special benefit of LT4 treatment for successful A R T outcome was demonstrated for newborn anthropometric parameters.
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- 2023
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5. Thermal degradation kinetics of myrtle leaves ethanol extract (Myrtus communis L.): effect on phenolic compounds content and antioxidant activity
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Snoussi, Ahmed, Bouacida, Saoussen, Mitić, Milan, Arsić, Biljana, Koubaier, Hayet Ben Haj, Chouaibi, Moncef, Janković, Sonja, Zlatanović, Ivana, Mrmošanin, Jelena, Stojanović, Gordana, and Bouzouita, Nabiha
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- 2022
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6. Optimization of the reaction conditions for the synthesis of 2,3,5-trimethylpyridine from 3-amino-2-methylpropenal and methylethylketone
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Urošević Jovica, Mitić Miroslav, Arsić Biljana, and Stojanović Gordana
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cyclic condensation ,gc-ms ,side reactions ,Chemistry ,QD1-999 - Abstract
The influence of temperature, reaction time, and type of the catalyst on the yield of the 2,3,5-trimethylpyridine (collidine) from 3-amino-2-methylpropenal and methylethylketone was investigated. 3-Amino-2-methylpropenal was synthesized from 3-ethoxy-2-methylacrolein previously synthesized from methylmalondialdehyde tetraethyl acetal, obtained from triethyl orthoformate and propenyl ether. The optimal conditions for the investigated synthesis were temperature of 150 °C, reaction time 24 h, and the CH3COOH/pTsOH catalyst. This synthesis is the first successful attempt to synthesize 2,3,5-trimethylpyridine in an acid medium.
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- 2022
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7. Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs
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Lukić Vera, Micić Ružica, Arsić Biljana, Nedović Bojan, and Radosavljević Živana
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illegal drugs ,cathinones ,phenethylamines ,cannabinoids ,tryptamines ,Chemistry ,QD1-999 - Abstract
The misuse of psychoactive substances is attracting a great deal of attention from the general public. An increase use of psychoactive substances is observed among young people who do not have enough awareness of the harmful effects of these substances. Easy access to illicit drugs at low cost and lack of effective means of routine screening for new psychoactive substances (NPS) have contributed to the rapid increase in their use. New research and evidence suggest that drug use can cause a variety of adverse psychological and physiological effects on human health (anxiety, panic, paranoia, psychosis, and seizures). We describe different classes of these NPS drugs with emphasis on the methods used to identify them and the identification of their metabolites in biological specimens. This is the first review that thoroughly gives the literature on both natural and synthetic illegal drugs with old known data and very hot new topics and investigations, which enables the researcher to use it as a starting point in the literature exploration and planning of the own research. For the first time, the conformational analysis was done for selected illegal drugs, giving rise to the search of the biologically active conformations both theoretically and using lab experiments.
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- 2021
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8. DFT calculations as an efficient tool for prediction of Raman and infra-red spectra and activities of newly synthesized cathinones
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Vujović Maja, Ragavendran Venkatesan, Arsić Biljana, Kostić Emilija, and Mladenović Milan
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cathinones ,dft ,spectra ,reactivity ,Chemistry ,QD1-999 - Abstract
Initially made for medical treatment for Parkinsonism, obesity, and depression, cathinones have become illegal drugs for the “recreational use”. The mechanism of action of synthetic cathinones consists of the inhibition of monoamine transporters. DFT (Density Functional Theory) calculations on the selected cathinones (3-FMC, 4-FMC, 4-MMC, Buphedrone, Butylone, Ethylone, MDPV, Methcathinone, and Methylone) were performed using B3LYP level of the Gaussian 09 program suite. The unscaled B3LYP/6–31G vibrational wavenumbers are in general larger than the experimental values, so the use of selective scaling was necessary. The calculated spectra of selected cathinones are in good correlation with the experimental spectra which demonstrates that DFT is a good tool for the prediction of spectra of newly synthesized and insufficiently experimentally characterised cathinones. Also, HOMO-LUMO (Highest Occupied Molecular Orbital-Lowest Unoccupied Molecular Orbital) analysis shows that 3-FMC possesses the minimum energy gap of 3.386 eV, and the molecule 4-FMC possesses the maximum energy gap of 4.205 eV among the investigated cathinones. It indicates that 3-FMC would be highly reactive among all the cathinones under investigation.
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- 2020
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9. Kinetic models of the extraction of vanillic acid from pumpkin seeds
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Mitić Milan, Janković Sonja, Mašković Pavle, Arsić Biljana, Mitić Jelena, and Ickovski Jovana
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extraction yield ,vanillic acid ,pumpkin seed ,ponomarev model ,Chemistry ,QD1-999 - Abstract
Vanillic acid is used in the food industry and perfumery, and the optimization of its extraction process from the natural source is important for saving time and money. The presence of vanillic acid in pumpkin seeds was proven using HPLC analysis. Computational optimization of the extraction shows that for the concentration of ethanol 40% and solmodul: V/m=20, the optimum condition for the extraction of vanillic acid from pumpkin seeds was 100 min and 450C. The estimation of fitting for each kinetic model to the experimental kinetic data was performed using the root mean square, standard deviation, and the correlation coefficient. Ponomarev model was shown as the most suitable with the highest accuracy among the six considered kinetic models. The enthalpy and entropy changes were positive, while the Gibbs free energy was negative and decreased when temperature increased during the thermodynamic analysis. Therefore, the extraction of vanillic acid from pumpkin seeds was endothermic, spontaneous, and irreversible.
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- 2020
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10. Synthesis and characterization of cinnamylidene acetone – A study on tuning of band gap by vibrational spectroscopic tools
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Ragavendran, V., Muthunatesan, S., Santhanam, V., and Arsic, Biljana
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- 2019
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11. Evaluation of an Inductively Coupled Plasma–Atomic Emission Spectrometry (ICP-AES) Method for the Determination of Macro and Microelements in Trifolium L. Species.
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Mrmošanin, Jelena, Pavlović, Aleksandra, Rašić Mišić, Ivana, Tošić, Snežana, Petrović, Stefan, Mitić, Zorica, Pecev-Marinković, Emilija, and Arsić, Biljana
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CLOVER ,SPECTROMETRY ,GAS flow ,COPPER ,SPECIES ,SILICON ,TRACE elements - Abstract
This study aimed optimizes the inductively coupled plasma–atomic emission spectrometry (ICP-AES) conditions for the determination of macro and microelements in the flowers and leaves of Trifolium species. After the optimization of instrumental parameters, plasma robustness was achieved under the following conditions: RF power 1350 W, nebulizer flow rate 0.5 L min
−1 , coolant gas flow rate 12 L min−1 , auxiliary gas flow rate 0.5 L min−1 , flush pump rate 100 rpm, analysis pump rate 50 rpm, sample flow 0.5 mL min−1 , and sample uptake delay 30 s. The limits of detection (LOD) and limits of quantification (LOQs) were lower than literature values. The most abundant microelement in leaves is Ca, followed by K, Mg, P, and Na, and in flowers was K, followed by Ca, P, Mg, and Na. The average contents of microelements decreased in the orders S > Fe > Si > Al > Zn > Mn > Cu > Ni > Co > Pb > Cr > As > Cd for flowers and S > Fe > Si > Mn > Al > Zn > Cu > Ni > Co > Pb > Cr > As > Cd for leaves. Chemometrics were used for grouping samples based upon the elemental contents. [ABSTRACT FROM AUTHOR]- Published
- 2024
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12. New Facts on the Antimicrobial Essential Oil of Satureja kitaibelii.
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Dimitrijević, Marija V., Miladinović, Ljiljana C., Marković, Marija S., Arsić, Biljana, Mihajilov‐Krstev, Tatjana M., and Miladinović, Dragoljub L.
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- 2024
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13. 16-membered macrolide antibiotics: a review
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Arsic, Biljana, Barber, Jill, Čikoš, Ana, Mladenovic, Milan, Stankovic, Nevena, and Novak, Predrag
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- 2018
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14. Phenolic profiles and metal ions analyses of pulp and peel of fruits and seeds of quince (Cydonia oblonga Mill.)
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Stojanović, Branka T., Mitić, Snežana S., Stojanović, Gordana S., Mitić, Milan N., Kostić, Danijela A., Paunović, Dušan Ɖ., Arsić, Biljana B., and Pavlović, Aleksandra N.
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- 2017
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15. Author Correction: Influence of the magnetic field on bandgap and chemical composition of zinc thin films prepared by sparking discharge process
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Ručman, Stefan, Intra, Panich, Kantarak, E., Sroila, W., Kumpika, T., Jakmunee, J., Punyodom, W., Arsić, Biljana, and Singjai, Pisith
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- 2020
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16. Influence of the magnetic field on bandgap and chemical composition of zinc thin films prepared by sparking discharge process
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Ručman, Stefan, Intra, Panich, Kantarak, E., Sroila, W., Kumpika, T., Jakmunee, J., Punyodom, W., Arsić, Biljana, and Singjai, Pisith
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- 2020
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17. Chemometric and ICP-OES analyses of Forsythia europaea Degen & Bald. and its extracts.
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KOSTIĆ, Danijela, ARSIĆ, Biljana B., TOŠIĆ, Snežana, PAVLOVIĆ, Aleksandra, PECEV MARINKOVIĆ, Emilija, TASIĆ, Milena, and STOJANOVIĆ, Gordana
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TRANSITION metals , *PRINCIPAL components analysis , *CHEMOMETRICS , *COPPER , *HEAVY metals , *HIERARCHICAL clustering (Cluster analysis) - Abstract
Forsythia represents a group of plants originating mainly from China and Japan, but one species is endemic and grows in the Balkans (Balkan forsythia, Forsythia europaea Degen & Bald.). Our previous studies on polyphenols in investigated extracts of Balkan forsythia showed that this plant is a good source of polyphenols. Analysis of the various extracts of Balkan forsythia (Forsythia europaea Degen & Bald.) by the application of ICP-OES method showed that they are rich in different macro and microelements. The abundance order of macroelements is K>Ca>P>Mg>Na in all extracts. Among the transition metals iron, manganese, zinc and copper are particularly important, and the order of abundance is Zn>Fe>Cu>Mn. Heavy metals which are the most frequent contaminants of food are lead, cadmium and arsenic, and the determination of their contents is of special importance on the safe use of plant species. The determination shows that aqueous extracts contain the highest quantity of elements, which is especially important. The contents of toxic elements are significantly lower than the permitted values. Statistical methods (Principal Component Analysis (PCA) and Agglomerative Hierarchical Clustering (AHC)) are useful tools for the grouping of samples and determining relations between investigated elements. This analysis shows that when higher quantities of Cr and Ba are present, the lower quantities of V are present, and vice versa. Based on our studies on polyphenols and minerals, we can expect the anti-inflammatory effects of extracts of Balkan forsythia. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Correlation Analysis of Heavy Metals Contents of Malva sylvestris L. plant and Its Extracts from Polluted and Non-polluted Locations in Niš, Republic of Serbia
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Kostic, Danijela, Arsić, Biljana, Ranđelović, Saša, Pavlović, Aleksandra, Tošić, Snežana, and Stojanović, Gordana
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- 2019
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19. Molecular Docking Assessment of Cathinones as 5-HT 2A R Ligands: Developing of Predictive Structure-Based Bioactive Conformations and Three-Dimensional Structure-Activity Relationships Models for Future Recognition of Abuse Drugs.
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Tomašević, Nevena, Vujović, Maja, Kostić, Emilija, Ragavendran, Venkatesan, Arsić, Biljana, Matić, Sanja Lj., Božović, Mijat, Fioravanti, Rossella, Proia, Eleonora, Ragno, Rino, and Mladenović, Milan
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STRUCTURE-activity relationships ,MOLECULAR docking ,DRUG abuse ,QSAR models ,LIGANDS (Biochemistry) ,MOLECULAR recognition - Abstract
Commercially available cathinones are drugs of long-term abuse drugs whose pharmacology is fairly well understood. While their psychedelic effects are associated with 5-HT
2A R, the enclosed study summarizes efforts to shed light on the pharmacodynamic profiles, not yet known at the receptor level, using molecular docking and three-dimensional quantitative structure–activity relationship (3-D QSAR) studies. The bioactive conformations of cathinones were modeled by AutoDock Vina and were used to build structure-based (SB) 3-D QSAR models using the Open3DQSAR engine. Graphical inspection of the results led to the depiction of a 3-D structure analysis-activity relationship (SAR) scheme that could be used as a guideline for molecular determinants by which any untested cathinone molecule can be predicted as a potential 5-HT2A R binder prior to experimental evaluation. The obtained models, which showed a good agreement with the chemical properties of co-crystallized 5-HT2A R ligands, proved to be valuable for future virtual screening campaigns to recognize unused cathinones and similar compounds, such as 5-HT2A R ligands, minimizing both time and financial resources for the characterization of their psychedelic effects. [ABSTRACT FROM AUTHOR]- Published
- 2023
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20. Broad-spectrum of antimicrobial properties of commercial wines from different Vitis vinifera L. varieties
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Radovanović, Aleksandra, Arsić, Biljana, Radovanović, Vladimir, Jovančičević, Branimir, and Nikolić, Vesna
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- 2017
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21. In Silico Investigation of Selected Pesticides and Their Determination in Agricultural Products Using QuEChERS Methodology and HPLC-DAD.
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Petrović, Stefan, Arsić, Biljana, Zlatanović, Ivana, Milićević, Jelena, Glišić, Sanja, Mitić, Milan, Đurović-Pejčev, Rada, and Stojanović, Gordana
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FARM produce , *PESTICIDES , *PESTICIDE residues in food , *EMAMECTIN benzoate , *ALZHEIMER'S disease , *CHLORANTRANILIPROLE , *AGRICULTURE - Abstract
In this study, we considered some pesticides as active substances within formulations for the protection of plant-based food in the Republic of Serbia in silico, because these pesticides have not often been investigated in this way previously, and in an analytical way, because there are not very many available fast, cheap, and easy methods for their determination in real agricultural samples. Seven pesticides were detected in selected agricultural products (tomatoes, cucumbers, peppers, and grapes) using the QuEChERS methodology and HPLC-DAD. Standard curves for the investigated pesticides (chlorantraniliprole, methomyl, metalaxyl, thiacloprid, acetamiprid, emamectin benzoate, and cymoxanil) show good linearity, with R2 values from 0.9785 to 0.9996. The HPLC-DAD method is fast, and these pesticides can be determined in real spiked samples in less than 15 min. We further characterized the pesticides we found in food based on physicochemical properties and molecular descriptors to predict the absorption, distribution, metabolism, elimination, and toxicity (ADMET) of the compounds. We summarized the data supporting their effects on humans using various computational tools to determine their potential adverse effects. The results of our prediction study show that all of the selected pesticides considered in this study have good oral bioavailability, and those with high toxicity, therefore, could be harmful to human health. Chlorantraniliprole was shown in a molecular docking study as a good starting point for a new Alzheimer's disease drug candidate. [ABSTRACT FROM AUTHOR]
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- 2023
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22. Examination of possible role of the chlamydial stress proteins in pathogenesis of ectopic pregnancy
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Vivoda Maja, Arsić Biljana, Garalejić Eliana, Ćirković Ivana, and Đukić Slobodanka
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Chlamydia ,ectopic pregnancy ,stress proteins ,Medicine - Abstract
Introduction. Chlamydia trachomatis infections are the most prevalent bacterial sexually transmitted infections recognized throughout the world. In the last few years, several studies have indicated that predisposition of C. trachomatis to persist within the host cell is recognized as a major factor in the pathogenesis of chlamydial infection. During persistent chlamydial infection, the stress protein hsp60 is synthesized continually as immunopathologic antigen. Antibodies to hsp60 are found in women with tubal occlusion, but these antibodies are not detected in women with the acute C. trachomatis infection, which indicates that hsp60 has an important role in pathogenesis of persistant chlamydial infection. Objective. The aim of this study was to determine the role of chlamydial stress proteins (heat shock proteins) in pathogenesis of ectopic pregnancy. Methods. The study included 40 women with ectopic pregnancy (experimental group) and 34 women with normal pregnancy (control group). C. trachomatis was detected in endocervical smears by direct immunofluorescence test, while specific antibodies against Chlamydia spp. and against hsp60 were detected by ELISA. Results. DIF method detected the presence of C. trachomatis in 12.5% of women with the ectopic pregnancy and 17.6% of women with normal pregnancy. IgG antibodies against Chlamydia spp. were found in 57.5% of women with the ectopic pregnancy and 26.5% of women with normal pregnancy. IgA antibodies were positive in 37.5% of women with the ectopic pregnancy and 2.9% of women with normal pregnancy. IgG antibodies against hsp60 were positive in 37.5% of women with the ectopic pregnancy and 14.7% of women with normal pregnancy. Conclusion. The results of this study have proven the correlation between the ectopic pregnancy and the presence of IgG antibodies to chlamydial hsp60.
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- 2014
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23. Diagnosis of bacterial vaginosis
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Đukić Slobodanka, Ćirković Ivana, Arsić Biljana, and Garalejić Eliana
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bacterial vaginosis ,vaginal flora ,diagnosis ,Medicine - Abstract
Bacterial vaginosis is a common, complex clinical syndrome characterized by alterations in the normal vaginal flora. When symptomatic, it is associated with a malodorous vaginal discharge and on occasion vaginal burning or itching. Under normal conditions, lactobacilli constitute 95% of the bacteria in the vagina. Bacterial vaginosis is associated with severe reduction or absence of the normal H2O2producing lactobacilli and overgrowth of anaerobic bacteria and Gardnerella vaginalis, Atopobium vaginae, Mycoplasma hominis and Mobiluncus species. Most types of infectious disease are diagnosed by culture, by isolating an antigen or RNA/DNA from the microbe, or by serodiagnosis to determine the presence of antibodies to the microbe. Therefore, demonstration of the presence of an infectious agent is often a necessary criterion for the diagnosis of the disease. This is not the case for bacterial vaginosis, since the ultimate cause of the disease is not yet known. There are a variety of methods for the diagnosis of bacterial vaginosis but no method can at present be regarded as the best. Diagnosing bacterial vaginosis has long been based on the clinical criteria of Amsel, whereby three of four defined criteria must be satisfied. Nugent’s scoring system has been further developed and includes validation of the categories of observable bacteria structures. Uptodate molecular tests are introduced, and better understanding of vaginal microbiome, a clear definition for bacterial vaginosis, and shortterm and longterm fluctuations in vaginal microflora will help to better define molecular tests within the broader clinical context.
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- 2013
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24. Results of modern tuboperitoneal infertility treatment
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Turjačanin-Pantelić Drenka, Bojović-Jović Dragana, Arsić Biljana, and Garalejić Eliana
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infertility, female ,laparotomy ,laparoscopy ,gynecologic surgical procedures ,treatment, outcome ,pregnancy ,abortion, spontaneous ,parturition ,Medicine (General) ,R5-920 - Abstract
Background/Aim. A modern approach to surgical treatment of tuboperitoneal infertility is based on laporascopic techniques. The aim of this study was to compare results of tuboperitoneal infertility treatment by the use of laparoscopy and classical laparotomy. Methods. A retrospectiveprospective study on 66 women treated operatively form tuboperitoneal infertility was performed. Data from patient's anamnesis and those related to the surgical treatment results, obtained by the use of an inquiry, were used in retrospective and prospective analysis, respectively. Chi-square test was used in statistical analysis. P value < 0.05 was considered significant. Results. Classical laparotomy was used on 34 women in a period from 1996 to 1997, while 32 women were operated laparoscopically in a period from 1999 to 2000. The results were as follows: a total number of conceived women was 16 (24%), seven in the group I (20.6%) and nine in the group II (28.1%); 13 women were with one pregnancy, six in the group I (17.6%) and seven in the group II (22%). Twice pregnant were three women, one in the group I (2.9%) and two in the group II (6.2%). The resulting pregnancies were: five women with abortion spontaneous, two in the group I (5.9%) and three in the group II (9.4%); two women with extrauterine pregnancy in the group I (5.9%); three with pretemporal birth, one in the group I (2.9%) and two in the group II (6.2%), while six women were with the temporal birth, two in the group I (5.9%) and four in the group II (12.5%). Statistical analysis showed that there was no significant difference in the results between these two groups. Conclusion. Surgical treatment of tubeperitoneal infertility, regardless of the used methods (classical laparotomy or laparoscopy) was successful in a great number of women. These methods have a great advantage over in vitro fertilization, and they should not be ignored.
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- 2009
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25. A rapid and reliable determination of doxycycline hyclate by HPLC with UV detection in pharmaceutical samples
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Mitić Snežana S., Miletić Gordana Ž., Kostić Danijela A., Nasković-Ðokić Daniela Č., Arsić Biljana B., and Rašić Ivana D.
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high performance liquid chromatography ,doxycycline hyclate ,ultraviolet detection ,Chemistry ,QD1-999 - Abstract
An accurate, sensitive and reproducible high performance liquid chromatographic (HPLC) method for the quantification of doxycycline hyclate in pharmaceutical samples has been developed and validated. The drug and the standard were eluted from a Lichrosorb RP-8 (250 mm x 4.6 mm, 10 mm particle size) at 20°C with a mobile phase consisting of methanol, acetonitrile and 0.010 M aqueous solution of oxalic acid (2:3:5, v/v/v). The flow rate was 1.25 ml min-1. A UV detector set at 350 nm was used to monitor the effluent. Each analysis required no longer than 4 min. The limits of detection and quantification were 1.15 and 3.84 µg ml-1, respectively. Recoveries for different concentrations ranged from 99.58 to 101.93%.
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- 2008
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26. Quantitative analysis of ibuprofen in pharmaceuticals and human control serum using kinetic spectrophotometry
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Mitić Snežana S., Miletić Gordana Ž., Pavlović Aleksandra N., Arsić Biljana B., and Živanović Valentina V.
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ibuprofen ,kinetic spectrophotometry ,validation ,pharmaceutical preparation. ,Chemistry ,QD1-999 - Abstract
The aim of this work was to develop a new kinetic spectrophotometric method for the determination of ibuprofen in pharmaceutical formulations. Ibuprofen was determined in an acidic ethanolic medium by monitoring the rate of appearance of 1-nitroso-2-naphthol, resulting from the displacement by ibuprofen of Co(III) from the tris(1-nitroso-2-naptholato)cobalt(III) complex. The optimum operating conditions regarding reagent concentrations and temperature were established. The tangent method was adopted for constructing the calibration curve, which was found to be linear over the concentration range 0.21-1.44 and 1.44-2.06 µg ml-1. The optimized conditions yielded a theoretical detection limit of 0.03 µg ml-1 based on the 3.3 S0 criterion. The interference effects of the usual excipients of powdery drugs, foreign ions and amino acids on the reaction rate were studied in order to assess the selectivity of the method. The developed procedure was successfully applied for the rapid determination of ibuprofen in commercial pharmaceutical formulations and human control serum. The unique features of this procedure are that the determination can be performed at room temperature and the analysis time is short. The newly developed method is simple, inexpensive and efficient for use in the analysis of a large number of samples.
- Published
- 2008
- Full Text
- View/download PDF
27. Chemometric Approach to the Composition of Flavonoid Compounds and Phenolic Acids and Antioxidant Potential of Artemisia Species from Different Habitats.
- Author
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Ickovski, Jovana D., Arsić, Biljana B., Mitić, Milan N., Stojković, Milan B., Đorđević, Milan M., and Stojanović, Gordana S.
- Published
- 2022
- Full Text
- View/download PDF
28. Benzenoid isomers with greatest and smallest Kekulé structure counts
- Author
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Gutman Ivan, Arsić Biljana, Denić Marija, and Stojanović Ivana
- Subjects
kekulé structure ,kekulé structure count ,benzenoid hydrocarbons ,Chemistry ,QD1-999 - Abstract
In families of benzenoid isomers, the species with the greatest and smallest value of the Kekulé structure count (K) possess, respectively, the greatest and smallest thermodynamic stability and, respectively, the smallest and greates reactivity. In this paper the structure of the isomers with extremal K-values for the benzenoid molecules A = A(a, b, c, d, e) (with the formula C4h+2H2h+4) and B1 = B1(a, b, c, d)& B2 = B2(a, b, c, d) (with formula C4hH2h+2) were determined. The system A is obtained by attaching linear polyacene fragments of length a, b, c, and d to a linear polyacene of length e + 2, so that h = a + b + c + d + e + 2, the number of hexagons of A, is constant. The systems B1 and B2 are obtained by attaching linear polyacene fragments of length a, b, c, and d to pyrene, in two different ways, so that h = a + b + c + d + 4, the number of hexagons of B1 and B2, is constant. The main conclusion is that K is maximal if the parameters a, b, c, d differ by at most one, and that K is minimal if b, c, d are equal to zero.
- Published
- 2006
- Full Text
- View/download PDF
29. On the relation between Zenkevich and Wiener indices of alkanes
- Author
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Gutman Ivan, Furtula Boris, Arsić Biljana, and Bošković Žarko
- Subjects
zenkevich index ,wiener index ,alkanes ,Chemistry ,QD1-999 - Abstract
A relatively complicated relation was found to exist between the quantity U recently introduced by Zenkevich (providing a measure of internal molecular energy), and the Wiener index W (measuring molecular surface area and intermolecular forces). We now report a detailed analysis of this relation and show that, in the case of alkanes, its main features are reproduced by the formula U = –αW + β + γν1; where ν1 is the number of methyl groups, and α, β and γ are constants, depending only on the number of carbon atoms. Thus for isomeric alkanes with the same number of methyl groups, U and W are linearly correlated.
- Published
- 2004
- Full Text
- View/download PDF
30. Equiseparable chemical trees
- Author
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Gutman Ivan, Arsić Biljana, and Furtula Boris
- Subjects
wiener index ,variable wiener index ,chemical trees ,alkanes ,equiseparability ,Chemistry ,QD1-999 - Abstract
Let n1(e|T) and n2(e|T) denote the number of vertices of a tree T, lying on the two sides of the edge e. Let T1 and T2 be two trees with equal number of vertices, let e be an edge of T1 and f an edge of T2. Then e and f are said to be equiseparable if either n1(e|T1) = n1(f|T2) or n1(e|T1) = n2(f|T2). If all edges of T1 and T2 can be chosen so as to form equiseparable pairs, then T1 and T2 are equiseparable trees. A number of molecular structure-descriptors of equiseparable chemical trees coincide, implying that the corresponding alkane isomers must have similar physico-chemical properties. It is shown how equiseparable chemical trees can be constructed in a systematic manner. .
- Published
- 2003
- Full Text
- View/download PDF
31. Free and bound state structures of 6- O-methyl homoerythromycins and epitope mapping of their interactions with ribosomes
- Author
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Novak, Predrag, Barber, Jill, Čikoš, Ana, Arsic, Biljana, Plavec, Janez, Lazarevski, Gorjana, Tepeš, Predrag, and Košutić-Hulita, Nada
- Published
- 2009
- Full Text
- View/download PDF
32. Woman with surgical reconstruction of anal atresia who realized pregnancy with in vitro fertilisation
- Author
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Garalejić Eliana, Arsić Biljana, Bojović-Jović Dragana, Veljković Milija, Macanović Biljana, Pavlović Dejan, Vasić Bojan, and Lekić Dragana
- Subjects
anus, imperforate ,fertilization in vitro ,pregnancy outcome ,Medicine (General) ,R5-920 - Abstract
Introduction. Anal atresia is a congenital anomaly, very life threatening and urgent. Surgical treatment of this anomaly consists of colostomy first, and then of anal reconstruction. Case report. We presented a 31-year old female with the surgery treatment of anal atresia in the early childhood. In the reproductive period, due to tubal infertily, the patient was included in the program of in vitro fertilization (IVF), in the Clinic for Gynecology and Obstetrics 'Narodni front', Belgrade. Within this program a long protocol of ovarian stimulation was performed. Ultrasonographic and color Doppler monitoring of the patient was applied by the use of an ultrasonographic apparatus type Siemens Acuson X 150, while any hormonal examinations were performed by an Architect Abbott unit. During the IVF program, the growth of follicules was controlled by the use of ultrasonography, microcirculation of the ovaries and the uterus was marked by a power-pulsating color Doppler, and hormonal examination was performed starting from the day of stimulation up to the day of injecting Pregnyl®. The patient was administered Suprefact® (buserelin) sc from the 21st day of the menstrual cycle, as well as from the 3rd day of the cycle, for totally 11 days. The patient was given 29 ampoules of Gonal F® (recombinant human FSH) 75 IJ im and 15 ampoules of Menopur® (menotrophin) im. Due to a modified pelvic anatomy, the left ovary aspiration was disabled, while the right ovary aspired seven oocytes successfully. Three embryos were inserted in the uterus. The delivery was performed by cesarean section. Conclusion. In the reported patient with a modified pelvic anatomy due to four corrective surgeries of anal atresia, and tubal infertility in the reproductive period, the method of choice for the realization of pregnancy was the IVF procedure. The realized pregnancy and the delivery could be considered highly successful in regard to possible risks.
- Published
- 2010
- Full Text
- View/download PDF
33. Conformational probe: static quenching is reduced upon acid triggered ring flip of a myo-inositol derivative
- Author
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Kadirvel, Manikandan, Gbaj, Abdul, Mansell, David, Miles, Steven M., Arsic, Biljana, Bichenkova, Elena V., and Freeman, Sally
- Published
- 2008
- Full Text
- View/download PDF
34. Quantitative determination of glycine in commercial dosage forms by kinetic spectrophotometry
- Author
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Mitić, Snežana S., Pavlović, Aleksandra N., Tošić, Snežana B., Arsić, Biljana B., and Sunarić, Slavica M.
- Published
- 2009
- Full Text
- View/download PDF
35. ANTIMICROBIAL ACTIVITY AND THE QUANTITATIVE ANALYSES OF PHENOLIC COMPOUNDS AND HEAVY METALS OF RED MULBERRY EXTRACTS (MORUS RUBRA L.) FROM SERBIA.
- Author
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DIMITRIJEVIĆ, DANICA, KOSTIĆ, DANIJELA, PAUNOVIĆ, DUŠAN, MITIĆ, MILAN, KRSTIĆ, JOVANA, MIŠIĆ, IVANA RAŠIĆ, and ARSIĆ, BILJANA
- Subjects
HEAVY metals ,PHENOLS ,ATOMIC absorption spectroscopy ,MULBERRY ,METAL compounds ,CHLOROGENIC acid - Abstract
All investigated extracts of red mulberry (Morus rubra L.) contain a high content of total phenols. The highest content of total phenols was shown by red mulberry in the ethanolic extract (50%). Certain extracts of the fruit of red mulberry (aqueous, ethanolic 50%, acetonic 50% and acetonic) contain very small quantities of anthocyanins. Four phenolic acids were identified in the extracts of red mulberry: chlorogenic, neochlorogenic, cryptochlorogenic acid and caffeic acid, and four flavonoids using HPLC analysis: quercetin-3-O-rutinoside, quercetin-3-O-glucoside, quercetin-3-Orhamnoside, and kaempferol-3-O-rutinoside. Cyanidin-3-O-glucoside was identified in the methanolic extract of red mulberry. The content of heavy metals (Fe, Cu, Mn, Cd, Ni, Zn and Pb) was determined using atomic absorption spectroscopy in fruits and the extracts of red mulberry. Mulberry fruit has been shown the highest content of Fe and low content of toxic metals. The content of metals is the highest in the majority of cases in the extracts of acetone and acetone 50%. The methanolic extract of red mulberry shows the antimicrobial properties against all investigated bacteria except Staphylococcus aureus. Obtained results show that fresh fruits of red mulberry and its extracts can be used in nutrition and the preparation of pharmaceutical formulations. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
36. The kinetic and thermodynamic studies of solid-liquid extraction of apigenin-glycosides from parsley (Petroselinum crispum).
- Author
-
Janković, Sonja, Mitić, Milan, Arsić, Biljana, and Stankov-Jovanović, Vesna
- Subjects
PARSLEY ,GIBBS' free energy ,HIGH performance liquid chromatography ,ROOT-mean-squares ,LIQUID analysis ,SOLVENT extraction - Abstract
In this study, the effect of various parameters such as solvent concentration (50 and 80%), extraction temperature (30, 40, and 50°C), and solvent/solid ratio (1:20, 1:25, and 1:30 g ml
−1 ) on the extraction yield of apigenin-glycosides from parsley were investigated. The high-performance liquid chromatography analysis of parsley extracts confirms the presence of two apigenin-glycosides: apiin and malonyl-apiin. The kinetics of extraction was described using non-stationary diffusion model and Ponomarev's model. Models have a good fit to the experimental data (root mean square: RMS<±1.6%; standard deviation: SD<±1.5%; the coefficient of determination: R2 > 0.82). The effects of the process factors on the kinetic model parameters, equilibrium constant and Gibbs free energy change were assessed using the full factorial test plan 23 . [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
37. Antibacterial activities of fruits extracts of three mulberry species (Morus alba L., Morus rubra L. and Morus nigra L.) and bilberry (Vaccinium myrtillus L.)
- Author
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Miljković, Vojkan, Nikolić, Goran, Mihajlov-Krstev, Tatjana M., and Arsić, Biljana
- Subjects
antimicrobial activity ,Morus nigra L ,Morus alba L ,Morus rubra L ,Vaccinium myrtillus L - Abstract
Delphinidin is a dominant anthocyanidin in bilberry. Antimicrobial activity of methanol extracts of the genus Morus showed that M. nigra L. extract was more active than extracts of other two species (M. alba L. and M. rubra L.). Minimal inhibitory and bactericidal concentration of V. myrtillus methanol extract was in the range of MIC/MBC = 15.75-252.00 mg/mL. Antimicrobial effect of the tested extracts was less potent against strains from wounds compared to ATCC strains as well Gram (-) bacteria compared to Gram (+) bacteria. The most sensitive strains were S. epidermidis, S. pyogenes. P. mirabilis and S. aureus.
- Published
- 2018
38. PRINCIPAL COMPONENT ANALYSIS AND THERMOMECHANICAL PREFERENCE OF WHITE Au ALLOYS WITHOUT Ag.
- Author
-
MIRIĆ, MLADEN, ARSIĆ, BILJANA, ĐORĐEVIĆ, MILOŠ, ĐORĐEVIĆ, DRAGAN, GUSKOVIĆ, DRAGOSLAV, and IVANOV, SVETLANA
- Subjects
SILVER alloys ,PRINCIPAL components analysis ,GOLD alloys ,ALLOYS ,ELECTRIC conductivity - Abstract
Addition of different amounts of Cu and Ag to Au alloys, as well as some new elements (Zn and Cd), gives alloys of the different colour spectrum (from red to yellow) and different technological and metallurgical characteristics. The trend today is the implementation of new alloys not containing Ag, and including new elements, such as Ga and In. Differences in two Au alloys exist: the first alloy contains Ni and Pd, and the second alloy is without them. The values of electrical conductivity and hardness are different, due to the reduction, which was shown using PCA (r=0.985 and the strong positive correlation between hardness and electrical conductivity). Performed tests confirm that those multiphase multi component gold alloys can find their application not only in jewellery making but also in the world of modern electrical engineering. The performed statistical analysis shows strong positive and negative correlations of properties of investigated Au alloys, and it provides significant savings in the design and efficiency of metallurgical processes. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
39. Optimization of the Solid-Liquid Extraction Process of Phenolic Compounds from Mulberry Fruit.
- Author
-
KOSTIĆ, Emilija, ARSIĆ, Biljana, MITIĆ, Milan, DIMITRIJEVIĆ, Danica, and PECEV MARINKOVIC, Emilija
- Subjects
- *
MULBERRY , *PHENOLS , *WHITE mulberry , *EXTRACTION techniques , *SOLVENT extraction , *FRUIT - Abstract
The study was designed to examine the influence of solvent concentration (ethanol/water 20-80% by volume), extraction time (15-240 min) and extraction technique on the extraction yield of phenolic compounds, flavonoids and antioxidant activity from Morus nigra L., Morus rubra L. and Morus alba L. fruits. The optimum conditions for the extraction of total phenols, flavonoids and monomeric anthocyanins by the maceration and ultrasonic extraction processes were: 213.6 min with 80% ethanol, and 182.1 min and 71.2% ethanol, respectively (black mulberry), and 216.5 min with 78.3% ethanol and 198.7 min and 70.6% ethanol, respectively (red mulberry). In case of white mulberry for the extraction of total phenols and flavonoids optimum extraction conditions (maceration and ultrasonic) were 232.7 min and 80% ethanol, and 187.2 min and 68.7% ethanol, respectively (white mulberry). Obviously, ultrasonic extraction was less time consuming, and it requires for all performed extractions solvent with less percentage of ethanol. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
40. Chemometrics based on the mineral content as a tool for the assessment of the pollution of top soils.
- Author
-
Simonović, Strahinja, Sejmanović, Dragana, Micić, Ružica, Arsić, Biljana, Pavlović, Aleksandra, Mitić, Snežana, Jokić, Anja, Valjarević, Aleksandar, and Micić, Aleksandar
- Subjects
TRACE elements ,SOIL pollution ,CHEMOMETRICS ,MULTIPLE correspondence analysis (Statistics) - Abstract
This is the first research of this type which includes the wider area of Kosovo taking into account the mineral wealth. The concentrations of 20 elements: Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, Ni, P, Pb, Se, Si, V, and Zn were determined using ICP-OES. The ranges of concentrations of toxic elements are lead (Pb) 0.044–14.98 g/kg, arsenic (As) 0.007–0.33 g/kg, cadmium (Cd) 0.004–0.044 g/kg, and chromium (Cr) 0.053–0.245 g/kg. The spatial distribution of toxic elements was described using distribution maps. Principal component and cluster analyses were performed to reveal grouping of samples. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
41. The Targeted Pesticides as Acetylcholinesterase Inhibitors: Comprehensive Cross-Organism Molecular Modelling Studies Performed to Anticipate the Pharmacology of Harmfulness to Humans In Vitro.
- Author
-
Mladenović, Milan, Arsić, Biljana B., Stanković, Nevena, Mihović, Nezrina, Ragno, Rino, Regan, Andrew, Milićević, Jelena S., Trtić-Petrović, Tatjana M., and Micić, Ružica
- Subjects
- *
PESTICIDES , *ACETYLCHOLINESTERASE , *ACETYLCHOLINESTERASE inhibitors , *PROTEASE inhibitors , *PHARMACOLOGY - Abstract
Commercially available pesticides were examined as Mus musculus and Homo sapiens acetylcholinesterase (mAChE and hAChE) inhibitors by means of ligand-based (LB) and structure-based (SB) in silico approaches. Initially, the crystal structures of simazine, monocrotophos, dimethoate, and acetamiprid were reproduced using various force fields. Subsequently, LB alignment rules were assessed and applied to determine the inter synaptic conformations of atrazine, propazine, carbofuran, carbaryl, tebufenozide, imidacloprid, diuron, monuron, and linuron. Afterwards, molecular docking and dynamics SB studies were performed on either mAChE or hAChE, to predict the listed pesticides' binding modes. Calculated energies of global minima (Eglob_min) and free energies of binding (ΔGbinding) were correlated with the pesticides' acute toxicities (i.e., the LD50 values) against mice, as well to generate the model that could predict the LD50s against humans. Although for most of the pesticides the low Eglob_min correlates with the high acute toxicity, it is the ΔGbinding that conditions the LD50 values for all the evaluated pesticides. Derived pLD50 = f(ΔGbinding) mAChE model may predict the pLD50 against hAChE, too. The hAChE inhibition by atrazine, propazine, and simazine (the most toxic pesticides) was elucidated by SB quantum mechanics (QM) DFT mechanistic and concentration-dependent kinetic studies, enriching the knowledge for design of less toxic pesticides. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
42. Effect of Storage Temperature on the Decay of Catechins and Procyanidins in Dark Chocolate.
- Author
-
PAVLOVIĆ, ALEKSANDRA N., MRMOŠANIN, JELENA M., KRSTIĆ, JOVANA N., MITIĆ, SNEŽANA S., TOŠIĆ, SNEŽANA B., MITIĆ, MILAN N., ARSIĆ, BILJANA B., and MICIĆ, RUŽICA J.
- Subjects
CATECHIN ,CHOCOLATE ,FLAVONOIDS ,PROCYANIDINS ,ARRHENIUS equation ,CHEMICAL equations - Abstract
The storage stability of catechins, procyanidins, and total flavonoids in dark chocolate was investigated. The obtained results showed that the degradation of flavonoids followed first-order reaction kinetics. Temperaturedependent degradation was modelled on the Arrhenius equation. The activation energy for the degradation of dark chocolate flavonoids during storage was 61.2 kJ/mol. During storage, flavonoids degraded more rapidly at 35°C (k = 7.8 × 10
-3 /day) than at 22°C (k = 5.4 × 10-3 /day) and 4°C (k = 2.2 × 10-3 /day). [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
43. Antimicrobial activity of human follicular fluids.
- Author
-
Stepanović, Srdjan, Djukić, Slobodanka, Veljković, Milija, Arsić, Biljana, Garalejić, Eliana, Ranin, Lazar, Stepanović, Srdjan, Djukić, Slobodanka, Veljković, Milija, Arsić, Biljana, and Garalejić, Eliana
- Subjects
LYSOZYMES ,GLYCOSIDASES ,ESTRONE ,ESTROGEN ,STREPTOCOCCUS ,ANTIBIOTICS ,ENZYME inhibitors ,HEAT ,MICROBIAL sensitivity tests ,CHEMICAL inhibitors ,PHARMACODYNAMICS - Abstract
The aim of this study was to explore the antimicrobial activity of human follicular fluid (HFF), to test the hypothesis that different strains of the same bacterial species could display different patterns of susceptibility to antimicrobial action of HFF, and to preliminarily investigate the possible mechanism of antimicrobial action of this fluid. Antimicrobial activity of 60 samples of HFF toward 30 Streptococcus agalactiae strains was determined by the agar diffusion method and broth dilution method. To explore the mechanism of antimicrobial activity, biochemical analyses were performed with selected fluid samples. The obtained results indicate that 38.3% fluid samples did not inhibit bacterial growth, 53.3% showed moderate and 8.3% high antimicrobial activity. The tested effect of HFF on S. agalactiae strains was bactericidal and was not strain dependent. Lysozyme activity was detected in HFF exhibiting antimicrobial activity. There were no statistically significant differences in concentrations of estradiol, progesterone, transferrin, iron, total protein and albumin levels among tested samples regardless of the different rate of antimicrobial activity. The obtained results indicate that lysozyme is most probably a crucial antibacterial agent in this fluid; however, some other still unidentified factors may contribute to it. [ABSTRACT FROM AUTHOR]
- Published
- 2003
- Full Text
- View/download PDF
44. Sensitivity and specificity of ultrasonography as a screening tool for gestational diabetes mellitus.
- Author
-
Perović, Milan, Garalejić, Eliana, Gojnić, Miroslava, Arsić, Biljana, Pantić, Igor, Bojović, Dragana Jovic, Fazlagić, Amira, and Gardiner, Helena
- Subjects
GESTATIONAL diabetes ,ULTRASONIC imaging ,BIOMARKERS ,PLACENTA ,HEART - Abstract
Objective: To evaluate diagnostic accuracy and efficiency of ultrasound markers of gestational diabetes (GDM) and propose an ultrasound based scoring system suitable for screening (UGDS). Methods: 110 women with singleton pregnancies and established maternal and/or pregnancy related risk factors for GDM were scanned at/or after 24 weeks gestation followed by administration of a 3 hour 100-gram oral glucose tolerance test (oGTT). A number of ultrasound markers were determined/measured, including fetal adipose subcutaneous tissue, asymmetrical macrosomy, cardiac circumference, cardiac width, and interventricular septum thickness, immature appearance of placenta, intensified breathing movements, polyhydramnios and placental thickness. Each ultrasound GDM marker was assigned one point to create the ultrasound gestational diabetes screening score (UGDS). Results: All ultrasound GDM markers were positively correlated to the disease P < 0.0001. The strongest independent predictor of GDM was an immature appearance of placenta (RR 40.1 95% CI 5.9-271.0, P < 0.0001). Receiver operator characteristics (ROC) showed an area under the curve of 95.7% confirming good ability of UGDS to discriminate between positive and negative oGTT. We propose a UGDS score of 4 providing sensitivity of 90.9%, and specificity 89.6%. Conclusions: This study suggests that UGDS is a good predictor of GDM. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
45. Phenolic Profile, Mineral Content and Antibacterial Activity of the Methanol Extract of Vaccinium myrtillus L.
- Author
-
MILJKOVIĆ, Vojkan M., NIKOLIĆ, Goran S., ZVEZDANOVIĆ, Jelena, MIHAJLOV-KRSTEV, Tatjana, ARSIĆ, Biljana B., and MILJKOVIĆ, Milena N.
- Subjects
- *
ANTIOXIDANTS , *PHYTOCHEMICALS , *ANTIBACTERIAL agents , *PHENOLS , *BILBERRY - Abstract
Bilberry is considered as one of the most economically important wild berries. However, bilberry is not enough investigated, and there are only a few published works. Therefore, we performed in one place complete qualitative analysis, antimicrobial activity against different Gram-positive and Gram-negative bacteria and contents of metals. In our research, it was found that bilberry contains different active phenolic compounds, such as chlorogenic acid, delphinidin glycoside, delphinidin arabinoside, cyanidin glycoside, cyanidin arabinoside, malvidin glycoside, peonidin glycoside, and malvidin arabinoside. The content of metals was different in leaves and fruits. In our samples, the content of aluminum, boron, barium, calcium, cadmium, chromium, copper, iron, manganese, nickel, phosphorus, silicon and zinc was higher, and contents of potassium, magnesium, and sodium were lower than in bilberry samples investigated in Latvia. Antimicrobial activity of investigated extracts was evaluated against laboratory control strains from ATCC collection, Gram (+) bacteria: Staphylococcus epidermidis ATCC 12228, Staphylococcus aureus ATCC 6538, Streptococcus pyogenes ATCC 19615, Enterococcus faecalis ATCC 19433, Propionibacterium acnae ATCC 11827, and Gram (-) bacteria: Escherichia coli ATCC 9863, Pseudomonas aeruginosa ATCC 9027, Acinetobacter boumanii ATCC 196060, Proteus mirabilis ATCC 12453, Klebsiella pneumonia ATCC 10031, and against related strains isolated from human wound swabs. V. myrtillus extract was less potent against strains from wounds compared to ATCC strains as well Gram (-) bacteria compared to Gram (+) bacteria. The most sensitive strains were St. epidermidis, St. pyogenes, P. mirabilis and S. aureus. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
46. Recent Computer-Aided Studies on Herbicides: A Short Review.
- Author
-
Milićević J, Petrović S, Tošić S, Vrecl M, and Arsić B
- Subjects
- Computer-Aided Design, Herbicides chemistry, Herbicides pharmacology
- Abstract
Current industrial herbicides have a negative impact on the environment and have widespread resistance, so computational studies on their properties, elimination, and overcoming resistance can be helpful. On the other hand, developing new herbicides, especially bioherbicides, is slow and costly. Therefore, computational studies that guide the design and search for new herbicides that exist in various plant sources, can alleviate the pain associated with the many obstacles. This review summarizes for the first time the most recent studies on both aspects of herbicides over 10 years., (© 2024 Wiley-VHCA AG, Zurich, Switzerland.)
- Published
- 2024
- Full Text
- View/download PDF
47. Hamilton anxiety scale (HAMA) in infertile women with endometriosis and its correlation with magnesium levels in peritoneal fluid.
- Author
-
Garalejić E, Bojović-Jović D, Damjanović A, Arsić B, Pantić I, Turjacanin-Pantelić D, and Perović M
- Subjects
- Adult, Anxiety diagnosis, Anxiety physiopathology, Anxiety psychology, Endometriosis psychology, Endometriosis surgery, Female, Humans, Infertility, Female psychology, Infertility, Female surgery, Laparoscopy, Prospective Studies, Serbia, Statistics as Topic, Stress, Psychological physiopathology, Stress, Psychological psychology, Ascitic Fluid metabolism, Endometriosis diagnosis, Endometriosis physiopathology, Infertility, Female diagnosis, Infertility, Female physiopathology, Magnesium metabolism, Personality Inventory statistics & numerical data, Stress, Psychological complications
- Abstract
Background: Endometriosis is a complex disease that can result in substantial morbidity, including chronic pain, dysmenorrhea and dyspareunia. There are contradictory reports regarding the connection between acute and chronic stress and magnesium levels in body fluids., Subjects and Methods: A prospective study included 87 patients undergoing laparoscopy. The study group included 40 women with endometriosis and the control group consisted of 47 women with other causes of infertility. The levels of fright were determined using HAMA scale. The measurements of Mg levels were performed using biochemical analyzer "Monarch Plus"., Results: One day before the operation, HAMA score was 9.54+/-7.34 in the women with endometriosis, and 6.69+/-5.51 in the women without endometriosis. The morning before the operation, HAMA score was 8.64 +/- 8.10 in the women with endometriosis, and 4.29+/-2.29 in the women without endometriosis. The second postoperative day, HAMA score was 8.96+/-7.60 in the women with endometriosis and 6.92+/-5.16 in the women without endometriosis. Higher HAMA score in the women with endometriosis, in comparison with the control group, in all three time periods has been found, but the differences were not statistically significant (p>0.05). A negative correlation between the concentration of Mg in peritoneal fluid and HAMA score was found in the control group (p<0.01)., Conclusions: In infertile women without endometriosis a correlation between Mg concentration in peritoneal fluid and HAMA score was found. No such correlation was found in the women with endometriosis, possibly due to a systemic disorder in endometriosis that might affect Mg transport through the cell membrane.
- Published
- 2010
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