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2. Association between thiol-disulfide hemostasis and transient tachypnea of the newborn in late-preterm and term infants

Author

Mehmet Semih Demirtas, Huseyin Erdal, Fatih Kilicbay, and Gaffari Tunc

Subjects
Pediatrics, Perinatology and Child Health
Abstract

Background Transient tachypnea of the newborn (TTN), which is the most common respiratory disease in the neonatal period, increases respiratory workload in newborns. We purposed to evaluate the oxidative stress (OS) status and thiol disulfide hemostasis in late preterm and term newborns with TTN in this study. Methods The study was carried out in a single-centre neonatal intensive care unit to investigate the effect of continuous airway positive pressure (CPAP) on the oxidative system in newborns with TTN. Thiol (native and total) and disulfide levels, total antioxidant and oxidant status (TAS/TOS) and Oxidative stress index (OSI) levels were measured. Results Total thiol levels measured before treatment was 429.5 (369.5–487) µmol/L in the late preterm group and 425 (370–475) µmol/L in the term group (p = 0.741). We found significant changes in TOS, OSI and TAS levels after CPAP treatment in the late preterm group (p p p = 0.012 respectively). It was also found that the disulfide level, which was 26.2 (19.2–31.7) before the treatment, decreased to 19.5 (15.5–28.75) after the treatment (p = 0.001) in late preterms. Conclusion CPAP treatment reduced the OS status burden associated with TTN in neonates. The late preterm newborns with TTN are more affected by OS and increased OS levels decrease with CPAP treatment.

Published
2023
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4. Prolonged Tracheal Intubation and the Association Between Patent Ductus Arteriosus and Bronchopulmonary Dysplasia: A Secondary Analysis of the PDA-TOLERATE trial

Author

Ronald I. Clyman, Joseph Kaempf, Melissa Liebowitz, Omer Erdeve, Ali Bulbul, Stellan Håkansson, Johanna Lindqvist, Aijaz Farooqi, Anup Katheria, Jason Sauberan, Jaideep Singh, Kelly Nelson, Andrea Wickremasinghe, Lawrence Dong, Denise C. Hassinger, Susan W. Aucott, Madoka Hayashi, Anne Marie Heuchan, William A. Carey, Matthew Derrick, Erika Fernandez, Meera Sankar, Tina Leone, Jorge Perez, Arturo Serize, Scott Fields, Lora Whitten, Stefanie Rogers, Emel Okulu, Gaffari Tunc, Tayfun Ucar, Ebru Türkoglu Ünal, Jane Steen, Kathy Arnell, Sarah Holtschlag, Michael Schreiber, Caryn Peters, Maureen Gilmore, Lorna McKay, Dianne Carole, Annette Shaw, Malinda Harris, Amy Amsbaugh, Lavonne M. Liedl, Sue Wolf, Avi Groner, Amy Kimball, Jae Kim, Renee Bridge, Ellen Knodel, Chrissy Weng, Magaly Diaz Barbosa, Richard Polin, Marilyn Weindler, Shahab Noori, Jeffrey Reese, and Yao Sun

Subjects
Male, Time Factors, health care facilities, manpower, and services, medicine.medical_treatment, Cardiovascular, Low Birth Weight and Health of the Newborn, Severity of Illness Index, Pediatrics, 0302 clinical medicine, Ductus arteriosus, Secondary analysis, Infant Mortality, Prospective Studies, 030212 general & internal medicine, Ductus Arteriosus, Patent, Lung, Bronchopulmonary Dysplasia, Pediatric, Respiration, premature birth, medicine.anatomical_structure, Premature birth, Anesthesia, Artificial, Patent, Female, congenital, hereditary, and neonatal diseases and abnormalities, education, PDA-TOLERATE Trial Investigators, Neonatal Respiratory Distress, Paediatrics and Reproductive Medicine, patent ductus arteriosus, 03 medical and health sciences, Preterm, health services administration, 030225 pediatrics, bronchopulmonary dysplasia, Intubation, Intratracheal, medicine, Humans, cardiovascular diseases, business.industry, Prevention, Tracheal intubation, Infant, Newborn, Infant, Ductus Arteriosus, Human Movement and Sports Sciences, Perinatal Period - Conditions Originating in Perinatal Period, Newborn, medicine.disease, Respiration, Artificial, Intratracheal, Good Health and Well Being, Increased risk, Bronchopulmonary dysplasia, Pediatrics, Perinatology and Child Health, Intubation, business
Abstract

In the PDA-TOLERATE trial, persistent (even for several weeks) moderate to large patent ductus arteriosus (PDA) was not associated with an increased risk of BPD when the infant required

Published
2021
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5. PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-to-Large Patent Ductus Arteriosus at 1 Week of Age

Author

Ronald I. Clyman, Melissa Liebowitz, Joseph Kaempf, Omer Erdeve, Ali Bulbul, Stellan Håkansson, Johanna Lindqvist, Aijaz Farooqi, Anup Katheria, Jason Sauberan, Jaideep Singh, Kelly Nelson, Andrea Wickremasinghe, Lawrence Dong, Denise C. Hassinger, Susan W. Aucott, Madoka Hayashi, Anne Marie Heuchan, William A. Carey, Matthew Derrick, Erika Fernandez, Meera Sankar, Tina Leone, Jorge Perez, Arturo Serize, Scott Fields, Lora Whitten, Stefanie Rogers, Emel Okulu, Gaffari Tunc, Tayfun Ucar, Ebru Türkoglu Ünal, Jane Steen, Kathy Arnell, Sarah Holtschlag, Michael Schreiber, Caryn Peters, Maureen Gilmore, Lorna McKay, Dianne Carole, Annette Shaw, Malinda Harris, Amy Amsbaugh, Lavonne M. Liedl, Sue Wolf, Avi Groner, Amy Kimball, Jae Kim, Renee Bridge, Ellen Knodel, Chrissy Weng, Magaly Diaz Barbosa, Richard Polin, Marilyn Weindler, Shahab Noori, Jeffrey Reese, and Yao Sun

Subjects
Male, medicine.medical_treatment, Indomethacin, Ibuprofen, Reproductive health and childbirth, Conservative Treatment, Low Birth Weight and Health of the Newborn, Pediatrics, law.invention, Randomized controlled trial, law, newborn, Ductus arteriosus, Infant Mortality, Medicine, retinopathy of prematurity, Single-Blind Method, Continuous positive airway pressure, Prospective Studies, Ductus Arteriosus, Patent, Lung, Pediatric, Continuous Positive Airway Pressure, Gestational age, Retinopathy of prematurity, Hematology, premature birth, medicine.anatomical_structure, Treatment Outcome, Premature birth, Anesthesia, Infant, Extremely Premature, Necrotizing enterocolitis, Patent, Female, congenital, hereditary, and neonatal diseases and abnormalities, Clinical Trials and Supportive Activities, Gestational Age, Extremely Premature, TO LEave it alone or Respond And Treat Early) Trial Investigators [PDA-TOLERATE (PDA], Paediatrics and Reproductive Medicine, Clinical Research, Preterm, bronchopulmonary dysplasia, Humans, Cyclooxygenase Inhibitors, Acetaminophen, necrotizing enterocolitis, business.industry, Infant, Newborn, nutritional and metabolic diseases, Infant, Ductus Arteriosus, Human Movement and Sports Sciences, Perinatal Period - Conditions Originating in Perinatal Period, medicine.disease, Good Health and Well Being, Bronchopulmonary dysplasia, Pediatrics, Perinatology and Child Health, business, Digestive Diseases
Abstract

ObjectiveTo compare early routine pharmacologic treatment of moderate-to-large patent ductus arteriosus (PDA) at the end of week 1 with a conservative approach that requires prespecified respiratory and hemodynamic criteria before treatment can be given.Study designA total of 202 neonates of

Published
2019

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