43 results on '"Gladman, Dafna D"'
Search Results
2. Additional file 1 of Efficacy and safety of guselkumab in biologic-naïve patients with active axial psoriatic arthritis: study protocol for STAR, a phase 4, randomized, double-blinded, placebo-controlled trial
- Author
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Gladman, Dafna D., Mease, Philip J., Bird, Paul, Soriano, Enrique R., Chakravarty, Soumya D., Shawi, May, Xu, Stephen, Quinn, Sean T., Gong, Cinty, Leibowitz, Evan, Poddubnyy, Denis, Tam, Lai-Shan, Helliwell, Philip S., Kavanaugh, Arthur, Deodhar, Atul, Østergaard, Mikkel, and Baraliakos, Xenofon
- Abstract
Additional file 1. STAR Trial Registration Data.
- Published
- 2022
- Full Text
- View/download PDF
3. Additional file 2 of Efficacy and safety of guselkumab in biologic-naïve patients with active axial psoriatic arthritis: study protocol for STAR, a phase 4, randomized, double-blinded, placebo-controlled trial
- Author
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Gladman, Dafna D., Mease, Philip J., Bird, Paul, Soriano, Enrique R., Chakravarty, Soumya D., Shawi, May, Xu, Stephen, Quinn, Sean T., Gong, Cinty, Leibowitz, Evan, Poddubnyy, Denis, Tam, Lai-Shan, Helliwell, Philip S., Kavanaugh, Arthur, Deodhar, Atul, Østergaard, Mikkel, and Baraliakos, Xenofon
- Abstract
Additional file 2. STAR Trial SPIRIT Checklist.
- Published
- 2022
- Full Text
- View/download PDF
4. sj-docx-1-tab-10.1177_1759720X211057975 ��� Supplemental material for Axial Involvement in Psoriatic Arthritis cohort (AXIS): the protocol of a joint project of the Assessment of SpondyloArthritis international Society (ASAS) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)
- Author
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Poddubnyy, Denis, Baraliakos, Xenofon, Van den Bosch, Filip, Braun, J��rgen, Coates, Laura C., Chandran, Vinod, Diekhoff, Torsten, van Gaalen, Floris A., Gensler, Lianne S., Goel, Niti, Gottlieb, Alice B., van der Heijde, D��sir��e, Helliwell, Philip S., Hermann, Kay Geert A., Jadon, Deepak, Lambert, Robert G., Maksymowych, Walter P., Mease, Philip, Nash, Peter, Proft, Fabian, Protopopov, Mikhail, Sieper, Joachim, Torgutalp, Murat, and Gladman, Dafna D.
- Subjects
FOS: Clinical medicine ,110604 Sports Medicine ,FOS: Health sciences ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110314 Orthopaedics - Abstract
Supplemental material, sj-docx-1-tab-10.1177_1759720X211057975 for Axial Involvement in Psoriatic Arthritis cohort (AXIS): the protocol of a joint project of the Assessment of SpondyloArthritis international Society (ASAS) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) by Denis Poddubnyy, Xenofon Baraliakos, Filip Van den Bosch, J��rgen Braun, Laura C. Coates, Vinod Chandran, Torsten Diekhoff, Floris A. van Gaalen, Lianne S. Gensler, Niti Goel, Alice B. Gottlieb, D��sir��e van der Heijde, Philip S. Helliwell, Kay Geert A. Hermann, Deepak Jadon, Robert G. Lambert, Walter P. Maksymowych, Philip Mease, Peter Nash, Fabian Proft, Mikhail Protopopov, Joachim Sieper, Murat Torgutalp and Dafna D. Gladman in Therapeutic Advances in Musculoskeletal Disease
- Published
- 2021
- Full Text
- View/download PDF
5. sj-docx-2-tab-10.1177_1759720X211057975 ��� Supplemental material for Axial Involvement in Psoriatic Arthritis cohort (AXIS): the protocol of a joint project of the Assessment of SpondyloArthritis international Society (ASAS) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)
- Author
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Poddubnyy, Denis, Baraliakos, Xenofon, Van den Bosch, Filip, Braun, J��rgen, Coates, Laura C., Chandran, Vinod, Diekhoff, Torsten, van Gaalen, Floris A., Gensler, Lianne S., Goel, Niti, Gottlieb, Alice B., van der Heijde, D��sir��e, Helliwell, Philip S., Hermann, Kay Geert A., Jadon, Deepak, Lambert, Robert G., Maksymowych, Walter P., Mease, Philip, Nash, Peter, Proft, Fabian, Protopopov, Mikhail, Sieper, Joachim, Torgutalp, Murat, and Gladman, Dafna D.
- Subjects
FOS: Clinical medicine ,110604 Sports Medicine ,FOS: Health sciences ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110314 Orthopaedics - Abstract
Supplemental material, sj-docx-2-tab-10.1177_1759720X211057975 for Axial Involvement in Psoriatic Arthritis cohort (AXIS): the protocol of a joint project of the Assessment of SpondyloArthritis international Society (ASAS) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) by Denis Poddubnyy, Xenofon Baraliakos, Filip Van den Bosch, J��rgen Braun, Laura C. Coates, Vinod Chandran, Torsten Diekhoff, Floris A. van Gaalen, Lianne S. Gensler, Niti Goel, Alice B. Gottlieb, D��sir��e van der Heijde, Philip S. Helliwell, Kay Geert A. Hermann, Deepak Jadon, Robert G. Lambert, Walter P. Maksymowych, Philip Mease, Peter Nash, Fabian Proft, Mikhail Protopopov, Joachim Sieper, Murat Torgutalp and Dafna D. Gladman in Therapeutic Advances in Musculoskeletal Disease
- Published
- 2021
- Full Text
- View/download PDF
6. Table S1 - Supplemental material for Assessment of the Toronto Psoriatic Arthritis Screen 2 as a Screening Tool for Psoriasis
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Taylor, Jennifer H., Deo, Maneka, Sutton, Mitchell, Chandran, Vinod, Shanmugarajah, Sutha, Pereira, Daniel, Gladman, Dafna D., and Rosen, Cheryl F.
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Medicine - Abstract
Supplemental material, Table S1, for Assessment of the Toronto Psoriatic Arthritis Screen 2 as a Screening Tool for Psoriasis by Jennifer H. Taylor, Maneka Deo, Mitchell Sutton, Vinod Chandran, Sutha Shanmugarajah, Daniel Pereira, Dafna D. Gladman and Cheryl F. Rosen in Journal of Cutaneous Medicine & Surgery
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- 2021
- Full Text
- View/download PDF
7. Additional file 1 of Relationships between psoriatic arthritis composite measures of disease activity with patient-reported outcomes in phase 3 studies of tofacitinib
- Author
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Coates, Laura C., Bushmakin, Andrew G., FitzGerald, Oliver, Gladman, Dafna D., Fallon, Lara, Cappelleri, Joseph C., Ming-Ann Hsu, and Helliwell, Philip S.
- Abstract
Additional file 1 : Table S1. PROs included in the analysis. Table listing PROs and their descriptions included in the analysis of ScoreMDA and PASDAS.
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- 2021
- Full Text
- View/download PDF
8. Supplementary Material 1 - Supplemental material for Assessment of the Toronto Psoriatic Arthritis Screen 2 as a Screening Tool for Psoriasis
- Author
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Taylor, Jennifer H., Deo, Maneka, Sutton, Mitchell, Chandran, Vinod, Shanmugarajah, Sutha, Pereira, Daniel, Gladman, Dafna D., and Rosen, Cheryl F.
- Subjects
Medicine - Abstract
Supplemental material, Supplementary Material 1, for Assessment of the Toronto Psoriatic Arthritis Screen 2 as a Screening Tool for Psoriasis by Jennifer H. Taylor, Maneka Deo, Mitchell Sutton, Vinod Chandran, Sutha Shanmugarajah, Daniel Pereira, Dafna D. Gladman and Cheryl F. Rosen in Journal of Cutaneous Medicine & Surgery
- Published
- 2021
- Full Text
- View/download PDF
9. sj-docx-2-tab-10.1177_1759720X211057975 ��� Supplemental material for Axial Involvement in Psoriatic Arthritis cohort (AXIS): the protocol of a joint project of the Assessment of SpondyloArthritis international Society (ASAS) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)
- Author
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Poddubnyy, Denis, Baraliakos, Xenofon, Van den Bosch, Filip, Braun, J��rgen, Coates, Laura C., Chandran, Vinod, Diekhoff, Torsten, van Gaalen, Floris A., Gensler, Lianne S., Goel, Niti, Gottlieb, Alice B., van der Heijde, D��sir��e, Helliwell, Philip S., Hermann, Kay Geert A., Jadon, Deepak, Lambert, Robert G., Maksymowych, Walter P., Mease, Philip, Nash, Peter, Proft, Fabian, Protopopov, Mikhail, Sieper, Joachim, Torgutalp, Murat, and Gladman, Dafna D.
- Subjects
FOS: Clinical medicine ,110604 Sports Medicine ,FOS: Health sciences ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110314 Orthopaedics - Abstract
Supplemental material, sj-docx-2-tab-10.1177_1759720X211057975 for Axial Involvement in Psoriatic Arthritis cohort (AXIS): the protocol of a joint project of the Assessment of SpondyloArthritis international Society (ASAS) and the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) by Denis Poddubnyy, Xenofon Baraliakos, Filip Van den Bosch, J��rgen Braun, Laura C. Coates, Vinod Chandran, Torsten Diekhoff, Floris A. van Gaalen, Lianne S. Gensler, Niti Goel, Alice B. Gottlieb, D��sir��e van der Heijde, Philip S. Helliwell, Kay Geert A. Hermann, Deepak Jadon, Robert G. Lambert, Walter P. Maksymowych, Philip Mease, Peter Nash, Fabian Proft, Mikhail Protopopov, Joachim Sieper, Murat Torgutalp and Dafna D. Gladman in Therapeutic Advances in Musculoskeletal Disease
- Published
- 2021
- Full Text
- View/download PDF
10. Supplemental Material, PsAID12_Supplement - Evidence for Psoriatic Arthritis Impact of Disease (PsAID12) as Core Instrument to Measure Health-Related Quality of Life in Psoriatic Arthritis: A Systematic Review of Psychometric Properties
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Holland, Richard, Højgaard, Pil, Tillett, William, Gossec, Laure, Wit, Maarten De, Christensen, Robin, McHugh, Neil, Gladman, Dafna D., Mease, Philip, FitzGerald, Oliver, Shea, Beverly, Tugwell, Peter, Beaton, Dorcas, and Ana-Maria Orbai
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Medicine ,humanities - Abstract
Supplemental Material, PsAID12_Supplement for Evidence for Psoriatic Arthritis Impact of Disease (PsAID12) as Core Instrument to Measure Health-Related Quality of Life in Psoriatic Arthritis: A Systematic Review of Psychometric Properties by Richard Holland, Pil Højgaard, William Tillett, Laure Gossec, Maarten de Wit, Robin Christensen, Neil McHugh, Dafna D. Gladman, Philip Mease, Oliver FitzGerald, Beverly Shea, Peter Tugwell, Dorcas Beaton, Ana-Maria Orbai and GRAPPA-OMERACT PsA Working Group in Journal of Psoriasis and Psoriatic Arthritis
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- 2019
- Full Text
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11. Supplemental Material, Appendix_4_Study_Selection_Process - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
- Author
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Singh, Jasvinder A., Guyatt, Gordon, Ogdie, Alexis, Gladman, Dafna D., Deal, Chad, Deodhar, Atul, Dubreuil, Maureen, Dunham, Jonathan, M. Elaine Husni, Kenny, Sarah, Kwan-Morley, Jennifer, Lin, Janice, Marchetta, Paula, Mease, Philip J., Merola, Joseph F., Miner, Julie, Ritchlin, Christopher T., Siaton, Bernadette, Smith, Benjamin J., Voorhees, Abby S. Van, Jonsson, Anna Helena, Shah, Amit Aakash, Sullivan, Nancy, Turgunbaev, Marat, Coates, Laura C., Gottlieb, Alice, Magrey, Marina, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Scher, Jose U., Siegel, Evan, Siegel, Michael, Walsh, Jessica A., Turner, Amy S., and Reston, James
- Subjects
Medicine - Abstract
Supplemental Material, Appendix_4_Study_Selection_Process for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
- Published
- 2018
- Full Text
- View/download PDF
12. Supplemental Material, Singh_ART40726_Supplementary_Appendix_1_Methods - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
- Author
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Singh, Jasvinder A., Guyatt, Gordon, Ogdie, Alexis, Gladman, Dafna D., Deal, Chad, Deodhar, Atul, Dubreuil, Maureen, Dunham, Jonathan, M. Elaine Husni, Kenny, Sarah, Kwan-Morley, Jennifer, Lin, Janice, Marchetta, Paula, Mease, Philip J., Merola, Joseph F., Miner, Julie, Ritchlin, Christopher T., Siaton, Bernadette, Smith, Benjamin J., Voorhees, Abby S. Van, Jonsson, Anna Helena, Shah, Amit Aakash, Sullivan, Nancy, Turgunbaev, Marat, Coates, Laura C., Gottlieb, Alice, Magrey, Marina, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Scher, Jose U., Siegel, Evan, Siegel, Michael, Walsh, Jessica A., Turner, Amy S., and Reston, James
- Subjects
Medicine - Abstract
Supplemental Material, Singh_ART40726_Supplementary_Appendix_1_Methods for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
- Published
- 2018
- Full Text
- View/download PDF
13. Supplemental Material, Appendixs5_revised - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
- Author
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Singh, Jasvinder A., Guyatt, Gordon, Ogdie, Alexis, Gladman, Dafna D., Deal, Chad, Deodhar, Atul, Dubreuil, Maureen, Dunham, Jonathan, M. Elaine Husni, Kenny, Sarah, Kwan-Morley, Jennifer, Lin, Janice, Marchetta, Paula, Mease, Philip J., Merola, Joseph F., Miner, Julie, Ritchlin, Christopher T., Siaton, Bernadette, Smith, Benjamin J., Voorhees, Abby S. Van, Jonsson, Anna Helena, Shah, Amit Aakash, Sullivan, Nancy, Turgunbaev, Marat, Coates, Laura C., Gottlieb, Alice, Magrey, Marina, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Scher, Jose U., Siegel, Evan, Siegel, Michael, Walsh, Jessica A., Turner, Amy S., and Reston, James
- Subjects
Medicine - Abstract
Supplemental Material, Appendixs5_revised for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
- Published
- 2018
- Full Text
- View/download PDF
14. Supplemental Material, Appendix_2_Panel,_Teams_Involved - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
- Author
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Singh, Jasvinder A., Guyatt, Gordon, Ogdie, Alexis, Gladman, Dafna D., Deal, Chad, Deodhar, Atul, Dubreuil, Maureen, Dunham, Jonathan, M. Elaine Husni, Kenny, Sarah, Kwan-Morley, Jennifer, Lin, Janice, Marchetta, Paula, Mease, Philip J., Merola, Joseph F., Miner, Julie, Ritchlin, Christopher T., Siaton, Bernadette, Smith, Benjamin J., Voorhees, Abby S. Van, Jonsson, Anna Helena, Shah, Amit Aakash, Sullivan, Nancy, Turgunbaev, Marat, Coates, Laura C., Gottlieb, Alice, Magrey, Marina, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Scher, Jose U., Siegel, Evan, Siegel, Michael, Walsh, Jessica A., Turner, Amy S., and Reston, James
- Subjects
Medicine - Abstract
Supplemental Material, Appendix_2_Panel,_Teams_Involved for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
- Published
- 2018
- Full Text
- View/download PDF
15. Supplemental Material, Appendix_6_Strong_Recommendations.docx - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
- Author
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Singh, Jasvinder A., Guyatt, Gordon, Ogdie, Alexis, Gladman, Dafna D., Deal, Chad, Deodhar, Atul, Dubreuil, Maureen, Dunham, Jonathan, M. Elaine Husni, Kenny, Sarah, Kwan-Morley, Jennifer, Lin, Janice, Marchetta, Paula, Mease, Philip J., Merola, Joseph F., Miner, Julie, Ritchlin, Christopher T., Siaton, Bernadette, Smith, Benjamin J., Voorhees, Abby S. Van, Jonsson, Anna Helena, Shah, Amit Aakash, Sullivan, Nancy, Turgunbaev, Marat, Coates, Laura C., Gottlieb, Alice, Magrey, Marina, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Scher, Jose U., Siegel, Evan, Siegel, Michael, Walsh, Jessica A., Turner, Amy S., and Reston, James
- Subjects
Medicine - Abstract
Supplemental Material, Appendix_6_Strong_Recommendations.docx for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
- Published
- 2018
- Full Text
- View/download PDF
16. Supplemental Material, Appendix_1_Methods - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
- Author
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Singh, Jasvinder A., Guyatt, Gordon, Ogdie, Alexis, Gladman, Dafna D., Deal, Chad, Deodhar, Atul, Dubreuil, Maureen, Dunham, Jonathan, M. Elaine Husni, Kenny, Sarah, Kwan-Morley, Jennifer, Lin, Janice, Marchetta, Paula, Mease, Philip J., Merola, Joseph F., Miner, Julie, Ritchlin, Christopher T., Siaton, Bernadette, Smith, Benjamin J., Voorhees, Abby S. Van, Jonsson, Anna Helena, Shah, Amit Aakash, Sullivan, Nancy, Turgunbaev, Marat, Coates, Laura C., Gottlieb, Alice, Magrey, Marina, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Scher, Jose U., Siegel, Evan, Siegel, Michael, Walsh, Jessica A., Turner, Amy S., and Reston, James
- Subjects
Medicine - Abstract
Supplemental Material, Appendix_1_Methods for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
- Published
- 2018
- Full Text
- View/download PDF
17. Supplemental Material, Singh_ART40726_Supplementary_Appendix_4_Study_Selection_Process - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
- Author
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Singh, Jasvinder A., Guyatt, Gordon, Ogdie, Alexis, Gladman, Dafna D., Deal, Chad, Deodhar, Atul, Dubreuil, Maureen, Dunham, Jonathan, M. Elaine Husni, Kenny, Sarah, Kwan-Morley, Jennifer, Lin, Janice, Marchetta, Paula, Mease, Philip J., Merola, Joseph F., Miner, Julie, Ritchlin, Christopher T., Siaton, Bernadette, Smith, Benjamin J., Voorhees, Abby S. Van, Jonsson, Anna Helena, Shah, Amit Aakash, Sullivan, Nancy, Turgunbaev, Marat, Coates, Laura C., Gottlieb, Alice, Magrey, Marina, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Scher, Jose U., Siegel, Evan, Siegel, Michael, Walsh, Jessica A., Turner, Amy S., and Reston, James
- Subjects
Medicine - Abstract
Supplemental Material, Singh_ART40726_Supplementary_Appendix_4_Study_Selection_Process for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
- Published
- 2018
- Full Text
- View/download PDF
18. Supplemental Material, Appendix_3_PsA_Search_Strategies - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
- Author
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Singh, Jasvinder A., Guyatt, Gordon, Ogdie, Alexis, Gladman, Dafna D., Deal, Chad, Deodhar, Atul, Dubreuil, Maureen, Dunham, Jonathan, M. Elaine Husni, Kenny, Sarah, Kwan-Morley, Jennifer, Lin, Janice, Marchetta, Paula, Mease, Philip J., Merola, Joseph F., Miner, Julie, Ritchlin, Christopher T., Siaton, Bernadette, Smith, Benjamin J., Voorhees, Abby S. Van, Jonsson, Anna Helena, Shah, Amit Aakash, Sullivan, Nancy, Turgunbaev, Marat, Coates, Laura C., Gottlieb, Alice, Magrey, Marina, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Scher, Jose U., Siegel, Evan, Siegel, Michael, Walsh, Jessica A., Turner, Amy S., and Reston, James
- Subjects
Medicine - Abstract
Supplemental Material, Appendix_3_PsA_Search_Strategies for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
- Published
- 2018
- Full Text
- View/download PDF
19. Supplemental Material, Singh_ART40726_Supplementary_Appendix_2_Panel,_Teams_Involved - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
- Author
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Singh, Jasvinder A., Guyatt, Gordon, Ogdie, Alexis, Gladman, Dafna D., Deal, Chad, Deodhar, Atul, Dubreuil, Maureen, Dunham, Jonathan, M. Elaine Husni, Kenny, Sarah, Kwan-Morley, Jennifer, Lin, Janice, Marchetta, Paula, Mease, Philip J., Merola, Joseph F., Miner, Julie, Ritchlin, Christopher T., Siaton, Bernadette, Smith, Benjamin J., Voorhees, Abby S. Van, Jonsson, Anna Helena, Shah, Amit Aakash, Sullivan, Nancy, Turgunbaev, Marat, Coates, Laura C., Gottlieb, Alice, Magrey, Marina, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Scher, Jose U., Siegel, Evan, Siegel, Michael, Walsh, Jessica A., Turner, Amy S., and Reston, James
- Subjects
Medicine - Abstract
Supplemental Material, Singh_ART40726_Supplementary_Appendix_2_Panel,_Teams_Involved for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
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- 2018
- Full Text
- View/download PDF
20. Supplemental Material, Singh_ART40726_Supplementary_Appendix_3_PsA_Search_Strategies - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
- Author
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Singh, Jasvinder A., Guyatt, Gordon, Ogdie, Alexis, Gladman, Dafna D., Deal, Chad, Deodhar, Atul, Dubreuil, Maureen, Dunham, Jonathan, M. Elaine Husni, Kenny, Sarah, Kwan-Morley, Jennifer, Lin, Janice, Marchetta, Paula, Mease, Philip J., Merola, Joseph F., Miner, Julie, Ritchlin, Christopher T., Siaton, Bernadette, Smith, Benjamin J., Voorhees, Abby S. Van, Jonsson, Anna Helena, Shah, Amit Aakash, Sullivan, Nancy, Turgunbaev, Marat, Coates, Laura C., Gottlieb, Alice, Magrey, Marina, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Scher, Jose U., Siegel, Evan, Siegel, Michael, Walsh, Jessica A., Turner, Amy S., and Reston, James
- Subjects
Medicine - Abstract
Supplemental Material, Singh_ART40726_Supplementary_Appendix_3_PsA_Search_Strategies for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
- Published
- 2018
- Full Text
- View/download PDF
21. Supplemental Material, Singh_ART40726_Supplementary_Appendix_5_Evidence_Report - 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis
- Author
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Singh, Jasvinder A., Guyatt, Gordon, Ogdie, Alexis, Gladman, Dafna D., Deal, Chad, Deodhar, Atul, Dubreuil, Maureen, Dunham, Jonathan, M. Elaine Husni, Kenny, Sarah, Kwan-Morley, Jennifer, Lin, Janice, Marchetta, Paula, Mease, Philip J., Merola, Joseph F., Miner, Julie, Ritchlin, Christopher T., Siaton, Bernadette, Smith, Benjamin J., Voorhees, Abby S. Van, Jonsson, Anna Helena, Shah, Amit Aakash, Sullivan, Nancy, Turgunbaev, Marat, Coates, Laura C., Gottlieb, Alice, Magrey, Marina, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Scher, Jose U., Siegel, Evan, Siegel, Michael, Walsh, Jessica A., Turner, Amy S., and Reston, James
- Subjects
Medicine - Abstract
Supplemental Material, Singh_ART40726_Supplementary_Appendix_5_Evidence_Report for 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis by Jasvinder A. Singh, Gordon Guyatt, Alexis Ogdie, Dafna D. Gladman, Chad Deal, Atul Deodhar, Maureen Dubreuil, Jonathan Dunham, M. Elaine Husni, Sarah Kenny, Jennifer Kwan-Morley, Janice Lin, Paula Marchetta, Philip J. Mease, Joseph F. Merola, Julie Miner, Christopher T. Ritchlin, Bernadette Siaton, Benjamin J. Smith, Abby S. Van Voorhees, Anna Helena Jonsson, Amit Aakash Shah, Nancy Sullivan, Marat Turgunbaev, Laura C. Coates, Alice Gottlieb, Marina Magrey, W. Benjamin Nowell, Ana-Maria Orbai, Soumya M. Reddy, Jose U. Scher, Evan Siegel, Michael Siegel, Jessica A. Walsh, Amy S. Turner, and James Reston in Journal of Psoriasis and Psoriatic Arthritis
- Published
- 2018
- Full Text
- View/download PDF
22. Transancestral mapping and genetic load in systemic lupus erythematosus
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Langefeld, Carl D, Ainsworth, Hannah C, Cunninghame Graham, Deborah S, Kelly, Jennifer A, Comeau, Mary E, Marion, Miranda C, Howard, Timothy D, Ramos, Paula S, Croker, Jennifer A, Morris, David L, Sandling, Johanna K, Almlöf, Jonas Carlsson, Acevedo-Vásquez, Eduardo M, Alarcón, Graciela S, Babini, Alejandra M, Baca, Vicente, Bengtsson, Anders A, Berbotto, Guillermo A, Bijl, Marc, Brown, Elizabeth E, Brunner, Hermine I, Cardiel, Mario H, Catoggio, Luis, Cervera, Ricard, Cucho-Venegas, Jorge M, Dahlqvist, Solbritt Rantapää, D'Alfonso, Sandra, Da Silva, Berta Martins, de la Rúa Figueroa, Iñigo, Doria, Andrea, Edberg, Jeffrey C, Endreffy, Emőke, Esquivel-Valerio, Jorge A, Fortin, Paul R, Freedman, Barry I, Frostegård, Johan, García, Mercedes A, de la Torre, Ignacio García, Gilkeson, Gary S, Gladman, Dafna D, Gunnarsson, Iva, Guthridge, Joel M, Huggins, Jennifer L, James, Judith A, Kallenberg, Cees GM, Kamen, Diane L, Karp, David R, Kaufman, Kenneth M, Kottyan, Leah C, Kovács, László, Laustrup, Helle, Lauwerys, Bernard R, Li, Quan-Zhen, Maradiaga-Ceceña, Marco A, Martín, Javier, McCune, Joseph M, McWilliams, David R, Merrill, Joan T, Miranda, Pedro, Moctezuma, José F, Nath, Swapan K, Niewold, Timothy B, Orozco, Lorena, Ortego-Centeno, Norberto, Petri, Michelle, Pineau, Christian A, Pons-Estel, Bernardo A, Pope, Janet, Raj, Prithvi, Ramsey-Goldman, Rosalind, Reveille, John D, Russell, Laurie P, Sabio, José M, Aguilar-Salinas, Carlos A, Scherbarth, Hugo R, Scorza, Raffaella, Seldin, Michael F, Sjöwall, Christopher, Svenungsson, Elisabet, Thompson, Susan D, Toloza, Sergio MA, Truedsson, Lennart, Tusié-Luna, Teresa, Vasconcelos, Carlos, Vilá, Luis M, Wallace, Daniel J, Weisman, Michael H, Wither, Joan E, Bhangale, Tushar, Oksenberg, Jorge R, Rioux, John D, Gregersen, Peter K, Syvänen, Ann-Christine, Rönnblom, Lars, Criswell, Lindsey A, Jacob, Chaim O, Sivils, Kathy L, Tsao, Betty P, Schanberg, Laura E, and Behrens, Timothy W
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Multifactorial Inheritance ,American Native Continental Ancestry Group ,European Continental Ancestry Group ,Black People ,Lupus ,Autoimmune Disease ,White People ,Clinical Research ,immune system diseases ,HLA Antigens ,Insertional ,Genetics ,2.1 Biological and endogenous factors ,Humans ,Aetiology ,Age of Onset ,Polymorphism ,skin and connective tissue diseases ,American Indian or Alaska Native ,Sequence Deletion ,African Continental Ancestry Group ,Lupus Erythematosus ,Whites ,Inflammatory and immune system ,Systemic ,Hispanic or Latino ,Single Nucleotide ,Blacks ,Logistic Models ,Mutagenesis ,Case-Control Studies ,Genetic Load ,Hispanic Americans - Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (P
- Published
- 2017
23. Mood Disorders in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
- Author
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Hanly, John G., Su, Li, Urowitz, Murray B., Romero-Diaz, Juanita, Gordon, Caroline, Bae, Sang-Cheol, Bernatsky, Sasha, Clarke, Ann E., Wallace, Daniel J., Merrill, Joan T., Isenberg, David A., Rahman, Anisur, Ginzler, Ellen M., Petri, Michelle, Bruce, Ian N., Dooley, M. A., Fortin, Paul, Gladman, Dafna D., Sanchez-Guerrero, Jorge, Steinsson, Kristjan, Ramsey-Goldman, Rosalind, Khamashta, Munther A., Aranow, Cynthia, Alarcón, Graciela S., Fessler, Barri J., Manzi, Susan, Nived, Ola, Sturfelt, Gunnar K., Zoma, Asad A., van Vollenhoven, Ronald F., Ramos-Casals, Manuel, Ruiz-Irastorza, Guillermo, Lim, S. Sam, Kalunian, Kenneth C., Inanc, Murat, Kamen, Diane L., Peschken, Christine A., Jacobsen, Soren, Askanase, Anca, Theriault, Chris, Thompson, Kara, Farewell, Vernon, Su, Li [0000-0003-0919-3462], Farewell, Vernon [0000-0001-6704-5295], and Apollo - University of Cambridge Repository
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Adult ,Male ,Internationality ,Mood Disorders ,Incidence ,Black People ,Hispanic or Latino ,Middle Aged ,Article ,White People ,Cohort Studies ,Asian People ,Disease Progression ,Quality of Life ,Humans ,Lupus Erythematosus, Systemic ,Regression Analysis ,Female ,Prospective Studies ,Autoantibodies - Abstract
OBJECTIVE: To examine the frequency, characteristics, and outcome of mood disorders, as well as clinical and autoantibody associations, in a multiethnic/racial, prospective inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: Patients were assessed annually for mood disorders (4 types, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) and 18 other neuropsychiatric events. Global disease activity scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage scores (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]), and Short Form 36 subscales, mental and physical component summary scores were collected. Time to event, linear and ordinal regressions, and multi-state models were used as appropriate. RESULTS: Among the 1,827 patients with SLE, 88.9% were female, and 48.9% were Caucasian. The mean ± SD age of the patients was 35.1 ± 13.3 years, disease duration was 5.6 ± 4.8 months, and the length of followup was 4.7 ± 3.5 years. During the course of the study, 863 (47.2%) of the 1,827 patients had 1,627 neuropsychiatric events. Mood disorders occurred in 232 (12.7%) of 1,827 patients, and 98 (38.3%) of 256 mood disorder events were attributed to SLE. The estimated cumulative incidence of any mood disorder after 10 years was 17.7% (95% confidence interval 15.1, 20.2%). A greater risk of mood disorder was associated with concurrent neuropsychiatric events (P ≤ 0.01), and a lower risk was associated with Asian race/ethnicity (P = 0.01) and treatment with immunosuppressive drugs (P = 0.003). Mood disorders were associated with lower mental health and mental component summary scores but not with the SLEDAI-2K, SDI, or lupus autoantibodies. Among the 232 patients with depression, 168 (72.4%) were treated with antidepressants. One hundred twenty-six (49.2%) of 256 mood disorders resolved in 117 (50.4%) of 232 patients. CONCLUSION: Mood disorders, the second most frequent neuropsychiatric event in patients with SLE, have a negative impact on health-related quality of life and improve over time. The lack of association with global SLE disease activity, cumulative organ damage, and lupus autoantibodies emphasizes the multifactorial etiology of mood disorders and a role for non-lupus-specific therapies.
- Published
- 2015
24. Recent advances in understanding and managing psoriatic arthritis
- Author
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Gladman, Dafna D.
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0301 basic medicine ,medicine.medical_specialty ,Psychological intervention ,Review ,Disease ,General Biochemistry, Genetics and Molecular Biology ,TNF inhibitors ,Immunopharmacology & Hematologic Pharmacology ,03 medical and health sciences ,Psoriatic arthritis ,Joint disease ,0302 clinical medicine ,CASPAR ,Quality of life ,Psoriasis ,Anesthesiology ,Dermatologic Pharmacology ,Genetics of the Immune System ,Medicine ,Immune & Inflammatory Rheumatic Diseases (incl. Arthritis) ,General Pharmacology, Toxicology and Pharmaceutics ,Intensive care medicine ,030203 arthritis & rheumatology ,Musculoskeletal Pharmacology ,General Immunology and Microbiology ,business.industry ,Articles ,psoriasis ,General Medicine ,medicine.disease ,Innate Immunity ,Psoriasis & Other Inflammatory Diseases ,PsA ,Open data ,030104 developmental biology ,Immunology ,business ,Medical Genetics - Abstract
This article reviews recent advances in psoriatic arthritis (PsA) over the past several years with emphasis on early diagnosis, better understanding of pathogenesis, and new therapeutic approaches. Early diagnosis is important, since people who present late do not fare as well. There are a number of clinical, laboratory, and ultrasound features that can help identify patients destined to develop PsA, and several screening tools have been developed. It is recognized that genetic and epigenetic factors, as well as T cells and cytokines, play a role in the pathogenesis of PsA, and several targets have been identified for therapeutic interventions. New therapies have been developed and tested in PsA and have been found to be highly effective for both skin and joint manifestations of the disease. The expectation is that, in the future, PsA patients will be treated early and more aggressively and that there will not be significant progression of joint damage. Moreover, with effective treatment of the skin and joint disease and management of risk factors for the comorbidities, we can expect to reduce their occurrence and further reduce the excess mortality and reduced quality of life and function in these patients.
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- 2016
25. Cerebrovascular Events in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
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Hanly, John G, Li, Qiuju, Su, Li, Urowitz, Murray B, Gordon, Caroline, Bae, Sang-Cheol, Romero-Diaz, Juanita, Sanchez-Guerrero, Jorge, Bernatsky, Sasha, Clarke, Ann E, Wallace, Daniel J, Isenberg, David A, Rahman, Anisur, Merrill, Joan T, Fortin, Paul, Gladman, Dafna D, Bruce, Ian N, Petri, Michelle, Ginzler, Ellen M, Dooley, MA, Steinsson, Kristjan, Ramsey-Goldman, Rosalind, Zoma, Asad A, Manzi, Susan, Nived, Ola, Jonsen, Andreas, Khamashta, Munther A, Alarcón, Graciela S, Chatham, Winn, Van Vollenhoven, Ronald F, Aranow, Cynthia, Mackay, Meggan, Ruiz-Irastorza, Guillermo, Ramos-Casals, Manuel, Lim, S Sam, Inanc, Murat, Kalunian, Kenneth C, Jacobsen, Soren, Peschken, Christine A, Kamen, Diane L, Askanase, Anca, Theriault, Chris, and Farewell, Vernon
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Adult ,Male ,Cerebrovascular Disorders ,Young Adult ,Quality of Life ,Humans ,Lupus Erythematosus, Systemic ,Female ,Prospective Studies ,Middle Aged ,skin and connective tissue diseases ,3. Good health - Abstract
OBJECTIVE: To determine the frequency, characteristics, and outcomes of cerebrovascular events (CerVEs), as well as clinical and autoantibody associations in a multiethnic/racial inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: A total of 1,826 patients were assessed annually for 19 neuropsychiatric (NP) events, including 5 types of CerVEs: 1) stroke, 2) transient ischemia, 3) chronic multifocal ischemia, 4) subarachnoid/intracranial hemorrhage, and 5) sinus thrombosis. Global disease activity (Systemic Lupus Erythematosus Disease [SLE] Activity Index 2000), damage scores (SLE International Collaborating Clinics/American College of Rheumatology Damage Index), and Short Form 36 (SF-36) scores were collected. Time to event, linear and logistic regressions, and multistate models were used as appropriate. RESULTS: CerVEs were the fourth most frequent NP event: 82 of 1,826 patients had 109 events; of these events, 103 were attributed to SLE, and 44 were identified at the time of enrollment. The predominant events were stroke (60 of 109 patients) and transient ischemia (28 of 109 patients). CerVEs were associated with other NP events attributed to SLE, non-SLE-attributed NP events, African ancestry (at US SLICC sites), and increased organ damage scores. Lupus anticoagulant increased the risk of first stroke and sinus thrombosis and transient ischemic attack. Physician assessment indicated resolution or improvement in the majority of patients, but patients reported sustained reduction in SF-36 summary and subscale scores following a CerVE. CONCLUSION: CerVEs, the fourth most frequent NP event in SLE, are usually attributable to lupus. In contrast to good physician-reported outcomes, patients reported a sustained reduction in health-related quality of life following a CerVE.
26. Economic Evaluation of Damage Accrual in an International SLE Inception Cohort
- Author
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Barber, Megan, Bruce, Ian N., Urowitz, Murray, Hanly, John G., Su, Li, Romero-Diaz, Juanita, Gordon, Caroline, Bae, Sang-Cheol, Bernatsky, Sasha, Wallace, Daniel J., Merrill, Joan T., Isenberg, David A., Rahman, Anisur, Ginzler, Ellen M., Petri, Michelle, Dooley, Mary Anne, Fortin, Paul R., Gladman, Dafna D., Sanchez-Guerrero, Jorge, Steinsson, Kristjan, Ramsey-Goldman, Rosalind, Khamashta, M., Aranow, Cynthia, Alarcon, Graciela S., Fessler, Barri J., Manzi, Susan, Nived, Ola, Jonsen, Andreas, Zoma, Asad, Vollenhoven, Ronald F., Manuel Ramos-Casals, Ruiz-Irastorza, Guillermo, Lim, S. Sam, Kalunian, Kenneth C., Inanc, Murat, Kamen, Diane L., Peschken, Christine A., Jacobsen, Soren, Askanase, Anca, Buyon, Jill P., Theriault, Chris, Farewell, Vernon, and Clarke, Ann E.
27. Mood Disorders in Systemic Lupus Erythematousus (SLE): Results from an International, Inception Cohort Study
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Hanly, John G., Su, Li, Urowitz, Murray, Romero-Diaz, Juanita, Gordon, Caroline, Bae, Sang-Cheol, Bernatsky, Sasha R., Clarke, Ann E., Wallace, Daniel J., Merrill, Joan T., Isenberg, David A., Rahman, Anisur, Ginzler, Ellen M., Fortin, Paul, Gladman, Dafna D., Sanchez-Guerrero, Jorge, Petri, Michelle A., Bruce, Ian, Dooley, Mary Anne, Ramsey-Goldman, Rosalind, Aranow, Cynthia, Alarcon, Graciela S., Fessler, Barri J., Steinsson, Kristjan, Nived, Ola, Sturfelt, Gunnar K., Manzi, Susan, Khamashta, Munther A., Vollenhoven, Ronald F., Zoma, Asad, Ramos-Casals, Manuel, Guillermo Ruiz-Irastorza, Lim, S. Sam, Stoll, Thomas, Inanc, Murat, Kalunian, Kenneth C., Kamen, Diane L., Maddison, Peter, Peschken, Christine A., Jacobsen, Soren, Askanase, Anca, Buyon, Jill P., Theriault, Chris, Thompson, Kara, and Farewell, Vernon
- Subjects
Clinical Sciences ,Immunology ,Public Health and Health Services ,Arthritis & Rheumatology
28. GRADE-Based Recommendations for the Diagnosis and Monitoring of Systemic Lupus Erythematosus in Canada
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Keeling, Stephanie, Alabdurubalnabi, Zainab, Avina-Zubieta, J. Antonio, Barr, Susan, Bergeron, Louise, Bernatsky, Sasha, Bourre-Tessier, Josiane, Clarke, Ann E., Baril-Dionne, Alexandra, Dutz, Jan, Ensworth, Stephanie, Fifi-Mah, Aurore, Fortin, Paul R., Gladman, Dafna D., Haaland, Derek, Hanly, John G., Hiraki, Linda T., Hussein, Sara, Legault, Kimberly, Levy, Deborah M., Lim, Lily, Matsos, Mark, Mcdonald, Emily, Medina-Rosas, Jorge, Pardo, Jordi Pardo, Peschken, Christine A., Pineau, Christian, Pope, Janet E., Rader, Tamara, Reynolds, Jennifer, Silverman, Earl, Suitner, Manon, Tselios, Konstantinos, Urowitz, Murray, Zahi Touma, Vinet, Evelyne, and Santesso, Nancy
29. The Initial Presentation of Cerebrovascular Disease Attributed to Lupus Is Most Frequent Early in the Disease Course: Results from an International, Inception Cohort Study
- Author
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Hanly, John G., Li, Qiuju, Su, Li, Urowitz, Murray, Romero-Diaz, Juanita, Gordon, C., Bae, Sang-Cheol, Bernatsky, Sasha R., Clarke, Ann, Wallace, Daniel J., Merrill, Joan T., Isenberg, David A., Rahman, Anisur, Ginzler, Ellen M., Petri, Michelle, Bruce, Ian N., Dooley, Mary Anne, Fortin, Paul, Gladman, Dafna D., Sanchez-Guerrero, Jorge, Steinsson, Kristjan, Ramsey-Goldman, Rosalind, Khamashta, Munther, Aranow, Cynthia, Alarcon, Graciela S., Fessler, Barri J., Manzi, Susan, Nived, Ola, Sturfelt, Gunnar K., Zoma, Asad, Vollenhoven, Ronald F., Ramos-Casals, Manuel, Guillermo Ruiz-Irastorza, Lim, S. Sam, Kalunian, Kenneth C., Inanc, Murat, Kamen, Diane L., Peschken, Christine A., Jacobsen, Soren, Askanase, Anca, Theriault, Chris, and Farewell, Vernon
30. Mood Disorders in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
- Author
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Hanly, John G, Su, Li, Urowitz, Murray B, Romero-Diaz, Juanita, Gordon, Caroline, Bae, Sang-Cheol, Bernatsky, Sasha, Clarke, Ann E, Wallace, Daniel J, Merrill, Joan T, Isenberg, David A, Rahman, Anisur, Ginzler, Ellen M, Petri, Michelle, Bruce, Ian N, Dooley, MA, Fortin, Paul, Gladman, Dafna D, Sanchez-Guerrero, Jorge, Steinsson, Kristjan, Ramsey-Goldman, Rosalind, Khamashta, Munther A, Aranow, Cynthia, Alarcón, Graciela S, Fessler, Barri J, Manzi, Susan, Nived, Ola, Sturfelt, Gunnar K, Zoma, Asad A, Van Vollenhoven, Ronald F, Ramos-Casals, Manuel, Ruiz-Irastorza, Guillermo, Lim, S Sam, Kalunian, Kenneth C, Inanc, Murat, Kamen, Diane L, Peschken, Christine A, Jacobsen, Soren, Askanase, Anca, Theriault, Chris, Thompson, Kara, and Farewell, Vernon
- Subjects
Adult ,Male ,Internationality ,Mood Disorders ,Incidence ,Black People ,Hispanic or Latino ,Middle Aged ,White People ,3. Good health ,Cohort Studies ,Asian People ,Disease Progression ,Quality of Life ,Humans ,Lupus Erythematosus, Systemic ,Regression Analysis ,Female ,Prospective Studies ,Autoantibodies - Abstract
OBJECTIVE: To examine the frequency, characteristics, and outcome of mood disorders, as well as clinical and autoantibody associations, in a multiethnic/racial, prospective inception cohort of patients with systemic lupus erythematosus (SLE). METHODS: Patients were assessed annually for mood disorders (4 types, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) and 18 other neuropsychiatric events. Global disease activity scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage scores (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]), and Short Form 36 subscales, mental and physical component summary scores were collected. Time to event, linear and ordinal regressions, and multi-state models were used as appropriate. RESULTS: Among the 1,827 patients with SLE, 88.9% were female, and 48.9% were Caucasian. The mean ± SD age of the patients was 35.1 ± 13.3 years, disease duration was 5.6 ± 4.8 months, and the length of followup was 4.7 ± 3.5 years. During the course of the study, 863 (47.2%) of the 1,827 patients had 1,627 neuropsychiatric events. Mood disorders occurred in 232 (12.7%) of 1,827 patients, and 98 (38.3%) of 256 mood disorder events were attributed to SLE. The estimated cumulative incidence of any mood disorder after 10 years was 17.7% (95% confidence interval 15.1, 20.2%). A greater risk of mood disorder was associated with concurrent neuropsychiatric events (P ≤ 0.01), and a lower risk was associated with Asian race/ethnicity (P = 0.01) and treatment with immunosuppressive drugs (P = 0.003). Mood disorders were associated with lower mental health and mental component summary scores but not with the SLEDAI-2K, SDI, or lupus autoantibodies. Among the 232 patients with depression, 168 (72.4%) were treated with antidepressants. One hundred twenty-six (49.2%) of 256 mood disorders resolved in 117 (50.4%) of 232 patients. CONCLUSION: Mood disorders, the second most frequent neuropsychiatric event in patients with SLE, have a negative impact on health-related quality of life and improve over time. The lack of association with global SLE disease activity, cumulative organ damage, and lupus autoantibodies emphasizes the multifactorial etiology of mood disorders and a role for non-lupus-specific therapies.
31. Outcome of Lupus Nephritis and Impact on Health Related Quality of Life: Results from an International, Prospective, Inception Cohort Study
- Author
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Hanly, John G., O Keeffe, Aidan, Su, Li, Urowitz, Murray B., Romero-Diaz, Juanita, Gordon, Caroline, Bae, Sang-Cheol, Bernatsky, Sasha R., Clarke, Ann E., Wallace, Daniel J., Merrill, Joan T., Isenberg, David A., Rahman, Anisur, Ginzler, Ellen M., Fortin, Paul, Gladman, Dafna D., Sanchez-Guerrero, Jorge, Petri, Michelle A., Bruce, Ian, Dooley, Mary Anne, Ramsey-Goldman, Rosalind, Aranow, Cynthia, Alarcon, Graciela S., Fessler, Barri, Steinsson, Kristjan, Nived, Ola, Sturfelt, Gunnar, Manzi, Susan, Khamashta, Munther A., Vollenhoven, Ronald F., Zoma, Asad, Ramos-Casals, Manuel, Guillermo Ruiz-Irastorza, Lim, S. Sam, Stoll, Thomas, Inanc, Murat, Kalunian, Kenneth C., Kamen, Diane L., Maddison, Peter, Peschken, Christine A., Jacobsen, Soren, Askanase, Anca, Buyon, Jill P., Theriault, Chris, Thompson, Kara, and Farewell, Vernon
32. Construction and Validation of a Frailty Index As a Novel Health Measure in Systemic Lupus Erythematosus
- Author
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Legge, Alexandra, Kirkland, Susan, Rockwood, Kenneth, Andreou, Pantelis, Bae, Sang-Cheol, Gordon, Caroline, Romero-Diaz, Juanita, Sanchez-Guerrero, Jorge, Wallace, Daniel, Bernatsky, Sasha, Clarkel, Ann E., Merrill, Joan T., Ginzlert, Ellen M., Fortin, Paul R., Gladman, Dafna D., Urowitz, Murray, Bruce, Ian N., Isenbere, David A., Rahman, Anisur, Alarcon, Graciela S., Petri, Michelle, Khamashta, Munther A., Dooley, Mary, Ramsey-Goldman, Rosalind, Manzi, Susan, Steinsson, Kristjan, Zoma, Asad A., Aranow, Cynthia, Mackay, Meggan, Ruiz-Irastorza, Guillermo, Lim, S. Sam, Inanc, Murat, Vollenhoven, Ronald F., Jonsen, Andreas, Nived, Ola, Manuel Ramos-Casals, Kamen, Diane L., Kalunian, Kenneth C., Jacobsen, Soren, Peschken, Christine A., Askanase, Anca, and Hanly, John G.
33. Economic Evaluation of Lupus Nephritis in an International Inception Cohort: Comparing the Hospitalization, Medication, Dialysis, and Procedure Costs of Those with and without Nephritis
- Author
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Barber, Megan, Hanly, John G., O Keeffe, Aidan, Su, Li, Urowitz, Murray, St Pierre, Yvan, Romero-Diaz, Juanita, Gordon, C., Bae, Sang-Cheol, Bernatsky, Sasha, Wallace, Daniel J., Merrill, Joan T., Isenberg, David A., Rahman, Anisur, Ginzler, Ellen M., Fortin, Paul R., Gladman, Dafna D., Sanchez-Guerrero, Jorge, Petri, Michelle, Bruce, Ian N., Dooley, Mary Anne, Ramsey-Goldman, Rosalind, Aranow, Cynthia, Alarcon, Graciela S., Chatham, W. Winn, Steinsson, Kristjan, Nived, Ola, Sturfelt, Gunnar K., Manzi, Susan, Khamashta, Munther, Vollenhoven, Ronald F., Zoma, Asad, Ramos-Casals, Manel, Guillermo Ruiz-Irastorza, Lim, S. Sam, Stoll, Thomas, Inanc, Murat, Kalunian, Kenneth C., Kamen, Diane L., Maddison, Peter, Peschken, Christine A., Jacobsen, Soren, Askanase, Anca, Buyon, Jill P., Theriault, Chris, Thompson, Kara, Farewell, Vernon, and Clarke, Ann E.
34. SLEDAI-2K Describing Features Over the Past 10 Days and 30 Days
- Author
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Zahi Touma, Urowitz, Murray B., and Gladman, Dafna D.
35. Cancer in an SLE Inception Cohort: Smoking May out-Perform Tumor Markers As a Risk Predictor
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Bernatsky, Sasha, Urowitz, Murray, Hanly, John G., Clarke, Ann E., Fritzler, Marvin J., Gordon, Caroline, Romero-Diaz, Juanita, Alarcon, Graciela S., Bae, Sang-Cheol, Petri, Michelle, Merrill, Joan T., Wallace, Daniel J., Fortin, Paul R., Gladman, Dafna D., Isenberg, David A., Rahman, Anisur, Manzi, Susan, Nived, Ola, Sturfelt, Gunnar K., Peschken, Christine A., Sanchez-Guerrero, Jorge, Guillermo Ruiz-Irastorza, Aranow, Cynthia, Vollenhoven, Ronald F., Zoma, Asad, Steinsson, Kristjan, Khamashta, Munther A., Ginzler, Ellen M., Askanase, Anca, Kalunian, Kenneth C., Dooley, Mary Anne, Lim, S. Sam, Kamen, Diane L., Jacobsen, Soren, Ramos-Casals, Manuel, Inanc, Murat, Lee, Jennifer L. F., and Ramsey-Goldman, Rosalind
36. Factors associated with damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort
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Bruce, Ian N, O'Keeffe, Aidan G, Farewell, Vern, Hanly, John G, Manzi, Susan, Su, Li, Gladman, Dafna D, Bae, Sang-Cheol, Sanchez-Guerrero, Jorge, Romero-Diaz, Juanita, Gordon, Caroline, Wallace, Daniel J, Clarke, Ann E, Bernatsky, Sasha, Ginzler, Ellen M, Isenberg, David A, Rahman, Anisur, Merrill, Joan T, Alarcón, Graciela S, Fessler, Barri J, Fortin, Paul R, Petri, Michelle, Steinsson, Kristjan, Dooley, Mary Anne, Khamashta, Munther A, Ramsey-Goldman, Rosalind, Zoma, Asad A, Sturfelt, Gunnar K, Nived, Ola, Aranow, Cynthia, Mackay, Meggan, Ramos-Casals, Manuel, Van Vollenhoven, Ronald F, Kalunian, Kenneth C, Ruiz-Irastorza, Guillermo, Lim, Sam, Kamen, Diane L, Peschken, Christine A, Inanc, Murat, and Urowitz, Murray B
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Inflammation ,Adult ,Male ,Health Status ,Kaplan-Meier Estimate ,Middle Aged ,Systemic Lupus Erythematosus ,3. Good health ,Cohort Studies ,Young Adult ,Outcomes research ,Disease Progression ,Ethnicity ,Quality of Life ,Corticosteroids ,Humans ,Lupus Erythematosus, Systemic ,Female ,Longitudinal Studies ,Prospective Studies ,Proportional Hazards Models - Abstract
BACKGROUND AND AIMS: We studied damage accrual and factors determining development and progression of damage in an international cohort of systemic lupus erythematosus (SLE) patients. METHODS: The Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort recruited patients within 15 months of developing four or more 1997 American College of Rheumatology (ACR) criteria for SLE; the SLICC/ACR damage index (SDI) was measured annually. We assessed relative rates of transition using maximum likelihood estimation in a multistate model. The Kaplan-Meier method estimated the probabilities for time to first increase in SDI score and Cox regression analysis was used to assess mortality. RESULTS: We recruited 1722 patients; mean (SD) age 35.0 (13.4) years at cohort entry. Patients with damage at enrolment were more likely to have further worsening of SDI (SDI 0 vs ≥1; p
37. Economic Evaluation of Lupus Nephritis in the Systemic Lupus International Collaborating Clinics Inception Cohort Using a Multistate Model Approach
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Barber, Megan RW, Hanly, John G, Su, Li, Urowitz, Murray B, St Pierre, Yvan, Romero-Diaz, Juanita, Gordon, Caroline, Bae, Sang-Cheol, Bernatsky, Sasha, Wallace, Daniel J, Isenberg, David A, Rahman, Anisur, Ginzler, Ellen M, Petri, Michelle, Bruce, Ian N, Fortin, Paul R, Gladman, Dafna D, Sanchez-Guerrero, Jorge, Ramsey-Goldman, Rosalind, Khamashta, Munther A, Aranow, Cynthia, Mackay, Meggan, Alarcón, Graciela S, Manzi, Susan, Nived, Ola, Jönsen, Andreas, Zoma, Asad A, Van Vollenhoven, Ronald F, Ramos-Casals, Manuel, Ruiz-Irastorza, Guillermo, Lim, S Sam, Kalunian, Kenneth C, Inanc, Murat, Kamen, Diane L, Peschken, Christine A, Jacobsen, Soren, Askanase, Anca, Theriault, Chris, Farewell, Vernon, and Clarke, Ann E
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Adult ,Cohort Studies ,Male ,Young Adult ,Models, Economic ,Humans ,Female ,Health Care Costs ,Middle Aged ,urologic and male genital diseases ,Lupus Nephritis ,3. Good health - Abstract
OBJECTIVE: Little is known about the long-term costs of lupus nephritis (LN). The costs were compared between patients with and without LN using multistate modeling. METHODS: Patients from 32 centers in 11 countries were enrolled in the Systemic Lupus International Collaborating Clinics inception cohort within 15 months of diagnosis and provided annual data on renal function, hospitalizations, medications, dialysis, and selected procedures. LN was diagnosed by renal biopsy or the American College of Rheumatology classification criteria. Renal function was assessed annually using the estimated glomerular filtration rate (GFR) or estimated proteinuria. A multistate model was used to predict 10-year cumulative costs by multiplying annual costs associated with each renal state by the expected state duration. RESULTS: A total of 1,545 patients participated; 89.3% were women, the mean ± age at diagnosis was 35.2 ± 13.4 years, 49% were white, and the mean followup duration was 6.3 ± 3.3 years. LN developed in 39.4% of these patients by the end of followup. Ten-year cumulative costs were greater in those with LN and an estimated glomerular filtration rate (GFR) 60 ml/minute) or with LN and estimated proteinuria >3 gm/day ($84,040 versus $20,499 if no LN and estimated proteinuria
38. Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study
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Hanly, John G, Li, Qiuju, Su, Li, Urowitz, Murray B, Gordon, Caroline, Bae, Sang-Cheol, Romero-Diaz, Juanita, Sanchez-Guerrero, Jorge, Bernatsky, Sasha, Clarke, Ann E, Wallace, Daniel J, Isenberg, David A, Rahman, Anisur, Merrill, Joan T, Fortin, Paul R, Gladman, Dafna D, Bruce, Ian N, Petri, Michelle, Ginzler, Ellen M, Dooley, MA, Steinsson, Kristjan, Ramsey-Goldman, Rosalind, Zoma, Asad A, Manzi, Susan, Nived, Ola, Jonsen, Andreas, Khamashta, Munther A, Alarcón, Graciela S, Svenungsson, Elisabet, Van Vollenhoven, Ronald F, Aranow, Cynthia, Mackay, Meggan, Ruiz-Irastorza, Guillermo, Ramos-Casals, Manuel, Lim, S Sam, Inanc, Murat, Kalunian, Kenneth C, Jacobsen, Soren, Peschken, Christine A, Kamen, Diane L, Askanase, Anca, Theriault, Chris, and Farewell, Vernon
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Adult ,Male ,Lupus Vasculitis, Central Nervous System ,Mononeuropathies ,Age Factors ,Peripheral Nervous System Diseases ,Middle Aged ,Severity of Illness Index ,Cranial Nerve Diseases ,3. Good health ,Cohort Studies ,Young Adult ,Multivariate Analysis ,Humans ,Lupus Erythematosus, Systemic ,Female ,Proportional Hazards Models - Abstract
OBJECTIVE: To determine the frequency, clinical characteristics, associations, and outcomes of different types of peripheral nervous system (PNS) disease in a multiethnic/multiracial, prospective inception cohort of systemic lupus erythematosus (SLE) patients. METHODS: Patients were evaluated annually for 19 neuropsychiatric (NP) events including 7 types of PNS disease. SLE disease activity, organ damage, autoantibodies, and patient and physician assessment of outcome were measured. Time to event and linear regressions were used as appropriate. RESULTS: Of 1,827 SLE patients, 88.8% were female, and 48.8% were white. The mean ± SD age was 35.1 ± 13.3 years, disease duration at enrollment was 5.6 ± 4.2 months, and follow-up was 7.6 ± 4.6 years. There were 161 PNS events in 139 (7.6%) of 1,827 patients. The predominant events were peripheral neuropathy (66 of 161 [41.0%]), mononeuropathy (44 of 161 [27.3%]), and cranial neuropathy (39 of 161 [24.2%]), and the majority were attributed to SLE. Multivariate Cox regressions suggested longer time to resolution in patients with a history of neuropathy, older age at SLE diagnosis, higher SLE Disease Activity Index 2000 scores, and for peripheral neuropathy versus other neuropathies. Neuropathy was associated with significantly lower Short Form 36 (SF-36) physical and mental component summary scores versus no NP events. According to physician assessment, the majority of neuropathies resolved or improved over time, which was associated with improvements in SF-36 summary scores for peripheral neuropathy and mononeuropathy. CONCLUSION: PNS disease is an important component of total NPSLE and has a significant negative impact on health-related quality of life. The outcome is favorable for most patients, but our findings indicate that several factors are associated with longer time to resolution.
39. Association of Systemic Lupus Erythematosus (SLE) Genetic Susceptibility Loci with Lupus Nephritis in Children and Adults with SLE
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Webber, Declan, Cao, Jingling, Dominguez, Daniela, Gladman, Dafna D., Levy, Deborah M., Ng, Lawrence, Andrew Paterson, Touma, Zahi, Urowitz, Murray, Wither, Joan E., Silverman, Earl, and Hiraki, Linda
40. Impact of Disease Course on Atherosclerotic Vascular Events, Osteoporosis and Osteonecrosis in Systemic Lupus Erythematosus
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Tselios, Konstantinos, Gladman, Dafna D., Zahi Touma, Su, Jiandong, Anderson, Nicole, and Urowitz, Murray
41. European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) SLE classification criteria item performance
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Carlos Vasconcelos, Zahi Touma, Elena Massarotti, Chiara Tani, Ivan Padjen, Gabriela Schmajuk, Ricard Cervera, Guillermo Ruiz-Irastorza, Matthias Schneider, Florence Assan, Edward M Vital, Bernadett Halda-Kiss, Pier Luigi Meroni, Marvin J. Fritzler, Georg Stummvoll, Murray B. Urowitz, Diane L. Kamen, Dinesh Khanna, Maria G Tektonidou, Falk Hiepe, Raphaèle Seror, Søren Jacobsen, Michelle Jung, Marta Mosca, Sule Yavuz, László Czirják, Winfried Graninger, Sara K. Tedeschi, Bimba F. Hoyer, David I. Daikh, Bevra H. Hahn, Karen H. Costenbader, Rosalind Ramsey-Goldman, David Wofsy, Sindhu R. Johnson, Ann E. Clarke, Joseph M. McCune, Nicolai Leuchten, Kirsten Lerstrøm, Yoshiya Tanaka, Betty Diamond, David Jayne, Peter M. Izmirly, Josef S Smolen, George Bertsias, Ralph Brinks, Dimitrios T. Boumpas, Ray Naden, Juanita Romero-Diaz, Mary K. Crow, Gábor Kumánovics, Iñigo Rúa-Figueroa, Daniel J. Wallace, Thomas Dörner, José M. Pego-Reigosa, Jorge Sanchez-Guerrero, Martin Aringer, Xavier Mariette, Branimir Anić, Sarfaraz Hasni, Andrea Doria, Dafna D. Gladman, Nathalie Costedoat-Chalumeau, Tak Mao Chan, Aringer, Martin [0000-0003-4471-8375], Dörner, Thomas [0000-0002-6478-7725], Boumpas, Dimitrios T [0000-0002-9812-4671], Costedoat-Chalumeau, Nathalie [0000-0002-1555-9021], Diamond, Betty [0000-0002-3250-3804], Gladman, Dafna D [0000-0002-9074-0592], Khanna, Dinesh [0000-0003-1412-4453], Ruiz-Irastorza, Guillermo [0000-0001-7788-1043], Urowitz, Murray [0000-0001-7506-9166], Tedeschi, Sara K [0000-0001-9475-1363], Touma, Zahi [0000-0001-5177-2076], Assan, Florence [0000-0001-6988-6178], Crow, Mary K [0000-0002-7881-2020], Doria, Andrea [0000-0003-0548-4983], Rúa-Figueroa, Íñigo [0000-0002-7894-1690], Tanaka, Yoshiya [0000-0002-0807-7139], Tektonidou, Maria G [0000-0003-2238-0975], Vital, Edward M [0000-0003-1637-4755], Wallace, Daniel J [0000-0002-2502-1372], Yavuz, Sule [0000-0001-5053-6426], Meroni, Pier Luigi [0000-0002-3394-1451], Fritzler, Marvin J [0000-0003-1652-6608], Johnson, Sindhu R [0000-0003-0591-2976], and Apollo - University of Cambridge Repository
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musculoskeletal diseases ,medicine.medical_specialty ,Anti-nuclear antibody ,autoantibodies ,Immunology ,Population ,Acr criteria ,Sensitivity and Specificity ,General Biochemistry, Genetics and Molecular Biology ,Cohort Studies ,Rheumatology ,immune system diseases ,Internal medicine ,Rheumatic Diseases ,medicine ,Immunology and Allergy ,antibodies ,Humans ,Lupus Erythematosus, Systemic ,education ,skin and connective tissue diseases ,education.field_of_study ,Lupus erythematosus ,business.industry ,Autoantibody ,systemic ,medicine.disease ,United States ,antiphospholipid ,lupus erythematosus ,synovitis ,Antibodies, Antinuclear ,Delirium ,medicine.symptom ,business ,Rheumatism - Abstract
Background/objectives The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 classification criteria for systemic lupus erythematosus system showed high specificity, while attaining also high sensitivity. We hereby analysed the performance of the individual criteria items and their contribution to the overall performance of the criteria. Methods We combined the EULAR/ACR derivation and validation cohorts for a total of 1197 systemic lupus erythematosus (SLE) and n=1074 non-SLE patients with a variety of conditions mimicking SLE, such as other autoimmune diseases, and calculated the sensitivity and specificity for antinuclear antibodies (ANA) and the 23 specific criteria items. We also tested performance omitting the EULAR/ACR criteria attribution rule, which defines that items are only counted if not more likely explained by a cause other than SLE. Results Positive ANA, the new entry criterion, was 99.5% sensitive, but only 19.4% specific, against a non-SLE population that included other inflammatory rheumatic, infectious, malignant and metabolic diseases. The specific criteria items were highly variable in sensitivity (from 0.42% for delirium and 1.84% for psychosis to 75.6% for antibodies to double-stranded DNA), but their specificity was uniformly high, with low C3 or C4 (83.0%) and leucopenia Conclusions Changing the position of the highly sensitive, non-specific ANA to an entry criterion and the attribution rule resulted in a specificity of >80% for all items, explaining the higher overall specificity of the criteria set.
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- 2021
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42. Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities
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Diane L. Kamen, Pier Luigi Meroni, Sarfaraz Hasni, Martin Aringer, Edward M Vital, Xavier Mariette, Maria G Tektonidou, Jorge Sanchez-Guerrero, Michelle Jung, Falk Hiepe, Gábor Kumánovics, Carlos Vasconcelos, George Bertsias, David Jayne, Branimir Anić, Juanita Romero-Diaz, Marta Mosca, Nathalie Costedoat-Chalumeau, Ivan Padjen, Ricard Cervera, László Czirják, Dafna D. Gladman, Bimba F. Hoyer, Søren Jacobsen, Sindhu R. Johnson, Zahi Touma, Kirsten Lerstrøm, Tak Mao Chan, Florence Assan, David I. Daikh, Karen H. Costenbader, Rosalind Ramsey-Goldman, Sara K. Tedeschi, Guillermo Ruiz-Irastorza, Elena Massarotti, Chiara Tani, Josef S Smolen, Andrea Doria, Betty Diamond, Mary K. Crow, Bernadett Halda-Kiss, Ralph Brinks, Murray B. Urowitz, Bevra H. Hahn, Iñigo Rúa-Figueroa, Winfried Graninger, Sule Yavuz, Daniel J. Wallace, José M. Pego-Reigosa, Nicolai Leuchten, Peter M. Izmirly, Ray Naden, Thomas Dörner, Dinesh Khanna, Raphaèle Seror, David Wofsy, Ann E. Clarke, Joseph M. McCune, Matthias Schneider, Georg Stummvoll, Gabriela Schmajuk, Yoshiya Tanaka, Marvin J. Fritzler, Dimitrios T. Boumpas, Johnson, Sindhu R [0000-0003-0591-2976], Boumpas, Dimitrios T [0000-0002-9812-4671], Costedoat-Chalumeau, Nathalie [0000-0002-1555-9021], Gladman, Dafna D [0000-0002-9074-0592], Khanna, Dinesh [0000-0003-1412-4453], Ruiz-Irastorza, Guillermo [0000-0001-7788-1043], Urowitz, Murray [0000-0001-7506-9166], Assan, Florence [0000-0001-6988-6178], Doria, Andrea [0000-0003-0548-4983], Rúa-Figueroa, Íñigo [0000-0002-7894-1690], Tanaka, Yoshiya [0000-0002-0807-7139], Tektonidou, Maria G [0000-0003-2238-0975], Yavuz, Sule [0000-0001-5053-6426], Meroni, Pier Luigi [0000-0002-3394-1451], Dörner, Thomas [0000-0002-6478-7725], Aringer, Martin [0000-0003-4471-8375], and Apollo - University of Cambridge Repository
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musculoskeletal diseases ,Male ,medicine.medical_specialty ,Immunology ,Lupus nephritis ,Ethnic group ,Sensitivity and Specificity ,Severity of Illness Index ,General Biochemistry, Genetics and Molecular Biology ,outcomes research ,Rheumatology ,systemic lupus erythematosus ,immune system diseases ,Internal medicine ,Epidemiology ,medicine ,Immunology and Allergy ,Humans ,Lupus Erythematosus, Systemic ,skin and connective tissue diseases ,epidemiology ,lupus nephritis ,business.industry ,Patient Selection ,Early disease ,medicine.disease ,Cohort ,Female ,Outcomes research ,business ,Rheumatism - Abstract
Funder: American College of Rheumatology Research and Education Foundation; FundRef: http://dx.doi.org/10.13039/100000960, Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases; FundRef: http://dx.doi.org/10.13039/100000069, Funder: European League Against Rheumatism; FundRef: http://dx.doi.org/10.13039/501100008741, OBJECTIVES: The European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) 2019 Classification Criteria for systemic lupus erythematosus (SLE) have been validated with high sensitivity and specificity. We evaluated the performance of the new criteria with regard to disease duration, sex and race/ethnicity, and compared its performance against the Systemic Lupus International Collaborating Clinics (SLICC) 2012 and ACR 1982/1997 criteria. METHODS: Twenty-one SLE centres from 16 countries submitted SLE cases and mimicking controls to form the validation cohort. The sensitivity and specificity of the EULAR/ACR 2019, SLICC 2012 and ACR 1982/1997 criteria were evaluated. RESULTS: The cohort consisted of female (n=1098), male (n=172), Asian (n=118), black (n=68), Hispanic (n=124) and white (n=941) patients; with an SLE duration of 1 to
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- 2020
43. Physician's Global Assessment in Psoriatic Arthritis: A Multicenter GRAPPA Study
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Maria Grazia Catanoso, Paolo Contu, Alessandro Mathieu, Philip J. Mease, E. Lubrano, Matteo Piga, William J. Taylor, Paul P. Tak, Carlo Salvarani, Claudia Sardu, Alberto Cauli, Salvatore D'Angelo, Antonio Marchesoni, Arno W R van Kuijk, Ilona Ujfalussy, Joachim Robert Kalden, John A. Flynn, Raffaele Scarpa, Alberto Floris, Philip S. Helliwell, Dafna D. Gladman, Francesco Caso, Giovanni Porru, Sueli Carneiro, Ignazio Olivieri, Francesca Desiati, Cauli, Alberto, Gladman, Dafna D., Mathieu, Alessandro, Olivieri, Ignazio, Porru, Giovanni, Tak, Paul P., Sardu, Claudia, Scarpa, Raffaele, Marchesoni, Antonio, Taylor, William J., Salvarani, Carlo, Kalden, Joachim, Lubrano, Ennio, Carneiro, Sueli, Piga, Matteo, Floris, Alberto, Desiati, Francesca, Flynn, John A., D'Angelo, Salvatore, Van Kuijk, Arno W. R., Catanoso, Maria Grazia, Caso, Francesco, Contu, Paolo, Ujfalussy, Ilona, Helliwell, Philip S., and Mease, Philip J.
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Adult ,Male ,medicine.medical_specialty ,DOMAINS ,Physician's Global Assessment ,Intraclass correlation ,Visual analogue scale ,Immunology ,Domains Instrument ,Severity of Illness Index ,Disease activity ,03 medical and health sciences ,Psoriatic arthritis ,Diagnostic Self Evaluation ,0302 clinical medicine ,Rheumatology ,Internal medicine ,Physicians ,Medicine ,Immunology and Allergy ,Humans ,In patient ,PHYSICIAN’S GLOBAL ASSESSMENT ,030212 general & internal medicine ,Reliability (statistics) ,Aged ,030203 arthritis & rheumatology ,ASSESSMENT MEASURES ,business.industry ,Arthritis, Psoriatic ,PSORIATIC ARTHRITIS ,Reproducibility of Results ,Therapeutic decision making ,Assessment Measure ,INSTRUMENTS ,Middle Aged ,medicine.disease ,Psoriatic Arthriti ,Nail disease ,Female ,Joints ,Symptom Assessment ,business - Abstract
Objective.Physician’s global assessment (PGA) of disease activity is a major determinant of therapeutic decision making. This study assesses the reliability of the PGA, measured by means of 0–100 mm visual analog scale (VAS), and the additional use of separate VAS scales for musculoskeletal (PhysMSK) and dermatologic (PhysSk) manifestations in patients with psoriatic arthritis (PsA).Methods.Sixteen centers from 8 countries enrolled 319 consecutive patients with PsA. PGA, PhysMSK, and PhysSk evaluation forms were administered at enrollment (W0) and after 1 week (W1). Detailed clinical data regarding musculoskeletal (MSK) manifestations, as well as dermatological assessment, were recorded.Results.Comparison of W0 and W1 scores showed no significant variation (intraclass correlation coefficients were PGA 0.87, PhysMSK 0.86, PhysSk 0.78), demonstrating the reliability of the instrument. PGA scores were dependent on PhysMSK and PhysSk (p < 0.0001) with a major effect of the MSK component (B = 0.69) compared to skin (B = 0.32). PhysMSK was correlated with the number of swollen joints, tender joints, and presence of dactylitis (p < 0.0001). PhysSk scores were correlated with the extent of skin psoriasis and by face, buttocks or intergluteal, and feet involvement (p < 0.0001). Finally, physician and patient assessments were compared showing frequent mismatch and a scattered dot plot: PGA versus patient’s global assessment (r = 0.36), PhysMSK versus patient MSK (r = 0.39), and PhysSk versus patient skin (r = 0.49).Conclusion.PGA assessed by means of VAS is a reliable tool to assess MSK and dermatological disease activity. PGA may diverge from patient self-evaluation. Because MSK and skin/nail disease activity may diverge, it is suggested that both PhysMSK and PhysSk are assessed.
- Published
- 2018
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