1. Protective Effect of Wheat Derived Non-specific lipid-transfer Protein 2 on Vascular Endothelium Inflammation
- Author
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Emanuela Leoncini, Cecilia Prata, Marco Malaguti, Cristina Angeloni, Luca Massaccesi, Sara Bosi, Valeria Bregola, Ilaria Marotti, Giovanni Dinelli, Silvana Hrelia, ANGELONI, CRISTINA, and Emanuela Leoncini, Cecilia Prata, Marco Malaguti, Cristina Angeloni, Luca Massaccesi, Sara Bosi, Valeria Bregola, Ilaria Marotti, Giovanni Dinelli, Silvana Hrelia
- Subjects
2. Zero hunger ,0301 basic medicine ,wheat, bioactive peptides, nsLTP2, vascular endothelium, cytoprotection, inflammation ,030109 nutrition & dietetics ,Endothelium ,Cell adhesion molecule ,business.industry ,medicine.medical_treatment ,Inflammation ,medicine.disease ,Cytoprotection ,Cell biology ,03 medical and health sciences ,chemistry.chemical_compound ,medicine.anatomical_structure ,Cytokine ,chemistry ,medicine ,medicine.symptom ,Endothelial dysfunction ,business ,Plant lipid transfer proteins ,Heme - Abstract
The important functions of the endothelium and the relationship between cardiovascular risk factors and endothelial dysfunction suggest the primary role of this tissue as a target for dietary strategies aimed at the prevention from related diseases. Cereals are key component of a healthy and balanced diet, and the presence of non-specific lipid-transfer protein 2 (nsLTP2) in wheat represents an added value to contribute to maintain the functionality of the vascular endothelium and consequently of the cardiovascular system. Indeed, nsLTP2 downregulates the expression of the main cell adhesion molecules induced by a pro-inflammatory cytokine and, meanwhile, upregulates heme oxigenase-1, exerting a cytoprotective/anti-inflammatory activity. Therefore, nsLTP2 might represent a food-derived tool to protect the vascular system against several pathological conditions.
- Published
- 2018