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Background and Objective: Vincristine is an important anticancer drug, which is highly toxic to the liver. It is a naturally occurring polyphenol found in many plants. Some studies have shown the anti-inflammatory and antioxidant effects of resveratrol. This study was conducted to determine the hepatoprotective and antioxidant effects of resveratrol against vincristine-induced toxicity in mice. Methods: In this experimental study, 32 female NMRI mice weighing 25-30 grams were randomly divided into four groups (n=8): control, vincristine, vincristine + resveratrol, and resveratrol. The animals received vincristine intraperitoneally at a dose of 3 mg/kg/bw once a week for four weeks. They also received resveratrol at a dose of 30 mg/kg for 28 days through gastric gavage. At the end of the study, the activity of alanine transaminase (ALT) and aspartate transaminase (AST) were measured. The level of antioxidant enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPX), malondialdehyde (MDA) as well as total antioxidant capacity (TAC) was measured in the liver tissue of mice. Results: The activities of ALT, AST, SOD, and GPX decreased in the vincristine group compared to the control group, while MDA level increased significantly (P˂0.05). Treatment with resveratrol in the vincristine + resveratrol group improved the evaluated parameters compared to the vincristine group (P˂0.05). Conclusion: Resveratrol has protective and antioxidant effects against vincristine-induced oxidative damage in the liver of mice. [ABSTRACT FROM AUTHOR]

Background Aging is associated with metabolic disorders. Although the beneficial effects of exercise and resveratrol consumption in the health of the elderly has been reported, the combined effect of intermittent swimming and resveratrol consumption on the antioxidant system in liver tissue is not clear yet. Objective This study aims to investigate the combined effect of intermittent swimming and resveratrol consumption on the expression of superoxide dismutases (SOD), glutathione peroxidase (GPx), and Malondialdehyde (MDA) in the liver tissue of older rats. Methods In this experimental study, 32 elder rats were divided into four groups: control, swimming, resveratrol and swimming+resveratrol. The resveratrol (100 mg) dissolved in 1% methylcellulose was administrated daily by gavage. The swimming was performed at three sessions per week. The GPx and SOD expression levels were measured by real-time polymerase chain reaction method, and the MDA level was measured by ELISA method. Results The GPx level in the swimming+resveratrol group were significantly higher than in the control (P=0.001), resveratrol (P=0.04) and swimming (P=0.002) groups. MDA levels in the resveratrol (P=0.001), swimming (P=0.001) and swimming+resveratrol (P=0.001) groups were significantly lower than in the control group; in the swimming+resveratrol group, it was significantly lower than the resveratrol (P=0.001) and swimming (P=0.009) groups. Conclusion It seems that intermittent swimming and resveratrol consumption have favorable effects on improving the antioxidant defense system and lipid peroxidation in liver tissue. Therefore, it is recommended to use intermittent swimming and resveratrol to prevent liver damage in the elderly. [ABSTRACT FROM AUTHOR]

Background and purpose: Resveratrol (RSV) is a naturally polyphenolic compound found in grapes and other plant sources. It has potent free radical scavenger and antioxidative properties.The aim of this study was to evaluate the protective effect of resveratrol against Perfluorooctanoic acid (PFOA) induced mitochondrial toxicity in isolated liver mitochondria. Materials and methods: Mitochondria were isolated from fresh male rat’s liver tissues using differential centrifugation technique. Then, the isolated mitochondria were divided into the following groups: control, PFOA (1mM), PFOA plus RSV (50, 100, and 200 µM), and PFOA plus Vit C (positive control). The effects of PFOA were assessed on a series of mitochondrial parameters including mitochondrial function, reactive oxygen species (ROS) formation, lipid peroxidation (LPO), protein carbonyl, and glutathione (GSH) content. Data were analyzed using GraphPad Prism version 6. Results: PFOA induced mitochondrial dysfunction in isolated liver mitochondria. Resveratrol markedly alleviated mitochondrial dysfunction-induced by PFOA in isolated liver mitochondria. Conclusion: Resveratrol showed protective effect against PFOA induced hepatotoxicity which may be attributed to its antioxidant activity. So, it can be considered as an effective supplement against oxidative stress and mitochondrial dysfunction induced by PFOA exposure in isolated liver mitochondria. [ABSTRACT FROM AUTHOR]

Non-Alcoholic Fatty Liver (NAFLD) is produced by liver pathological accumulation of fat and the prevalence of this disorder in the world is 35-36%. Evidence has shown that auxiliary treatments, including the use of antioxidant compounds, can be effective in improving nonalcoholic fatty liver. Resveratrol is a polyphenolic compound that has antioxidant properties. Other mechanisms of resveratrol have been shown to improve fatty liver. Study Type: A systematic Review on Randomized Clinical Trials. This study aimed to investigate the results of research on the relationship between supplementation of resveratrol and non-alcoholic fatty liver. Randomized Clinical Trials on the effect of supplementation of resveratrol on NAFLD from PubMed, Scopus, ISI and Google Scholar databases between 2000 and 2018 with the keywords: Resveratrol, Fatty Liver, Nonalcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis, NAFLD Reviewed. Between most clinical trials have shown positive effects of resveratrol supplementation on the improvement of non-alcoholic fatty liver symptoms, including oxidative stress, inflammation, liver enzymes, and insulin resistance. There was also a decrease in fat content in the subjects. However, some studies have different results and do not show a significant effect on resveratrol supplementation. In most studies, the positive effects of resveratrol supplementation on non-alcoholic fatty liver have been proven, but more studies are needed because of the controversy of the study. [ABSTRACT FROM AUTHOR]

Introduction: Oxidative stress is an important issue in the reduction of recovery rate of bypass patients. Antioxidant supplements have a pivotal role on modifying oxidative stress and inflammation in these patients. In the current study attempts have been made to investigate the synergistic effects of taking Resveratrol supplement with selective exercise recovery training on the lipid profile of patients. Methods: In a randomized clinical trial study, among 85 patients referred to the Farshchian Cardiovascular Subspecialty University Hospital, who undergoing coronary artery bypass graft surgery and had not chest angina symptom during exercise test, 40 voluntary subjects were entered into the study and randomly assigned to the four groups: Resveratrol supplement consumption (RSC; n=10), Resveratrol supplement with rehabilitation (RSR; n=10), rehabilitation exercise training (RET; n=10), and control (Con; n=10). The selective sports exercises program lasted for eight weeks. Treatment sessions were organized three secessions for every other day during eight weeks, while supplement group subjects received 400 mg/day resveratrol. Blood sample was taken before exercise training and after 48 hours. Very low density lipoprotein (VLDL), Low density lipoprotein (LDL), triglyceride (TG), and cholesterol (CHOL) concentration were measured. Analysis of covariance was used for data analyzing and 0.05 was considered as a level of significance Results: Results showed that TG and CHOL concentration improved in the RET, RSR, and RSC than control (p≤0.05), while there was no significant difference between RET, RSR, and RSC (P˃0.05). There is a significant LDL change in RET than control (P=0.046). Also HDL contrarian in RSR was greater than control (P=0.007). Conclusion: It can be said that combined reasveratrol and selective exercise rehabilitation training could improve some lipid profiles and it is more effective than just exercise training rehabilitation and Resveratrol supplement on lipid profiles. [ABSTRACT FROM AUTHOR]