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1. Long-term Fasting Promotes Reversible Cardiometabolic Switching: An MR Spectroscopy Study

Author: Stanislas Rapacchi, PhD, Tangi Roussel, PhD, Joevin Sourdon, PhD, Hélène Ratiney, PhD, Lorena Petrusca-Perisanu, PhD, Franziska Grundler, PhD, Robin Mesnage, PhD, Françoise Wilhelmi De Toledo, MD, PhD, Pierre Croisille, MD, PhD, and Magalie Viallon, PhD
Subjects: Diseases of the circulatory (Cardiovascular) system, RC666-701
Published: 2024
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2. Ai-based Comparison of Conventional LGE & Synthetic Magir-lge with Optimal Inversion-time: Impact on Population Analysis?

Author: Romain Deleat-besson, MSc, BEng, Magalie Viallon, PhD, Lorena Petrusca-Perisanu, PhD, Pierre Croisille, MD, PhD, and Nicolas Duchateau, PhD
Subjects: Diseases of the circulatory (Cardiovascular) system, RC666-701
Published: 2024
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3. Distortion-FBee Cardiac Diffusion Tensor Imaging Using Multi-shot Echo-planar Imaging at 3T

Author: Kevin Moulin, PhD, Thomas Troalen, PhD, Pierre Croisille, MD, PhD, and Magalie Viallon, PhD
Subjects: Diseases of the circulatory (Cardiovascular) system, RC666-701
Published: 2024
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4. Prognostic value of cardiovascular magnetic resonance T1 mapping and extracellular volume fraction in nonischemic dilated cardiomyopathy

Author: Farah Cadour, Morgane Quemeneur, Loic Biere, Erwan Donal, Zakarya Bentatou, Jean-Christophe Eicher, François Roubille, Alain Lalande, Roch Giorgi, Stanislas Rapacchi, Sébastien Cortaredona, Farouk Tradi, Axel Bartoli, Serge Willoteaux, François Delahaye, Stephanie M. Biene, Lionel Mangin, Nadine Ferrier, Jean-Nicolas Dacher, Fabrice Bauer, Guillaume Leurent, Pierre-Axel Lentz, Hélène Kovacsik, Pierre Croisille, Franck Thuny, Monique Bernard, Maxime Guye, Alain Furber, Gilbert Habib, and Alexis Jacquier
Subjects: Nonischemic dilated cardiomyopathy, Cardiac magnetic resonance, Extracellular volume (ECV), Native T1, Late gadolinium enhancement, Prognostic value, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Background Heart failure- (HF) and arrhythmia-related complications are the main causes of morbidity and mortality in patients with nonischemic dilated cardiomyopathy (NIDCM). Cardiovascular magnetic resonance (CMR) imaging is a noninvasive tool for risk stratification based on fibrosis assessment. Diffuse interstitial fibrosis in NIDCM may be a limitation for fibrosis assessment through late gadolinium enhancement (LGE), which might be overcome through quantitative T1 and extracellular volume (ECV) assessment. T1 and ECV prognostic value for arrhythmia-related events remain poorly investigated. We asked whether T1 and ECV have a prognostic value in NIDCM patients. Methods This prospective multicenter study analyzed 225 patients with NIDCM confirmed by CMR who were followed up for 2 years. CMR evaluation included LGE, native T1 mapping and ECV values. The primary endpoint was the occurrence of a major adverse cardiovascular event (MACE) which was divided in two groups: HF-related events and arrhythmia-related events. Optimal cutoffs for prediction of MACE occurrence were calculated for all CMR quantitative values. Results Fifty-eight patients (26%) developed a MACE during follow-up, 42 patients (19%) with HF-related events and 16 patients (7%) arrhythmia-related events. T1 Z-score (p = 0.008) and global ECV (p = 0.001) were associated with HF-related events occurrence, in addition to left ventricular ejection fraction (p 32.1% (optimal cutoff) remained the only CMR independent predictor of HF-related events occurrence (HR 2.15 [1.14–4.07], p = 0.018). In the arrhythmia-related events group, patients had increased native T1 Z-score and ECV values, with both T1 Z-score > 4.2 and ECV > 30.5% (optimal cutoffs) being independent predictors of arrhythmia-related events occurrence (respectively, HR 2.86 [1.06–7.68], p = 0.037 and HR 2.72 [1.01–7.36], p = 0.049). Conclusions ECV was the sole independent predictive factor for both HF- and arrhythmia-related events in NIDCM patients. Native T1 was also an independent predictor in arrhythmia-related events occurrence. The addition of ECV and more importantly native T1 in the decision-making algorithm may improve arrhythmia risk stratification in NIDCM patients. Trial registration NCT02352129. Registered 2nd February 2015—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02352129
Published: 2023
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5. Therapeutic potential of extracellular vesicles derived from cardiac progenitor cells in rodent models of chemotherapy-induced cardiomyopathy

Author: Manon Desgres, Bruna Lima Correa, Lorena Petrusca, Gwennhael Autret, Chloé Pezzana, Céline Marigny, Chloé Guillas, Valérie Bellamy, José Vilar, Marie-Cécile Perier, Florent Dingli, Damarys Loew, Camille Humbert, Jérôme Larghero, Guillaume Churlaud, Nisa Renault, Pierre Croisille, Albert Hagège, Jean-Sébastien Silvestre, and Philippe Menasché
Subjects: cardiovascular progenitor, extracellular vesicles, chemotherapy-induced cardiomyopathy, cardiac strain, cardio-oncology, regenerative medicine, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: BackgroundCurrent treatments of chemotherapy-induced cardiomyopathy (CCM) are of limited efficacy. We assessed whether repeated intravenous injections of human extracellular vesicles from cardiac progenitor cells (EV-CPC) could represent a new therapeutic option and whether EV manufacturing according to a Good Manufacturing Practices (GMP)-compatible process did not impair their bioactivity.MethodsImmuno-competent mice received intra-peritoneal injections (IP) of doxorubicin (DOX) (4 mg/kg each; cumulative dose: 12 mg/kg) and were then intravenously (IV) injected three times with EV-CPC (total dose: 30 billion). Cardiac function was assessed 9–11 weeks later by cardiac magnetic resonance imaging (CMR) using strain as the primary end point. Then, immuno-competent rats received 5 IP injections of DOX (3 mg/kg each; cumulative dose 15 mg/kg) followed by 3 equal IV injections of GMP-EV (total dose: 100 billion). Cardiac function was assessed by two dimensional-echocardiography.ResultsIn the chronic mouse model of CCM, DOX + placebo-injected hearts incurred a significant decline in basal (global, epi- and endocardial) circumferential strain compared with sham DOX-untreated mice (p = 0.043, p = 0.042, p = 0.048 respectively) while EV-CPC preserved these indices. Global longitudinal strain followed a similar pattern. In the rat model, IV injections of GMP-EV also preserved left ventricular end-systolic and end-diastolic volumes compared with untreated controls.ConclusionsIntravenously-injected extracellular vesicles derived from CPC have cardio-protective effects which may make them an attractive user-friendly option for the treatment of CCM.
Published: 2023
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6. Pixel-wise statistical analysis of myocardial injury in STEMI patients with delayed enhancement MRI

Author: Nicolas Duchateau, Magalie Viallon, Lorena Petrusca, Patrick Clarysse, Nathan Mewton, Loic Belle, and Pierre Croisille
Subjects: acute myocadial infarction, delayed enhancement MRI, statistical atlas, infarct size, microvascular obstruction, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: ObjectivesMyocardial injury assessment from delayed enhancement magnetic resonance images is routinely limited to global descriptors such as size and transmurality. Statistical tools from computational anatomy can drastically improve this characterization, and refine the assessment of therapeutic procedures aiming at infarct size reduction. Based on these techniques, we propose a new characterization of myocardial injury up to the pixel resolution. We demonstrate it on the imaging data from the Minimalist Immediate Mechanical Intervention randomized clinical trial (MIMI: NCT01360242), which aimed at comparing immediate and delayed stenting in acute ST-Elevation Myocardial Infarction (STEMI) patients.MethodsWe analyzed 123 patients from the MIMI trial (62 ± 12 years, 98 male, 65 immediate 58 delayed stenting). Early and late enhancement images were transported onto a common geometry using techniques inspired by statistical atlases, allowing pixel-wise comparisons across population subgroups. A practical visualization of lesion patterns against specific clinical and therapeutic characteristics was also proposed using state-of-the-art dimensionality reduction.ResultsInfarct patterns were roughly comparable between the two treatments across the whole myocardium. Subtle but significant local differences were observed for the LCX and RCA territories with higher transmurality for delayed stenting at lateral and inferior/inferoseptal locations, respectively (15% and 23% of myocardial locations with a p-value
Published: 2023
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7. Cardioprotective effects of shock wave therapy: A cardiac magnetic resonance imaging study on acute ischemia-reperfusion injury

Author: Lorena Petrusca, Pierre Croisille, Lionel Augeul, Michel Ovize, Nathan Mewton, and Magalie Viallon
Subjects: shock wave therapy, myocardial ischemia/reperfusion injury, acute myocardial infarction, experimental studies, cardioprotection, mechano-transduction, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: IntroductionCardioprotection strategies remain a new frontier in treating acute myocardial infarction (AMI), aiming at further protect the myocardium from the ischemia-reperfusion damage. Therefore, we aimed at investigating the mechano-transduction effects induced by shock waves (SW) therapy at time of the ischemia reperfusion as a non-invasive cardioprotective innovative approach to trigger healing molecular mechanisms.MethodsWe evaluated the SW therapy effects in an open-chest pig ischemia-reperfusion (IR) model, with quantitative cardiac Magnetic Resonance (MR) imaging performed along the experiments at multiple time points (baseline (B), during ischemia (I), at early reperfusion (ER) (∼15 min), and late reperfusion (LR) (3 h)). AMI was obtained by a left anterior artery temporary occlusion (50 min) in 18 pigs (32 ± 1.9 kg) randomized into SW therapy and control groups. In the SW therapy group, treatment was started at the end of the ischemia period and extended during early reperfusion (600 + 1,200 shots @0.09 J/mm2, f = 5 Hz). The MR protocol included at all time points LV global function assessment, regional strain quantification, native T1 and T2 parametric mapping. Then, after contrast injection (gadolinium), we obtained late gadolinium imaging and extra-cellular volume (ECV) mapping. Before animal sacrifice, Evans blue dye was administrated after re-occlusion for area-at-risk sizing.ResultsDuring ischemia, LVEF decreased in both groups (25 ± 4.8% in controls (p = 0.031), 31.6 ± 3.2% in SW (p = 0.02). After reperfusion, left ventricular ejection fraction (LVEF) remained significantly decreased in controls (39.9 ± 4% at LR vs. 60 ± 5% at baseline (p = 0.02). In the SW group, LVEF increased quickly ER (43.7 ± 11.4% vs. 52.4 ± 8.2%), and further improved at LR (49.4 ± 10.1) (ER vs. LR p = 0.05), close to baseline reference (LR vs. B p = 0.92). Furthermore, there was no significant difference in myocardial relaxation time (i.e. edema) after reperfusion in the intervention group compared to the control group: ΔT1 (MI vs. remote) was increased by 23.2±% for SW vs. +25.2% for the controls, while ΔT2 (MI vs. remote) increased by +24.9% for SW vs. +21.7% for the control group.DiscussionIn conclusion, we showed in an ischemia-reperfusion open-chest swine model that SW therapy, when applied near the relief of 50′ LAD occlusion, led to a nearly immediate cardioprotective effect translating to a reduction in the acute ischemia-reperfusion lesion size and to a significant LV function improvement. These new and promising results related to the multi-targeted effects of SW therapy in IR injury need to be confirmed by further in-vivo studies in close chest models with longitudinal follow-up.
Published: 2023
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8. Reproducibility of global and segmental myocardial strain using cine DENSE at 3 T: a multicenter cardiovascular magnetic resonance study in healthy subjects and patients with heart disease

Author: Daniel A. Auger, Sona. Ghadimi, Xiaoying Cai, Claire E. Reagan, Changyu Sun, Mohamad Abdi, Jie Jane Cao, Joshua Y. Cheng, Nora Ngai, Andrew D. Scott, Pedro F. Ferreira, John N. Oshinski, Nick Emamifar, Daniel B. Ennis, Michael Loecher, Zhan-Qiu Liu, Pierre Croisille, Magalie Viallon, Kenneth C. Bilchick, and Frederick H. Epstein
Subjects: DENSE, CMR, Myocardial strain imaging, Reproducibility, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Background While multiple cardiovascular magnetic resonance (CMR) methods provide excellent reproducibility of global circumferential and global longitudinal strain, achieving highly reproducible segmental strain is more challenging. Previous single-center studies have demonstrated excellent reproducibility of displacement encoding with stimulated echoes (DENSE) segmental circumferential strain. The present study evaluated the reproducibility of DENSE for measurement of whole-slice or global circumferential (Ecc), longitudinal (Ell) and radial (Err) strain, torsion, and segmental Ecc at multiple centers. Methods Six centers participated and a total of 81 subjects were studied, including 60 healthy subjects and 21 patients with various types of heart disease. CMR utilized 3 T scanners, and cine DENSE images were acquired in three short-axis planes and in the four-chamber long-axis view. During one imaging session, each subject underwent two separate DENSE scans to assess inter-scan reproducibility. Each subject was taken out of the scanner and repositioned between the scans. Intra-user, inter-user-same-site, inter-user-different-site, and inter-user-Human-Deep-Learning (DL) comparisons assessed the reproducibility of different users analyzing the same data. Inter-scan comparisons assessed the reproducibility of DENSE from scan to scan. The reproducibility of whole-slice or global Ecc, Ell and Err, torsion, and segmental Ecc were quantified using Bland–Altman analysis, the coefficient of variation (CV), and the intraclass correlation coefficient (ICC). CV was considered excellent for CV ≤ 10%, good for 10% 40. ICC values were considered excellent for ICC > 0.74, good for ICC 0.6
Published: 2022
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9. Long-term fasting: Multi-system adaptations in humans (GENESIS) study–A single-arm interventional trial

Author: Franziska Grundler, Magalie Viallon, Robin Mesnage, Massimiliano Ruscica, Clemens von Schacky, Frank Madeo, Sebastian J. Hofer, Sarah J. Mitchell, Pierre Croisille, and Françoise Wilhelmi de Toledo
Subjects: organ size, lipoprotein metabolism, metabolomics, microbiome, long-term fasting, magnetic resonance imaging (MRI), Nutrition. Foods and food supply, TX341-641
Abstract: Fasting provokes fundamental changes in the activation of metabolic and signaling pathways leading to longer and healthier lifespans in animal models. Although the involvement of different metabolites in fueling human fasting metabolism is well known, the contribution of tissues and organs to their supply remains partly unclear. Also, changes in organ volume and composition remain relatively unexplored. Thus, processes involved in remodeling tissues during fasting and food reintroduction need to be better understood. Therefore, this study will apply state-of-the-art techniques to investigate the effects of long-term fasting (LF) and food reintroduction in humans by a multi-systemic approach focusing on changes in body composition, organ and tissue volume, lipid transport and storage, sources of protein utilization, blood metabolites, and gut microbiome profiles in a single cohort. This is a prospective, single-arm, monocentric trial. One hundred subjects will be recruited and undergo 9 ± 3 day-long fasting periods (250 kcal/day). We will assess changes in the composition of organs, bones and blood lipid profiles before and after fasting, as well as high-density lipoprotein (HDL) transport and storage, untargeted metabolomics of peripheral blood mononuclear cells (PBMCs), protein persulfidation and shotgun metagenomics of the gut microbiome. The first 32 subjects, fasting for 12 days, will be examined in more detail by magnetic resonance imaging (MRI) and spectroscopy to provide quantitative information on changes in organ volume and function, followed by an additional follow-up examination after 1 and 4 months. The study protocol was approved by the ethics board of the State Medical Chamber of Baden-Württemberg on 26.07.2021 and registered at ClinicalTrials.gov (NCT05031598). The results will be disseminated through peer-reviewed publications, international conferences and social media.Clinical trial registration[ClinicalTrials.gov], identifier [NCT05031598].
Published: 2022
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10. Kinetics of Cardiac Remodeling and Fibrosis Biomarkers During an Extreme Mountain Ultramarathon

Author: Caroline Le Goff, Magalie Viallon, Jean-François Kaux, Pierre Andonian, Kevin Moulin, Laurence Seidel, Guido Giardini, Laurent Gergelé, Pierre Croisille, Etienne Cavalier, and Gregoire P. Millet
Subjects: cardiac biomarker, cardiac fibrosis markers, ultramarathon running, ST2, galectin-3, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: ObjectivesThe effects of ultra-distance on cardiac remodeling and fibrosis are unclear. Moreover, there are no data reporting the kinetics of cardiac alterations throughout the event and during recovery. Our aim was to investigate the kinetics of biological markers including new cardiac fibrosis biomarkers suppression of tumorigenicity 2 (ST2) and galectin-3 (Gal-3) during and after an extreme mountain ultramarathon.MethodsFifty experienced runners participating in one of the most challenging mountain ultramarathons (330 km, D+ 25,000 m) were enrolled in our study. Blood samples were collected at four time points: before (Pre-), at 148 km (Mid-), at the finish line (Post-), and 3 days after the recovery period (Recov-).ResultsThe cardiac fibrosis biomarkers (ST2 and Gal-3) increased from Pre- to Mid-. During the second half, ST2 remained higher than pre-values as opposed to Gal-3. Necrosis, ischemia, and myocyte injury biomarkers increased until Mid- then decreased but remained higher at Recov- than Pre-values. Oxidative stress appeared at Mid-. Lipid peroxides remained higher at Recov- compared to Pre-. The maximal value in most of these biomarkers was observed at Mid- and not at Post-.ConclusionsThe present study supports biphasic kinetics of cardiac fibrosis biomarkers, with a relative recovery during the second half of the event that seems specific to this extreme event. Overall, performing at such an extreme ultramarathon seems less deleterious for the heart than shorter events.
Published: 2022
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11. CMRSegTools: An open-source software enabling reproducible research in segmentation of acute myocardial infarct in CMR images.

Author: William A Romero R, Magalie Viallon, Joël Spaltenstein, Lorena Petrusca, Olivier Bernard, Loïc Belle, Patrick Clarysse, and Pierre Croisille
Subjects: Medicine, Science
Abstract: In the last decade, a large number of clinical trials have been deployed using Cardiac Magnetic Resonance (CMR) to evaluate cardioprotective strategies aiming at reducing the irreversible myocardial damage at the time of reperfusion. In these studies, segmentation and quantification of myocardial infarct lesion are often performed with a commercial software or an in-house closed-source code development thus creating a barrier for reproducible research. This paper introduces CMRSegTools: an open-source application software designed for the segmentation and quantification of myocardial infarct lesion enabling full access to state-of-the-art segmentation methods and parameters, easy integration of new algorithms and standardised results sharing. This post-processing tool has been implemented as a plug-in for the OsiriX/Horos DICOM viewer leveraging its database management functionalities and user interaction features to provide a bespoke tool for the analysis of cardiac MR images on large clinical cohorts. CMRSegTools includes, among others, user-assisted segmentation of the left-ventricle, semi- and automatic lesion segmentation methods, advanced statistical analysis and visualisation based on the American Heart Association 17-segment model. New segmentation methods can be integrated into the plug-in by developing components based on image processing and visualisation libraries such as ITK and VTK in C++ programming language. CMRSegTools allows the creation of training and testing data sets (labeled features such as lesion, microvascular obstruction and remote ROI) for supervised Machine Learning methods, and enables the comparative assessment of lesion segmentation methods via a single and integrated platform. The plug-in has been successfully used by several CMR imaging studies.
Published: 2022
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12. T 1 mapping performance and measurement repeatability: results from the multi-national T 1 mapping standardization phantom program (T1MES)

Author: Gabriella Captur, Abhiyan Bhandari, Rüdiger Brühl, Bernd Ittermann, Kathryn E. Keenan, Ye Yang, Richard J. Eames, Giulia Benedetti, Camilla Torlasco, Lewis Ricketts, Redha Boubertakh, Nasri Fatih, John P. Greenwood, Leonie E. M. Paulis, Chris B. Lawton, Chiara Bucciarelli-Ducci, Hildo J. Lamb, Richard Steeds, Steve W. Leung, Colin Berry, Sinitsyn Valentin, Andrew Flett, Charlotte de Lange, Francesco DeCobelli, Magalie Viallon, Pierre Croisille, David M. Higgins, Andreas Greiser, Wenjie Pang, Christian Hamilton-Craig, Wendy E. Strugnell, Tom Dresselaers, Andrea Barison, Dana Dawson, Andrew J. Taylor, François-Pierre Mongeon, Sven Plein, Daniel Messroghli, Mouaz Al-Mallah, Stuart M. Grieve, Massimo Lombardi, Jihye Jang, Michael Salerno, Nish Chaturvedi, Peter Kellman, David A. Bluemke, Reza Nezafat, Peter Gatehouse, James C. Moon, and on behalf of the T1MES Consortium
Subjects: T 1 mapping, Standardization, Calibration, Phantom, Repeatability, Extracellular volume, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Background The T 1 Mapping and Extracellular volume (ECV) Standardization (T1MES) program explored T 1 mapping quality assurance using a purpose-developed phantom with Food and Drug Administration (FDA) and Conformité Européenne (CE) regulatory clearance. We report T 1 measurement repeatability across centers describing sequence, magnet, and vendor performance. Methods Phantoms batch-manufactured in August 2015 underwent 2 years of structural imaging, B 0 and B 1, and “reference” slow T 1 testing. Temperature dependency was evaluated by the United States National Institute of Standards and Technology and by the German Physikalisch-Technische Bundesanstalt. Center-specific T 1 mapping repeatability (maximum one scan per week to minimum one per quarter year) was assessed over mean 358 (maximum 1161) days on 34 1.5 T and 22 3 T magnets using multiple T 1 mapping sequences. Image and temperature data were analyzed semi-automatically. Repeatability of serial T 1 was evaluated in terms of coefficient of variation (CoV), and linear mixed models were constructed to study the interplay of some of the known sources of T 1 variation. Results Over 2 years, phantom gel integrity remained intact (no rips/tears), B 0 and B 1 homogenous, and “reference” T 1 stable compared to baseline (% change at 1.5 T, 1.95 ± 1.39%; 3 T, 2.22 ± 1.44%). Per degrees Celsius, 1.5 T, T 1 (MOLLI 5s(3s)3s) increased by 11.4 ms in long native blood tubes and decreased by 1.2 ms in short post-contrast myocardium tubes. Agreement of estimated T 1 times with “reference” T 1 was similar across Siemens and Philips CMR systems at both field strengths (adjusted R 2 ranges for both field strengths, 0.99–1.00). Over 1 year, many 1.5 T and 3 T sequences/magnets were repeatable with mean CoVs
Published: 2020
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13. Direct Comparison of Bayesian and Fermi Deconvolution Approaches for Myocardial Blood Flow Quantification: In silico and Clinical Validations

Author: Clément Daviller, Timothé Boutelier, Shivraman Giri, Hélène Ratiney, Marie-Pierre Jolly, Jean-Paul Vallée, Pierre Croisille, and Magalie Viallon
Subjects: myocardial perfusion quantification, cardiovascular magnetic resonance, Bayesian, perfusion-weighted imaging, heart disease, ischemic lesion, Physiology, QP1-981
Abstract: Cardiac magnetic resonance myocardial perfusion imaging can detect coronary artery disease and is an alternative to single-photon emission computed tomography or positron emission tomography. However, the complex, non-linear MR signal and the lack of robust quantification of myocardial blood flow have hindered its widespread clinical application thus far. Recently, a new Bayesian approach was developed for brain imaging and evaluation of perfusion indexes (Kudo et al., 2014). In addition to providing accurate perfusion measurements, this probabilistic approach appears more robust than previous approaches, particularly due to its insensitivity to bolus arrival delays. We assessed the performance of this approach against a well-known and commonly deployed model-independent method based on the Fermi function for cardiac magnetic resonance myocardial perfusion imaging. The methods were first evaluated for accuracy and precision using a digital phantom to test them against the ground truth; next, they were applied in a group of coronary artery disease patients. The Bayesian method can be considered an appropriate model-independent method with which to estimate myocardial blood flow and delays. The digital phantom comprised a set of synthetic time-concentration curve combinations generated with a 2-compartment exchange model and a realistic combination of perfusion indexes, arterial input dynamics, noise and delays collected from the clinical dataset. The myocardial blood flow values estimated with the two methods showed an excellent correlation coefficient (r2 > 0.9) under all noise and delay conditions. The Bayesian approach showed excellent robustness to bolus arrival delays, with a similar performance to Fermi modeling when delays were considered. Delays were better estimated with the Bayesian approach than with Fermi modeling. An in vivo analysis of coronary artery disease patients revealed that the Bayesian approach had an excellent ability to distinguish between abnormal and normal myocardium. The Bayesian approach was able to discriminate not only flows but also delays with increased sensitivity by offering a clearly enlarged range of distribution for the physiologic parameters.
Published: 2021
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14. Association of myocardial hemorrhage and persistent microvascular obstruction with circulating inflammatory biomarkers in STEMI patients.

Author: Thomas Bochaton, Jules Lassus, Alexandre Paccalet, François Derimay, Gilles Rioufol, Cyril Prieur, Eric Bonnefoy-Cudraz, Claire Crola Da Silva, Hugo Bernelin, Camille Amaz, Sylvie Espanet, Charles de Bourguignon, Nathalie Dufay, Régine Cartier, Pierre Croisille, Michel Ovize, and Nathan Mewton
Subjects: Medicine, Science
Abstract: IntroductionMyocardial hemorrhage (IMH) and persistent microvascular obstruction (MVO) are associated with impaired myocardial recovery and adverse clinical outcomes in STEMI patients. However, their relationship with circulating inflammatory biomarkers is unclear in human patients.Methods and resultsTwenty consecutive patients referred for primary percutaneous coronary intervention of first STEMI were included in a prospective study. Blood sampling was performed at admission, 4, 12, 24, 48 hours, 7 and 30 days after reperfusion for inflammatory biomarker (C reactive protein, fibrinogen, interleukin-6 (IL-6) and neutrophils count) assessment. At seven days, cardiovascular magnetic resonance (CMR) was performed for infarct size, MVO and IMH assessment. Median infarct size was 24.6% Interquartile range (IQR) [12.0-43.5] of LV mass and edema was 13.2% IQR [7.7-36.1] of LV mass. IL-6 reached a peak at H24 (5.6 pg/mL interquartile range (IQR) [2.5-17.5]), CRP at H48 (11.7 mg/L IQR [7.1-69.2]), fibrinogen one week after admission (4.4 g/L IQR [3.8-6.7]) and neutrophils at H12 (9.0 G/L IQR [6.5-12.7]). MVO was present in 11 patients (55% of the study population) and hemorrhage in 7 patients (35%). Patients with IMH had significantly higher IL-6, CRP, fibrinogen, and neutrophils levels compared to patients without IMH. Patients with persistent MVO had significantly higher CRP, fibrinogen and neutrophils level compared to patients without MVO, but identical IL-6 kinetics.ConclusionIn human patients with acute myocardial infarction, intramyocardial hemorrhage appears to have a stronger relationship with inflammatory biomarker release compared to persistent MVO. Attenuating myocardial hemorrhage may be a novel target in future adjunctive STEMI treatments.
Published: 2021
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15. Chemical-Shift-Encoded Magnetic Resonance Imaging and Spectroscopy to Reveal Immediate and Long-Term Multi-Organs Composition Changes of a 14-Days Periodic Fasting Intervention: A Technological and Case Report

Author: Magalie Viallon, Benjamin Leporq, Stephan Drinda, Françoise Wilhelmi de Toledo, Bogdan Galusca, Helene Ratiney, and Pierre Croisille
Subjects: fasting, quantitative imaging, MRI, spectroscopy, chemical shift encoded MRI, quantitative image analysis (QIA), Nutrition. Foods and food supply, TX341-641
Abstract: Objectives: The aim of this study was to investigate the feasibility of measuring the effects of a 14-day Periodic Fasting (PF) intervention (
Published: 2019
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16. Quantification of Right and Left Ventricular Function in Cardiac MR Imaging: Comparison of Semiautomatic and Manual Segmentation Algorithms

Author: Jose Martin Carreira, Pablo G. Tahoces, Amparo Martínez, Jorge Juan Suárez-Cuenca, Miguel Couto, Lambert Raul Masip, Miguel Souto, and Pierre Croisille
Subjects: cardiac cine magnetic resonance imaging (MRI), segmentation, ejection fraction (EF), right ventricular function, left ventricular function, Medicine (General), R5-920
Abstract: The purpose of this study was to evaluate the performance of a semiautomatic segmentation method for the anatomical and functional assessment of both ventricles from cardiac cine magnetic resonance (MR) examinations, reducing user interaction to a “mouse-click”. Fifty-two patients with cardiovascular diseases were examined using a 1.5-T MR imaging unit. Several parameters of both ventricles, such as end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fraction (EF), were quantified by an experienced operator using the conventional method based on manually-defined contours, as the standard of reference; and a novel semiautomatic segmentation method based on edge detection, iterative thresholding and region growing techniques, for evaluation purposes. No statistically significant differences were found between the two measurement values obtained for each parameter (p > 0.05). Correlation to estimate right ventricular function was good (r > 0.8) and turned out to be excellent (r > 0.9) for the left ventricle (LV). Bland-Altman plots revealed acceptable limits of agreement between the two methods (95%). Our study findings indicate that the proposed technique allows a fast and accurate assessment of both ventricles. However, further improvements are needed to equal results achieved for the right ventricle (RV) using the conventional methodology.
Published: 2013
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17. Shear-Wave Elastography Assessments of Quadriceps Stiffness Changes prior to, during and after Prolonged Exercise: A Longitudinal Study during an Extreme Mountain Ultra-Marathon.

Author: Pierre Andonian, Magalie Viallon, Caroline Le Goff, Charles de Bourguignon, Charline Tourel, Jérome Morel, Guido Giardini, Laurent Gergelé, Grégoire P Millet, and Pierre Croisille
Subjects: Medicine, Science
Abstract: In sports medicine, there is increasing interest in quantifying the elastic properties of skeletal muscle, especially during extreme muscular stimulation, to improve our understanding of the impact of alterations in skeletal muscle stiffness on resulting pain or injuries, as well as the mechanisms underlying the relationships between these parameters. Our main objective was to determine whether real-time shear-wave elastography (SWE) can monitor changes in quadriceps muscle elasticity during an extreme mountain ultra-marathon, a powerful mechanical stress model. Our study involved 50 volunteers participating in an extreme mountain marathon (distance: 330 km, elevation: +24,000 m). Quantitative SWE velocity and shear modulus measurements were performed in most superficial quadriceps muscle heads at the following 4 time points: before the race, halfway through the race, upon finishing the race and after recovery (+48 h). Blood biomarker levels were also measured. A significant decrease in the quadriceps shear modulus was observed upon finishing the race (3.31±0.61 kPa) (p
Published: 2016
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18. Correction: Shear-Wave Elastography Assessments of Quadriceps Stiffness Changes prior to, during and after Prolonged Exercise: A Longitudinal Study during an Extreme Mountain Ultra-Marathon.

Author: Pierre Andonian, Magalie Viallon, Caroline Le Goff, Charles de Bourguignon, Charline Tourel, Jérome Morel, Guido Giardini, Laurent Gergelé, Grégoire P Millet, and Pierre Croisille
Subjects: Medicine, Science
Abstract: [This corrects the article DOI: 10.1371/journal.pone.0161855.].
Published: 2016
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19. Reliability of standardized ultrasound measurements of quadriceps muscle thickness in neurological critically ill patients: a comparison to computed tomography measures.

Author: Charline Tourel, Laetitia Burnol, Julien Lanoiselé, Serge Molliex, Magalie Viallon, Pierre Croisille, and Jerome Morel
Subjects: critical illness, muscle wasting, muscle atrophy, quadriceps muscle, ultrasonography, computed tomography scan., Therapeutics. Pharmacology, RM1-950
Abstract: Objective: Muscle atrophy is frequent in critically ill patients and is associated with increased mortality and long-lasting alteration in quality of life. Muscle ultrasound has not been clearly validated in intensive care unit patients. The aim of this study was to compare the level of agreement between ultrasound and computed tomography scan for the measurement of quadriceps muscle thickness. Design: A prospective observational study. Patients: Forty-two consecutive patients admitted to a neurological intensive care unit. Methods: Quadriceps thickness was measured 15 cm above the upper edge of the patella. Iterative brain computed tomography scans were associated with a quadriceps-centred acquisition sequence. Concomitantly, an ultrasound of the quadriceps was performed. The position of the studied leg was standardized for ultrasound and computed tomography. Results: A total of 73 measurements of ultrasound and computed tomography quadriceps thickness were compared. The correlation between both measures was 0.93 (95% confidence interval (95% CI) 0.84–1.02). Intra-rater reliability of ultrasound measurements and inter-rater reliability were excellent, with an ICC of 0.98 (95% CI 0.97–0.99) and 0.96 (95% CI 0.92–0.98), respectively. Conclusion: A specific ultrasound set-up for measurement of quadriceps thickness is reliable and reproducible in an intensive care unit population.
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20. In vivo cardiac diffusion imaging without motion-compensation leads to unreasonably high diffusivity

Author: Kevin Moulin, Christian T. Stoeck, Leon Axel, Jordi Broncano, Pierre Croisille, Erica Dall'Armellina, Daniel B. Ennis, Pedro F. Ferreira, Alexander Gotschy, Santiago Miro, Jurgen E. Schneider, Andrew D. Scott, David E. Sosnovik, Irvin Teh, Cyril Tous, Elizabeth M. Tunnicliffe, Magalie Viallon, and Christopher Nguyen
Subjects: Radiology, Nuclear Medicine and imaging
Published: 2023

21. Disentangled representations: towards interpretation of sex determination from hip bone

Author: Kaifeng Zou, Sylvain Faisan, Fabrice Heitz, Marie Epain, Pierre Croisille, Laurent Fanton, Sébastien Valette, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), ANR-19-CE45-0015,TOPACS,Traitement Ouvert de données PACS(2019), Hospices Civils de Lyon (HCL), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Modeling & analysis for medical imaging and Diagnosis (MYRIAD), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Imagerie Tomographique et Radiothérapie
Subjects: FOS: Computer and information sciences, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Computer Vision and Pattern Recognition (cs.CV), [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Computer Science - Computer Vision and Pattern Recognition, Neural Network, Pattern recognition and classification, Computer Vision and Pattern Recognition, Bone, Computer Graphics and Computer-Aided Design, Pattern recognition and classification Shape analysis Neural Network Bone, Software, Shape analysis
Abstract: By highlighting the regions of the input image that contribute the most to the decision, saliency maps have become a popular method to make neural networks interpretable. In medical imaging, they are particularly well-suited to explain neural networks in the context of abnormality localization. However, from our experiments, they are less suited to classification problems where the features that allow to distinguish between the different classes are spatially correlated, scattered and definitely non-trivial. In this paper we thus propose a new paradigm for better interpretability. To this end we provide the user with relevant and easily interpretable information so that he can form his own opinion. We use Disentangled Variational Auto-Encoders which latent representation is divided into two components: the non-interpretable part and the disentangled part. The latter accounts for the categorical variables explicitly representing the different classes of interest. In addition to providing the class of a given input sample, such a model offers the possibility to transform the sample from a given class to a sample of another class, by modifying the value of the categorical variables in the latent representation. This paves the way to easier interpretation of class differences. We illustrate the relevance of this approach in the context of automatic sex determination from hip bones in forensic medicine. The features encoded by the model, that distinguish the different classes were found to be consistent with expert knowledge.
Published: 2023

22. Regional myocardial function at preclinical disease stage of hypertrophic cardiomyopathy in female gene variant carriers

Author: Tjeerd Germans, Celine Seegers, Albert C. van Rossum, Pierre Croisille, Patrick Clarysse, Jolanda van der Velden, Rahana Y. Parbhudayal, Cardiology, ACS - Heart failure & arrhythmias, Physiology, Modeling & analysis for medical imaging and Diagnosis (MYRIAD), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE)
Subjects: Male, Cardiac function curve, medicine.medical_specialty, TNNT2, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Diastole, Magnetic Resonance Imaging, Cine, 030204 cardiovascular system & hematology, Asymptomatic, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, MYBPC3, MYH7, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Cardiac imaging, Original Paper, medicine.diagnostic_test, business.industry, Myocardium, Hypertrophic cardiomyopathy, Heart, Tissue tagging, Magnetic resonance imaging, Cardiomyopathy, Hypertrophic, medicine.disease, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract: We recently showed more severe diastolic dysfunction at the time of myectomy in female compared to male patients with obstructive hypertrophic cardiomyopathy. Early recognition of aberrant cardiac contracility using cardiovascular magnetic resonance (CMR) imaging may identify women at risk of cardiac dysfunction. To define myocardial function at an early disease stage, we studied regional cardiac function using CMR imaging with tissue tagging in asymptomatic female gene variant carriers. CMR imaging with tissue tagging was done in 13 MYBPC3, 11 MYH7 and 6 TNNT2 gene carriers and 16 age-matched controls. Regional peak circumferential strain was derived from tissue tagging images of the basal and midventricular segments of the septum and lateral wall. Left ventricular wall thickness and global function were comparable between MYBPC3, MYH7, TNNT2 carriers and controls. MYH7 gene variant carriers showed a different strain pattern as compared to the other groups, with higher septal peak circumferential strain at the basal segments compared to the lateral wall, whereas MYBPC3, TNNT2 carriers and controls showed higher strain at the lateral wall compared to the septum. Only subtle gene-specific changes in strain pattern occur in the myocardium preceding development of cardiac hypertrophy. Overall, our study shows that there are no major contractile deficits in asymptomatic females carrying a pathogenic gene variant, which would justify the use of CMR imaging for earlier diagnosis.
Published: 2021

23. Validation of cardiac diffusion tensor imaging sequences: A multi-centre test-retest phantom study

Author: Irvin Teh, William A. Romero R., Jordan Boyle, Jaume Coll‐Font, Erica Dall'Armellina, Daniel B. Ennis, Pedro F. Ferreira, Prateek Kalra, Arunark Kolipaka, Sebastian Kozerke, David Lohr, François‐Pierre Mongeon, Kévin Moulin, Christopher Nguyen, Sonia Nielles‐Vallespin, Brian Raterman, Laura M. Schreiber, Andrew D. Scott, David E. Sosnovik, Christian T. Stoeck, Cyril Tous, Elizabeth M. Tunnicliffe, Andreas M. Weng, Pierre Croisille, Magalie Viallon, Jürgen E. Schneider, British Heart Foundation, Leeds Institute of Cardiovascular and Metabolic Medicine, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), School of Mechanical Engineering, University of Leeds, Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School [Boston] (HMS)-Massachusetts General Hospital [Boston], VA Palo Alto Health Care System, Stanford University, Cardiovascular Magnetic Resonance Unit, The Royal Brompton and Harefield NHS Foundation Trust, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Wexner Medical Center, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Comprehensive Heart Failure Center, Julius-Maximilians-Universität Würzburg (JMU)-University Hospital of Würzburg-Rudolf Virchow Center for Experimental Biomedicine, Julius-Maximilians-Universität Würzburg (JMU), Division of Non-invasive Cardiology, Montreal Heart Institute - Institut de Cardiologie de Montréal, Institute of Biomedical Engineering, Université de Montréal (UdeM), Radcliffe Department of Medicine [Oxford], University of Oxford, Oxford NIHR Biomedical Research Centre, Department of Diagnostic and Interventional Radiology, University Hospital of Würzburg, RMN et optique : De la mesure au biomarqueur, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Rayet, Béatrice
Subjects: Technology, Cardiac DTI, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, multicentre, Biophysics, polyvinylpyrrolidone, SPIN ECHOES, pulse sequence validation, NOISE, DISARRAY, 0903 Biomedical Engineering, REPRODUCIBILITY, WATER, Radiology, Nuclear Medicine and imaging, Spectroscopy, Science & Technology, HYPERTROPHIC CARDIOMYOPATHY, 0304 Medicinal and Biomolecular Chemistry, Phantoms, Imaging, Radiology, Nuclear Medicine & Medical Imaging, isotropic phantom, Reproducibility of Results, Heart, 1103 Clinical Sciences, HUMAN HEART, TIME, Nuclear Medicine & Medical Imaging, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Diffusion Tensor Imaging, Molecular Medicine, Anisotropy, multi-centre, Life Sciences & Biomedicine, MRI
Abstract: International audience; Cardiac diffusion tensor imaging (DTI) is an emerging technique for the in vivo characterisation of myocardial microstructure, and there is a growing need for its validation and standardisation. We sought to establish the accuracy, precision, repeatability and reproducibility of state-of-the-art pulse sequences for cardiac DTI among 10 centres internationally. Phantoms comprising 0%-20% polyvinylpyrrolidone (PVP) were scanned with DTI using a product pulsed gradient spin echo (PGSE; N = 10 sites) sequence, and a custom motion-compensated spin echo (SE; N = 5) or stimulated echo acquisition mode (STEAM; N = 5) sequence suitable for cardiac DTI in vivo. A second identical scan was performed 1-9 days later, and the data were analysed centrally. The average mean diffusivities (MDs) in 0% PVP were (1.124, 1.130, 1.113) x 10-3 mm2 /s for PGSE, SE and STEAM, respectively, and accurate to within 1.5% of reference data from the literature. The coefficients of variation in MDs across sites were 2.6%, 3.1% and 2.1% for PGSE, SE and STEAM, respectively, and were similar to previous studies using only PGSE. Reproducibility in MD was excellent, with mean differences in PGSE, SE and STEAM of (0.3 ± 2.3, 0.24 ± 0.95, 0.52 ± 0.58) x 10-5 mm2 /s (mean ± 1.96 SD). We show that custom sequences for cardiac DTI provide accurate, precise, repeatable and reproducible measurements. Further work in anisotropic and/or deforming phantoms is warranted.
Published: 2022

24. Effect of Colchicine on Myocardial Injury in Acute Myocardial Infarction

Author: Benjamin Alos, Mariama Akodad, Olivier Dubreuil, Didier Bresson, Gilles Rioufol, Cyril Prieur, Charles De Bourguignon, Florent Boutitie, François Derimay, Loïc Bière, Gérard Finet, Rachel Daw, Ahmad Hayek, Fabrice Prunier, Pierre Croisille, Carole Dhelens, Naoual El Jonhy, Nathan Mewton, Eric Bonnefoy-Cudraz, Gabriel Bidaux, Delphine Maucort-Boulch, Claire Bouleti, Denis Angoulvant, Fabrice Ivanes, Lamis Haider, François Roubille, Thomas Bochaton, Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Centre hospitalier universitaire de Poitiers (CHU Poitiers), EA4245 - Transplantation, Immunologie, Inflammation [Tours] (T2i), Université de Tours (UT), MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-16-RHUS-0009,MARVELOUS,MARVELOUS(2016), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, medicine.medical_specialty, Heart Injury, [SDV]Life Sciences [q-bio], Contrast Media, Inflammation, 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Physiology (medical), Internal medicine, Original Research Articles, medicine, Colchicine, Humans, 030212 general & internal medicine, Myocardial infarction, Ventricular remodeling, Referral and Consultation, ComputingMilieux_MISCELLANEOUS, Aged, Ventricular Remodeling, business.industry, Myocardium, Heart, Heart injuries, Thrombosis, Middle Aged, medicine.disease, 3. Good health, Hospitalization, Clinical trial, chemistry, Ventriculat remodeling, Acute Disease, Cardiology, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ST Elevation Myocardial Infarction, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: Supplemental Digital Content is available in the text., Background: Inflammation is a key factor of myocardial damage in reperfused ST-segment–elevation myocardial infarction. We hypothesized that colchicine, a potent anti-inflammatory agent, may reduce infarct size (IS) and left ventricular (LV) remodeling at the acute phase of ST-segment–elevation myocardial infarction. Methods: In this double-blind multicenter trial, we randomly assigned patients admitted for a first episode of ST-segment–elevation myocardial infarction referred for primary percutaneous coronary intervention to receive oral colchicine (2-mg loading dose followed by 0.5 mg twice a day) or matching placebo from admission to day 5. The primary efficacy outcome was IS determined by cardiac magnetic resonance imaging at 5 days. The relative LV end-diastolic volume change at 3 months and IS at 3 months assessed by cardiac magnetic resonance imaging were among the secondary outcomes. Results: We enrolled 192 patients, 101 in the colchicine group and 91 in the control group. At 5 days, the gadolinium enhancement–defined IS did not differ between the colchicine and placebo groups with a mean of 26 interquartile range (IQR) [16–44] versus 28.4 IQR [14–40] g of LV mass, respectively (P=0.87). At 3 months follow-up, there was no significant difference in LV remodeling between the colchicine and placebo groups with a +2.4% (IQR, –8.3% to 11.1%) versus –1.1% (IQR, –8.0% to 9.9%) change in LV end-diastolic volume (P=0.49). Infarct size at 3 months was also not significantly different between the colchicine and placebo groups (17 IQR [10–28] versus 18 IQR [10–27] g of LV mass, respectively; P=0.92). The incidence of gastrointestinal adverse events during the treatment period was greater with colchicine than with placebo (34% versus 11%, respectively; P=0.0002). Conclusions: In this randomized, placebo-controlled trial, oral administration of high-dose colchicine at the time of reperfusion and for 5 days did not reduce IS assessed by cardiac magnetic resonance imaging. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03156816.
Published: 2021

25. Time-Dependent Two-Dimensional Fourth-Order Problems: Optimal Convergence

Author: Jean-Pierre Croisille, Dalia Fishelov, Institut Élie Cartan de Lorraine (IECL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and AFEKA: Tel Aviv Academic College of Engineering
Subjects: Truncation error (numerical integration), Mathematics::Analysis of PDEs, Zero (complex analysis), 010103 numerical & computational mathematics, Type (model theory), 01 natural sciences, 010305 fluids & plasmas, Physics::Fluid Dynamics, Fourth order, Planar, Rate of convergence, 0103 physical sciences, Convergence (routing), Stream function, Applied mathematics, 0101 mathematics, [MATH]Mathematics [math], ComputingMilieux_MISCELLANEOUS, Mathematics
Abstract: International audience; Here we present a new approach for the analysis of high-order compact schemes for the clamped plate problem. A similar model is the Navier-Stokes equation in streamfunction formulation. In our book “Navier-Stokes Equations in Planar Domains”, Imperial College Press, 2013, we have suggested fourth-order compact schemes for the Navier-Stokes equations. The same type of schemes may be applied to the clamped plate problem. For these methods the truncation error is only of first-order at near-boundary points, but is of fourth order at interior points. It is proven that the rate of convergence is actually four, thus the error tends to zero as O(h4).
Published: 2021

26. Interpolation on the Cubed Sphere with Spherical Harmonics

Author: Jean-Baptiste Bellet, Matthieu Brachet, Jean-Pierre Croisille, Institut Élie Cartan de Lorraine (IECL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Mathématiques et Applications (LMA-Poitiers), and Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)
Subjects: Computational Mathematics, Spherical Harmonics, Romboidal Truncation, Applied Mathematics, Poisson equation on the sphere, 2010 Mathematics Subject Classification : 65-41-35, Spectral approximation on the sphere, Cubed Sphere Grid, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA]
Abstract: We consider the Lagrange interpolation with Spherical Harmonics of data located on the equiangular Cubed Sphere. A new approach based on a suitable Echelon Form of the associated Vandermonde matrix is carried out. As an outcome, a particular subspace of Spherical Harmonics is defined. This subspace possesses a high-frequency truncation, reminiscent of the rhomboidal truncation. Numerical results show the interest of this approach in various contexts. In particular, several examples of resolution of the Poisson equation on the sphere are displayed.
Published: 2021

27. Quantitative Magnetic Resonance Imaging Assessment of the Quadriceps Changes during an Extreme Mountain Ultramarathon

Author: Hoai-Thu Nguyen, Benjamin Gilles, Grégoire P. Millet, Rémi Grange, Benjamin Leporq, Pierre Croisille, Sylvain Grange, Thomas Grenier, Magalie Viallon, Caroline Le Goff, Olivier Beuf, RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Modeling & analysis for medical imaging and Diagnosis (MYRIAD), Laboratoire d'Informatique de Robotique et de Microélectronique de Montpellier (LIRMM), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)
Subjects: Longitudinal study, medicine.medical_specialty, Quantitative magnetic resonance imaging, Physical Therapy, Sports Therapy and Rehabilitation, Marathon Running, Quadriceps Muscle, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Post-hoc analysis, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Eccentric, Medicine, Humans, Orthopedics and Sports Medicine, Longitudinal Studies, Analysis of Variance, Prolonged exercise, business.industry, Quadriceps muscle, 030229 sport sciences, Magnetic Resonance Imaging, Italy, Athletes, Serological biomarkers, business, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; AbstractIntroduction/Purpose Extreme ultra-endurance races are growing in popularity, but their effects on skeletal muscles remain mostly unexplored. This longitudinal study explores physiological changes in mountain ultramarathon athletes’ quadriceps using quantitative magnetic resonance imaging (MRI) coupled with serological biomarkers. The study aimed to monitor the longitudinal effect of the race and recovery and to identify local inflammatory and metabolic muscle responses by codetection of biological markers.Methods An automatic image processing framework was designed to extract imaging-based biomarkers from quantitative MRI acquisitions of the upper legs of 20 finishers at three time points. The longitudinal effect of the race was demonstrated by analyzing the image markers with dedicated biostatistical analysis.Results Our framework allows for a reliable calculation of statistical data not only inside the whole quadriceps volume but also within each individual muscle head. Local changes in MRI parameters extracted from quantitative maps were described and found to be significantly correlated with principal serological biomarkers of interest. A decrease in the PDFF after the race and a stable paramagnetic susceptibility value were found. Pairwise post hoc tests suggested that the recovery process differs among the muscle heads.Conclusions This longitudinal study conducted during a prolonged and extreme mechanical stress showed that quantitative MRI-based markers of inflammation and metabolic response can detect local changes related to the prolonged exercise, with differentiated involvement of each head of the quadriceps muscle as expected in such eccentric load. Consistent and efficient extraction of the local biomarkers enables to highlight the interplay/interactions between blood and MRI biomarkers. This work indeed proposes an automatized analytic framework to tackle the time-consuming and mentally exhausting segmentation task of muscle heads in large multi–time-point cohorts.
Published: 2021

28. Significance of Hemodynamics Biomarkers, Tissue Biomechanics and Numerical Simulations in the Pathogenesis of Ascending Thoracic Aortic Aneurysms

Author: Stéphane Avril, Francesca Condemi, Pierre Croisille, Raja Jayendiran, Salvatore Campisi, Magalie Viallon, Avril, Stéphane, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: medicine.medical_specialty, [SDV]Life Sciences [q-bio], vascular remodeling, Hemodynamics, Aorta, Thoracic, Pathogenesis, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Tissue biomechanics, [SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Drug Discovery, medicine, Humans, aortic dissection, Aortic rupture, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Pharmacology, Aortic dissection, 0303 health sciences, medicine.diagnostic_test, Aortic Aneurysm, Thoracic, business.industry, 030305 genetics & heredity, Biomechanics, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Magnetic resonance imaging, Computational Fluid Dynamics, medicine.disease, Magnetic Resonance Imaging, wall shear stress, 3. Good health, Biomechanical Phenomena, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Aortic Valve, Cardiology, cardiovascular system, Ascending thoracic aorta aneurysms, Personalized medicine, Stress, Mechanical, business, Biomarkers
Abstract: Guidelines for the treatment of aortic wall diseases are based on measurements of maximum aortic diameter. However, aortic rupture or dissections do occur for small aortic diameters. Growing scientific evidence underlines the importance of biomechanics and hemodynamics in aortic disease development and progression. Wall shear stress (WWS) is an important hemodynamics marker that depends on aortic wall morphology and on the aortic valve function. WSS could be helpful to interpret aortic wall remodeling and define personalized risk criteria. The complementarity of Computational Fluid Dynamics and 4D Magnetic Resonance Imaging as tools for WSS assessment is a promising reality. The potentiality of these innovative technologies will provide maps or atlases of hemodynamics biomarkers to predict aortic tissue dysfunction. Ongoing efforts should focus on the correlation between these non-invasive imaging biomarkers and clinico-pathologic situations for the implementation of personalized medicine in current clinical practice.
Published: 2021

29. Colchicine for Left Ventricular Infarct Size Reduction in Acute Myocardial Infarction: A Phase II, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study Protocol – The COVERT-MI Study

Author: François Roubille, Loïc Bière, Naoual El Jonhy, Nathan Mewton, Gilles Rioufol, Olivier Dubreuil, Delphine Maucort-Boulch, Thomas Bochaton, Georges Sideris, Fabrice Prunier, Didier Bresson, Charles De Bourguignon, Carole Dhelens, Claire Bouleti, Cyril Prieur, Fabrice Ivanes, Florent Boutitie, Michel Ovize, Denis Angoulvant, Meyer Elbaz, Nathalie Dufay, Pierre Croisille, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Emile Muller [Mulhouse] (CH E.Muller Mulhouse), Groupe Hospitalier de Territoire Haute Alsace (GHTHA), Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), EA4245 - Transplantation, Immunologie, Inflammation [Tours] (T2i), Université de Tours (UT), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Centre d'Investigation Clinique [Bron] (CIC1407), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupement Hospitalier Est [Bron], Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Neurobiotec [HCL, Lyon], Hospices Civils de Lyon, Departement de Neurologie (HCL), Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hôpital Edouard Herriot [CHU - HCL], Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Nord (Saint Etienne), and MORNET, Dominique
Subjects: 0301 basic medicine, Adult, medicine.medical_specialty, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Placebo-controlled study, Myocardial Infarction, Acute myocardial infarction, Placebo, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Clinical Trials, Phase II as Topic, Percutaneous Coronary Intervention, Internal medicine, medicine, Humans, Multicenter Studies as Topic, Pharmacology (medical), cardiovascular diseases, Myocardial infarction, Prospective Studies, Ventricular remodeling, ComputingMilieux_MISCELLANEOUS, Randomized Controlled Trials as Topic, Inflammation, Ejection fraction, business.industry, Left ventricular remodeling, Percutaneous coronary intervention, Stroke Volume, medicine.disease, Magnetic Resonance Imaging, 3. Good health, ST-segment elevation myocardial infarction, [SDV] Life Sciences [q-bio], 030104 developmental biology, Treatment Outcome, 030220 oncology & carcinogenesis, Heart failure, Cardiology, Cardiology and Cardiovascular Medicine, business, Colchicine, TIMI
Abstract: Inflammatory processes have been identified as key mediators of ischemia-reperfusion injury in ST-segment elevation myocardial infarction (STEMI). They add damage to the myocardium and are associated with clinical adverse events (heart failure and cardiovascular death) and poor myocardial recovery. Colchicine is a well-known alkaloid with potent anti-inflammatory properties. In a proof-of-concept phase II trial, colchicine has been associated with a significant 50% reduction of infarct size (assessed by creatine kinase levels) in comparison to placebo in acute STEMI patients referred for primary percutaneous coronary intervention (PPCI). The Colchicine in STEMI Patients Study (COVERT-MI) is an ongoing confirmative prospective, multicenter, randomized, double-blind trial testing whether a short course oral treatment with colchicine versus placebo decreases myocardial injury in patients presenting with STEMI referred for PPCI. Adult patients, with a first STEMI episode and an initial TIMI flow ≤1, referred for PPCI, will be randomized (n = 194) in a 1:1 ratio to receive an oral bolus of colchicine of 2 mg followed by 0.5 mg b.i.d. treatment during 5 days or matching placebo. The primary endpoint will be the reduction in infarct size as assessed by cardiac magnetic resonance at 5 ± 2 days between both groups. The main secondary endpoints will be tested between groups in hierarchical order with left ventricular ejection fraction at 5 days, microvascular obstruction presence at 5 days, and absolute adverse left ventricular remodeling between 5 days and 3 months. This academic study is being financed by a grant from the French Ministry of Health (PHRCN-16-0357). Results from this study will contribute to a better understanding of the complex pathophysiology underlying myocardial injury after STEMI. The present study describes the rationale, design, and methods of the trial.
Published: 2021

30. Characterizing myocardial ischemia and reperfusion patterns with hierarchical manifold learning

Author: Benoît Freiche, Patrick Clarysse, Magalie Viallon, Pierre Croisille, Nicolas Duchateau, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Modeling & analysis for medical imaging and Diagnosis (MYRIAD), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), ANR-19-CE45-0005,MIC-MAC,Modélisation de la hiérarchie entre descripteurs cardiaques par apprentissage automatique(2019), ANR-11-LABX-0063,PRIMES,Physique, Radiobiologie, Imagerie Médicale et Simulation(2011), Freiche, Benoit, Modélisation de la hiérarchie entre descripteurs cardiaques par apprentissage automatique - - MIC-MAC2019 - ANR-19-CE45-0005 - AAPG2019 - VALID, and Physique, Radiobiologie, Imagerie Médicale et Simulation - - PRIMES2011 - ANR-11-LABX-0063 - LABX - VALID
Subjects: Manifold learning, Myocardial infarction, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, Information fusion, Cardiac imaging, Decision Hierarchy
Abstract: International audience; We aim at better understanding the mechanisms of ischemia and reperfusion, in the context of acute myocardial infarction. For this purpose, imaging and in particular magnetic resonance imaging are of great value in the clinic, but the richness of the images is currently under exploited. In this paper, we propose to characterize myocardial ischemia and reperfusion patterns across a population beyond the scalar measurements used in the clinic. Specifically, we adapted representation learning techniques to not only characterize the population distribution in terms of scar and microvascular obstruction patterns, but also regarding the appearance of late gadolinium images which reflects tissue heterogeneity. To do so, we implemented a hierarchical manifold learning approach where the embedding from a higher-level content (the images) is guided by one from a lower-level content (the infarct and microvascular obstruction segmentations). We demonstrate its relevance on 1711 late gadolinium enhancement slices from 123 patients with acute ST-elevation myocardial infarction. We designed ways to balance the contribution of each level in the hierarchy, and quantify its impact on the overall distribution and on sample neighborhoods. We notably observe that the obtained latent space is a balanced contribution between the two levels of the hierarchy, and is more robust to challenging images subjected to artifacts or specific lesion patterns.
Published: 2021

31. Myofiber strain in healthy humans using DENSE and cDTI

Author: Luigi E. Perotti, Ilya A. Verzhbinsky, Daniel B. Ennis, Kevin Moulin, Magalie Viallon, Pierre Croisille, Stanford University, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), University of California [San Diego] (UC San Diego), University of California (UC), University of Central Florida [Orlando] (UCF), and GAUTHERON, Arthur
Subjects: [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Population, Magnetic Resonance Imaging, Cine, Article, 030218 nuclear medicine & medical imaging, Contractility, 03 medical and health sciences, 0302 clinical medicine, In vivo, myofiber strain, Circumferential strain, Myocyte, Humans, Radiology, Nuclear Medicine and imaging, Myocytes, Cardiac, DENSE, education, Physics, education.field_of_study, Strain (chemistry), Phantoms, Imaging, Healthy Volunteers, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Potential biomarkers, Acquisition time, 030217 neurology & neurosurgery, Biomedical engineering, cDTI
Abstract: Purpose: Myofiber strain, Eff , is a mechanistically relevant metric of cardiac cell shortening and is expected to be spatially uniform in healthy populations, making it a prime candidate for the evaluation of local cardiomyocyte contractility. In this study, a new, efficient pipeline was proposed to combine microstructural cDTI and functional DENSE data in order to estimate Eff in vivo.Methods: Thirty healthy volunteers were scanned with three long-axis (LA) and three short-axis (SA) DENSE slices using 2D displacement encoding and one SA slice of cDTI. The total acquisition time was 11 minutes ± 3 minutes across volunteers. The pipeline first generates 3D SA displacements from all DENSE slices which are then combined with cDTI data to generate a cine of myofiber orientations and compute Eff . The precision of the post-processing pipeline was assessed using a computational phantom study. Transmural myofiber strain was compared to circumferential strain, Ecc , in healthy volunteers using a Wilcoxon sign rank test.Results: In vivo, computed Eff was found uniform transmurally compared to Ecc (-0.14[-0.15, -0.12] vs -0.18 [-0.20, -0.16], P < .001, -0.14 [-0.16, -0.12] vs -0.16 [-0.17, -0.13], P < .001 and -0.14 [-0.16, -0.12] vs Ecc_C = -0.14 [-0.15, -0.11], P = .002, Eff_C vs Ecc_C in the endo, mid, and epi layers, respectively).Conclusion: We demonstrate that it is possible to measure in vivo myofiber strain in a healthy human population in 10 minutes per subject. Myofiber strain was observed to be spatially uniform in healthy volunteers making it a potential biomarker for the evaluation of local cardiomyocyte contractility in assessing cardiovascular dysfunction.
Published: 2021

32. Predictive value of early cardiac magnetic resonance imaging functional and geometric indexes for adverse left ventricular remodelling in patients with anterior ST-segment elevation myocardial infarction: A report from the CIRCUS study

Author: Nathan Mewton, Geneviève Derumeaux, Cyrille Bergerot, Michel Ovize, Thomas Hovasse, Fabien De Poli, François Roubille, Mathieu Schaaf, Fabrice Prunier, Claire Jossan, Martine Gilard, Loïc Bière, Elbaz Meyer, David Garcia-Dorado, Hélène Thibault, Camille Amaz, Thien-Tri Cung, Timothée Besseyre Des Horts, Pierre Croisille, Théo Pezel, Division of Cardiology, Johns-Hopkins University, 21287-0409 Baltimore, MD, Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Radiology Department, University Hospital of Saint-Étienne, 42270 Saint-Priest-en-Jarez, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), CIBERCV, Hospital Universitari Vall d'Hebron & Research Institute, Universitat Autònoma de Barcelona, 08035 Barcelona, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital de Rangueil, CHU Toulouse [Toulouse], Hôpital Henri Mondor, Haguenau Hospital, 67500 Haguenau, Jacques-Cartier Institute, 91300 Massy, Department of Cardiology, Brest University Hospital, 29200 Brest, MORNET, Dominique, Universitat Autònoma de Barcelona (UAB), and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
Subjects: Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Magnetic Resonance Imaging, Cine, 030204 cardiovascular system & hematology, Anterior ST segment elevation, Risk Assessment, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Percutaneous Coronary Intervention, Double-Blind Method, Cardiac magnetic resonance imaging, Predictive Value of Tests, Internal medicine, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, Anterior Wall Myocardial Infarction, ComputingMilieux_MISCELLANEOUS, Aged, medicine.diagnostic_test, Ventricular Remodeling, business.industry, Percutaneous coronary intervention, General Medicine, Odds ratio, Middle Aged, medicine.disease, Confidence interval, 3. Good health, [SDV] Life Sciences [q-bio], Early Diagnosis, Treatment Outcome, Heart Disease Risk Factors, Heart failure, Injections, Intravenous, Cardiology, Cyclosporine, ST Elevation Myocardial Infarction, Female, France, Cardiology and Cardiovascular Medicine, business, Mace
Abstract: Postinfarction adverse left ventricular (LV) remodelling is strongly associated with heart failure events. Conicity index, sphericity index and LV global functional index (LVGFI) are new LV remodelling indexes assessed by cardiac magnetic resonance (CMR).To assess the predictive value of the new indexes for 1-year adverse LV remodelling in patients with anterior ST-segment elevated myocardial infarction (STEMI).CMR studies were performed in 129 patients with anterior STEMI (58±12 years; 78% men) from the randomized CIRCUS trial (CMR substudy) treated with primary percutaneous coronary intervention and followed for the occurrence of major adverse cardiovascular events (MACE) (death or hospitalization for heart failure). Conicity index, sphericity index, LVGFI, infarct size and microvascular obstruction (MVO) were assessed by CMR performed 5±4 days after coronary reperfusion. Adverse LV remodelling was defined as an increase in LV end-diastolic volume of ≥15% by transthoracic echocardiography at 1 year.Adverse LV remodelling occurred in 27% of patients at 1 year. Infarct size and MVO were significantly predictive of adverse LV remodelling: odds ratio [OR] 1.03, 95% confidence interval [CI] 1.01-1.05 (P0.001) and OR 1.12, 95% CI 1.05-1.22 (P0.001), respectively. Among the newly tested indexes, only LVGFI was significantly predictive of adverse LV remodelling (OR 1.10, 95% CI 1.03-1.16; P=0.001). In multivariable analysis, infarct size remained an independent predictor of adverse LV remodelling at 1 year (OR 1.05, 95% CI 1.02-1.08; P0.001). LVGFI and infarct size were associated with occurrence of MACE: OR 1.21, 95% CI 1.08-1.37 (P0.001) and OR 1.02, 95% CI 1.00-1.04 (P=0.018), respectively. Conicity and sphericity indexes were not associated with MACE.LVGFI was associated with adverse LV remodelling and MACE 1 year after anterior STEMI.
Published: 2020

33. Hemodynamics alteration in patient-specific dilated ascending thoracic aortas with tricuspid and bicuspid aortic valves

Author: R. Jayendiran, Stéphane Avril, Pierre Croisille, Magalie Viallon, Salvatore Campisi, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Aortic valve, medicine.medical_specialty, Aortic root, [SDV]Life Sciences [q-bio], 0206 medical engineering, Heart Valve Diseases, Biomedical Engineering, Biophysics, Hemodynamics, Aorta, Thoracic, 02 engineering and technology, Thoracic aortic aneurysm, 03 medical and health sciences, 0302 clinical medicine, Aneurysm, Bicuspid Aortic Valve Disease, medicine.artery, Internal medicine, Ascending aorta, medicine, Humans, Orthopedics and Sports Medicine, In patient, ComputingMilieux_MISCELLANEOUS, business.industry, Rehabilitation, Blood flow, medicine.disease, 020601 biomedical engineering, medicine.anatomical_structure, Aortic Valve, cardiovascular system, Cardiology, business, 030217 neurology & neurosurgery
Abstract: In this paper, we evaluate computationally the influence of blood flow eccentricity and valve phenotype (bicuspid (BAV) and tricuspid (TAV) aortic valve) on hemodynamics in ascending thoracic aortic aneurysm (ATAA) patients. 5 TAV ATAA, 5 BAV ATAA (ascending aorta diameter > 35 mm) and 2 healthy subjects underwent 4D flow MRI. The 3D velocity profiles obtained from 4D flow MRI were given as input boundary conditions to a computational fluid dynamics analysis (CFD) model. After performing the CFD analyses, we verified that the obtained time-averaged velocity profiles and flow eccentricity were in good agreement with 4D flow MRI. Then we used the CFD analyses to evaluate the time-averaged wall shear stress (TAWSS) and the local normalized helicity (LNH). We found that the flow eccentricities at the aortic root were not significantly different (p > 0.05) between TAV and BAV phenotypes. TAWSS (R2 = 0.697, p = 0.025) and absolute LNH (R2 = 0.964, p 0.001) are in good correlation with flow eccentricity. We conclude that eccentricity at the aortic root is a major determinant of hemodynamics patterns in ATAA patients regardless of the aortic valve phenotype.
Published: 2020

34. Computational prediction of hemodynamical and biomechanical alterations induced by aneurysm dilatation in patient‐specific ascending thoracic aortas

Author: Pierre Croisille, Stéphane Avril, R. Jayendiran, Magalie Viallon, Salvatore Campisi, Francesca Condemi, RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: medicine.medical_specialty, 0206 medical engineering, Biomedical Engineering, Hemodynamics, Aorta, Thoracic, 02 engineering and technology, 030204 cardiovascular system & hematology, [SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph], 03 medical and health sciences, Mechanobiology, 0302 clinical medicine, Aneurysm, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Shear stress, medicine, Humans, In patient, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Body surface area, Aortic Aneurysm, Thoracic, business.industry, Applied Mathematics, [INFO.INFO-CE]Computer Science [cs]/Computational Engineering, Finance, and Science [cs.CE], Healthy subjects, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Blood flow, medicine.disease, 020601 biomedical engineering, Computational Theory and Mathematics, Modeling and Simulation, Cardiology, Hydrodynamics, Stress, Mechanical, business, Shear Strength, Software
Abstract: The aim of the present work is to propose a robust computational framework combining computational fluid dynamics (CFD) and 4D flow MRI to predict the progressive changes in hemodynamics and wall rupture index (RPI) induced by aortic morphological evolutions in patients harboring ascending thoracic aortic aneurysms (ATAAs). An analytical equation has been proposed to predict the aneurysm progression based on age, sex, and body surface area. Parameters such as helicity, wall shear stress (WSS), time-averaged WSS, oscillatory shear index, relative residence time, and viscosity were evaluated for two patients at different stages of aneurysm growth, and compared with age-sex-matched healthy subjects. The study shows that evolution of hemodynamics and RPI, despite being very slow in ATAAs, is strongly affected by morphological alterations and, in turn could impact biomechanical factors and aortic mechanobiology. An aspect of the current work is that the patient-specific 4D MRI data sets were obtained with a follow-up of 1 year and the measured time-averaged velocity maps and flow eccentricity were compared with the CFD simulation for validation. The computational framework presented here is capable of capturing the blood flow patterns and the hemodynamic descriptors during the various stages of aneurysm growth. Further investigations will be conducted in order to verify these results on a larger cohort of patients and with long follow-up times to finally elucidate the link between deranged hemodynamics, AA geometry, and wall mechanical properties in ATAAs.
Published: 2020

35. Reliability of standardized ultrasound measurements of quadriceps muscle thickness in neurological critically ill patients: a comparison to computed tomography measures

Author: Laetitia Burnol, Serge Molliex, Pierre Croisille, Charline Tourel, Julien Lanoiselé, Magalie Viallon, Jérôme Morel, RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, muscle atrophy, Population, Physical Therapy, Sports Therapy and Rehabilitation, RM1-950, law.invention, 03 medical and health sciences, 0302 clinical medicine, Quality of life, law, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, critical illness, Prospective Studies, education, Reliability (statistics), ComputingMilieux_MISCELLANEOUS, education.field_of_study, quadriceps muscle, business.industry, Rehabilitation, Ultrasound, computed tomography scan, Reproducibility of Results, muscle wasting, 030208 emergency & critical care medicine, ultrasonography, General Medicine, Middle Aged, Intensive care unit, Muscle atrophy, Confidence interval, Muscular Atrophy, 030228 respiratory system, Quality of Life, Female, Patella, Therapeutics. Pharmacology, medicine.symptom, Tomography, X-Ray Computed, Nuclear medicine, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Objective Muscle atrophy is frequent in critically ill patients and is associated with increased mortality and long-lasting alteration in quality of life. Muscle ultrasound has not been clearly validated in intensive care unit patients. The aim of this study was to compare the level of agreement between ultrasound and computed tomography scan for the measurement of quadriceps muscle thickness. Design A prospective observational study. Patients Forty-two consecutive patients admitted to a neurological intensive care unit. Methods Quadriceps thickness was measured 15 cm above the upper edge of the patella. Iterative brain computed tomography scans were associated with a quadriceps-centred acquisition sequence. Concomitantly, an ultrasound of the quadriceps was performed. The position of the studied leg was standardized for ultrasound and computed tomography. Results A total of 73 measurements of ultrasound and computed tomography quadriceps thickness were compared. The correlation between both measures was 0.93 (95% confidence interval (95% CI) 0.84-1.02). Intra-rater reliability of ultrasound measurements and inter-rater reliability were excellent, with an ICC of 0.98 (95% CI 0.97-0.99) and 0.96 (95% CI 0.92-0.98), respectively. Conclusion A specific ultrasound set-up for measurement of quadriceps thickness is reliable and reproducible in an intensive care unit population.
Published: 2020

36. MRI of Reperfused Acute Myocardial Infarction Edema: ADC Quantification versus T1 and T2 Mapping

Author: Kevin Moulin, Pierre Croisille, Alban Chazot, Nathan Mewton, Karl Isaaz, William Romero, Magalie Viallon, Department of Medical Imaging and Information Sciences, Interventional Neuroradiology Unit, Geneva University Hospital (HUG), Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, [SDV]Life Sciences [q-bio], Myocardial Infarction, Cardiomyopathy, Myocardial Reperfusion Injury, Sensitivity and Specificity, 030218 nuclear medicine & medical imaging, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Edema, medicine, Humans, Effective diffusion coefficient, Radiology, Nuclear Medicine and imaging, Multislice, Prospective Studies, Myocardial infarction, Aged, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Confidence interval, 030220 oncology & carcinogenesis, Heart failure, Female, medicine.symptom, business, Nuclear medicine, Magnetic Resonance Angiography
Abstract: International audience; Background After acute myocardial infarction (AMI), reperfusion injury is associated with microvascular lesions and myocardial edema. Purpose To evaluate the performance of apparent diffusion coefficient (ADC) quantification compared with T1 and T2 values in the detection of acute myocardial injury. Materials and Methods In this prospective study conducted from June 2016 to November 2018, participants without a history of heart failure or cardiomyopathy were enrolled after undergoing reperfusion for their first AMI. Quantitative T1 and T2 mapping were performed with a 1.5-T MRI scanner and compared with a fast free-breathing acquisition technique for ADC mapping (approximate duration, 3 minutes; five slices; spin-echo cardiac diffusion acquisition; b values, 0 and 200 sec/mm(2); six diffusion-encoding directions; five repetitions). Quantitative ADC and unenhanced T1 and T2 values were compared in infarct, border, and remote regions by using Welch analysis of variance with Games-Howell post hoc test for pairwise comparisons. Results Thirty-four participants with AMI underwent MRI an average of 5 days ± 1.9 (standard deviation) after reperfusion. Mean ADC was markedly high in the infarcted regions (2.32 × 10(-3) mm(2)/sec; 95% confidence interval [CI]: 2.28, 2.36) and moderately high in the border regions (1.91 ×10(-3) mm(2)/sec; 95% CI: 1.89, 1.94; P \textless .001). In remote regions, mean ADC (1.62 ×10(-3) mm(2)/sec; 95% CI: 1.59, 1.64) was comparable to that measured in vivo in healthy volunteers. Within the same regions of interest, although the measures showed similar trends in infarct and remote regions for T1 (mean, 1332 mec [95% CI: 1296, 1368] vs 1045 msec [95% CI: 1034, 1056]; P \textless .001) and T2 (72 msec [95% CI: 69, 75] vs 50 msec [95% CI: 49, 51]; P \textless .001), the magnitude of the differences among regions was greater when using ADC. Normalized signal differences between infarct and remote regions showed that diffusion-weighted MRI depicted edema 5.1 (P \textless .001) and 3.5 (P \textless .001) times greater than did T1 and T2 maps, respectively. Conclusion Multislice cardiac diffusion-weighted images could be acquired in those with acute myocardial injury. Quantitative apparent diffusion coefficient mapping showed greater differences among remote regions and lesions than did T1 or T2 mapping.
Published: 2020

37. A cartesian compact scheme for the Navier-Stokes equations in streamfunction formulation in irregular domains

Author: Jean-Pierre Croisille, Dalia Fishelov, Matania Ben-Artzi, Institut Élie Cartan de Lorraine (IECL), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), The Hebrew University of Jerusalem (HUJ), and AFEKA: Tel Aviv Academic College of Engineering
Subjects: 01 natural sciences, Theoretical Computer Science, law.invention, law, Stream function, Biharmonic problem, Applied mathematics, Cartesian coordinate system, 0101 mathematics, [MATH]Mathematics [math], Navier–Stokes equations, Mathematics, Numerical Analysis, Hermite polynomials, Series (mathematics), Applied Mathematics, General Engineering, embedded compact scheme, 010101 applied mathematics, Computational Mathematics, Computational Theory and Mathematics, Scheme (mathematics), Biharmonic equation, Navier-Stokes equations, Software, Interpolation
Abstract: In Ben-Artzi et al. (SIAM J Numer Anal 47:3087–3108, 2009) we introduced an embedded Cartesian scheme for the biharmonic problem in two dimensions. Here we extend this methodology to the 2D Navier–Stokes system. Hermite (or Birkhoff) interpolation is invoked in one and two dimensions to obtain finite difference operators. The consistency analysis of the discrete formulas for irregular grids is emphasized. Numerical results demonstrate remarkable accuracy for a series of test cases for flows in elliptical domains.
Published: 2019

38. Corrigendum to 'Automatic myocardial ischemic lesion detection on magnetic resonance perfusion weighted imaging prior perfusion quantification: A pre-modeling strategy' [Comput. Biol. Med. 110 (2019) 108–119]

Author: Michaël Sdika, Thomas Grenier, Clément Daviller, Hélène Ratiney, Magalie Viallon, Pierre Croisille, RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Modeling & analysis for medical imaging and Diagnosis (MYRIAD)
Subjects: 0303 health sciences, business.industry, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Health Informatics, 3. Good health, 030218 nuclear medicine & medical imaging, Computer Science Applications, Magnetic resonance perfusion, 03 medical and health sciences, 0302 clinical medicine, Text mining, Ischemic lesion, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Medicine, business, Nuclear medicine, Perfusion, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology
Abstract: International audience
Published: 2019

39. Comparison of strain imaging techniques in CRT candidates: CMR tagging, CMR feature tracking and speckle tracking echocardiography

Author: Marc A. Vos, Isabelle C. Van Gelder, Patrick Clarysse, Maarten J. Cramer, Kevin Vernooy, Alexander H. Maass, Albert C. van Rossum, Michiel Rienstra, Wouter M. van Everdingen, Bastiaan Geelhoed, Cornelis P Allaart, Odette A.E. Salden, Robin Nijveldt, Alwin Zweerink, Mathias Meine, Frederik J. de Lange, Pierre Croisille, Cardiologie, RS: CARIM - R2.08 - Electro mechanics, MUMC+: MA Med Staf Spec Cardiologie (9), Cardiology, ACS - Heart failure & arrhythmias, Cardiovascular Centre (CVC), ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, ICaR-VU, VU University Medical Center [Amsterdam], Department of Cardiology, Utrecht University [Utrecht], Maastricht University [Maastricht], RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE)
Subjects: Male, Discoordination, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Speckle tracking echocardiography, 030204 cardiovascular system & hematology, Ventricular Function, Left, 030218 nuclear medicine & medical imaging, Strain, 0302 clinical medicine, DIASTOLIC STRAIN, CONTRACTION, Prospective Studies, ComputingMilieux_MISCELLANEOUS, Cardiac imaging, LONGITUDINAL STRAIN, Netherlands, Cardiac resynchronization therapy, MECHANICAL DYSSYNCHRONY, Middle Aged, musculoskeletal system, Biomechanical Phenomena, Echocardiography, Predictive value of tests, cardiovascular system, HEART-FAILURE, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Female, Cardiology and Cardiovascular Medicine, SEPTAL REBOUND STRETCH, Myocardial tagging, BUNDLE-BRANCH BLOCK, circulatory and respiratory physiology, endocrine system, Clinical Decision-Making, Magnetic Resonance Imaging, Cine, 03 medical and health sciences, LEFT-VENTRICULAR DYSFUNCTION, Predictive Value of Tests, medicine, Humans, Radiology, Nuclear Medicine and imaging, Cardiac Resynchronization Therapy Devices, cardiovascular diseases, Aged, Heart Failure, Original Paper, Bundle branch block, business.industry, Patient Selection, Strain imaging, medicine.disease, Myocardial Contraction, Feature tracking, Dyssynchrony, Heart failure, PATTERNS, Nuclear medicine, business
Abstract: Parameters using myocardial strain analysis may predict response to cardiac resynchronization therapy (CRT). As the agreement between currently available strain imaging modalities is unknown, three different modalities were compared. Twenty-seven CRT-candidates, prospectively included in the MARC study, underwent cardiac magnetic resonance (CMR) imaging and echocardiographic examination. Left ventricular (LV) circumferential strain was analysed with CMR tagging (CMR-TAG), CMR feature tracking (CMR-FT), and speckle tracking echocardiography (STE). Basic strain values and parameters of dyssynchrony and discoordination obtained with CMR-FT and STE were compared to CMR-TAG. Agreement of CMR-FT and CMR-TAG was overall fair, while agreement between STE and CMR-TAG was often poor. For both comparisons, agreement on discoordination parameters was highest, followed by dyssynchrony and basic strain parameters. For discoordination parameters, agreement on systolic stretch index was highest, with fair intra-class correlation coefficients (ICC) (CMR-FT: 0.58, STE: 0.55). ICC of septal systolic rebound stretch (SRSsept) was poor (CMR-FT: 0.41, STE: 0.30). Internal stretch factor of septal and lateral wall (ISFsep–lat) showed fair ICC values (CMR-FT: 0.53, STE: 0.46), while the ICC of the total LV (ISFLV) was fair for CMR-FT (0.55) and poor for STE (ICC: 0.32). The CURE index had a fair ICC for both comparisons (CMR-FT: 0.49, STE 0.41). Although comparison of STE to CMR-TAG was limited by methodological differences, agreement between CMR-FT and CMR-TAG was overall higher compared to STE and CMR-TAG. CMR-FT is a potential clinical alternative for CMR-TAG and STE, especially in the detection of discoordination in CRT-candidates. Electronic supplementary material The online version of this article (doi:10.1007/s10554-017-1253-5) contains supplementary material, which is available to authorized users.
Published: 2018

40. A gradient-based optical-flow cardiac motion estimation method for cine and tagged MR images

Author: Liang Wang, Zhengjun Liu, Patrick Clarysse, Wanyu Liu, Pierre Croisille, Bin Gao, Philippe Delachartre, Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Metislab, LIA CNRS Harbin Institute of Technology, RMN et optique : De la mesure au biomarqueur, and Imagerie Ultrasonore
Subjects: Computer science, Optical flow, Magnetic Resonance Imaging, Cine, Health Informatics, 02 engineering and technology, Motion (physics), Displacement (vector), 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Motion, 0302 clinical medicine, Motion estimation, 0202 electrical engineering, electronic engineering, information engineering, Image Processing, Computer-Assisted, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Radiology, Nuclear Medicine and imaging, ComputingMilieux_MISCELLANEOUS, Radiological and Ultrasound Technology, business.industry, Estimator, Pattern recognition, Heart, Function (mathematics), Random walk, Computer Graphics and Computer-Aided Design, Magnetic Resonance Imaging, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], 020201 artificial intelligence & image processing, Computer Vision and Pattern Recognition, Minification, Artificial intelligence, business, Algorithms
Abstract: A new method is proposed to quantify the myocardial motion from both 2D C(ine)-MRI and T(agged)-MRI sequences. The tag pattern offers natural landmarks within the image that makes it possible to accurately quantify the motion within the myocardial wall. Therefore, several methods have been proposed for T-MRI. However, the lack of salient features within the cardiac wall in C-MRI hampers local motion estimation. Our method aims to ensure the local intensity and shape features invariance during motion through the iterative minimization of a cost function via a random walk scheme. The proposed approach is evaluated on realistic simulated C-MRI and T-MRI sequences. The results show more than 53% improvements on displacement estimation, and more than 24% on strain estimation for both C-MRI and T-MRI sequences, as compared to state-of-the-art cardiac motion estimators. Preliminary experiments on clinical data have shown a good ability of the proposed method to detect abnormal motion patterns related to pathology. If those results are confirmed on large databases, this would open up the possibility for more accurate diagnosis of cardiac function from standard C-MRI examinations and also the retrospective study of prior studies.
Published: 2019

41. Motion‐induced signal loss in in vivo cardiac diffusion‐weighted imaging

Author: Sonia Nielles-Vallespin, Sebastian Kozerke, Magalie Viallon, Irvin Teh, David E. Sosnovik, Pierre Croisille, Elizabeth M. Tunnicliffe, David N. Firmin, Daniel B. Ennis, Pedro F. Ferreira, Kevin Moulin, Christian T. Stoeck, Andrew D Scott, Jürgen E. Schneider, RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de radiologie [Saint-Etienne], CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM), and University of Zurich
Subjects: Physics, 02 Physical Sciences, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Motion (geometry), Heart, 610 Medicine & health, Signal, 09 Engineering, Article, 170 Ethics, Nuclear Medicine & Medical Imaging, Motion, Diffusion Magnetic Resonance Imaging, Nuclear magnetic resonance, In vivo, Radiology Nuclear Medicine and imaging, Image Processing, Computer-Assisted, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, 2741 Radiology, Nuclear Medicine and Imaging, Radiology, Nuclear Medicine and imaging, 10237 Institute of Biomedical Engineering, 11 Medical and Health Sciences, ComputingMilieux_MISCELLANEOUS, Diffusion MRI
Abstract: 5 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:319-320.
Published: 2019

42. Automatic myocardial ischemic lesion detection on magnetic resonance perfusion weighted imaging prior perfusion quantification: A pre-modeling strategy

Author: Thomas Grenier, Michaël Sdika, Clément Daviller, Hélène Ratiney, Magalie Viallon, Pierre Croisille, RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Images et Modèles, Modeling & analysis for medical imaging and Diagnosis (MYRIAD), Service Informatique et développements, Service de radiologie [Saint-Etienne], CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Saint-Etienne-Université Jean Monnet - Saint-Étienne (UJM), and Ratiney, Helene
Subjects: 0301 basic medicine, Male, Computer science, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, Myocardial Ischemia, Health Informatics, Perfusion scanning, computer.software_genre, Lesion, 03 medical and health sciences, 0302 clinical medicine, Voxel, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Segmentation, Cluster analysis, ComputingMilieux_MISCELLANEOUS, medicine.diagnostic_test, Models, Cardiovascular, Myocardial Perfusion Imaging, Magnetic resonance imaging, Blood flow, Middle Aged, Computer Science Applications, 030104 developmental biology, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Female, medicine.symptom, Perfusion, computer, 030217 neurology & neurosurgery, Algorithms, Blood Flow Velocity, Magnetic Resonance Angiography, Biomedical engineering
Abstract: Even if cardiovascular magnetic resonance (CMR) perfusion imaging has proven its relevance for visual detection of ischemia, myocardial blood flow (MBF) quantification at the voxel observation scale remains challenging. Integration of an automated segmentation step, prior to perfusion index estimation, might be a significant reconstruction component that could allow sustainable assumptions and constraint enlargement prior to advanced modeling. Current clustering techniques, such as bullseye representation or manual delineation, are not designed to discriminate voxels belonging to the lesion from healthy areas. Hence, the resulting average time–intensity curve, which is assumed to represent the dynamic contrast enhancement inside of a lesion, might be contaminated by voxels with perfectly healthy microcirculation. This study introduces a hierarchical lesion segmentation approach based on time–intensity curve features that considers the spatial particularities of CMR myocardial perfusion. A first k-means clustering approach enables this method to perform coarse clustering, which is refined by a novel spatiotemporal region-growing (STRG) segmentation, thus ensuring spatial and time–intensity curve homogeneity. Over a cohort of 30 patients, myocardial blood flow (MBF) measured in voxels of lesion regions detected with STRG was significantly lower than in regions drawn manually (mean difference = 0.14, 95% CI [0.07, 0.2]) and defined with the bullseye template (mean difference = 0.25, 95% CI [0.17, 0.36]). Over the 90 analyzed slices, the median Dice score calculated against the ground truth ranged between 0.62 and 0.67, the inclusion coefficients ranged between 0.62 and 0.76 and the centroid distances ranged between 0.97 and 3.88 mm. Therefore, though these metrics highlight spatial differences, they could not be used as an index to evaluate the accuracy and performance of the method, which can only be attested by the variability of the MBF clinical index.
Published: 2019

43. Relationship between ascending thoracic aortic aneurysms hemodynamics and biomechanical properties

Author: Francesca Condemi, Salvatore Campisi, Pierre Croisille, Stéphane Avril, Magalie Viallon, Avril, Stéphane, INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU de Saint-Étienne Hôpital Nord (Saint Etienne), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Mines Saint-Etienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, F - 42023 Saint-Etienne France, Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Ingénierie et Santé (CIS-ENSMSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0206 medical engineering, Biomedical Engineering, Hemodynamics, Computed tomography, 02 engineering and technology, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Nuclear magnetic resonance, [SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], medicine, Humans, Computer Simulation, Statistical analysis, Rupture risk, Physics, Aortic Aneurysm, Thoracic, medicine.diagnostic_test, Cauchy stress tensor, [SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph], Magnetic Resonance Imaging, 020601 biomedical engineering, Biomechanical Phenomena, 3. Good health, Stress, Mechanical, Intensity (heat transfer), Burst pressure
Abstract: Objective: Ascending thoracic aortic aneu-rysm (aTAA) is a major cause of human deaths. Despite important recent progress to better understand its pathogenesis and development, the role played by deranged hemodynamics on aTAA risk of rupture is still partially unknown. Our aim was to develop and apply a novel methodology to assess the correlation between aTAA rupture risk and hemodynamic biomarkers combining for the first time in vivo , in vitro , and in silico analyses. Methods: Computational fluid dynamic analyses were performed and validated on ten patients using patient-specific data derived from CT scan and four-dimensional MRI. Systolic wall shear stress, time-averaged wall shear stress (TAWSS), flow eccentricity (Floweccentricity), and helicity intensity (h2) were assessed. A bulge inflation test was carried out in vitro on the ten aTAA samples resected during surgical repair. The biomechanical and rupture properties of these samples were derived: the burst pressure, the physiological tangent elastic modulus $({{{\bf{E}}_{{\bf{physio}}}}})$ , the Cauchy stress at rupture $({{{\bf{\sigma }}_{{\bf{rupt}}}}})$ , the rupture stretch $({{{\bf{\lambda }}_{{\bf{rupt}}}}})$ , and the rupture stretch criterion $({\Upsilon_{\boldsymbol{stretch}}})$ . Statistical analysis was performed to determine correlation between all variables. Results: Statistically highly significant (p ${{\bf{\lambda }}_{{\bf{rupt}}}}$ and the TAWSS (r = 0.867 and p = 0.001) was found. Conclusion: This study shows that relatively low TAWSS significantly correlates with reduced rupture properties in aTAAs. Significance: Understanding the pathogenesis of aTAA remains crucial to reduce morbidity and mortality. Our aim is to establish possible correlations between aTAA rupture risk and hemodynamic biomarkers by combining for the first time in vivo , in vitro , and in silico analyses.
Published: 2019

44. Time evolution of discrete fourth-order elliptic operators

Author: Matania Ben-Artzi, Jean-Pierre Croisille, Dalia Fishelov, Institut Élie Cartan de Lorraine (IECL), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 010103 numerical & computational mathematics, biharmonic operator, 01 natural sciences, Boundary values, Applied mathematics, 0101 mathematics, [MATH]Mathematics [math], Mathematics, Kuramoto-Sivashinsky equation, Numerical Analysis, boundary values, Hermitian derivative, Applied Mathematics, Time evolution, Kuramoto–Sivashinsky equation, discrete evolution, optimal convergence, 010101 applied mathematics, Computational Mathematics, Elliptic operator, Fourth order, December 10, discrete elliptic calculus, Secondary 65N12, 2018. 2010 Mathematics Subject Classification. Primary 65M06, Biharmonic equation, 65M15 fourth order parabolic equation, Analysis
Abstract: International audience; The evolution equation ∂ ∂t u = − ∂ ∂x 4 u + A(x) ∂ ∂x 2 u + A (x) ∂ ∂x u − B(x)u + f, x ∈ Ω = [0, 1], t ≥ 0, is considered. A discrete parabolic methodology is developed, based on a discrete elliptic (fourth-order) calculus. The main ingredient of this calculus is a discrete biharmonic operator (DBO). In the general case, it is shown that the approximate solutions converge to the continuous one. An "almost optimal" convergence result (O(h 4−ε)) is established in the case of constant coefficients, in particular in the pure biharmonic case. Several numerical test cases are presented, that not only corroborate the theoretical accuracy result, but also demonstrate high-order accuracy of the method in nonlinear cases. The nonlinear equations include the well studied Kuramoto-Sivashinsky equation. Numerical solutions for this equation are shown to approximate remarkably well the exact solutions. The numerical examples demonstrate the great improvement achieved by using the DBO instead of the standard (five-point) discrete bilaplacian.
Published: 2019

45. Evaluation of Peak Wall Stress in an Ascending Thoracic Aortic Aneurysm Using FSI Simulations: Effects of Aortic Stiffness and Peripheral Resistance

Author: Stéphane Avril, Francesca Condemi, Rossella Campobasso, Pierre Croisille, Magalie Viallon, Salvatore Campisi, INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)
Subjects: Male, Patient-Specific Modeling, Materials science, Aortic Rupture, 0206 medical engineering, Biomedical Engineering, Carreau fluid, FOS: Physical sciences, Aorta, Thoracic, 02 engineering and technology, 030204 cardiovascular system & hematology, Thoracic aortic aneurysm, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Aneurysm, Vascular Stiffness, Predictive Value of Tests, Risk Factors, medicine.artery, Image Interpretation, Computer-Assisted, medicine, Shear stress, Thoracic aorta, Humans, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], Aorta, Aortic Aneurysm, Thoracic, Models, Cardiovascular, Reproducibility of Results, Blood flow, Middle Aged, medicine.disease, Prognosis, 020601 biomedical engineering, Physics - Medical Physics, Regional Blood Flow, Aortic stiffness, Vascular Resistance, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Stress, Mechanical, Medical Physics (physics.med-ph), Cardiology and Cardiovascular Medicine, Magnetic Resonance Angiography, Biomedical engineering
Abstract: International audience; Purpose. It has been reported clinically that rupture or dissections in thoracic aortic aneurysms (TAA) often occur due to hypertension which may be modelled with sudden increase of peripheral resistance, inducing acute changes of blood volumes in the aorta. There is clinical evidence that more compliant aneurysms are less prone to rupture as they can sustain such changes of volume. The aim of the current paper is to verify this paradigm by evaluating computationally the role played by the variation of peripheral resistance and the impact of aortic stiffness onto peak wall stress in ascending TAA. Methods. Fluid-Structure Interaction (FSI) analyses were performed using patient-specific geometries and boundary conditions derived from 4D MRI datasets acquired on a patient. Blood was assumed incompressible and was treated as a non-Newtonian fluid using the Carreau model while the wall mechanical properties were obtained from the bulge inflation tests carried out in vitro after surgical repair. The Navier Stokes equations were solved in ANSYS Fluent. The Arbitrary Lagrangian Eulerian formulation was used to account for the wall deformations. At the interface between the solid domain and the fluid domain, the fluid pressure was transferred to the wall and the displacement of the wall was transferred to the fluid. The two systems were connected by the System Coupling component which controls the solver execution of fluid and solid simulations in ANSYS. Fluid and solid domains were solved sequentially starting from the fluid simulations. Results. Distributions of blood flow, wall shear stress and wall stress were evaluated in the ascending thoracic aorta using the FSI analyses. We always observed a significant flow eccentricity in the simulations, in very good agreement with velocity profiles measured using 4D MRI. The results also showed significant increase of peak wall stress due to the increase of peripheral resistance and aortic stiffness. In the worst case scenario, the largest peripheral resistance (10 10 kg.s.m-4) and stiffness (10 MPa) resulted in a maximal principal stress equal to 702 kPa, whereas it was only 77 kPa in normal conditions. Conclusions. This is the first time that the risk of rupture of an aTAA is quantified in case of the combined effects of hypertension and aortic stiffness increase. Our findings suggest that a stiffer TAA may have the most altered distribution of wall stress and an acute change of peripheral vascular resistance could significantly increase the risk of rupture for a stiffer aneurysm.
Published: 2018

46. Neprilysin levels at the acute phase of ST-elevation myocardial infarction

Author: Camille Amaz, Thomas Bochaton, Claire Jossan, Nathan Mewton, Pierre Croisille, Salim Si-Mohamed, Philippe Douek, Nathalie Dufay, Michel Ovize, E. Bonnefoy-Cudraz, Gilles Rioufol, H. Bernelin, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE), Department of Radiology, Cardiological Hospital, Hospices Civils de Lyon, Hospices Civils de Lyon (HCL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, medicine.medical_specialty, Time Factors, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, medicine.medical_treatment, Clinical Investigations, Magnetic Resonance Imaging, Cine, Enzyme-Linked Immunosorbent Assay, 030204 cardiovascular system & hematology, 03 medical and health sciences, Electrocardiography, 0302 clinical medicine, Percutaneous Coronary Intervention, Interquartile range, Internal medicine, Medicine, Humans, 030212 general & internal medicine, Myocardial infarction, Prospective Studies, Prospective cohort study, ComputingMilieux_MISCELLANEOUS, Ejection fraction, biology, business.industry, Myocardium, Hazard ratio, fungi, Percutaneous coronary intervention, Membrane Proteins, General Medicine, Middle Aged, medicine.disease, Prognosis, Troponin, 3. Good health, biology.protein, Cardiology, ST Elevation Myocardial Infarction, Creatine kinase, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers, Follow-Up Studies
Abstract: International audience; Background Several preliminary analyses suggested an association between neprilysin (NEP) levels and myocardial infarction. Hypothesis The objective was to assess whether NEP plasma levels following reperfusion might be a surrogate for infarct size (IS) or predict adverse outcomes in acute ST-segment elevation myocardial infarction (STEMI) patients. Methods We measured NEP levels in a prospective cohort of 203 patients with STEMI referred for primary percutaneous coronary intervention. Circulating soluble NEP was measured by enzyme-linked immunosorbent assay at admission (t0) and 4 hours later (t4) following reperfusion and on 7 times points (t0, t4, t12, t24, t48, day 7 and day 30) in a subset of 21 patients. IS and left ventricular ejection fraction (LVEF) were measured at 1 month by cardiac magnetic resonance. Adverse cardiovascular outcomes were collected at 12-month follow-up. Results Median t0 and t4 NEP levels in 203 patients were respectively 88.3 pg/mL (interquartile range [IQR] [14; 375.4]) and 101.5 pg/mL (IQR [18.5; 423.8]). These levels remained unchanged over 1 month (P = 0.70). NEP levels did not correlate significantly with IS (P = 0.51) or LVEF (P = 0.34). There was no correlation between NEP and troponin, creatine kinase and interleukin-6 levels at h0 and h4. NEP levels above the median were not associated with adverse outcomes at follow-up (hazard ratio = 1.28, 95% confidence interval [0.69; 2.37]; P = 0.42). Conclusions NEP serum levels were widely distributed and did not change significantly in the first hours and 1-month period following reperfusion in STEMI patients. There was no significant relationship with markers of infarct size and inflammation, and 1-year adverse outcomes
Published: 2018

47. Strain-Based Parameters for Infarct Localization: Evaluation via a Learning Algorithm on a Synthetic Database of Pathological Hearts

Author: Pierre Croisille, Jacques Ohayon, Patrick Clarysse, Gerardo Kenny Rumindo, Nicolas Duchateau, 1 - Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales ( MOTIVATE ), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Hospices Civils de Lyon ( HCL ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Hospices Civils de Lyon ( HCL ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), 5 - RMN et optique : De la mesure aux biomarqueurs, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications [Grenoble] ( TIMC-IMAG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), RMN et optique : De la mesure au biomarqueur, Dynamique Cellulaire et Tissulaire- Interdisciplinarité, Modèles & Microscopies (TIMC-IMAG-DyCTiM), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Duchateau, Nicolas, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Dynamiques Cellulaire et Tissulaire - Interdisciplinarité, Modélisation & Microscopie (TIMC-IMAG-DyCTiM2)
Subjects: Computer science, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, 030204 cardiovascular system & hematology, computer.software_genre, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Finite-element model, Machine learning, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Myocardial infarction, cardiovascular diseases, Pathological, Strain (chemistry), Database, Cardiac ischemia, Myocardial strain, medicine.disease, Thresholding, Clinical Practice, medicine.anatomical_structure, Ventricle, cardiovascular system, Myocardial infarct, computer, Algorithm, Infarct diagnosis
Abstract: International audience; Localization of infarcted regions is essential to determine the most appropriate treatment for patients with cardiac ischemia. Myocardial strain partially reflects the location of infarcted regions, which demonstrated potential use in clinical practice. However, strain patterns are complex and simple thresholding is not sufficient to locate the infarcts. Besides, many strain-based parameters exist and their sensitivities to myocardial infarcts have not been directly investigated. In our study, we propose to evaluate nine strain-based parameters to locate infarcted regions. For this purpose, we designed a large database (n = 200) of synthetic pathological finite-element heart models from 5 real healthy left ventricle geometries. The infarcts were incorporated with random location, shape and degree of severity. In addition, we used a state-of-the-art learning algorithm to link deformation patterns and infarct location. Based on our evaluation, we propose to sort the strain-based parameters into three groups according to their performances in locating infarcts.
Published: 2017

48. METHODOLOGIES ACOUSTIQUES DANS LE TRAITEMENT DE LA PHASE AIGUË DE L’INFARCTUS DU MYOCARDE

Author: Magalie Viallon, Lorena Petrusca, Djin, William Apoutou N., Claire Crola da Silva, Nathan Mewton, René FERRERA, Hervé Liebgott, Lionel Augeul, Michel Ovize, Jean-Yves Chapelon, Pierre Croisille, RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Applications des ultrasons à la thérapie, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Imagerie Ultrasonore, Hôpital nord, St Etienne, 1 - Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales ( MOTIVATE ), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Hospices Civils de Lyon ( HCL ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Hospices Civils de Lyon ( HCL ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), 5 - RMN et optique : De la mesure aux biomarqueurs, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Cardiovasculaire, métabolisme, diabétologie et nutrition ( CarMeN ), Institut National de la Recherche Agronomique ( INRA ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Hospices Civils de Lyon ( HCL ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), 3 - Imagerie Ultrasonore, Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National de la Recherche Agronomique (INRA), and Rayet, Béatrice
Subjects: [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging
Abstract: International audience; Les maladies cardiovasculaires restent la principale cause de mortalité chez l'adulte dans les pays industrialisés [1-3]. La taille de l'infarctus est le facteur majeur du pronostic après infarctus du myocarde aigu [4,5]. Les interventions visant à réduire la taille finale de l'infarctus ont donc un intérêt clinique majeur pour améliorer le pronostic des patients pris en charge pour infarctus du myocarde. La prise en charge actuelle de l’infarctus du myocarde vise à reperfuser le myocarde le plus rapidement possible, par angioplastie coronaire percutanée primaire le plus souvent [6]. Cependant des études expérimentales et cliniques ont montré qu’une reperfusion brutale avait aussi des effets délétères sur le myocarde ischémique et induisait des lésions de reperfusion supplémentaires [7, 8]. Ces dommages survenant après reperfusion peuvent participer jusqu'à 40% de la taille finale de l'infarctus [9].La nouvelle frontière dans la prise en charge de l’infarctus du myocarde aigu s’est déplacée du rétablissement rapide d’une reperfusion efficace de l’artère occluse, à la protection efficace du myocarde à risque de développer un infarctus dans le territoire en aval de l’occlusion. L’objectif est toujours de réduire la quantité finale de myocarde détruit de façon irréversible. Plusieurs études cliniques de phase II ont été réalisées afin de tester différentes interventions de cardioprotection pour réduire la taille de l'infarctus. Pour l'instant aucune technique n’a démontré son efficacité et/ou s’est avérée transposable à la prise en charge thérapeutique de routine des patients présentant un infarctus du myocarde aigu [10-12]. La recherche de nouvelles voies thérapeutiques pour traiter efficacement cet infarctus de reperfusion est donc un enjeu majeur.Références1. Hasdai D et al, 2002;2. Mandelzweig L et al, 20063. Friedrich MG et al, 20104. GibbonsRJ, JACC 2004.5. Lonborg J, Eur Heart J Card Imaging. 2013.6. Steg, Eur Heart J 2012.7. Reffelmann T et al. Basic Res Cardiol. 2006.
Published: 2017

49. Letter by Mewton and Croisille Regarding Article, 'Identification of High-Risk Patients After ST-Segment-Elevation Myocardial Infarction: Comparison Between Angiographic and Magnetic Resonance Parameters'

Author: Pierre Croisille, Nathan Mewton, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Coronary angiography, medicine.medical_specialty, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, ST segment, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Myocardial infarction, ComputingMilieux_MISCELLANEOUS, High risk patients, medicine.diagnostic_test, business.industry, Significant difference, Magnetic resonance imaging, medicine.disease, 3. Good health, Angiography, Cohort, Cardiology, Radiology, Cardiology and Cardiovascular Medicine, business
Abstract: We read with interest in this month’s issue of Circulation: Cardiovascular Imaging the article by Durante et al1 showing a significant difference between contrast-enhanced cardiac magnetic resonance and coronary angiography for the definition of microvascular obstruction. We had found similar results on a smaller cohort yet with an even greater difference between angiography contrast-enhanced cardiac …
Published: 2017

50. Strain analysis in CRT candidates using the novel segment length in cine (SLICE) post-processing technique on standard CMR cine images

Author: Cornelis P. Allaart, Alwin Zweerink, Albert C. van Rossum, Robin Nijveldt, Mathias Meine, Pierre Croisille, Patrick Clarysse, Joost P.A. Kuijer, Aernout M. Beek, Peter M. van de Ven, Li Na Wu, ICaR-VU, VU University Medical Center [Amsterdam], Department of Physics and Medical Technology, Vrije Universiteit Medical Centre (VUMC), Vrije Universiteit Amsterdam [Amsterdam] (VU)-Vrije Universiteit Amsterdam [Amsterdam] (VU), Department of Clinical Epidemiology and Biostatistics, Department of Cardiology, Utrecht University [Utrecht], RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales (MOTIVATE), Vrije Universiteit Medical Centre ( VUMC ), Vrije Universiteit Amsterdam [Amsterdam] ( VU ) -Vrije Universiteit Amsterdam [Amsterdam] ( VU ), 5 - RMN et optique : De la mesure aux biomarqueurs, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé ( CREATIS ), Hospices Civils de Lyon ( HCL ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Hospices Civils de Lyon ( HCL ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ), 1 - Imagerie et modélisation Vasculaires, Thoraciques et Cérébrales ( MOTIVATE ), Cardiology, ACS - Heart failure & arrhythmias, Amsterdam Neuroscience - Brain Imaging, Radiology and nuclear medicine, APH - Methodology, Epidemiology and Data Science, ACS - Atherosclerosis & ischemic syndromes, and ACS - Microcirculation
Subjects: Male, Intraclass correlation, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, medicine.medical_treatment, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Bundle-Branch Block, Cardiac resynchronization therapy, Magnetic Resonance Imaging, Cine, Cardiac Resynchronization Therapy (CRT), Myocardial tagging (CMR-TAG), [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, 030204 cardiovascular system & hematology, Ventricular Function, Left, 030218 nuclear medicine & medical imaging, Cardiac Resynchronization Therapy, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Segment length in cine (SLICE) technique, cardiovascular diseases, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Aged, Reproducibility, Strain (chemistry), Myocardial strain analysis, Left bundle branch block, business.industry, Patient Selection, Ultrasound, Segment length, Reproducibility of Results, General Medicine, Gold standard (test), Middle Aged, medicine.disease, Prognosis, Myocardial Contraction, cardiovascular system, Female, business, Nuclear medicine, Cardiac, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Biomarkers, circulatory and respiratory physiology, Cardiovascular magnetic resonance (CMR)
Abstract: Objectives Although myocardial strain analysis is a potential tool to improve patient selection for cardiac resynchronization therapy (CRT), there is currently no validated clinical approach to derive segmental strains. We evaluated the novel segment length in cine (SLICE) technique to derive segmental strains from standard cardiovascular MR (CMR) cine images in CRT candidates. Methods Twenty-seven patients with left bundle branch block underwent CMR examination including cine imaging and myocardial tagging (CMR-TAG). SLICE was performed by measuring segment length between anatomical landmarks throughout all phases on short-axis cines. This measure of frame-to-frame segment length change was compared to CMR-TAG circumferential strain measurements. Subsequently, conventional markers of CRT response were calculated. Results Segmental strains showed good to excellent agreement between SLICE and CMR-TAG (septum strain, intraclass correlation coefficient (ICC) 0.76; lateral wall strain, ICC 0.66). Conventional markers of CRT response also showed close agreement between both methods (ICC 0.61–0.78). Reproducibility of SLICE was excellent for intra-observer testing (all ICC ≥0.76) and good for interobserver testing (all ICC ≥0.61). Conclusions The novel SLICE post-processing technique on standard CMR cine images offers both accurate and robust segmental strain measures compared to the ‘gold standard’ CMR-TAG technique, and has the advantage of being widely available. Key Points • Myocardial strain analysis could potentially improve patient selection for CRT. • Currently a well validated clinical approach to derive segmental strains is lacking. • The novel SLICE technique derives segmental strains from standard CMR cine images. • SLICE-derived strain markers of CRT response showed close agreement with CMR-TAG. • Future studies will focus on the prognostic value of SLICE in CRT candidates. Electronic supplementary material The online version of this article (doi:10.1007/s00330-017-4890-0) contains supplementary material, which is available to authorized users.
Published: 2017

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