23 results on '"Yang, Qi-Yuan"'
Search Results
2. In vitro and in vivo anticancer activity of novel Rh(III) and Pd(II) complexes with pyrazolopyrimidine derivatives
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Gu, Yun-Qiong, Ma, Meng-Xue, Yang, Qi-Yuan, Yang, Kun, Li, Huan-Qing, Hu, Mei-Qi, Liang, Hong, and Chen, Zhen-Feng
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- 2023
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3. Molecular cloning, tissue distribution, and pharmacologic function of melanocortin-3 receptor in common carp (Cyprinus carpio)
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Du, Yu-You, Yao, Ming-Xing, Yu, Hui-Xia, Mo, Hao-Lin, Yang, Qi-Yuan, Yu, Jia-Jia, Wang, Li-Xin, Zhou, Ji-Shu, and Li, Yang
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- 2023
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4. Molecular characterization and functional exploration of GPR84 in Chinese Giant Salamander (Andrias davidianus)
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Yu, Hui-Xia, Li, Yang, Ezeorba, Timothy, Mo, Hao-Lin, Zhang, Zhi-Hao, Yang, Qi-Yuan, and Wang, Li-Xin
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- 2022
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5. One-pot synthesis of oxoaporphines as potent antitumor agents and investigation of their mechanisms of actions
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Liao, Lan-Shan, Tan, Lin-Jie, Chen, Yin, Yang, Qi-Yuan, Choudhary, Muhammad Iqbal, Pan, Ying-Ming, Tang, Hai-Tao, Su, Gui-Fa, Liang, Hong, and Chen, Zhen-Feng
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- 2022
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6. Embryonic exposure to hyper glucocorticoids suppresses brown fat development and thermogenesis via REDD1
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Chen, Yan-Ting, Hu, Yun, Yang, Qi-Yuan, Liu, Xiang-Dong, Son, Jun Seok, de Avila, Jeanene M., Zhu, Mei-Jun, and Du, Min
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- 2021
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7. Synthesis, structural characterization and antitumor activity of six rare earth metal complexes with 8-hydroxyquinoline derivatives
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Yang, Qi-Yuan, Cao, Qian-Qian, Zhang, Yun-Liang, Xu, Xiao-Fang, Deng, Cai-Xing, Kumar, Rajesh, Zhu, Xiao-Min, Wang, Xiu-Jian, Liang, Hong, and Chen, Zhen-Feng
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- 2020
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8. Imprinted lncRNA Dio3os preprograms intergenerational brown fat development and obesity resistance
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Chen, Yan-Ting, Yang, Qi-Yuan, Hu, Yun, Liu, Xiang-Dong, de Avila, Jeanene M., Zhu, Mei-Jun, Nathanielsz, Peter W., and Du, Min
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- 2021
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9. Generalized Lieb-Schultz-Mattis theorem on bosonic symmetry protected topological phases
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Shenghan Jiang, Meng Cheng, Yang Qi, Yuan-Ming Lu
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Physics ,QC1-999 - Abstract
We propose and prove a family of generalized Lieb-Schultz-Mattis (LSM) theorems for symmetry protected topological (SPT) phases on boson/spin models in any dimensions. The "conventional" LSM theorem, applicable to e.g. any translation invariant system with an odd number of spin-1/2 particles per unit cell, forbids a symmetric short-range-entangled ground state in such a system. Here we focus on systems with no LSM anomaly, where global/crystalline symmetries and fractional spins within the unit cell ensure that any symmetric SRE ground state must be a nontrivial SPT phase with anomalous boundary excitations. Depending on models, they can be either strong or "higher-order" crystalline SPT phases, characterized by nontrivial surface/hinge/corner states. Furthermore, given the symmetry group and the spatial assignment of fractional spins, we are able to determine all possible SPT phases for a symmetric ground state, using the real space construction for SPT phases based on the spectral sequence of cohomology theory. We provide examples in one, two and three spatial dimensions, and discuss possible physical realization of these SPT phases based on condensation of topological excitations in fractionalized phases.
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- 2021
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10. Rhodium(III)–Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy.
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Gu, Yun-Qiong, Yang, Kun, Yang, Qi-Yuan, Li, Huan-Qing, Hu, Mei-Qi, Ma, Meng-Xue, Chen, Nan-Feng, Liu, Yang-Han, Liang, Hong, and Chen, Zhen-Feng
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- 2023
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11. Digital Subtraction Angiography-Guided Percutaneous Kyphoplasty in Treatment of Multi-Segmental Osteoporotic Vertebral Compression Fracture: A retrospective single-Center study.
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Tan, Bing, Yang, Qi-Yuan, Fan, Bin, Li, Qin, and Zhang, Xiao-Yan
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VERTEBROPLASTY ,VERTEBRAL fractures ,KYPHOPLASTY ,OSTEOPOROSIS ,DIGITAL subtraction angiography ,BONE cements - Abstract
Purpose: This study aimed to explore the effectiveness and safety of digital subtractionangiography (DSA)-guided percutaneous kyphoplasty (PKP) in treating multi-segmental osteoporotic vertebral compression fracture (OVCF). Methods: We retrospectively reviewed 68 patients with multi-segmental OVCF who had unilateral PKP surgeries using DSA and C arm guiding at our hospital between October 2016 and June 2020 and were followed for at least two years. All patients were divided into two groups: DSA guidance (n = 31) and C‐arm guidance (n=37). In addition, we collected the clinical and radiological evaluation results during postoperative and last follow-up periods. Results: Our findings revealed that the DSA guidance group required lesser time for channel establishment and surgery than the C-arm guidance group at P < 0.05. The incidences of bone cement leakage, fluoroscopy times, and radiation dose of the DSA guidance group were significantly lesser than the C‐arm guidance group (P < 0.05). Compared to the C-arm guidance group, the deviation of puncture in the DSA guidance group was significantly lower, the puncture angle in the DSA guidance group was significantly larger, and better bone cement distribution was obtained (P < 0.05). Compared to preoperative data, the VAS score, median vertebral height, and Cobb angle were significantly improved one day after surgery and the final follow-up in both groups (P < 0.05). However, the VAS score, the median vertebral height, average length of stay, and Cobb angle were not significantly different between the two groups (P > 0.05). Conclusion: DSA-guided PKP in treating multi-segmental OVCF can shorten the operation time, improve puncture accuracy, reduce the times and dose of fluoroscopy, reduce the leakage of bone cement, and achieve better cement distribution. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Arene‐Ruthenium(II)/Osmium(II) Complexes Potentiate the Anticancer Efficacy of Metformin via Glucose Metabolism Reprogramming.
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Yang, Qi‐Yuan, Ma, Rui, Gu, Yun‐Qiong, Xu, Xiao‐Fang, Chen, Zhen‐Feng, and Liang, Hong
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GLUCOSE metabolism , *ANTINEOPLASTIC agents , *BLOOD sugar , *LIVER metastasis , *METFORMIN , *METASTASIS - Abstract
Targeting metabolic reprogramming to treat cancer could increase overall survival and reduce side effects. Here, we put forward a strategy using arene‐ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming. Complexes 1–6 with oxoglaucine derivatives as ligands were synthesized and their anti‐tumor activities were tested under hypoglycemia. Results indicated that 2 and 5 potentiated the anticancer effects of Met. under hypoglycemia, exhibiting lower toxicity, slower blood glucose decline and inhibition of early tumor liver metastasis. Combination of 5 with Met. could be used as a new strategy to treat cancer under hypoglycemia through glucose metabolism reprogramming. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Maternal obesity induces epigenetic modifications to facilitate Zfp423 expression and enhance adipogenic differentiation in fetal mice
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Yang, Qi-Yuan, Liang, Jun-Fang, Rogers, Carl J., Zhao, Jun-Xing, Zhu, Mei-Jun, and Du, Min
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Obesity -- Complications and side effects -- Genetic aspects -- Research ,Fetus -- Growth ,Health - Abstract
Maternal obesity (MO) predisposes offspring to obesity and type 2 diabetes despite poorly defined mechanisms. Zfp423 is the key transcription factor committing cells to the adipogenic lineage, with exceptionally dense CpG sites in its promoter. We hypothesized that MO enhances adipogenic differentiation during fetal development through inducing epigenetic changes in the Zfp423 promoter and elevating its expression. Female mice were subjected to a control (Con) or obesogenic (OB) diet for 2 months, mated, and maintained on their diets during pregnancy. Fetal tissue was harvested at embryonic day 14.5 (E14.5), when the early adipogenic commitment is initiated. The Zfp423 expression was 3.6-fold higher and DNA methylation in the Zfp423 promoter was lower in OB compared with Con. Correspondingly, repressive histone methylation (H3K27me3) was lower in the Zfp423 promoter of OB fetal tissue, accompanied by reduced binding of enhancer of zeste 2 (EZH2). Gain- and loss-of-function analysis showed that Zfp423 regulates early adipogenic differentiation in fetal progenitor cells. In summary, MO enhanced Zfp423 expression and adipogenic differentiation during fetal development, at least partially through reducing DNA methylation in the Zfp423 promoter, which is expected to durably elevate adipogenic differentiation of progenitor cells in adult tissue, programming adiposity and metabolic dysfunction later in life. Diabetes 62:3727-3735, 2013, According to the latest National Health and Nutrition Examination Survey (NHANES; 2009-2010), 31.9% of nonpregnant women 20-39 years of age in the U.S. are obese, and another one-third are overweight [...]
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- 2013
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14. Ru(III) complexes with pyrazolopyrimidines as anticancer agents: bioactivities and the underlying mechanisms.
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Gu, Yun-Qiong, Shen, Wen-Ying, Yang, Qi-Yuan, Chen, Zhen-Feng, and Liang, Hong
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CYCLIN-dependent kinases ,DNA topoisomerase I ,ANTINEOPLASTIC agents ,LIVER cells ,CYTOCHROME c ,CELL cycle - Abstract
Three ruthenium(III) complexes with pyrazolopyrimidine [Ru(L
n )(H2 O)Cl3 ] (1–3, n = 1–3) were prepared and characterized. These Ru(III) compounds show strong cytotoxicity against six cancer cell lines and low toxicity to normal human liver cells. Particularly, they exhibited stronger cytotoxicity to SK-OV-3 cells than cisplatin. Mechanism studies revealed that complex 1 inhibited tumor cell invasion and suppressed cell proliferation, induced apoptosis by elevating the levels of intracellular ROS (reactive oxygen species) and free calcium (Ca2+ ), and reduced mitochondrial membrane potential (ΔΨ). It also activated the caspase cascade, accompanied with upregulation of cytochrome c, Bax, p53, Apaf-1 and downregulation of Bcl-2. Moreover, complex 1 caused cell cycle arrest at S phase by inhibiting the expression of CDC 25, cyclin A2 and CDK 2 proteins, and induced DNA damage by interacting with DNA and inhibiting the topoisomerase I enzyme. Complex 1 exhibited efficient in vivo anticancer activity in a model of SK-OV-3 tumor xenograft. [ABSTRACT FROM AUTHOR]- Published
- 2022
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15. Is It Necessary to Approach the Severe Osteoporotic Vertebral Biconcave-Shaped Fracture Bilaterally During the Process of PKP?
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Tan, Bing, Yang, Qi-Yuan, Fan, Bin, Lei, Chao, and Hu, Zhen-Ming
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VERTEBROPLASTY ,VERTEBRAL fractures ,KYPHOPLASTY ,OSTEOPOROSIS ,BONE cements ,STATURE ,RADIATION exposure - Abstract
Purpose: The goal of this study was to explore the outcomes of unilateral and bilateral approach percutaneous kyphoplasty (PKP) using CT-guidance in the treatment of severe osteoporotic single-level vertebral biconcave-shaped fracture. Methods: We retrospectively reviewed 89 patients with severe osteoporotic single-level vertebral biconcave-shaped fracture who had undergone unilateral and bilateral PKP surgeries using CT-guidance at our hospital between June 2013 and June 2019, and followed for at least 1 year. All patients were divided into unilateral (the transverse process-pedicle approach, n = 49) and bilateral (the pedicle approach, n = 40) groups. We collected the clinical and radiological evaluation results during postoperative and last follow-up periods. Results: Our findings revealed that the surgery time for the unilateral group was significantly shorter than that of the bilateral group at P < 0.05. The amount of bone cement and radiation exposure of the unilateral group were significantly lesser than that of the bilateral group (P < 0.05). Relative to preoperative data, the values of the VAS score and Oswestry disability index (ODI) were significantly improved at 1 day after surgery and the last follow-up in the two groups (P < 0.05). Notably, the median height of vertebra at 1 day after surgery and the last follow-up in the unilateral group was significantly restored than that of preoperative data (P < 0.05). However, the median height of vertebra at the same time intervals in the bilateral group showed no significant change compared with preoperative data (P > 0.05). Furthermore, the rate of bone cement leakage and incidence of adjacent-level vertebra fracture were not significantly different in the two groups (P > 0.05). Finally, both groups can obtain an asymmetrical distribution of bone cement in the vertebra. Conclusion: Compared to the bilateral PKP, unilateral PKP using CT-guidance in the treatment of the sOVBFs exhibits significantly shorter operation time, lesser radiation dose, and complications. Moreover, unilateral PKP can restore the median height of the vertebral body and eventually obtain a symmetrical distribution of bone cement in the vertebra. [ABSTRACT FROM AUTHOR]
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- 2021
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16. Excessive Glucocorticoids During Pregnancy Impair Fetal Brown Fat Development and Predispose Offspring to Metabolic Dysfunctions.
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Chen, Yan-Ting, Hu, Yun, Yang, Qi-Yuan, Son, Jun Seok, Liu, Xiang-Dong, de Avila, Jeanene M., Zhu, Mei-Jun, and Du, Min
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BROWN adipose tissue ,DNA methylation ,GLUCOCORTICOIDS ,DEXAMETHASONE ,PREGNANCY ,FETAL development ,PREGNANCY proteins - Abstract
Maternal stress during pregnancy exposes fetuses to hyperglucocorticoids, which increases the risk of metabolic dysfunctions in offspring. Despite being a key tissue for maintaining metabolic health, the impacts of maternal excessive glucocorticoids (GC) on fetal brown adipose tissue (BAT) development and its long-term thermogenesis and energy expenditure remain unexamined. For testing, pregnant mice were administered dexamethasone (DEX), a synthetic GC, in the last trimester of gestation, when BAT development is the most active. DEX offspring had glucose, insulin resistance, and adiposity and also displayed cold sensitivity following cold exposure. In BAT of DEX offspring, Ppargc1a expression was suppressed, together with reduced mitochondrial density, and the brown progenitor cells sorted from offspring BAT demonstrated attenuated brown adipogenic capacity. Increased DNA methylation in Ppargc1a promoter had a fetal origin; elevated DNA methylation was also detected in neonatal BAT and brown progenitors. Mechanistically, fetal GC exposure increased GC receptor/DNMT3b complex in binding to the Ppargc1a promoter, potentially driving its de novo DNA methylation and transcriptional silencing, which impaired fetal BAT development. In summary, maternal GC exposure during pregnancy increases DNA methylation in the Ppargc1a promoter, which epigenetically impairs BAT thermogenesis and energy expenditure, predisposing offspring to metabolic dysfunctions. [ABSTRACT FROM AUTHOR]
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- 2020
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17. AMP-activated protein kinase stimulates myostatin expression in C2C12 cells
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Das, Arun K., Yang, Qi-Yuan, Fu, Xing, Liang, Jun-Fang, Duarte, Marcio S., Zhu, Mei-Jun, Trobridge, Grant D., and Du, Min
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PROTEIN kinases , *MYOSTATIN , *GENE expression , *ENERGY metabolism , *SKELETAL muscle , *MUSCLE proteins , *MUSCLE growth - Abstract
Abstract: AMP-activated protein kinase (AMPK) is a master regulator of energy metabolism in skeletal muscle; AMPK induces muscle protein degradation but the underlying mechanisms are unclear. Myostatin is a powerful negative regulator of skeletal muscle mass and growth in mammalian species. We hypothesized that AMPK stimulates myostatin expression, which provides an explanation for the negative role of AMPK in muscle growth. The objective of this study is to demonstrate that AMPK stimulates myostatin expression using C2C12 cells as a model. Activation of AMPK by 5-aminoimidazole-4-carboxamide-1-β-d-riboruranoside (AICAR) dramatically increased the mRNA expression and protein content of myostatin in C2C12 myotubes, and to a lesser degree in myoblasts. Metformin, another AMPK activator, also stimulated myostatin expression at low concentrations. In addition, ectopic expression of AMPK wild-type α subunit (enhancing AMPK activity) and AMPK K45R mutant (knockdown AMPK activity) enhanced and reduced myostatin expression, respectively. These results indicate that AMPK stimulates myostatin expression in C2C12 cells, providing an explanation for the negative effect of AMPK on muscle growth. [Copyright &y& Elsevier]
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- 2012
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18. Unilateral biportal endoscopy vs. open decompression for lumbar epidural lipomatosis-cohort study using a prospective registry.
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Tan B, Zheng YH, Lei C, Ouyang JY, Wen YB, Shi ZH, and Yang QY
- Abstract
Objective: This study aimed to compare the outcomes of unilateral biportal endoscopy, unilateral laminectomy bilateral decompression (UBE-ULBD), and open lumbar decompression (OLD) in patients with lumbar epidural lipomatosis (LEL)., Methods: This prospective observational study was conducted from March 2019 to May 2022 and encompassed 33 patients with LEL who underwent lumbar decompression. The study included 15 cases of UBE-ULBD decompression and 18 cases of open decompression, which were followed up for 1 year. The baseline characteristics, initial clinical manifestations, and surgical details [including estimated blood loss (EBL) and preoperative complications] of all patients were recorded. Radiographic evaluation included the cross-sectional area (CSA) of the thecal sac and paraspinal muscles on MRI. Clinical results were analyzed using the Short Form-36 Score (SF-36), the Numeric Pain Rating Scale (NRS) for lumbar and leg pain, creatine kinase, the Roland and Morris Disability Questionnaire (RMDQ), and the Oswestry Disability Index (ODI)., Results: The dural sac CSA increased considerably at the 1-year postoperative follow-up in both groups ( p < 0.001). The operative duration in the OLD group (48.2 ± 7.2 min) was shorter than that in the UBE-ULBD group (67.7 ± 6.3 min, p < 0.001). The OLD group (97.2 ± 19.8 mL) was associated with more EBL than the UBE-ULBD group (40.6 ± 13.6 mL, p < 0.001). The duration of hospitalization in the OLD group (5.4 ± 1.3 days) was significantly longer compared with the UBE-ULBD group (3.5 ± 1.2 days, p < 0.01). The SF-36, NRS, RMDQ, and ODI scores improved in both groups postoperatively ( p < 0.001). Serum creatine kinase values in the UBE-ULBD group (101.7 ± 15.5) were significantly lower than those in the OLD group (330.8 ± 28.1 U/L) 1 day after surgery ( p < 0.001). The degree of paraspinal muscle atrophy in the UBE-ULBD group (4.81 ± 1.94) was significantly lower than that in the OLD group (12.15 ± 6.99) at 1 year ( p < 0.001)., Conclusion: UBE-ULBD and OLD demonstrated comparable clinical outcomes in treating LEL. However, UBE-ULBD surgery was associated with shorter hospital stays, lower rates of incision infection, lighter paravertebral muscle injury, and lower EBL than OLD surgery. Consequently, UBE-ULBD can be recommended in patients with LEL if conservative treatment fails., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Tan, Zheng, Lei, Ouyang, Wen, Shi and Yang.)
- Published
- 2024
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19. Decompression via unilateral biportal endoscopy for severe degenerative lumbar spinal stenosis: A comparative study with decompression via open discectomy.
- Author
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Tan B, Yang QY, Fan B, and Xiong C
- Abstract
Background: Previous studies have shown that the Unilateral Biportal Endoscopy is an effective and safety surgery for sufficient decompression of degenerative lumbar spinal stenosis. However, data are lacking in terms of its benefits when compared with conventional open lumbar discectomy (OLD), especially in patients with severe degenerative lumbar spinal stenosis (DLSS)., Aim: To compare the clini cal outcomes of two types decompressive surgery: unilateral biportal endoscopy-unilateral laminectomy bilateral decompression (UBE-ULBD) and conventional open lumbar discectomy (OLD) in severe degenerative lumbar spinal stenosis (DLSS)., Methods: We retrospectively analyzed patients who underwent UBE-ULBD ( n = 50, operated at 50 levels; UBE-ULBD group) and conventional open lumbar discectomy ( n = 59, operated at 47 levels; OLD group) between February 2019 and July 2021. All patients were diagnosed with severe stenosis based on the Schizas classification (Grade C or D) on MRI. We compared radiographic and clinical outcome scores [including the visual analog scale (VAS), Oswestry Disability Index (ODI), and Zurich Claudication Questionnaire (ZCQ)] between the 2 groups at 1 year of follow-up. The radiographic evaluation included the cross-sectional area (CSA) of the thecal sac and paraspinal muscles on MRI. Fasting blood was drawn before and 1 and 7 days after the operation to detect creatine kinase (CK). Surgical data perioperative complications were also investigated., Results: The baseline demographic data of the 2 groups were comparable, including VAS, ODI and ZCQ scores, the cross-sectional area of the thecal sac and paraspinal muscles and creatine kinase levels. The dural sac CSA significantly increased post -operatively in both groups, which confirmed they benefited from comparable decompressive effects. The operative duration in the OLD group was less than the UBE-ULBD group (43.9 ± 5.6 min vs. 74.2 ± 9.3 min, p < 0.05). The OLD group was associated with more estimated blood loss than the UBE-ULBD group (111.2 ± 25.0 ml vs. 41.5 ± 22.2 ml, P < 0.05). The length of hospital stay (HS) was significantly longer in the OLD group than in the UBE-ULBD group (6.8 ± 1.6 vs. 4.0 ± 1.4 days, P < 0.05). The VAS, ODI, and ZCQ scores improved in both groups after the operation. Serum creatine kinase values in the UBE-ULBD group were significantly lower than in the OLD group at 1 day after surgery (108. 1 ± 11.9 vs. 347.0 ± 19.5 U/L, P < 0.05). The degree of paraspinal muscle atrophy in the UBE-ULBD group was significantly lower than in the OLD group at 1 year (4.50 ± 0.60 vs. 11.42 ± 0.87, P < 0.05)., Conclusions: UBE-ULBD and conventional OLD demonstrate comparable short-term clinical outcomes in treating severe DLSS. However, UBE-ULBD surgery was associated with a shorter hospital stay, less EBL and paravertebral muscle injury than OLD surgery., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Tan, Yang, Fan and Xiong.)
- Published
- 2023
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20. Role of the mucin-like glycoprotein FCGBP in mucosal immunity and cancer.
- Author
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Liu Q, Niu X, Li Y, Zhang JR, Zhu SJ, Yang QY, Zhang W, and Gong L
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- Cell Adhesion Molecules metabolism, Humans, Immunity, Mucosal, Intestinal Mucosa, Proteins metabolism, Tumor Microenvironment, Mucins metabolism, Neoplasms metabolism
- Abstract
IgGFc-binding protein (FCGBP) is a mucin first detected in the intestinal epithelium. It plays an important role in innate mucosal epithelial defense, tumor metastasis, and tumor immunity. FCGBP forms disulfide-linked heterodimers with mucin-2 and members of the trefoil factor family. These formed complexes inhibit bacterial attachment to mucosal surfaces, affect the motility of pathogens, and support their clearance. Altered FCGBP expression levels may be important in the pathologic processes of Crohn's disease and ulcerative colitis. FCGBP is also involved in regulating the infiltration of immune cells into tumor microenvironments. Thus, the molecule is a valuable marker of tumor prognosis. This review summarizes the functional relevance and role of FCGBP in immune responses and disease development, and highlights the potential role in diagnosis and predicting tumor prognosis., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Liu, Niu, Li, Zhang, Zhu, Yang, Zhang and Gong.)
- Published
- 2022
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21. Ru(III) complexes with pyrazolopyrimidines as anticancer agents: bioactivities and the underlying mechanisms.
- Author
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Gu YQ, Shen WY, Yang QY, Chen ZF, and Liang H
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- Animals, Antineoplastic Agents chemistry, Apoptosis, Benzimidazoles, Calcium, Caspase 3 genetics, Caspase 3 metabolism, Caspase 9 genetics, Caspase 9 metabolism, Cell Cycle drug effects, Cell Line, Tumor, Cell Survival drug effects, Coordination Complexes chemistry, DNA Damage, Female, Gene Expression Regulation, Neoplastic drug effects, Mice, Mice, Inbred BALB C, Mitochondrial Membranes drug effects, Pyridines chemistry, Reactive Oxygen Species, Ruthenium Compounds chemistry, Xenograft Model Antitumor Assays, Antineoplastic Agents pharmacology, Coordination Complexes therapeutic use, Pyridines therapeutic use, Ruthenium Compounds therapeutic use
- Abstract
Three ruthenium(III) complexes with pyrazolopyrimidine [Ru(L
n )(H2 O)Cl3 ] (1-3, n = 1-3) were prepared and characterized. These Ru(III) compounds show strong cytotoxicity against six cancer cell lines and low toxicity to normal human liver cells. Particularly, they exhibited stronger cytotoxicity to SK-OV-3 cells than cisplatin. Mechanism studies revealed that complex 1 inhibited tumor cell invasion and suppressed cell proliferation, induced apoptosis by elevating the levels of intracellular ROS (reactive oxygen species) and free calcium (Ca2+ ), and reduced mitochondrial membrane potential (Δ Ψ ). It also activated the caspase cascade, accompanied with upregulation of cytochrome c , Bax, p53, Apaf-1 and downregulation of Bcl-2. Moreover, complex 1 caused cell cycle arrest at S phase by inhibiting the expression of CDC 25, cyclin A2 and CDK 2 proteins, and induced DNA damage by interacting with DNA and inhibiting the topoisomerase I enzyme. Complex 1 exhibited efficient in vivo anticancer activity in a model of SK-OV-3 tumor xenograft.- Published
- 2022
- Full Text
- View/download PDF
22. Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol.
- Author
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Yang QY, Cao QQ, Qin QP, Deng CX, Liang H, and Chen ZF
- Subjects
- Antineoplastic Agents chemistry, Apoptosis drug effects, Calcium metabolism, Caspases metabolism, Cell Cycle drug effects, Cell Cycle Proteins metabolism, Cell Line, Tumor, Coordination Complexes chemistry, Crystallography, X-Ray, Enzyme Activation drug effects, Humans, Hydrazones chemistry, Inhibitory Concentration 50, Intracellular Space metabolism, Membrane Potential, Mitochondrial drug effects, Reactive Oxygen Species metabolism, Solutions, Antineoplastic Agents chemical synthesis, Antineoplastic Agents pharmacology, Coordination Complexes chemical synthesis, Coordination Complexes pharmacology, Copper chemistry, Hydrazones chemical synthesis, Hydrazones pharmacology, Nickel chemistry
- Abstract
Two transition metal complexes with 2-((2-(pyridin-2-yl)hydrazono)methyl)quinolin-8-ol (L), [Cu(L)Cl₂]₂ ( 1 ) and [Ni(L)Cl₂]·CH₂Cl₂ ( 2 ), were synthesized and fully characterized. Complex 1 exhibited high in vitro antitumor activity against SK-OV-3, MGC80-3 and HeLa cells with IC
50 values of 3.69 ± 0.16, 2.60 ± 0.17, and 3.62 ± 0.12 μM, respectively. In addition, complex 1 caused cell arrest in the S phase, which led to the down-regulation of Cdc25 A, Cyclin B, Cyclin A, and CDK2, and the up-regulation of p27, p21, and p53 proteins in MGC80-3 cells. Complex 1 induced MGC80-3 cell apoptosis via a mitochondrial dysfunction pathway, as shown by the significantly decreased level of bcl-2 protein and the loss of Δψ, as well as increased levels of reactive oxygen species (ROS), intracellular Ca2+ , cytochrome C, apaf-1, caspase-3, and caspase-9 proteins in MGC80-3 cells.- Published
- 2018
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23. Zfp423 promotes adipogenic differentiation of bovine stromal vascular cells.
- Author
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Huang Y, Das AK, Yang QY, Zhu MJ, and Du M
- Subjects
- Animals, Azo Compounds, Blotting, Western, CCAAT-Enhancer-Binding Protein-alpha metabolism, Cattle, DNA Primers genetics, DNA-Binding Proteins genetics, Linear Models, Mice, PPAR gamma metabolism, Plasmids genetics, Real-Time Polymerase Chain Reaction, Receptor, Platelet-Derived Growth Factor alpha metabolism, Transcription Factors genetics, Transfection, Transforming Growth Factor beta metabolism, Adipogenesis physiology, Cell Differentiation physiology, DNA-Binding Proteins metabolism, Meat, Muscle, Skeletal cytology, Stromal Cells physiology, Transcription Factors metabolism
- Abstract
Intramuscular fat or marbling is critical for the palatability of beef. In mice, very recent studies show that adipocytes and fibroblasts share a common pool of progenitor cells, with Zinc finger protein 423 (Zfp423) as a key initiator of adipogenic differentiation. To evaluate the role of Zfp423 in intramuscular adipogenesis and marbling in beef cattle, we sampled beef muscle for separation of stromal vascular cells. These cells were immortalized with pCI neo-hEST2 and individual clones were selected by G418. A total of 288 clones (3×96 well plates) were isolated and induced to adipogenesis. The presence of adipocytes was assessed by Oil-Red-O staining. Three clones with high and low adipogenic potential respectively were selected for further analyses. In addition, fibro/adipogenic progenitor cells were selected using a surface marker, platelet derived growth factor receptor (PDGFR) α. The expression of Zfp423 was much higher (307.4±61.9%, P<0.05) in high adipogenic cells, while transforming growth factor (TGF)-β was higher (156.1±48.7%, P<0.05) in low adipogenic cells. Following adipogenic differentiation, the expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα) were much higher (239.4±84.1% and 310.7±138.4%, respectively, P<0.05) in high adipogenic cells. Over-expression of Zfp423 in stromal vascular cells and cloned low adipogenic cells dramatically increased their adipogenic differentiation, accompanied with the inhibition of TGF-β expression. Zfp423 knockdown by shRNA in high adipogenic cells largely prevented their adipogenic differentiation. The differential regulation of Zfp423 and TGF-β between low and high adipogenic cells is associated with the DNA methylation in their promoters. In conclusion, data show that Zfp423 is a critical regulator of adipogenesis in stromal vascular cells of bovine muscle, and Zfp423 may provide a molecular target for enhancing intramuscular adipogenesis and marbling in beef cattle.
- Published
- 2012
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