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Objective: Pneumonia is among the most common infectious causes of death worldwide. Mortality can reach up to 30% in pneumosepsis cases requiring intensive care unit(ICU) admission. In recent years, procalcitonin/albumin ratio(PAR) has emerged as an essential parameter for identifying critical patients. This study aimed to evaluate the role of PAR in predicting pneumosepsis in critical patients admitted to the ICU due to pneumonia. Material and Method: This study was conducted retrospectively on 300 patients requiring ICU admission due to pneumonia between June 01, 2022 and November 15, 2023, at a training and research hospital anesthesia and chest diseases intensive care units. The patients sociodemographic characteristics and vital signs were obtained from the patients physical files, while laboratory results and radiological images were examined through the hospital's internal information management system (HIMS). Results: Three hundred patients were included in the study. The mean age of the patients was 64.97±16.64. 107 (35.6%) of the patients included in the study were female. 217 (72.4%) of the patients included in the study had pneumosepsis. 21(11%) of the patients included in the study died within 30 days of follow-up. PAR was 0.31±0.82 in patients with pneumonia and 1.56±4.96 in patients with pneumosepsis. There was a significant difference between the groups(p< 0.001). The cutoff value for PAR was determined as 0.042 with 73.3%sensitivity and 50.6%specificity. PAR was defined as a predictive factor of pneumosepsis (AUC 0.631 95%CI, 0.532-0.701; p< 0.001). Conclusion: The procalcitonin to albumin ratio can be used to predict sepsis related mortality in intensive care unit patients with pneumonia admission. [ABSTRACT FROM AUTHOR]

Amaç: C-reaktif protein/albümin oranı (CAO) yakın zamanda yeni bir inflamatuar biyobelirteç olarak tanımlanmış ve inflamasyonun belirlenmesinde birçok hastalıkta potansiyel rolü ortaya konulmuştur. Bu çalışma, aksiyel spondiloartritte (axSpA) hastalık aktivitesinin belirlenmesinde CAO’nun rolünü araştırmayı amaçlamaktadır. Gereç ve Yöntem: Bu çalışma retrospektif vaka-kontrol çalışmasıdır. Toplam 128 hasta ve 111 yaş-cinsiyet uyumlu sağlıklı kontrol çalışmaya dahil edilmiştir. Serum albumin, C-reaktif protein (CRP), eritrosit sedimantasyon hızı (ESH) kaydedildi. CAO, serum CRP/Albumin şeklinde hesaplanmıştır. Hastalık aktivitesini belirlemek için Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BASDAI) ve Ankilozan Spondilit Hastalık Aktivite Skoru-CRP (ASDAS-CRP) skorları kullanıldı. Hastalar ASDAS-CRP skoruna göre iki alt gruba ayrıldı: ≥1,3 aktif hastalık,

Objective: The C-reactive protein/albumin ratio (CAR) has recently emerged as a novel inflammatory biomarker, indicating its potential role in determining inflammation in various disorders. This study aims to investigate the role of CAO in determining disease activity in axial spondyloarthritis (axSpA). Material and Method: This study is a retrospective case-control study. A total of 128 patients with axSpA and 111 age-gender-matched healthy controls were included in the study. Serum albumin, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were recorded. CAR was calculated as serum CRP/Albumin. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score-CRP (ASDAS-CRP) scores were used to determine disease activity. Patients were divided into two subgroups based on the BASDAI score: =4 was considered active disease, and <4 was considered an inactive disease. Additionally, axSpA patients were also subdivided into radiographic and non-radiographic disease groups. Results: CAR was significantly higher in axSpA patients compared to healthy controls (1.42 (0.91-4.49) and 0.46 (0.25-0.95), p<0.001, respectively). Similarly, CAO was found to be significantly higher in patients with active disease compared to those with inactive disease (4.61 (2.04-6.87) and 0.977 (0.75-1.52), p<0.001, respectively). CAR showed a significant correlation with CRP, ESR, BASDAI, and ASDAS-CRP (r=0.996, p<0.001; r=0.471, p<0.001; r=0.779, p<0.001, r=0.842, p<0.001, respectively). The area under the curve (AUC) for distinguishing active from inactive disease using CAR was 0.795 (95% confidence interval (CI) 0.714-0.861; p<0.001). Conclusion: CAR correlates highly with disease activity in axSpA. It can potentially be a useful biomarker for determining and monitoring inflammation in axSpA. [ABSTRACT FROM AUTHOR]

Copyright of MN Cardiology / MN Kardiyoloji is the property of Medical Network and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim:We investigated the relationship between serum albumin level and the prognostic nutritional index (PNI) with tumor histopathology, especially in localized clear cell renal cell carcinoma (ccRCC) patients. Moreover, the prognostic value of these markers in predicting metastatic progression was assessed.Methods:A total of 120 RCC patients who underwent nephrectomy between January 2016 and January 2021 were evaluated. The inclusion criteria were having a ccRCC subtype. Patients who had metastatic disease and N+ status at the time of diagnosis were not included. Serum albumin level and PNI were compared between several tumor histopathology parameters and between patients who exhibited and did not exhibit metastatic progression.Results:The serum albumin level and PNI exhibited significant differences in patients with pathologically higher tumor grade and metastatic progression during follow-up compared to patients with lower tumor grade and non-metastatic follow-up. Serum albumin levels and PNI were correlated with tumor grade and metastasis. In the univariate model, serum albumin and PNI were associated with metastasis [hazard ratio (HR): 0.29; 95% confidence interval (CI): 0.09-0.97; p=0.04; and HR: 0.88; 95% CI: 0.78-0.99; p=0.04].Conclusion:Lower serum albumin and PNI are associated with higher tumor grades in patients with localized ccRCC. Moreover, they were prognostic role in metastatic progression during the follow-up of the patients after nephrectomy.

Aim The Glasgow Prognostic Score (GPS) is a scoring system obtained by using inflammatory (C-reactive protein) and nutritional (albumin) parameters together, and it has been shown to have prognostic value in various cardiac pathologies in previous studies. In this study, we aimed to investigate the usability of the Glasgow Prognostic Score (GPS) in predicting 1-year mortality in patients who underwent transcatheter aortic valve implantation (TAVI). Method Patients who underwent TAVI with the diagnosis of severe, symptomatic aortic stenosis in our hospital between 2013 and 2017 were included in this single center study retrospectively. Demographic, clinical and laboratory data were obtained by reviewing patient files. GPS value was calculated by using C-reactive protein and albumin values which was obtained on admission to. Two groups were formed as survivors and non-survivors according to 1-year mortality data. Results A total of 170 patients were included in this retrospective study and 59 patients constituted the non-survivors group. History of chronic obstructive pulmonary disease and cerebrovascular disease were higher in non-survivors’ group. High STS-TAVR, Euro SCORE II and GPS levels were also higher in non-survivors group. High GPS value calculated with pre-procedural data was determined as a predictor of 1-year mortality. Conclusion The Glasgow Prognostic Score allows the evaluation of inflammation and nutritional status together, is a practical method that can be obtained from routine laboratory parameters. It can be used as a predictor of mortality in patients undergoing TAVI. It can guide clinicians in taking preventive measures to reduce mortality before the procedure.

Objective: Albumin is the main carrier molecule that makes up 55-60% of the proteins in the blood. In clinical applications, its levels are measured in serum, urine and body fluids. In the case of urinary albumin loss and/or decreased liver production, albumin levels in the blood decrease, but the reasons for increasing serum albumin levels are very limited. We planned this study as a method comparison study due to the feedback that albumin measurements made in our hospital's laboratory were relatively high. Methods: Fourty patients were included in the study, albumin levels in serum samples were measured with bromcresol green and bromcresol purple methods on the same day, and the data were evaluated with SPSS 26.0 package program. Measurements were made on the Alinity c-series (Abbott Laboratories, Chicago, IL, USA) autoanalyzer using their kit. Average Bias was 0.535 and % Bias was 14.22 between the two methods. Results: While the difference between the means of the two methods was statistically significant (p<0.001), there was a positive, strong (r=0.959) and statistically significant (p<0.001) correlation between the methods, and the p<0.05 level was considered statistically significant. Conclusion: It was evaluated that the measurement results for both methods were within the limits of medically permissible error, but further study was needed to compare both methods separately with the reference method. [ABSTRACT FROM AUTHOR]

Purpose: The aim of our study was to determine whether C-reactive protein/albumin is an age-related marker in Covid-19 pneumonia. Materials and Methods: We performed a retrospective research on 296 patients (166 male/130 female) with Covid-19 pneumonia. The participants were divided into two groups as

Objective: Systemic inflammation plays a significant role in the etiopathogenesis of vitiligo. The serum C-reactive protein (CRP)/albumin ratio (CAR) has been reported as an important prognostic marker in many inflammatory diseases. To determine the CAR value in patients with vitiligo and healthy controls and investigate the relationship of this parameter with vitiligo severity and activity. Material and Methods: Seventy-eight patients diagnosed with vitiligo in our hospital and 78 age- and gender-matched healthy controls were retrospectively included in the study. Disease severity was assessed using the Vitiligo Area and Severity Index. The Vitiligo Disease Activity Score (VIDA) was used to determine disease activity. The CAR value was calculated by dividing the serum CRP values by the serum albumin values for the patient and control groups. Results: Of the 78 patients with vitiligo in these study, 30 (38%) were male and 48 (62%) were female, and their mean age was 33±8.9 years. In the healthy controls, 32 (41%) participants were male and 46 (59%) were female, with a mean age of 35.8±9.7 years (p>0.05). The serum CRP level was mean 0.82±0.44 mg/dL in the vitiligo group and 0.31±0.17 mg/dL in the controls (p=0.001). The mean CAR values of the vitiligo was 0.21±0.12 and healthy controls was 0.07±0.04 (p=0.001). A positive correlation was observed between the VIDA score and CAR (r=0.54; p<0.01) and CRP (r=0.47; p<0.01). The CAR cut-off value was calculated as 0.2 with 78% sensitivity and 80% specificity. Conclusion: The CAR value may be indicative of systemic inflammation and disease activity in vitiligo. [ABSTRACT FROM AUTHOR]

Copyright of International Journal of Life Sciences & Biotechnology (2651-4621) is the property of International Society of Academicians and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Purpose: This study aims to assess the diagnostic utility of C-reactive protein (CRP) to albumin ratio (CAR) for predicting elevated D-dimer levels in COVID-19. Materials and Methods: This retrospective cohort study collected data from 145 hospitalized patients with confirmed COVID-19 in a university hospital. Patients were divided into two groups based on their D-dimer levels, as elevated D‐dimer levels and normal D-dimer levels. Demographic data, comorbidities, clinical symptoms, CAR, and laboratory results were obtained from the patients’ medical records and compared between the groups. Results: The mean age of patients was 52.9±17.9 years, and 76 of them were male. The median of CAR was significantly higher in those with higher D-dimer (134.1 vs. 20.7). CRP, procalcitonin, leukocyte, neutrophil, lactate dehydrogenase, ferritin, and fibrinogen were higher in patients with elevated D-dimer levels. There was a highly significant positive correlation between CAR and D-Dimer. Logistic regression analysis revealed that CAR was a significant determinant for elevated D‐dimer levels . The area under the ROC curve (AUC) was 0.741 for CAR. The verified cut-off value of CAR for predicting elevated D‐dimer levels in patients with COVID-19 was 81.8, with a sensitivity of 58% and a specificity of 70%. Conclusion: Our study revealed that CAR was significantly correlated with D-dimer and can be used to predict elevated D‐dimer levels in patients with COVID-19.

Aim:Kawasaki disease (KD) is difficult to diagnose in infants, since the disease course is subtle. We aimed to identify whether infants with KD demonstrate significant alterations in laboratory parameters that can be used to distinguish them from other febrile infants.Materials and Methods:In this retrospective case-control study, infants diagnosed with KD between January 2010 and December 2019 were evaluated and compared to a cohort of febrile infants admitted with prolonged fever during the same period. Demographic, clinical, and laboratory features were recorded and compared between these two groups.Results:A total of 42 infants (27 male) with KD (32 incomplete KD) and 84 age-matched febrile infants (57 male) were evaluated. Coronary artery involvement was identified in 20 (47.6%) infants of whom 5 (25%) had coronary aneurysms. All infants with KD were treated with IVIG and high dose acetylsalicylic acid, and 38 (90.5%) responded to treatment. The duration of fever and hospitalization were longer in infants with KD compared to the controls (p

AIM The course of infection due to SARS-CoV-2 is manifested by viral replication in the upper respiratory tract with or without lung involvement and extrapulmonary systemic hyperinflammation syndrome. Because it has a wide clinical spectrum ranging from asymptomatic cases to multiorgan failure, early identification of prognostic biomarkers is crucial to distinguish patients at risk of developing more serious disease. Our aim is to investigate the relationship between the biomarker CAR, which has both prognostic and diagnostic importance, and Covid 19 infection. MATERİALS AND METHODS Between 1 June 2021 and 1 September 2021, 215 patients who were followed up in the pandemic service and intensive care unit for Covid 19 pneumonia were retrospectively analyzed. The demographic and routine laboratory data of the patients and the parameters accepted as new inflammatory biomarkers such as NLR, PLR, LMR and CAR were compared between the service-intensive care unit and exitus-discharged groups. RESULTS A total of 205 patients with a diagnosis of Covid 19 pneumonia, 113 (55.1%) male and 92 (44.9%) female, were included in the study. When CAR, known as a new inflammatory biomarker, was compared between both groups, it was found to be statistically significantly higher in patients hospitalized in the intensive care unit (p

Aim:Although there are few studies on the predictive value of C-reactive protein-to-albumin ratio (CAR) in coronavirus disease-2019 (COVID-19) patients, to the best of our knowledge, there are no studies specifically conducted in COVID-19 patients with cardiovascular disease (CVD). This study assessed the use of baseline CAR levels to predict death in hospitalized COVID-19 patients with CVD.Methods:This study was designed as a single-center cross-sectional study. Patients diagnosed with COVID-19 who were admitted to the University of Health Sciences Turkey, Bagcilar Training and Research Hospital between April 16 and May 20, 2020 were analyzed retrospectively. The patients were divided into 2 groups: those who died and those who survived, considering the follow-up period. The CAR values of the study population, as well as patients with CVD, were calculated, and the association of CAR with in-hospital mortality was evaluated.Results:The in-hospital mortality rate was 11.1% (49/442 pts) in all populations. Deceased patients had significantly more frequent CVD (p

Objective:The prognostic role of the initial lactate/albumin ratio (LAR) in critically ill patients with coronavirus disease-2019 (COVID-19) remains unknown. This study aimed to evaluate the prognostic value of the initial LAR in predicting 30-day mortality in critically ill patients with COVID-19 and compare the initial level of serum lactate and albumin for mortality prediction.Materials and Methods:A single-center and observational clinical study between April 2020 and December 2020 were retrospectively performed. Clinical and laboratory variables of patients evaluated in this study were collected within the first 24 hours following the intensive care unit (ICU) admission.Results:A total of 282 critically ill patients with COVID-19 were included in the study. The mean age of the patients was 66.34±12.08 years, wherein 179 (63.5%) were male. Patients who died within 30 days had higher lactate (p0.60.Conclusion:LAR is a useful prognostic factor for risk stratification of critically ill patients with COVID-19.

Copyright of Hamidiye Medical Journal is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Amaç: Bu çalışmada obsesif kompulsif bozukluk (OKB) hastalarında ürik asit, albümin, total bilirubin ve gamma glutamil transferaz (GGT) gibi serumda ölçülebilen oksidatif stres ile ilişkili basit laboratuvar parametrelerini sağlıklı kontroller ile karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Gaziantep Üniversitesi Tıp Fakültesi Hastanesi Psikiyatri polikliniğinde DSM-5 kriterlerine göre OKB tanısı ile tedavi edilen hastalar alınmıştır. OKB tanısı konulan 117 hasta ve hasta grubu ile demografik veriler ile eşleşebilecek 80 kişi sağlıklı kontrol grubu olarak alındı. Hasta ve kontrol grubu serum ürik asit, albümin, total bilirubin ve GGT açısından karşılaştırıldı. Hastaların klinik özellikleri Yale Brown Obsesyon Kompulsiyon Ölçeği (Y-BOCS) ve Klinik Global İzlenim Şiddet Ölçeği (KGI-S) ile değerlendirildi. Bulgular: Hasta grubu yaş ortalaması 36.68±13.06 iken kontrol grubunun 35.54±8.82’di. Total bilirubin düzeyine bakıldığında hasta grubunda 0.69±2.19 mg/dL ve kontrol grubunda 0.63±0.47 mg/dL olmakla birlikte gruplar arasında anlamlı farklılık vardı. GGT düzeyi hasta grubunda 22.85±15.80 U/L ve kontrol grubunda ise 19.29±11.52 U/L olmakla birlikte gruplar arasında anlamlı fark yoktu. Sonuç: Hastalar bilirubin dışında doğal antioksidan açısından kontrollerden farklı değildi. Çalışmamızdaki bulgular OKB ile ürik asit, albümin ve GGT arasında nedensel bir ilişki olduğunu desteklememektedir.

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Objektives: Many parameters such as age, length of hospital stay, need and duration of mechanical ventilation, concomitant comorbidities, infection, and laboratory parameters have an effect on intensive care patient mortality. In our research, we purposed to investigate which of these parameters have an effect on intensive care patient mortality. Methods: Our study, which was planned retrospectively, included 295 patients over the age of 18 who were hospitalized in the intensive care unit of our hospital between January 2018 and December 2019. They were divied up into two groups as discharged and ex-patients. The relationship between the parameters and mortality was compared between the groups. Results: The mean age of the patients, of whom 53.6% (n: 158) was male, was 76 years. The presence of neurological diseases, advanced age, and high Apache II score cause a significant increase in the mortality rate. Mortality was higher in patients considered to be intubated. High lactate, high RDW level, and low albumin levels were associated with increased mortality. It was determined that sodium and MPV values did not have a significant relationship with mortality. The mortality rate was found to be lower in patients who were hospitalized for less than 15 days. Conclusion: RDW, Albumin, and lactate values were found to affect the prognosis of the patients hospitalized in the intensive care unit. Following these values; will be beneficial in terms of starting treatment in the early period. [ABSTRACT FROM AUTHOR]

Objective Recently, the CRP / albumin ratio, a combination of blood markers for systemic inflammation and nutritional status, has been found to be an independent prognostic marker in patients with infection, malignancy, and other diseases. In our study, we aimed to investigate the effectiveness of the CRP-albumin ratio at admission in predicting the ileus type and prognosis in hospitalized patients. Material and Methods Patients over the age of 18 who applied to the emergency department and were later diagnosed with ileus were included in the study. Demographic characteristics, laboratory parameters, surgical intervention, length of stay and in-hospital mortality of the patients were determined. It is divided into paralytic or mechanical according to its etiology. The CRP/albumin ratio (CAR) was calculated, and the effect of CAR in predicting the ileus type and mortality was investigated. Results A total of 116 patients were investigated. 72 (62.1%) of the patients were male and the mean age was 65.12 years. Mechanical ileus was detected in 81 (69.8%) of them. According to ileus types, 66.7% of patients with mechanical ileus received medical treatment, while 97.1% of patients with paralytic ileus received medical treatment. Medical treatment was more common in patients with paralytic ileus (p<0.001). The CAR value was found to be 3.72 in patients with mechanical ileus and 5.77 in patients with paralytic ileus (p=0.046). In the logistic regression analysis examining CAR, WBC, length of stay, neutrophil and lymphocyte count, and CRP value in all ileus patients, it was revealed that no parameter was an independent indicator for mortality. Conclusion The CAR value can be useful in determining ileus type. While it may be useful in predicting mortality in ileus patients, it is not an independent indicator. [ABSTRACT FROM AUTHOR]

Copyright of Ege Journal of Medicine is the property of Ege University, Faculty of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Cancer that progressively increasing prevalence and mortality of, causes malnutrition due to metabolic disorders and treatment side effects. Percutaneous endoscopic gastrostomy (PEG) and gastrojejunostomy are common applied nutritional support methods. In this our study, we aimed to identify that diagnoses, stages, operation-related laboratory parameters of patients, and to emphasise significance of planning appropriate nutritional support in this patient group as soon as possible. Methods: Descriptive analyses were used for the sociodemographic data of 65 cases who underwent surgical nutritional support in Gaziosmanpaşa University Research and Application Hospital between 01.03.2008 and 01.08.2019. Differences between groups were analysed using the independent sample T Test, and the data of continuous variables were given as mean ± standard deviation. p lt;0.05 accepted statistically meaningful. Findings: Stomach and head- neck cancers were the most frequent diagnoses, respectively, among patients who supported via surgical feeding methods. While surgical procedures were performed in stage 3-4 in the gastric cancer patient group, procedures were applied in stage 1-2 in the patient group with head and neck cancer. The relationship between low albumin levels (3,3±0,65) and late mortality was statistically meaningful. (p lt;0,001) Conclusions: Nutritional support methods are frequently performed in the growing cancer patient population. Considering the predictable risk factors in nutritional deficiency and treating in the early period contribute positively to survival.

Copyright of Osmangazi Journal of Medicine / Osmangazi Tip Dergisi is the property of Eskisehir Osmangazi University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aim:To evaluate the effects of residual renal function (RRF) on anemia treatment, phosphorus control and nutritional parameters in peritoneal dialysis (PD) patients.Methods:PD patients were retrospectively analyzed. Besides anthropometric measurements, biochemical measurements, such as residual glomerular filtration rate (rGFR), normalized protein catabolic rate (nPCR), hemoglobin (Hb), serum albumin, calcium, phosphorus, ferritin, parathormone and C-reactive protein levels were recorded.Results:One hundred and fifteen patients (52 females, 63 males; mean age: 56.0±13.2 years 20-83 years) receiving PD treatment were analyzed. The patients were divided into two groups according to presence or absence of RRF (n=75 and n=40, respectively). Patients with RRF had higher body weight (80±14 kg vs 68±13 kg; p

Objective: The prognostic nutritional index (PNI), based on serum albumin and lymphocyte concentration, is an inflammation-based nutritional score that has been shown to be a prognostic determinant in several populations. The aim of this study was to investigate the impact of PNI on mortality in patients with infective endocarditis (IE). Methods: A total of 131 patients with IE were enrolled in this retrospective study. The patients were divided into 2 groups based on in-hospital mortality. The PNI value of the patients was evaluated, as well as baseline clinical and demographical variables. Results: Among the study group, 29 patients died in-hospital during the median follow-up of 37 days. The PNI was found to be lower in cases of mortality (35.90+-6.96; 31.09+-5.88; p=0.001). ROC curve analysis also demonstrated that the PNI had a good predictive value for in-hospital mortality with a cut-off value of 35.6 (Area under the curve: 0.691; 95% confidence interval [CI]: 0.589–0.794; p=0.002). In multivariate logistic regression analysis, advanced age (Odds ratio [OR]: 1.078; 95% CI: 1.017–1.143; p=0.012), PNI (OR: 0.911; 95% CI: 0.835–0.993; p=0.034), and leaflet perforation (OR: 5.557; 95% CI: 1.357–22.765; p=0.017) were found to be independent predictors of mortality. Kaplan-Meier survival analysis revealed that long-term survival was found to be significantly decreased in patients with a lower PNI (Log rank: p=0.008). Conclusion: The PNI result was associated with an increased in-hospital mortality rate in patients with IE. The PNI value, advanced age, and cardiac valve perforation as a complication of IE were found to be independent predictors of mortality.

Objective: The aim of this study is to investigate the changes in albumin levels in patients with acute pulmonary embolism (PE) and to evaluate the diagnostic value in clinical forms of PE. Material and Method: One hundred ten patients who applied to Chest Diseases Clinic and were diagnosed with PE were included in the study retrospectively. PE patients were divided into three groups as 28 massive, 33 submassive and 49 nonmassive, according to the clinical form. Differences in serum albumin, CRP and D-dimer results and other markers were analyzed among the three groups. Results: Serum albumin levels were found to be statistically lower in the massive group compared to the submassive and nonmassive groups (p =0.003 and p =0.001, respectively). CRP levels were statistically higher in the massive group than the non-massive group p =0.027. There was a negative correlation between right ventricular diameter (RVD) and serum albumin levels (r =-0.26, p =0.005). When albumin cut-off value was taken as ≤3.35 to predict massive embolism by ROC analysis, albumin sensitivity was found to be 79% and specificity to be 70% (AUC = 0.75, 95% CI = 0.64-0.85, p =0.001). Conclusion: Albumin is known as a negative acute phase reactant and its lower levels in massive PE may reflect an increased inflammatory state. Also, low albumin levels can be an indicator of the severity of acute pulmonary embolism. [ABSTRACT FROM AUTHOR]

Background: Peritonsillar abscess is a serious infectious disease of the tonsil tissue. Treatment usually requires both medical and surgical approaches to relieve symptoms. Recently, some tests such as C-reactive protein (CRP) and albumin in addition to clinical follow-up are thought to be additional inflammatory monitoring markers. Aim: The aim of this study is to investigate whether the CRP/albumin ratio can be used to predict conversion to peritonsillar abscess in patients with acute tonsillitis. Patients and methods: This study was conducted by retrospectively evauating the CRP / albumin ratios of 138 patients with acute tonsillitis and 106 patients with peritonsillar abcess who were admitted to our clinic between January 2003 and June 2020. Leukocyte count, neutrophil count, lymphocyte count, C – reactive protein, albumin and neutrophil – lymphocyte ratio values were simultaneously analyzed and compared between groups. Results: CRP / albumin ratio levels were significantly higher in the peritonsillar abscess group than in the acute tonsillitis group (p < 0.05). There was no significant difference between peritonsillar abscess and acute tonsillitis group in neutrophil-lymphocyte ratio levels (p > 0.05). While the rate of albumin was found to be significantly lower in the peritonsillar abscess group, the lymphocyte count was found to be significantly higher. There was no significant difference between the groups in terms of white blood cell count, neutrophil count, C-reactive protein values (p > 0.05). Conclusion: The CRP / albumin ratio is thought to be an easy-to-measure, reproducible, non-invasive prognostic score that can be used to predict peritonsillar abscess formation in patients with acute tonsillitis. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this stıudy was to examine easy laboratory parameters associated with oxidative stress that can be measured in serum such as uric acid, albumin, total biluribine and gamma glutamyl transferase (GGT) in patients with obsessive compulsive disorder (OCD) by comparing them with healthy controls. Materials and Methods: 117 Patients who were diagnosed as OCD according to DSM-5 criteria and 80 healthy controls were included in the study. Patient and control groups were compared in terms of serum uric acid, albumin, total biluribine and GGT. Yale Brown Obsession Compulsion Scale and Clinical Global Impression Scale were used to assess clinical characteristics of the patients. Results: The mean age of the patients was 36.68±13.06 years, while it was 35.54±8.82 in control group. Total biluribin levels was higher in patients (0.69±2.19 mg/dL) than controls (0.63±0.47 mg/dL). Although the GGT level was 22.85 ± 15.80 U / L in the patient group and 19.29 ± 11.52 U / L in the control group, there was no significant difference between the groups. Conclusion: Patients did not differ from controls in terms of natural antioxidant, except bilirubin. The results do not support a causal relationship between OCD and uric acid, albumine and GGT. Purpose: The aim of this stıudy was to examine easy laboratory parameters associated with oxidative stress that can be measured in serum such as uric acid, albumin, total biluribine and gamma glutamyl transferase (GGT) in patients with obsessive compulsive disorder (OCD) by comparing them with healthy controls. Materials and Methods: 117 Patients who were diagnosed as OCD according to DSM-5 criteria and 80 healthy controls were included in the study. Patient and control groups were compared in terms of serum uric acid, albumin, total biluribine and GGT. Yale Brown Obsession Compulsion Scale and Clinical Global Impression Scale were used to assess clinical characteristics of the patients. Results: The mean age of the patients was 36.68±13.06 years, while it was 35.54±8.82 in control group. Total biluribin levels was higher in patients (0.69±2.19 mg/dL) than controls (0.63±0.47 mg/dL). Although the GGT level was 22.85 ± 15.80 U / L in the patient group and 19.29 ± 11.52 U / L in the control group, there was no significant difference between the groups. Conclusion: Patients did not differ from controls in terms of natural antioxidant, except bilirubin. The results do not support a causal relationship between OCD and uric acid, albumine and GGT. [ABSTRACT FROM AUTHOR]

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Aim: To evaluate the effects of residual renal function (RRF) on anemia treatment, phosphorus control and nutritional parameters in peritoneal dialysis (PD) patients. Methods: PD patients were retrospectively analyzed. Besides anthropometric measurements, biochemical measurements, such as residual glomerular filtration rate (rGFR), normalized protein catabolic rate (nPCR), hemoglobin (Hb), serum albumin, calcium, phosphorus, ferritin, parathormone and C-reactive protein levels were recorded. Results: One hundred and fifteen patients (52 females, 63 males; mean age: 56.0±13.2 years 20-83 years) receiving PD treatment were analyzed. The patients were divided into two groups according to presence or absence of RRF (n=75 and n=40, respectively). Patients with RRF had higher body weight (80±14 kg vs 68±13 kg; p<0.001), body mass index (29±5 kg/ m² vs 25±5 kg/m²; p=0.009) and serum albumin level (3.6±0.5 vs 3.4±0.5 g/dL; p=0.027]. Patients with RRF had lower erythropoietin [29 (39%), vs. 34 (85%); p<0.001), sevelamer [17 (22.7%) vs 24 (60%); p<0.001] and calcimimetic [9 (12%) vs 14 (35%); p=0.007] usage rates and lower ferritin [159 (88-259) ng/mL vs 323 (170-495) ng/mL; p=0.001] level. rGFR was found to be positively correlated with Hb (r=0.274; p=0.017) and nPCR in patients with RRF (r=0.251; p=0.030). Conclusion: In our study, the positive effects of RRF on the treatment of anemia, phosphorus control and nutritional status in PD patients were shown. [ABSTRACT FROM AUTHOR]

Objective: In cardiac surgery, low serum albumin level is an important risk factor that increases mortality and morbidity in the postoperative period. Diabetes mellitus may affect this clinical condition by causing albumin loss with proetinuria. In this study, the effects of preoperative albumin values and the presence of diabetes mellitus (DM) on postoperative renal failure were investigated. Method: Patients who underwent coronary artery bypass grafting between 01.01.2015-31.12.2019 in our clinic were retrospectively analyzed. Patients who received dialysis treatment in the preoperative period, whose ejection fraction was below 50%, and who underwent emergency surgery were excluded from the study. The patients were divided into 3 groups according to the serum albumin levels before surgery. Patients with serum albumin level ≥3.5 mgr/dL Group 1; those between 2.5-3.5 mg/dL Group 2; patients with ≤ 2.5 were named as Group 3. Later, these 3 groups were divided into 2 subgroups according to the presence of DM. Results: 308 patients who underwent coronary artery bypass surgery were included in the study. The demographic characteristics, peroperative data and operative data of the patients were similar. The need for renal replacement therapy was higher in Group 2 and Group 3 than in Group 1 in the postoperative period. Conclusion: Preoperative low serum albumin is a risk factor for the development of acute renal failure in the postoperative period, and the presence of DM adversely affects this condition. Close follow-up of these patients positively contributes to reducing mortality and morbidity. [ABSTRACT FROM AUTHOR]

Aim: We aimed to evaluate the nutritional status with clinical, antropometric and laboratory methods in patients who were scheduled for elective surgery. Methods: Retrospective evaluation of 90 patients in a period of 4 years was performed. Patients with tumors (group 1) were compared with controls (group 2) in regard to nutritional status. Student t-test, Mann-Whitney U test and chi-square test were used for statistical analysis. Results: The mean age of patients in group 1 (3 males, 8 females) and group 2 (35 males, 44 females) was 62.8±11.0 and 47.7±16.2 years, respectively. The mean body mass index (BMI) was 30.1±6.6. Triceps thickness and circumference of the upper mid-arm were 2.2±0.8 and 28.6±4.2 cm, respectively. All patients had a Subjective Global Assessment (SGA) score A, but two patients were classified as having moderate nutritional risk according to Nutritional Risk Screening (NRS) 2002. The mean length of hospital stay was 2.6±2.4 days. Complications were observed in four patients of group 2 and in two patients of group 1. Gender, SGA score, albumin, prealbumin, BMI, triceps thickness, circumference of the upper mid-arm and complication rates were statistically similar between the groups. There was a statistically significant difference in age, NRS 2002, gastrointestinal system findings, length of hospital stay, sedimentation and fasting blood glucose levels between the groups. Conclusion: Patients with nutritional risk can be detected using the NRS 2002. Nutritional support was necessary in 2% of all cases and in 18% of group 1 patients. However, advantages of antropometric measurements, biochemical tests, BMI and SGA could not be shown.

Objectives: Inflammation has an important role for tumor development and also associated with poor prognosis in various cancer types. Albumin and globulin are two biomarkers that can reflect inflammation. However, albumin level can be affected in many conditions. Thus, albumin-globulin ratio (AGR) was found as a more successful biomarker for reflection of inflammation compared with albumin alone. In this article, we aim that investigated to the prognostic effect of AGR in small cell lung cancer (SCLC). Materials and Methods: We analyzed the patients who were diagnosed with SCLC between 2014-2018, retrospectively. AGR was calculated by divided albumin to globulin level at the diagnosis. Cut off level for AGR was accepted as 1.2. Results: totally, 81 patients were enrolled to study. Percent of patients with AGR < 1.2 were 40.30% and AGR ≥ 1.2 were 50.30%. Patients characteristics were similar between the groups. We found that negative correlation between AGR and neutrophil-lymphocyte ratio and platelet-lymphocyte ratio, significantly. Progression free survival and overall survival were longer in AGR ≥ 1.2 group. Conclusion: AGR is a cheap and easy biomarker. Thus, it can be used for prognostic biomarker for SCLC. [ABSTRACT FROM AUTHOR]

Objective: Although crystalloid solutions are recommended as first choice for fluid replacement after cardiac surgery, abumin and synthetic colloids are used in special condition. In this study, the effects of preoperative albumin level on postoperative period and the effects of albumin on outcomes were investigated. Method: Patients who underwent cardaic surgery between 01.01.2014 and 12.31.2018 were evaluated retrospectively. Patients were divided into two groups according to preoperative albumin levels. Patients with preoperative albumin levels < 4 g/dL and ≥4 g/dL constituted Groups 1, and 2 respectively. Effects of preoperative albumin levels on early postoperative morbidity and mortality and its relationship with fluid replacement were evaluated. Results: Hypoalbuminemia persisted also during the postoperative period in patients with low preoperative albumin levels. During follow-up, 13 patients developed minor complications, of which 12 were in Group 1, and 10 had albumin replacement. Although 7 patients underwent albumin replacement 9 patients in Group 1, and 1 patient in Group 2 exited during postoperative period It was seen that preoperative albumin value under 4 g/dL increased the risk of postoperative complications 14 times and the application of albumin replacement in these patients did not provide the expected contribution to the outcome. Conclusion: Although low preoperative albumin value is associated with increased morbidity and mortality during the postoperative period, albumin replacement does not contribute positively to the outcome. In accordance with the recommendations of current guidelines, it would be appropriate to consider crystalloid solution as the first choice in cases where blood replacement is not required after cardiac surgery. [ABSTRACT FROM AUTHOR]

Aim: The aim of this study was to evaluate the prognosis value of tumor size and preoperative albumin levels in gastric cancer patients treated with postoperative ch emoradiotherapy. Patients and Methods: Patients records reviewed retrospectively. Clinicopathologic features were analyzed. 199 patients who applied to our clinic between 15.1.2010-31.12.2016 were included in this study. The primary end points of this study were to evaluate the overall survival (OS) and the disease free survival(DFS). Results: Mean follow up time was 20.43 months. Distant metastases devoloped in 50 patients and 102 patients were alive. In multivariate analyses, advanced T stage, history of smoking, preoperative albumin level less than 3.5 gr/dl and tumor size more than 8 cm were found to have poor prognostic effect on OS. Lymphovascular invasion (LVI) and tumor size were showed negative effects on DFS. For statistical analyses SPSS (statistical package for social sciences) 21.0 st atistical package was used. Conclusions: Despite recent treatment modalities the prognosis of gastric cancer is still poor and novel prognostic factors together with the current ones may be helpful to predict decision of proper treatment modalities and survival of the patients [ABSTRACT FROM AUTHOR]

In this study, it is aimed to evaluate the patient's systemic inflammatory condition, by estimating CRP, albumin, total protein values and CBC. These results were compared with inflammatory condition of the gums. In this study, a total of 20 dogs, including 10 dogs with gingivitis, and 10 healthy dogs, were used. Diagnosis was established based on the clinical findings (dental plaque, redness and edema in the gum). In history, the owners was asked if any oral care application was performed after each meal (drinking water, brushing dog's teeth, eating dental care food or giving chewing material), and if there is any mouth-related complaints (chewing difficulty, excessive saliva flow and halitosis). On physical examination; body temperature, pulse, and respiration rates were detected, submandibular lymph node was examined. From each patient and healthy dog, 5 mL blood to the tubes without coagulant, and 2 mL blood to the tubes with EDTA were taken. CRP, albumin and total protein values, and CBC were evaluated by comparing with those in healthy ones. Based on the clinical findings, mild-to-moderate gingivitis was diagnosed in patients. It was learned that patients have difficulty in chewing hard food, have halitosis and no special oral care application was done in patients after each meal, and have dental plaques. In physical examination, all of the patients have dental plaque, gingival redness and edema and halitosis. Body temperature, respiratory and pulse rates are within normal limits. There was no adenopathy in submandibular lymph node and no problems with the gums in healthy dogs. In the dogs with mild-to-moderate gingivitis and with no submandibular lymph node growth, no statistically significant changes were found in CRP, albumin, total protein values and the CBC. [ABSTRACT FROM AUTHOR]

Aim: We aimed to evaluate the nutritional status with clinical, antropometric and laboratory methods in patients who were scheduled for elective surgery. Methods: Retrospective evaluation of 90 patients in a period of 4 years was performed. Patients with tumors (group 1) were compared with controls (group 2) in regard to nutritional status. Student t-test, Mann-Whitney U test and chi-square test were used for statistical analysis. Results: The mean age of patients in group 1 (3 males, 8 females) and group 2 (35 males, 44 females) was 62.8±11.0 and 47.7±16.2 years, respectively. The mean body mass index (BMI) was 30.1±6.6. Triceps thickness and circumference of the upper mid-arm were 2.2±0.8 and 28.6±4.2 cm, respectively. All patients had a Subjective Global Assessment (SGA) score A, but two patients were classified as having moderate nutritional risk according to Nutritional Risk Screening (NRS) 2002. The mean length of hospital stay was 2.6±2.4 days. Complications were observed in four patients of group 2 and in two patients of group 1. Gender, SGA score, albumin, prealbumin, BMI, triceps thickness, circumference of the upper mid-arm and complication rates were statistically similar between the groups. There was a statistically significant difference in age, NRS 2002, gastrointestinal system findings, length of hospital stay, sedimentation and fasting blood glucose levels between the groups. Conclusion: Patients with nutritional risk can be detected using the NRS 2002. Nutritional support was necessary in 2% of all cases and in 18% of group 1 patients. However, advantages of antropometric measurements, biochemical tests, BMI and SGA could not be shown. [ABSTRACT FROM AUTHOR]

Amaç: Yoğun bakım hastalarının beklenilen ölüm oranlarının hesaplanması, mevcut tıbbi durumu acil teşhis ve tedavi gerektirecek hastaların hızlıca belirlenmesi, yoğun bakımların standardizasyonu, hizmet kalitesinin değerlendirilmesi ve sağlanması açısından önemlidir. Bu nedenle mortalite tahmininde geliştirilen ölçekler kullanılmaktadır. Bu çalışmada mortalite prediktörü olabilecek enflamasyon belirteçlerinden C-reaktif protein, prokalsitonin, albumin ve beyaz küre değerlerinin mortalite tahminindeki etkinliğinin araştırılması amaçlandı. Gereç ve Yöntem: Dokuz yataklı, üçüncü basamak reanimasyon yoğun bakım ünitesine altı aylık dönemde takip edilen, 18 yaş üstü, çalışmaya katılmayı kabul eden hastalar prospektif ve gözlemsel olarak incelendi. Hastaların demografik, klinik ve laboratuvar verileri kaydedildi. APACHE-II (Acute Physiology and Chronic Health Evaluation-II) skoru hesaplandı. Skor sonuçları ve yatış anındaki laboratuvar verilerinin yoğun bakım yatış süresi ve yoğun bakım tedavisi sonlanımı ile ilişkisi değerlendirildi. Bulgular: Çalışmaya 126 hasta dahil edildi. Hastalara ait demografik veriler Tablo 1’de verilmiştir. C-reaktif protein, yoğun bakım yatış süresi (p=0,044) ve APACHE-II skoru (p=0,02) ile; prokalsitonin de APACHE II skoru ile (p=0,001) korele bulundu. Tüm hastaların verileri değerlendirildiğinde C-reaktif protein (p<0,001) ve prokalsitonin (p=0,004) düzeyi, ölen hasta grubunda daha yüksek idi. Cerrahi grubundaki hastalar acil ve elektif cerrahi hastaları olarak değerlendirildiğinde; acil cerrahi grubunda, ölen ve sağ kalan hastalardaki C-reaktif protein (p>0,05) ve prokalsitonin (p>0,05) düzeyleri mortalite prediktörü değilken, elektif cerrahi grubunda ölen hastalarda C-reaktif protein (p=0,011) ve prokalsitonin (p=0,017) değerlerinin mortalite açısından belirleyici olduğu saptandı. Medikal hasta grubunda ise ölen hastalarda yüksek C-reaktif protein değeri (p=0,001) ve düşük albumin (p<0,001) değerinin mortalite açısından belirleyici olduğu gösterildi (Tablo 2). Sonuç: Yoğun bakım ünitesinde, komorbid durumu bulunan ve yüksek mortalite olasılığına sahip hastaların takip ve tedavisi yapılmaktadır. Bu hastalarda enflamasyon sıklıkla gelişebilmekte, bu durumda da hızlı tanı ve tedavi hayati öneme sahiptir. Bu amaçla özgül belirteçlere başvurulmaktadır. Elektif cerrahi sonrasında yoğun bakıma kabul edilen hastalarda C-reaktif protein ve prokalsitonin değerlerinin; medikal hasta grubunda ise C-reaktif protein ve albumin değerleri ile mortalite tahmini yapılabileceğini düşünmekteyiz. Bu belirteçlerin APACHE-II skoru gibi mortalite tahmin ölçekleri ile birlikte değerlendirilmesiyle, daha yüksek olasılıkla mortalite tahmini yapılabileceğini düşünmekteyiz. Bu çalışmanın mortalite tahmini üzerine yapılacak yeni çalışmalar için yol gösterici olacağını düşünmekteyiz. [ABSTRACT FROM AUTHOR]

Introduction: Serum albumin, albumin-globulin ratio (AGR), neutrophil/lymphocyte(N / L) levels in patients with gastric carcinoma were investigated on survival impact. Methods: This study was planned as a pilot study. Biochemical parameters of 46 patients were obtained from archive retrospectively. AGR levels were calculated by AGR =albumin/Total Protein- Albumin formula. They were sorted by descending, AGR was evaualted with low and high by using ROC. Albumin and N/L were divided similarly. Results: AGR cut-off value was 1.295 with ROC, in ROC: 0.543 (62.5% sensitivity, 50% specificity). Overall survival's detected 25.83 ± 26.58 months in AGR <1.295, 27.36±2:18 months in AGR 1.295 as (p = 0.706, 95% CI: 0295-0791) . A longer overall survival's detected in 1.295 high AGR group by Kaplan-Meier. Cut-off values according to ROC of albumin level's 4.05 mg/dL in the ROC:0.545, (50% sensitivity, 58.5% specificity). The overall survival's detected 22.3±21:22 months, in <4:05 mg / dL albumin, 29.85±25.69 months in 4.05mg/dL albumin (p=0.524, 95% CI:0195-0660). A longer overall survival's detected in <4:05mg/dL albumin by Kaplan-Meier. Cut-off value according to ROC of N/L level's 2.445 in ROC:0.495, (50% sensitivity, 60.5% specificity).The overall survival's detected 32.21±29.36 months in >2.445 N/L, 22:59±18.76 months in < 2.445 N/L(p=0.965, 95% CI:0.247-0.748). A longer overall survival's determined in >2.445N/L by Kaplan-Meier. According to logistic regression; AGR (p = 0,643, HR:1.484, 95%CI:0.279-7.892), N/L (p=0.599, H: 1.520, 95% CI:0.318-7.260), albumin levels (p =0.771, H:1.275, 95% CI:0.247-6.576), didn't show any association between mortality. Discussion: AGR, N/L, albumin levels are useful parameters to predictive survival in gastric cancer mortality. [ABSTRACT FROM AUTHOR]

Objective: Guillain-Barre syndrome (GBS) is an immune- mediated disorder of peripheral nerves resulting as acute inflammatory demyelinating polyradiculoneuropathy. GBS has a heterogeneous clinical course and laboratory findings. Acute onset and progressive course, and is usually associated with a good prognosis but some forms have a poor prognosis. Factors that can affect the prognosis of GBS have been investigated in several studies. Assessment of poor prognostic factors of GBS plays a vital role in the management and monitorization of patients. Methods: In this retrospective study of patients admitted to the acute phase of GBS removing clinical and laboratory profiles and was planned to investigate the prognostic factors. Results: Totally 23 patients (Female/male: 16/7) were recruited. Mean age was 47 (range: 17-70) years. Statistically significant poor prognostic factors were advanced age (p=0.042), erythrocyte sedimentation rate (p=0.027) and serum albumin level (p=0.007). Conclusion: Advanced age, increased ESR and decreased albumin levels were found as poor prognostic factors in GBS. [ABSTRACT FROM AUTHOR]

Objective: In this study we aimed to investigate the relationship between the presence of atrial fibrillation (AF) and serum albumin levels which is a negative acute phase protein. Methods: This study is single-center and has a retrospective design. We included patients with a diagnosis of rheumatic mitral stenosis (RMS) and having serum albumin levels between 2011 and 2014. Then the patients were divided into two groups according to presence of AF. Clinical and laboratory data of these two groups were compared. Results: The study included 74 patients having the inclusion criteria. Seventy seven percent of patients were female, mean age was 44±12 years. Atrial fibrillation was detected in 34% of the patients. Hypertension presence, age, left atrial diameter, creatinine, C-reactive protein were higher in AF group while serum albumin, left ventricular ejection fraction and mean transmitral gradient was significantly lower. Multivariate logistic regression analysis showed that aging, lower albumin and anemia (respectively, odds ratio [OR]: 1.124, 95% confidence interval [CI], [1.049-1.205], OR: 0.022, 95% CI; [0.002-0.268] and OR: 5.941, 95% CI; [1.031-34.222]) were found to be independent predictors of AF presence. Conclusion: Lower serum albümin levels, aging and anemia were associated with the presence of AF in patients with RMD. Low albümin levels can be a surrogate marker of increased inflammation and may serve as a risk factor for AF development. [ABSTRACT FROM AUTHOR]

Objectives: The aim of this study is to investigate the effects of different concentrations of albumin, which has antioxidant characteristics on renal antioxidant levels and renal functions in rats with sepsis. Materials and Methods: Twenty-eight adult male Sprague-Dawley rats were divided into 4 groups. No agent was implemented to Group K. Group S received 30 ml/kg of saline infusion for 90 min, Group A5 received 15 ml/kg of 5% albumin infusion for 90 min and Group A25 received 3 ml/kg of 25% albumin infusion for 45 min. At the end of the 18th hour, bilateral nephrectomy was performed. Blood samples were taken to determine blood urea nitrogen, creatinine and albumin levels. Kidney tissue samples were dissected to measure the levels of free oxygen radicals and antioxidants. Results: Better renal function, higher levels of glutathione and malondialdehyde with lower myeloperoxidase levels were obtained in septic rats following treatment with 2 different concentrations of albumin. In Group A25, blood urea nitrogen and renal glutathione levels were significantly higher than in Group A5. Conclusion: We are of the opinion that the rapid infusion of 25% albumin may prevent or delay the occurrence of renal dysfunction in patients with sepsis. [ABSTRACT FROM AUTHOR]