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3. [Preparation of some pyrido (2,3-e)-1,4-diazepines].

Author

Carboni S, Da Settimo A, Bertini D, Ferrarini PL, Livi O, and Tonetti I

Subjects
Animals, Azepines pharmacology, Cardiovascular System drug effects, Central Nervous System drug effects, Drug Evaluation, Preclinical, Indicators and Reagents, Magnetic Resonance Spectroscopy, Pyridines pharmacology, Spectrophotometry, Infrared, Azepines chemical synthesis, Pyridines chemical synthesis
Abstract

By treating pyrido (2,3-e)-1,4-diazepinones with alkyl halides, N4-alkylpyrido (2,3-e)-1,4-diazepines were obtained. In addition a number of N1-alkylpyrido (2,3-e)-1,4-diazepines were prepared from alkyltetrahydronaphthyridinones by the Schmidt reaction. Preliminary pharmacological screening of some of these compounds showed no appreciable activity.

Published
1976
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4. [Synthesis and biological activity of pyrido(2,3-e)-1,4-diazepine and of pyrido(2,3-b)(1,4)diazepine].

Author

Carboni S, Da Settimo A, Bertini D, Ferrarini PL, Livi O, and Tonetti I

Subjects
Antifungal Agents, Azepines pharmacology, Cardiovascular System drug effects, Central Nervous System drug effects, Chemical Phenomena, Chemistry, Drug Evaluation, Preclinical, Pyridines chemical synthesis, Pyridines pharmacology, Azepines chemical synthesis
Abstract

The Schmidt reaction on tetrahydro-1,8-naphthyridin-4-ones gave pyrido [2,3-e]-1,4-diazepines and pyrido[2,3-b][1,4]diazepines. The preliminary pharmacological screening of some of these compounds showed no appreciable activity.

Published
1975

5. [Preparation and pharmacological study of some N-substituted amino-1,8-naphthyridines].

Author

Carboni S, Da Settimo A, Bertini D, Ferrarini PL, Livi O, and Tonetti I

Subjects
Amines chemical synthesis, Amphetamine antagonists & inhibitors, Analgesics chemical synthesis, Animals, Anti-Inflammatory Agents, Antifungal Agents, Bacteria drug effects, Drug Evaluation, Preclinical, Mice, Naphthyridines chemical synthesis, Naphthyridines pharmacology
Abstract

The synthesis of N-substituted amino-1,8-naphthyridines is described. Some products were subyected to pharmacological screening and the resulting data are reported.

Published
1975

6. [Preparation and pharmacological study of some 1,2,3-triazol-1,8-naphthyridine derivatives].

Author

Carboni S, Da Settimo A, Ferrarini PL, and Livi O

Subjects
Animals, Anti-Infective Agents, Anti-Inflammatory Agents, Non-Steroidal, Antifungal Agents, Antiprotozoal Agents, Behavior, Animal drug effects, Drug Evaluation, Preclinical, Mice, Naphthyridines pharmacology, Naphthyridines toxicity, Rats, Structure-Activity Relationship, Triazoles pharmacology, Triazoles toxicity, Naphthyridines chemical synthesis, Triazoles chemical synthesis
Published
1978

7. [Synthesis and biological activity of some 1,8-naphthyridines].

Author

Carboni S, Da Settimo A, Bertini D, Ferrarini PL, Livi O, and Tonetti I

Subjects
Bacteria drug effects, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Spectrophotometry, Infrared, Naphthyridines chemical synthesis, Naphthyridines pharmacology
Published
1973

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