Big Data optimizes the process of information processing, expands the scale of information processing, and improves the application effect of big data and computer information technology. However, big data has also triggered data leakage, network viruses and other security risks. In the context of big data, in order to give full play to the application advantages of computer information security technology, it is necessary to give full play to all kinds of technology to avoid the problems such as system failures, external attacks and so on, then ensure that the computer system in a safe and stable operating environment. This paper analyzes the problems of computer information security technology under the background of big data, and puts forward the corresponding application strategies based on the concrete superiority technology.