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3. New Insights Into Accelerometer-Measured Habitual Physical Activity and Sedentary Time During Early Recovery in Pediatric Concussion.

Author

Sharma, Bhanu, Obeid, Joyce, DeMatteo, Carol, Noseworthy, Michael D., and Timmons, Brian W.

Subjects
SECONDARY analysis, RESEARCH funding, ACCELEROMETRY, SEDENTARY lifestyles, SEX distribution, CONVALESCENCE, PHYSICAL activity, BRAIN concussion, CHILDREN
Abstract

Purpose: Concussion management is shifting away from a rest-is-best approach, as data now suggest that exercise-is-medicine for this mild brain injury. Despite this, we have limited data on habitual physical activity following concussion. Therefore, our objective was to quantify accelerometer-measured physical activity and sedentary time in children with concussion (within the first month of injury) and healthy controls. We hypothesized that children with concussion would be less active than their healthy peers. Methods: We performed a secondary analysis of prospectively collected accelerometer data. Our sample included children with concussion (n = 60, 31 females) and historical controls (n = 60) matched for age, sex, and season of accelerometer wear. Results: Children with concussion were significantly more sedentary than controls (mean difference [MD], 38.3 min/d, P =.006), and spent less time performing light physical activity (MD, −19.5 min/d, P =.008), moderate physical activity (MD, −9.8 min/d, P <.001), and vigorous physical activity (MD, −12.0 min/d, P <.001); these differences were observed from 8:00 AM to 9:00 PM. Sex-specific analyses identified that girls with concussion were less active and more sedentary than both boys with concussion (P =.010) and healthy girls (P <.010). Conclusion: There is an activity deficit observed within the first month of pediatric concussion. Physical activity guidelines should address this while considering sex effects. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Kang, Min Su, Adamo, Sabrina, Scott, Christopher, Ramirez, Joel, Swardfager, Walter, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert Jr, Noseworthy, Michael D, Prato, Frank S, Sahlas, Demetrios J, Smith, Eric E, Kuo, Phillip H, Chad, Jordan A, Pasternak, Ofer, Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E, and Goubran, Maged

Published
2023
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10. Lower brown adipose tissue activity is associated with non-alcoholic fatty liver disease but not changes in the gut microbiota

Author

Ahmed, Basma A., Ong, Frank J., Barra, Nicole G., Blondin, Denis P., Gunn, Elizabeth, Oreskovich, Stephan M., Szamosi, Jake C., Syed, Saad A., Hutchings, Emily K., Konyer, Norman B., Singh, Nina P., Yabut, Julian M., Desjardins, Eric M., Anhê, Fernando F., Foley, Kevin P., Holloway, Alison C., Noseworthy, Michael D., Haman, Francois, Carpentier, Andre C., Surette, Michael G., Schertzer, Jonathan D., Punthakee, Zubin, Steinberg, Gregory R., and Morrison, Katherine M.

Published
2021
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13. Sampling pattern discrepancy in the application of compressed sensing hyperpolarized xenon‐129 lung MRI.

Author

Tavakkoli, Mitra, Svenningsen, Sarah, Friedlander, Yonni, Konyer, Norman B., Nair, Parameswaran, and Noseworthy, Michael D.

Subjects
COMPRESSED sensing, LUNGS, MAGNETIC resonance imaging, SIGNAL-to-noise ratio, PHASE coding
Abstract

Although hyperpolarized (HP) 129Xe ventilation MRI can be carried out within a breath hold, it is still challenging for many sick patients. Compressed sensing (CS) is a viable alternative to accelerate this approach. However, undersampled images with identical sampling ratios differ from one another. Twenty subjects (n = 10 healthy and n = 10 patients with asthma) were scanned using a GE MR750 3 T scanner, acquiring fully sampled 2D multi‐slice HP 129Xe lung ventilation images (10 s breath hold, 128 × 80 (FE × PE—frequency encoding × phase encoding) and 16 slices). Using fully sampled data, 500 variable‐density Cartesian random undersampling patterns were generated, each at eight different sampling ratios from 10% to 80%. The parallel imaging and compressed sensing (PICS) command from BART was employed to reconstruct undersampled data. The signal to noise ratio (SNR), structural similarity index measurement (SSIM) and sidelobe to peak ratio of each were subsequently compared. There was a high degree of variation in both SNR and SSIM results from each of the 500 masks of each sampling rate. As the undersampling increases, there is more variation in the quantifying metrics, for both healthy and asthmatic individuals. Our study shows that random undersampling poses a significant challenge when applied at sampling ratios less than 60%, despite fulfilling CS's incoherency criteria. Such low sampling ratios will result in a large variety of undersampling patterns. Therefore, skipped segments of k‐space cannot be allowed to happen randomly at low sampling rates. By optimizing the sampling pattern, CS will reach its full potential and be able to be applied to a highly undersampled 129Xe lung dataset. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology.

Author

Xhima, Kristiana, Ottoy, Julie, Gibson, Erin, Zukotynski, Katherine, Scott, Christopher, Feliciano, Ginelle J., Adamo, Sabrina, Kuo, Phillip H., Borrie, Michael J., Chertkow, Howard, Frayne, Richard, Laforce, Robert, Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Sossi, Vesna, Thiel, Alexander, Soucy, Jean‐Paul, and Tardif, Jean‐Claude

Abstract

INTRODUCTION: Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co‐exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains poorly understood. METHODS: In a unique cohort of mixed Alzheimer's disease and moderate–severe SVD, we examined whether total and regional neuroimaging measures of SVD, white matter hyperintensities (WMH), and Aβ, as assessed by 18F‐AV45 positron emission tomography, exert additive or synergistic effects on hippocampal volume and shape. RESULTS: Frontal WMH, occipital WMH, and Aβ were independently associated with smaller hippocampal volume. Frontal WMH had a spatially distinct impact on hippocampal shape relative to Aβ. In contrast, hippocampal shape alterations associated with occipital WMH spatially overlapped with Aβ‐vulnerable subregions. DISCUSSION: Hippocampal degeneration is differentially sensitive to SVD and Aβ pathology. The pattern of hippocampal atrophy could serve as a disease‐specific biomarker, and thus guide clinical diagnosis and individualized treatment strategies for mixed dementia. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites

Author

Mikkelsen, Mark, Rimbault, Daniel L., Barker, Peter B., Bhattacharyya, Pallab K., Brix, Maiken K., Buur, Pieter F., Cecil, Kim M., Chan, Kimberly L., Chen, David Y.-T., Craven, Alexander R., Cuypers, Koen, Dacko, Michael, Duncan, Niall W., Dydak, Ulrike, Edmondson, David A., Ende, Gabriele, Ersland, Lars, Forbes, Megan A., Gao, Fei, Greenhouse, Ian, Harris, Ashley D., He, Naying, Heba, Stefanie, Hoggard, Nigel, Hsu, Tun-Wei, Jansen, Jacobus F.A., Kangarlu, Alayar, Lange, Thomas, Lebel, R. Marc, Li, Yan, Lin, Chien-Yuan E., Liou, Jy-Kang, Lirng, Jiing-Feng, Liu, Feng, Long, Joanna R., Ma, Ruoyun, Maes, Celine, Moreno-Ortega, Marta, Murray, Scott O., Noah, Sean, Noeske, Ralph, Noseworthy, Michael D., Oeltzschner, Georg, Porges, Eric C., Prisciandaro, James J., Puts, Nicolaas A.J., Roberts, Timothy P.L., Sack, Markus, Sailasuta, Napapon, Saleh, Muhammad G., Schallmo, Michael-Paul, Simard, Nicholas, Stoffers, Diederick, Swinnen, Stephan P., Tegenthoff, Martin, Truong, Peter, Wang, Guangbin, Wilkinson, Iain D., Wittsack, Hans-Jörg, Woods, Adam J., Xu, Hongmin, Yan, Fuhua, Zhang, Chencheng, Zipunnikov, Vadim, Zöllner, Helge J., and Edden, Richard A.E.

Published
2019
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23. Reduced Cognitive Assessment Scores Among Individuals With Magnetic Resonance Imaging–Detected Vascular Brain Injury

Author

Anand, Sonia S., Friedrich, Matthias G., Desai, Dipika, Schulze, Karleen M., Awadalla, Philip, Busseuil, David, Dummer, Trevor J.B., Jacquemont, Sébastien, Dick, Alexander, Kelton, David, Kirpalani, Anish, Lear, Scott A., Leipsic, Jonathan, Noseworthy, Michael D., Parker, Louise, Parraga, Grace, Poirier, Paul, Robson, Paula, Tardif, Jean-Claude, Teo, Koon, Vena, Jennifer, Yusuf, Salim, Moody, Alan R., Black, Sandra E., and Smith, Eric E.

Published
2020
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25. Big GABA: Edited MR spectroscopy at 24 research sites

Author

Mikkelsen, Mark, Barker, Peter B., Bhattacharyya, Pallab K., Brix, Maiken K., Buur, Pieter F., Cecil, Kim M., Chan, Kimberly L., Chen, David Y.-T., Craven, Alexander R., Cuypers, Koen, Dacko, Michael, Duncan, Niall W., Dydak, Ulrike, Edmondson, David A., Ende, Gabriele, Ersland, Lars, Gao, Fei, Greenhouse, Ian, Harris, Ashley D., He, Naying, Heba, Stefanie, Hoggard, Nigel, Hsu, Tun-Wei, Jansen, Jacobus F.A., Kangarlu, Alayar, Lange, Thomas, Lebel, R. Marc, Li, Yan, Lin, Chien-Yuan E., Liou, Jy-Kang, Lirng, Jiing-Feng, Liu, Feng, Ma, Ruoyun, Maes, Celine, Moreno-Ortega, Marta, Murray, Scott O., Noah, Sean, Noeske, Ralph, Noseworthy, Michael D., Oeltzschner, Georg, Prisciandaro, James J., Puts, Nicolaas A.J., Roberts, Timothy P.L., Sack, Markus, Sailasuta, Napapon, Saleh, Muhammad G., Schallmo, Michael-Paul, Simard, Nicholas, Swinnen, Stephan P., Tegenthoff, Martin, Truong, Peter, Wang, Guangbin, Wilkinson, Iain D., Wittsack, Hans-Jörg, Xu, Hongmin, Yan, Fuhua, Zhang, Chencheng, Zipunnikov, Vadim, Zöllner, Helge J., and Edden, Richard A.E.

Published
2017
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26. EFFECTS OF VASCULAR BURDEN ON COGNITION ARE MEDIATED BY ATROPHY, AMYLOID, AND GLUCOSE METABOLISM: A MULTI-CENTRE MIXED COHORT OF SMALL VESSEL DISEASE AND ALZHEIMER'S PATHOLOGY

Author

Ottoy, Julie, Ozzoude, Miracle, Zukotynski, Katherine, Adamo, Sabrina, Scott, Christopher, Gaudet, Vincent, Ramirez, Joel, Swardfager, Walter, Cogo-Moreira, Hugo, Lam, Benjamin, Bhan, Aparna, Mojiri, Parisa, Kang, Min Su, Rabin, Jennifer, Kiss, Alex, Strother, Stephen, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert, Jr., Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Kuo, Phillip H., Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, Black, Sandra E., and Goubran, Maged

Published
2024
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30. The Use of Random Forests to Classify Amyloid Brain PET

Author

Zukotynski, Katherine, Gaudet, Vincent, Kuo, Phillip H., Adamo, Sabrina, Goubran, Maged, Scott, Christopher, Bocti, Christian, Borrie, Michael, Chertkow, Howard, Frayne, Richard, Hsiung, Robin, Laforce, Robert, Jr, Noseworthy, Michael D., Prato, Frank S., Sahlas, Demetrios J., Smith, Eric E., Sossi, Vesna, Thiel, Alexander, Soucy, Jean-Paul, Tardif, Jean-Claude, and Black, Sandra E.

Published
2019
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34. A review of brain regions and associated post-concussion symptoms.

Author

Danielli, Ethan, Simard, Nicholas, DeMatteo, Carol A., Kumbhare, Dinesh, Ulmer, Stephan, and Noseworthy, Michael D.

Subjects
BRAIN concussion, BRAIN anatomy, GRAY matter (Nerve tissue), WHITE matter (Nerve tissue), SYMPTOMS, DIAGNOSTIC imaging
Abstract

The human brain is an exceptionally complex organ that is comprised of billions of neurons. Therefore, when a traumatic event such as a concussion occurs, somatic, cognitive, behavioral, and sleep impairments are the common outcome. Each concussion is unique in the sense that the magnitude of biomechanical forces and the direction, rotation, and source of those forces are different for each concussive event. This helps to explain the unpredictable nature of post-concussion symptoms that can arise and resolve. The purpose of this narrative review is to connect the anatomical location, healthy function, and associated post-concussion symptoms of some major cerebral gray and white matter brain regions and the cerebellum. As a non-exhaustive description of post-concussion symptoms nor comprehensive inclusion of all brain regions, we have aimed to amalgamate the research performed for specific brain regions into a single article to clarify and enhance clinical and research concussion assessment. The current status of concussion diagnosis is highly subjective and primarily based on self-report of symptoms, so this review may be able to provide a connection between brain anatomy and the clinical presentation of concussions to enhance medical imaging assessments. By explaining anatomical relevance in terms of clinical concussion symptom presentation, an increased understanding of concussions may also be achieved to improve concussion recognition and diagnosis. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Comparison of ventilation defects quantified by Technegas SPECT and hyperpolarized 129Xe MRI.

Author

Radadia, Nisarg, Friedlander, Yonni, Priel, Eldar, Konyer, Norman B., Chynna Huang, Jamal, Mobin, Farncombe, Troy, Marriott, Christopher, Finley, Christian, Agzarian, John, Dolovich, Myrna, Noseworthy, Michael D., Nair, Parameswaran, Shargall, Yaron, and Svenningsen, Sarah

Subjects
SINGLE-photon emission computed tomography, MAGNETIC resonance imaging, VENTILATION, OBSTRUCTIVE lung diseases, K-means clustering
Abstract

Introduction: The ideal contrast agents for ventilation SPECT and MRI are Technegas and 129Xe gas, respectively. Despite increasing interest in the clinical utility of ventilation imaging, these modalities have not been directly compared. Therefore, our objective was to compare the ventilation defect percent (VDP) assessed by Technegas SPECT and hyperpolarized 129Xe MRI in patients scheduled to undergo lung cancer resection with and without pre-existing obstructive lung disease. Methods: Forty-one adults scheduled to undergo lung cancer resection performed same-day Technegas SPECT, hyperpolarized 129Xe MRI, spirometry, and diffusing capacity of the lung for carbon monoxide (DLCO). Ventilation abnormalities were quantified as the VDP using two different methods: adaptive thresholding (VDPT) and k-means clustering (VDPK). Correlation and agreement between VDP quantified by Technegas SPECT and 129Xe MRI were determined by Spearman correlation and Bland-Altman analysis, respectively. Results: VDP measured by Technegas SPECT and 129Xe MRI were correlated (VDPT: r = 0.48, p = 0.001; VDPK: r = 0.63, p < 0.0001). A 2.0% and 1.6% bias towards higher Technegas SPECT VDP was measured using the adaptive threshold method (VDPT: 23.0% ± 14.0% vs. 21.0% ± 5.2%, p = 0.81) and k-means method (VDPK: 9.4% ± 9.4% vs. 7.8% ± 10.0%, p = 0.02), respectively. For both modalities, higher VDP was correlated with lower FEV1/FVC (SPECT VDPT: r = -0.38, p = 0.01; MRI VDPK: r=-0.46, p = 0.002) and DLCO (SPECT VDPT: r=-0.61, p < 0.0001; MRI VDPK: r = -0.68, p < 0.0001). Subgroup analysis revealed that VDP measured by both modalities was significantly higher for participants with COPD (n = 13) than those with asthma (n = 6; SPECT VDPT: p = 0.007, MRI VDPK: p = 0.006) and those with no history of obstructive lung disease (n = 21; SPECT VDPT: p = 0.0003, MRI VDPK: p = 0.0003). Discussion: The burden of ventilation defects quantified by Technegas SPECT and 129Xe MRI VDP was correlated and greater in participants with COPD when compared to those without. Our observations indicate that, despite substantial differences between the imaging modalities, quantitative assessment of ventilation defects by Technegas SPECT and 129Xe MRI is comparable. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Effect of Cognitive Reserve on the Association of Vascular Brain Injury With Cognition

Author

Durrani, Romella, Friedrich, Matthias G., Schulze, Karleen M., Awadalla, Philip, Balasubramanian, Kumar, Black, Sandra E., Broet, Philippe, Busseuil, David, Desai, Dipika, Dummer, Trevor, Dick, Alexander, Hicks, Jason, Iype, Thomas, Kelton, David, Kirpalani, Anish, Lear, Scott A., Leipsic, Jonathon, Li, Wei, McCreary, Cheryl R., Moody, Alan R., Noseworthy, Michael D., Parraga, Grace, Poirier, Paul, Rangarajan, Sumathy, Szczesniak, Dorota, Szuba, Andrzej, Tardif, Jean-Claude, Teo, Koon, Vena, Jennifer E., Zatonska, Katarzyna, Zimny, Anna, Lee, Douglas S., Yusuf, Salim, Anand, Sonia S., and Smith, Eric E.

Subjects
Adult, Aged, 80 and over, Brain Infarction, Male, Middle Aged, Cognition, Cross-Sectional Studies, Cognitive Reserve, Humans, Cognitive Dysfunction, Female, Research Article, Aged
Abstract

Background and Objectives To determine whether cognitive reserve attenuates the association of vascular brain injury with cognition. Methods Cross-sectional data were analyzed from 2 harmonized studies: the Canadian Alliance for Healthy Hearts and Healthy Minds (CAHHM) and the Prospective Urban and Rural Epidemiology (PURE) study. Markers of cognitive reserve were education, involvement in social activities, marital status, height, and leisure physical activity, which were combined into a composite score. Vascular brain injury was defined as nonlacunar brain infarcts or high white matter hyperintensity (WMH) burden on MRI. Cognition was assessed using the Montreal Cognitive Assessment Tool (MoCA) and the Digit Symbol Substitution Test (DSST). Results There were 10,916 participants age 35–81. Mean age was 58.8 years (range 35–81) and 55.8% were female. Education, moderate leisure physical activity, being in a marital partnership, being taller, and participating in social groups were each independently associated with higher cognition, as was the composite cognitive reserve score. Vascular brain injury was associated with lower cognition (β –0.35 [95% confidence interval [CI] –0.53 to −0.17] for MoCA and β −2.19 [95% CI −3.22 to −1.15] for DSST) but the association was not modified by the composite cognitive reserve variable (interaction p = 0.59 for MoCA and p = 0.72 for DSST). Conclusions Both vascular brain injury and markers of cognitive reserve are associated with cognition. However, the effects were independent such that the adverse effects of covert vascular brain injury were not attenuated by higher cognitive reserve. To improve cognitive brain health, interventions to both prevent cerebrovascular disease and promote positive lifestyles are needed.

Published
2021

46. Nailfold capillaroscopy and deep learning in diabetes.

Author

Shah, Reema, Petch, Jeremy, Nelson, Walter, Roth, Karsten, Noseworthy, Michael D., Ghassemi, Marzyeh, and Gerstein, Hertzel C.

Subjects
SIGNAL convolution, DEEP learning, GLYCOSYLATED hemoglobin, RECEIVER operating characteristic curves, CAPILLAROSCOPY, TYPE 1 diabetes
Abstract

Copyright of Journal of Diabetes is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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