9 results on '"Csonka, Tamás"'
Search Results
2. Rituximabkezelés idiopathiás inflammatorikus myopathiákban
- Author
-
BODOKI Levente, VINCZE Melinda, GRIGER Zoltán, CSONKA Tamás, CSERI Karolina, HORTOBÁGYI Tibor, DANKÓ Katalin, Hortobágyi Tibor (1965-) (patológus), Pathológiai Intézet -- 30, Neuropathológiai Nem Önálló Tanszék -- 137, ÁOK -- OEC, and Debreceni Egyetem
- Subjects
magyar nyelvű folyóiratközlemény hazai lapban - Published
- 2013
3. [The role of carbonic anhydrase IX in the progression of malignant tumors - a potential therapeutic target?]
- Author
-
Matolay O, Bádon SE, Balázs L, Juhász P, Csonka T, and Méhes G
- Subjects
- Animals, Carbonic Anhydrase IX metabolism, Cell Hypoxia, Cell Line, Tumor, Cell Proliferation, Humans, Antigens, Neoplasm, Neoplasms drug therapy
- Abstract
Insufficient tissue perfusion in malignancies results in hypoxic areas, favoring neoplastic progression. Tumor cells under hypoxia undergo an adaptive program by activating alternative metabolic pathways, which is regulated by hypoxia inducible factor-1 (HIF1) in order to overcome microenvironmental changes. The expression of carbonic anhydrase IX (CAIX) is a prominent protective mechanism against intracellular acidosis occurring in cancer cells suffering from hypoxia. Due to the activity of CAIX, the restored intracellular pH (pHi) supports tumor cell proliferation and migration, while the compensatory extracellular acidosis contributes to immunoprotection and to chemo- and radioresistance. In vitro and animal model experiments showed that the chemotherapeutic efficiency could be significantly improved by the selective inhibition of CAIX, thus, its adjuvant therapeutic potential is under active investigation.
- Published
- 2021
4. [MOLECULAR PATHOLOGY OF MENINGIOMAS].
- Author
-
Murnyák B, Csonka T, and Hortobágyi T
- Subjects
- Brain Neoplasms genetics, Brain Neoplasms pathology, CpG Islands genetics, DNA Methylation genetics, Gene Expression Regulation, Neoplastic genetics, Humans, Loss of Heterozygosity, Meningeal Neoplasms therapy, Meningioma therapy, MicroRNAs genetics, Neoplasm Grading, Neoplasm Recurrence, Local genetics, Neoplasm Recurrence, Local pathology, Pathology, Molecular, Prognosis, Risk Factors, Epigenesis, Genetic genetics, Genes, Neoplasm genetics, Meningeal Neoplasms genetics, Meningeal Neoplasms pathology, Meningioma genetics, Meningioma pathology, Mutation
- Abstract
Meningiomas represent nearly one-third of all adult primary brain tumours. According to their clinical and histologic appearance, they can be divided into WHO grades I-III. Almost 90% of meningiomas are benign, showing favourable response to conventional therapies, however, patients diagnosed with grade 2 and 3 tumours may have a poor prognosis. In addition, high frequency of tumour recurrence renders treatments more challenging even in benign meningiomas. Molecular-pathological profiling of meningiomas could lead to development of more effective therapies. Although the cytogenetic background of these tumours are already well-characterised, the majority of related genes and mutations is still unknown. Recently, high-throughput techniques enabled better characterisation of mechanisms involved in meningioma development, progression and recurrence. Furthermore, epigenetic dysregulation could offer new opportunities for both diagnosis and treatment of meningiomas. We provide a comprehensive overview of cytogenetic and molecular genetic defects as well as epigenetic alterations in meningiomas. Many of these may serve as biomarker or therapeutic target in the near future.
- Published
- 2015
- Full Text
- View/download PDF
5. [Inclusion body myositis].
- Author
-
Bodoki L, Vincze M, Griger Z, Csonka T, Dankó K, and Hortobágyi T
- Subjects
- Adenosine Triphosphatases genetics, Aged, Cell Cycle Proteins genetics, Diagnosis, Differential, Female, Frontotemporal Dementia genetics, Humans, Mutation, Missense, Prognosis, Valosin Containing Protein, Frontotemporal Dementia diagnosis, Myositis, Inclusion Body diagnosis, Myositis, Inclusion Body epidemiology, Myositis, Inclusion Body genetics, Myositis, Inclusion Body pathology, Myositis, Inclusion Body physiopathology
- Abstract
The idiopathic inflammatory myopathies are systemic, chronic autoimmune diseases characterized by proximal symmetrical muscle weakness. One of the main diseases in this group is inclusion body myositis (IBM), an underdiagnosed, progressive muscle disease characteristically affecting the middle-aged and older population. It has a slow, relentlessly progressive course. The precise pathogenesis of the disease remains unknown. In most of the cases it is diagnosed a few years after the appearance of the first symptoms. The muscle biopsy typically shows endomysial inflammation, with invasion of mononuclear cells into the non-necrotic fibers, and also rimmed vacuoles. It appers, that both inflammation and degeneration are present at the onset of the disease. Our aim is to raise awareness about this disease which leads to severe disability, with clinicopathological case presentations and literature overview, emphasizing the importance of collaboration between the clinician and the neuropathologist. No effective therapy is currently available but the rapid diagnosis is essential to slow disease progression. Although this is a relatively rare disease, patients are presenting not only in immunology outpatient clinics; our reports aims to raise awareness and facilitate accurate early diagnosis of IBM.
- Published
- 2015
6. [Anti-signal recognition particle autoantibody positive myopathy].
- Author
-
Bodoki L, Vincze M, Hortobágyi T, Griger Z, Csonka T, and Dankó K
- Subjects
- Aged, Biopsy, Child, Humans, Male, Necrosis, Polymyositis immunology, Polymyositis pathology, Signal Recognition Particle metabolism, Autoantibodies blood, Muscle Weakness immunology, Muscle Weakness pathology, Signal Recognition Particle immunology
- Abstract
Idiopathic inflammatory myopathies are systemic, autoimmune diseases characterized by proximal symmetrical muscle weakness. We review the myositis-associated and myositis-specific autoantibodies, among them the anti-SRP autoantibody. Among those autoimmune myopathy cases, that are associated with autoantibodies, we can detect anti-SRP autoantibody positive myositis cases. We describe the role of signal recognition particle, its structure and role in protein biosynthesis. We review how necrotizing autoimmune myopathy is identified, and the differences from classical polymyositis. The anti-SRP titer correlates with disease activity. We present some cases to show how the disease appears in childhood and also some rare cases from the literature. Finally we present a case to draw attention to the importance of this disease.
- Published
- 2014
7. [The diagnosis of herpes encephalitis--a case-based update].
- Author
-
Csonka T, Szepesi R, Bidiga L, Péter M, Klekner A, Hutóczky G, Csiba L, Méhes G, and Hortobágyi T
- Subjects
- Adult, Algorithms, Cerebral Hemorrhage virology, Delayed Diagnosis, Diagnosis, Differential, Encephalitis, Herpes Simplex complications, Encephalitis, Herpes Simplex pathology, Fatal Outcome, Fever virology, Humans, Immunohistochemistry, Interdisciplinary Communication, Magnetic Resonance Imaging, Male, Necrosis virology, Polymerase Chain Reaction, Seizures virology, Simplexvirus immunology, Temporal Lobe pathology, Time Factors, Antiviral Agents administration & dosage, Cerebrospinal Fluid virology, Encephalitis, Herpes Simplex diagnosis, Encephalitis, Herpes Simplex drug therapy, Simplexvirus isolation & purification, Temporal Lobe virology
- Abstract
Herpes simplex virus encephalitis (HSVE) is a rare and life-threatening infection. The clinical signs are diverse and often misleading regarding the aetiology. However, focal seizure with fever and typical CT/MRI finding should always raise the possibility of HSVE as early diagnosis and antiviral therapy is crucial. Before the advent of molecular techniques and high-tech imaging histological examination from multiple brain biopsies were often necessary. Although nowadays PCR and other molecular methods may provide an aetiological diagnosis some cases need neuropathological verification. Due to the high IgG seropositivity rate in the population the plasma IgG titer is not diagnostic and elevation of its plasma level requires several weeks. We report the case of a 25-years old male patient who initially presented with epileptic seizures. There was no final diagnosis and no causal treatment in the district general hospital. The patient was admitted to our institution in comatose state on day 9; the initiated diagnostic tests and therapy could not save the patient who died next day. The autopsy and subsequent neuropathological examination revealed HSVE. We present a flowchart on diagnostic work-up and special techniques to aid diagnosis in suspected viral encephalitis.
- Published
- 2013
8. [Occurrence and molecular pathology of high grade gliomas].
- Author
-
Murnyák B, Csonka T, Hegyi K, Méhes G, Klekner A, and Hortobágyi T
- Subjects
- Adult, Age Factors, Aged, Astrocytoma epidemiology, Astrocytoma pathology, Brain Neoplasms genetics, Cytogenetic Analysis, Female, Glioblastoma epidemiology, Glioblastoma pathology, Glioma genetics, Gliosarcoma epidemiology, Gliosarcoma pathology, Humans, Hungary epidemiology, Incidence, Male, Middle Aged, Neoplasm Grading, Oligodendroglioma epidemiology, Oligodendroglioma pathology, Pathology, Molecular, Sex Factors, Brain Neoplasms epidemiology, Brain Neoplasms pathology, Glioma epidemiology, Glioma pathology, Mutation
- Abstract
Background: Glial tumours represent the most frequent type of primary brain cancers. Gliomas are characterized by heterogeneity that makes the diagnosis, histological classification and the choosing of correct therapy more difficult. Despite the advances in developing therapeutic strategies patients with malignant gliomas have a poor prognosis; therefore glial tumours represent one of the most important areas of cancer research. There are no detailed data on the epidemiology of gliomas in Hungary., Methods: In the first section of our publication, we analysed the histological diagnosed cases between 2007 and 2011 at the Institute of Pathology, University of Debrecen Medical and Health Science Centre. We analyzed the incidence of 214 high-grade gliomas by tumor grades, gender, age, and the anatomical localization., Results: The majority of cases were glioblastoma (182 cases), and the remaining 32 cases were anaplastic gliomas. The mean age of patients was 57 years (+/- 16.4), and the male:female ratio was 1.1:1. The most frequent area of tumors was the frontal lobe followed by the temporal, parietal and occipital lobe. We include new findings published recently about glioma pathogenesis, molecular pathways, mutant genes and chromosomal regions. We explain briefly the role of selected important genes in glioma genesis and give an update on knowledge provided by modern molecular methods, which could beneficially influence future therapy and the diagnosis of gliomas.
- Published
- 2013
9. [Occurrence and molecular pathology of low grade gliomas].
- Author
-
Murnyák B, Csonka T, Klekner A, and Hortobágyi T
- Subjects
- Adult, Age Factors, Aged, Astrocytoma epidemiology, Astrocytoma pathology, Brain Neoplasms genetics, Cytogenetic Analysis, Female, Gene Deletion, Glioma genetics, Humans, Hungary epidemiology, Incidence, Male, Middle Aged, Neoplasm Grading, Oligodendroglioma epidemiology, Oligodendroglioma pathology, Sex Factors, Brain Neoplasms epidemiology, Brain Neoplasms pathology, Glioma epidemiology, Glioma pathology, Mutation
- Abstract
Background: The WHO grade I. and II. low-grade gliomas represent nearly the 15% of all primary brain tumors. These tumours contain clinically, histologically and molecularly distinct tumor types. According to their histologic characteristic, grade II glial tumours are the diffuse astrocytoma, oligodendroglioma and oligoastrocytoma subgroups; ependymal tumors are not included in this study., Methods: In our publication, we analysed the histologically diagnosed glioma cases between 2007 and 2011 at our institution., Results: Low-grade gliomas were diagnosed in 127 cases (62 male / 65 female), and the mean ages were 39 years (+/- 20.3). More than half of the cancers were localized in the frontal lobe, and the second most frequent area was the temporal lobe. Finally, we complete our report with an overview of major molecular pathways in low-grade gliomas.
- Published
- 2013
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.