13 results on '"double-phase"'
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2. Partial regularity for steady double phase fluids
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3934/mine. and Bianca Stroffolini
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double-phase ,newtonian fluids ,morrey regularity ,Applied mathematics. Quantitative methods ,T57-57.97 - Abstract
We study partial Hölder regularity for nonlinear elliptic systems in divergence form with double-phase growth, modeling double-phase non-Newtonian fluids in the stationary case.
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- 2023
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3. Partial regularity for steady double phase fluids.
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Scilla, Giovanni and Stroffolini, Bianca
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NEWTONIAN fluids ,NON-Newtonian fluids ,MATHEMATICAL formulas ,MATHEMATICAL models ,MATHEMATICAL analysis - Abstract
We study partial Hölder regularity for nonlinear elliptic systems in divergence form with double-phase growth, modeling double-phase non-Newtonian fluids in the stationary case. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Existence of solutions for a double-phase variable exponent equation without the Ambrosetti-Rabinowitz condition
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Liu Jingjing and Pucci Patrizia
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double-phase ,variable exponent sobolev spaces ,critical points ,cerami condition ,primary 35j62 ,35j70 ,secondary 35j20 ,Analysis ,QA299.6-433 - Abstract
The article deals with the existence of a pair of nontrivial nonnegative and nonpositive solutions for a nonlinear weighted quasilinear equation in RN{{\mathbb{R}}}^{N}, which involves a double-phase general variable exponent elliptic operator A{\bf{A}}. More precisely, A{\bf{A}} has behaviors like ∣ξ∣q(x)−2ξ{| \xi | }^{q\left(x)-2}\xi if ∣ξ∣| \xi | is small and like ∣ξ∣p(x)−2ξ{| \xi | }^{p\left(x)-2}\xi if ∣ξ∣| \xi | is large. Existence is proved by the Cerami condition instead of the classical Palais-Smale condition, so that the nonlinear term f(x,u)f\left(x,u) does not necessarily have to satisfy the Ambrosetti-Rabinowitz condition.
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- 2023
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5. Detection of chronic obstructive pulmonary disease with deep learning using inspiratory and expiratory chest computed tomography and clinical information.
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Zhang Z, Wu F, Zhou Y, Yu D, Sun C, Xiong X, Situ Z, Liu Z, Gu A, Huang X, Zheng Y, Deng Z, Zhao N, Rong Z, He J, Xie G, and Ran P
- Abstract
Background: In recent years, more and more patients with chronic obstructive pulmonary disease (COPD) have remained undiagnosed despite having undergone medical examination. This study aimed to develop a convolutional neural network (CNN) model for automatically detecting COPD using double-phase (inspiratory and expiratory) chest computed tomography (CT) images and clinical information., Methods: A total of 2,047 participants, including never-smokers, ex-smokers, and current smokers, were prospectively recruited from three hospitals. The double-phase CT images and clinical information of each participant were collected for training the proposed CNN model which integrated a sequence of residual feature extracting blocks network (RFEBNet) for extracting CT image features and a fully connected feed-forward network (FCNet) for extracting clinical features. In addition, the RFEBNet utilizing double- or single-phase CT images and the FCNet using clinical information were conducted for comparison., Results: The proposed CNN model, which utilized double-phase CT images and clinical information, outperformed other models in detecting COPD with an area under the receiver operating characteristic curve (AUC) of 0.930 [95% confidence interval (CI): 0.913-0.951] on an internal test set (n=307). The AUC was higher than the RFEBNet using double-phase CT images (AUC =0.912, 95% CI: 0.891-0.932), single inspiratory CT images (AUC =0.888, 95% CI: 0.863-0.915), single expiratory CT images (AUC =0.897, 95% CI: 0.874-0.925), and FCNet using clinical information (AUC =0.805, 95% CI: 0.777-0.841). The proposed model also achieved the best performance on an external test (n=516) with an AUC of 0.896 (95% CI: 0.871-0.931)., Conclusions: The proposed CNN model using double-phase CT images and clinical information can automatically detect COPD with high accuracy., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-24-367/coif). The authors have no conflicts of interest to declare., (2024 AME Publishing Company. All rights reserved.)
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- 2024
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6. On the uniqueness for weak solutions of steady double-phase fluids
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Abdelwahed Mohamed, Berselli Luigi C., and Chorfi Nejmeddine
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uniqueness ,double-phase ,steady motion ,non-newtonian fluid ,76a05 ,35j62 ,35q30 ,35j25 ,35j55 ,Analysis ,QA299.6-433 - Abstract
We consider a double-phase non-Newtonian fluid, described by a stress tensor which is the sum of a p-Stokes and a q-Stokes stress tensor, with 1 2 to justify calculations for weak solutions. Results are obtained through a careful use of the symmetries of the convective term and are also valid for rather general (even anisotropic) stress-tensors.
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- 2021
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7. On a class of quasilinear problems with double-phase reaction and indefinite weight.
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ONETE, FLORIN-IULIAN
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NONLINEAR equations ,CRITICAL point (Thermodynamics) ,ELLIPTIC equations - Abstract
We study a nonlinear eigenvalue problem which is perturbed by a term with double-phase growth. The main result establishes the existence of at least two nontrivial weak solutions in the case of high perturbations of the parameter. The proof combines variational tools with the Pucci-Serrin three critical points theorem. [ABSTRACT FROM AUTHOR]
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- 2019
8. Highly-parallelized simulation of a pixelated LArTPC on a GPU
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DUNE Collaboration
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multiplication and induction ,pulse formation ,scintillation ,tutkimuslaitteet ,hiukkasfysiikka ,electric fields ,noble liquid detectors ,charge transport ,detector modelling and simulations II ,simulation methods and programs ,Monte Carlo -menetelmät ,ilmaisimet ,electron emission ,double-phase ,prosessointi ,ionization ,algoritmit ,time projection chambers ,simulointi ,TPC - Abstract
The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype. peerReviewed
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- 2023
9. In vitro culture systems and acclimatization of Aechmea setigera Mart. ex Schult. & Schult. f. (Bromeliaceae)
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Janaína Medeiros Vasconcelos, João Ricardo Avelino Leão, Andrea Raposo, and Paulo Cesar Poeta Fermino Junior
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bromeliad ,culture medium ,micropropagation ,double-phase ,Agriculture (General) ,S1-972 - Abstract
Aechmea setigera is an endemic bromeliad from Amazon with ornamental potential. Bromeliads have been propagated by tissue culture. The consistency of the culture medium in vitro multiplication influences the rate of propagation. In this sense, the objective of this study was to evaluate different culture systems with the use of 6-benzylaminopurine (BAP) on in vitro propagation and the effect of different substrates in acclimatization of plantlets Aechmea setigera. In vitro germinated seedlings were inoculated in MS medium in liquid stationary, semisolid, double-phase systems, plus 6-benzylaminopurine (BAP) in different concentrations (0, 2.2, 4.4, 8.8 and 17.7 μM). The ex vitro rooting and acclimatization were performed on substrate Plantmax Forest ®, vermiculite and sawdust eucalyptus. After three successive subcultures, the double-phase system showed a higher number of regenerated shoots in comparison to other systems. Acclimatization using the combination of commercial substrate Plantmax Forest ® and vermiculite favored the growth of micropropagated plants. The use of a culture medium double-phase without growth regulator, and the rooting in acclimatization are feasible strategy for the micropropagation of A. setigera. Indexação
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- 2015
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10. On the uniqueness for weak solutions of steady double-phase fluids
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Luigi C. Berselli, Mohamed Abdelwahed, and Nejmeddine Chorfi
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Physics ,QA299.6-433 ,Uniqueness, double-phase, steady motion, non-Newtonian fluid ,Mathematical analysis ,35j55 ,non-Newtonian fluid ,35j62 ,Non-Newtonian fluid ,steady motion ,76a05 ,Double phase ,35j25 ,35q30 ,double-phase ,Uniqueness ,Analysis - Abstract
We consider a double-phase non-Newtonian fluid, described by a stress tensor which is the sum of a p-Stokes and a q-Stokes stress tensor, with 1 pqp, q), we prove the uniqueness of small solutions. We use the p q > 2 to justify calculations for weak solutions. Results are obtained through a careful use of the symmetries of the convective term and are also valid for rather general (even anisotropic) stress-tensors.
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- 2022
11. The Electronics, Trigger and Data Acquisition System for the Liquid Argon Time Projection Chamber of the DarkSide-50 Search for Dark Matter
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A. Nelson, M. Carlini, K. Arisaka, E. V. Hungerford, G. Fiorillo, W. Bonivento, P. N. Singh, C. Dionisi, L. Pagani, M. D'Incecco, S. Luitz, Chung-Yao Yang, A. Sotnikov, A. V. Derbin, D. A. Semenov, Augusto Brigatti, H. Qian, K. Fomenko, F. Budano, I. N. Machulin, T. Miletic, N. Canci, Marco Pallavicini, P. Trinchese, C. Giganti, E. Edkins, D. D'Angelo, R. Saldanha, R. Tartaglia, An. Ianni, B. R. Hackett, Hui Wang, A. Zec, S. Pordes, F. Di Eusanio, B. Bottino, P. J. Mosteiro, Fausto Ortica, Thomas Alexander, A. Monte, M. Rescigno, B. Baldin, Anton Empl, A. K. Alton, S. Parmeggiano, Michele Montuschi, Aldo Romani, G. De Rosa, A. Razeto, S. De Cecco, M. M. Wojcik, G. K. Giovanetti, A. de Candia, E. Pantic, P. Agnes, B. J. Mount, F. Gabriele, Q. Riffard, A. Oleinik, B. Schlitzer, D. Franco, M. Orsini, T. N. Johnson, M. Ave, C. Savarese, R. B. Vogelaar, Monica Verducci, C. Zhu, W. Zhong, P. Cavalcante, Nicomede Pelliccia, J. Maricic, Giuseppe Longo, D. Montanari, D. Sablone, C. J. Martoff, G. Bonfini, B. Reinhold, Sandra Zavatarelli, G. Zuzel, Ivone F. M. Albuquerque, E. Shields, V. N. Muratova, K. Biery, Yanchu Wang, K. J. Keeter, Frank Calaprice, S. Davini, D. M. Asner, X. Xiang, Vittorio Cataudella, Samuele Sangiorgio, A. Tonazzo, Stefano Giagu, A. L. Renshaw, A. Navrer Agasson, A. M. Goretti, G. Korga, Paolo Musico, A. Fan, D. A. Pugachev, F. Granato, M. Cariello, Stefano Maria Mari, M. D. Skorokhvatov, L. Grandi, K. Herner, G. Di Pietro, Yanhui Ma, A. Candela, S. Catalanotti, Stuart Derek Walker, A. G. Cocco, Jingke Xu, A. A. Machado, Min-Xin Guan, K. Pelczar, Cristiano Galbiati, D. Hughes, M. De Deo, J. Tatarowicz, A. S. Kubankin, M. De Vincenzi, Gioacchino Ranucci, C. L. Kendziora, Irina James, M. Caravati, Mariano Cadoni, N. Rossi, G. Forster, L. Crippa, O. Smirnov, M. Gromov, P. D. Meyers, M. Wada, E. V. Unzhakov, Y. Guardincerri, M. E. Monzani, A. Pocar, P. Saggese, V. Bocci, M. Cadeddu, C. Cicalo, Giovanni Covone, Severino Angelo Maria Bussino, K. Randle, A. Vishneva, X. Li, M. Razeti, J. Yoo, B. Loer, H. Cao, S. Odrowski, G. Testera, Y. Suvorov, S. Westerdale, A. S. Chepurnov, C. Stanford, Denis Korablev, J. Brodsky, P. Humble, A. Devoto, S. D. Rountree, Paolo Lombardi, E. Segreto, A. Mandarano, V. V. Kobychev, W. Sands, L. Marini, M. Bossa, B. Rossi, Alan Watson, M. Lissia, G. De Filippis, Xiang Xiao, R. Milincic, G. Koh, Henning O. Back, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), DarkSide, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie ( APC - UMR 7164 ), Centre National de la Recherche Scientifique ( CNRS ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Laboratoire de Physique Nucléaire et de Hautes Énergies ( LPNHE ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Agnes, P., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Arisaka, K., Asner, D. M., Ave, M., Back, H. O., Baldin, B., Biery, K., Bocci, V., Bonfini, G., Bonivento, W., Bossa, Maria, Bottino, B., Brigatti, A., Brodsky, J., Budano, F., Bussino, S., Cadeddu, M., Cadoni, M., Calaprice, F., Canci, N., Candela, A., Cao, H., Caravati, M., Cariello, M., Carlini, M., Catalanotti, S., Cataudella, V., Cavalcante, P., Chepurnov, A., Cicaló, C., Cocco, A. G., Covone, G., Crippa, L., D'Angelo, D., D'Incecco, M., Davini, S., de Candia, A., Cecco, S. De, Deo, M. De, Filippis, G. De, Rosa, G. De, Vincenzi, M. De, Derbin, A., Devoto, A., Eusanio, F. Di, Dionisi, C., Pietro, G. Di, Edkins, E., Empl, A., Fan, A., Fiorillo, G., Fomenko, K., Forster, G., Franco, D., Gabriele, F., Galbiati, C., Giagu, S., Giganti, C., Giovanetti, G. K., Goretti, A. M., Granato, F., Grandi, L., Gromov, M., Guan, M., Guardincerri, Y., Hackett, B. R., Herner, K. R., Hughes, D., Humble, P., Hungerford, E. V., Ianni, A., James, I., Johnson, T. N., Keeter, K., Kendziora, C. L., Kobychev, V., Koh, G., Korablev, D., Korga, G., Kubankin, A., Li, X., Lissia, M., Loer, B., Lombardi, P., Longo, G., Luitz, S., Ma, Y., Machado, A., Machulin, I. N., Mandarano, A., Mari, S. M., Maricic, J., Marini, L., Martoff, C. J., Meyers, P. D., Miletic, T., Milincic, R., Montanari, D., Monte, A., Montuschi, M., Monzani, M. E., Mosteiro, P., Mount, B. J., Muratova, V. N., Musico, P., Agasson, A. Navrer, Nelson, A., Odrowski, S., Oleinik, A., Orsini, M., Ortica, F., Pagani, L., Pallavicini, M., Pantic, E., Parmeggiano, S., Pelczar, K., Pelliccia, N., Pocar, A., Pordes, S., Pugachev, D. A., Qian, H., Randle, K., Ranucci, G., Razeti, M., Razeto, A., Reinhold, B., Renshaw, A. L., Rescigno, M., Riffard, Q., Romani, A., Rossi, B., Rossi, N., Rountree, S. D., Sablone, D., Saggese, P., Saldanha, R., Sands, W., Sangiorgio, S., Savarese, C., Schlitzer, B., Segreto, E., Semenov, D. A., Shields, E., Singh, P. N., Skorokhvatov, M. D., Smirnov, O., Sotnikov, A., Stanford, C., Suvorov, Y., Tartaglia, R., Tatarowicz, J., Testera, G., Tonazzo, A., Trinchese, P., Unzhakov, E. V., Verducci, M., Vishneva, A., Vogelaar, R. B., Wada, M., Walker, S., Wang, H., Wang, Y., Watson, A. W., Westerdale, S., Wojcik, M. M., Xiang, X., Xiao, X., Xu, J., Yang, C., Yoo, J., Zavatarelli, S., Zec, A., Zhong, W., Zhu, C., Zuzel, G., Bossa, M., De Candia, A., De Cecco, S., De Deo, M., De Filippis, G., De Rosa, Gianfranca, De Vincenzi, M., Di Eusanio, F., Di Pietro, G., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Universidade de São Paulo = University of São Paulo (USP), University of Massachusetts [Amherst] (UMass Amherst), University of Massachusetts System (UMASS), Fermi National Accelerator Laboratory (Fermilab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), ANR-10-LABX-0023,UnivEarthS,Earth - Planets - Universe: observation, modeling, transfer(2010), and ANR-11-IDEX-0005,USPC,Université Sorbonne Paris Cité(2011)
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axions ,Physics - Instrumentation and Detectors ,data acquisition ,Noble liquid detectors (scintillation, ionization, double-phase) ,01 natural sciences ,Dark Matter, DarkSide Detector, TPC ,High Energy Physics - Experiment ,Dark Matter detectors (WIMPs, axions, etc.) ,High Energy Physics - Experiment (hep-ex) ,Data acquisition ,Noble liquid detectors (scintillation ,etc.) ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,[ PHYS.PHYS.PHYS-INS-DET ] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Instrumentation ,Mathematical Physics ,Physics ,Resistive touchscreen ,Time projection chamber ,photomultiplier ,Instrumentation and Detectors (physics.ins-det) ,double-phase) ,amplifier ,Cryostat ,Photomultiplier ,FOS: Physical sciences ,chemistry.chemical_element ,Optics ,[ PHYS.HEXP ] Physics [physics]/High Energy Physics - Experiment [hep-ex] ,0103 physical sciences ,ionization ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,010306 general physics ,background: radioactivity ,noble liquid detectors ,scintillation ,double-phase ,Dark Matter detectors (WIMPs ,MESH: LArTPC ,Argon ,010308 nuclear & particles physics ,business.industry ,Amplifier ,Voltage divider ,dark matter: detector ,trigger ,time projection chamber: liquid argon ,Gran Sasso ,chemistry ,electronics: readout ,business ,electronics: design - Abstract
The DarkSide-50 experiment at the Laboratori Nazionali del Gran Sasso is a search for dark matter using a dual phase time projection chamber with 50 kg of low radioactivity argon as target. Light signals from interactions in the argon are detected by a system of 38 photo-multiplier tubes (PMTs), 19 above and 19 below the TPC volume inside the argon cryostat. We describe the electronics which processes the signals from the photo-multipliers, the trigger system which identifies events of interest, and the data-acquisition system which records the data for further analysis. The electronics include resistive voltage dividers on the PMTs, custom pre-amplifiers mounted directly on the PMT voltage dividers in the liquid argon, and custom amplifier/discriminators (at room temperature). After amplification, the PMT signals are digitized in CAEN waveform digitizers, and CAEN logic modules are used to construct the trigger, the data acquisition system for the TPC is based on the Fermilab "artdaq" software. The system has been in operation since early 2014., 24 pages
- Published
- 2017
12. Phase and microstructure evolution of 0.2Zr1-xCexO2/Zr1-yCeySiO4 (0 ≤ x + y ≤ 1) ceramics designed to immobilize tetravalent actinides.
- Author
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Ding, Yi, Jiang, Zhengdi, Xiong, Tianheng, Bai, Zimei, Zhao, Dandan, Dan, Hui, and Duan, Tao
- Subjects
- *
RADIOACTIVE wastes , *MICROSTRUCTURE , *LATTICE constants , *CERAMICS , *GRAIN size - Abstract
Zircon is important ceramic used widely due to its excellent properties, in particular for nuclear waste immobilization. However, it is difficult to obtain mono-phase zircon with high yield, usually result in double-phase ZrO 2 /ZrSiO 4 ceramics. Herein, Ce-doped double-phase 0.2Zr 1- x Ce x O 2 /Zr 1- y Ce y SiO 4 (0 ≤ x + y ≤ 1) ceramics were fabricated and their phase and microstructure evolution were studied. The results demonstrated that Ce content has great influence on the phase composition and microstructure. The ceramics with 0 ≤ x + y < 0.1 are tetragonal-ZrSiO 4 , monoclinic-ZrO 2 and tetragonal-ZrO 2 phases, with 0.1 ≤ x + y ≤ 0.3 are tetragonal-ZrSiO 4 , monoclinic-ZrO 2 , tetragonal-ZrO 2 and cubic-ZrO 2 phases, with 0.3 < x + y ≤ 0.6 are tetragonal-ZrSiO 4 , tetragonal-ZrO 2 and cubic-ZrO 2 phases, and with 0.6 < x + y ≤ 1 are cubic-ZrO 2 and Ce 2 Si 2 O 7 phases. With increasing Ce-doping content, the ZrSiO 4 retained the tetragonal phase, while ZrO 2 transformed from monoclinic to stable cubic phase. Furthermore, lattice parameters, grain size and compactness increased with increasing Ce content. Image 1 • Ce-doped double-phase 0.2Zr 1- x Ce x O 2 /Zr 1- x Ce x SiO 4 (0≤ x ≤ 1) ceramics were fabricated. • Effect of Ce content on the phase and microstructure evolution was elucidated. • ZrSiO 4 retained tetragonal, while ZrO 2 transformed from monoclinic to cubic. • Lattice parameters increased with Ce-doping, revealing lattice immobilization of Ce. • Grain size and compactness increased with increasing Ce content. [ABSTRACT FROM AUTHOR]
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- 2020
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13. Value of I-123-subtraction and single-photon emission computed tomography in addition to planar Tc-99m-MIBI scintigraphy before parathyroid surgery
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Francisca H. Jorna, Pieter L. Jager, Clara Lemstra, John T. M. Plukker, TH Que, Damage and Repair in Cancer Development and Cancer Treatment (DARE), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)
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Parathyroidectomy ,Male ,Technetium Tc 99m Sestamibi ,subtraction technique ,medicine.medical_specialty ,TC-99M-SESTAMIBI SCINTIGRAPHY ,SESTAMIBI SCINTIGRAPHY ,medicine.medical_treatment ,PERSISTENT HYPERPARATHYROIDISM ,Single-photon emission computed tomography ,Scintigraphy ,Diagnosis, Differential ,hyperparathyroidism ,Preoperative Care ,medicine ,Humans ,PRIMARY HYPERPARATHYROIDISM ,radionuclide imaging ,Retrospective Studies ,Observer Variation ,Tomography, Emission-Computed, Single-Photon ,Hyperparathyroidism ,medicine.diagnostic_test ,Parathyroid neoplasm ,business.industry ,food and beverages ,Reproducibility of Results ,General Medicine ,Middle Aged ,SUBTRACTION SCINTIGRAPHY ,medicine.disease ,PREOPERATIVE LOCALIZATION ,SECONDARY HYPERPARATHYROIDISM ,Parathyroid Neoplasms ,99M SESTAMIBI ,SPECT ,Surgery ,Female ,Radiology ,Tomography ,Radiopharmaceuticals ,business ,Nuclear medicine ,Primary hyperparathyroidism ,Emission computed tomography ,DOUBLE-PHASE - Abstract
Purpose. To find out if single-photon emission computed tomography (SPECT) and I-123-subtraction can enhance the findings of Tc-99-methoxyisobutylisonitrile (MIBI) scintigraphy for the preoperative localization of parathyroid (PT) tumors.Methods. Among the 111 consecutive patients who underwent preoperative planar Tc-99-MIBI scintigraphy for hyperparathyroidism (HPT), 64 underwent delayed SPECT, and 17 underwent I-123-subtraction. Two independent blinded experts scored the topographical localization, diagnostic confidence, and impact of each diagnostic modality on the surgical strategy.Results. For adenomas, Tc-99-MIBI scintigraphy had a sensitivity of 77% with a positive predictive value (PPV) of 83%. SPECT did not affect the sensitivity or PPV, but it increased the diagnostic confidence and changed the surgical strategy in 21% of the patients. I-123-subtraction increased the sensitivity from 64% to 82%, but decreased the PPV from 88% to 82%. In hyperplastic glands, Tc-99-MIBI scintigraphy had a sensitivity of 47% and a PPV of 95%. When Tc-99-MIBI scintigraphy was combined with SPECT and I-123-subtraction, the results were 44%/10% and 52%/92%, respectively. Both SPECT and I-123-subtraction decreased the diagnostic confidence.Conclusions. Adding SPECT to Tc-99-MIBI scintigraphy improved the surgical decision for parathyroid adenomas. The addition of I-123-subtraction was of limited value. For hyperplastic glands, Tc-99-MIBI scintigraphy was relatively ineffective, even with the addition of SPECT or I-123-subtraction.
- Published
- 2007
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