1. The microbiological diagnosis of tuberculous meningitis: results of Haydarpasa-1 study
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Ebru Kurşun, Derya Ozturk-Engin, Branislava Savic, Rok Čivljak, Bojana Beović, Mehmet Parlak, Elif Sahin-Horasan, Oguz Karabay, Selma Alabay, Emine Parlak, Esmeray Mutlu Yilmaz, Ahmad Khalifa, Uner Kayabas, Saim Dayan, Hakan Erdem, Sukran Kose, V Kirova, Jean-Paul Stahl, Gonul Sengoz, Bruno Cacopardo, Canan Agalar, Arjan Harxhi, Gorana Cosic, Yves Hansmann, Catalina Luca, Alpaslan Alp, Aysegul Ulu-Kilic, Mehmet Bitirgen, Kadriye Kart Yaşar, Özcan Deveci, Isik Somuncu Johansen, Mustafa Namiduru, Katell Andre, I Masse-Chabredier, H. Cem Gul, Serkan Oncu, Mustafa Sunbul, Akram Al-Mahdawi, Ayhan Akbulut, Gulden Yilmaz, Serda Gulsun, Oral Oncul, S Chadapaud, Soline Simeon, Melanie Catroux, Oğuz Reşat Sipahi, Recep Tekin, Ayşe Seza Inal, Mucahit Yemisen, Filiz Pehlivanoglu, Olga Dulovic, Asuman Inan, B. Lakatos, Bahar Kandemir, Nazif Elaldi, Ghaydaa A. Shehata, Ahmet Karakaş, Alper Şener, Mihai Nechifor, Muge Ozguler, Alexandru Crisan, Nurgul Ceran, Çukurova Üniversitesi, OMÜ, Ege Üniversitesi, [Erdem, H. -- Oncul, O.] GATA Haydarpasa Training Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Ozturk-Engin, D. -- Inan, A. -- Ceran, N.] Haydarpasa Numune Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Elaldi, N.] Cumhuriyet Univ Sch Med, Dept Infect Dis & Clin Microbiol, Sivas, Turkey -- [Gulsun, S.] Diyarbakir Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Sengoz, G. -- Pehlivanoglu, F.] Haseki Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Crisan, A.] Victor Babes Univ Med & Pharm, Dept Infect Dis, Timisoara, Romania -- [Johansen, I. S.] Odense Univ Hosp, Dept Infect Dis Q, DK-5000 Odense, Denmark -- [Nechifor, M.] Gr T Popa Univ Med & Pharm, Dept Pharmacol, Iasi, Romania -- [Al-Mahdawi, A.] Baghdad Teaching Hosp, Dept Neurol, Baghdad, Iraq -- [Civljak, R.] Univ Zagreb Sch Med, Dr Fran Mihaljev Univ Hosp Infect Dis, Dept Infect Dis, Zagreb, Croatia -- [Ozguler, M. -- Akbulut, A.] Firat Univ Sch Med, Dept Infect Dis & Clin Microbiol, Elazig, Turkey -- [Savic, B.] Univ Belgrade, Inst Microbiol & Immunol, Natl Reference Lab TB, Fac Med, Belgrade, Serbia -- [Cacopardo, B.] Univ Catania, Infect Dis Sect, Dept Clin & Mol Biomed, Catania, Italy -- [Inal, A. S.] Cukurova Univ Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Namiduru, M.] Gaziantep Univ Sch Med, Dept Infect Dis & Clin Microbiol, Gaziantep, Turkey -- [Dayan, S. -- Tekin, R. -- Deveci, O.] Dicle Univ Sch Med, Dept Infect Dis & Clin Microbiol, Diyarbakir, Turkey -- [Kayabas, U.] Inonu Univ Sch Med, Dept Infect Dis & Clin Microbiol, Malatya, Turkey -- [Parlak, E. -- Parlak, M.] Ataturk Univ Sch Med, Dept Infect Dis & Clin Microbiol, Erzurum, Turkey -- [Khalifa, A.] Damascus Hosp, Dept Neurol, Damascus, Syria -- [Kursun, E.] Baskent Univ Sch Med, Dept Infect Dis & Clin Microbiol, Adana, Turkey -- [Sipahi, O. R.] Ege Univ Sch Med, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Yemisen, M.] Istanbul Univ Cerrahpasa Sch Med, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Bitirgen, M. -- Kandemir, B.] Necmettin Erbakan Univ Sch Med, Dept Infect Dis & Clin Microbiol, Konya, Turkey -- [Dulovic, O.] Univ Belgrade, Clin Infect & Trop Dis, Clin Ctr Serbia, Fac Med, Belgrade, Serbia -- [Luca, C.] Gr T Popa Univ Med & Pharm, Dept Infect Dis, Iasi, Romania -- [Stahl, J. P.] Joseph Fourier Univ & Univ Hosp Grenoble, Dept Infect Dis, Grenoble, France -- [Simeon, S.] Univ Hosp Pontchaillou, Dept Infect & Trop Dis, Rennes, France -- [Ulu-Kilic, A. -- Alabay, S.] Erciyes Univ Sch Med, Dept Infect Dis & Clin Microbiol, Kayseri, Turkey -- [Yasar, K.] Bakrkoy Dr Sadi Konuk Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey -- [Yilmaz, G.] Ankara Univ Sch Med, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Yilmaz, E.] Uludag Univ Sch Med, Dept Infect Dis & Clin Microbiol, Bursa, Turkey -- [Beovic, B.] Univ Med Ctr, Dept Infect Dis, Ljubljana, Slovenia -- [Catroux, M.] Univ Poitiers Hosp, Dept Infect Dis, Poitiers, France -- [Lakatos, B.] St Laszlo Hosp, Dept Infect Dis, Budapest, Hungary -- [Sunbul, M.] Ondokuz Mayis Univ Sch Med, Dept Infect Dis & Clin Microbiol, Samsun, Turkey -- [Sahin-Horasan, E.] Mersin Univ Sch Med, Dept Infect Dis & Clin Microbiol, Mersin, Turkey -- [Kose, S.] Tepecik Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Izmir, Turkey -- [Shehata, G.] Assiut Univ Hosp, Dept Neurol & Psychiat, Assiut, Egypt -- [Andre, K.] Dax Hosp, Dept Infect Dis, Dax, France -- [Alp, A.] Hacettepe Univ, Sch Med, Deparment Med Microbiol, Ankara, Turkey -- [Cosic, G.] Univ Novi Sad, Fac Med, Dept Prevent & Control Dis, IPH Vojvodina, Novi Sad, Serbia -- [Gul, H. Cem -- Karakas, A.] Gulhane Mil Med Acad, Dept Infect Dis & Clin Microbiol, Ankara, Turkey -- [Chadapaud, S.] Marie Jose Treffot Hosp, Dept Infect Dis, Hyeres, France -- [Hansmann, Y.] Univ Hosp, Dept Infect Dis, Strasbourg, France -- [Harxhi, A.] Univ Hosp Ctr Tirana, Infect Dis Serv, Tirana, Albania -- [Kirova, V.] Univ Clin Infect Dis & Febrile Condit, Skopje, Macedonia -- [Masse-Chabredier, I.] Aurillac Hosp, Dept Infect Dis, Aurillac, France -- [Oncu, S.] Adnan Menderes Univ Sch Med, Dept Infect Dis & Clin Microbiol, Aydin, Turkey -- [Sener, A.] Onsekiz Mart Univ Sch Med, Dept Infect Dis & Clin Microbiol, Canakkale, Turkey -- [Karabay, O.] Sakarya Univ Sch Med, Dept Infect Dis & Clin Microbiol, Sakarya, Turkey -- [Agalar, C.] Fatih Sultan Mehmet Training & Res Hosp, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey, Inal, Ayse Seza -- 0000-0002-1182-7164, Ghaydaa, Shehata -- 0000-0002-3631-893X, johansen, isik somuncu -- 0000-0002-2189-9823, Karabay, Oguz -- 0000-0003-0502-432X, Karakas, Ahmet -- 0000-0002-0553-8454, Kart Yasar, Kadriye -- 0000-0003-2963-4894, Stahl, Jean Paul -- 0000-0002-0086-3557, Elaldi, Nazif -- 0000-0002-9515-770X, ALP, ALPASLAN -- 0000-0001-7856-7590, and Civljak, Rok -- 0000-0001-8766-7438
- Subjects
Microbiology (medical) ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,QUANTIFERON-TB GOLD ,diagnosis ,Adenosine Deaminase ,Culture ,Tuberculous meningitis ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Internal medicine ,Diagnosis ,medicine ,Tuberculosis ,Humans ,Meningitis ,030212 general & internal medicine ,Precision Medicine ,Aged ,Retrospective Studies ,culture ,meningitis ,PCR ,tuberculosis ,Aged, 80 and over ,Bacteriological Techniques ,business.industry ,General Medicine ,Mycobacterium tuberculosis ,Middle Aged ,medicine.disease ,3. Good health ,Surgery ,Löwenstein–Jensen medium ,Infectious Diseases ,Early Diagnosis ,Tuberculosis, Meningeal ,Positive culture ,Female ,business ,030217 neurology & neurosurgery ,Interferon-gamma Release Tests - Abstract
WOS: 000345825900004, PubMed ID: 24849547, We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon- release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Lowenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p
- Published
- 2013