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381 results on '"Huang, Yiwei"'

38. The associations between dysregulation of human blood metabolites and lung cancer risk: evidence from genetic data.

Author

Wu, Gujie, Liu, Jun, Shi, Haochun, Pan, Binyang, Li, Min, Wang, Xiaolin, Li, Yao, Cheng, Lin, Guo, Weigang, and Huang, Yiwei

Subjects
SMALL cell lung cancer, GENOME-wide association studies, SQUAMOUS cell carcinoma, LUNG cancer, DISEASE risk factors
Abstract

Background: Metabolic dysregulation is recognized as a significant hallmark of cancer progression. Although numerous studies have linked specific metabolic pathways to cancer incidence, the causal relationship between blood metabolites and lung cancer risk remains unclear. Methods: Genomic data from 29,266 lung cancer patients and 56,450 control individuals from the Transdisciplinary Research in Cancer of the Lung and the International Lung Cancer Consortium (TRICL-ILCCO) were utilized, and findings were replicated using additional data from the FinnGen consortium. The analysis focused on the associations between 486 blood metabolites and the susceptibility to overall lung cancer and its three major clinical subtypes. Various Mendelian randomization methods, including inverse-variance weighting, weighted median estimation, and MR-Egger regression, were employed to ensure the robustness of our findings. Results: A total of 19 blood metabolites were identified with significant associations with lung cancer risk. Specifically, oleate (OR per SD = 2.56, 95% CI: 1.51 to 4.36), 1-arachidonoylglyceropholine (OR = 1.79, 95% CI: 1.22 to 2.65), and arachidonate (OR = 1.67, 95% CI: 1.16 to 2.40) were associated with a higher risk of lung cancer. Conversely, 1-linoleoylglycerophosphoethanolamine (OR = 0.57, 95% CI: 0.40 to 0.82), ADpSGEGDFXAEGGGVR, a fibrinogen cleavage peptide (OR = 0.60, 95% CI: 0.47 to 0.77), and isovalerylcarnitine (OR = 0.62, 95% CI: 0.49 to 0.78) were associated with a lower risk of lung cancer. Notably, isoleucine (OR = 9.64, 95% CI: 2.55 to 36.38) was associated with a significantly higher risk of lung squamous cell cancer, while acetyl phosphate (OR = 0.11, 95% CI: 0.01 to 0.89) was associated with a significantly lower risk of small cell lung cancer. Conclusion: This study reveals the complex relationships between specific blood metabolites and lung cancer risk, highlighting their potential as biomarkers for lung cancer prevention, screening, and treatment. The findings not only deepen our understanding of the metabolic mechanisms of lung cancer but also provide new insights for future treatment strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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43. Separation of ReO4−/TcO4− from simulated radioactive waste liquid by a novel series of anion exchange resins.

Author

Huang, Yiwei, Chen, Xinlong, Shen, Yinglin, Li, Xiaomin, Zhi, Xupeng, Liu, Peng, Liu, Meiying, and Liu, Bin

Subjects
RADIOACTIVE wastes, ION exchange resins, LIQUID waste, FOURIER transform infrared spectroscopy, ENERGY dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy
Abstract

Selective removal of 99TcO₄− from radioactive wastewater is a challenging but significant task, which benefits spent fuel reprocessing and radioactive-waste leakage treatment. This work introduces the performance of adsorption ReO4− using a series of novel anion exchange resins, namely MAPE-1, MAPE-2, MAPE-3, and MAGD-1, impregnated with functionalized ionic liquids as active sites. They exhibit a high selectivity towards TcO₄−/ReO₄−, in a wide pH range of pH 5–11 for ReO₄−/TcO₄− adsorption. Among these resins, MAPE-1 has the best adsorption performance for ReO4−, with a maximum adsorption capacity of 202.4 mg/g and a high distribution ratio Kd of 6.2 × 10⁶ mL/g at pH 7. The adsorption mechanism involves anion exchange between functionalized ionic liquids and TcO₄−/ReO₄−, which is supported by X-ray energy dispersive spectroscopy (EDS) and Fourier Transform Infrared spectroscopy (FT-IR) analyses. In addition, X-ray photoelectron spectroscopy (XPS) further illustrates the interaction between the resin and perrhenate. [ABSTRACT FROM AUTHOR]

Published
2024
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