This article describes and compares the comprehensive waste management (GIR) and comprehensive water resources management (GIRH) in the northeast region of Uruguay from a perspective of territorial governance and sustainable development. It examines national environmental regulations and their application in the departments of Rivera, Cerro Largo, and Tacuarembó, framed by the Millennium Development Goals (MDGs) and the Sustainable Development Goals (SDGs). The article seeks to identify milestones in the process and considers the participation of non-state actors in the sustainable development of the territory. Two executing units were created in Uruguay based on Law 19,889: the National Directorate of Quality and Environmental Evaluation and the National Directorate of Biodiversity and Ecosystem Services. Additionally, there are other entities such as the National Water Directorate, the Climate Change Unit, and the National Climate Change Response System. In the Northeast region of the country, composed of the departments of Rivera, Cerro Largo, and Tacuarembó, there are challenges in the comprehensive management of waste and water resources due to a lack of economic diversification and low human development indices. In Tacuarembó, projects for waste management have been promoted, such as the Uruguay Classifies program and the Green and Inclusive Curtina project. In Rivera, waste management initiatives have been carried out for over 20 years, such as the Your Battery is Worth It program and the Pilot Plan for Packaging Management. The article presents information on solid waste management and water governance in the departments of Rivera and Cerro Largo in Uruguay. In Rivera, various programs and projects have been implemented to improve the final disposal of waste, including selective collection, recycling, and material reuse. In Cerro Largo, there is a lack of attention from the departmental government in waste management, although the construction of a sanitary landfill and a recycling plant have been proposed. Regarding water governance, the creation of the National Water Directorate and the implementation of the National Water Policy in Uruguay are highlighted. The article presents the creation of the National Council for Water, Environment, and Territory in Uruguay, with the aim of formulating a national water resources management plan. The importance of sustainable, integrated, and participatory water resources management is emphasized, with the participation of the government, users, and civil society. The creation of regional water resources councils and basin and aquifer commissions is mentioned to ensure the representativeness of local actors and address conflicts related to water use. The National Water Plan approved in 2017 and ongoing efforts to improve water quality in the Negro River basin are also mentioned. The importance of inter-institutional coordination and multi-actor participation in water resources management is highlighted. The Northeast region has consolidated governance in water matters, with a multi-level and multi-actor approach. The departments of Rivera and Tacuarembó have a long history of institutional coordination in watershed management. As for waste management, this region has recently incorporated governance into its environmental regulations and agenda. There is a favorable link between the national and subnational levels in terms of environmental policies, and the participation of local actors, including environmental NGOs, has been strengthened. The challenge is to achieve effective coordination among different actors and resolve conflicts in the multi-actor network. [Extracted from the article]