23 results on '"Oliveira, Nádia"'
Search Results
2. NMR analysis seeking for cognitive decline and dementia metabolic markers in plasma from aged individuals.
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Conde, Ricardo, Oliveira, Nádia, Morais, Elisabete, Amaral, Ana Paula, Sousa, Adriana, Graça, Gonçalo, and Verde, Ignacio
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- 2024
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3. Effects of bisphenol A on human umbilical arteries
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Oliveira, Nádia, Marcelino, Helena, Azevedo, Regina, and Verde, Ignacio
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- 2023
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4. Identification of Urine Metabolic Markers of Stroke Risk Using Untargeted Nuclear Magnetic Resonance Analysis.
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Oliveira, Nádia, Sousa, Adriana, Amaral, Ana Paula, Conde, Ricardo, and Verde, Ignacio
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NUCLEAR magnetic resonance spectroscopy , *STROKE , *NUCLEAR magnetic resonance , *DISEASE risk factors , *LONG-term care facilities , *OLDER people - Abstract
Stroke remains the second leading cause of mortality worldwide, and the third leading cause of death and morbidity combined, affecting more than 12 million people every year. Stroke pathophysiology results from complex interactions of several risk factors related to age, family history, gender, lifestyle, and the presence of cardiovascular and metabolic diseases. Despite all the evidence, it is not possible to fully prevent stroke onset. In recent years, there has been an exploration of innovative methodologies for metabolite analysis aimed at identifying novel stroke biomarkers. Utilizing Nuclear Magnetic Resonance (NMR) spectroscopy, we investigated small molecule variations in urine across different stages of stroke risk. The Framingham Stroke Risk Score was used in people over 63 years of age living in long-term care facilities (LTCFs) to calculate the probability of suffering a stroke: low stroke risk (LSR, control), moderate stroke risk (MSR), and high stroke risk (HSR). Univariate statistical analysis showed that urinary 4-hydroxyphenylacetate levels increased while glycolate levels decreased across the different stroke risk groups, from the LSR to the HSR groups. Trimethylamine N-oxide (TMAO) had average concentration values that were significantly higher in elderly people in the HSR group, while trigonelline levels were significantly lower in the MSR group. These metabolic markers can be used for early detection and to differentiate stages of stroke risk more efficiently. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Correction to: Effects of bisphenol A on human umbilical arteries
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Oliveira, Nádia, Marcelino, Helena, Azevedo, Regina, and Verde, Ignacio
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- 2023
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6. HLA‐A23/HLA‐A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasma.
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Cardoso, Elsa M., Lourenço‐Gomes, Vânia, Esgalhado, André J., Reste‐Ferreira, Débora, Oliveira, Nádia, Amaral, Ana Saraiva, Martinho, António, Gama, Jorge M. R., Verde, Ignácio, Lourenço, Olga, Fonseca, Ana M., Buchli, Rico, and Arosa, Fernando A.
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DEMENTIA ,ALZHEIMER'S disease ,OLDER people ,SEROTYPES ,NEURAL development - Abstract
MHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma‐derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/pre‐dementia (NpD, n = 28), or with dementia (D, n = 28) was studied. Multivariate analysis was used to examine the influence of dementia and HLA class I serotype on sHLA class I levels, and to compare sHLA class I within four groups according to the presence or absence of HLA‐A23/A24 and dementia. HLA‐A23/A24 and dementia, but not age, significantly influenced the level of sHLA class I. Importantly, the concurrent presence of HLA‐A23/A24 and dementia was associated with higher levels of sHLA class I (p < 0.001). This study has shown that the simultaneous presence of HLA‐A23/HLA‐A24 and dementia is associated with high levels of serum sHLA class I molecules. Thus, sHLA class I could be considered a biomarker of neurodegeneration in certain HLA class I carriers. [ABSTRACT FROM AUTHOR]
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- 2023
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7. Searching for Metabolic Markers of Stroke in Human Plasma via NMR Analysis.
- Author
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Oliveira, Nádia, Sousa, Adriana, Amaral, Ana Paula, Graça, Gonçalo, and Verde, Ignacio
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STROKE , *DISEASE risk factors , *LONG-term care facilities , *CREATININE , *SMALL molecules - Abstract
More than 12 million people around the world suffer a stroke every year, one every 3 s. Stroke has a variety of causes and is often the result of a complex interaction of risk factors related to age, genetics, gender, lifestyle, and some cardiovascular and metabolic diseases. Despite this evidence, it is not possible to prevent the onset of stroke. The use of innovative methods for metabolite analysis has been explored in the last years to detect new stroke biomarkers. We use NMR spectroscopy to identify small molecule variations between different stages of stroke risk. The Framingham Stroke Risk Score was used in people over 63 years of age living in long-term care facilities (LTCF) to calculate the probability of suffering a stroke. Using this parameter, three study groups were formed: low stroke risk (LSR, control), moderate stroke risk (MSR) and high stroke risk (HSR). Univariate statistical analysis showed seven metabolites with increasing plasma levels across different stroke risk groups, from LSR to HSR: isoleucine, asparagine, formate, creatinine, dimethylsulfone and two unidentified molecules, which we termed "unknown-1" and "unknown-3". These metabolic markers can be used for early detection and to detect increasing stages of stroke risk more efficiently. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Optimal portfolios based on stock characteristics: construction and performance for the US market
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Oliveira, Nádia Raquel de Araújo, Areal, Nelson, and Universidade do Minho
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Stock market ,Construção de carteiras ,Fundamental analysis ,Análise fundamental ,Performance analysis ,Ciências Sociais::Economia e Gestão ,Rendibilidades ,Portfolio construction ,Análise de performance ,Returns ,Mercado de ações - Abstract
Dissertação de mestrado em Finanças, Existe uma vasta literatura sobre criação de carteiras de investimentos, iniciada por Markowitz (1952) e prolongada ao longo dos anos com contribuições sobre novas abordagens e técnicas. Outro ramo relevante da literatura em Finanças concentra-se na análise fundamental e na investigação de métodos para prever rendibilidades futuras. Esta dissertação situa-se na interseção destes dois ramos, uma vez que tem como principal objetivo incorporar a análise fundamental na otimização de carteiras. Para atingir este objetivo, este estudo foca-se no mercado de ações dos EUA entre 1998 e 2021. Os dados são provenientes da Refinitiv Datastream e filtrados e processados seguindo as orientações de Landis e Skouras (2021). Para a criação das carteiras, as rendibilidades esperadas e as matrizes de covariância são produzidas com a estimação de um modelo que relaciona diretamente as rendibilidades esperadas com características das ações, como rácios contabilísticos. Para compreender se possíveis ganhos de performance advêm das rendibilidades esperadas, das matrizes de covariância, ou de ambas, carteiras com diferentes pressupostos são construídas e comparadas com as “Carteiras fundamentais totalmente otimizadas” (Fully optimized fundamental portfolios) através de várias medidas de performance. Estas são construídas seguindo Markowitz (1952), incorporando tanto as rendibilidades esperadas como as estimativas da matriz de covariância. Os resultados são comparados com os encontrados no estudo de Lyle e Yohn (2021). As principais conclusões desta dissertação são de que a incorporação de estimativas de rendibilidades esperadas com base nas características das ações e matrizes de covariância na otimização pode traduzir-se em ganhos na performance da carteira. No entanto, estes ganhos são, em quase todos os casos, apenas notórios quando há uma restrição de pesos superiores a zero (sem vendas a descoberto). Estes resultados são também dependentes do período de tempo em análise e da inclusão de ações de baixa capitalização no universo de investimentos., There is a vast literature on investment portfolio creation, starting with Markowitz (1952) and prolonging itself throughout the years with numerous contributions on new approaches and improved techniques. Another relevant branch of Finance literature focuses on fundamental analysis and seeks to find methods to predict future returns. This dissertation lies in the intersection between these two branches, as its main objective is to incorporate fundamental analysis in mean variance portfolio optimization. In order to achieve this objective, this study focuses on the US stock market between 1998 and 2021. The data is retrieved from Refinitiv Datastream and cleaned and processed following Landis and Skouras (2021) guidelines. For the creation of the portfolios, both expected returns and covariance matrices are produced with the estimation of a model that directly links expected returns with stock characteristics, including accounting ratios. To understand whether possible gains in performance arise from the expected returns, covariance matrixes, or both, several portfolios with different assumptions are constructed and compared to the “Fully optimized fundamental portfolios” with several performance measures. These Fully optimized portfolios are constructed in Markowitz's (1952) style, incorporating both the expected returns and covariance matrix estimations. Results are compared with the ones found in Lyle and Yohn (2021) study. The main conclusions of this dissertation are that incorporating estimates of expected returns based on stock characteristics and covariance matrices in mean-variance optimization can produce an improved portfolio performance. However, this improvement is almost in all cases only noticeable when there is a constraint on weights to be higher than zero (no short selling). These results are also dependent on the time period under analysis and the inclusion of small stocks in the investment set.
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- 2023
9. Development and application of a QuEChERS-based extraction method for the analysis of 55 pesticides in the bivalve Scrobicularia plana by GC-MS/MS
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Cruzeiro, Catarina, Rodrigues-Oliveira, Nádia, Velhote, Susana, Pardal, Miguel Ângelo, Rocha, Eduardo, and Rocha, Maria João
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- 2016
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10. c-Src function is necessary and sufficient for triggering microglial cell activation
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Socodato, Renato, Portugal, Camila C., Domith, Ivan, Oliveira, Nádia A., Coreixas, Vivian S. M., Loiola, Erick C., Martins, Tânia, Santiago, Ana Raquel, Paes-de-Carvalho, Roberto, Ambrósio, António F., and Relvas, João B.
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- 2015
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11. The use of a virtual platform for social mobilization in the confrontation of arboviruses and control of Aedes aegypti
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Silveira, Danielle Costa, Carmo, Rose Ferraz, Menezes, Fernanda Carvalho de, Oliveira, Juliana Ferreira de, Oliveira, Nádia Ladendorff de, Aranha, Vitor Davis Teixeira, Luz, Zélia Maria Profeta da, and Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), Fundação Oswaldo Cruz (Fiocruz)
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Arbovirus Infections ,Health Communication ,Social Media ,Community Participation ,Health Promotion ,Participación de la Comunidad ,promoção da saúde ,Promoção da Saúde ,Comunicación en Salud ,Infecciones por Arbovirus ,Medios de Comunicación Sociales ,Promoción de la Salud ,arboviroses ,Communication. Mass media ,mobilização social ,P87-96 ,Arboviroses ,Comunicação em Saúde ,Mídias Sociais ,Mobilização Social ,comunicação em saúde ,mídias sociais ,Public aspects of medicine ,RA1-1270 - Abstract
Social mobilization for dengue, zika and chikungunya prevention and control of Aedes aegypti has been a challenge in the country. This paper presents the process of elaboration of a virtual platform, including the composition of its collection and the exploratory analysis of its use, as a tool in a social mobilization proposal that encompasses the creation of popular committees in the territories for the confrontation of the three diseases and vector. The construction of the platform considered: ease of use; access; material storage; interactivity and database for data monitoring. The selection of the collection was based on the following criteria: technical, considering source and authorship; accuracy, regarding the agreement between health information and evidence; legibility, ensuring the understanding by different groups. The exploratory analysis used the platform database. The results showed the platform as a tool which can contribute to health communication and information in this proposal of social mobilization. La movilización social para combatir el dengue, zika, chikungunya y control de Aedes ha sido un desafío. Este artículo presenta el proceso de elaboración de una plataforma virtual, que incluye la composición de su acervo y el análisis exploratorio de su uso, como herramienta en una propuesta de movilización social que implica la creación de comités populares en los territorios para enfrentar las enfermedades y el vector. La construcción de la plataforma consideró: facilidad para usuario; acceso; almacenamiento de material; interactividad y bases de datos para el monitoreo. La selección del acervo se basó en criterios: técnico, con fuente y autoría; precisión, concordancia entre información y evidencia en salud; legibilidad, para garantizar la comprensión por diferentes grupos. El análisis utilizó datos de la plataforma. Los resultados mostraron que la plataforma puede ser una herramienta para contribuir a la comunicación e información de salud en esta propuesta de movilización social. A mobilização social para o enfrentamento da dengue, zika, chikungunya e controle do Aedes aegypti tem sido um desafio no país. Esse artigo apresenta o processo de elaboração de uma plataforma virtual, incluindo a composição do seu acervo e a análise exploratória do seu uso, como ferramenta, numa proposta de mobilização social que envolve a criação de comitês populares nos territórios para o enfrentamento das três doenças e vetor. A construção da plataforma considerou: facilidade para usuário; acesso; armazenamento de material; interatividade e banco para monitoramento de dados. A seleção do acervo baseou-se em critérios: técnico, referente à fonte e autoria; acurácia, concordância entre informação e evidência em saúde; e legibilidade, garantindo a compreensão por diferentes grupos. A análise exploratória utilizou o banco de dados da plataforma. Os resultados apontaram a plataforma como uma ferramenta que pode contribuir com a comunicação e informação em saúde nessa proposta de mobilização social.
- Published
- 2021
12. (Re)futuring Tourism Businesses: A Framework for a Sustainable Tourism Online Course
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Oliveira, Nádia Carreira and Dias, Francisco Teixeira Pinto
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Sustainability Marketing ,Education for Sustainability ,COVID-19 ,Responsible Leadership ,Sustainable Tourism ,Ciências Sociais::Economia e Gestão [Domínio/Área Científica] ,Tourism Businesses - Abstract
For the last two decades, the Travel & Tourism industry has gradually become one of the critical engines of the world’s economic and social development, while also a considerable contributor to unsustainable patterns and its consequent damaging effects. The COVID-19 pandemic that stormed the planet at the beginning of this year has created an inflexion point on the industry’s soaring growth trajectories, severely affecting and compromising both its current and future strength and vitality. Concurrently, it has presented time for reflection. The rhetoric for the need to transform the industry has underpinned the numerous pleas and expressed commitment from industry experts, to move beyond ‘business as usual’ and ‘build back better’, towards a shift to a more sustainable and equitable tourism. As a by-product of the internship at Turismo Centro de Portugal, this report consists of a framework proposal for a holistic, seven-week sustainable tourism free online course, to be provided by Turismo Centro de Portugal to its business stakeholders. The underlying idea relies on the assumption that businesses have an essential role to play in transforming the industry and thus, that education for sustainability is an imperative for encouraging them to become catalysing agents, in creating a novel and improved version of tourism and tackling its inherent challenges. Furthermore, as a Regional Tourism Organisation and due to the visibility and the interconnectedness with its stakeholders, Turismo Centro de Portugal is favourably positioned to promote and foster shared sustainable vision for the destination, namely through education. The framework hence serves the seminal purpose of urging Turismo Centro de Portugal to actively engage its business stakeholders to embark on a shared sustainable tourism quest. Given the complex nature of the tourism industry and the proposed objectives of the course, the literary review undertaken serves to substantiate its relevance, content and design structure. Grounded on a theoretical approach based on scientific and empirical research, statistical data and education industry benchmark research and analysis, it reaches the proposed result, both through deductive reasoning - from reading and critical analysis - and existing courses frameworks, framed under the economics, management, tourism, sustainability & sustainable development, innovation, marketing and leadership thematic. The framework is, however, not free from bias since it also relies on personal empirical and practical knowledge. This invariably means that the input from scholars and practitioners is essential.
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- 2021
13. The survival, development, and reproduction of Gonipterus platensis (Coleoptera: Curculionidae) on the main Eucalyptus (Myrtaceae) genotypes planted in Brazil.
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Cristina de Oliveira, Nádia, Fonseca Ribeiro, Murilo, Ottati, Angelo, de Souza Tavares, Wagner, Eduardo Serrão, José, Cola Zanuncio, José, Zanetti, Ronald, and Frederico Wilcken, Carlos
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EUCALYPTUS ,CURCULIONIDAE ,EUCALYPTUS grandis ,BEETLES ,EUCALYPTUS camaldulensis ,MYRTACEAE ,BEETLE anatomy - Abstract
Background. Gonipterus platensis Marelli (Coleoptera: Curculionidae) is the main defoliating beetle of Eucalyptus L'Hér. (Myrtaceae) plants worldwide. The suitability of Eucalyptus to this pest varies among host plant genotypes. The objective of this study was to evaluate the development, reproduction, and survival of G. platensis on Eucalyptus species and hybrids to assess their suitability to this insect pest in Brazil. Methods. The survival, development, and reproduction parameters were evaluated with G. platensis feeding leaves of Eucalyptus camaldulensis Dehnh., Eucalyptus grandis W. Hill., Eucalyptus urophylla S.T. Blake and on the hybrids of E. grandis xE. urophylla 'H13' and 'VR3748' in the laboratory. Methods. The survival, development, and reproduction parameters were evaluated with G. platensis feeding leaves of Eucalyptus camaldulensis Dehnh., Eucalyptus grandis W. Hill., Eucalyptus urophylla S.T. Blake and on the hybrids of E. grandis xE. urophylla 'H13' and 'VR3748' in the laboratory. Synthesis. Eucalyptus urophylla is the most suitable host for G. platensis survival, development, and reproduction, while E. grandis and E. camaldulensis are the least suitable. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Dopamine-Induced Ascorbate Release From Retinal Neurons Involves Glutamate Release, Activation of AMPA/Kainate Receptors and Downstream Signaling Pathways.
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Portugal, Camila Cabral, da Encarnação, Thaísa Godinho, Domith, Ivan, dos Santos Rodrigues, Alexandre, de Oliveira, Nádia Almeida, Socodato, Renato, and Paes-de-Carvalho, Roberto
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DOPAMINE ,GLUTAMIC acid ,CENTRAL nervous system ,BIOAVAILABILITY ,ANTIOXIDANTS - Abstract
Ascorbate, the reduced form of Vitamin C, is one of the most abundant and important low-molecular weight antioxidants in living tissues. Most animals synthesize vitamin C, but some primates, including humans, have lost this capacity due to disruption in L-gulono-gamma-lactone oxidase gene. Because of this incapacity, those animals must obtain Vitamin C from the diet. Ascorbate is highly concentrated in the central nervous system (CNS), including the retina, and plays essential roles in neuronal physiology. Ascorbate transport into cells is controlled by Sodium Vitamin C Co-Transporters (SVCTs). There are four SVCT isoforms and SVCT2 is the major isoform controlling ascorbate transport in the CNS. Regarding ascorbate release from retinal neurons, Glutamate, by activating its ionotropic receptors leads to ascorbate release via the reversion of SVCT2. Moreover, dopamine, via activation of D
1 receptor/cyclic AMP/EPAC2 pathway, also induces ascorbate release via SVCT2 reversion. Because the dopaminergic and glutamatergic systems are interconnected in the CNS, we hypothesized that dopamine could regulate ascorbate release indirectly, via the glutamatergic system. Here we reveal that dopamine increases the release of D-Aspartate from retinal neurons in a way independent on calcium ions and dependent on excitatory amino acid transporters. In addition, dopamine-dependent SVCT2 reversion leading to ascorbate release occurs by activation of AMPA/Kainate receptors and downstream ERK/AKT pathways. Overall, our data reveal a dopamine-to-glutamate signaling that regulates the bioavailability of ascorbate in neuronal cells. [ABSTRACT FROM AUTHOR]- Published
- 2019
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15. Voice acoustic profi le of males exposed to occupational infrasound and low-frequency noise
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Mendes, Ana, Bonança, Íris, Jorge, Ana, Mariana Alves-Pereira, Castelo-Branco, Nuno A. A., Caetano, Marlene, Oliveira, Nádia, Graça, Andreia, Santos, Carolina, and Ferraria, Renata
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vocal folds ,vibroacoustic disease ,voice acoustic analysis ,Infrasound and low frequency noise-exposure - Abstract
Background: Vibroacoustic disease (VAD) is a systematic pathology characterized by the abnormal growth of extra-cellular matrices in the absence of infl ammatory processes, namely collagen and elastin, both of which are abundant in the basement membrane zone of the vocal folds. VAD can develop due to long-term exposure to infrasound and low-frequency noise (ILFN
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- 2014
16. Popcorn genotypes resistance to fall armyworm.
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de Oliveira, Nádia Cristina, Suzukawa, Andréia Kazumi, Pereira, Carolina Bertuzzi, Santos, Hayssa Vilela, Hanel, Aldo, de Albuquerque, Fernando Alves, and Scapim, Carlos Alberto
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POPCORN , *FALL armyworm , *INSECT larvae , *ANTIBIOSIS , *DRUG resistance , *INSECT pest control - Abstract
The aim of this study was to evaluate popcorn genotypes for resistance to the fall armyworm, Spodoptera frugiperda. The experiment used a completely randomized design with 30 replicates. The popcorn genotypes Aelton, Arzm 05 083, Beija-Flor, Colombiana, Composto Chico, Composto Gaúcha, Márcia, Mateus, Ufvm Barão Viçosa, Vanin, and Viviane were evaluated,along with the common maize variety Zapalote Chico. Newly hatched fall armyworm larvae were individually assessed with regard to biological development and consumption of food. The data were subjected to multivariate analyses of variance and genetic divergence among genotypes was evaluated through the clustering methods of Tocher based on generalized Mahalanobis distances and canonical variable analyses. Seven popcorn genotypes, namely, Aelton, Arzm 05 083, Composto Chico, Composto Gaúcha, Márcia, Mateus, and Viviane,were shown to form a cluster (cluster I) that had antibiosis as the mechanism of resistance to the pest. Cluster I genotypes and the Zapalote Chico genotype could be used for stacking genes for antibiosis and non-preference resistance. [ABSTRACT FROM AUTHOR]
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- 2018
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17. Voice acoustic profile of males exposed to occupational infrasound and low-frequency noise.
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Mendes, Ana P., Bonança, Íris, Jorge, Ana, Alves-Pereira, Mariana, Castelo Branco, Nuno A. A., Caetano, Marlene, Oliveira, Nádia, Graça, Andreia, Santos, Carolina, and Ferraria, Renata
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VOICE disorders ,INFRASONIC waves ,COLLAGEN ,ELASTIN ,PHONETICS - Abstract
Background: Vibroacoustic disease (VAD) is a systematic pathology characterized by the abnormal growth of extra-cellular matrices in the absence of inflammatory processes, namely collagen and elastin, both of which are abundant in the basement membrane zone of the vocal folds. VAD can develop due to long-term exposure to infrasound and low-frequency noise (ILFN, <500 Hz). Mendes et al. (2006, 2008 and 2012) revealed that ILFN-exposed males and females presented an increased fundamental frequency (F0), decreased jitter %, and reduced maximum phonation frequency range, when compared with normative data. Temporal measures of maximum phonation time and S/Z ratio were generally reduced. Study Aims: Herein, the same voice acoustic parameters of 48 males, 36 airline pilots and 12 cabin crewmembers (age range 25-60 years) were studied, and the effects and interaction of age and years of ILFN exposure were investigated within those parameters. ILFN-exposure time (i.e. years of professional activity) ranged from 3.5 to 36 years. Materials and Methods: Spoken and sung phonatory tasks were recorded with a DA-P1 Tascam DAT and a C420III PP AKG head-worn microphone, positioned at 3 cm from the mouth. Acoustic analyses were performed using KayPENTAX Computer Speech Lab and Multi-Dimensional Voice Program. Results: Results revealed that even though pilots and cabin crewmembers were exposed to occupational environments with distinct (ILFN-rich) acoustical frequency distributions and sound pressure levels, differences in the vocal acoustic parameters were not evident. Analyzing data from both professional groups (N = 48) revealed that F0 increased significantly with the number of years of professional activity. Conclusion: These results strongly suggest that the number of years of professional activity (i.e. total ILFN exposure time) had a significant effect on F0. Furthermore, they may reflect the histological changes specifically observed on the vocal folds of ILFN-exposed professionals. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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18. Ergonomic work analysis as a tool of prevention for the occupational safety and health management system.
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de Miranda Prottes, Verônica, Oliveira, Nádia Cristina, and de Oliveira Andrade, Alessandra Barbosa
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TASK performance ,ERGONOMICS -- Evaluation ,RISK assessment ,INDUSTRIAL safety ,RISK management in business - Abstract
This paper introduces the Ergonomic Work Analysis as a relevant instrument to identify the risks in occupational environments through the investigation of factors that influence the relationship between the worker and the productive process. It draws a parallel between the several aspects of risk identification in traditional tools of Health and Safety Management and the factors embraced by the Ergonomic Work Analysis, showing that the ergonomic methodology is able to go deeper in the scenarios of possible incident causes. This deepening enables the establishment of a relationship between the work context and the upcoming damage to the physical integrity of the worker. It acts as a complementary instrument in the traditional approach to the risk management. In order to explain the application of this methodology in a preventive way, it is presented a case study of a coal mill inspector in a siderurgic company. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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19. Effects of cardiotonic steroids on isolated perfused kidney and NHE3 activity in renal proximal tubules.
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Godinho, Alana N., Costa, Graciana T., Oliveira, Nádia O., Cardi, Bruno A., Uchoa, Daniel Esdras A., Silveira, Edilberto R., Quintas, Luis Eduardo M., Noël, François G., Fonteles, Manassés C., Carvalho, Krishnamurti M., Santos, Cláudia F., Lessa, Lucília M.A., and do Nascimento, Nilberto R.F.
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CARDIAC glycosides , *KIDNEY tubules , *SODIUM-potassium-chloride cotransporters , *HOMEOSTASIS , *DOWNREGULATION , *NATRIURESIS , *PHYSIOLOGY - Abstract
Cardiotonic steroids (CS) are known as modulators of sodium and water homeostasis. These compounds contribute to the excretion of sodium under overload conditions due to its natriuretic property related to the inhibition of the renal Na + /K + -ATPase (NKA) pump α1 isoform. NHE3, the main route for Na + reabsorption in the proximal tubule, depends on the Na + gradient generated by the NKA pump. In the present study we aimed to investigate the effects of marinobufagin (MBG) and telocinobufagin (TBG) on the renal function of isolated perfused rat kidney and on the inhibition of NKA activity. Furthermore, we investigated the mechanisms for the cardiotonic steroid-mediated natriuretic effect, by evaluating and comparing the effects of bufalin (BUF), ouabain (OUA), MBG and TBG on NHE3 activity in the renal proximal tubule in vivo. TBG significantly increased GFR, UF, natriuresis and kaliuresis in isolated perfused rat kidney, and inhibits the activity of NKA at a much higher rate than MBG. By stationary microperfusion technique, the perfusion with BUF, OUA, TBG or MBG promoted an inhibitory effect on NHE3 activity, whereas BUF was the most effective agent, and demonstrated a dose-dependent response, with maximal inhibition at 50 nM. Furthermore, our data showed the role of NKA-Src kinase pathway in the inhibition of NHE3 by CS. Finally, a downstream step, MEK1/2-ERK1/2 was also investigated, and, similar to Src inhibition, the MEK1/2 inhibitor (U0126) suppressed the BUF effect. Our findings indicate the involvement of NKA-SRc-Kinase-Ras-Raf-ERK1/2 pathway in the downregulation of NHE3 by cardiotonic steroids in the renal proximal tubule, promoting a reduction of proximal sodium reabsorption and natriuresis. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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20. Multi-matrix quantification and risk assessment of pesticides in the longest river of the Iberian peninsula.
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Cruzeiro, Catarina, Pardal, Miguel Ângelo, Rodrigues-Oliveira, Nádia, Castro, L. Filipe C., Rocha, Eduardo, and Rocha, Maria João
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ECOLOGICAL risk assessment , *ENVIRONMENTAL quality , *BIOMAGNIFICATION , *FOOD chains , *PARTITION coefficient (Chemistry) , *GAS chromatography/Mass spectrometry (GC-MS) - Abstract
The distribution of pesticides in dissolved aqueous phase (DAP), suspended particulate matter (SPM) and Scrobicularia plana soft tissues from the Tagus River estuary was determined to evaluate the chemicals pollution status and their hazard potential in this area. Samples were collected in 6 campaigns (December 2012–October 2013), from 3 strategical sites, and analysed via different extraction procedures followed by gas chromatography tandem mass spectrometry (GC–MS/MS) determination. The contamination profile among matrices (DAP, SPM, and soft tissue from bivalves (STB)) was marked by average concentrations of 345 ng/L, 0.51 mg/kg, and 0.02 mg/kg, respectively, with several samples above the 2013/39/EU Directive of environmental quality standards (EQS); no differences were observed between sex. A wider range of pesticides was present in STB ( n = 53) than in SPM ( n = 36) and DAP ( n = 19) matrices. Sediment–water partition coefficient, bioaccumulation factor in both DAP and SPM fraction were estimated ranging between 2.5 and 4.4 and 0.008–2799, respectively. The spatial distribution of most pesticides and physicochemical parameters were consistent, indicating a pollution pattern primarily near the Trancão River mouth. Due to the presence of the target compounds, calculated risk quotients pointed out potential hazards for aquatic organisms, mainly to invertebrates. The estimated average daily intake, theoretical maximum daily intake, and hazard quotient of the studied pesticides–via bivalve ingestion–indicated no risk for human health, although it is important to note possible biomagnification processes that may happen along the estuarine food-chain. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
21. A mollusk VDR/PXR/CAR-like (NR1J) nuclear receptor provides insight into ancient detoxification mechanisms.
- Author
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Cruzeiro, Catarina, Lopes-Marques, Mónica, Ruivo, Raquel, Rodrigues-Oliveira, Nádia, Santos, Miguel M., Rocha, Maria João, Rocha, Eduardo, and Castro, L. Filipe C.
- Subjects
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REPORTER genes , *ENDOCRINE system , *ENDOCRINE glands , *NUCLEAR receptors (Biochemistry) , *HORMONE receptors - Abstract
The origin and diversification of the metazoan endocrine systems represents a fundamental research issue in biology. Nuclear receptors are critical components of these systems. A particular group named VDR/PXR/CAR (NR1I/J) is central in the mediation of detoxification responses. While orthologues have been thoroughly characterized in vertebrates, a sparse representation is currently available for invertebrates. Here, we provide the first isolation and characterization of a lophotrochozoan protostome VDR/PXR/CAR nuclear receptor (NR1J), in the estuarine bivalve the peppery furrow shell ( Scrobicularia plana ). Using a reporter gene assay, we evaluated the xenobiotic receptor plasticity comparing the human PXR with the S. plana NR1Jβ. Our results show that the molluscan receptor responds to a natural toxin (okadaic acid) in a similar fashion to that reported for other invertebrates. In contrast, the pesticide esfenvalerate displayed a unique response, since it down regulated transactivation at higher concentrations, while for triclosan no response was observed. Additionally, we uncovered lineage specific gene duplications and gene loss in the gene group encoding NRs in protostomes with likely impacts on the complexity of detoxification mechanisms across different phyla. Our findings pave the way for the development of multi-specific sensor tools to screen xenobiotic compounds acting via the NR1I/J group. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
22. The survival, development, and reproduction of Gonipterus platensis (Coleoptera: Curculionidae) on the main Eucalyptus (Myrtaceae) genotypes planted in Brazil.
- Author
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de Oliveira NC, Ribeiro MF, Ottati A, Tavares WS, Serrão JE, Zanuncio JC, Zanetti R, and Wilcken CF
- Subjects
- Animals, Female, Brazil, Larva, Reproduction genetics, Genotype, Myrtaceae, Eucalyptus genetics, Weevils genetics, Coleoptera
- Abstract
Background: Gonipterus platensis Marelli (Coleoptera: Curculionidae) is the main defoliating beetle of Eucalyptus L'Hér. (Myrtaceae) plants worldwide. The suitability of Eucalyptus to this pest varies among host plant genotypes. The objective of this study was to evaluate the development, reproduction, and survival of G. platensis on Eucalyptus species and hybrids to assess their suitability to this insect pest in Brazil., Methods: The survival, development, and reproduction parameters were evaluated with G. platensis feeding leaves of Eucalyptus camaldulensis Dehnh., Eucalyptus grandis W. Hill., Eucalyptus urophylla S.T. Blake and on the hybrids of E. grandis × E. urophylla 'H13' and 'VR3748' in the laboratory., Results: The duration of the larval stage of G. platensis was shorter on E. urophylla. The pupal stage and the period from larva to adult were equally shorter on E. urophylla and E. camaldulensis . The viability of instars of this insect was low on both E. grandis and E. camaldulensis . The complete lifespan, oviposition period and reproduction parameters of G. platensis were greater on E. urophylla , lower on E. camaldulensis and E. grandis , and intermediate on both hybrids tested., Synthesis: Eucalyptus urophylla is the most suitable host for G. platensis survival, development, and reproduction, while E. grandis and E. camaldulensis are the least suitable., Competing Interests: Wagner de Souza Tavares is employed by Asia Pacific Resources International Holdings Ltd. (APRIL), PT. Riau Andalan Pulp and Paper (RAPP)., (©2022 Oliveira et al.)
- Published
- 2022
- Full Text
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23. Adenosine transporters and receptors: key elements for retinal function and neuroprotection.
- Author
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Dos Santos-Rodrigues A, Pereira MR, Brito R, de Oliveira NA, and Paes-de-Carvalho R
- Subjects
- Animals, Central Nervous System metabolism, Humans, Signal Transduction physiology, Adenosine metabolism, Biological Transport physiology, Central Nervous System growth & development, Neuroprotection, Nucleoside Transport Proteins metabolism, Receptors, Purinergic P1 metabolism
- Abstract
Adenosine is an important neuroactive substance in the central nervous system, including in the retina where subclasses of adenosine receptors and transporters are expressed since early stages of development. Here, we review some evidence showing that adenosine plays important functions in the mature as well as in the developing tissue. Adenosine transporters are divided into equilibrative and concentrative, and the major transporter subtype present in the retina is the ENT1. This transporter is responsible for a bidirectional transport of adenosine and the uptake or release of this nucleoside appears to be regulated by different signaling pathways that are also controlled by activation of adenosine receptors. Adenosine receptors are also key players in retina physiology regulating a variety of functions in the mature and developing tissue. Regulation of excitatory neurotransmitter release and neuroprotection are the main functions played be adenosine in the mature tissue, while regulation of cell survival and neurogenesis are some of the functions played by adenosine in developing retina. Since adenosine is neuroprotective against excitotoxic and metabolic dysfunctions observed in neurological and ocular diseases, the search for adenosine-related drugs regulating adenosine transporters and receptors can be important for advancement of therapeutic strategies against these diseases., (© 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
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