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The "Wells syndrome" is a rare inflammatory dermatosis of unknown pathogenesis, clinical polymorph, both the location and the extent of the lesions. This is a skin disease of inflammatory origin, which usually appears in children and adolescents. Has a polymorphic clinical picture, both the location and the extent of the lesions, and for the correct interpretation of diagnostic histopathological lesions required. This entity should be considered in the differential diagnosis of any atypical presentation of cellulite with peripheral eosinophilia, that does not respond to antibiotics. [ABSTRACT FROM AUTHOR]

Wells' syndrome is a rare eosinophilic dermatitis first described 40 years ago, with a wide clinical spectrum and varied histology according to the stage of the cutaneous lesions, associated with numerous endogenous and exogenous factors, including infectious and gastrointestinal diseases. We present the case of a woman with a 10-day history of edematous, itching and recurrent plaques in limbs with pustules in the right cheek, chest, abdomen and hips. Wells' syndrome was diagnosed and the following findings were documented: flame figures in the histological sections, negative immunofluorescence for immune complexes and complement deposits, peripheral blood eosinophilia, and Helicobacter pylori infection confirmed by endoscopy and gastric biopsy. Possible physiopathological mechanisms of a new association with H. pylori are discussed. It may be a coincidence or a possible etiology that should be further investigated. [ABSTRACT FROM AUTHOR]