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The aimed to report the occurrence of uterine serosal inclusion cysts in bitches and queens, as well as describe their macroscopic and microscopic aspects. Were used 200 uteri (100 bitches and 100 queens) coming from elective ovariohysterectomy. The pieces were fixed in a solution of 10% buffered formaldehyde, followed by routine histologic processing, with slides stained with hematoxylin and eosin. The studied animals were classified according to species, age, parity and use of contraceptives. Data were statistically analyzed using Chi-square test with a significance level of 5%. Of the uteri analyzed 7% Bitches and 1% of queens showed uterine serosal inclusion cysts, with no statistically significant difference interspecies for age, parity and use of contraceptives. Macroscopically, were observed single cystic dilations localized in myometrial region or on serosal surface of the uterus. When cut, observed a serous fluid content. Histologically, cystic dilations were located between the myometrium and perimetrium or just in myometrial layer. The internal liner of the cysts was composed of varying cubic epithelium, columnar, squamous, stratified or mixed. It was concluded that the uterine serosal inclusion cysts is a pathological change with low incidence in bitches and queens, causing irregularity in the uterine surfasse because the formation of cysts and has a wide range of internal epithelial lining. [ABSTRACT FROM AUTHOR]

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Primary ocular tumors are the most common specially in the uvea. Furthermore, secondary malignancies are described. Uveal benign and malignant melanocytic tumors benign and malignant tumors are the most common in dogs. We conducted a retrospective study of cases of cancer involving the eye in dogs, diagnosed by the service of Animal Pathology, UNESP-Botucatu from January 1999 to June 2013. We observed the occurrence of the seven cases, with the majority of cases in adult, female, mongrel dogs with primary diffuse intraocular melanoma. The diagnosis by histopathology and immunohistochemistry is essential for lesion characterization and prognosis. [ABSTRACT FROM AUTHOR]

Cirrhosis is the final stage of chronic hepatitis occurring diffusely in the liver, characterized by destruction of hepatic parenchymal cells, accompanied by increased fibrous tissue. A female of the species Geochelone carbonaria, approximately 16 years old, with a history of anorexia, lethargy, constant urination and watery stools for a period of 4 days of evolution and after death. At necropsy was observed, liver, firm irregular surface, the presence of diffuse nodules coalescing to about 0.5 cm to 4 cm, varying in color from yellow to light red, occupying all liver lobes. Histopathological examination of liver fragments revealed liver tissue architecture disorganized, intense proliferation of connective tissue enclosing "islands" of hepatocytes with vacuolated cytoplasm intensely and offset from the nucleus to the periphery (degeneration and necrosis). Histopathological findings and revealed the diagnosis of cirrhosis in Geochelone carbonaria. [ABSTRACT FROM AUTHOR]

Currently there are a large number of cases of neoplasms related in canine species, and the breast of the higher incidence in bitches. Although biopsy is recommended as definitive diagnosis, cytology has shown good agreement cyto-histopathology. The purpose of this study was to determine the accuracy of the cytopathological test in the diagnosis of mammary tumors, whose method involves procedure safer, less invasive and faster results. We analyzed the histology and cytology of 32 breast tumors. The cytopathology was carried out by applying the method fine needle aspiration cytology and the results analyzed using the confirmatory diagnostic histopathology. This study revealed accuracy of 79.31% and sensitivity of 96.4% of cytopathology test, whose values are similar to more recent works. The cytopathology applied as a diagnostic means for mammary tumors in dogs, particularly in relation to the determination of malignancy shown to be effective. However, the test still requires a standardized microscopic analysis. [ABSTRACT FROM AUTHOR]

The purpose of this study was to evaluate the role of bacterial and viral agents in cattle abortions from farms of the southern region of Minas Gerais State, through a retrospective and prospective study of abortion cases received by the Setor de Patologia, from the Universidade Federal de Lavras by histopathological, immunohistochemical and microbiological exams. Of the 30 fetuses with microscopic lesions, eight had lesions consistent with bacterial agents and three with viral agents. The etiologic agents diagnosed were Brucella sp, Leptospira sp, Staphylococcus sp and bovine herpesvirus. [ABSTRACT FROM AUTHOR]

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases regulated by endogenous tissue inhibitors of metalloproteinases (TIMPs). TIMP-1 is overexpressed in several types of human neoplasms. Tissue expression of TIMP-1 was evaluated in 41 samples of canine cutaneous mast cell tumors. The percentage of immuno-positive cells for TIMP-1 was compared with histopathological grading. The cytoplasmic expression of TIMP-1 in mast cells were positive (100%) of tumors examined. The mast cell classified as less differentiated by Patnaik showed higher expression of TIMP-1 (P <0.05 between stages I and III). These results suggest that expression of TIMP-1 may be a potential prognostic marker for the canine cutaneous mast cell tumors. [ABSTRACT FROM AUTHOR]

This paper evaluates Neospora caninum as an agent responsible for bovine abortion in rural properties in the southern region of Minas Gerais State by histopathology, immunohistochemistry and molecular analyses. The data was obtained from retrospective and prospective study of abortions received by the Veterinary Pathology Section of the Federal University of Lavras. From 30 fetuses that had microscopic lesions, 19 had lesions consistent with N. caninum. In 14 the diagnoses was confirmated. These findings demonstrate that N. caninum is the main agent associated with bovine abortions in the studied region and that the combination of diagnostic techniques was essential for final diagnosis. [ABSTRACT FROM AUTHOR]

This study aimed to identify and classify the canine transmissible venereal tumor (TVT) for the pattern predominant cellular subtypes in linfocitoide, plasmacytoid and mixed by cytological and histopathological examinations in 20 samples of dogs with primary genital neoplasia. Subsequently, the animals underwent chemotherapy with vincristine sulphate and verified the relationship between these subtypes and therapeutic response. Microscopic cytology samples allowed a better characterization of the cell type. Regarding the classification of the TVT, the plasmacytoid type was the most frequent, followed by linfocitoide and mixed. Regarding treatment, the animals needed an average of four to five chemotherapy for remission of the neoplastic mass, except for a dog carrier TVT plasmacytoid which received seven applications. It is inferred that the TVT plasmacytoid subtype present greater resistance to anticancer therapy. [ABSTRACT FROM AUTHOR]

The pathogenesis of Equine Herpesvirus type 1 (EHV-1) was valuated in hamsters(Mesocricetus auratus) inoculated by intranasal way for Brazilian strains A4/72,A9/92, A3/97, ISO 72/10 and Argentine AR4. There was acute evolution, with weight loss in the 3rd day post-inoculation (3rd d.p.i.), except to A9/92 (2nd d.p.i.). Neurological and respiratory symptoms were observed in the 2nd d.p.i. to A9/92 and in the 3rd d.p.i in the others. The histopathology revealed in the CNS congested meninges with mononuclear infiltrate, multifocal areas of hemorrhage in the neuropil, necrosis with mononuclear infiltrate and intranuclear eosinophilic inclusions in neurons and glial cells; in the lungs a discrete and diffuse infiltrate mainly mononuclear; intranuclear eosinophilic inclusions in syncytia and epithelia were observed only in ISO 72/10 and AR4. Hamsters inoculated with strain A9/922 presented more acute symptoms, and more severe pulmonary and cerebral histopathological lesions, suggesting this strain to be more virulent than the others. [ABSTRACT FROM AUTHOR]

Infectious epididymitis is considered a major cause of economic losses for the sheep industry worldwide. It is caused mainly by Brucella ovis, Actinobacillus seminis, and Histophilus somni. This study aimed to investigate histopathological changes associated with experimental infection with H. somni in rams. Ten rams with 18 to 24 months, were infected by intra-epididymal inoculation with H. somni. Eight rams inoculated with H. somni became infected. Five rams had at least one positive organ by bacteriology. Microscopically, the main lesions were observed inflammatory changes in the genitourinary tract and testicular degeneration. H. somni was able of causing infection, colonizing several organs of the genitourinary tract, however, laboratorial diagnostic techniques are required for direct confirmation of the etiologic agent. [ABSTRACT FROM AUTHOR]

Nonhuman primates are important for comparative studies including infection by Helicobacter spp. The cynomolgus monkey (Macaca fascicularis) is one of the most used primate as animal models. The aim of this study was to identify the presence of Helicobacter spp. by histolopathologic examination, using the silver impregnation method (Warthin-Starry - WS technique). Gastric samples were collected from cardia, body, fundus, antrum, and pylorus of 8 cynomolgus monkeys. The samples were processed for histopathologic examination. All 8 stomachs (100%) were positive for Helicobacter spp. in the test used. The antrum was the gastric region with the highest frequency of infection identified (8/8 - 100% positive samples). Then came body (7 - 88%), pyloric (5 - 63%), fundic (4 - 50%), and cardia regions (2 - 25%). The data showed the presence of Helicobacter spp. in the gastric mucosa from laboratory monkeys and also confirmed the efficiency of the Warthin-Starry staining method for detection of gastric spiral bacteria. [ABSTRACT FROM AUTHOR]

Deoxynivalenol (DON) and nivalenol (NIV) are trichothecenes mycotoxins produced by Fusarium species, naturally co-occuring in food and feed. The gastrointestinal tract represents the first barrier as well as the first target for these toxicants. The aim of the present study was to characterize the effects of DON and NIV, alone or in combination, on the intestinal tissue of pig. Crossbreed weanling piglets of 24 days-old (n = 6) were used for explanting jejunal tissue. Explants were exposed to 0.1; 0.3; 1; 3 e 10 e 30μM of DON or NIV, or of the mixture DON+NIV (1:1) for 4 hours. The individual treatment with the mycotoxins DON and NIV resulted in a significant decrease of the histopathological score from doses of 10μM and 1μM, respectively. The DON+NIV combination demonstrated synergism for IC50 whereas antagonism was observed at the lower doses. The present results suggest that Fusarium toxins alone may not predict their effects in environment where the combinations of toxins are frequently observed. The present study indicates that the effects of the association of mycotoxins are not similar to the isolated effects, parameters that consider multi-contamination, which are common in natural contaminations, have to be established. [ABSTRACT FROM AUTHOR]

Siparuna guianensis is used for muscle pain and diuretic, was reported by livestock producers from Tocantins state as toxic and abortifacient. The aim of this study was to assess the subchronic toxicity of the crude extract of the leaves of Siparuna guianensis (EBSG) in rats. Males rats were divided into groups: experimental (n = 15) that received 10% EBSG in dimethylsulfoxide (DMSO) solution at 20% and the control group that received only vehicle, for 60 days. The dose corresponded to that if the plant was the only food. At the end of the experimental period heart, lung, spleen, liver, kidneys, adrenals, thymus, brain, testis and epididymis were collected for histopathological analysis and organ weights. It was concluded that the 10% EBSG did not promote toxicity recognizable by histopathology examination. Key words: negramina; plant, rat [ABSTRACT FROM AUTHOR]

Several efforts have been directed towards a better understanding of breast tumors, aiming to obtain a therapeutic success and an increased survival of patients, which includes the determination of biomarkers. Previous studies indicate that the anti-inflammatory protein annexin A1 (ANXA1) acts in different signaling pathways in cancer, associated to the regulation of apoptosis, migration and invasion of cancer cells. Thus, it is important to perform studies to understand the role of ANXA1 in canine mammary neoplasia. For this purpose, 37 dog mammary tissue samples were collected, histopathologically classified and submmited to immunohistochemistry with anti-ANXA1. The results showed a decrease in the expression of ANXA1 associated to a worse prognosis of the tumor, corroborating to previous findings in human breast cancer. This study suggests that ANXA1 is functionally involved in the progression of canine mammary tumors, and may play a role as an additional biomarker in determining the prognosis of these tumors. [ABSTRACT FROM AUTHOR]

Cerebellum lesions in guinea pigs fed with Astragalus pehuenches were determined. Control Group (CG, n=2), Treated Group 33% (TG33%, n=3) and Treated Group 50% (TG50%, n=3) were established. The percentages correspond to the A. pehuenches's concentration in the diet. After 54 days of treatment they were perfused. The cerebellum was sectioned longitudinally and processed for HE, lectin histochemistry (LHC) and immunohistochemistry (IHC) for astrogliosis, microgliosis and demonstration of spheroids. Poisoned guinea pigs showed vacuolation in large neurons like Purkinje cells and cells from deep nuclei. Axonal spheroids were also observed. In LHC, strongly stained neurons with Lens culinary and succinyl-Triticum vulgaris were observed. IHC showed astrogliosis and microgliosis in the molecular layer and white matter, respectively. The results 2 suggest neuronal injury in cerebellum due to the lysosomal storage of high-mannose oligosaccharides, which could affect its functionality. [ABSTRACT FROM AUTHOR]

The cerebral babesiosis induces neurological signs and is an important cause of death in cattle. This work describes an outbreak of natural infection by Babesia bovis in cattle in the Western Frontier of Rio Grande do Sul State, Brazil. A flock with 159 cattle, 13 animals showed neurological clinical signs and died. Three of these animals were necropsied and showed pale mucous membranes, dark-red kidneys, hemoglobinuria, splenomegaly and brain with pink-cherry discoloring. Histologically, may be seen blood congestion and perivascular edema in the nervous system, in addition to large sequestration of erythrocytes in capillaries of de gray matter, caused by organisms with morphology compatible with B. bovis. [ABSTRACT FROM AUTHOR]

Samples of the central nervous system of pigs from two municipalities Veranopolis / RS and Vidal Ramos / SC were received in the laboratory animal pathology CAV / UDESC. According to history, the animals were created so semiextensiva in regions with records of bovine rabies. Reported clinical signs were inappetence, anorexia, paralysis in the hind limbs, lateral recumbency and paddling. The samples were processed for histopathology and immunohistochemistry (IHC) for rabies. Microscopically, there was marked perivascular mononuclear infiltrate, perivascular infiltration of eosinophils and mild multifocal gliosis. The Immunohistochemistry demonstrated marking rabies antigen in the soma and axons of neurons. [ABSTRACT FROM AUTHOR]

This report describes an uncommon case of osteosarcoma in a bull. The laboratory, radiographic and clinicopathological findings are described. Necropsy, gross pathology and histological findings confirmed the mass as a mandibular chondroblastic osteosarcoma. [ABSTRACT FROM AUTHOR]

Twenty five samples of hoof laminar tissue of horses were evaluated histopalogically. The animals were divided in four groups: Control group (Gc), with seven healthy horses; Experimental enterotomy group (Ge), with five horses submitted to jejunal enterotomy; Experimental obstruction group (Go), with eight horses submitted to jejunal obstruction; natural colic group (Gn), with five horses that died after natural colic disease. The horses belonging to groups Go and Gn showed the most severe changes. Histopathologic evaluation of hoof laminar tissue is easy to perform and changes in this tissue are associated to laminitis development, which occur after diseases with systemic involvement. We suggest that routine evaluation of this tissue in horses that died of colic can contribute for estimate organic impairment presented before death. [ABSTRACT FROM AUTHOR]

Tissue fragments for histopathological analysis from 12 cows that were submitted to emergency slaughter under federal inspection, in a slaughterhouse in the region of Araguaína-TO, between january and june 2013, were sent to the Laboratório de Patologia Veterinária da Universidade Federal do Tocantins. The most significant changes were fine vacuolization of hepatocytes by reducing glycogen (83.3%), pulmonary congestion (75%), pulmonary edema (16.66%), pneumonia (16.66%), renal congestion (58, 33%) and granular cylinders (25%). The stress, duration of transport, water and food restriction cause physiological changes to the animals, which result in recommendation for emergency 1 slaughter and condemnation or conditional use of carcass. Tissue lesions founded reinforce that the guideline based on RIISPOA is correct. [ABSTRACT FROM AUTHOR]

In order to determine the frequency of swine enteric disorders diagnosed from 2010 to 2013 at the Animal Pathology Laboratory of UFMG the electronic data base was evaluated. During the studied period, 306 samples were received, and 87 (28.4%) were cases of enteric disorders. Examinations of Poly-Acrilaminade Gel Electrophoresis (PAGE), Polymerase Chain Reaction (PCR), parasitological, bacterial isolation and histopathology were performed. The frequency of detected enteropathogens was the following: Brachyspira sp (21.3%), Rotavirus (17.0%), E. coli (13.8%), Isospora suis (12.8%), Lawsonia intracellularis (10.6%) and Clostridium sp (7.4%). The highest detection rate of Brachyspira sp was probably related to recent outbreaks of swine dysentery that have been detected in Brazil. [ABSTRACT FROM AUTHOR]

This paper aims to report the occurrence of a case of endocarditis associated with reticulum traumatic pericarditis in dairy cattle. The animal had fever, lateral decubitus and opisthotonos. It found little whitish nodules with caseous content in various organs, a friable yellowish mass adhered to the wall heart and fibrinous pericarditis caused by a wire. In the histopathology, the friable mass consisted of a aggregate of bacterial colonies, fibroplasia and monocytic infiltration. It was concluded that reticulum traumatic pericarditis was the responsible for bacteremia leading to endocarditis and later dissemination from septic emboli. [ABSTRACT FROM AUTHOR]

The aim of this study was to analyze the frequency of occurrence of liver diseases, through the observation of microscopic lesions in clinical cases of cattle of different breeds, gender and ages, in the province of Santa Fe, Argentina, in the period between February 2011 and December 2012. 321 samples were analyzed, and in 201 (62.62%) the histopathological lesions suggested the diagnosis of various bacterial, viral, parasitic, toxic and metabolic diseases, highlighting the importance of the collection and submission of samples for microscopic analysis. The most common liver diseases were observed in calves until 1 year, with 50% of them in the first 15 days of life, age of high susceptibility to pathogens. [ABSTRACT FROM AUTHOR]

A mule of approximately 12 years old was admitted to the Hospital Veterinário Universitário da Universidade Federal do Tocantins, presenting acute signs of bilateral blindness, dysphagia, incoordination, prostration (sternal recumbence), depression and apathy. Following clinical evaluation, the animal was euthanized. At necropsy, an ovoid nodule, firm and brownish in coloration, with approximately 1.0 cm x 0.5 cm was noticed in the right lateral ventricle. Histopathology of the nodule revealed dense cellularity, with the majority of the cells arranged in nests, and eventually in cord shape. Perivascular deposition of eosinophilic fibrillar substance was also observed alongside with the cells, as well as a small number of scattered lymphocytes. Neoplastic cells presented with a rounded and moderately hyperchromatic nuclei, and punctuate chromatin. A prominent nucleoli and indistinct cytoplasm were also noticed. Based on these observations, the animal was diagnosed with an ependymoma, a tumor of rare occurrence that may be observed in a great variety of species, including equines. [ABSTRACT FROM AUTHOR]

Squamous cell carcinoma (SCC) with distant metastases is rarely found in horses. The aim of this paper is to describe an unusual form of CCE in a mare of 17 years, which showed destructive, invasive and metastatic spread. The animal showed abnormal mass of tissue in the vulva, which expanded the perineal and inguinal mammary gland, anorexia, progressive weight loss, episodes of colic and recumbency. Due to the poor prognosis and cost of treatment, the owner consented to euthanasia. At necropsy were observed disseminated tumor masses. Histopathological examination showed CCE Grade II. The immunohistochemical analysis revealed positive staining for AE1/AE3. The expression of PCNA showed high tumor growth fraction. Thus showed the epithelial origin and activity proliferative neoplasm. [ABSTRACT FROM AUTHOR]

In recent decades there has been an increase in the number of diseases in sea turtles. The objective of this report was to describe the histopathological findings in the lungs of these animals. To perform the study was obtained samples of 150 turtles necropsied in the coastal regions of Espírito Santo and Rio de Janeiro. Samples harvested lungs were fixed in formalin for 10%, sent for histopathology, to the Setor de Patologia Animal - UENF, processed according to routine histological techniques and stained with hematoxylin-eosin (HE). Of the 150 animals collected, it was observed that 144 were the species Chelonia mydas, two Caretta caretta, two Eretmochelys imbricata and two Lepidochelys olivacea. Findings were granulomatous pneumonia due to parasite eggs in 32 animals, granulomatous mycotic pneumonia in 6 and heterophilic pneumonia in 2 animals. The conclusion of this work that the main alteration found in the respiratory system of C. mydas was granulomatous pneumonia due to parasite eggs. [ABSTRACT FROM AUTHOR]

Research involving the genus Helicobacter has been growing and the infection has been identified in several animal species. The present study aimed to analyze the diagnostic methods of phenicated fuchsin staining in cytological samples, and Warthin-Starry technique in histopathology samples collected from gastric mucosa of domestic cats by endoscopy. Thirteen animals underwent endoscopy to obtain gastric samples. The detection of Helicobacter spp was performed through direct bacterioscopic examination in samples stained with phenicated fuchsin and by histopathology, stained by WS method. The two methods were positive in 100% of samples. It was concluded that these methods have high sensitivity in identifying the genus Helicobacter in gastric mucosa of domestic cats [ABSTRACT FROM AUTHOR]

The aim of this study was to evaluate the effects of phytic acid on intestinal explants exposed to DON and FB1 by histological analysis. Explants of pigs 24 days-old were submitted to the following treatments: control, DON (10μm), FB1 (70μm), IP6 (2,5 mM)+DON (10μm); IP6 (5 mM)+DON (10 μm); IP6(2,5 mM)+FB1 (70 μm); IP6 (5 mM)+FB1 (70 μm), and then processed for histology and stained with HE for determination of lesion score and morphometry. Histologic evaluation showed severe changes in the group treated with DON and moderate when the explants were treated with FB1. Significant reduction in lesional score was observed on explantes exposed to IP6 compared to mycotoxins groups. Gnificant increase in villi height and crypt depth occurred in IP6 groups compared to mycotoxin groups. Addition of phytic acid significantly reduced the explant changes induced by mycotoxins, contributing to the maintenance of the mucosal barrier function and nutrient absorption. [ABSTRACT FROM AUTHOR]

The aim of this study was to evaluate the toxicity of the crude extract of Buchenavia tomentosa by histopathology in Wistar rats. Thirty rats (60 days old) were divided into two groups: Control (n = 15) and experimental (n = 15). The crude extract of the plant was administered by gavage prior to mating and throughout gestation. The dose of the crude extract was corresponding to that is consumed fresh fruit were the only source of power, to simulate the natural ingestion. The control group received only vehicle. At the end of the experiment the animals were euthanized and necropsied to collect and weigh the following organs: heart, lung, thymus, spleen, liver, kidneys and brain. No changes were observed in organ weights and histopathology. It is concluded that the extract of B. tomentosa does not produce deleterious effects on the organs structure in Wistar rats. [ABSTRACT FROM AUTHOR]

bovine Coccidiosis is a parasitic disease common in young animals, responsible for gastrointestinal disorders and death. This paper describes six outbreaks of coccidiosis in beef calves, occurring in the state of Santa Catarina. The clinical picture was characterized by weakness, lethargy, anorexia, dehydration, diarrhea with mucus and blood. Six calves were necropsied and samples of intestine were submitted in 10% formalin for histological examination. How microscopic changes were observed, greenish watery contents in the large intestine mucosa and red coloring. Cecum was yellowish-white spots in the mucosa, ranging from 0.5 to 1 mm in diameter. The histological lesions were observed, evolving forms of Eimeria sp. in the cytoplasm of cells and light intestine crypts. In smear feces and intestinal mucosa was observed lots of oocysts of Eimeria sp. [ABSTRACT FROM AUTHOR]

This study describes an outbreak of hemorrhagic diarrhea mucus in pig farms in Brazil in 2012 and 2013. Fresh and/or formalin fixed cecum and colon samples were submitted to the Department of Veterinary Pathology, UFMG for diagnostic. Samples were, processed for bacterial isolation, PCR, histology and fluorescent in situ hybridization (FISH) using specific probes. Lesions varied from moderate multifocal colitis with goblet cell hyperplasia to severe diffuse fibrinecrotic hemorrhagic colitis. Samples subjected to bacterial isolation were positive for B. hyodysenteriae. There also positive by FISH. Based on clinical and laboratory diagnosis Swine Dysentery caused by B. hyodysenteriae was confirmed. [ABSTRACT FROM AUTHOR]

The neoplasia is caused by a genetic derivative of a variety of factors that may involve many domestic animals. Hepatocellular carcinoma is configured as a malignant liver tumor which, although it has been observed in several species including dogs, cats, cattle, horses, sheep and pigs, is rare in birds. Describes the macroscopic and histological hepatocellular carcinoma in a domestic chicken comparing them with the descriptions of this tumor in the literature. [ABSTRACT FROM AUTHOR]

Sporadic bovine leukosis is a neoplastic disease affect young cattle, and there are three forms: juvenile, thymic and cutaneos form. In March 2013, necropsy was done a mixed heifer with six months old with bloat and limited mobility there are 15 days. Macroscopically observed pale mucous, tumor masses with yellowish-white color and friable in mediastinal, submandibular and mesenteric lymph nodes and spinal canal. Microscopically observed atypical lymphocytes of scant cytoplasm, pleomorphic nucleus and frequent mitoses. The diagnostic was based on macroscopy and microscopy alterations. [ABSTRACT FROM AUTHOR]

A case of equine multinodular pulmonary fibrosis (EMPF) is reported in a thoroughbred mare with clinical signs of severe respiratory distress The diagnosis of EMPF was confirmed by necropsy findings, histopathology and by detection of equine herpesvirus type 5 (EHV-5) DNA by the polymerase chain reaction (PCR). [ABSTRACT FROM AUTHOR]