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Your search keyword '"Raffoux, Colette"' showing total 28 results
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4. HLA Association with Hematopoietic Stem Cell Transplantation Outcome: The Number of Mismatches at HLA-A, -B, -C, -DRB1, or -DQB1 Is Strongly Associated with Overall Survival

Author

Loiseau, Pascale, Busson, Marc, Balere, Marie-Lorraine, Dormoy, Anne, Bignon, Jean-Denis, Gagne, Katia, Gebuhrer, Lucette, Dubois, Valérie, Jollet, Isabelle, Bois, Monique, Perrier, Pascale, Masson, Dominique, Moine, Agnès, Absi, Léna, Reviron, Denis, Lepage, Virginia, Tamouza, Ryad, Toubert, Antoine, Marry, Evelyne, Chir, Zina, Jouet, Jean-Pierre, Blaise, Didier, Charron, Dominique, and Raffoux, Colette

Published
2007
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6. Allogeneic Marrow Stem-Cell Transplantation From Human Leukocyte Antigen–Identical Siblings Versus Human Leukocyte Antigen–Allelic–Matched Unrelated Donors (10/10) in Patients With Standard-Risk Hematologic Malignancy: A Prospective Study From the French Society of Bone Marrow Transplantation and Cell Therapy

Author

Yakoub-Agha, Ibrahim, Mesnil, Florence, Kuentz, Mathieu, Boiron, Jean Michel, Ifrah, Norbert, Milpied, Noel, Chehata, Sami, Esperou, Helene, Vernant, Jean-Paul, Michallet, Mauricette, Buzyn, Agnes, Gratecos, Nicole, Cahn, Jean Yves, Bourhis, Jean Henri, Chir, Zina, Raffoux, Colette, Socié, Gerard, Golmard, Jean Louis, and Jouet, Jean-Pierre

Published
2006
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11. Analysis of the French National Registry of unrelated bone marrow donors, using surnames as a tool for improving geographical localisation of HLA haplotypes.

Author

Degioanni, Anna, Darlu, Pierre, and Raffoux, Colette

Subjects
HLA histocompatibility antigens, BONE marrow, HAPLOIDY
Abstract

The first statistical analysis of the French National Registry of volunteer bone marrow donors estimated the probabilities of haplotype frequencies separately for each of the 20 administrative regions of France. Here we propose to use donors' surnames to increase the accuracy of location of the donor's geographical origin. This approach allows us to estimate haplotype frequencies for administrative entities (90 departments) smaller than regions and to correct for bias resulting from recent mobility. We analysed 30?777 donors typed for HLA-A,B and 17?745 donors typed for HLA-A,B,DR,DQ. By using the donors' surnames, we identified common and rare haplotypes (those found in only one department) and estimated the degree of HLA polymorphism at the department level. We also identified departments with a distinctive genetic structure (for example, Paris, Corsica, Pyrenees and Meurthe-et- Moselle). By providing a more accurate geographical distribution of HLA polymorphisms in France, this study will enable us to optimise policies for recruiting bone marrow donors and to improve the fit between the donor file and patients' needs.European Journal of Human Genetics (2003) 11, 794-801. doi:10.1038/sj.ejhg.5201038 [ABSTRACT FROM AUTHOR]

Published
2003
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12. Characterization of the human peripheral effector cells mediating antibody dependent cellular cytotoxicity against allogenic cells.

Author

Donner, Mireille, Raffoux, Colette, and Streiff, F.

Subjects
*CELL-mediated cytotoxicity, *CELL proliferation, *LEUCOCYTES, *CELL membranes, *LYMPHOCYTES, *NEUTROPHILS, *ELECTROPHORESIS, *CYTOLOGY
Abstract

The effector cell populations in human peripheral blood responsible for antibody-dependent cellular cytotoxicity against allogenic cells coated with HLA polyspecific antibodies were investigated using several separation techniques including preparative electrophoresis. Electrophoresis produced a marked effector cells enrichment in a range of 2-5 fractions which exhibited an intermediary electrophoretic mobility. Monocytic cells do not contribute an effector mechanism but minor subsets of polymorphonuclear cells and nylon wool non-adherent non-phagocytic lymphocytes displayed ADCC. Both effector cell populations were found to exhibit a similar electrical charge of cell surface centered around -1.05 μm · sec-1 V-1 cm. These observations provided a precise biophysical basis for the identification of effector cells in ADCC. [ABSTRACT FROM AUTHOR]

Published
1979

13. Influence of human leukocyte antigen genes on TCR V gene segment frequencies.

Author

Genevée, Catherine, Farçace, Françoise, Chung, Véronique, Dlu, Anita, Raffoux, Colette, Charron, Dominique, Hercend, Thierry, and Triebel, Frédéric

Abstract

Human leukocyte antigen (HLA)-dependent selection mechanisms exerted during thymic maturation are supposed to be main contributing factors to the genetic predetermination of the TCR repertoire and may have a detectable effect on adult peripheral blood lymphocyte V segment frequencies. Here, we analyzed whether polymorphic or non-polymorphic HLA determinants are associated with selected expression of some V gene segment specificities. We first examined the reactivity of 17 V segment specific mAb on purified CD4 and CD8 cell fractions in 10 unrelated people. We found a significant overexpression of only three V segment products (V2, V5.1 and V6.7) in CD4 and none in CD8 cell fractions in most individuals. Skewing of certain V segments by non-polymorphic HLA determinants (l.e. class II for CD4 and class I for CD8cells) is therefore more limited (3/17;) than previously thought Considering the effects of polymorphic HLA determinants, we compared TCR V segment frequencies in HLA-ldentical siblings to sibling pairs who differ at one or both HLA haplotypes, using 13 Vp specific mAb. In palrwise comparisons, we found that the HLA complex had no detectable effect on TCR repertoire in five large families with multiple siblings. Together, these observations suggest that HLA-predteted selection mechanisms exerted during thymic maturation might not have a predominant influence shaping the TCR repertoire of normal adults. [ABSTRACT FROM PUBLISHER]

Published
1994

17. Antithymocyte Globulins (ATG) as Part of the Myeloablative Conditioning (MAC) Regimen Can Reduce the Risk of Severe Graft-Vs.-Host Disease (GVHD) after Allogeneic Stem Cell Transplantation (allo-SCT) from Matched-Unrelated Donors (MUD).

Author

Mohty, Mohamad, Balere, Marie- Lorraine, Socie, Gerard, Milpied, Noel-Jean, Ifrah, Norbert, Kuentz, Mathieu, Harousseau, Jean-Luc, Vernant, Jean-Paul, Michallet, Mauricette, Buzyn, Agnes, Cahn, Jean-Yves, Bourhis, Jean-Henri, Blaise, Didier, Raffoux, Colette, Esperou, Helene, and Yakoub-Agha, Ibrahim

Published
2008
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18. Impact of HLA Allele Mismatch on the Outcome of Patients with Reduced-Intensity Allogeneic Haematopoietic Stem Cell Transplantation from Unrelated Donors: Analysis of 103 Patients of the French Registry.

Author

Toma, Andrea, Balere-Appert, Marie-Lorraine, Chir, Zina, Boiron, Jean-Michel, Bordigoni, Pierre, Socie, Gerard, Vernant, Jean-Paul, Renaud, Marc, Milpied, Noel-Jean, Michallet, Mauricette, Deconninck, Eric, Guyotat, Denis, Garban, Frederic, Sirvent, Anne, Contentin, Nathalie, Blaise, Didier, Raffoux, Colette, and Buzyn, Agnes

Published
2006
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19. Unrelated Allogeneic Stem Cell Transplantation for Severe Acquired Aplastic Anemia: Has Outcome Improved?.

Author

Maury, Sebastien, Balere-Appert, M.-Lorraine, Chir, Zina, Boiron, J.-Michel, Galambrun, Claire, Yakouben, Karima, Bordigoni, Pierre, Marie-Cardine, Aude, Milpied, Noel, Kanold, Justina, Maillard, Natacha, Bourhis, J.-Henri, Fischer, Alain, Lutz, Patrick, Michallet, Mauricette, Blaise, Didier, Cordonnier, Catherine, Raffoux, Colette, and Socie, Gerard

Published
2006
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23. Biological and Genetic Aspects of Donor-Recipient Matching in HSCT.

Author

Lange, Andrzej, Raffoux, Colette, and Shaw, Bronwen

Subjects
*STEM cell transplantation, *HEMATOPOIETIC stem cells
Abstract

An introduction is presented in which the editors discuss various topics within the issue including genetic and non-genetic factors which affect the outcome of the hematopoietic stem cell transplantation (HSCT).

Published
2012
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