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193 results on '"Games, D."'

1. Assessing commercialization capability of research products from inventor's view.

Author

Fithri, P., Hasan, A., Games, D., and Syafrizal, S.

Subjects
COLLEGE teachers, STRUCTURAL equation modeling, RESEARCH departments, MARKETING, INTELLECTUAL property
Abstract

The world economy is heading towards the formation of global trade which causes industry players to take innovative actions to remain competitive. One of the innovative actions that can be taken is to invest in development and research. However, not all companies have internal research departments. The solution that can be done by companies to overcome this is to establish cooperation with universities. One of the universities that is active in conducting research and development is Andalas University. Based on data from the Community Service Research Institute (LPPM), in 2020, Andalas University has obtained 235 registered patents. However, only 50 products or around 21% reached the commercialization stage and entered the industry. Based on previous research, To overcome problems in the commercialization process of research products, it is necessary to set criteria to assess the commercialization ability of research products. The criteria are technology, marketing, finance, intellectual property, human resources, government and non-financial impacts. The population in this study were Andalas University lecturers totaling 1,382 people, the number of samples in this study was 107 people. The method used in this study is the Structural Equation Modeling (SEM) method using SmartPLS3 software. The results of the study indicate that the variables of technology, marketing, finance, human resources, and intellectual property have a positive but not significant effect on the ability to commercialize research products at Andalas University. Meanwhile, non-financial and government impact variables have a positive and significant impact on the ability to commercialize research products at Andalas University. If sorted by significance then; non-financial impact, government, intellectual property, technology, human resources, marketing, and finance. With t-statistic values in order, namely 4.253, 2.274, 1.549, 0.981, 0.434, 0.155, and 0.01. [ABSTRACT FROM AUTHOR]

Published
2024
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3. A bibliometric analysis of entrepreneurship research using VOSviewer.

Author

Fithri, P., Lita, R. Prima, Games, D., Hasan, A., Maharani, D., and Kiswara, V.

Subjects
TECHNOLOGY transfer, BIBLIOMETRICS, LITERATURE reviews, ENTREPRENEURSHIP, UNIVERSITIES & colleges, SCHOLARLY periodicals
Abstract

Academic entrepreneurship is an activity that refers to researchers at universities who commercialize university research through business activities. Academic entrepreneurship can also be interpreted as a process of creating economic value through the creation, renewal, and organizational innovation that occurs inside and outside the university which results in the commercialization of research and technology transfer. The importance of academic entrepreneurship at the university level is directed to change the traditional view to a new view that sees Higher Education as an educational institution but is able to generate financial resources to cover operational costs. The purpose of this study is to analyze the extent to which academic research on entrepreneurship has been carried out. The research methodology used is literature review, by identifying entrepreneurship academic journals through the assistance of Scopus and Vosviewer. Based on the analysis, it was found that many journal publications on academic entrepreneurship were carried out in 2012. The research method used was mostly a qualitative method, with a literature review analysis. Then this type of paper is mostly in the Q1 quartile, countries that apply academic entrepreneurship a lot are the United States and England. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Abeta species removal after abeta42 immunization

Author

Nicoll JA, Barton E, Boche D, Neal JW, Ferrer I, Thompson P, Wilkinson D, Bayer A, Games D, Seubert P, Schenk D, Holmes C., VLACHOULI, CHRISTINA, Nicoll, Ja, Barton, E, Boche, D, Neal, Jw, Ferrer, I, Thompson, P, Vlachouli, Christina, Wilkinson, D, Bayer, A, Games, D, Seubert, P, Schenk, D, and Holmes, C.

Subjects
Microscopy, Confocal, Amyloid beta-Peptides, Alzheimer Vaccines, Alzheimer's disease, diagnosis/metabolism/physiopathology, Amyloid beta-Peptides, Molecular Sequence Data, Brain, Neurofibrillary Tangles, Neuropil Threads, Immunohistochemistry, Peptide Fragments, Cerebral Amyloid Angiopathy, Phagocytosis, Alzheimer Disease, diagnosis/metabolism/physiopathology, Image Processing, Computer-Assisted, Humans, Amino Acid Sequence, Microglia, Randomized Controlled Trials as Topic
Abstract

Neuropathologic examination of 3 patients with Alzheimer disease in the Elan Pharmaceuticals trial using antibodies specific for different Abeta species showed in one case, 4 months after the immunization, evidence of a stage of active plaque clearance with "moth-eaten" plaques and abundant Abeta phagocytosis by microglia. At 1 to 2 years after immunization, 2 cases showed extensive areas cleared of plaques (69% and 86% of the temporal cortex was plaque-free). Cortex cleared of plaques in all 3 cases had a characteristic constellation of features, including a very low plaque burden, sparse residual dense plaque cores, and phagocytosed Abeta within microglia. There was resolution of tau-containing dystrophic neurites, although other features of tau pathology (tangles and neuropil threads) remained and cerebral amyloid angiopathy persisted. Although most antibodies generated by Abeta42 immunization in humans bind the intact N-terminus, immunohistochemistry with specific antibodies showed clearance of all major species of Abeta (Abeta40, Abeta42, and N-terminus truncated Abeta). Abeta immunotherapy can clear all Abeta species from the cortex. However, if it is to be used for treatment of established Alzheimer disease, then the residual tau pathology and cerebral amyloid angiopathy require further study.

Published
2006

13. Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques

Author

Joachim, C., Games, D., Morris, J., Ward, P., Frenkel, D., and Selkoe, D.

Subjects
Neurons, Amyloid beta-Protein Precursor, Amyloid beta-Peptides, Staining and Labeling, Alzheimer Disease, mental disorders, Immunologic Techniques, Brain, Humans, Protein Precursors, Antibodies, Axons, Research Article
Abstract

A central unresolved issue in Alzheimer's disease is the origin of the extracellular amyloid beta protein (A beta P) found in senile plaques and its relationship to the dystrophic neurites that intimately surround it. Here the presence and distribution within senile plaques of various epitopes of the beta-amyloid precursor protein (APP) are compared with the distribution of A beta P itself and markers for plaque neurites. Several principal findings emerge: 1) antibodies to regions of APP outside of A beta P ('APP antibodies') recognize only a subgroup of senile plaques; 2) within these plaques, APP antibodies label discrete globular and granular structures morphologically resembling neurites; 3) virtually all of the plaques labeled by APP antibodies also contain neurites reactive with antibodies to tau; 4) double labeling with anti-tau and an APP antibody shows that the neuritelike profiles stained by the APP antibody are always closely associated with tau-positive neurites within the same plaque and that a minority of profiles appear to be labeled by both antibodies; and 5) antibodies to different regions throughout APP label the same profiles within plaques, suggesting the presence of the full-length precursor. The authors conclude that only a subgroup of senile plaques contain APP epitopes and that the immunostained structures are neurites. Because many A beta P-containing plaques in neocortex, cerebellum, and striatum were found to be devoid of any APP labeling, as were vascular A beta P deposits, it is unlikely that the extracellular A beta P is principally derived from the APP found within dystrophic neurites. The immunodetection of apparently full-length APP, an axonally transported protein, in selected plaque neurites provides yet another protein marker of neuritic dystrophy, possibly indicative of an aberrant regenerative response.

Published
1991

15. Apolipoprotein D mRNA expression is elevated in PDAPP transgenic mice.

Author

Thomas, E.A., Sautkulis, L.N., Criado, J.R., Games, D., and Sutcliffe, J.G.

Subjects
APOLIPOPROTEINS, ALZHEIMER'S disease, LABORATORY mice, PHYSIOLOGY
Abstract

Apolipoprotein D (apoD) expression is known to be elevated in select regions of rodent and human brain in association with different types of CNS pathology. To investigate a potential role for apoD in the neuropathology of Alzheimer's disease, we have measured apoD mRNA expression in transgenic mice expressing mutated human amyloid precursor protein under control of platelet-derived growth factor promoter (PDAPP mice). In situ hybridization analysis revealed increased apoD mRNA expression in brains of aged (26 months) PDAPP transgenic mice compared to aged littermate controls. These increases were most prominent in the hippocampal fimbria, corpus callosum and other white matter tracts. No substantial increases in expression were observed in white matter regions in young (6 months) PDAPP transgenic mice compared to young controls. Comparison between aged and young control mice revealed increased apoD expression in similar white matter regions of the aged animals. These findings suggest that, although increases in apoD expression are a normal feature of brain aging, super-increases may represent a glial cell compensatory response to beta-amyloid deposition in Alzheimer's disease. [ABSTRACT FROM AUTHOR]

Published
2001
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16. INDUSTRIAL SCALE-UP OF COUNTERCURRENT CHROMATOGRAPHY.

Author

Sutherland, I.A., Booth, A.J., Brown, L., Kemp, B., Kidwell, H., Games, D., Graham, A.S., Guillon, G.G., Hawes, D., Hayes, M., Janaway, L., Lye, G.J., Massey, P., Preston, C., Shering, P., Shoulder, T., Strawson, C., and Wood, P.

Subjects
HYDRODYNAMICS, MANUFACTURING processes, BIOCHEMICAL engineering, COUNTERCURRENT chromatography
Abstract

The hydrodynamic, engineering, and chromatographic variables affecting scale-up of countercurrent chromatography (CCC) are examined. The predictable and linear scale-up from the current laboratory scale technology to industrial process scale, capable of kgm/month in the first phase, is demonstrated. Continued research will prepare the way for a new generation of tonne/annum capacity high throughput, high resolution CCC machines for pilot and plant scale separations of a range of bioprocess products. [ABSTRACT FROM AUTHOR]

Published
2001
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41. Book reviews.

Author

Murray, Ian, Berridge, John C., Littlejohn, David, Watson, Colin, Fearson, Martin, Games, D. E., Connolly, J. D., Everatt, Brian, and Vadgama, P.

Published
1994
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42. Analysis of carotenoids by field desorption mass spectrometry.

Author

Watts, C. D., Maxwell, J. R., Games, D. E., and Rossiter, M.

Abstract

The mass spectra of a variety of authentic carotenoids covering a range of structural types have been studied using the field desorption technique. All the compounds examined show the molecular ion as the base peak, even where this ion is of very low intensity in the electron-impact spectra. Little fragmentation is observed, but thermal decomposition can be induced in certain cases by using higher emitter currents. Application to a simple mixture of authentic compounds and a more complex mixture of sedimentary origin shows the potential of the method in the rapid qualitative screening of carotenoids in crude extracts. [ABSTRACT FROM AUTHOR]

Published
1975
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44. Spectrochemical detectors in chromatography.

Author

Gaskell, Simon J., Games, D. E., Brinkman, U. A. Th., Frei, R. W., Fell, Anthony F., Schill, Göran, Gelpí, E., Traveset, J., Such, V., Gonzalo, R., Sternson, L. A., Marsh, K. C., Bannister, S. J., and Repta, A. J.

Published
1983
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