20 results on '"Kameda, Takuya"'
Search Results
2. Restoration of Elbow Flexion with a Pedicled Latissimus Dorsi Myocutaneous Flap to a Brachial Plexus Injury at the Terminal Nerve Level
- Author
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Kameda, Takuya, Soichi, Ejiri, Yokota, Takeru, and Konno, Shin-ichi
- Published
- 2019
- Full Text
- View/download PDF
3. Temporal and Spatial Changes of μ-Opioid Receptors in the Brain, Spinal Cord and Dorsal Root Ganglion in a Rat Lumbar Disc Herniation Model
- Author
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Kaneuchi, Yoichi, Sekiguchi, Miho, Kameda, Takuya, Kobayashi, Yoshihiro, and Konno, Shinichi
- Published
- 2018
- Full Text
- View/download PDF
4. Brain Metabolite Changes in the Anterior Cingulate Cortex of Chronic Low Back Pain Patients and Correlations Between Metabolites and Psychological State
- Author
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Kameda, Takuya, Fukui, Sei, Tominaga, Ryoji, Sekiguchi, Miho, Iwashita, Narihito, Ito, Kazuki, Tanaka-Mizuno, Sachiko, and Konno, Shin-ichi
- Published
- 2018
- Full Text
- View/download PDF
5. Investigation of the Effect of Diabetes on Radiculopathy Induced by Nucleus Pulposus Application to the DRG in a Spontaneously Diabetic Rat Model
- Author
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Kameda, Takuya, Sekiguchi, Miho, Kaneuchi, Yoichi, and Konno, Shin-ichi
- Published
- 2017
- Full Text
- View/download PDF
6. Walking ability after resection of soft tissue sarcoma of the thigh and the sciatic nerve.
- Author
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Isobe, Mizuki, Hakozaki, Michiyuki, Kaneuchi, Yoichi, Ogawa, Itaru, Suzuki, Takeo, Sasaki, Nobuyuki, Kameda, Takuya, and Matsumoto, Yoshihiro
- Subjects
SCIATIC nerve ,SARCOMA ,SURGICAL margin ,THIGH - Abstract
Key Clinical Message: Walking ability may be fairly well maintained after sciatic nerve resection combined with wide resection of soft tissue sarcoma, therefore, surgeons should not hesitate to perform sciatic nerve resection to achieve an adequate surgical margin. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
7. Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling
- Author
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Kameda, Takuya, Zvick, Joel, Vuk, Miriam, Sadowska, Aleksandra, Tam, Wai Kit, Leung, Victor Y., Bölcskei, Kata, Helyes, Zsuzsanna, Applegate, Lee Ann, Hausmann, Oliver N., Klasen, Juergen, Krupkova, Olga, and Wuertz-Kozak, Karin
- Subjects
musculoskeletal diseases ,collagen ,Nucleus Pulposus ,TRPV Cation Channels ,low back pain ,TRP channels ,pro-inflammatory cytokines ,aggrecanases ,TRPA1 ,TRPV1 ,TRPV2 ,TRPV4 ,TRPC6 ,Intervertebral Disc Degeneration ,Article ,lcsh:Chemistry ,Mice ,Animals ,Humans ,Calcium Signaling ,Intervertebral Disc ,TRPA1 Cation Channel ,lcsh:QH301-705.5 ,Physical and Theoretical Chemistry ,Inorganic Chemistry ,Organic Chemistry ,Spectroscopy ,Molecular Biology ,Catalysis ,General Medicine ,Computer Science Applications ,Inflammation ,Mice, Knockout ,musculoskeletal system ,Extracellular Matrix ,Gene Expression Regulation ,lcsh:Biology (General) ,lcsh:QD1-999 ,Inflammation Mediators ,psychological phenomena and processes - Abstract
Transient receptor potential (TRP) channels have emerged as potential sensors and transducers of inflammatory pain. The aims of this study were to investigate (1) the expression of TRP channels in intervertebral disc (IVD) cells in normal and inflammatory conditions and (2) the function of Transient receptor potential ankyrin 1 (TRPA1) and Transient receptor potential vanilloid 1 (TRPV1) in IVD inflammation and matrix homeostasis. RT-qPCR was used to analyze human fetal, healthy, and degenerated IVD tissues for the gene expression of TRPA1 and TRPV1. The primary IVD cell cultures were stimulated with either interleukin-1 beta (IL-1&beta, ) or tumor necrosis factor alpha (TNF-&alpha, ) alone or in combination with TRPA1/V1 agonist allyl isothiocyanate (AITC, 3 and 10 µ, M), followed by analysis of calcium flux and the expression of inflammation mediators (RT-qPCR/ELISA) and matrix constituents (RT-qPCR). The matrix structure and composition in caudal motion segments from TRPA1 and TRPV1 wild-type (WT) and knock-out (KO) mice was visualized by FAST staining. Gene expression of other TRP channels (A1, C1, C3, C6, V1, V2, V4, V6, M2, M7, M8) was also tested in cytokine-treated cells. TRPA1 was expressed in fetal IVD cells, 20% of degenerated IVDs, but not in healthy mature IVDs. TRPA1 expression was not detectable in untreated cells and it increased upon cytokine treatment, while TRPV1 was expressed and concomitantly reduced. In inflamed IVD cells, 10 µ, M AITC activated calcium flux, induced gene expression of IL-8, and reduced disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) and collagen 1A1, possibly via upregulated TRPA1. TRPA1 KO in mice was associated with signs of degeneration in the nucleus pulposus and the vertebral growth plate, whereas TRPV1 KO did not show profound changes. Cytokine treatment also affected the gene expression of TRPV2 (increase), TRPV4 (increase), and TRPC6 (decrease). TRPA1 might be expressed in developing IVD, downregulated during its maturation, and upregulated again in degenerative disc disease, participating in matrix homeostasis. However, follow-up studies with larger sample sizes are needed to fully elucidate the role of TRPA1 and other TRP channels in degenerative disc disease.
- Published
- 2019
- Full Text
- View/download PDF
8. Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc
- Author
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Kameda, Takuya, Zvick, Joel, Vuk, Miriam, Sadowska, Aleksandra, Tam, Wai Kit, Leung, Victor Y., Bölcskei, Kata, Helyes, Zsuzsanna, Applegate, Lee Ann, Hausmann, Oliver N., Klasen, Juergen, Krupkova, Olga, and Würtz-Kozak, Karin (Dr.)
- Subjects
Department Sport- und Gesundheitswissenschaften ,ddc:610 ,psychological phenomena and processes - Abstract
Transient receptor potential (TRP) channels have emerged as potential sensors and transducers of inflammatory pain. The aims of this study were to investigate (1) the expression of TRP channels in intervertebral disc (IVD) cells in normal and inflammatory conditions and (2) the function of Transient receptor potential ankyrin 1 (TRPA1) and Transient receptor potential vanilloid 1 (TRPV1) in IVD inflammation and matrix homeostasis. RT-qPCR was used to analyze human fetal, healthy, and degenerated IVD tissues for the gene expression of TRPA1 and TRPV1. The primary IVD cell cultures were stimulated with either interleukin-1 beta (IL-1) or tumor necrosis factor alpha (TNF-) alone or in combination with TRPA1/V1 agonist allyl isothiocyanate (AITC, 3 and 10 mu M), followed by analysis of calcium flux and the expression of inflammation mediators (RT-qPCR/ELISA) and matrix constituents (RT-qPCR). The matrix structure and composition in caudal motion segments from TRPA1 and TRPV1 wild-type (WT) and knock-out (KO) mice was visualized by FAST staining. Gene expression of other TRP channels (A1, C1, C3, C6, V1, V2, V4, V6, M2, M7, M8) was also tested in cytokine-treated cells. TRPA1 was expressed in fetal IVD cells, 20% of degenerated IVDs, but not in healthy mature IVDs. TRPA1 expression was not detectable in untreated cells and it increased upon cytokine treatment, while TRPV1 was expressed and concomitantly reduced. In inflamed IVD cells, 10 mu M AITC activated calcium flux, induced gene expression of IL-8, and reduced disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) and collagen 1A1, possibly via upregulated TRPA1. TRPA1 KO in mice was associated with signs of degeneration in the nucleus pulposus and the vertebral growth plate, whereas TRPV1 KO did not show profound changes. Cytokine treatment also affected the gene expression of TRPV2 (increase), TRPV4 (increase), and TRPC6 (decrease). TRPA1 might be expressed in developing IVD, downregulated during its maturation, and upregulated again in degenerative disc disease, participating in matrix homeostasis. However, follow-up studies with larger sample sizes are needed to fully elucidate the role of TRPA1 and other TRP channels in degenerative disc disease.
- Published
- 2019
9. Osmosensing, osmosignalling and inflammation
- Author
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Sadowska, Aleksandra, Kameda, Takuya, Krupkova, Olga, and Würtz-Kozak, Karin
- Subjects
ddc:540 ,Department Sport- und Gesundheitswissenschaften ,ddc:610 - Abstract
Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD's extracellular matrix causes osmotic imbalance, which, together with an altered function of cellular receptors and signalling pathways, instigates local osmotic stress. Cellular responses to osmotic stress include osmoadaptation and activation of pro-inflammatory pathways. This review summarises the current knowledge on how IVD cells sense local osmotic changes and translate these signals into physiological or pathophysiological responses, with a focus on inflammation. Furthermore, it discusses the expression and function of putative membrane osmosensors (e.g. solute carrier transporters, transient receptor potential channels, aquaporins and acid-sensing ion channels) and osmosignalling mediators [e.g. tonicity responseelement-binding protein/nuclear factor of activated T-cells 5 (TonEBP/NFAT5), nuclear factor kappa-lightchain-enhancer of activated B cells (NF-kappa B)] in healthy and degenerated IVDs. Finally, an overview of the potential therapeutic targets for modifying osmosensing and osmosignalling in degenerated IVDs is provided.
- Published
- 2018
10. Osmosensing, osmosignalling and inflammation: how intervertebral disc cells respond to altered osmolarity
- Author
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Sadowska, Aleksandra, Kameda, Takuya, Krupkova, Olga, and Würtz-Kozak, Karin
- Subjects
lcsh:Diseases of the musculoskeletal system ,transient receptor potential channel ,lcsh:Surgery ,osmotic ,IVD ,inflammatory ,lcsh:RD1-811 ,degenerative disc disease ,Intervertebral disc degeneration ,osmolarity ,Transient receptor potential channels (TRP) ,tonicity-responsive enhancer binding protein ,aquaporin ,540 Chemie und zugeordnete Wissenschaften ,hyper-osmolarity ,lcsh:RC925-935 ,610 Medizin und Gesundheit ,hypo-osmolarity - Abstract
Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD’s extracellular matrix causes osmotic imbalance, which, together with an altered function of cellular receptors and signalling pathways, instigates local osmotic stress. Cellular responses to osmotic stress include osmoadaptation and activation of pro-inflammatory pathways. This review summarises the current knowledge on how IVD cells sense local osmotic changes and translate these signals into physiological or pathophysiological responses, with a focus on inflammation. Furthermore, it discusses the expression and function of putative membrane osmosensors (e.g. solute carrier transporters, transient receptor potential channels, aquaporins and acid-sensing ion channels) and osmosignalling mediators [e.g. tonicity response-element-binding protein/nuclear factor of activated T-cells 5 (TonEBP/NFAT5), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)] in healthy and degenerated IVDs. Finally, an overview of the potential therapeutic targets for modifying osmosensing and osmosignalling in degenerated IVDs is provided., European Cells & Materials, 36, ISSN:1473-2262
- Published
- 2018
11. p38 MAPK Facilitates Crosstalk Between Endoplasmic Reticulum Stress and IL-6 Release in the Intervertebral Disc
- Author
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Krupkova, Olga, Sadowska, Aleksandra, Kameda, Takuya, Hitzl, Wolfgang, Hausmann, Oliver Nic, Klasen, Juergen, and Wuertz-Kozak, Karin
- Subjects
GRP78 ,IL-6 ,inflammation ,endoplasmic reticulum stress ,Department Sport- und Gesundheitswissenschaften ,intervertebral disc ,GADD153 ,ddc:610 ,p38 MAPK ,CHOP ,610 Medizin und Gesundheit ,Strukturbereich Kognitionswissenschaften - Abstract
Degenerative disc disease is associated with increased expression of pro-inflammatory cytokines in the intervertebral disc (IVD). However, it is not completely clear how inflammation arises in the IVD and which cellular compartments are involved in this process. Recently, the endoplasmic reticulum (ER) has emerged as a possible modulator of inflammation in age-related disorders. In addition, ER stress has been associated with the microenvironment of degenerated IVDs. Therefore, the aim of this study was to analyze the effects of ER stress on inflammatory responses in degenerated human IVDs and associated molecular mechanisms. Gene expression of ER stress marker GRP78 and pro-inflammatory cytokines IL-6, IL-8, IL-1β, and TNF-α was analyzed in human surgical IVD samples (n = 51, Pfirrmann grade 2–5). The expression of GRP78 positively correlated with the degeneration grade in lumbar IVDs and IL-6, but not with IL-1β and TNF-α. Another set of human surgical IVD samples (n = 25) was used to prepare primary cell cultures. ER stress inducer thapsigargin (Tg, 100 and 500 nM) activated gene and protein expression of IL-6 and induced phosphorylation of p38 MAPK. Both inhibition of p38 MAPK by SB203580 (10 µM) and knockdown of ER stress effector CCAAT-enhancer-binding protein homologous protein (CHOP) reduced gene and protein expression of IL-6 in Tg-treated cells. Furthermore, the effects of an inflammatory microenvironment on ER stress were tested. TNF-α (5 and 10 ng/mL) did not activate ER stress, while IL-1β (5 and 10 ng/mL) activated gene and protein expression of GRP78, but did not influence [Ca2+]i flux and expression of CHOP, indicating that pro-inflammatory cytokines alone may not induce ER stress in vivo. This study showed that IL-6 release in the IVD can be initiated following ER stress and that ER stress mediates IL-6 release through p38 MAPK and CHOP. Therapeutic targeting of ER stress response may reduce the consequences of the harsh microenvironment in degenerated IVD., Frontiers in Immunology, 9, ISSN:1664-3224
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- 2018
- Full Text
- View/download PDF
12. Temporal and Spatial Changes of μ-Opioid Receptors in the Brain, Spinal Cord and Dorsal Root Ganglion in a Rat Lumbar Disc Herniation Model.
- Author
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Kaneuchi, Yoichi, Sekiguchi, Miho, Kameda, Takuya, Kobayashi, Yoshihiro, and Konno, Shin-ichi
- Published
- 2019
- Full Text
- View/download PDF
13. Antibacterial effects of nano-imprinted moth-eye film in practical settings.
- Author
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Yamada, Miho, Minoura, Kiyoshi, Mizoguchi, Takashi, Nakamatsu, Kenichiro, Taguchi, Tokio, Kameda, Takuya, Sekiguchi, Miho, Suzutani, Tatsuo, and Konno, Shinichi
- Subjects
POLYETHYLENE terephthalate ,ANTIBACTERIAL agents ,NANOFABRICATION ,HYDROPHILIC interactions ,PHTHALATE esters ,THERMOPLASTICS - Abstract
Background: Recent studies report that surfaces displaying micrometer- or nanometer-sized undulating structures exhibit antibacterial effects. In previous work, we described the use of an advanced nanofabrication technique to generate an artificial biomimetic Moth-eye film by coating a polyethylene terephthalate (PET) film with nanoscale moth-eye protrusions made from a hydrophilic resin. This moth-eye film exhibited enhanced antibacterial effects in in vitro experiments. The aim of the present study was to verify the antibacterial efficacy of the Moth-eye film in practical environments. Materials and methods: The antibacterial effects of three types of film (Moth-eye film, Flat film, and PET film) were compared. Sample films were pasted onto hand washing basins at the testing locations. After several hours, bacteria were collected from the surface of the sample films with one of three kinds of culture media stamper (to permit identification of bacterial species). The stampers were incubated for 48 hours at 35°C, and the numbers of colonies were counted. Results and discussion: The number of common bacteria including E. coli and S. aureus obtained from the Moth-eye film was significantly lower than those from the PET film (p<0.05) and Flat film at 1 hour (p<0.05). This study found that the Moth-eye film showed a long-term (6h) antibacterial effect and the Moth-eye structure (PET coated with nanoscale cone-shaped pillars) demonstrated a physical antibacterial effect from earlier time points. Therefore, the Moth-eye film appears to have potential general-purpose applications in practical environments. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
14. Brain Metabolite Changes in the Anterior Cingulate Cortex of Chronic Low Back Pain Patients and Correlations Between Metabolites and Psychological State.
- Author
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Takuya Kameda, Sei Fukui, Ryoji Tominaga, Miho Sekiguchi, Narihito Iwashita, Kazuki Ito, Sachiko Tanaka-Mizuno, Shin-ichi Konno, Kameda, Takuya, Fukui, Sei, Tominaga, Ryoji, Sekiguchi, Miho, Iwashita, Narihito, Ito, Kazuki, Tanaka-Mizuno, Sachiko, and Konno, Shin-Ichi
- Published
- 2018
- Full Text
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15. Investigation of the Effect of Diabetes on Radiculopathy Induced by Nucleus Pulposus Application to the DRG in a Spontaneously Diabetic Rat Model.
- Author
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Takuya Kameda, Miho Sekiguchi, Yoichi Kaneuchi, Shin-ichi Konno, Kameda, Takuya, Sekiguchi, Miho, Kaneuchi, Yoichi, and Konno, Shin-Ichi
- Published
- 2017
- Full Text
- View/download PDF
16. Measurement of mechanical withdrawal thresholds and gait analysis using the CatWalk method in a nucleus pulposus-applied rodent model.
- Author
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Kameda, Takuya, Kaneuchi, Yoichi, Sekiguchi, Miho, and Konno, Shin-ichi
- Subjects
DORSAL root ganglia ,BIOMECHANICS ,NUCLEUS pulposus ,LABORATORY rodents ,ANIMAL locomotion - Abstract
Background: There are some previous reports of gait analysis using a rodent pain model. Applying the CatWalk method, objective measurements of pain-related behavior could be evaluated, but this method has not been investigated using the nucleus pulposus (NP) applied model, which was developed as a model of lumber disc herniation. We aimed to measure mechanical withdrawal thresholds and analyze gait patterns using the CatWalk method for the evaluation of the pain-related behavior caused by NP application. Methods: Twenty-four nine-week-old female Sprague-Dawley rats were randomly divided into two experimental groups, the NP group ( n = 12), in which autologous NP from the tail was applied to the left L5 dorsal root ganglion, and the sham-operated group ( n = 12). Measurements of mechanical withdrawal thresholds were performed using von Frey filaments touching the left footpads, and gait analysis was performed using the CatWalk method. These experiments were conducted 1 day before surgery and 7, 14, 21, and 28 days after surgery. Data were statistically analyzed using the Wilcoxon rank-sum test. Results: The NP group showed significantly lower withdrawal thresholds than the sham group at days 14 and 21. Stand (duration of contact of a paw with the glass plate) was significantly higher in the NP group at days 7 and 14, whereas step cycle (duration between two consecutive initial contacts of the same paw) and duty cycle ( stand as a percentage of step cycle) were the same at day 7. Long initial dual stance (duration of ground contact for both hind paws simultaneously, but the first one in a step cycle of a target hind paw) of the right hind paw was measured at days 7 and 14. The left hind paw per right hind paw ratio of the stand index (speed at which the paw loses contact with the glass plate) and mean intensity (mean intensity of the complete paw) changed at day 7 or 14. Phase dispersion (parameter describing the temporal relationship between placement of two paws) of the hind paws decreased at day 7. Conclusions: Rats with applied NP showed a decreased withdrawal threshold and abnormal gait. The differences in gait parameters between the NP and sham groups were observed at an earlier time point than the withdrawal thresholds. Gait analysis could be an effective method for understanding pain caused by applied NP. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
17. Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling.
- Author
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Zvick, Joel, Vuk, Miriam, Sadowska, Aleksandra, Krupkova, Olga, Kameda, Takuya, Wuertz-Kozak, Karin, Tam, Wai Kit, Leung, Victor Y., Bölcskei, Kata, Helyes, Zsuzsanna, Applegate, Lee Ann, Hausmann, Oliver N., and Klasen, Juergen
- Subjects
LUMBAR pain ,TRP channels ,CYTOKINES ,COLLAGEN ,INFLAMMATION - Abstract
Transient receptor potential (TRP) channels have emerged as potential sensors and transducers of inflammatory pain. The aims of this study were to investigate (1) the expression of TRP channels in intervertebral disc (IVD) cells in normal and inflammatory conditions and (2) the function of Transient receptor potential ankyrin 1 (TRPA1) and Transient receptor potential vanilloid 1 (TRPV1) in IVD inflammation and matrix homeostasis. RT-qPCR was used to analyze human fetal, healthy, and degenerated IVD tissues for the gene expression of TRPA1 and TRPV1. The primary IVD cell cultures were stimulated with either interleukin-1 beta (IL-1β) or tumor necrosis factor alpha (TNF-α) alone or in combination with TRPA1/V1 agonist allyl isothiocyanate (AITC, 3 and 10 µM), followed by analysis of calcium flux and the expression of inflammation mediators (RT-qPCR/ELISA) and matrix constituents (RT-qPCR). The matrix structure and composition in caudal motion segments from TRPA1 and TRPV1 wild-type (WT) and knock-out (KO) mice was visualized by FAST staining. Gene expression of other TRP channels (A1, C1, C3, C6, V1, V2, V4, V6, M2, M7, M8) was also tested in cytokine-treated cells. TRPA1 was expressed in fetal IVD cells, 20% of degenerated IVDs, but not in healthy mature IVDs. TRPA1 expression was not detectable in untreated cells and it increased upon cytokine treatment, while TRPV1 was expressed and concomitantly reduced. In inflamed IVD cells, 10 µM AITC activated calcium flux, induced gene expression of IL-8, and reduced disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) and collagen 1A1, possibly via upregulated TRPA1. TRPA1 KO in mice was associated with signs of degeneration in the nucleus pulposus and the vertebral growth plate, whereas TRPV1 KO did not show profound changes. Cytokine treatment also affected the gene expression of TRPV2 (increase), TRPV4 (increase), and TRPC6 (decrease). TRPA1 might be expressed in developing IVD, downregulated during its maturation, and upregulated again in degenerative disc disease, participating in matrix homeostasis. However, follow-up studies with larger sample sizes are needed to fully elucidate the role of TRPA1 and other TRP channels in degenerative disc disease. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
18. Foot Tapping Test as a Simple Quantitative Index of Motor Function for Lumbosacral Radiculopathy.
- Author
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Kobayashi H, Nikaido T, Otani K, Watanabe K, Kato K, Kobayashi Y, Hakozaki M, Kameda T, Kaneuchi Y, Sekiguchi M, Yabuki S, Konno SI, and Matsumoto Y
- Abstract
Study Design: We conducted a retrospective review of data from patients who underwent surgical treatment for lumbosacral radiculopathy., Objective: To assess the effectiveness of the foot tapping test (FTT) in evaluating lower limb motor function in patients with lumbosacral radiculopathy pre- and post-surgery., Summary of Background Data: Lumbosacral radiculopathy is becoming increasingly common in aging populations. Despite standard treatments, paralysis often leads to incomplete postoperative recovery, necessitating early detection and interventions., Methods: We enrolled individuals who underwent surgery for lumbosacral radiculopathy at our facility between 2009 and 2020. Patients with a history of lumbar surgeries, dialysis, rheumatoid arthritis, and transitional vertebrae were excluded. The FTT score was measured by having the sole of the foot tap as many times as possible for 10 s while keeping the heel in contact with the floor. The L4, L5, and S1 groups were assigned using the scores on the side of the radiculopathy, and the control group was assigned using the scores on the intact side. Data were analyzed using Dunnett's test for group comparisons and paired t-tests for pre-post-surgery comparisons., Results: Of the 522 eligible patients, 80 (159 nerve roots, one patient with hemi-prosthetic leg) were analyzed. The preoperative FTT scores in the L4 and L5 groups were significantly lower than those in the control group, indicating functional impairment. One year post-surgery, all groups showed improvements in FTT scores, with the L5 group exhibiting significant improvements compared to the control; this was supported by the results of sensitivity analyses considering the effects of paralysis and pain., Conclusion: The FTT is a valuable tool for the early detection of lower limb motor dysfunction in lumbosacral radiculopathy, particularly for L5 nerve root impairment, where it aids in timely surgical intervention and may improve postoperative outcomes and quality of life., Competing Interests: Conflict of Interest and Source of Funding: The authors have no relevant financial relationships to disclose., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2024
- Full Text
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19. Forearm compartment syndrome due to acquired hemophilia that required massive blood transfusions after fasciotomy: A case report.
- Author
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Kameda T, Yokota T, Ejiri S, and Konno SI
- Abstract
Background: Acquired hemophilia is rare. In some cases, the bleeding in muscle causes compartment syndrome. However, it is not clear whether fasciotomy should be performed for the compartment syndrome caused by acquired hemophilia because of the risk of bleeding and the unknown functional results., Case Summary: A 75-year-old woman was admitted with severe pain of the right forearm with no preceding traumatic event. The right forearm was obviously swollen, and stretch pain was observed. Subcutaneous hematomas were suspected in various parts of the body. Compartment pressure was 110 mmHg on the volar side. Activated partial thromboplastin time (aPTT) was prolonged to 54.9 s. Fasciotomy was performed, and hematoma was observed in the volar compartment. Postoperative laboratory examinations revealed a low level of factor VIII (FVIII) activity (12.5%) and a high level of FVIII inhibitor (15.2 bethesda units/mL). Acquired hemophilia A was diagnosed. Though recombinant clotting factors were administered, transfusion of red blood cells reached 46 units (140 mL/unit). Hemostasis was achieved 9 d after fasciotomy. The total cost of the clotting factor concentrates administered reached 28834600 yen. With prednisolone, FVIII activity and aPTT recovered gradually. Final function of the hand was good in the index finger and excellent in the others., Conclusion: Fasciotomy resulted in good function of the hand in a case of non-traumatic compartment syndrome caused by acquired hemophilia, but life-threatening bleeding occurred, and the cost of clotting factor treatment was high. Preparation of sufficient blood transfusion, preoperative administration of recombinant activated clotting factor VII, and prompt fasciotomy could be ideal for such cases., Competing Interests: Conflict-of-interest statement: All authors do not have any conflict of interest., (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
20. Beauty parlor stroke syndrome due to a bone fragment from an osteophyte of the atlas: case report.
- Author
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Kameda T, Otani K, Tamura T, and Konno S
- Subjects
- Beauty, Cerebral Angiography methods, Decompression, Surgical, Humans, Male, Middle Aged, Neck surgery, Osteophyte diagnosis, Vertebral Artery surgery, Vertebrobasilar Insufficiency diagnosis, Vertebrobasilar Insufficiency surgery, Bone and Bones surgery, Cervical Atlas surgery, Osteophyte surgery, Stroke surgery
- Abstract
Beauty parlor stroke syndrome (BPSS) is a rare condition characterized by mechanical impingement of a vertebral artery (VA) during neck rotation and/or hyperextension followed by vertebrobasilar insufficiency. However, there have been no reports of BPSS in which the cause of mechanical impingement was identified and no cases for which surgical treatment was reported. The authors report the case of a 56-year-old Japanese man who presented with presyncope that occurred during cervical extension. Given the possibility of vertebrobasilar insufficiency, digital subtraction angiography and CT angiography were performed. These studies revealed that the right VA was hypoplastic and the left VA was dominant. Moreover, in the position of cervical extension, the dominant left VA showed constriction caused by a bone fragment of an osteophyte of the atlas. Removal of the bone fragment was performed. Postoperative left vertebral angiography showed improvement of blood flow in the extended position, and the presyncope completely disappeared. The pathomechanism of this case was a bone fragment compressing the left VA in the C-1 groove during neck extension. In BPSS patients with recurrent transient symptoms, the possibility of this mechanism of VA constriction by a free bone fragment should be considered.
- Published
- 2018
- Full Text
- View/download PDF
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