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BACKGROUND Cystic fibrosis (CF) is an autosomal recessively inherited disease. Clinical findings vary by age of the patient, the organ systems involved, and the severity of the CFTR gene mutation. Pancreatic and liver involvement is prominent and exocrine pancreatic insufficiency is observed in the majority of patients. Point shear wave elastography (pSWE) is a non-invasive method that can quantitatively determine tissue elasticity and stiffness. In this study, the morphological evaluation of the pancreas was performed using the pSWE technique in pediatric patients diagnosed with CF. The effectiveness of this method for early detection of pancreatic insufficiency was investigated. METHODS Fifty-five patients with CF (24 girls, 31 boys) and 60 healthy children (29 girls, 31 boys) without any chronic diseases and who were suitable for the pSWE examination were included in the study. RESULTS The mean value of pSWE was 1.12±0.16 in the healthy group and 0.97±0.16 in the patients with cystic fibrosis. There was a statistically significant difference between the two groups (p

Background: Acute kidney injury (AKI) common and important clinical challenge, and renal ischemia reperfusion (I/R) injury is the major reason of AKI. Renal I/R can lead to lung injury and increased mortality. Aims: This study was designed to evaluate whether paricalcitol may protect lung injury following renal I/R injury via its antioxidant properties. Methods: Rats (n=7 per group) were divided into four groups; control, paricalcitol, I/R, and paricalcitol+I/R. Rats were received daily intraperitoneal injection of paricalcitol (0.3 μg/kg) for 5 days in paricalcitol and paricalcitol+I/R groups. On day six, rats were subjected to I/R injury (60 minutes of left renal artery occlusion followed by 60 minutes of reperfusion) after right nephrectomy. Renal function tests, oxidant and antioxidant parameters, and lung histology of both groups were examined. Results: Rats treated with paricalcitol prior to ischemia reperfusion injury exhibited significant reduction in terms of serum and lung tissue malondialdehyde and totaloxidant status levels and significant increase in terms of serum and lung tissue nitric oxide and total antioxidant capacity levels levels (p Conclusions: Paricalcitol may ameliorate renal I/R induced lung injury by attenuating oxidative stress. Figure 1 Serum and lung tissue antioxidant parameters NO;nitric oxide TAC;total antioxidant capacity Pari;paricalcitol # p ## p