1. Immune recovery uveitis in a patient with herpes retinitis as a complication of hairy cell leukaemia.
- Author
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Sánchez-Vicente JL, Rueda-Rueda T, Moruno-Rodríguez A, de Las Morenas-Iglesias J, Lechón-Caballero B, and López-Herrero F
- Subjects
- Antineoplastic Agents therapeutic use, Humans, Immune Reconstitution Inflammatory Syndrome diagnosis, Leukemia, Hairy Cell drug therapy, Male, Middle Aged, Pentostatin therapeutic use, Uveitis diagnosis, Visual Acuity, Herpesviridae Infections, Immune Reconstitution Inflammatory Syndrome immunology, Leukemia, Hairy Cell complications, Retinitis virology, Uveitis immunology
- Abstract
A 51 year-old man with hairy cell leukaemia was treated with pentostatin. While receiving the treatment, he was diagnosed with herpes retinitis in his right eye. After the last cycle of pentostatin the patient developed a mild vitritis and cystoid macular oedema. There were no signs of herpes retinitis reactivation. After excluding other possible causes of intraocular inflammation, a diagnosis of immune recovery uveitis was made. The patient was treated with 2-monthly retro-septal injections of triamcinolone, oral corticosteroids, intravitreal dexamethasone implants and, finally, pars plana vitrectomy. An immune recovery uveitis-like response is possible in HIV negative individuals. The immune reconstitution after the treatment of hairy cell leukaemia may have led to intraocular inflammation. Management of immune recovery uveitis is challenging and difficult. Pars plana vitrectomy may be necessary. Ophthalmologists should be alert to the possibility of immune recovery uveitis in HIV negative patients., (Copyright © 2019 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2019
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