1. Sistemik Isotretinoin Tedavisi Alan Hastalarda Gözyaşı ve Oküler Yüzey Değişiklikleri.
- Author
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Çetin, Ebru Nevin, Şanlı, Berna, Bir, Ferda, Yaldızkaya, Filiz, Kaçar, Nida, and Yaylalı, Volkan
- Subjects
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ACNE , *DRY eye syndromes , *EPITHELIAL cells , *EYE , *ISOTRETINOIN , *LONGITUDINAL method , *TEARS (Body fluid) , *FRIEDMAN test (Statistics) , *THERAPEUTICS - Abstract
Purpose: Our aim in this study was to assess the ocular surface and tear film changes in acne vulgaris patients receiving systemic isotretinoin. Material and Method: Twenty-two eyes of 22 patients who received oral isotretinoin (roaccutane®, 0.7 mg/kg/day) for nodular acne vulgaris were enrolled in this prospective study. Tear film break-up time (BUT), Schirmer 1 test scores with anesthesia, ocular surface disease index (OSDI) scores and conjunctival impression cytology scores were recorded before treatment and at 3- and 6-month visits following the beginning of treatment. Results: BUT values decreased and OSDI scores significantly increased at 3 months after treatment (p = 0.007 and p = 0.018, paired samples test). Schirmer scores did not significantly change by isotretinoin treatment. Of 9 eyes with impression cytology specimens, 4 revealed normal conjunctival findings before treatment. At the 3rd month, there was an increase in the scores characterized by decrease of Goblet cells, and at 6 months of treatment, normal conjunctival findings did not exist in any of the patients (p=0.004, Friedman test). Discussion: Systemic isotretinoin treatment can cause alterations in the tear film and cause dry eye symptoms. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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