19 results on '"Pan, Yongli"'
Search Results
2. A reactive molecular dynamics simulation on the mechanism of the transformer oil pyrolysis at the high temperature
- Author
-
Wang, Huijuan, Chen, Hua, Yu, Huimin, Pan, Yongli, Sun, Yingxin, Li, Shengtao, and Han, Sheng
- Published
- 2024
- Full Text
- View/download PDF
3. A theoretical investigation on the transformer oil pyrolysis mechanism and the effect of the small molecule acid in oils
- Author
-
Wang, Huijuan, Xia, Wei, Yu, Huimin, Chen, Hua, Pan, Yongli, Sun, Yingxin, Li, Shengtao, and Han, Sheng
- Published
- 2024
- Full Text
- View/download PDF
4. Inflammation-associated D-dimer predicts neurological outcome of recent small subcortical infarct: A prospective clinical and laboratory study
- Author
-
Hao, Zhongnan, Wei, Jin, Li, Xuening, Wei, Wei, Pan, Yongli, Chen, Chuanfu, Zhu, Hongji, Xiang, Xiaofeng, Ma, Aijun, and Xin, Wenqiang
- Published
- 2024
- Full Text
- View/download PDF
5. TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury
- Author
-
Wei, Wei, Zhang, Lin, Xin, Wenqiang, Pan, Yongli, Tatenhorst, Lars, Hao, Zhongnan, Gerner, Stefan T., Huber, Sabine, Juenemann, Martin, Butz, Marius, Huttner, Hagen B., Bähr, Mathias, Fitzner, Dirk, Jia, Feng, and Doeppner, Thorsten R.
- Published
- 2024
- Full Text
- View/download PDF
6. TGF-β1 Decreases Microglia-Mediated Neuroinflammation and Lipid Droplet Accumulation in an In Vitro Stroke Model.
- Author
-
Xin, Wenqiang, Pan, Yongli, Wei, Wei, Gerner, Stefan T., Huber, Sabine, Juenemann, Martin, Butz, Marius, Bähr, Mathias, Huttner, Hagen B., and Doeppner, Thorsten R.
- Subjects
- *
TRANSFORMING growth factors , *NEUROINFLAMMATION , *LIPIDS , *RECOMBINANT proteins , *MICROGLIA , *HYPOXIA-inducible factor 1 - Abstract
Hypoxia triggers reactive microglial inflammation and lipid droplet (LD) accumulation under stroke conditions, although the mutual interactions between these two processes are insufficiently understood. Hence, the involvement of transforming growth factor (TGF)-β1 in inflammation and LD accumulation in cultured microglia exposed to hypoxia were analyzed herein. Primary microglia were exposed to oxygen-glucose deprivation (OGD) injury and lipopolysaccharide (LPS) stimulation. For analyzing the role of TGF-β1 patterns under such conditions, a TGF-β1 siRNA and an exogenous recombinant TGF-β1 protein were employed. Further studies applied Triacsin C, an inhibitor of LD formation, in order to directly assess the impact of LD formation on the modulation of inflammation. To assess mutual microglia-to-neuron interactions, a co-culture model of these cells was established. Upon OGD exposure, microglial TGF-β1 levels were significantly increased, whereas LPS stimulation yielded decreased levels. Elevating TGF-β1 expression proved highly effective in suppressing inflammation and reducing LD accumulation in microglia exposed to LPS. Conversely, inhibition of TGF-β1 led to the promotion of microglial cell inflammation and an increase in LD accumulation in microglia exposed to OGD. Employing the LD formation inhibitor Triacsin C, in turn, polarized microglia towards an anti-inflammatory phenotype. Such modulation of both microglial TGF-β1 and LD levels significantly affected the resistance of co-cultured neurons. This study provides novel insights by demonstrating that TGF-β1 plays a protective role against microglia-mediated neuroinflammation through the suppression of LD accumulation. These findings offer a fresh perspective on stroke treatment, suggesting the potential of targeting this pathway for therapeutic interventions. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
7. The regulation of PTEN: Novel insights into functions as cancer biomarkers and therapeutic targets.
- Author
-
Liu, Jie, Pan, Yongli, Liu, Yuheng, Wei, Wei, Hu, Xiaoping, Xin, Wenqiang, and Chen, Nan
- Subjects
- *
TUMOR markers , *DRUG target , *PTEN protein , *TUMOR suppressor proteins , *POST-translational modification , *PHOSPHOPROTEIN phosphatases , *PHOSPHOINOSITIDES - Abstract
This review summarizes the implications of the primary tumor suppressor protein phosphatase and tensin homolog (PTEN) in aggressive cancer development. PTEN interacts with other cellular proteins or factors suggesting the existence of an intricate molecular network that regulates their oncogenic function. Accumulating evidence has shown that PTEN exists and plays a role in the cytoplasmic organelles and in the nucleus. PTEN blocks phosphoinositide 3‐kinases (PI3K)–protein kinase B–mammalian target of rapamycin signaling pathway by dephosphorylating phosphatidylinositol (PI)‐3,4,5‐triphosphate to PI‐4,5‐bisphosphate thus counteracting PI3K function. Studies have shown that PTEN expression is tightly regulated at transcriptional, posttranscriptional, and posttranslational levels (including protein–protein interactions and posttranslational modifications). Despite recent advances in PTEN research, the regulation and function of the PTEN gene remain largely unknown. How mutation or loss of specific exons in the PTEN gene occurs and involves in cancer development is not clear. This review illustrates the regulatory mechanisms of PTEN expression and discusses how PTEN participates in tumor development and/or suppression. Future prospects for the clinical applications are also highlighted. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
8. Extracellular Vesicles as Delivery Shippers for Noncoding RNA‐Based Modulation of Angiogenesis: Insights from Ischemic Stroke and Cancer.
- Author
-
Pan, Yongli, Liu, Yuheng, Wei, Wei, Yang, Xinyu, Wang, Zengguang, and Xin, Wenqiang
- Published
- 2023
- Full Text
- View/download PDF
9. The Emerging Role of the Interaction of Extracellular Vesicle and Autophagy—Novel Insights into Neurological Disorders
- Author
-
Wei,Wei, Pan,Yongli, Yang,Xinyu, Chen,Zhonglun, Heng,Yue, Yang,Bufan, Pu,Mingjun, Zuo,Jiacai, Lai,Zhuhong, Tang,Yufeng, and Xin,Wenqiang
- Subjects
Journal of Inflammation Research - Abstract
Wei Wei,1,2,* Yongli Pan,2,3,* Xinyu Yang,4 Zhonglun Chen,1 Yue Heng,1 Bufan Yang,1 Mingjun Pu,1 Jiacai Zuo,1 Zhuhong Lai,5 Yufeng Tang,1 Wenqiang Xin2,4 1Department of Neurology, Mianyang Central Hospital, Mianyang, Sichuan, Peopleâs Republic of China; 2Department of Neurology, University Medical Center of Göttingen, Georg-August-University of Göttingen, Göttingen, Lower Saxony, Germany; 3Department of Neurology, Weifang Medical University, Weifang, Shandong, Peopleâs Republic of China; 4Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, Peopleâs Republic of China; 5Department of Cardiology, Mianyang Central Hospital, Mianyang, Sichuan, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Wenqiang Xin, Department of Neurosurgery, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin, 300052, Peopleâs Republic of China, Tel +86â 18526201182, Fax +86â 2260362062, Email xinwenqiangdr@126.com Wei Wei, Department of Neurology, Mianyang Central Hospital, Changjia Lane No. 12, Mianyang, 621000, Peopleâs Republic of China, Tel +86â 15983634286, Fax +86-8162222566, Email weiwei1990sci@163.comAbstract: Eukaryotic cells release different types of extracellular vesicles (EVs), including exosomes, apoptotic bodies and microvesicles. EVs carry proteins, lipids and nucleic acids specific to cells and cell states. Autophagy is an intracellular degradation process, which, along with EVs, can significantly affect the development and progression of neurological diseases and, therefore, has been the hotspot. Generally, EVs and autophagy are closely associated. EVs and autophagy can interact with each other. On the one hand, the level of autophagy in target cells is closely related to the secretion and transport of EVs. In another, the application of EVs provides a great opportunity for adjuvant treatment of neurological disorders, for which autophagy is an excellent target. EVs can release their cargos into target cells, which, in turn, regulate the autophagic level of target cells through autophagy-related proteins directly and the non-coding RNA, signal transducer and activator of transcription 3 (STAT3), phosphodiesterase enzyme (PDE) 1-B, etc. signaling pathways indirectly, thus regulating the development of related neurological disorders.Keywords: extracellular vesicle, autophagy, neurological disorders, non-coding RNA, STAT3, PDE1-B
- Published
- 2022
10. Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation
- Author
-
Pan,Yongli, Wang,Ting, Zhao,Zhiqiang, Wei,Wei, Yang,Xinyu, Wang,Xianbin, and Xin,Wenqiang
- Subjects
Journal of Inflammation Research - Abstract
Yongli Pan,1,2,* Ting Wang,3,* Zhiqiang Zhao,4,* Wei Wei,2,5,* Xinyu Yang,6 Xianbin Wang,7 Wenqiang Xin2,6 1Department of Neurology, Weifang Medical University, Weifang, Shandong, People’s Republic of China; 2Georg-August-University of Göttingen, Göttingen, Lower Saxony, Germany; 3Department of Radiology, The Second Affiliated Hospital of Baotou Medical College, Baotou, 014030, People’s Republic of China; 4Department of Neurosurgery, Heji Hospital affiliated Changzhi Medical College, Shanxi, People’s Republic of China; 5Department of Neurology, Mianyang Central Hospital, Mianyang, Sichuan, People’s Republic of China; 6Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 7Department of Emergency Medicine, The Second Affiliated Hospital of Baotou Medical College, Baotou, 014030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenqiang XinDepartment of Neurosurgery, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin, 300052, People’s Republic of ChinaTel +86– 18526201182, Fax +86– 2260362062, Email xinwenqiangdr@126.com Xianbin WangDepartment of Emergency Medicine, The Second Affiliated Hospital of Baotou Medical College, Baotou, 014030, People’s Republic of ChinaEmail wangxianbin198006@163.comAbstract: Nuclear paraspeckle assembly transcript 1 (Neat1) located at chromosome 11 is a long non-coding RNA that is widely expressed in mammalian cell types, and which is overexpressed in several inflammation-related disorders. Inflammation implies a plethora of mutual interactions between both soluble factors and cells due to various stimuli including tissue injury. Although there is no doubt that inflammation is critically involved in multiple biological and pathological processes alike, the precise mechanisms being involved are still open for debate. In this context, the role of Neat1 as a regulator of inflammation, microglial activation, and lipid accumulation under various inflammatory conditions remains elusive. Herein, we review the regulation of Neat1 and how it modulates the expression of its target genes. Thereafter, we will review the impact of Neat1 on inflammation by activating or inhibiting various signaling pathways, such as microRNAs, AKT, TLR4, TRAF6, and NF-κB.Keywords: Neat1, inflammation, microglia, lipids, microRNA, NF-κB
- Published
- 2022
11. Emerging Role of LncRNAs in Ischemic Stroke—Novel Insights into the Regulation of Inflammation
- Author
-
Pan,Yongli, Jiao,Qingzheng, Wei,Wei, Zheng,Tianyang, Yang,Xinyu, and Xin,Wenqiang
- Subjects
Journal of Inflammation Research - Abstract
Yongli Pan,1,* Qingzheng Jiao,2,* Wei Wei,3,* Tianyang Zheng,4,* Xinyu Yang,5 Wenqiang Xin5 1Department of Neurology, Weifang Medical University, Weifang, Shandong, Peopleâs Republic of China; 2Second Department of Internal Medicine, Gucheng County Hospital, Gucheng, Hebei, Peopleâs Republic of China; 3Department of Neurology, Mianyang Central Hospital, Mianyang, Sichuan, Peopleâs Republic of China; 4Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin, Peopleâs Republic of China; 5Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Wenqiang XinDepartment of Neurosurgery, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin, 300052, Peopleâs Republic of ChinaTel +86â 185 26201182Fax +86â 22 60362062Email xinwenqiangdr@126.comAbstract: As a crucial kind of pervasive gene, long noncoding RNAs (lncRNAs) are abundant and key players in brain function as well as numerous neurological disorders, especially ischemic stroke. The mechanisms underlying ischemic stroke include angiogenesis, autophagy, apoptosis, cell death, and neuroinflammation. Inflammation plays a vital role in the pathological process of ischemic stroke, and systemic inflammation affects the patientâs prognosis. Although a great deal of research has illustrated that various lncRNAs are closely relevant to regulate neuroinflammation and microglial activation in ischemic stroke, the specific interactional relationships and mechanisms between lncRNAs and neuroinflammation have not been described clearly. This review aimed to summarize the therapeutic effects and action mechanisms of lncRNAs on ischemia by regulating inflammation and microglial activation. In addition, we emphasize that lncRNAs have the potential to modulate inflammation by inhibiting and activating various signaling pathways, such as microRNAs, NFâκB and ERK.Keywords: ischemic stroke, long noncoding RNA, microglia, neuroinflammation
- Published
- 2021
12. A Meta-Analysis of Using Protamine for Reducing the Risk of Hemorrhage During Carotid Recanalization: Direct Comparisons of Post-operative Complications.
- Author
-
Pan, Yongli, Zhao, Zhiqiang, Yang, Tao, Jiao, Qingzheng, Wei, Wei, Ji, Jianyong, and Xin, Wenqiang
- Subjects
TRANSIENT ischemic attack ,HEMORRHAGE ,STATISTICAL software ,MYOCARDIAL infarction ,DRUG-eluting stents - Abstract
Background: Protamine can decrease the risk of hemorrhage during carotid recanalization. However, it may cause severe side effects. There is no consensus on the safety and efficacy of protamine during surgery. Thus, we conduct a comprehensive review and meta-analysis to compare the differences between the protamine and the no-protamine group. Method: We systematically obtained literature from Medline, Google Scholar, Cochrane Library, and PubMed electronic databases. All four databases were scanned from 1937 when protamine was first adopted as a heparin antagonist until February 2021. The reference lists of identified studies were manually checked to determine other eligible studies that qualify. The articles were included in this meta-analysis as long as they met the criteria of PICOS; conference or commentary articles, letters, case report or series, and animal observation were excluded from this study. The Newcastle-Ottawa Quality Assessment Scale and Cochrane Collaboration's tool are used to assess the risk of bias of each included observational study and RCT, respectively. Stata version 12.0 statistical software (StataCorp LP, College Station, Texas) was adopted as statistical software. When I
2 < 50%, we consider that the data have no obvious heterogeneity, and we conduct a meta-analysis using the fixed-effect model. Otherwise, the random-effect model was performed. Result: A total of 11 studies, consisting of 94,618 participants, are included in this study. Our analysis found that the rate of wound hematoma had a significant difference among protamine and no-protamine patients (OR = 0.268, 95% CI = 0.093 to 0.774, p = 0.015). Furthermore, the incidence of hematoma requiring re-operation (0.7%) was significantly lower than that of patients without protamine (1.8%). However, there was no significant difference in the incidence of stroke, wound hematoma with hypertension, transient ischemic attacks (TIA), myocardial infarction (MI), and death. Conclusion: Among included participants undergoing recanalization, the use of protamine is effective in reducing hematoma without increasing the risk of having other complications. Besides, more evidence-based performance is needed to supplement this opinion due to inherent limitations. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
13. The necessity or not of the addition of fusion to decompression for lumbar degenerative spondylolisthesis patients: A PRISMA compliant meta-analysis.
- Author
-
Jun Wu, Jingwei Zhang, Ting Xu, Yongli Pan, Baolong Cui, Wei Wei, Yunlong Gao, Haiguang Yu, Qingliang Huang, Xin-quan Long, Yu-fan Zhou, Wu, Jun, Zhang, Jingwei, Xu, Ting, Pan, Yongli, Cui, Baolong, Wei, Wei, Gao, Yunlong, Yu, Haiguang, and Huang, Qingliang
- Published
- 2021
- Full Text
- View/download PDF
14. FK506 Attenuated Pilocarpine-Induced Epilepsy by Reducing Inflammation in Rats.
- Author
-
Wang, Aihua, Si, Zhihua, Li, Xiaolin, Lu, Lu, Pan, Yongli, and Liu, Jinzhi
- Subjects
VASCULAR cell adhesion molecule-1 ,REACTIVE oxygen species ,PROTEIN kinase C ,EPILEPSY ,STATUS epilepticus ,CELL adhesion - Abstract
Background: The status epilepticus (SE) is accompanied by a local inflammatory response and many oxygen free radicals. FK506 is an effective immunosuppressive agent with neuroprotective and neurotrophic effects, however, whether it can inhibit the inflammatory response and attenuate epilepsy remains unclear. Objective: This study aims to clarify the effect of FK506 on inflammatory response in rats with epilepsy. Methods: A total of 180 rats were randomly and equally divided into the control group, epilepsy group, and FK506 group. The rat SE model in the epilepsy group and FK506 group was induced by lithium chloride combined with pilocarpine. In the FK506 group, FK506 was given before the injection of pilocarpine. The control group was given the same volume of saline. Then the effect of FK506 on epilepsy in rats and the changes of inflammatory factors and free radicals in hippocampus were examined using hematoxylin and eosin (HE) staining, immunohistochemistry, quantitative real-time polymerase chain reaction (qRT-PCR), and western blotting. Results: FK506 ameliorated the course of pilocarpine-induced epilepsy and the neuronal loss in the rat hippocampus after SE. FK506 reduced the increased content of nitric oxide (NO), superoxide dismutase (SOD), and malondialdehyde (MDA) in the hippocampus after SE. Besides, FK506 also significantly reduced the levels of factors involved in inflammatory response such as vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), and Protein Kinase C δ (PKCδ) that rise after epilepsy. Conclusion: FK506 ameliorated the course of pilocarpine-induced epilepsy, significantly reduced free radical content, and inhibited the expression of inflammatory factors, which provided a theoretical basis for the application of FK506 in the treatment of epilepsy. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
15. Extracellular vesicles as carriers for noncoding RNA-based regulation of macrophage/microglia polarization: an emerging candidate regulator for lung and traumatic brain injuries.
- Author
-
Chen Z, Zhang J, Pan Y, Hao Z, and Li S
- Subjects
- Humans, Microglia metabolism, Macrophages metabolism, Lung metabolism, RNA, Untranslated genetics, RNA, Untranslated metabolism, Extracellular Vesicles genetics, Extracellular Vesicles metabolism, Brain Injuries, Traumatic metabolism
- Abstract
Macrophage/microglia function as immune defense and homeostatic cells that originate from bone marrow progenitor cells. Macrophage/microglia activation is historically divided into proinflammatory M1 or anti-inflammatory M2 states based on intracellular dynamics and protein production. The polarization of macrophages/microglia involves a pivotal impact in modulating the development of inflammatory disorders, namely lung and traumatic brain injuries. Recent evidence indicates shared signaling pathways in lung and traumatic brain injuries, regulated through non-coding RNAs (ncRNAs) loaded into extracellular vesicles (EVs). This packaging protects ncRNAs from degradation. These vesicles are subcellular components released through a paracellular mechanism, constituting a group of nanoparticles that involve exosomes, microvesicles, and apoptotic bodies. EVs are characterized by a double-layered membrane and are abound with proteins, nucleic acids, and other bioactive compounds. ncRNAs are RNA molecules with functional roles, despite their absence of coding capacity. They actively participate in the regulation of mRNA expression and function through various mechanisms. Recent studies pointed out that selective packaging of ncRNAs into EVs plays a role in modulating distinct facets of macrophage/microglia polarization, under conditions of lung and traumatic brain injuries. This study will explore the latest findings regarding the role of EVs in the progression of lung and traumatic brain injuries, with a specific focus on the involvement of ncRNAs within these vesicles. The conclusion of this review will emphasize the clinical opportunities presented by EV-ncRNAs, underscoring their potential functions as both biomarkers and targets for therapeutic interventions., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Chen, Zhang, Pan, Hao and Li.)
- Published
- 2024
- Full Text
- View/download PDF
16. Preconditioned extracellular vesicles from hypoxic microglia reduce poststroke AQP4 depolarization, disturbed cerebrospinal fluid flow, astrogliosis, and neuroinflammation.
- Author
-
Xin W, Pan Y, Wei W, Tatenhorst L, Graf I, Popa-Wagner A, Gerner ST, Huber S, Kilic E, Hermann DM, Bähr M, Huttner HB, and Doeppner TR
- Subjects
- Animals, Mice, Gliosis metabolism, Hypoxia metabolism, Inflammation metabolism, Microglia metabolism, Neuroinflammatory Diseases, Oxygen metabolism, Aquaporin 4 metabolism, Brain Injuries metabolism, Extracellular Vesicles metabolism, Stroke metabolism
- Abstract
Background: Stroke stimulates reactive astrogliosis, aquaporin 4 (AQP4) depolarization and neuroinflammation. Preconditioned extracellular vesicles (EVs) from microglia exposed to hypoxia, in turn, reduce poststroke brain injury. Nevertheless, the underlying mechanisms of such effects are elusive, especially with regards to inflammation, AQP4 polarization, and cerebrospinal fluid (CSF) flow. Methods: Primary microglia and astrocytes were exposed to oxygen-glucose deprivation (OGD) injury. For analyzing the role of AQP4 expression patterns under hypoxic conditions, a co-culture model of astrocytes and microglia was established. Further studies applied a stroke model, where some mice also received an intracisternal tracer infusion of rhodamine B. As such, these in vivo studies involved the analysis of AQP4 polarization, CSF flow, astrogliosis, and neuroinflammation as well as ischemia-induced brain injury. Results: Preconditioned EVs decreased periinfarct AQP4 depolarization, brain edema, astrogliosis, and inflammation in stroke mice. Likewise, EVs promoted postischemic CSF flow and cerebral blood perfusion, and neurological recovery. Under in vitro conditions, hypoxia stimulated M2 microglia polarization, whereas EVs augmented M2 microglia polarization and repressed M1 microglia polarization even further. In line with this, astrocytes displayed upregulated AQP4 clustering and proinflammatory cytokine levels when exposed to OGD, which was reversed by preconditioned EVs. Reduced AQP4 depolarization due to EVs, however, was not a consequence of unspecific inflammatory regulation, since LPS-induced inflammation in co-culture models of astrocytes and microglia did not result in altered AQP4 expression patterns in astrocytes. Conclusions: These findings show that hypoxic microglia may participate in protecting against stroke-induced brain damage by regulating poststroke inflammation, astrogliosis, AQP4 depolarization, and CSF flow due to EV release., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)
- Published
- 2023
- Full Text
- View/download PDF
17. The necessity or not of the addition of fusion to decompression for lumbar degenerative spondylolisthesis patients: A PRISMA compliant meta-analysis.
- Author
-
Wu J, Zhang J, Xu T, Pan Y, Cui B, Wei W, Gao Y, Yu H, Huang Q, Long XQ, and Zhou YF
- Subjects
- Aged, Aged, 80 and over, Humans, Lumbar Vertebrae surgery, Middle Aged, Patient Satisfaction, Randomized Controlled Trials as Topic, Visual Analog Scale, Decompression, Surgical adverse effects, Low Back Pain surgery, Spinal Fusion adverse effects, Spondylolisthesis surgery
- Abstract
Background: The new emerging application of decompression combined with fusion comes with a concern of cost performance, however, it is a lack of big data support. We aimed to evaluate the necessity or not of the addition of fusion for decompression in patients with lumbar degenerative spondylolisthesis., Methods: Potential studies were selected from PubMed, Web of Science, and Cochrane Library, and gray relevant studies were manually searched. We set the searching time spanning from the creating date of electronic engines to August 2020. STATA version 11.0 was exerted to process the pooled data., Results: Six RCTs were included in this study. A total of 650 patients were divided into 275 in the decompression group and 375 in the fusion group. No statistic differences were found in the visual analog scales (VAS) score for low back pain (weighted mean difference [WMD], -0.045; 95% confidence interval [CI], -1.259-1.169; P = .942) and leg pain (WMD, 0.075; 95% CI, -1.201-1.35; P = .908), Oswestry Disability Index (ODI) score (WMD, 1.489; 95% CI, -7.232-10.211; P = .738), European Quality of Life-5 Dimensions (EQ-5D) score (WMD, 0.03; 95% CI, -0.05-0.12; P = .43), Odom classification (OR, 0.353; 95% CI 0.113-1.099; P = .072), postoperative complications (OR, 0.437; 95% CI, 0.065-2.949; P = .395), secondary operation (OR, 2.541; 95% CI 0.897-7.198; P = .079), and postoperative degenerative spondylolisthesis (OR = 8.59, P = .27). Subgroup analysis of VAS score on low back pain (OR = 0.77, 95% CI, 0.36-1.65; P = .50) was demonstrated as no significant difference as well., Conclusion: The overall efficacy of the decompression combined with fusion is not revealed to be superior to decompression alone. At the same time, more evidence-based performance is needed to supplement this opinion., Competing Interests: The authors have no conflicts of interest to disclose., (Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Published
- 2021
- Full Text
- View/download PDF
18. Phase Behavior and Rheological Properties of Poly(vinyl alcohol)/AES/Water System.
- Author
-
Pan Y, Dang L, and Wei H
- Abstract
In this work, the phase behavior of the poly(vinyl alcohol) (PVA)/alkyl ethoxysulfate (AES)/water ternary system is investigated at 25 °C. The PVA/AES/water ternary phase diagram is conducted which shows that there are two main phases corresponding to the solid phase and the hexagonal liquid crystalline phase (H) in the ternary system. Besides these two phases, a high-viscosity liquid phase (L
2 ) and a micellar phase (L1 ) can also be found in the phase diagram, although they just occupy small areas. Polarizing optical microscopy and small-angle X-ray scattering are used to characterize the different lyotropic liquid crystal types. Moreover, the viscosity distribution and oscillation tests are also performed by means of the rheometer. High elastic modulus ( G ') and viscous modulus ( G ″) can be found in the H and the L2 phase, whereas both moduli are low in the L1 region. The PVA/AES/water ternary phase diagram provides a good guide for accelerating the selection of the detergent formula, whereas the rheological tests provide an application guidance for industrial operations. Beyond tis, the L1 region is considered to be a reasonable range for slurry making because of its good fluidity and low viscoelasticity. This research enriches the content of polymer-surfactant aggregates and promotes the development of solid detergent manufacturing industry.- Published
- 2021
- Full Text
- View/download PDF
19. Common apolipoprotein E gene mutations contribute to lipoprotein glomerulopathy in China.
- Author
-
Han J, Pan Y, Chen Y, Li X, Xing G, Shi J, Hou P, Zhang H, and Wang H
- Subjects
- Adult, Apolipoproteins E blood, China, Female, Genetic Carrier Screening methods, Glomerulonephritis blood, Humans, Lipoproteins adverse effects, Lipoproteins blood, Lipoproteins genetics, Male, Middle Aged, Pedigree, Apolipoproteins E genetics, Asian People genetics, Glomerulonephritis genetics, Glomerulonephritis pathology, Kidney Glomerulus pathology, Mutation genetics
- Abstract
Background: Lipoprotein glomerulopathy (LPG) is a unique disease characterized by thrombus-like lipoprotein deposition in glomeruli and an increased serum apolipoprotein E level (ApoE protein or APOE gene). Several APOE mutations contribute to the occurring of LPG., Methods: We confirmed LPG in 7 individuals by renal biopsy, and investigated families of 2 patients with urinalysis, serum creatinine and serum lipid examination. Exons of APOE of all individuals as well as their relatives were amplified and sequenced directly., Results: Two types of APOE mutations were identified in the 7 patients and their relatives. APOE Maebashi (Arg142-Leu144-->0) heterozygotes were found in 5 individuals who were from 4 different families. APOE Kyoto (Arg25-Cys) was confirmed heterogeneous in another 2 individuals. Both mutations present incomplete penetrance., Conclusion: Our research indicates that APOE Maebashi (Arg142-Leu144-->0) is a common mutation in Chinese LPG. However, not all carriers of the 2 mutations have LPG, although hyperlipidemia and high serum ApoE level are tested. There are likely other reasons, such as a local mechanism in the glomeruli, which participated in the renal injury., (Copyright 2010 S. Karger AG, Basel.)
- Published
- 2010
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.