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1. Synthesis of Vixotrigine, a Use-Dependent Sodium Channel Blocker. Part 1: Development of Bulk Supply Routes to Enable Proof of Concept

Author

Michael Williams, William F. Kiesman, Gerard M. P. Giblin, Adrian Heseltine, David T. MacPherson, James A. Ramsden, Ravi Vadali, and David R Witty

Subjects
Use dependent, Sodium channel blocker, Chemistry, Proof of concept, Organic Chemistry, Physical and Theoretical Chemistry, Combinatorial chemistry
Abstract

Two syntheses of vixotrigine are reported. Route 1, adapted from the medicinal chemistry route, enabled rapid delivery of drug substance for clinical development. Route 2, which was developed to ad...

Published
2020
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