Search

Introduction. Support systems currently used in modern cardiac surgery to provide partial or complete, permanent or temporary replacement of cardiac function are frequently characterized by large dimensions, thus requiring major surgical interventions. Low invasiveness can be ensured by reducing the size of the implanted part of such systems, allowing these devices to be inserted through the femoral artery.Aim. Development of a minimally invasive micropump system to support blood circulation.Materials and methods. Based on the analysis of implementation of micropump circulatory support systems (MCSS), the configuration, operational principles and main components of such a system were determined. When designing a micropump, as a unit defining the weight and size parameters of the entire system, numerical and experimental methods were used to optimize its flow path based on the condition of minimizing blood injury and thrombus formation. The lubrication and cooling system was developed by solving the thermodynamic problem of heat removal. The electronic control unit was developed on the basis of accumulated experience in the design and operation of control units for circulatory support systems.Results. A micropump with a diameter of 6.5 mm and a length of 43 mm with the required hydro- and hemodynamic parameters was designed. The device ensures minimal trauma and thrombus formation. The main MCSS parameters, as well as its main components (electric drives, lubrication and cooling systems), were defined. The configuration and operational principles of the electronic control unit (ECU), consisting in a microprocessor-based control system with feedback, were developed. The ECU built-in software manages the rotational speed of the electric drives of the micropump and coolant supply pump in the required range. In addition, the software is used to measure, display and register the MCSS operational parameters, as well as to monitor their operation in the required ranges and to exchange data between the ECU and the PC.Conclusion. All the necessary documentation for the MCSS nodes and components was prepared. These nodes and components ensure the hydro- and hemodynamic parameters required for the use of the developed minimally invasive micropump system. Future work will address the stages of MCSS assembly and debugging.

Previously derived Faraday rotation constraints on the volume-filling intergalactic magnetic field (IGMF) have used analytic models that made a range of simplifying assumptions about magnetic field evolution in the intergalactic medium and did not consider the effect of baryonic feedback on large-scale structures. In this work we revise existing Faraday rotation constraints on the IGMF using a numerical model of the intergalactic medium from the IllustrisTNG cosmological simulation that includes a sophisticated model of the baryonic feedback. We use the IllustrisTNG model to calculate the rotation measure and compare the resulting mean and median of the absolute value of the rotation measure with data from the NRAO VLA Sky Survey (NVSS). The numerical model of the intergalactic medium includes a full magneto-hydrodynamic model of the compressed primordial magnetic field as well as a model of the regions where the magnetic field is not primordial, but is rather produced by the process of baryonic feedback. Separating these two types of regions, we are able to assess the influence of the primordial magnetic field on the Faraday rotation signal. We find that by correcting for regions of compressed primordial field and accounting for the fact that part of the intergalactic medium is occupied by magnetic fields spread by baryonic feedback processes rather than by the primordial field relaxes the Faraday rotation bound by a factor of $\simeq 3$. This results in $B_0, Replaced with the published version

Solid organ transplant recipients (SOTRs) are less likely to mount an antibody response to SARS-CoV-2 mRNA vaccines. Understanding risk factors for impaired vaccine response can guide strategies for antibody testing and additional vaccine dose recommendations.Using a nationwide observational cohort of 1031 SOTRs, we created a machine learning model to explore, identify, rank, and quantify the association of 19 clinical factors with antibody responses to 2 doses of SARS-CoV-2 mRNA vaccines. External validation of the model was performed using a cohort of 512 SOTRs at Houston Methodist Hospital.Mycophenolate mofetil use, a shorter time since transplant, and older age were the strongest predictors of a negative antibody response, collectively contributing to 76% of the model's prediction performance. Other clinical factors, including transplanted organ, vaccine type (mRNA-1273 versus BNT162b2), sex, race, and other immunosuppressants, showed comparatively weaker associations with an antibody response. This model showed moderate prediction performance, with an area under the receiver operating characteristic curve of 0.79 in our cohort and 0.67 in the external validation cohort. An online calculator based on our prediction model is available at http://transplantmodels.com/covidvaccine/ .Our machine learning model helps understand which transplant patients need closer follow-up and additional doses of vaccine to achieve protective immunity. The online calculator based on this model can be incorporated into transplant providers' practice to facilitate patient-centric, precision risk stratification and inform vaccination strategies among SOTRs.

Background Pre-liver transplant (LT) sarcopenia is associated with poor survival. Methods exist for measuring body composition with use of CT scans; however, it is unclear which components best predict post-LT outcomes. Purpose To quantify the association between abdominal CT-based body composition measurements and post-LT mortality in a large North American cohort. Materials and Methods This was a retrospective cohort of adult first-time deceased-donor LT recipients from 2009 to 2018 who underwent pre-LT abdominal CT scans, including at the L3 vertebral level, at Johns Hopkins Hospital. Measurements included sarcopenia (skeletal muscle index [SMI]50 in men and39 in women), sarcopenic obesity, myosteatosis (skeletal muscle CT attenuation41 mean HU for body mass index [BMI]25 and33 mean HU for BMI ≥25), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and VAT/SAT ratio. Covariates in the adjusted models were selected with use of least absolute shrinkage and selection operator regression with lambda chosen by means of 10-fold cross-validation. Cox proportional hazards models were used to quantify associations with post-LT mortality. Model discrimination was quantified using the Harrell C-statistic. Results A total of 454 recipients (median age, 57 years [IQR, 50-62 years]; 294 men) were evaluated. In the adjusted model, pre-LT sarcopenia was associated with a higher hazard ratio (HR) of post-LT mortality (HR, 1.6 [95% CI: 1.1, 2.4]; C-statistic, 0.64

High energy collisions at the High-Luminosity Large Hadron Collider (LHC) produce a large number of particles along the beam collision axis, outside of the acceptance of existing LHC experiments. The proposed Forward Physics Facility (FPF), to be located several hundred meters from the ATLAS interaction point and shielded by concrete and rock, will host a suite of experiments to probe standard model (SM) processes and search for physics beyond the standard model (BSM). In this report, we review the status of the civil engineering plans and the experiments to explore the diverse physics signals that can be uniquely probed in the forward region. FPF experiments will be sensitive to a broad range of BSM physics through searches for new particle scattering or decay signatures and deviations from SM expectations in high statistics analyses with TeV neutrinos in this low-background environment. High statistics neutrino detection will also provide valuable data for fundamental topics in perturbative and non-perturbative QCD and in weak interactions. Experiments at the FPF will enable synergies between forward particle production at the LHC and astroparticle physics to be exploited. We report here on these physics topics, on infrastructure, detector, and simulation studies, and on future directions to realize the FPF’s physics potential.

The origin of menopause is mysterious and difficult to explain in terms of evolutionary theory. Menopause is described in humans and in four cetacean species. Natural selection cannot act on a trait that appears after the end of reproduction; therefore, it cannot be formed by the classical selection mechanism. All the proposed theories of the onset of menopause, adaptive and non-adaptive, can explain the benefits of menopause, but are completely untenable from the point of view of the theory of evolution and do not answer the main question - how did it arise. We propose a hypothesis based on the assertion that menopause is a byproduct of the rapid increase in the size of the cerebral cortex during the formation of Homo sapiens. Genes associated with the development of congenital microcephaly, which are responsible for the development of the cerebral cortex, were identified, and clear traces of natural selection were found in them, and a powerful evolutionary process continues up to the present. Most products of these genes are associated with the process of formation of the cell division spindle, both in the process of mitosis and meiosis. We hypothesize that the rapid evolutionary process that led to the growth of the cerebral cortex in humans, as a side effect, led to the formation of a high frequency of aneuploidy in oocytes. A similar process has also led to the formation of menopause in cetaceans.

Experiments on online marketplaces and social networks suffer from interference, where the outcome of a unit is impacted by the treatment status of other units. We propose a framework for modeling interference using a ubiquitous deployment mechanism for experiments, staggered roll-out designs, which slowly increase the fraction of units exposed to the treatment to mitigate any unanticipated adverse side effects. Our main idea is to leverage the temporal variations in treatment assignments introduced by roll-outs to model the interference structure. We first present a set of model identification conditions under which the estimation of common estimands is possible and show how these conditions are aided by roll-out designs. Since there are often multiple competing models of interference in practice, we then develop a model selection method that evaluates models based on their ability to explain outcome variation observed along the roll-out. Through simulations, we show that our heuristic model selection method, Leave-One-Period-Out, outperforms other baselines. We conclude with a set of considerations, robustness checks, and potential limitations for practitioners wishing to use our framework.

The beta spectrum of the main transition of the beta-decay of 171Tm was measured using a double focalizing spectrometer. The instrument was lately improved in order to reduce its low energy threshold to 34 keV. We used the spectrometer to measure the beta spectrum end-point energy of the main transition of 171Tm decay using the Kurie plot formalism. We report a new value of 97.60(38) keV, which is in agreement with previous measurements. In addition, the spectrum shape was compared with the xi-approximation calculation where the shape factor is equal to 1 and good agreement was found between the theory and the measurement at the 1% level.

OBJECTIVE To evaluate disease flare and postvaccination reactions (reactogenicity) in patients with rheumatic and musculoskeletal diseases (RMDs) following 2-dose SARS-CoV-2 messenger RNA (mRNA) vaccination. METHODS RMD patients (n = 1,377) who received 2-dose SARS-CoV-2 mRNA vaccination between December 16, 2020 and April 15, 2021 completed questionnaires detailing local and systemic reactions experienced within 7 days of each vaccine dose (dose 1 and dose 2), and 1 month after dose 2, detailing any flares of RMD. Associations between demographic/clinical characteristics and flares requiring treatment were evaluated using modified Poisson regression. RESULTS Among the patients, 11% reported flares requiring treatment; there were no reports of severe flares. Flares were associated with prior SARS-CoV-2 infection (incidence rate ratio [IRR] 2.09, P = 0.02), flares in the 6 months preceding vaccination (IRR 2.36, P

BACKGROUND: While several studies have observed that solid organ transplant recipients experience diminished antibody responses to SARS-CoV-2 mRNA vaccination, data specific to heart and lung transplant (HT/LT) recipients remains sparse. METHODS: US adult HT and LT recipients completed their vaccine series between January 7 and April 10, 2021. Reactogencity and SARS-CoV-2 anti-spike antibody were assessed after a priming dose (D1) and booster dose (D2). Modified Poisson regression with robust variance estimator was used to evaluate associations between participant characteristics and antibody development. RESULTS: Of 134 heart recipients, there were 38% non-responders (D1-/D2-), 48% booster responders (D1-/D2+), and 14% priming dose responders (D1+/D2+). Of 103 lung recipients, 64% were non-responders, 27% were booster responders, and 9% were priming dose responders. Lung recipients were less likely to develop antibodies (p < .001). Priming dose antibody response was associated with younger recipient age (p = .04), transplant-to-vaccination time ≥6 years (p < .01), and lack of anti-metabolite maintenance immunosuppression (p < .001). Pain at injection site was the most commonly reported reaction (85% after D1, 76% after D2). Serious reactions were rare, the most common being fatigue (2% after D1 and 3% after D2). No serious adverse events were reported. CONCLUSIONS: HT and LT recipients experienced diminished antibody response following vaccination; reactogenicity was comparable to that of the general population. LT recipients may exhibit a more impaired antibody response than HT recipients. While current recommendations are to vaccinate eligible candidates and recipients, further studies characterizing the cell-mediated immune response and clinical efficacy of these vaccines in this population are needed.

The BDF/SHiP collaboration has proposed a general-purpose intensity-frontier experimental facility operating in beam-dump mode at the CERN SPS accelerator to search for feebly interacting GeV-scale particles and to perform measurements in neutrino physics. BDF/SHiP complements the world-wide program of New Physics searches by exploring a large region of parameter space which cannot be addressed by other experiments, and which reaches several orders of magnitude below existing bounds. The SHiP detector is sensitive both to decay and scattering signatures of models with heavy neutral leptons, dark photons, dark scalars, axion-like particles, light dark matter and other feebly interacting particles. In neutrino physics, BDF/SHiP can perform unprecedented measurements with tau neutrinos and neutrino-induced charm production. Following the Technical Proposal submitted in 2015, the subsequent three-year Comprehensive Design Study (CDS), and the recent study of BDF/SHiP in existing beam facilities around the SPS, this paper restates the motivation and reports on the implementation and physics performance of BDF/SHiP in the SPS ECN3 high-intensity beam facility.

Acute kidney injury (AKI) and frailty are major drivers of outcomes among patients with cirrhosis. What is unknown is the impact of physical frailty on the development of AKI. We included adults with cirrhosis without hepatocellular carcinoma listed for liver transplantation at nine US centers (n=1,033). Frailty was assessed using the Liver Frailty Index (LFI); "frail" was defined by LFI≥4.2. Chronic kidney disease as a baseline estimated glomerular filtration rate

Supplemental Digital Content is available in the text., Background. We studied the safety and reactogenicity SARS-CoV-2 mRNA vaccines in transplant recipients because immunosuppressed patients were excluded from vaccine trials. Methods. US transplant recipients were recruited into this prospective cohort study through social media; those who completed the full vaccine series between December 9, 2020 and March 1, 2021 were included. We collected demographics, medical history, and safety information within 7 d after doses 1 and 2 (D1, D2). Associations between characteristics and reactions were evaluated using modified Poisson regression. Results. We studied 741 transplant recipients who underwent BNT162b2 (54%) or mRNA-1273 (46%) vaccination. Median (interquartile range) age was 60 (44–69) y, 57% were female, and 10% were non-White. Although local site reactions decreased after D2 (85% D1 versus 78% D2, P

Prior studies have demonstrated a decreased humoral response in solid organ transplant recipients (SOTRs) to SARS-CoV-2 mRNA vaccination (17% antibody response after dose 1, 54% after dose 2) as compared to the general population (100%). However, these studies were dominated by kidney transplant recipients, and included only a small percentage of liver transplant (LT) recipients (19.6%).(1-4) Since LT recipients often receive milder induction and maintenance immunosuppression, they may have a more robust humoral response. To investigate this, we studied SARS-CoV-2 antibody development in a cohort of LT recipients who completed a two-dose mRNA vaccine series of either mRNA-1273 (Moderna) or BNT162b2 (Pfizer-BioNTech).

An axial micropump for left ventricular support developed by our team is described. The main requirements for the size and weight of a minimally invasive micropump are formulated. The geometry of the micropump and its effect on the pressure head and energy characteristics are considered. The micropump design and its pressure head and energy characteristics are described.

Following the outbreak of coronavirus disease 2019 (COVID-19) in the United States, the number of kidney waitlist additions and living-donor and deceased-donor kidney transplants (LDKT/DDKT) decreased substantially but began recovering within a few months. Since then, there have been several additional waves of infection, most notably, the Delta and Omicron surges beginning in August and December 2021, respectively.Using SRTR data, we compared observed waitlist registrations, waitlist mortality, waitlist removal due to deteriorating condition, LDKT, and DDKT over 5 distinct pandemic periods to expected events based on calculations from preepidemic data while accounting for seasonality and secular trends.Although the number of daily waitlist additions has been increasing since May 2020, the size of the active waitlist has consistently declined, reaching a minimum of 52 556 on February 27, 2022. The recent Omicron surge knocked LDKT from 25% below baseline (incidence rate ratio [IRR] =Despite exceptionally high COVID-19 incidence during the Omicron wave, the transplant system responded similarly to prior waves that imposed a lesser disease burden, demonstrating the transplant system's growing adaptations and resilience to this now endemic disease.

Postacute sequelae of SARS-CoV-2 infection (PASC) is an increasingly recognized phenomenon and manifested by long-lasting cognitive, mental, and physical symptoms beyond the acute infection period. We aimed to estimate the frequency of PASC symptoms in solid organ transplant (SOT) recipients and compared their frequency between those with SARS-CoV-2 infection requiring hospitalization and those who did not require hospitalization.A survey consisting of 7 standardized questionnaires was administered to 111 SOT recipients with history of SARS-CoV-2 infection diagnosed4 wk before survey administration.Median (interquartile range) time from SARS-CoV-2 diagnosis was 167 d (138-221). Hospitalization for SARS-CoV-2 infection was reported in 33 (30%) participants. Symptoms after the COVID episode were perceived as following: significant trauma (53%), cognitive decline (50%), fatigue (41%), depression (36%), breathing problems (35%), anxiety (23%), dysgeusia (22%), dysosmia (21%), and pain (19%). Hospitalized patients had poorer median scores in cognition (Quick Dementia Rating System survey score: 2.0 versus 0.5, P = 0.02), quality of life (Health-related Quality of Life survey: 2.0 versus 1.0, P = 0.015), physical health (Global physical health scale: 10.0 versus 11.0, P = 0.005), respiratory status (Breathlessness, Cough and Sputum Scale: 1.0 versus 0.0, P = 0.035), and pain (Pain score: 3 versus 0 out of 10, P = 0.003). Among patients with infection6 mo prior, some symptoms were still present as following: abnormal breathing (42%), cough (40%), dysosmia (29%), and dysgeusia (34%).SOT recipients reported a high frequency of PASC symptoms. Multidisciplinary approach is needed to care for these patients beyond the acute phase.

Acknowledgments We thank the participants of the FPF meetings and the Snowmass working groups for discussions that have contributed both directly and indirectly to this study. We gratefully acknowledge the invaluable support of the CERN Physics Beyond Colliders study group and the work of CERN technical teams related to civil engineering studies (SCE-DOD), safety discussions (HSE-OHS, HSE-RP, EP-DI-SO), integration (EN-ACE), and discussions on services (EN-CV, EN-EL, EN-AA) and simulations (SY-STI). The work by J Alameddine, W Rhode, T Ruhe, and A Sandrock has been supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Collaborative Research Center SFB 876 and SFB 1491. L A Anchordoqui is supported by the US National Science Foundation (NSF) Grant PHY-2112527. T Araki is supported by JP18H01210. A Ariga is supported by JSPS KAKENHI Grant JP20K23373 and the European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme (Grant 101002690). T Ariga acknowledges support from JSPS KAKENHI Grant JP19H01909. K Asai is supported by JSPS KAKENHI Grant JP19J13812 and JP21K20365. A Bacchetta and F G Celiberto acknowledge support from the INFN/NINPHA project. P Bakhti and M Rajaee are supported by the National Research Foundation of Korea (NRF-2020R1I1A3072747). B Barman received funding from the Patrimonio Autónomo—Fondo Nacional de Financiamiento para la Ciencia, la Tecnología y la Innovación Francisco José de Caldas (MinCiencias—Colombia) Grant 80740-465-2020 and the European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant Agreement No. 860881-HIDDeN. The work of B Batell is supported by the US Department of Energy (DOE) Grant DE–SC0007914. The work of A Berlin, T J Hobbs, S Hoeche, and J G Morfín was supported by the Fermi National Accelerator Laboratory (Fermilab), a US DOE, Office of Science, HEP User Facility. Fermilab is managed by Fermi Research Alliance, LLC (FRA), acting under Contract DE-AC02-07CH11359. M Becker, E Copello and J Harz acknowledge support from the DFG Emmy Noether Grant HA 8555/1-1. E Copello acknowledges also support from the DFG Collaborative Research Centre 'Neutrinos and Dark Matter in Astro- and Particle Physics' (SFB 1258). E Bertuzzo acknowledges financial support from FAPESP Contracts 2015/25884-4 and 2019/15149-6 and is indebted to the Theoretical Particle Physics and Cosmology group at King's College London for hospitality. The work of J Bian and W Wu is supported in part by US DOE Grant DE-SC0009920 and Heising-Simons Foundation Grant 2022-3319. The work of A Boyarsky and M Ovchynnikov is supported by the ERC under the European Union's Horizon 2020 Research and Innovation Programme (GA 694896). A Carmona acknowledges funding from the European Union's Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement No. 754446 and UGR Research and Knowledge Transfer Found—Athenea3i. A Carmona also acknowledges partial support by the Ministry of Science and Innovation and SRA (10.13039/501100011033) Grant PID2019-106087GB-C22 and by the Junta de Andalucía Grant A-FQM-472-UGR20. F G Celiberto thanks the Università degli Studi di Pavia for the warm hospitality. The work of G Chachamis was supported by the Fundação para a Ciência e a Tecnologia (Portugal) under Project CERN/FIS-PAR/0024/2019 and Contract 'Investigador auxiliar FCT—Individual Call/03216/2017'. The work of M Citron and D Stuart is supported by US DOE Grant DE-SC0011702. The work of L Darme is supported by the European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant Agreement 101028626. P B Denton acknowledges support from the US DOE Grant Contract DE-SC0012704. The work of P S Bhupal Dev was supported in part by the US DOE Grant DE-SC0017987. The research activities of K R Dienes were supported in part by the US DOE Grant DE-FG02-13ER41976/DE-SC0009913 and also by the US NSF through its employee IR/D program. M V Diwan acknowledges support from the US DOE Grant Contract DE-SC0012704. Y Du and J H Yu are supported in part by National Key Research and Development Program of China Grant 2020YFC2201501, and the National Science Foundation of China (NSFC) under Grants 12022514, 11875003 and 12047503, and CAS Project for Young Scientists in Basic Research YSBR-006, and the Key Research Program of the CAS Grant XDPB15. The work of B Dutta and S Ghosh are supported in part by the US DOE Grant DE-SC0010813. The work of S Ghosh is also supported in part by National Research Foundation of Korea (NRF)'s Grants, Grant 6N021413. Y Farzan has received financial support from Saramadan Contract ISEF/M/400279 as well as from the European Union's Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie Grant Agreement 860881-HIDDeN. The work of J L Feng is supported in part by US NSF Grants PHY-1915005 and PHY-2111427, Simons Investigator Award #376204, Simons Foundation Grant 623683, and Heising-Simons Foundation Grants 2019-1179 and 2020-1840. M Fieg is supported in part by US NSF Grant PHY-1915005 and by NSF Graduate Research Fellowship Award DGE-1839285. A L Foguel is supported by FAPESP Contract 2020/00174-2. The work of P Foldenauer is supported by the UKRI Future Leaders Fellowship DARKMAP. The work of S Foroughi-Abari and A Ritz is supported in part by NSERC, Canada. The work of J-F Fortin is supported in part by NSERC, Canada. A Friedland is supported by the US DOE Grant DE-AC02-76SF00515. E Fuchs acknowledges support by the DFG Germany's Excellence Strategy—EXC-2123 'QuantumFrontiers'—390837967. M Fucilla, M M A Mohammed, and A Papa acknowledge support from the INFN/QFT@COLLIDERS project. A Garcia acknowledges support from the European Union's H2020-MSCA Grant Agreement 101025085. C A García Canal and S J Sciutto acknowledge support from CONICET and ANPCyT M V Garzelli acknowledges support the from German BMBF Contract 05H21GUCCA. V P Goncalves was partially financed by the Brazilian funding agencies CNPq, CAPES, FAPERGS and INCT-FNA (Process Number 464898/2014-5). S Goswami acknowledges the J C Bose Fellowship (JCB/2020/000011) of Science and Engineering Research Board of Department of Science and Technology, Government of India. The work of M Guzzi is supported by US NSF Grant PHY-2112025. L Harland-Lang thanks the Science and Technology Facilities Council (STFC) for support via Grant Award ST/L000377/1. The work of S P Harris is supported by the US DOE Grant DE-FG02-00ER41132 as well as the US NSF Grant PHY-1430152 (JINA Center for the Evolution of the Elements). J C Helo acknowledge support from Grant ANID FONDECYT-Chile 1201673 and ANID—Millennium Science Initiative Program ICN2019-044. The work of M Hirsch is supported by the Spanish Grants PID2020-113775GB-I00 (AEI/10.13039/501100011033) and PROMETEO/2018/165 (Generalitat Valenciana). The work of A Hryczuk and M Laletin is supported by the National Science Centre, Poland, research Grant 2018/31/D/ST2/00813. The research activities of F Huang are supported by the International Postdoctoral Exchange Fellowship Program and in part by US NSF Grant PHY-1915005. A Ismail is supported by NSERC (Reference Number 557763) and by US NSF Grant PHY-2014071. Y S Jeong acknowledges support from the National Research Foundation of Korea (NRF) grant funded by the Korea government through Ministry of Science and ICT Grant 2021R1A2C1009296. K Jodlowski and L Roszkowski are supported by the National Science Centre, Poland, research Grant 2015/18/A/ST2/00748. S R Klein is supported in part by the US NSF Grant PHY-1307472 and the US DOE Contract DE-AC-76SF00098. F Kling and P Quílez are supported by the DFG under Germany's Excellence Strategy—EXC 2121 Quantum Universe—390833306. P Ko is supported in part by KIAS Individual Grant PG021403 and by National Research Foundation of Korea (NRF) Grant NRF-2019R1A2C3005009. S Kulkarni is supported by the Austrian Science Fund Elise-Richter Grant V592-N27. The work of J Kumar is supported in part by US DOE Grant DE-SC0010504. J-L Kuo is supported by US NSF Theoretical Physics Program, Grant PHY-1915005. The work of C Le Roux and K Zapp is part of a project that has received funding from the ERC under the European Union's Horizon 2020 Research and Innovation Programme (Grant Agreement 803183, collectiveQCD). The work of H-S Lee was supported in part by the National Research Foundation of Korea (NRF-2021R1A2C2009718). S J Lee was supported by the Samsung Science and Technology Foundation. Ji Li is supported by the National Natural Science Foundation of China Grant 11905149. K-F Lyu and Z Liu are supported in part by the US DOE Grant DE-SC0022345. The work of R Maciula and A Szczurek was partially supported by the Polish National Science Centre under Grant 2018/31/B/ST2/03537. R Mammen Abraham and A Ismail acknowledge support from the US DOE Grant DE-SC0016013. M R Masouminia is supported by the UK Science and Technology Facilities Council (Grant ST/P001246/1). The work of J McFayden was supported by the Royal Society Fellowship Grant URF R1 201519. The work of O Mikulenko is supported by the NWO Physics Vrij Programme 'The Hidden Universe of Weakly Inter-acting Particles' with Project Number 680.92.18.03 (NWO Vrije Programma), which is (partly) financed by the Dutch Research Council (NWO). P Nadolsky and F Olness acknowledge support through US DOE Grant DE-SC0010129. E R Nocera thanks the STFC for support by the Grant Awards ST/P000630/1and ST/T000600/1. The work of N Okada is supported by the US DOE Grant DE-SC0012447. V Pandey acknowledges the support from US DOE Grant DE-SC0009824. The work of D Raut is supported by the US DOE Grant DE-SC0013880. P Reimitz acknowledges financial support from FAPESP Contract 2020/10004-7. M H Reno is supported in part by US DOE Grant DE-SC-0010113. The work of J Rojo is partly supported by the Dutch Research Council (NWO). L Roszkowski and S Trojanowski are supported by the grant 'AstroCeNT: Particle Astrophysics Science and Technology Centre' carried out within the International Research Agendas programme of the Foundation for Polish Science financed by the European Union under the European Regional Development Fund. S Trojanowski is also supported in part by the Polish Ministry of Science and Higher Education through its scholarship for young and outstanding scientists (Decision No. 1190/E-78/STYP/14/2019). S Trojanowski is also supported in part from the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No. 952480 (DarkWave 24 project). I Sarcevic is supported by US DOE Grant DOE DE-SC-0009913. The work of L Shchutska is supported by the ERC under the European Union's Horizon 2020 Research and Innovation Programme (GA 758316). The work of T Shimomura is supported by JSPS KAKENHI Grants JP18H01210, JP18K03651, and MEXT KAKENHI Grant JP18H05543. The work of K Sinha is supported in part by US DOE Grant DE-SC0009956. The work of T Sjöstrand is supported by the Swedish Research Council, Contract 2016-05996. J T Sobczyk acknowledges support from NCN Grant UMO-2021/41/B/ST2/02778. D Soldin acknowledges support from the US NSF Grant PHY-1913607. H Song is supported by the International Postdoctoral Exchange Fellowship Program. Y Soreq is supported by grants from the NSF-BSF, BSF, the ISF and by the Azrieli foundation. A Stasto acknowledges support from US DOE Grant DE-SC-0002145. S Su is supported by the US DOE Grant DE-FG02-13ER41976/DE-SC0009913. W Su is supported by a KIAS Individual Grant (PG084201) at Korea Institute for Advanced Study. Y Takubo is supported by JP20K04004. M Taoso acknowledges support from the INFN Grant 'LINDARK', the research grant 'The Dark Universe: A Synergic Multimessenger Approach 2017X7X85' funded by MIUR, and the project 'Theoretical Astroparticle Physics (TAsP)' funded by the INFN. The research activities of B Thomas are supported in part by US NSF Grant PHY-2014104. The work of Y-D Tsai is supported in part by US NSF Grant PHY-1915005. The work of A Sabio Vera has been supported by the Spanish Research Agency (Agencia Estatal de Investigación) through the Grant IFT Centro de Excelencia Severo Ochoa SEV-2016-0597, by the Spanish Government Grant FPA2016-78022-P and from the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement 824093. The work of Yongchao Zhang is supported by the National Natural Science Foundation of China Grant 12175039, the 2021 Jiangsu Shuangchuang (Mass Innovation and Entrepreneurship) Talent Program JSSCBS20210144, and the 'Fundamental Research Funds for the Central Universities'. Yue Zhang is supported by the Arthur B McDonald Canadian Astroparticle Physics Research Institute. R Zukanovich Funchal is partially supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and Conselho Nacional de Ciência e Tecnologia (CNPq). The opinions and conclusions expressed herein are those of the authors and do not represent any funding agencies., High energy collisions at the High-Luminosity Large Hadron Collider (LHC) produce a large number of particles along the beam collision axis, outside of the acceptance of existing LHC experiments. The proposed Forward Physics Facility (FPF), to be located several hundred meters from the ATLAS interaction point and shielded by concrete and rock, will host a suite of experiments to probe standard model (SM) processes and search for physics beyond the standard model (BSM). In this report, we review the status of the civil engineering plans and the experiments to explore the diverse physics signals that can be uniquely probed in the forward region. FPF experiments will be sensitive to a broad range of BSM physics through searches for new particle scattering or decay signatures and deviations from SM expectations in high statistics analyses with TeV neutrinos in this low-background environment. High statistics neutrino detection will also provide valuable data for fundamental topics in perturbative and non-perturbative QCD and in weak interactions. Experiments at the FPF will enable synergies between forward particle production at the LHC and astroparticle physics to be exploited. We report here on these physics topics, on infrastructure, detector, and simulation studies, and on future directions to realize the FPF's physics potential., German Research Foundation (DFG) SFB 876 SFB 1491, National Science Foundation (NSF) PHY2112527, Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research (KAKENHI) JP18H01210 JSPS KAKENHI JP20K23373 JP19H01909 JSPS KAKENHI JP19J13812 JP21K20365 JSPS KAKENHI JP18K03651, European Research Council (ERC) 101002690, National Research Foundation of Korea NRF-2020R1I1A3072747, Patrimonio Autónomo-Fondo Nacional de Financiamiento para la Ciencia Tecnología y la Innovación Francisco José de Caldas (MinCiencias-Colombia) 80740-465-2020, European Commission Joint Research Centre 860881-HIDDeN European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Grant 754446, United States Department of Energy (DOE) DE-SC0007914, Fermi National Accelerator Laboratory (Fermilab), a US DOE, Office of Science, HEP User Facility, Fermi Research Alliance, LLC (FRA) DE-AC02-07CH11359, German Research Foundation (DFG) HA 8555/1-1, DFG Collaborative Research Centre 'Neutrinos and Dark Matter in Astro-and Particle Physics' SFB 1258, Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) 2015/25884-4 2019/15149-6, United States Department of Energy (DOE) DE-SC0009920, Heising-Simons Foundation 2022-3319 2019-1179 2020-1840, ERC under the European Union's Horizon 2020 Research and Innovation Programme 694896 803183, UGR Research and Knowledge Transfer Found-Athenea3i, Ministry of Science and Innovation, Spain (MICINN) Spanish Government, SRA Grant PID2019-106087GB-C22, Junta de Andalucía A-FQM-472-UGR20, Fundacao para a Ciencia e a Tecnologia (FCT) CERN/FIS-PAR/0024/2019 03216/2017, United States Department of Energy (DOE) DE-SC0011702 DE-SC0017987 DE-FG02-13ER41976/DE-SC0009913 DE-SC0012704 DE-SC0010813 DE-AC02-76SF00515 DE-FG02-00ER41132 DE-AC-76SF00098 DE-SC0010504 DE-SC0022345 DE-SC0010129, US NSF through its employee IR/D program, National Key Research and Development Program of China 2020YFC2201501, National Natural Science Foundation of China (NSFC) 12022514 11875003 12047503, CAS Project for Young Scientists in Basic Research YSBR-006, Key Research Program of the CAS XDPB15, National Research Foundation of Korea (NRF)'s Grants 6N021413, Saramadan Contract ISEF/M/400279, National Science Foundation (NSF) PHY-1915005 PHY-2111427 PHY1430152 PHY-2014071 PHY-1307472 PHY-2014104, Simons Investigator Award 376204, Simons Foundation 623683, National Science Foundation (NSF) DGE-1839285, FAPESP Contract 2020/00174-2, UKRI Future Leaders Fellowship DARKMAP, Natural Sciences and Engineering Research Council of Canada (NSERC), German Research Foundation (DFG) EXC-2123 390837967, INFN/QFT@COLLIDERS project, European Union's H2020-MSCA Grant Agreement 101025085, Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), ANPCyT, Federal Ministry of Education & Research (BMBF) 05H21GUCCA, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ), Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Fundacao de Amparo a Ciencia e Tecnologia do Estado do Rio Grande do Sul (FAPERGS), INCT-FNA 464898/2014-5, J C Bose Fellowship of Science and Engineering Research Board of Department of Science and Technology, Government of India JCB/2020/000011, National Science Foundation (NSF) PHY-2112025, UK Research & Innovation (UKRI) Science & Technology Facilities Council (STFC) Science and Technology Development Fund (STDF) ST/L000377/1, Grant ANID FONDECYT-Chile 1201673, ANID-Millennium Science Initiative Program ICN2019-044, Spanish Grant (AEI) PID2020-113775GBI00, Center for Forestry Research & Experimentation (CIEF) PROMETEO/2018/165, National Science Centre, Poland 2018/31/D/ST2/00813, International Postdoctoral Exchange Fellowship Program, KIAS Individual Grant PG021403, National Research Foundation of Korea NRF-2019R1A2C3005009, Austrian Science Fund Elise-Richter Grant V592-N27, US NSF Theoretical Physics Program PHY-1915005, Samsung, National Natural Science Foundation of China (NSFC) 11905149, Polish National Science Centre 2018/31/B/ST2/03537, UK Research & Innovation (UKRI) Science & Technology Facilities Council (STFC) ST/P001246/1, Royal Society of London URF R1 201519, Netherlands Organization for Scientific Research (NWO) 680.92.18.03 Physics Vrij Programme .The Hidden Universe of Weakly Inter-acting Particles' - Dutch Research Council (NWO), UK Research & Innovation (UKRI) Science & Technology Facilities Council (STFC) ST/T000600/1 ST/P000630/1, Netherlands Organization for Scientific Research (NWO), European Union under the European Regional Development Fund, Polish Ministry of Science and Higher Education through its scholarship for young and outstanding scientists 1190/E-78/STYP/14/2019, European Commission 952480, ERC under the European Union 758316, Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) JP18H05543 MEXT KAKENHI, Swedish Research Council 2016-05996, NCN UMO-2021/41/B/ST2/02778, NSF-BSF, US-Israel Binational Science Foundation, Israel Science Foundation, Azrieli foundation, KIAS Individual Grant at Korea Institute for Advanced Study PG084201, Istituto Nazionale di Fisica Nucleare (INFN), Ministry of Education, Universities and Research (MIUR) 2017X7X85', Spanish Government SEV-2016-0597 Spanish Research Agency (Agencia Estatal de Investigacion) through the Grant IFT Centro de Excelencia Severo Ochoa FPA2016-78022-P, European Union's Horizon 2020 Research and Innovation Programme 824093, National Natural Science Foundation of China (NSFC) 12175039, 2021 Jiangsu Shuangchuang (Mass Innovation and Entrepreneurship) Talent Program JSSCBS20210144, Fundamental Research Funds for the Central Universities, Arthur B McDonald Canadian Astroparticle Physics Research Institute, Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), United States Department of Energy (DOE) DE-SC0012447 DE-SC0009824 DE-SC0013880 :The US DOE DE-SC-0010113 DOE DE-SC-0009913 US DOE DE-SC0009956 DE-FG02-13ER41976/DESC0009913 US DOE JP20K04004

Peter Wilson’s early work from the late 1970s is unusual for its focus on representations of the self. This evolved through a positioning of his work in relation to: his colleagues at the Architect...

The article is devoted to the study of the role of individual socialization and individual legal socialization in the formation anddevelopment of individual human habit in the conditions of local self-government.The author tries to prove that individual socialization and individual legal socialization play a fundamental role in the formationand development of individual human habit in terms of local self-government – that is, at the local level of society (spatial criterion) inthe territorial community (territorial community). in the conditions of everyday life (class criterion) where the human life cycle is actuallyrealized.It is proved that in the process of individual and, in general, collective socialization, their important parametric features are mani -fested, which concern: a) the social space where they take place; b) places where they occur; c) organizational and organizational andlegal conditions under which they occur; c) the state in which socialization processes take place; d) the functional for which the aboveprocesses of socialization take place; e) the basic foundations on which the above processes of socialization; f) the boundaries of thesystem of power, where the above processes of socialization; g) the circle of immanent partners of public power in the above processesof socialization; h) the final result of the above processes of socialization.It is argued that the consideration of the phenomenologies of general socialization and legal socialization in different qualitativestates and in the contextualization of the formation of human habit, allows us to assert the existence of a stable logical sequential systemicconnection between them.The author’s systematic analysis of the phenomenologies of general socialization and legal socialization in the contextualization andformation of human habit allows to build a procedural chain that clearly reflects the relationship of these phenomena with the conditionsof their formation and implementation – so, in his opinion, such a chain can be reflected : “Man” – “territorial community” – “local selfgovernment”– “state of everyday life” – “general individual (group, collective) socialization” – “legal socialization” – “human habit”.

COVID-19 has profoundly affected the American health care system; its effect on the liver transplant (LT) waitlist based on COVID-19 incidence has not been characterized. Using SRTR data, we compared observed LT waitlist registrations, waitlist mortality, deceased donor LTs (DDLT), and living donor LTs (LDLT) 3/15/2020-8/31/2020 to expected values based on historical trends 1/2016-1/2020, stratified by statewide COVID-19 incidence. Overall, from 3/15 to 4/30, new listings were 11% fewer than expected (IRR = 0.84 0.890.93 ), LDLTs were 49% fewer (IRR = 0.37 0.510.72 ), and DDLTs were 9% fewer (IRR = 0.85 0.910.97 ). In May, new listings were 21% fewer (IRR = 0.74 0.790.84 ), LDLTs were 42% fewer (IRR = 0.39 0.580.85 ) and DDLTs were 13% more (IRR = 1.07 1.151.23 ). Centers in states with the highest incidence 3/15-4/30 had 59% more waitlist deaths (IRR = 1.09 1.592.32 ) and 34% fewer DDLTs (IRR = 0.50 0.660.86 ). By August, waitlist outcomes were occurring at expected rates, except for DDLT (13% more across all incidences). While the early COVID-affected states endured major transplant practice changes, later in the pandemic the newly COVID-affected areas were not impacted to the same extent. These results speak to the adaptability of the transplant community in addressing the pandemic and applying new knowledge to patient care.

ImportanceFrailty has been recognized as a risk factor for mortality after liver transplant (LT) but little is known of its association with functional status and health-related quality of life (HRQL), termed global functional health, in LT recipients.ObjectiveTo evaluate the association between pre-LT and post-LT frailty with post-LT global functional health.Design, Setting, and ParticipantsThis prospective cohort study was conducted at 8 US LT centers and included adults who underwent LT from October 2016 to February 2020.ExposuresFrail was defined by a pre-LT Liver Frailty Index (LFI) score of 4.5 or greater.Main Outcomes and MeasuresGlobal functional health at 1 year after LT, assessed using surveys (Short Form-36 [SF-36; summarized by physical component scores (PFC) and mental component summary scores (MCS)], Instrumental Activities of Daily Living scale) and performance-based tests (LFI, Fried Frailty Phenotype, and Short Physical Performance Battery).ResultsOf 358 LT recipients (median [IQR] age, 60 [53-65] years; 115 women [32%]; 25 [7%] Asian/Pacific Islander, 21 [6%] Black, 54 [15%] Hispanic White, and 243 [68%] non-Hispanic White individuals), 68 (19%) had frailty pre-LT. At 1 year post-LT, the median (IQR) PCS was lower in recipients who had frailty vs those without frailty pre-LT (42 [31-53] vs 50 [38-56]; P = .002), but the median MCS was similar. In multivariable regression, pre-LT frailty was associated with a −5.3-unit lower post-LT PCS (P P P = .01).Conclusions and RelevanceIn this cohort study, pre-LT frailty was associated with worse global functional health 1 year after LT. The presence of frailty after LT was also associated with worse HRQL in physical, but not mental, subdomains. These data suggest that interventions and therapeutics that target frailty that are administered before and/or early post-LT may help to improve the health and well-being of LT recipients.

Mycophenolate is the mainstay of treatment for many organ and life-threatening manifestations of rheumatic and musculoskeletal diseases (RMD). In contrast to most patients with RMD, those taking mycophenolate have an attenuated humoral response to SARS-CoV-2 mRNA vaccination.1 2 The American College of Rheumatology recently recommended withholding mycophenolate for 1 week after vaccination to enhance immunogenicity in this vulnerable population.3 Thus, we sought to analyse the impact of withholding perivaccination mycophenolate in 24 patients with RMD. We leveraged our observational prospective cohort of patients with RMD without prior COVID-19 who underwent SARS-CoV-2 vaccination between 17 December 2020 and 13 May 2021.2 Information on demographics, diagnoses, immunosuppressive regimens and management of perivaccination immunosuppression was collected via electronic questionnaire. One month following vaccination, venipuncture samples were obtained and tested on the semiquantitative Roche Elecsys anti-SARS-CoV-2 S enzyme immunoassay which tests for antibodies against the receptor binding domain (RBD) of the SARS-CoV-2 spike protein; a consistent correlate of neutralising antibody.4 We compared the percentage of participants with detectable anti-RBD antibody in the group that withheld mycophenolate (n=24) to the group that continued mycophenolate (n=171) using Fisher’s exact test (online supplemental table 1). Crude and adjusted logistic regression analyses were performed to assess associations between antibody response and the primary variable of withholding mycophenolate, as well as after adjusting for clinical characteristics (age, sex, race, vaccine type (mRNA vs adenovirus vector), use of rituximab and glucocorticoids). Wilcoxon rank-sum test was used to compare anti-RBD titers of the …

The flux power spectrum of the high resolution Lyman-$\alpha$ forest data exhibits suppression at small scales. The origin of this suppression can be due to long-sought warm dark matter (WDM) or to thermal effects, related to the largely unknown reionization history of the Universe. Previous works explored a specific class of reionization histories that exhibit sufficiently strong thermal supression and leave little room for warm dark matter interpretation. In this work we choose a different class of reionization histories, fully compatible with available data on evolution of reionization, but much colder then the reionization histories used by previous authors in determining the nature of dark matter, thus leaving the broadest room for the WDM interpretation of the suppression in the flux power spectrum. We find that WDM thermal relics with masses below 1.9 keV (95% CL) would produce a suppression at scales that are larger than observed maximum of the flux power spectrum, independently of assumptions about thermal effects. This WDM mass is significantly lower than previously claimed bounds, demonstrating the level of systematic uncertainty of the Lyman-$\alpha$ forest method, due to the previous modelling. We also discuss how this uncertainty may affect also data at large scales measured by eBOSS., Comment: 8 pages, 6 figures

A wide gap between the increasing demand for organs and the limited supply leads to immeasurable loss of life each year. The organ shortage could be attenuated by donors with human immunodeficiency virus (HIV) or hepatitis C virus (HCV). The transplantation of organs from HIV+ deceased donors into HIV+ individuals (HIV D+ /R+) was initiated in South Africa in 2010; however, this practice was forbidden in the USA until the HIV Organ Policy Equity (HOPE) Act in 2013. HIV D+/R+ transplantation is now practiced in the USA as part of ongoing research studies, helping to reduce waiting times for all patients on the waitlist. The introduction of direct acting antivirals for HCV has revolutionized the utilization of donors with HCV for HCV-uninfected (HCV-) recipients. This is particularly relevant as the HCV donor pool has increased substantially in the context of the rise in deaths related to drug overdose from injection drug use. This article serves to review the current literature on using organs from donors with HIV or HCV.

It has been established that for extrapolation of the functional dependence of true stresses for tensile conditions of cylindrical samples of metal materials in the region of large deformations, a power dependence is better suited, where the approximation parameters are uniquely determined by the standard mechanical characteristics of materials. A method is proposed for calculating the ultimate deformations during stretching of a sample under the simultaneous action of hydrostatic pressure. It is shown that the calculation results are in satisfactory agreement with the known experimental data obtained by P. Bridgman and J. Bell.

The article examines the theoretical approaches to understanding the location and functioning of man in the local community asa member.It is proved that the urgency of this issue is determined by the fact that for the first time, at the constitutional level, the Ukrainianstate has recognized the existence of a system of local interests, produced by the territorial community – territorial community, concerningthe existential issues of its existence and functioning. territorial units of the state, which were legalized as issues of local importance.Thus, such interests of the community, according to the current constitutional guidelines, are solved, first, through the use of aspecific historical and universal social and legal institution – local self-government, which really gives the community and its membersopportunities for self-organization in such a community, self-identification and self-expression. within such a community, as well asinitiatives to implement the latter, again within such a community. In addition, it is argued that local self-government is exercised eitherdirectly by such a community (through the use of appropriate mechanisms of direct democracy) or by local governments formed by thecommunity itself in the process of democratic elections and appointments and acting on the principles of representative democracy. Atthe same time, territorial communities act as the primary subjects of local self-government, and therefore local self-government bodiesmust act on behalf of and in the interests of the respective communities.It is argued that the phenomenology of self-presentation of man (personality) in the territorial community has a solid integralphilosophicalbasis, a significant doctrinal-normative basis, reflects axiological guidelines of local government and parametric-teleologicalvalues of formation, functioning, development and development and high motivation of a man (personality) – a member of thecommunity, because it demonstrates its ability to build harmonious relationships with other members of local society in local governmentand its bodies by either leveling their individual guidelines in favor of local society, or by adjusting, synergizing, adaptation tocollective needs. In addition, it demonstrates that the self-presentation of a man (personality) actively forms and demonstrates its selfworth,ability to self-identification, self-organization, self-activity, self-government, as well as the ability to build a balance of intereststhrough human size and application of individual and collective interests (intersubjectivity).

The purpose of this article is to study topical issues of the emergence, formation and manifestation of the international componentin the activities of local self-government bodies of Ukraine.It has been proved that the international legal component of local self-government is based on multilateral and multi-level coope -ration of the member states of the international community, acquiring phenomenological properties, because: A) relies on the possibi -lities of the phenomenon of globalization, which manifests itself in it in all three of its currently defined forms – economic, politicaland legal; B) uses the powerful spatially unifying potential of legal globalization as a powerful systemic and complex megatrend thatencompasses not only peoples and states, but also unites them around common strategic, tactical, and what is especially important –existential and everyday patterns of organization and implementation of the international, state, regional, local (collective), group andindividual life – through their coordination, integration and unification, convergence (rapprochement of the legal systems of states),their adaptation, approximation, and the like; C) determines and contextualizes new forms of interstate and international cooperationaimed at: deeper interaction of its subjects; is a powerful factor that is permanent in time; and multivariate in forms; poly-level andpoly-object development, which is accompanied by new and still unknown phenomena and trends – that is, we can talk about qualitative-paradigmatic and discursive civilizational changes, accompanied and manifested by the emergence of corresponding patterns ofdeep interaction, and significantly affecting the path of existence and further development peoples and states.It is argued that under the international component in its content, it is necessary to understand such aspects of the activities oflocal self-government bodies that are actually not connected in their emergence with the issues of “internal”, intrastate activities of thesepublic authorities, although in a broad teleological sense, it is this “international component “is aimed at facilitating and improving theactivities of such bodies within the national state through the acquisition of foreign experience, participation in international commercialand foreign economic activity, the formation of a local system of international cooperation.It is argued that the definition of a number of provisions (factors) of methodological properties that demonstrate the principles ofthe international and international legal potential of local self-government, its bodies and subjects (historical, psychological, collaboration,intersubjective, functional-active, ideological, public-state factors).

Clinical decision-making in kidney transplant (KT) during the coronavirus disease 2019 (COVID-19) pandemic is understandably a conundrum: both candidates and recipients may face increased acquisition risks and case fatality rates (CFRs). Given our poor understanding of these risks, many centers have paused or reduced KT activity, yet data to inform such decisions are lacking. To quantify the benefit/harm of KT in this context, we conducted a simulation study of immediate-KT vs delay-until-after-pandemic for different patient phenotypes under a variety of potential COVID-19 scenarios. A calculator was implemented (http://www.transplantmodels.com/covid_sim), and machine learning approaches were used to evaluate the important aspects of our modeling. Characteristics of the pandemic (acquisition risk, CFR) and length of delay (length of pandemic, waitlist priority when modeling deceased donor KT) had greatest influence on benefit/harm. In most scenarios of COVID-19 dynamics and patient characteristics, immediate KT provided survival benefit; KT only began showing evidence of harm in scenarios where CFRs were substantially higher for KT recipients (eg, ≥50% fatality) than for waitlist registrants. Our simulations suggest that KT could be beneficial in many centers if local resources allow, and our calculator can help identify patients who would benefit most. Furthermore, as the pandemic evolves, our calculator can update these predictions.

ObjectiveTo evaluate the efficacy and the safety of transabdominal versus the transgluteal approach during extracorporeal shock wave lithotripsy (SWL) for distal ureteral calculi.Material and methodsRetrospective analysis of 146 patients with a single distal ureteric stone, who underwent SWL in supine position, was performed. Stone dimensions, density, and the skin to stone distance (SSD) were obtained from preoperative computer tomography. In 76 cases, the procedure was performed using a transabdominal approach (Group 1). In 67 cases, SWL was performed via transgluteal approach, with shockwave source being placed below the patient (Group2). Stone-free rate (SFR), need for stenting, auxiliary procedures and complications rate was assessed for each group.ResultsDemographic characteristics and stone features were similar in both groups. The mean stone size was 6.14 (3.4-11.2) mm in group 1 and 6.17 (3.1-15.8) mm in group 2. The skin to stone distance was 114.23 ± 26.83 mm and 103.84 ± 14.69 mm for Group 1 and Group 2 respectively (p=0.004). The SFR was 54% and 85% for transabdominal and transgluteal approaches, respectively. (p=0.0004). Ureteral stenting was performed in 16% of transabdominal and in 4% of transgluteal interventions (p=0.03). Auxiliary intervention was performed in 25% of group 1 patients and in 8% of group 2. The complication rate was 16% and 7% for transabdominal and transgluteal and approaches, respectively. No serious postoperative complications were observed.ConclusionSupine, transgluteal position SWL for the distal ureteral stone had a higher stone-free-rate, lower complications rate and lower need stenting for additional procedures.

Background Immunocompromised patients were excluded from the trials of SARS-CoV-2 vaccines. Boyarsky et al recently reported that, only 17% of transplant recipients who received a single dose of SARS-CoV-2 vaccine developed detectable anti-spike antibody (compared to 100% of the nonimmunocompromised subjects in the pivotal trials) and after 2 doses response increased to 54% in transplant recipients.1,2. Methods Retrospective chart review of 14 patients who were diagnosed with COVID-19 despite completion of vaccination series. Results Fourteen SOT recipients were diagnosed with COVID-19 a median of 23.5 days from completion of vaccination. One patient died, 2 remain hospitalized and 11 are recovered at home. Fifty percent of patients infected required hospitalization for treatment of disease. Conclusions With this report of 14 patients who developed COVID-19 infection after completion of vaccination, we believe there is sufficient evidence to issue warnings that immunoincompetent populations should continue to practice strict COVID-19 precautions postvaccination. Transplant centers should reinforce that guidance given to the general population may not be applicable to the transplant population. A centralized transplant registry of fully vaccinated solid organ transplant patients who develop COVID-19 infections is vital. Further studies are critically needed to optimize COVID-19 vaccination protocols in transplant recipients.

Organs from uncontrolled DCD donors (uDCDs) have expanded donation in Europe since the 1980s, but are seldom used in the United States. Cited barriers include lack of knowledge about the potential donor pool, lack of robust outcomes data, lack of standard donor eligibility criteria and preservation methods, and logistical and ethical challenges. To determine whether it would be appropriate to invest in addressing these barriers and building this practice, we sought to enumerate the potential pool of uDCD donors. Using data from the Nationwide Emergency Department Sample, the largest all-payer emergency department (ED) database, between 2013 and 2016, we identified patients who had refractory cardiac arrest in the ED. We excluded patients with contraindications to both deceased donation (including infection, malignancy, cardiopulmonary disease) and uDCD (including hemorrhage, major polytrauma, burns, and poisoning). We identified 9828 (range: 9454-10 202) potential uDCDs/y; average age was 32 years, and all were free of major comorbidity. Of these, 91.1% had traumatic deaths, with major causes including nonhead blunt injuries (43.2%) and head injuries (40.1%). In the current era, uDCD donors represent a significant potential source of unused organs. Efforts to address barriers to uDCD in the United States should be encouraged.

The article is devoted to the study of human participation as a member of the community in the existence and functioning of the territorial community. The article contains a description of the types of territorial communities, as well as their general features. The article defines the way a person functions as a member of the community in the territorial community. It is determined that the territorial communities of the primary level are those communities in which a person fully realizes his right to local self- government, including, first of all, the realization of their existential interests and other needs due to the implementation of human life cycle within the territorial community. , mainly in the ordinary implementation of statehood. It is noted that the activities of local councils and their executive bodies in the understanding of teleological guidelines are carried out on behalf of and in the interests of the respective territorial communities, so there is a clear methodological and procedural link that arises in the implementation of these rights and interests. This issue is quite relevant, because most local communities and their members focus and concretize their needs and interests through the formation of key issues of local importance, which is a fundamental object of the institution of local government and local government. It is determined that the possibilities of territorial communities to determine their own administrative structures are quite limited in Ukraine, they are quite exhaustively defined centrally – in the relevant Law of Ukraine "On Local Self-Government in Ukraine". In addition, the cities of Kyiv and Sevastopol have not yet established their own executive structures of local self-government, and their functions are entrusted to the relevant local state administrations. This significantly limits the implementation of the principle of organizational autonomy.

The article attempts to systematically analyze the additional protocols of the European (Framework) Convention on Transfrontier Co-operation between Territorial Communities or Authorities of 1980 in the context of its development. Peculiarities of their adoption and implementation of provisions in Ukraine are revealed. It is noted that differences between the Council of Europe and the EU in the Euroregional sphere have intensified, as the promotion of the concept of creating such structures in the Council of Europe on the basis of interstate agreements actually increases the legal status of interested administrative-territorial entities and fuels political ambitions of local elites. Therefore, at the initial stage, the Council's proposal to create a single pan-European document and thus prevent the "gap" of the European legal space in the field of Euroregional construction, did not find support from the EU. It is noted that the Council of Europe has developed a tool for cooperation at local level, similar to the organizational structure proposed in Regulation 1082/2006, namely the ETS. The basic documents on the regulation of cross- border regional associations were developed by the Council of Europe is noted. It is determined that international agreements contain a systemic block of basic international legal norms on cross-border cooperation; agreements ratified by Ukraine (except for Additional Protocol № 3) are very important for the conceptual development of not only the strategy of Ukrainian border cooperation, but also the concept of regional policy of Ukraine, which is objectively due to Ukraine's activity in European interregional cooperation and pan-European integration; The implementation of Ukraine’s pro- European efforts is directly related to the active participation of its state institutions and local self-government bodies, which represent their territorial communities, in cross- border cooperation.