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2. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
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Jiao, Wei, Atwal, Gurnit, Polak, Paz, Karlic, Rosa, Cuppen, Edwin, Al-Shahrour, Fatima, Bailey, Peter J, Biankin, Andrew V, Boutros, Paul C, Campbell, Peter J, Chang, David K, Cooke, Susanna L, Deshpande, Vikram, Faltas, Bishoy M, Faquin, William C, Garraway, Levi, Getz, Gad, Grimmond, Sean M, Haider, Syed, Hoadley, Katherine A, Kaiser, Vera B, Kato, Mamoru, Kübler, Kirsten, Lazar, Alexander J, Li, Constance H, Louis, David N, Margolin, Adam, Martin, Sancha, Nahal-Bose, Hardeep K, Nielsen, G Petur, Nik-Zainal, Serena, Omberg, Larsson, P’ng, Christine, Perry, Marc D, Rheinbay, Esther, Rubin, Mark A, Semple, Colin A, Sgroi, Dennis C, Shibata, Tatsuhiro, Siebert, Reiner, Smith, Jaclyn, Stein, Lincoln D, Stobbe, Miranda D, Sun, Ren X, Thai, Kevin, Wright, Derek W, Wu, Chin-Lee, Yuan, Ke, Zhang, Junjun, Danyi, Alexandra, de Ridder, Jeroen, van Herpen, Carla, Lolkema, Martijn P, Steeghs, Neeltje, Morris, Quaid D, Aaltonen, Lauri A, Abascal, Federico, Abeshouse, Adam, Aburatani, Hiroyuki, Adams, David J, Agrawal, Nishant, Ahn, Keun Soo, Ahn, Sung-Min, Aikata, Hiroshi, Akbani, Rehan, Akdemir, Kadir C, Al-Ahmadie, Hikmat, Al-Sedairy, Sultan T, Alawi, Malik, Albert, Monique, Aldape, Kenneth, Alexandrov, Ludmil B, Ally, Adrian, Alsop, Kathryn, Alvarez, Eva G, Amary, Fernanda, Amin, Samirkumar B, Aminou, Brice, Ammerpohl, Ole, Anderson, Matthew J, Ang, Yeng, Antonello, Davide, Anur, Pavana, Aparicio, Samuel, Appelbaum, Elizabeth L, Arai, Yasuhito, Aretz, Axel, Arihiro, Koji, Ariizumi, Shun-ichi, Armenia, Joshua, Arnould, Laurent, Asa, Sylvia, Assenov, Yassen, Aukema, Sietse, Auman, J Todd, Aure, Miriam RR, Awadalla, Philip, Aymerich, Marta, Bader, Gary D, Baez-Ortega, Adrian, Bailey, Matthew H, Balasundaram, Miruna, Balu, Saianand, Bandopadhayay, Pratiti, Banks, Rosamonde E, Barbi, Stefano, Barbour, Andrew P, Barenboim, Jonathan, Barnholtz-Sloan, Jill, Barr, Hugh, Barrera, Elisabet, Bartlett, John, Bartolome, Javier, Bassi, Claudio, Bathe, Oliver F, Baumhoer, Daniel, Bavi, Prashant, Baylin, Stephen B, Bazant, Wojciech, Beardsmore, Duncan, Beck, Timothy A, Behjati, Sam, Behren, Andreas, Niu, Beifang, Bell, Cindy, Beltran, Sergi, Benz, Christopher, Berchuck, Andrew, Bergmann, Anke K, Bergstrom, Erik N, Berman, Benjamin P, Berney, Daniel M, Bernhart, Stephan H, Beroukhim, Rameen, Berrios, Mario, Bersani, Samantha, Bertl, Johanna, Betancourt, Miguel, Bhandari, Vinayak, Bhosle, Shriram G, Bieg, Matthias, Bigner, Darell, Binder, Hans, Birney, Ewan, Birrer, Michael, Biswas, Nidhan K, Bjerkehagen, Bodil, Bodenheimer, Tom, Boice, Lori, Bonizzato, Giada, De Bono, Johann S, Boot, Arnoud, Bootwalla, Moiz S, Borg, Ake, Borkhardt, Arndt, Boroevich, Keith A, Borozan, Ivan, Borst, Christoph, Bosenberg, Marcus, Bosio, Mattia, Boultwood, Jacqueline, Bourque, Guillaume, Bova, G Steven, Bowen, David T, Bowlby, Reanne, Bowtell, David DL, Boyault, Sandrine, Boyce, Rich, Boyd, Jeffrey, Brazma, Alvis, Brennan, Paul, Brewer, Daniel S, Brinkman, Arie B, Bristow, Robert G, 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Yiwen, Chen, Zhaohong, Cherniack, Andrew D, Chien, Jeremy, Chiew, Yoke-Eng, Chin, Suet-Feung, Cho, Juok, Cho, Sunghoon, Choi, Jung Kyoon, Choi, Wan, Chomienne, Christine, Chong, Zechen, Choo, Su Pin, Chou, Angela, Christ, Angelika N, Christie, Elizabeth L, Chuah, Eric, Cibulskis, Carrie, Cibulskis, Kristian, Cingarlini, Sara, Clapham, Peter, Claviez, Alexander, Cleary, Sean, Cloonan, Nicole, Cmero, Marek, Collins, Colin C, Connor, Ashton A, Cooper, Colin S, Cope, Leslie, Corbo, Vincenzo, Cordes, Matthew G, Cordner, Stephen M, Cortés-Ciriano, Isidro, Covington, Kyle, Cowin, Prue A, Craft, Brian, Craft, David, Creighton, Chad J, Cun, Yupeng, Curley, Erin, Cutcutache, Ioana, Czajka, Karolina, Czerniak, Bogdan, Dagg, Rebecca A, Danilova, Ludmila, Davi, Maria Vittoria, Davidson, Natalie R, Davies, Helen, Davis, Ian J, Davis-Dusenbery, Brandi N, Dawson, Kevin J, De La Vega, Francisco M, De Paoli-Iseppi, Ricardo, Defreitas, Timothy, Dei Tos, Angelo P, Delaneau, Olivier, Demchok, John A, Demeulemeester, Jonas, Demidov, German M, Demircioğlu, Deniz, Dennis, Nening M, Denroche, Robert E, Dentro, Stefan C, Desai, Nikita, Deshwar, Amit G, Desmedt, Christine, Deu-Pons, Jordi, Dhalla, Noreen, Dhani, Neesha C, Dhingra, Priyanka, Dhir, Rajiv, DiBiase, Anthony, Diamanti, Klev, Ding, Li, Ding, Shuai, Dinh, Huy Q, Dirix, Luc, Doddapaneni, HarshaVardhan, Donmez, Nilgun, Dow, Michelle T, Drapkin, Ronny, Drechsel, Oliver, Drews, Ruben M, Serge, Serge, Dudderidge, Tim, Dueso-Barroso, Ana, Dunford, Andrew J, Dunn, Michael, Dursi, Lewis Jonathan, Duthie, Fraser R, Dutton-Regester, Ken, Eagles, Jenna, Easton, Douglas F, Edmonds, Stuart, Edwards, Paul A, Edwards, Sandra E, Eeles, Rosalind A, Ehinger, Anna, Eils, Juergen, Eils, Roland, El-Naggar, Adel, Eldridge, Matthew, Ellrott, Kyle, Erkek, Serap, Escaramis, Georgia, Espiritu, Shadrielle MG, Estivill, Xavier, Etemadmoghadam, Dariush, Eyfjord, Jorunn E, Fan, Daiming, Fan, Yu, Farcas, Claudiu, Fassan, Matteo, Fatima, Aquila, Favero, Francesco, Fayzullaev, Nodirjon, Felau, Ina, Fereday, Sian, Ferguson, Martin L, Ferretti, Vincent, Feuerbach, Lars, Field, Matthew A, Fink, J Lynn, Finocchiaro, Gaetano, Fisher, Cyril, Fittall, Matthew W, Fitzgerald, Anna, Fitzgerald, Rebecca C, Flanagan, Adrienne M, Fleshner, Neil E, Flicek, Paul, Foekens, John A, Fong, Kwun M, Fonseca, Nuno A, Foster, Christopher S, Fox, Natalie S, Fraser, Michael, Frazer, Scott, Frenkel-Morgenstern, Milana, Friedman, William, Frigola, Joan, Fronick, Catrina C, Fujimoto, Akihiro, Fujita, Masashi, Fukayama, Masashi, Fulton, Lucinda A, Fulton, Robert S, Furuta, Mayuko, Futreal, P Andrew, Füllgrabe, Anja, Gabriel, Stacey B, Gallinger, Steven, Gambacorti-Passerini, Carlo, Gao, Jianjiong, Gao, Shengjie, Garred, Øystein, Garrison, Erik, Garsed, Dale W, Gehlenborg, Nils, Gelpi, Josep LL, George, Joshy, Gerhard, Daniela S, Gerhauser, Clarissa, Gershenwald, Jeffrey E, Gerstein, Mark, Gerstung, Moritz, Ghori, Mohammed, Ghossein, Ronald, Giama, Nasra H, Gibbs, Richard A, Gibson, Bob, Gill, Anthony J, Gill, Pelvender, Giri, Dilip D, Glodzik, Dominik, Gnanapragasam, Vincent J, Goebler, Maria Elisabeth, Goldman, Mary J, Gomez, Carmen, Gonzalez, Santiago, Gonzalez-Perez, Abel, Gordenin, Dmitry A, Gossage, James, Gotoh, Kunihito, Govindan, Ramaswamy, Grabau, Dorthe, Graham, Janet S, Grant, Robert C, Green, Anthony R, Green, Eric, Greger, Liliana, Grehan, Nicola, Grimaldi, Sonia, Grossman, Robert L, Grundhoff, Adam, Gundem, Gunes, Guo, Qianyun, Gupta, Manaswi, Gupta, Shailja, Gut, Ivo G, Gut, Marta, Göke, Jonathan, Ha, Gavin, Haake, Andrea, Haan, David, Haas, Siegfried, Haase, Kerstin, Haber, James E, Habermann, Nina, Hach, Faraz, Hama, Natsuko, Hamdy, Freddie C, Hamilton, Anne, Hamilton, Mark P, Han, Leng, Hanna, George B, Hansmann, Martin, Haradhvala, Nicholas J, Harismendy, Olivier, Harliwong, Ivon, Harmanci, Arif O, Harrington, Eoghan, Hasegawa, Takanori, Haussler, David, Hawkins, Steve, Hayami, Shinya, Hayashi, Shuto, Hayes, D Neil, Hayes, Stephen J, Hayward, Nicholas K, Hazell, Steven, He, Yao, Heath, Allison P, Heath, Simon C, Hedley, David, Hegde, Apurva M, Heiman, David I, Heinold, Michael C, Heins, Zachary, Heisler, Lawrence E, Hellstrom-Lindberg, Eva, Helmy, Mohamed, Heo, Seong Gu, Hepperla, Austin J, Heredia-Genestar, José María, Herrmann, Carl, Hersey, Peter, Hess, Julian M, Hilmarsdottir, Holmfridur, Hinton, Jonathan, Hirano, Satoshi, Hiraoka, Nobuyoshi, Hobolth, Asger, Hodzic, Ermin, Hoell, Jessica I, Hoffmann, Steve, Hofmann, Oliver, Holbrook, Andrea, Holik, Aliaksei Z, Hollingsworth, Michael A, Holmes, Oliver, Holt, Robert A, Hong, Chen, Hong, Eun Pyo, Hong, Jongwhi H, Hooijer, Gerrit K, Hornshøj, Henrik, Hosoda, Fumie, Hou, Yong, Hovestadt, Volker, Howat, William, Hoyle, Alan P, Hruban, Ralph H, Hu, Jianhong, Hu, Taobo, Hua, Xing, Huang, Kuan-lin, Huang, Mei, Huang, Mi Ni, Huang, Vincent, Huang, Yi, Huber, Wolfgang, Hudson, Thomas J, Hummel, Michael, Hung, Jillian A, Huntsman, David, Hupp, Ted R, Huse, Jason, Huska, Matthew R, Hutter, Barbara, Hutter, Carolyn M, Hübschmann, Daniel, Iacobuzio-Donahue, Christine A, Imbusch, Charles David, Imielinski, Marcin, Imoto, Seiya, Isaacs, William B, Isaev, Keren, Ishikawa, Shumpei, Iskar, Murat, Islam, SM Ashiqul, Ittmann, Michael, Ivkovic, Sinisa, Izarzugaza, Jose MG, Jacquemier, Jocelyne, Jakrot, Valerie, Jamieson, Nigel B, Jang, Gun Ho, Jang, Se Jin, Jayaseelan, Joy C, Jayasinghe, Reyka, Jefferys, Stuart R, Jegalian, Karine, Jennings, Jennifer L, Jeon, Seung-Hyup, Jerman, Lara, Ji, Yuan, Johansson, Peter A, Johns, Amber L, Johns, Jeremy, Johnson, Rory, Johnson, Todd A, Jolly, Clemency, Joly, Yann, Jonasson, Jon G, Jones, Corbin D, Jones, David R, Jones, David TW, Jones, Nic, Jones, Steven JM, Jonkers, Jos, Ju, Young Seok, Juhl, Hartmut, Jung, Jongsun, Juul, Malene, Juul, Randi Istrup, Juul, Sissel, Jäger, Natalie, Kabbe, Rolf, Kahles, Andre, Kahraman, Abdullah, Kakavand, Hojabr, Kalimuthu, Sangeetha, von Kalle, Christof, Kang, Koo Jeong, Karaszi, Katalin, Karlan, Beth, Karlić, Rosa, Karsch, Dennis, Kasaian, Katayoon, Kassahn, Karin S, Katai, Hitoshi, Katoh, Hiroto, Kawakami, Yoshiiku, Kay, Jonathan D, Kazakoff, Stephen H, Kazanov, Marat D, Keays, Maria, Kebebew, Electron, Kefford, Richard F, Kellis, Manolis, Kench, James G, Kennedy, Catherine J, Kerssemakers, Jules NA, Khoo, David, Khoo, Vincent, Khuntikeo, Narong, Khurana, Ekta, Kilpinen, Helena, Kim, Hark Kyun, Kim, Hyung-Lae, Kim, Hyung-Yong, Kim, Hyunghwan, Kim, Jaegil, Kim, Jihoon, Kim, Jong K, Kim, Youngwook, King, Tari A, Klapper, Wolfram, Kleinheinz, Kortine, Klimczak, Leszek J, Knappskog, Stian, Kneba, Michael, Knoppers, Bartha M, Koh, Youngil, Komorowski, Jan, Komura, Daisuke, Komura, Mitsuhiro, Kong, Gu, Kool, Marcel, Korbel, Jan O, Korchina, Viktoriya, Korshunov, Andrey, Koscher, Michael, Koster, Roelof, Kote-Jarai, Zsofia, Koures, Antonios, Kovacevic, Milena, Kremeyer, Barbara, Kretzmer, Helene, Kreuz, Markus, Krishnamurthy, Savitri, Kube, Dieter, Kumar, Kiran, Kumar, Pardeep, Kumar, Sushant, Kumar, Yogesh, Kundra, Ritika, Küppers, Ralf, Lagergren, Jesper, Lai, Phillip H, Laird, Peter W, Lakhani, Sunil R, Lalansingh, Christopher M, Lalonde, Emilie, Lamaze, Fabien C, Lambert, Adam, Lander, Eric, Landgraf, Pablo, Landoni, Luca, Langerød, Anita, Lanzós, Andrés, Larsimont, Denis, Larsson, Erik, Lathrop, Mark, Lau, Loretta MS, Lawerenz, Chris, Lawlor, Rita T, Lawrence, Michael S, Lazic, Ana Mijalkovic, Le, Xuan, Lee, Darlene, Lee, Donghoon, Lee, Eunjung Alice, Lee, Hee Jin, Lee, Jake June-Koo, Lee, Jeong-Yeon, Lee, Juhee, Lee, Ming Ta Michael, Lee-Six, Henry, Lehmann, Kjong-Van, Lehrach, Hans, Lenze, Dido, Leonard, Conrad R, Leongamornlert, Daniel A, Leshchiner, Ignaty, Letourneau, Louis, Letunic, Ivica, Levine, Douglas A, Lewis, Lora, Ley, Tim, Li, Chang, Li, Haiyan Irene, Li, Jun, Li, Lin, Li, Shantao, Li, Siliang, Li, Xiaobo, Li, Xiaotong, Li, Xinyue, Li, Yilong, Liang, Han, Liang, Sheng-Ben, Lichter, Peter, Lin, Pei, Lin, Ziao, Linehan, WM, Lingjærde, Ole Christian, Liu, Dongbing, Liu, Eric Minwei, Liu, Fei-Fei Fei, Liu, Fenglin, Liu, Jia, Liu, Xingmin, Livingstone, Julie, Livitz, Dimitri, Livni, Naomi, Lochovsky, Lucas, Loeffler, Markus, Long, Georgina V, Lopez-Guillermo, Armando, Lou, Shaoke, Lovat, Laurence B, Lu, Yiling, Lu, Yong-Jie, Lu, Youyong, Luchini, Claudio, Lungu, Ilinca, Luo, Xuemei, Luxton, Hayley J, Lynch, Andy G, Lype, Lisa, López, Cristina, López-Otín, Carlos, Z, Eric, Ma, Yussanne, MacGrogan, Gaetan, MacRae, Shona, Macintyre, Geoff, Madsen, Tobias, Maejima, Kazuhiro, Mafficini, Andrea, Maglinte, Dennis T, Maitra, Arindam, Majumder, Partha P, Malcovati, Luca, Malikic, Salem, Malleo, Giuseppe, Mann, Graham J, Mantovani-Löffler, Luisa, Marchal, Kathleen, Marchegiani, Giovanni, Mardis, Elaine R, Margolin, Adam A, Marin, Maximillian G, Markowetz, Florian, Markowski, Julia, Marks, Jeffrey, Marques-Bonet, Tomas, Marra, Marco A, Marsden, Luke, Martens, John WM, Martin-Subero, Jose I, Martincorena, Iñigo, Martinez-Fundichely, Alexander, Maruvka, Yosef E, Mashl, R Jay, Massie, Charlie E, Matthew, Thomas J, Matthews, Lucy, Mayer, Erik, Mayes, Simon, Mayo, Michael, Mbabaali, Faridah, McCune, Karen, McDermott, Ultan, McGillivray, Patrick D, McLellan, Michael D, McPherson, John D, McPherson, John R, McPherson, Treasa A, Meier, Samuel R, Meng, Alice, Meng, Shaowu, Menzies, Andrew, Merrett, Neil D, Merson, Sue, Meyerson, Matthew, Meyerson, William, Mieczkowski, Piotr A, Mihaiescu, George L, Mijalkovic, Sanja, Mikkelsen, Tom, Milella, Michele, Mileshkin, Linda, Miller, Christopher A, Miller, David K, Miller, Jessica K, Mills, Gordon B, Milovanovic, Ana, Minner, Sarah, Miotto, Marco, Arnau, Gisela Mir, Mirabello, Lisa, Mitchell, Chris, Mitchell, Thomas J, Miyano, Satoru, Miyoshi, Naoki, Mizuno, Shinichi, Molnár-Gábor, Fruzsina, Moore, Malcolm J, Moore, Richard A, Morganella, Sandro, Morrison, Carl, Mose, Lisle E, Moser, Catherine D, Muiños, Ferran, Mularoni, Loris, Mungall, Andrew J, Mungall, Karen, Musgrove, Elizabeth A, Mustonen, Ville, Mutch, David, Muyas, Francesc, Muzny, Donna M, Muñoz, Alfonso, Myers, Jerome, Myklebost, Ola, Möller, Peter, Nagae, Genta, Nagrial, Adnan M, Nakagama, Hitoshi, Nakagawa, Hidewaki, Nakamura, Hiromi, Nakamura, Toru, Nakano, Kaoru, Nandi, Tannistha, Nangalia, Jyoti, Nastic, Mia, Navarro, Arcadi, Navarro, Fabio CP, Neal, David E, Nettekoven, Gerd, Newell, Felicity, Newhouse, Steven J, Newton, Yulia, Ng, Alvin Wei Tian, Ng, Anthony, Nicholson, Jonathan, Nicol, David, Nie, Yongzhan, Nielsen, Morten Muhlig, Noble, Michael S, Nones, Katia, Northcott, Paul A, Notta, Faiyaz, O’Connor, Brian D, O’Donnell, Peter, O’Donovan, Maria, O’Meara, Sarah, O’Neill, Brian Patrick, O’Neill, J Robert, Ocana, David, Ochoa, Angelica, Oesper, Layla, Ogden, Christopher, Ohdan, Hideki, Ohi, Kazuhiro, Ohno-Machado, Lucila, Oien, Karin A, Ojesina, Akinyemi I, Ojima, Hidenori, Okusaka, Takuji, Ong, Choon Kiat, Ossowski, Stephan, Ott, German, Ouellette, BF Francis, Paczkowska, Marta, Paiella, Salvatore, Pairojkul, Chawalit, Pajic, Marina, Pan-Hammarström, Qiang, Papaemmanuil, Elli, Papatheodorou, Irene, Paramasivam, Nagarajan, Park, Ji Wan, Park, Joong-Won, Park, Keunchil, Park, Kiejung, Park, Peter J, Parker, Joel S, Parsons, Simon L, Pass, Harvey, Pasternack, Danielle, Pastore, Alessandro, Patch, Ann-Marie, Pauporté, Iris, Pea, Antonio, Pearson, John V, Pedamallu, Chandra Sekhar, Pedersen, Jakob Skou, Pederzoli, Paolo, Peifer, Martin, Pennell, Nathan A, Perou, Charles M, Petersen, Gloria M, Peto, Myron, Petrelli, Nicholas, Petryszak, Robert, Pfister, Stefan M, Phillips, Mark, Pich, Oriol, Pickett, Hilda A, Pihl, Todd D, Pillay, Nischalan, Pinder, Sarah, Pinese, Mark, Pinho, Andreia V, Pitkänen, Esa, Pivot, Xavier, Piñeiro-Yáñez, Elena, Planko, Laura, Plass, Christoph, Pons, Tirso, Popescu, Irinel, Potapova, Olga, Prasad, Aparna, Preston, Shaun R, Prinz, Manuel, Pritchard, Antonia L, Prokopec, Stephenie D, Provenzano, Elena, Puente, Xose S, Puig, Sonia, Puiggròs, Montserrat, Pulido-Tamayo, Sergio, Pupo, Gulietta M, Purdie, Colin A, Quinn, Michael C, Rabionet, Raquel, Rader, Janet S, Radlwimmer, Bernhard, Radovic, Petar, Raeder, Benjamin, Raine, Keiran M, Ramakrishna, Manasa, Ramakrishnan, Kamna, Ramalingam, Suresh, Raphael, Benjamin J, Rathmell, W Kimryn, Rausch, Tobias, Reifenberger, Guido, Reimand, Jüri, Reis-Filho, Jorge, Reuter, Victor, Reyes-Salazar, Iker, Reyna, Matthew A, Reynolds, Sheila M, Riazalhosseini, Yasser, Richardson, Andrea L, Richter, Julia, Ringel, Matthew, Ringnér, Markus, Rino, Yasushi, Rippe, Karsten, Roach, Jeffrey, Roberts, Lewis R, Roberts, Nicola D, Roberts, Steven A, Robertson, A Gordon, Robertson, Alan J, Rodriguez, Javier Bartolomé, Rodriguez-Martin, Bernardo, Rodríguez-González, F Germán, Roehrl, Michael HA, Rohde, Marius, Rokutan, Hirofumi, Romieu, Gilles, Rooman, Ilse, Roques, Tom, Rosebrock, Daniel, Rosenberg, Mara, Rosenstiel, Philip C, Rosenwald, Andreas, Rowe, Edward W, Royo, Romina, Rozen, Steven G, Rubanova, Yulia, Rubio-Perez, Carlota, Rudneva, Vasilisa A, Rusev, Borislav C, Ruzzenente, Andrea, Rätsch, Gunnar, Sabarinathan, Radhakrishnan, Sabelnykova, Veronica Y, Sadeghi, Sara, Sahinalp, S Cenk, Saini, Natalie, Saito-Adachi, Mihoko, Saksena, Gordon, Salcedo, Adriana, Salgado, Roberto, Salichos, Leonidas, Sallari, Richard, Saller, Charles, Salvia, Roberto, Sam, Michelle, Samra, Jaswinder S, Sanchez-Vega, Francisco, Sander, Chris, Sanders, Grant, Sarin, Rajiv, Sarrafi, Iman, Sasaki-Oku, Aya, Sauer, Torill, Sauter, Guido, Saw, Robyn PM, Scardoni, Maria, Scarlett, Christopher J, Scarpa, Aldo, Scelo, Ghislaine, Schadendorf, Dirk, Schein, Jacqueline E, Schilhabel, Markus B, Schlesner, Matthias, Schlomm, Thorsten, Schmidt, Heather K, Schramm, Sarah-Jane, Schreiber, Stefan, Schultz, Nikolaus, Schumacher, Steven E, Schwarz, Roland F, Scolyer, Richard A, Scott, David, Scully, Ralph, Seethala, Raja, Segre, Ayellet V, Selander, Iris, Senbabaoglu, Yasin, Sengupta, Subhajit, Sereni, Elisabetta, Serra, Stefano, Shackleton, Mark, Shah, Nimish C, Shahabi, Sagedeh, Shang, Catherine A, Shang, Ping, Shapira, Ofer, Shelton, Troy, Shen, Ciyue, Shen, Hui, Shepherd, Rebecca, Shi, Ruian, Shi, Yan, Shiah, Yu-Jia, Shih, Juliann, Shimizu, Eigo, Shimizu, Kiyo, Shin, Seung Jun, Shiraishi, Yuichi, Shmaya, Tal, Shmulevich, Ilya, Shorser, Solomon I, Short, Charles, Shrestha, Raunak, Shringarpure, Suyash S, Shriver, Craig, Shuai, Shimin, Sidiropoulos, Nikos, Sieuwerts, Anieta M, Sieverling, Lina, Signoretti, Sabina, Sikora, Katarzyna O, Simbolo, Michele, Simon, Ronald, Simons, Janae V, Simpson, Jared T, Simpson, Peter T, Singer, Samuel, Sinnott-Armstrong, Nasa, Sipahimalani, Payal, Skelly, Tara J, Smid, Marcel, Smith-McCune, Karen, Socci, Nicholas D, Sofia, Heidi J, Soloway, Matthew G, Song, Lei, Sood, Anil K, Sothi, Sharmila, Sotiriou, Christos, Soulette, Cameron M, Span, Paul N, Spellman, Paul T, Sperandio, Nicola, Spillane, Andrew J, Spiro, Oliver, Spring, Jonathan, Staaf, Johan, Stadler, Peter F, Staib, Peter, Stark, Stefan G, Stebbings, Lucy, Stefánsson, Ólafur Andri, Stegle, Oliver, Stenhouse, Alasdair, Stewart, Chip, Stilgenbauer, Stephan, Stratton, Michael R, Stretch, Jonathan R, Struck, Adam J, Stuart, Joshua M, Stunnenberg, Henk G, Su, Hong, Su, Xiaoping, Sungalee, Stephanie, Susak, Hana, Suzuki, Akihiro, Sweep, Fred, Szczepanowski, Monika, Sültmann, Holger, Yugawa, Takashi, Tam, Angela, Tamborero, David, Tan, Benita Kiat Tee, Tan, Donghui, Tan, Patrick, Tanaka, Hiroko, Taniguchi, Hirokazu, Tanskanen, Tomas J, Tarabichi, Maxime, Tarnuzzer, Roy, Tarpey, Patrick, Taschuk, Morgan L, Tatsuno, Kenji, Tavaré, Simon, Taylor, Darrin F, Taylor-Weiner, Amaro, Teague, Jon W, Teh, Bin Tean, Tembe, Varsha, Temes, Javier, Thayer, Sarah P, Thiessen, Nina, Thomas, Gilles, Thomas, Sarah, Thompson, Alan, Thompson, Alastair M, Thompson, John FF, Thompson, R Houston, Thorne, Heather, Thorne, Leigh B, Thorogood, Adrian, Tiao, Grace, Tijanic, Nebojsa, Timms, Lee E, Tirabosco, Roberto, Tojo, Marta, Tommasi, Stefania, Toon, Christopher W, Toprak, Umut H, Torrents, David, Tortora, Giampaolo, Tost, Jörg, Totoki, Yasushi, Townend, David, Traficante, Nadia, Treilleux, Isabelle, Trotta, Jean-Rémi, Trümper, Lorenz HP, Tsao, Ming, Tsunoda, Tatsuhiko, MC Tubio, Jose, Tucker, Olga, Turkington, Richard, Turner, Daniel J, Tutt, Andrew, Ueno, Masaki, Ueno, Naoto T, Umbricht, Christopher, Umer, Husen M, Underwood, Timothy J, Urban, Lara, Urushidate, Tomoko, Ushiku, Tetsuo, Uusküla-Reimand, Liis, Valencia, Alfonso, Van Den Berg, David J, Van Laere, Steven, Van Loo, Peter, Van Meir, Erwin G, Van den Eynden, Gert G, Van der Kwast, Theodorus, Vasudev, Naveen, Vazquez, Miguel, Vedururu, Ravikiran, Veluvolu, Umadevi, Vembu, Shankar, Verbeke, Lieven PC, Vermeulen, Peter, Verrill, Clare, Viari, Alain, Vicente, David, Vicentini, Caterina, VijayRaghavan, K, Viksna, Juris, Vilain, Ricardo E, Villasante, Izar, Vincent-Salomon, Anne, Visakorpi, Tapio, Voet, Douglas, Vyas, 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Rui, Xiong, Heng, Xu, Qinying, Xu, Yanxun, Xue, Hong, Yachida, Shinichi, Yakneen, Sergei, Yamaguchi, Rui, Yamaguchi, Takafumi N, Yamamoto, Masakazu, Yamamoto, Shogo, Yamaue, Hiroki, Yang, Fan, Yang, Huanming, Yang, Jean Y, Yang, Liming, Yang, Lixing, Yang, Shanlin, Yang, Tsun-Po, Yang, Yang, Yao, Xiaotong, Yaspo, Marie-Laure, Yates, Lucy, Yau, Christina, Ye, Chen, Ye, Kai, Yellapantula, Venkata D, Yoon, Christopher J, Yoon, Sung-Soo, Yousif, Fouad, Yu, Jun, Yu, Kaixian, Yu, Willie, Yu, Yingyan, Yuan, Yuan, Yuen, Denis, Yung, Christina K, Zaikova, Olga, Zamora, Jorge, Zapatka, Marc, Zenklusen, Jean C, Zenz, Thorsten, Zeps, Nikolajs, Zhang, Cheng-Zhong, Zhang, Fan, Zhang, Hailei, Zhang, Hongwei, Zhang, Hongxin, Zhang, Jiashan, Zhang, Jing, Zhang, Xiuqing, Zhang, Xuanping, Zhang, Yan, Zhang, Zemin, Zhao, Zhongming, Zheng, Liangtao, Zheng, Xiuqing, Zhou, Wanding, Zhou, Yong, Zhu, Bin, Zhu, Hongtu, Zhu, Jingchun, Zhu, Shida, Zou, Lihua, Zou, Xueqing, deFazio, Anna, van As, Nicholas, van Deurzen, Carolien HM, van de Vijver, Marc J, Veer, L van’t, and von Mering, Christian
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA.
- Published
- 2023
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3. Combined burden and functional impact tests for cancer driver discovery using DriverPower
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
The discovery of driver mutations is one of the key motivations for cancer genome sequencing. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we describe DriverPower, a software package that uses mutational burden and functional impact evidence to identify driver mutations in coding and non-coding sites within cancer whole genomes. Using a total of 1373 genomic features derived from public sources, DriverPower’s background mutation model explains up to 93% of the regional variance in the mutation rate across multiple tumour types. By incorporating functional impact scores, we are able to further increase the accuracy of driver discovery. Testing across a collection of 2583 cancer genomes from the PCAWG project, DriverPower identifies 217 coding and 95 non-coding driver candidates. Comparing to six published methods used by the PCAWG Drivers and Functional Interpretation Working Group, DriverPower has the highest F1 score for both coding and non-coding driver discovery. This demonstrates that DriverPower is an effective framework for computational driver discovery.
- Published
- 2023
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4. Integrative pathway enrichment analysis of multivariate omics data
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Vijver, Marc J, and Veer, L van’t
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Multi-omics datasets represent distinct aspects of the central dogma of molecular biology. Such high-dimensional molecular profiles pose challenges to data interpretation and hypothesis generation. ActivePathways is an integrative method that discovers significantly enriched pathways across multiple datasets using statistical data fusion, rationalizes contributing evidence and highlights associated genes. As part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumor types, we integrated genes with coding and non-coding mutations and revealed frequently mutated pathways and additional cancer genes with infrequent mutations. We also analyzed prognostic molecular pathways by integrating genomic and transcriptomic features of 1780 breast cancers and highlighted associations with immune response and anti-apoptotic signaling. Integration of ChIP-seq and RNA-seq data for master regulators of the Hippo pathway across normal human tissues identified processes of tissue regeneration and stem cell regulation. ActivePathways is a versatile method that improves systems-level understanding of cellular organization in health and disease through integration of multiple molecular datasets and pathway annotations.
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- 2023
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5. Pathway and network analysis of more than 2500 whole cancer genomes
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer across 38 tumor types, we perform multi-faceted pathway and network analyses of non-coding mutations across 2583 whole cancer genomes from 27 tumor types compiled by the ICGC/TCGA PCAWG project that was motivated by the success of pathway and network analyses in prioritizing rare mutations in protein-coding genes. While few non-coding genomic elements are recurrently mutated in this cohort, we identify 93 genes harboring non-coding mutations that cluster into several modules of interacting proteins. Among these are promoter mutations associated with reduced mRNA expression in TP53, TLE4, and TCF4. We find that biological processes had variable proportions of coding and non-coding mutations, with chromatin remodeling and proliferation pathways altered primarily by coding mutations, while developmental pathways, including Wnt and Notch, altered by both coding and non-coding mutations. RNA splicing is primarily altered by non-coding mutations in this cohort, and samples containing non-coding mutations in well-known RNA splicing factors exhibit similar gene expression signatures as samples with coding mutations in these genes. These analyses contribute a new repertoire of possible cancer genes and mechanisms that are altered by non-coding mutations and offer insights into additional cancer vulnerabilities that can be investigated for potential therapeutic treatments.
- Published
- 2023
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6. Divergent mutational processes distinguish hypoxic and normoxic tumours
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Bhandari, Vinayak, Li, Constance H, Bristow, Robert G, Boutros, Paul C, Aaltonen, Lauri A, Abascal, Federico, Abeshouse, Adam, Aburatani, Hiroyuki, Adams, David J, Agrawal, Nishant, Ahn, Keun Soo, Ahn, Sung-Min, Aikata, Hiroshi, Akbani, Rehan, Akdemir, Kadir C, Al-Ahmadie, Hikmat, Al-Sedairy, Sultan T, Al-Shahrour, Fatima, Alawi, Malik, Albert, Monique, Aldape, Kenneth, Alexandrov, Ludmil B, Ally, Adrian, Alsop, Kathryn, Alvarez, Eva G, Amary, Fernanda, Amin, Samirkumar B, Aminou, Brice, Ammerpohl, Ole, Anderson, Matthew J, Ang, Yeng, Antonello, Davide, Anur, Pavana, Aparicio, Samuel, Appelbaum, Elizabeth L, Arai, Yasuhito, Aretz, Axel, Arihiro, Koji, Ariizumi, Shun-ichi, Armenia, Joshua, Arnould, Laurent, Asa, Sylvia, Assenov, Yassen, Atwal, Gurnit, Aukema, Sietse, Auman, J Todd, Aure, Miriam RR, Awadalla, Philip, Aymerich, Marta, Bader, Gary D, Baez-Ortega, Adrian, Bailey, Matthew H, Bailey, Peter J, Balasundaram, Miruna, Balu, Saianand, Bandopadhayay, Pratiti, Banks, Rosamonde E, 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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning 27 cancer types. Elevated hypoxia associates with increased mutational load across cancer types, irrespective of underlying mutational class. The proportion of mutations attributed to several mutational signatures of unknown aetiology directly associates with the level of hypoxia, suggesting underlying mutational processes for these signatures. At the gene level, driver mutations in TP53, MYC and PTEN are enriched in hypoxic tumours, and mutations in PTEN interact with hypoxia to direct tumour evolutionary trajectories. Overall, hypoxia plays a critical role in shaping the genomic and evolutionary landscapes of cancer.
- Published
- 2023
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7. Genomic footprints of activated telomere maintenance mechanisms in cancer
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Okusaka, Takuji, Omberg, Larsson, Ong, Choon Kiat, Ott, German, Ouellette, BF Francis, P’ng, Christine, Paczkowska, Marta, Paiella, Salvatore, Pairojkul, Chawalit, Pajic, Marina, Pan-Hammarström, Qiang, Papaemmanuil, Elli, Papatheodorou, Irene, Paramasivam, Nagarajan, Park, Ji Wan, Park, Joong-Won, Park, Keunchil, Park, Kiejung, Parker, Joel S, Parsons, Simon L, Pass, Harvey, Pasternack, Danielle, Pastore, Alessandro, Patch, Ann-Marie, Pauporté, Iris, Pea, Antonio, Pedamallu, Chandra Sekhar, Pedersen, Jakob Skou, Pederzoli, Paolo, Peifer, Martin, Pennell, Nathan A, Perou, Charles M, Perry, Marc D, Petersen, Gloria M, Peto, Myron, Petrelli, Nicholas, Petryszak, Robert, Pfister, Stefan M, Phillips, Mark, Pich, Oriol, Pickett, Hilda A, Pihl, Todd D, Pillay, Nischalan, Pinder, Sarah, Pinese, Mark, Pinho, Andreia V, Pitkänen, Esa, Pivot, Xavier, Piñeiro-Yáñez, Elena, Planko, Laura, Plass, Christoph, Polak, Paz, Pons, Tirso, Popescu, Irinel, Potapova, Olga, Prasad, Aparna, Preston, Shaun R, Prinz, Manuel, Pritchard, Antonia L, Prokopec, Stephenie D, Provenzano, Elena, Puente, Xose S, Puig, Sonia, Pulido-Tamayo, Sergio, Pupo, Gulietta M, Purdie, Colin A, Quinn, Michael C, Rabionet, Raquel, Rader, Janet S, Radlwimmer, Bernhard, Radovic, Petar, Raeder, Benjamin, Raine, Keiran M, Ramakrishna, Manasa, Ramakrishnan, Kamna, Ramalingam, Suresh, Raphael, Benjamin J, Rathmell, W Kimryn, Rausch, Tobias, Reifenberger, Guido, Reimand, Jüri, Reis-Filho, Jorge, Reuter, Victor, Reyes-Salazar, Iker, Reyna, Matthew A, Reynolds, Sheila M, Rheinbay, Esther, Riazalhosseini, Yasser, Richardson, Andrea L, Richter, Julia, Ringel, Matthew, Ringnér, Markus, Rino, Yasushi, Roach, Jeffrey, Roberts, Lewis R, Robertson, A Gordon, Robertson, Alan J, Rodriguez, Javier Bartolomé, Rodríguez-González, F Germán, Roehrl, Michael HA, Rohde, Marius, Rokutan, Hirofumi, Romieu, Gilles, Rooman, Ilse, Roques, Tom, Rosebrock, Daniel, Rosenberg, Mara, Rosenstiel, Philip C, Rosenwald, Andreas, Rowe, Edward W, Royo, Romina, Rozen, Steven G, Rubanova, Yulia, Rubin, Mark A, Rubio-Perez, Carlota, Rudneva, Vasilisa A, Rusev, Borislav C, Ruzzenente, Andrea, Rätsch, Gunnar, Sabarinathan, Radhakrishnan, Sabelnykova, Veronica Y, Sadeghi, Sara, Sahinalp, S Cenk, Saini, Natalie, Saito-Adachi, Mihoko, Saksena, Gordon, Salcedo, Adriana, Salgado, Roberto, Salichos, Leonidas, Sallari, Richard, Saller, Charles, Salvia, Roberto, Sam, Michelle, Samra, Jaswinder S, Sanchez-Vega, Francisco, Sander, Chris, Sanders, Grant, Sarin, Rajiv, Sarrafi, Iman, Sasaki-Oku, Aya, Sauer, Torill, Sauter, Guido, Saw, Robyn PM, Scardoni, Maria, Scarlett, Christopher J, Scarpa, Aldo, Scelo, Ghislaine, Schadendorf, Dirk, Schein, Jacqueline E, Schilhabel, Markus B, Schlomm, Thorsten, Schmidt, Heather K, Schramm, Sarah-Jane, Schreiber, Stefan, Schultz, Nikolaus, Schwarz, Roland F, Scolyer, Richard A, Scott, David, Seethala, Raja, Segre, Ayellet V, Selander, Iris, Semple, Colin A, Senbabaoglu, Yasin, Sengupta, Subhajit, Sereni, Elisabetta, Serra, Stefano, Sgroi, Dennis C, Shah, Nimish C, Shahabi, Sagedeh, Shang, Catherine A, Shang, Ping, Shapira, Ofer, Shelton, Troy, Shen, Ciyue, Shen, Hui, Shepherd, Rebecca, Shi, Ruian, Shi, Yan, Shiah, Yu-Jia, Shibata, Tatsuhiro, Shih, Juliann, Shimizu, Eigo, Shimizu, Kiyo, Shin, Seung Jun, Shiraishi, Yuichi, Shmaya, Tal, Shmulevich, Ilya, Shorser, Solomon I, Short, Charles, Shrestha, Raunak, Shringarpure, Suyash S, Shriver, Craig, Shuai, Shimin, Siebert, Reiner, Sieuwerts, Anieta M, Signoretti, Sabina, Sikora, Katarzyna O, Simbolo, Michele, Simon, Ronald, Simons, Janae V, Simpson, Jared T, Simpson, Peter T, Singer, Samuel, Sinnott-Armstrong, Nasa, Sipahimalani, Payal, Skelly, Tara J, Smid, Marcel, Smith, Jaclyn, Smith-McCune, Karen, Socci, Nicholas D, Sofia, Heidi J, Soloway, Matthew G, Song, Lei, Sood, Anil K, Sothi, Sharmila, Sotiriou, Christos, Soulette, Cameron M, Span, Paul N, Spellman, Paul T, Sperandio, Nicola, Spillane, Andrew J, Spiro, Oliver, Spring, Jonathan, Staaf, Johan, Stadler, Peter F, Staib, Peter, Stark, Stefan G, Stebbings, Lucy, Stefánsson, Ólafur Andri, Stegle, Oliver, Stein, Lincoln D, Stenhouse, Alasdair, Stilgenbauer, Stephan, Stobbe, Miranda D, Stratton, Michael R, Stretch, Jonathan R, Struck, Adam J, Stuart, Joshua M, Stunnenberg, Henk G, Su, Hong, Su, Xiaoping, Sun, Ren X, Sungalee, Stephanie, Susak, Hana, Suzuki, Akihiro, Sweep, Fred, Szczepanowski, Monika, Sültmann, Holger, Yugawa, Takashi, Tam, Angela, Tamborero, David, Tan, Benita Kiat Tee, Tan, Donghui, Tan, Patrick, Tanaka, Hiroko, Taniguchi, Hirokazu, Tanskanen, Tomas J, Tarabichi, Maxime, Tarnuzzer, Roy, Tarpey, Patrick, Taschuk, Morgan L, Tatsuno, Kenji, Tavaré, Simon, Taylor, Darrin F, Taylor-Weiner, Amaro, Teague, Jon W, Teh, Bin Tean, Tembe, Varsha, Temes, Javier, Thai, Kevin, Thayer, Sarah P, Thiessen, Nina, Thomas, Gilles, Thomas, Sarah, Thompson, Alan, Thompson, Alastair M, Thompson, John FF, Thompson, R Houston, Thorne, Heather, Thorne, Leigh B, Thorogood, Adrian, Tiao, Grace, Tijanic, Nebojsa, Timms, Lee E, Tirabosco, Roberto, Tojo, Marta, Tommasi, Stefania, Toon, Christopher W, Toprak, Umut H, Tortora, Giampaolo, Tost, Jörg, Totoki, Yasushi, Townend, David, Traficante, Nadia, Treilleux, Isabelle, Trotta, Jean-Rémi, Trümper, Lorenz HP, Tsao, Ming, Tsunoda, Tatsuhiko, Tucker, Olga, Turkington, Richard, Turner, Daniel J, Tutt, Andrew, Ueno, Masaki, Ueno, Naoto T, Umbricht, Christopher, Umer, Husen M, Underwood, Timothy J, Urban, Lara, Urushidate, Tomoko, Ushiku, Tetsuo, Uusküla-Reimand, Liis, Valencia, Alfonso, Van Den Berg, David J, Van Laere, Steven, Van Loo, Peter, Van Meir, Erwin G, Van den Eynden, Gert G, Van der Kwast, Theodorus, Vasudev, Naveen, Vazquez, Miguel, Vedururu, Ravikiran, Veluvolu, Umadevi, Vembu, Shankar, Verbeke, Lieven PC, Vermeulen, Peter, Verrill, Clare, Viari, Alain, Vicente, David, Vicentini, Caterina, VijayRaghavan, K, Viksna, Juris, Vilain, Ricardo E, Vincent-Salomon, Anne, Visakorpi, Tapio, Voet, Douglas, Vyas, Paresh, Vázquez-García, Ignacio, Waddell, Nick M, Wadelius, Claes, Wadi, Lina, Wagener, Rabea, Wang, Jian, Wang, Jiayin, Wang, Linghua, Wang, Qi, Wang, Wenyi, Wang, Yumeng, Wang, Zhining, Waring, Paul M, Warnatz, Hans-Jörg, Warrell, Jonathan, Warren, Anne Y, Waszak, Sebastian M, Wedge, David C, Weichenhan, Dieter, Weinberger, Paul, Weinstein, John N, Weisenberger, Daniel J, Welch, Ian, Wendl, Michael C, Werner, Johannes, Whalley, Justin P, Wheeler, David A, Whitaker, Hayley C, Wigle, Dennis, Wilkerson, Matthew D, Williams, Ashley, Wilmott, James S, Wilson, Gavin W, Wilson, Julie M, Wilson, Richard K, Winterhoff, Boris, Wintersinger, Jeffrey A, Wiznerowicz, Maciej, Wolf, Stephan, Wong, Bernice H, Wong, Tina, Wong, Winghing, Woo, Youngchoon, Wood, Scott, Wouters, Bradly G, Wright, Adam J, Wright, Derek W, Wright, Mark H, Wu, Chin-Lee, Wu, Dai-Ying, Wu, Guanming, Wu, Jianmin, Wu, Kui, Wu, Yang, Wu, Zhenggang, Xi, Liu, Xia, Tian, Xiang, Qian, Xiao, Xiao, Xing, Rui, Xiong, Heng, Xu, Qinying, Xu, Yanxun, Xue, Hong, Yachida, Shinichi, Yakneen, Sergei, Yamaguchi, Rui, Yamaguchi, Takafumi N, Yamamoto, Masakazu, Yamamoto, Shogo, Yamaue, Hiroki, Yang, Fan, Yang, Huanming, Yang, Jean Y, Yang, Liming, Yang, Shanlin, Yang, Tsun-Po, Yang, Yang, Yaspo, Marie-Laure, Yates, Lucy, Yau, Christina, Ye, Chen, Ye, Kai, Yellapantula, Venkata D, Yoon, Christopher J, Yousif, Fouad, Yu, Jun, Yu, Kaixian, Yu, Willie, Yu, Yingyan, Yuan, Ke, Yuan, Yuan, Yuen, Denis, Yung, Christina K, Zaikova, Olga, Zapatka, Marc, Zenklusen, Jean C, Zenz, Thorsten, Zeps, Nikolajs, Zhang, Fan, Zhang, Hailei, Zhang, Hongwei, Zhang, Hongxin, Zhang, Jiashan, Zhang, Jing, Zhang, Junjun, Zhang, Xiuqing, Zhang, Xuanping, Zhang, Yan, Zhang, Zemin, Zhao, Zhongming, Zheng, Liangtao, Zheng, Xiuqing, Zhou, Wanding, Zhou, Yong, Zhu, Bin, Zhu, Hongtu, Zhu, Jingchun, Zhu, Shida, Zou, Lihua, Zou, Xueqing, deFazio, Anna, van As, Nicholas, van Deurzen, Carolien HM, van de Vijver, Marc J, Veer, L van’t, and von Mering, Christian
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Human Biology & Physiology ,Ecology,Evolution & Ethology ,Tumour Biology ,Genetics & Genomics ,Structural Biology & Biophysics ,Computational & Systems Biology - Abstract
Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we dissect whole-genome sequencing data of over 2500 matched tumor-control samples from 36 different tumor types aggregated within the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium to characterize the genomic footprints of these mechanisms. While the telomere content of tumors with ATRX or DAXX mutations (ATRX/DAXXtrunc) is increased, tumors with TERT modifications show a moderate decrease of telomere content. One quarter of all tumor samples contain somatic integrations of telomeric sequences into non-telomeric DNA. This fraction is increased to 80% prevalence in ATRX/DAXXtrunc tumors, which carry an aberrant telomere variant repeat (TVR) distribution as another genomic marker. The latter feature includes enrichment or depletion of the previously undescribed singleton TVRs TTCGGG and TTTGGG, respectively. Our systematic analysis provides new insight into the recurrent genomic alterations associated with telomere maintenance mechanisms in cancer.
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- 2023
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8. Queratoquistes odontogénicos maxilares en paciente con síndrome de Gorlin. Descripción de un caso y revisión de la literatura
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Andrés González F., Ignacio Sanhueza T., Pamela Elyette Benítez A., Sheila Huerga M., and Alba Larrea R.
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General Medicine - Published
- 2021
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9. Condrosarcoma del hueso hioides: a propósito de un caso
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Ignacio Sanhueza T., Andrés González F., and Diego Regalado B.
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cuello ,sarcoma ,Condrosarcoma ,hioides ,General Medicine ,cabeza - Abstract
Resumen Los condrosarcomas son cánceres realmente infrecuentes en cabeza y cuello, y más aún en el hueso hioides. Por lo general, son neoplasias que debutan como una masa cervical sin otra sintomatología. Su diagnóstico requiere de estudios de imagen y su tratamiento es fundamentalmente quirúrgico. Comentamos el caso de un paciente de 57 años, desde el diagnóstico de la lesión hasta su tratamiento y seguimiento, y una revisión bibliográfica de esta patología.
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- 2021
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10. Programa de Formación para Emprendedores desde la formación de posgrado en la Península de Paraguaná-Venezuela
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Coelho, H. and Marín-González, F.
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innovación ,formación ,estrategias de desarrollo local ,procesos de cooperación ,Emprendimiento - Abstract
El desarrollo socioeconómico de una localidad está directamente relacionado con sus potencialidades naturales y los actores sociales que interactúan en ella. En la medida que se establezcan redes de cooperación intersectoriales, aumentan las posibilidades de optimizar la calidad de vida de sus habitantes. Desde este referente el objetivo del artículo es presentar el diseño de un programa de formación para emprendedores en el ámbito de la relación universidad – empresa, resultado de un proyecto de intervención social; el componente metodológico se fundamenta en la concepción de estrategias de desarrollo local, contextualizadas en la interfaz relacional entre un programa de posgrado de una universidad pública venezolana y el sector productivo, a través de la Cámara de Industria y Comercio. El resultado evidencia la concepción y diseño de un Programa de Formación para Emprendedores: Emprender para Triunfar, cuya validación ocurre con la participación de los actores comunitarios y en correspondencia con los rasgos que definen su perfil. Entre las principales conclusiones resalta la pertinencia de aplicar estrategias orientadas al crecimiento personal y profesional de individuos motivados a la innovación y emprendimiento en materia de negocios.
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- 2022
11. Plateau Tibial Fractures are Associated with High Rates of Major Ligaments Ruptures
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Manuel Mosquera, Juan Ricardo Gil, David Portilla, Juan Manuel Mosquera, Yessica Paola González F, and Andrés Felipe Vence
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High rate ,geography ,Plateau ,geography.geographical_feature_category ,General Medicine ,Anatomy ,Geology - Published
- 2021
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12. Pasture feeding strategy and milk fatty acid profile in small-scale dairy systems
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Plata-Reyes, D. A., Juárez-Dávila, L. E., ERNESTO MORALES-ALMARAZ, López-González, F., Flores-Calvete, G., and Arriaga-Jordán, C. M.
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General Veterinary ,Animal Science and Zoology - Abstract
The effect of the pasture feeding strategy on the milk fatty acid profile of lactating cows in small-scale dairy farms was evaluated. Ten farms participated in the study, five farms grazed pastures a minimum of 8.0 h/d, and five were fed cut herbage. Supplementary feeds were similar. Results were analysed with Student “t” test. There were no statistical differences when fatty acids were grouped by chain length, or in the proportion of saturated fatty acids (SFA) or monounsaturated fatty acids (MUFA), but there were differences for polyunsaturated fatty acids (PUFA). Alpha-Linolenic acid (C18:3 n-3) was significantly higher in milk of grazing cows than in cows fed cut herbage. There were no differences in atherogenicity index nor in the Δ9 desaturase activity between pasture management strategies. In conclusion, grazing pastures results in milk with a more beneficial lipid profile for human health.
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- 2021
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13. Bilinear optimal control for weak solutions of the Keller-Segel logistic model in $2D$ domains
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Silva, P. Braz e, Guillén-González, F., Perusato, C. F., and Rodríguez-Bellido, M. A.
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Mathematics - Analysis of PDEs ,Optimization and Control (math.OC) ,FOS: Mathematics ,Mathematics - Optimization and Control ,Analysis of PDEs (math.AP) ,35K51, 35Q92, 49J20, 49K20 - Abstract
An optimal control problem associated to the Keller-Segel with logistic reaction system will be studied in $2D$ domains. The control acts in a bilinear form only in the chemical equation. The existence of optimal control and a necessary optimality system are deduced. The main novelty is that control can be rather singular and the state (cell density $u$ and the chemical concentration $v$) remains only in a weak setting, which is not usual in the literature to solve optimal control problems subject to chemotaxis models (see e.g. Guill\'en-Gonz\'alez et al. ESAIM Control Optim. Calc. Var. 26 (2020), Paper No. 29, 21 pp)., Comment: 22 pages. arXiv admin note: text overlap with arXiv:1808.09294
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- 2022
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14. Development and validation of a nomogram to predict kidney survival at baseline in patients with C3 glomerulopathy
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Caravaca-Fontan, Fernando, Rivero, M., Cavero, T., Díaz Encarnación, Montserrat Mercedes, Cabello, V., Ariceta, G., Quintana, Luis F, Marco, H., Barros, X., Ramos, N., Rodríguez-Mendiola, N., Cruz, S., Fernández-Juárez, G., Rodríguez, A., De José, A.P., Rabasco, C., Rodado, R., Fernández, L., Pérez-Gómez, Maria Vanessa, Ávila, A., Bravo, L., Espinosa, N., Allende, N., De La Nieta, M.D.S., Rodríguez, E., Olea, T., Melgosa, M., Huerta, A., Miquel, R., Mon, C., Fraga, Gloria, De Lorenzo, A., Draibe, J., González, F., Shabaka, A., López-Rubio, M.E., Fenollosa, M.Á., Martín-Penagos, L., Da Silva, I., Alonso Titos, J., De Córdoba, S.R., De Jorge, E.G., Praga, M., Universitat Autònoma de Barcelona, Instituto de Salud Carlos III, Red Española de Investigación Renal, Comunidad de Madrid, Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando, Cavero, Teresa, Díaz-Encarnación, Montserrat M., Ariceta, Gema, Quintana, Luis F., Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Fernández-Juárez, Gema, Pérez de José, Ana, Pérez Gómez, Vanessa, Allende, Natalia, Sánchez de la Nieta, María Dolores, Olea, Teresa, Melgosa, Marta, Huerta, Ana, Mon, Carmen, de Lorenzo, Alberto, Draibe, Juliana, González, Fayna, Shabaka, Amir, Martín-Penagos, L., Rodríguez de Córdoba, Santiago, Goicoechea de Jorge, Elena, Praga, Manuel, and Universidad de Cantabria
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nomogram ,Transplantation ,Nephrology ,Calibration ,Discrimination ,Glomerulopathy ,Kidney failure ,C3 glomerulopathy ,calibration ,Nomogram ,discrimination ,kidney failure - Abstract
10 p.-4 fig.-2 tab. 1 graph. abst., Background: C3 glomerulopathy is a rare and heterogeneous complement-driven disease. It is often challenging to accurately predict in clinical practice the individual kidney prognosis at baseline. We herein sought to develop and validate a prognostic nomogram to predict long-term kidney survival., Methods: We conducted a retrospective, multicenter observational cohort study in 35 nephrology departments belonging to the Spanish Group for the Study of Glomerular Diseases. The dataset was randomly divided into a training group (n = 87) and a validation group (n = 28). The least absolute shrinkage and selection operator (LASSO) regression was used to screen the main predictors of kidney outcome and to build the nomogram. The accuracy of the nomogram was assessed by discrimination and risk calibration in the training and validation sets., Results: The study group comprised 115 patients, of whom 46 (40%) reached kidney failure in a median follow-up of 49 months (range 24–112). No significant differences were observed in baseline estimated glomerular filtration rate (eGFR), proteinuria or total chronicity score of kidney biopsies, between patients in the training versus those in the validation set. The selected variables by LASSO were eGFR, proteinuria and total chronicity score. Based on a Cox model, a nomogram was developed for the prediction of kidney survival at 1, 2, 5 and 10 years from diagnosis. The C-index of the nomogram was 0.860 (95% confidence interval 0.834–0.887) and calibration plots showed optimal agreement between predicted and observed outcomes., Conclusions: We constructed and validated a practical nomogram with good discrimination and calibration to predict the risk of kidney failure in C3 glomerulopathy patients at 1, 2, 5 and 10 years., Work on this study was supported by the Instituto de Salud Carlos III / Fondo Europeo de Desarrollo Regional (ISCIII/FEDER; grants PI16/01685 and PI19/1624) and Red de Investigación Renal (RD12/0021/0029; to M.P.) and the Autonomous Region of Madrid (S2017/BMD-3673; to M.P.). S.R.d.C. is supported by the Ministerio de Economia y Competitividad (grant PID2019-104912RB-I00) and the Autonomous Region of Madrid (grant S2017/BMD-3673).
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- 2022
15. The European Solar Telescope
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Quintero Noda, C., Schlichenmaier, R., Bellot Rubio, L. R., Löfdahl, M. G., Khomenko, E., Jurčák, J., Leenaarts, J., Kuckein, C., González Manrique, S. J., Gunár, S., Nelson, C. J., de la Cruz Rodríguez, J., Tziotziou, K., Tsiropoula, G., Aulanier, G., Aboudarham, J., Allegri, D., Alsina Ballester, E., Amans, J. P., Asensio Ramos, A., Bailén, F. J., Balaguer, M., Baldini, V., Balthasar, H., Barata, T., Barczynski, K., Barreto Cabrera, M., Baur, A., Béchet, C., Beck, C., Belío-Asín, M., Bello-González, N., Belluzzi, L., Bentley, R. D., Berdyugina, S. V., Berghmans, D., Berlicki, A., Berrilli, F., Berkefeld, T., Bettonvil, F., Bianda, M., Bienes Pérez, J., Bonaque-González, S., Brajša, R., Bommier, V., Bourdin, P. -A., Burgos Martín, J., Calchetti, D., Calcines, A., Calvo Tovar, J., Campbell, R. J., Carballo-Martín, Y., Carbone, V., Carlin, E. S., Carlsson, M., Castro López, J., Cavaller, L., Cavallini, F., Cauzzi, G., Cecconi, M., Chulani, H. M., Cirami, R., Consolini, G., Coretti, I., Cosentino, R., Cózar-Castellano, J., Dalmasse, K., Danilovic, S., de Juan Ovelar, M., del Moro, D., del Pino Alemán, T., del Toro Iniesta, J. C., Denker, C., Dhara, S. K., Di Marcantonio, P., Díaz Baso, C. J., Diercke, A., Dineva, E., Díaz-García, J. J., Doerr, H. -P., Doyle, G., Erdelyi, R., Ermolli, I., Escobar Rodríguez, A., Esteban Pozuelo, S., Faurobert, M., Felipe, T., Feller, A., Feijoo Amoedo, N., Femenía Castellá, B., Fernandes, J., Ferro Rodríguez, I., Figueroa, I., Fletcher, L., Franco Ordovas, A., Gafeira, R., Gardenghi, R., Gelly, B., Giorgi, F., Gisler, D., Giovannelli, L., González, F., González, J. B., González-Cava, J. M., González García, M., Gömöry, P., Gracia, F., Grauf, B., Greco, V., Grivel, C., Guerreiro, N., Guglielmino, S. L., Hammerschlag, R., Hanslmeier, A., Hansteen, V., Heinzel, P., Hernández-Delgado, A., Hernández Suárez, E., Hidalgo, S. L., Hill, F., Hizberger, J., Hofmeister, S., Jägers, A., Janett, G., Jarolim, R., Jess, D., Jiménez Mejías, D., Jolissaint, L., Kamlah, R., Kapitán, J., Kašparová, J., Keller, C. U., Kentischer, T., Kiselman, D., Kleint, L., Klvana, M., Kontogiannis, I., Krishnappa, N., Kučera, A., Labrosse, N., Lagg, A., Landi Degl'Innocenti, E., Langlois, M., Lafon, M., Laforgue, D., Le Men, C., Lepori, B., Lepreti, F., Lindberg, B., Lilje, P. B., López Ariste, A., López Fernández, V. A., López Jiménez, A. C., López López, R., Manso Sainz, R., Marassi, A., Marco de la Rosa, J., Marino, J., Marrero, J., Martín, A., Martín Gálvez, A., Martín Hernando, Y., Masciadri, E., Martínez González, M., Matta-Gómez, A., Mato, A., Mathioudakis, M., Matthews, S., Mein, P., Merlos García, F., Moity, J., Montilla, I., Molinaro, M., Molodij, G., Montoya, L. M., Munari, M., Murabito, M., Núñez Cagigal, M., Oliviero, M., Orozco Suárez, D., Ortiz, A., Padilla-Hernández, C., Paéz Mañá, E., Paletou, F., Pancorbo, J., Pastor Cañedo, A., Pastor Yabar, A., Peat, A. W., Pedichini, F., Peixinho, N., Peñate, J., Pérez de Taoro, A., Peter, H., Petrovay, K., Piazzesi, R., Pietropaolo, E., Pleier, O., Poedts, S., Pötzi, W., Podladchikova, T., Prieto, G., Quintero Nehrkorn, J., Ramelli, R., Ramos Sapena, Y., Rasilla, J. L., Reardon, K., Rebolo, R., Regalado Olivares, S., Reyes García-Talavera, M., Riethmüller, T. L., Rimmele, T., Rodríguez Delgado, H., Rodríguez González, N., Rodríguez-Losada, J. A., Rodríguez Ramos, L. F., Romano, P., Roth, M., Rouppe van der Voort, L., Rudawy, P., Ruiz de Galarreta, C., Rybák, J., Salvade, A., Sánchez-Capuchino, J., Sánchez Rodríguez, M. L., Sangiorgi, M., Sayède, F., Scharmer, G., Scheiffelen, T., Schmidt, W., Schmieder, B., Scirè, C., Scuderi, S., Siegel, B., Sigwarth, M., Simões, P. J. A., Snik, F., Sliepen, G., Sobotka, M., Socas-Navarro, H., Sola La Serna, P., Solanki, S. K., Soler Trujillo, M., Soltau, D., Sordini, A., Sosa Méndez, A., Stangalini, M., Steiner, O., Stenflo, J. O., Štěpán, J., Strassmeier, K. G., Sudar, D., Suematsu, Y., Sütterlin, P., Tallon, M., Temmer, M., Tenegi, F., Tritschler, A., Trujillo Bueno, J., Turchi, A., Utz, D., van Harten, G., van Noort, M., van Werkhoven, T., Vansintjan, R., Vaz Cedillo, J. J., Vega Reyes, N., Verma, M., Veronig, A. M., Viavattene, G., Vitas, N., Vögler, A., von der Lühe, O., Volkmer, R., Waldmann, T. A., Walton, D., Wisniewska, A., Zeman, J., Zeuner, F., Zhang, L. Q., Zuccarello, F., Collados, M., Instituto de Astrofísica de Canarias, Leibniz-Institut für Sonnenphysik, CSIC - Institute of Astrophysics of Andalusia, Stockholm University, Czech Academy of Sciences, Queen's University Belfast, National Observatory of Athens, UMR7095, Observatoire de Paris, University of Applied Sciences and Arts of Southern Switzerland, Osservatorio Astronomico di Trieste, Leibniz Institute for Astrophysics Potsdam, Universidade de Coimbra, University of Applied Sciences Western Switzerland, Pontificia Universidad Católica de Chile, National Solar Observatory, Università della Svizzera italiana, University College London, Royal Observatory of Belgium, University of Rome Tor Vergata, Leiden University, University of Zagreb, University of Graz, Department of Computer Science, Chinese Academy of Sciences, Aalto-yliopisto, Aalto University, Ministerio de Ciencia e Innovación (España), European Commission, European Research Council, Laboratoire de Physique des Plasmas (LPP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Observatoire de la Côte d'Azur (OCA), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Astrophysique de Lyon (CRAL), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
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chromosphere ,Astrophysics - instrumentation and methods for astrophysics ,SCATTERING POLARIZATION ,Sun - chromosphere ,FOS: Physical sciences ,chromosphere [Sun] ,Astronomy & Astrophysics ,magnetic fields ,Instrumentation: polarimeters ,CA II 8542 ,Astrophysics - solar and stellar astrophysics ,adaptive optics ,ADAPTIVE OPTICS SYSTEM ,RADIATION-FIELD LIMIT ,MAGNETIC-FLUX EMERGENCE ,telescopes – Sun: magnetic fields – Sun: chromosphere – instrumentation: adaptive optics – instrumentation: polarimeters ,Sun: magnetic fields ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,Solar and Stellar Astrophysics (astro-ph.SR) ,instrumentation ,Science & Technology ,polarimeters [Instrumentation] ,[SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph] ,Instrumentation: adaptive optics ,polarimeters ,ACTIVE-REGION FILAMENT ,Sun: chromosphere ,Sun ,Astronomy and Astrophysics ,Instrumentation: -polarimeters ,adaptive optics [Instrumentation] ,Sun - magnetic fields ,QUIET-SUN ,magnetic fields [Sun] ,Space and Planetary Science ,[SDU]Sciences of the Universe [physics] ,Physical Sciences ,ALFVEN WAVES ,HIGH-RESOLUTION OBSERVATIONS ,Instrumentation - adaptive optics ,MAGNETOHYDRODYNAMIC WAVES ,Telescopes - Abstract
Full list of authors: Noda, C. Quintero; Schlichenmaier, R.; Bellot Rubio, L. R.; Lofdahl, M. G.; Khomenko, E.; Leenaarts, J.; Kuckein, C.; Gonzalez Manrique, S. J.; Gunar, S.; Nelson, C. J.; Rodriguez, J. de la Cruz; Tziotziou, K.; Tsiropoula, G.; Aulanier, G.; Aboudarham, J.; Allegri, D.; Alsina Ballester, E.; Amans, J. P.; Asensio Ramos, A.; Bailen, F. J.; Balaguer, M.; Baldini, V; Balthasar, H.; Barata, T.; Barczynski, K.; Barreto Cabrera, M.; Baur, A.; Bechet, C.; Beck, C.; Belio-Asin, M.; Bello-Gonzalez, N.; Belluzzi, L.; Bentley, R. D.; Berdyugina, S., V; Berghmans, D.; Berlicki, A.; Berrilli, F.; Berkefeld, T.; Bettonvil, F.; Bianda, M.; Bienes Perez, J.; Bonaque-Gonzalez, S.; Brajsa, R.; Bommier, V; Bourdin, P-A; BurgosMartin, J.; Calchetti, D.; Calcines, A.; Calvo Tovar, J.; Campbell, R. J.; Carballo-Martin, Y.; Carbone, V; Carlin, E. S.; Carlsson, M.; Castro Lopez, J.; Cavaller, L.; Cavallini, F.; Cauzzi, G.; Cecconi, M.; Chulani, H. M.; Cirami, R.; Consolini, G.; Coretti, I; Cosentino, R.; Cozar-Castellano, J.; Dalmasse, K.; Danilovic, S.; Ovelar, M. De Juan; Del Moro, D.; del Pino Aleman, T.; del Toro Iniesta, J. C.; Denker, C.; Dhara, S. K.; Di Marcantonio, P.; Baso, C. J. Diaz; Diercke, A.; Dineva, E.; Diaz-Garcia, J. J.; Doerr, H-P; Doyle, G.; Erdelyi, R.; Ermolli, I; Escobar Rodriguez, A.; Esteban Pozuelo, S.; Faurobert, M.; Felipe, T.; Feller, A.; Feijoo Amoedo, N.; Femenia Castella, B.; Fernandes, J.; Ferro Rodriguez, I; Figueroa, I; Fletcher, L.; Franco Ordovas, A.; Gafeira, R.; Gardenghi, R.; Gelly, B.; Giorgi, F.; Gisler, D.; Giovannelli, L.; Gonzalez, F.; Gonzalez, J. B.; Gonzalez-Cava, J. M.; Gonzalez Garcia, M.; Gomory, P.; Gracia, F.; Grauf, B.; Greco, V; Grivel, C.; Guerreiro, N.; Guglielmino, S. L.; Hammerschlag, R.; Hanslmeier, A.; Hansteen, V; Heinzel, P.; Hernandez-Delgado, A.; Hernandez Suarez, E.; Hidalgo, S. L.; Hill, F.; Hizberger, J.; Hofmeister, S.; Jagers, A.; Janett, G.; Jarolim, R.; Jess, D.; Jimenez Mejias, D.; Jolissaint, L.; Kamlah, R.; Kapitan, J.; Kasparova, J.; Keller, C. U.; Kentischer, T.; Kiselman, D.; Kleint, L.; Klvana, M.; Kontogiannis, I; Krishnappa, N.; Labrosse, N.; Lagg, A.; Degl'Innocenti, E. Landi; Langlois, M.; Lafon, M.; Laforgue, D.; Le Men, C.; Lepori, B.; Lepreti, F.; Lindberg, B.; Lilje, P. B.; Ariste, A. Lopez; Lopez Fernandez, V. A.; Lopez Jimenez, A. C.; Lopez Lopez, R.; Sainz, R. Manso; Marassi, A.; Marco de la Rosa, J.; Marino, J.; Marrero, J.; Martin, A.; Martin Galvez, A.; Martin Hernando, Y.; Masciadri, E.; MartinezGonzalez, M.; Matta-Gomez, A.; Mato, A.; Mathioudakis, M.; Matthews, S.; Mein, P.; Merlos Garcia, F.; Moity, J.; Montilla, I; Molinaro, M.; Molodij, G.; Montoya, L. M.; Munari, M.; Murabito, M.; Nunez Cagigal, M.; Oliviero, M.; Orozco Suarez, D.; Ortiz, A.; Padilla-Hernandez, C.; Paez Mana, E.; Paletou, F.; Pancorbo, J.; Pastor Canedo, A.; Yabar, A. Pastor; Peat, A. W.; Pedichini, F.; Peixinho, N.; Penate, J.; Perez de Taoro, A.; Peter, H.; Petrovay, K.; Piazzesi, R.; Pietropaolo, E.; Pleier, O.; Poedts, S.; Potzi, W.; Podladchikova, T.; Prieto, G.; Quintero Nehrkorn, J.; Ramelli, R.; Ramos Sapena, Y.; Rasilla, J. L.; Reardon, K.; Rebolo, R.; Regalado Olivares, S.; Reyes Garcia-Talavera, M.; Riethmuller, T. L.; Rimmele, T.; Rodriguez Delgado, H.; Rodriguez Gonzalez, N.; Rodriguez-Losada, J. A.; Rodriguez Ramos, L. F.; Romano, P.; Roth, M.; vander Voort, L. Rouppe; Rudawy, P.; Ruiz de Galarreta, C.; Rybak, J.; Salvade, A.; Sanchez-Capuchino, J.; Sanchez Rodriguez, M. L.; Sangiorgi, M.; Sayede, F.; Scharmer, G.; Scheiffelen, T.; Schmidt, W.; Schmieder, B.; Scire, C.; Scuderi, S.; Siegel, B.; Sigwarth, M.; Simoes, P. J. A.; Snik, F.; Sliepen, G.; Sobotka, M.; Socas-Navarro, H.; Sola La Serna, P.; Solanki, S. K.; Soler Trujillo, M.; Soltau, D.; Sordini, A.; Sosa Mendez, A.; Stangalini, M.; Steiner, O.; Stenflo, J. O.; Stepan, J.; Strassmeier, K. G.; Sudar, D.; Suematsu, Y.; Sutterlin, P.; Tallon, M.; Temmer, M.; Tenegi, F.; Tritschler, A.; Trujillo Bueno, J.; Turchi, A.; Utz, D.; van Harten, G.; VanNoort, M.; van Werkhoven, T.; Vansintjan, R.; Vaz Cedillo, J. J.; Vega Reyes, N.; Verma, M.; Veronig, A. M.; Viavattene, G.; Vitas, N.; Vogler, A.; von der Luhe, O.; Volkmer, R.; Waldmann, T. A.; Walton, D.; Wisniewska, A.; Zeman, J.; Zeuner, F.; Zhang, L. Q.; Zuccarello, F.; Collados, M.--This is an Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Swedish 1m Solar Telescope, the German Vacuum Tower Telescope and GREGOR, the French Télescope Héliographique pour l’Étude du Magnétisme et des Instabilités Solaires, and the Dutch Open Telescope. With its 4.2 m primary mirror and an open configuration, EST will become the most powerful European ground-based facility to study the Sun in the coming decades in the visible and near-infrared bands. EST uses the most innovative technological advances: the first adaptive secondary mirror ever used in a solar telescope, a complex multi-conjugate adaptive optics with deformable mirrors that form part of the optical design in a natural way, a polarimetrically compensated telescope design that eliminates the complex temporal variation and wavelength dependence of the telescope Mueller matrix, and an instrument suite containing several (etalon-based) tunable imaging spectropolarimeters and several integral field unit spectropolarimeters. This publication summarises some fundamental science questions that can be addressed with the telescope, together with a complete description of its major subsystems. © C. Q. Noda et al. 2022., C.Q.N. was supported by the EST Project Office, funded by the Canary Islands Government (file SD 17/01) under a direct grant awarded to the IAC on ground of public interest. This project has received funding from the European Union’s Horizon 2020 Research and Innovation programme under Grant Agreements No 739500 (PRE-EST) and 653982 (GREST). This project was supported by the European Commission’s FP7 Capacities Programme under Grant Agreements No 212482 (EST Design Study) and No. 312495 (SOLARNET). It was also supported by the European Union’s Horizon 2020 Research and Innovation programme under Grant Agreement No. 824135 (SOLARNET). This work has been partially funded by the Spanish Ministry of Science and Innovation through project RTI2018-096886-B-C51, including a percentage from FEDER funds, and through the Centro de Excelencia Severo Ochoa grant SEV-2017-0709 awarded to the Instituto de Astrofísica de Andalucía in the period 2018-2022. The EST preparatory phase was supported by a grant for research infrastructures of national importance from the Swedish Research Council (registration number 2017-00625). J.J. was supported by the Ministry of Education, Youth and Sports of the Czech Republic through the EST-CZ project (LM2018095). C.K. acknowledges funding received from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 895955. Queen’s University Belfast acknowledges support from the Science and Technology Facilities Council (STFC) under grant No. ST/V003739/1. This work was supported by Fundação para a Ciência e a Tecnologia (FCT) through the research grants [UID/FIS/04434/2019], UIDB/04434/2020, UIDP/04434/2020, UIDB/00611/2020 and UIDP/00611/2020. This work was partly funded by a grant of the Austrian Science Fund (FWF): P 32958-N. J.C.R., C.J.D.B. and A.P.Y. gratefully acknowledge financial support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (SUNMAG, grant agreement 759548). J.A. was supported by Centre National d’Etudes Spatiales (CNES). G.A., M.C., L.F., V.H., A.O. and L.R.V.V acknowledge support by the Research Council of Norway through its Centres of Excellence scheme, project number 262622. L.B., M.B., R.R. acknowledge State Secretariat for Education, Research, and Innovation (SERI), Canton Ticino and Swiss National Science Foundation (grants 200020_184952, 200021_175997, CRSII5_180238) for the financial support. R. Brajša and D. Sudar acknowledge the support by the Croatian Science Foundation under project 7549 ‘Millimeter and submillimeter observations of the solar chromosphere with ALMA’. The NSO is operated by the Association of Universities for Research in Astronomy, Inc., under cooperative agreement with the National Science Foundation. The work of A.B. was partially supported by the programme ‘Excellence Initiative – Research University’ for years 2020–2026 for University of Wrocław, project no. BPIDUB.4610.15.2021.KP.B. E.S.C. acknowledges financial support from the Spanish Ministry of Science and Innovation (MICINN) through the Spanish State Research Agency, under Severo Ochoa Centres of Excellence Programme 2020-2023 (CEX2019-000920-S). L.F. and N.L. would like to acknowledge support from UK Research and Innovation Science and Technology Facilities Council grants ST/L006200/1 and ST/T000422/1. J.F. acknowledges visiting facilities at Rosseland Centre for Solar Physics (University of Oslo), in 2019. P. Gömöry, A.K. and J.R. were supported by the Science Grant Agency project VEGA 2/0048/20. I. Kontogiannis is supported by KO 6283/2-1 of the Deutsche Forschungsgemeinschaft (DFG). C.J.N. is thankful to the Science and Technology Facilities Council (STFC), for support received through grant ST/T00021X/1, and ESA, for support as an ESA Research Fellow. K.P. was supported by the Hungarian National Research, Development and Innovation Fund (grants no. NKFI K-128384 and TKP2021-NKTA-64). P.J.A. Simões acknowledges support from CNPq (contract 307612/2019-8). J.T.B. acknowledges the funding received from the European Research Council (ERC) under de European Union’s Horizon 2020 research and innovation programme (ERC Advanced Grant Agreement No. 742265). M.V. is supported by VE 1112/1-1 of the Deutsche Forschungsgemeinschaft (DFG). L.Q.Z. acknowledges that this work was supported by the National Natural Science Foundation of China (Grant No. 11727805, No. 1210030348). F.Z. acknowledges that this work was supported by the Italian MIUR-PRIN grant 2017APKP7T and by the Università degli Studi di Catania (Piano per la Ricerca Università di Catania 2020-2022, Linea di intervento 2).
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16. Cognitive profile of male mice exposed to a Ketogenic Diet; 35716801
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Ródenas-González, F., Blanco-Gandía, M.C., Miñarro, J., and Rodríguez-Arias, M.
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In recent years, nutritional interventions for different psychiatric diseases have gained increasing attention, such as the ketogenic diet (KD). This has led to positive effects in neurological disorders such as Parkinson''s disease, addiction, autism or epilepsy. The neurobiological mechanisms through which these effects are induced and the effects in cognition still warrant investigation, and considering that other high-fat diets (HFD) can lead to cognitive disturbances that may affect the results achieved, the main aim of the present work was to evaluate the effects of a KD to determine whether it can induce such cognitive effects. A total of 30 OF1 male mice were employed to establish the behavioral profile of mice fed a KD by testing anxiety behavior (Elevated Plus Maze), locomotor activity (Open Field), learning (Hebb Williams Maze), and memory (Passive Avoidance Test). The results revealed that the KD did not affect locomotor activity, memory or hippocampal-dependent learning, as similar results were obtained with mice on a standard diet, albeit with increased anxiety behavior. We conclude that a KD is a promising nutritional approach to apply in research studies, given that it does not cause cognitive alterations.
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17. Additional file 1 of Economic evaluations of radioembolization with Itrium-90 microspheres in hepatocellular carcinoma: a systematic review
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Alonso, J. C., Casans, I., González, F. M., Fuster, D., Rodríguez, A., Sánchez, N., Oyagüez, I., Burgos, R., Williams, A. O., and Espinoza, N.
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ComputingMethodologies_PATTERNRECOGNITION ,Data_FILES ,GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries) - Abstract
Additional file 1. Terminology of searching strategy in PubMed.
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18. Prevalence of symptomatic axial osteoarthritis phenotypes in Spain and associated socio-demographic, anthropometric, and lifestyle variables
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Silva-Díaz M, Blanco FJ, Quevedo Vila V, Seoane-Mato D, Pérez-Ruiz F, Juan-Mas A, Pego-Reigosa JM, Narváez J, Quilis N, Cortés R, Romero Pérez A, Fábregas Canales D, Font Gayá T, Bordoy Ferrer C, Prado-Galbarro FJ, Sánchez-Piedra C, Díaz-González F, and Bustabad-Reyes S
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Phenotypes ,Osteoarthritis ,Prevalence ,Spine - Abstract
OBJECTIVE: Axial osteoarthritis (OA) is a common cause of back and neck pain, however, few studies have examined its prevalence. The aim was to estimate the prevalence and the characteristics of symptomatic axial OA in Spain. METHODS: EPISER2016 is a cross-sectional multicenter population-based study of people aged 40 years or older. Subjects were randomly selected using multistage stratified cluster sampling. Participants were contacted by telephone to complete rheumatic disease screening questionnaires. Two phenotypes were analyzed, patients with Non-exclusive axial OA (NEA-OA) and Exclusive axial OA (EA-OA). To calculate the prevalence and its 95% confidence interval (CI), the sample design was considered and weighting was calculated according to age, sex and geographic origin. RESULTS: Prevalence of NEA-OA by clinical or clinical-radiographic criteria was 19.17% (95% CI: 17.82-20.59). The frequency of NEA-OA increased with age (being 3.6 times more likely in patients aged 80 s or more than in those between 40 and 49 years) and body mass index. It was significantly more frequent in women, as well as in the center of Spain. It was less frequent in those with a higher level of education. Lumbar OA was more frequent than cervical OA. This difference grew with increasing age and was not associated with gender. It was also greater in overweight and obese subjects. CONCLUSIONS: This is the first study on the prevalence of axial OA phenotypes in Europe describing the associated socio-demographic, anthropometric, and lifestyle variables.
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19. Personas adultas mayores y salud bio-psico-social: análisis de las experiencias profesionales, de formación, e investigación en el contexto de la pandemia de COVID-19
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Leticia Fócil-González, José R. González F., and Roberto Carlos Gonzalez-Focil
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General Medicine - Abstract
A través de una revisión de la literatura académica/científica, se analizan los principales fenómenos documentados sobre la salud bio-psico-social de las personas adultas mayores durante la pandemia de COVID-19. Se hace énfasis en los principales retos, intervenciones y propuestas, en particular las que provienen del ejercicio profesional y de la formación de profesionales de la salud.
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- 2021
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20. Prevalence of gout in the adult general population in Spain: Estimating the proportion of undiagnosed cases
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Quilis N, Sivera F, Seoane-Mato D, Pérez-Ruiz F, Sánchez-Piedra C, Díaz-González F, and Bustabad-Reyes S
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musculoskeletal diseases ,Gout ,Epidemiology ,Prevalence ,Urate crystals - Abstract
OBJECTIVE: To estimate the prevalence of gout in Spain. METHODS: Cross-sectional, population-based study of people aged 20 years or older. First, randomly selected individuals were contacted by telephone and rheumatic disease screening questionnaires were conducted. If the first screening was positive, medical records were then reviewed and/or a phone questionnaire was conducted by a rheumatologist, followed by an appointment if necessary. Newly diagnosed cases had to fulfil the ACR/EULAR 2015 criteria. To calculate the prevalence and its 95% CI, the sample design was taken into account and weighing was calculated according to age, sex and geographic origin. RESULTS: In all, 4916 individuals were included, 1361 had a positive screening result for gout (59 of them reported a prior diagnosis). Of these, 51 were classified as missing and 95 were classified as gout cases. An additional case was detected through a positive screening for fibromyalgia and Sjögren's syndrome, although a previous gout diagnosis was confirmed by a review of the medical records. Of the 96 gout cases, 31 (32%) were de novo diagnoses. The estimated weighted prevalence of gout was 2.4% (95% CI 1.95-2.95), with a higher prevalence in men (4.55% [95%CI 3.65-5.65]) than women (0.38% [95%CI 0.19-0.76]). CONCLUSION: EPISER2016 is the first population-based study to estimate the prevalence of gout in Spain. Undiagnosed patients accounted for a substantial proportion of cases, highlighting the need for population-approaches when estimating the prevalence of infra-diagnosed diseases. Reliable national approaches are key to obtaining accurate estimates of diseases to better aid healthcare and workforce planning.
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21. Experimental characterization and test-beam results of MACACO III Compton camera
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Barrientos, L., Borja-LLoret, P., Casaña, J. V., García-López, J., Hueso-González, F., Jiménez-Ramos, M. C., Muñoz, Enrique, Ros, Abel, Roser, J., Senra, C., Viegas, R., and Llosá, Gabriela
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Physics::Instrumentation and Detectors ,Proton beams ,Silicon photomultipliers ,Lanthanum (III) bromide ,Hadron therapy treatment monitoring ,Compton camera - Abstract
The IRIS group at IFIC-Valencia is developing a Compton camera prototype with the aim of applying it in hadron therapy treatment monitoring. Recently, a third version of the prototype MACACO (Medical Applications CompAct COmpton camera) has been built. The system is composed of three Lanthanum (III) bromide scintillator crystals coupled to silicon photomultipliers. To improve its performance for the final application, several detectors are tested, two different silicon photomultipliers (25 and 50 um) have been chosen as possible candidates. The 25 up photodetector provided better performance in therms of dynamic range, energy resolution (5.2/ FWHM at 511 keV) and stability with temperature variations. MACACO III has also been tested in the CNA cyclotron (Seville) with 18 MeV proton beam to produce 4.439 MeV gamma rays. Data have been acquired with a graphite target in five different positions at 2.5 nA nominal beam intensity. Images with 4.439 MeV photons have been reconstructed, demonstrating the system capability to reconstruct images at energies relevant for hadron therapy. Moreover, the system has been able to distinguish 1mm displacements in the target position.
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22. A real-life study of the medium to long-term effectiveness of a hypercaloric, hyperproteic enteral nutrition formula specifically for patients with diabetes on biochemical parameters of metabolic control and nutritional status
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Ballesteros Pomar MD, Lardiés Sánchez B, Argente Pla M, Ramos Carrasco A, Suárez Gutiérrez L, Yoldi Arrieta A, Sorribes Carreras P, Gutiérrez Medina S, Molina Soria JB, Berrio Miranda M, Leyva Martínez MS, Torregrosa Suau O, Oliván Usieto MT, Villazón González F, Abilés Osinaga J, Martín Echevarría E, and García-Malpartida K
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HbA1c ,Specific enteral formula for diabetes ,Malnutrition ,Diabetes ,Enteral nutrition ,Desnutrición, Diabetes, Enteral nutrition, Fórmula enteral específica para diabetes, HbA1c, Malnutrition, Nutrición enteral, Specific enteral formula for diabetes - Abstract
Introduction: Although current recommendations suggest the use of specific formulas in enteral nutrition in people with diabetes, there is little evidence of their long-term effectiveness in glycemic control. The main objective of this study is to evaluate the long-term efficacy (24 weeks) of a specific high-protein hypercaloric enteral nutrition formula for people with diabetes in glycemic control and in their improvement in nutritional status. Methodology: This was a multicenter, prospective, observational, real-life study of patients with long-term enteral nutrition prescription through gastrostomy or nasogastric tube who received a high protein hypercaloric formula specific for diabetes. Once the participant's informed consent was obtained and the inclusion and exclusion criteria were verified, data relating to glycemic control, inflammation parameters, biochemical data, nutritional status and gastrointestinal tolerance at 0, 12 and 24 weeks were collected. Results: 112 patients were recruited, 44.6% women, age 75.0 (12.0) years and a mean time of evolution of diabetes of 18.1 (9.5) years. The percentage of patients with malnutrition according to VGS decreased throughout the treatment from 78.6% to 29.9% (P
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- 2021
23. Serological humoral immunity following natural infection of children with high burden gastrointestinal viruses
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Baric, R.S., González, F., Becker-Dreps, S., Lindesmith, L.C., Zweigart, M.R., and Bucardo, F.
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Acute gastroenteritis (AGE) is a major cause of morbidity and mortality worldwide, resulting in an estimated 440,571 deaths of children under age 5 annually. Rotavirus, norovirus, and sapovirus are leading causes of childhood AGE. A successful rotavirus vaccine has reduced rotavirus hospitalizations by more than 50%. Using rotavirus as a guide, elucidating the determinants, breath, and duration of serological antibody immunity to AGE viruses, as well as host genetic factors that define susceptibility is essential for informing development of future vaccines and improving current vaccine candidates. Here, we summarize the current knowledge of disease burden and serological antibody immunity following natural infection to inform further vaccine development for these three high-burden viruses.
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- 2021
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24. Factors associated with long-term retention of treatment with golimumab in rheumatoid arthritis, axial spondyloarthritis, and psoriatic arthritis: an analysis of the Spanish BIOBADASER registry
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Pombo-Suarez M, Sanchez-Piedra C, Garcia-Magallón B, Pérez-Gómez A, Manrique-Arija S, Martín-Doménech R, Colazo M, Campos C, Campos J, Del Pino-Montes J, Arteaga MJ, Cea-Calvo L, Díaz-González F, and Gómez-Reino JJ
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Psoriatic arthritis ,Axial spondyloarthritis ,Medication retention rate ,Rheumatoid arthritis ,Golimumab - Abstract
Background Retention of biological treatment provides a marker of drug effectiveness and patient satisfaction. Retention of golimumab was high in clinical trial extensions and real-world studies up to 5 years in patients with immune-mediated rheumatic diseases. Objective To assess the probability of real-world long-term retention of treatment with golimumab up to 7 years after treatment initiation. Methods This retrospective noninterventional study involved analysis of the Spanish biological drugs registry, BIOBADASER. Adults who had ever received golimumab for rheumatoid arthritis (RA), axial spondyloarthritis (SpA), or psoriatic arthritis (PsA), and had initiated it > 6 months before the analysis date, were included. Results Among 685 patients (28.5% RA, 42.9% SpA, 28.6% PsA), the overall probability of retention of golimumab treatment since initiation was 71.7% (95% confidence interval 68.1-74.9) at year 1, 60.5% (56.5-64.2%) at year 2, 55.6% (51.5-59.5%) at year 3, 50.6% (46.2-54.8%) at year 4, 45.1% (40.1-50.0%) at year 5, 44.2% (39.0-49.3) at year 6, and 39.5% (32.8-46.2) at year 7. Retention was greater in patients with axial SpA or PsA versus RA (p < 0.001) and when golimumab was used as first-line treatment versus third or later lines (p < 0.001). Factors associated with greater golimumab retention in Cox regression included use as first-line biological therapy, having axial SpA or PsA rather than RA, and concomitant methotrexate therapy. Steroids were associated with lower retention. Conclusion In this real-world study of RA, axial SpA, and PsA patients, the retention rate of golimumab was 39.5% at year 7.
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- 2021
25. Alzemon: a prospective follow-up study of eslicarbazepine acetate monotherapy in patients with newly diagnosed epilepsy
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Hernández-Rubio L, Asensio-Asensio M, Tortosa-Conesa D, Alfaro-Sáez A, García-Escrivá A, Díaz-Román M, Montoya J, Méndez-Miralles MA, Bertol-Alegre V, Castro-Vilanova MD, Galiano ML, Blanco-Cantó ME, and López-González F
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Adult ,Male ,Epilepsy ,Antiepileptic drugs ,Middle Aged ,Eslicarbazepine acetate ,Monotherapy ,Dibenzazepines ,Humans ,Adults ,Anticonvulsants ,Female ,Partial epilepsy ,Prospective Studies ,Prospective study ,Aged ,Follow-Up Studies - Abstract
Eslicarbazepine acetate is a novel sodium channel blocker for use in the treatment of focal onset seizures. Prospective studies on its effectiveness in monotherapy in patients with newly diagnosed partial epilepsy in routine clinical practice are scarce.To evaluate the effectiveness of eslicarbazepine as initial monotherapy in patients with newly diagnosed partial epilepsy in routine clinical practice.A prospective, multicentre, post-authorisation study. Patients with newly diagnosed partial epilepsy aged 18 years or older without previous treatment were included. The efficacy variables were: percentage of seizure-free patients, responders and reduction in monthly frequency of seizures. The safety variables analyse the 12-month retention rate and the occurrence of adverse effects.Fifty-three patients were included. The retention rate was 77.4%. At the end of the observation period, 83% of patients were seizure-free and 92.5% had reduced their baseline frequency by 50% or more. In addition, 68% of the patients reported some adverse effect and 7.5% of them dropped out of the study for this reason. The effectiveness analysis of the subgroup of patients aged 65 years or more showed no differences with respect to the overall population.Eslicarbazepine monotherapy in patients with newly diagnosed partial epilepsy, both in the general population and in the population over 65 years old, is effective and safe in routine clinical practice.Alzemon: estudio de seguimiento prospectivo del acetato de eslicarbacepina en monoterapia en pacientes con epilepsia de diagnóstico reciente.Introducción. El acetato de eslicarbacepina es un nuevo bloqueante de los canales de sodio en el tratamiento de las crisis de inicio focal. Los estudios prospectivos sobre su efectividad en monoterapia en pacientes con epilepsia parcial de reciente diagnóstico en la práctica clínica habitual son escasos. Objetivo. Evaluar la efectividad de la eslicarbacepina en monoterapia de inicio en pacientes con epilepsia parcial de reciente diagnóstico en la práctica clínica habitual. Pacientes y métodos. Estudio postautorización prospectivo y multicéntrico. Se incluyó a pacientes con epilepsia parcial de reciente diagnóstico de 18 años o más sin tratamiento previo. Las variables de eficacia fueron: porcentaje de pacientes libres de crisis, respondedores y reducción en la frecuencia mensual de crisis. Las variables de seguridad analizan la tasa de retención a los 12 meses y la aparición de efectos adversos. Resultados. Se incluyó a 53 pacientes. La tasa de retención fue del 77,4%. Al final del período de observación, el 83% de los pacientes se encontraba libre de crisis y el 92,5% había reducido en un 50% o más su frecuencia basal. El 68% de los pacientes notificó algún efecto adverso y el 7,5% de ellos abandonó el estudio por este motivo. El análisis de efectividad del subgrupo de 65 años o más no mostró diferencias respecto a la población global. Conclusión. La eslicarbacepina en monoterapia en pacientes con epilepsia parcial de reciente diagnóstico, tanto en la población general como en la población de más de 65 años, es eficaz y segura en la práctica clínica habitual.
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- 2021
26. South American Coccinellidae (Coleoptera), part XX: systematic revision of South American Calloeneis Grote (Cryptognathini)
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Gordon, Robert D., González F., Guillermo, and Hanley, Guy A.
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Coleoptera ,Insecta ,ddc:590 ,Arthropoda ,Coccinellidae ,Animalia ,Biodiversity ,Taxonomy - Abstract
Gordon, Robert D., F, Guillermo González, Hanley, Guy A. (2020): South American Coccinellidae (Coleoptera), part XX: systematic revision of South American Calloeneis Grote (Cryptognathini). Insecta Mundi 2020 (766): 1-25, DOI: http://doi.org/10.5281/zenodo.5353544, {"references":["Belicek, J. 1976. Coccinellidae of western Canada and Alaska with analysis of the transmontane zoogeographic relationships between the fauna of British Columbia and Alberta (Insecta: Coleoptera: Coccinellidae). Quaestiones Entomologicae 12: 283-409.","Blackwelder, E. 1945. Checklist of the coleopterous insects of Mexico, Central America, the West Indies and South America. Part 3, Bulletin of the United States National Museum 185: 343-550.","Casey, T. L. 1924. Additions to the known Coleoptera of North America. Memoirs on the Coleoptera, Vol 11. New Era Printing Co.; Lancaster, PA. 1-347.","Chapin, E. A. 1955. Name changes in Coccinellidae. Psyche 62: 87-88.","Crotch, G. R. 1874. A revision of the coleopterous family Coccinellidae. E.W.Janson; London. 311 p.","Gonzalez, G. 2010. Actualizacion de la bibliografia y nuevos registros en Coccinellidae de America del Sur (Insecta: Coleoptera). Boletin de la Sociedad Entomologica Aragonesa 47: 245-256.","Gonzalez, G., G. A. Hanley, and R. D. Gordon. 2019. South American Coccinellidae (Coleoptera), Part XIX: Overview of Cryptognathini and systematic revision of South American Cryptognatha Mulsant. Insecta Mundi 0714: 1-32.","Gordon, R. D. 1971. A generic review of the Cryptognathini, new tribe, with a description of a new genus (Coleoptera: Coccinellidae). Acta Zoologica Lilloana 26: 179-196.","Gordon, R. D. 1978. West Indian Coccinellidae II (Coleoptera): Some scale predators with keys to genera and species. The Coleopterists Bulletin 32: 205-218.","Gordon, R. D. 1985. The Coccinellidae (Coleoptera) of America north of Mexico. Journal of the New York Entomological Society 93: 1-912.","Gordon, R. D. 1987. A catalogue of the Crotch collection of Coccinellidae (Coleoptera). Occasional Papers on Systematic Entomology 3: 1-46.","Gordon, R. D., C. Canepari, and G. A. Hanley. 2013. South American Coccinellidae (Coleoptera). Part XII: New name for Cyra Mulsant, review of Brachiacantha genera, and systematic revision of Cleothera Mulsant, Hinda Mulsant and Serratitibia Gordon and Canepari, new genus. Insecta Mundi 0278: 1-150.","Grote, A. R. 1873. On Mr. Scudder's systematic revision of some New England butterflies (3rd Paper). The Canadian Entomologist 5: 143-145.","Hubner, J. 1816-1826. Verzeichnis bekannter Schmettlinge (sic). Bey dem Verfasser zu finden; Augs- burg, Germany. 431 p.","Korschefsky, R. 1931. Coccinellidae I. Coleopterorum Catalogus. Part 118. W. Junk; Berlin. 224 p.","Korschefsky, R. 1936. Eine neue Cryptognatha-Art aus Sud-Amerika. Arbeiten uber morphologische und taxonomische Entomologie aus Berlin-Dahlem 3: 298-300.","Mulsant, M. E. 1850. Species de coleopteres trimeres securipalpes. Annales des Sciences Physiques et Naturelles, Lyon 2: 1-1104.","Seago, A. E., J. A. Giorgi, L. Jiahui, and A. Slipinski. 2011. Phylogeny, classification and evolution of ladybird beetles (Coleoptera: Coccinellidae) based on simultaneous analysis of molecular and morphological data. Molecular Phylogenetics and Evolution 60: 137-151.","Slipinski, A. 2007. Australian ladybird beetles (Coleoptera: Coccinellidae). Their biology and classifi- cation. Australian Biological Resources Study; Canberra. v-xvii + 286 p."]}
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- 2020
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27. [Refractory severe hypertriglyceridemia treated with apheresis. Report of one case]
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Camila, Jure B, Lucy, Sapiain P, and Susana, González F
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Adult ,Hypertriglyceridemia ,Male ,Pancreatitis ,Acute Disease ,Blood Component Removal ,Humans ,Hyperlipidemias ,Triglycerides - Abstract
Severe Hypertriglyceridemia (HTG) is associated with complications such as acute pancreatitis (AP) with high morbidity and mortality rates. We report a 42 years-old man with refractory HTG diagnosed at 19 years of age, and multiple episodes of AP, admitted with the suspicion of a new AP episode. Serum triglycerides were over 2000 mg/dl. His body mass index was 18 kg/m2, there was no evidence of xanthomas or xanthelasmas, but lipemia retinalis was found. Management included heparin and insulin, added to his usual treatment with fibrates, statins, omega-3 fatty acids, and orlistat. Due to lack of response, apheresis was started. After five sessions, triglycerides decreased to 588 mg/dl (82% reduction) and levels remained below 1000 mg/dl with daily apheresis. The patient continued with weekly sessions as outpatient with a sustained good response.
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- 2020
28. Stress-related coping styles in myalgic university students: A case control study
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Ardizone-García I, Jiménez-Ortega L, Domínguez-Gordillo A, Sánchez-Sánchez T, Pérez-González F, Soto-Goñi X, Sánchez-Labrador L, and Viñals Ac
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stomatognathic diseases ,Stress (linguistics) ,Psychology ,Clinical psychology - Abstract
Background: Patients suffering pain-related temporomandibular disorders (TMD) exhibit greater levels of psychological distress, environmental stress, somatic symptoms, anxiety, depression, somatic awareness, pain catastrophizing, and impaired pain coping strategies compared to pain-free controls. However, little is known about psychological factors involved in the different TMD types fulfilling DC/TMD criteria. Furthermore, regardless of severity, the role of general coping strategies and styles in TMD is not yet well understood. The main goal of this study was to investigate stress-related coping styles, anxiety and personality traits in a group of dentistry students suffering from temporomandibular disorder with myalgia. Methods: A cohort of 102 university students was initially recruited for this study. Following clinical evaluation, a myalgia group (24 participants) and a control group (25 participants) were formed. Participants were later assessed in anxiety, stress coping strategies, and personality measures by using the State-trait anxiety inventory (STAI), coping response inventory (CRI), and Neo Five-Factor Inventory (NEO-FFI) questionnaires respectively.Results: The myalgia group presented greater levels of trait anxiety and neuroticism in comparison to the control group. Participants with myalgia also showed higher levels of avoidance coping which was the only reliable predictor of TMD. Conclusions: Avoidance coping strategies are generally considered maladaptive, as they seem to increase perceived stress, a robust predictor of TMD. Interventions aimed at reducing stress and anxiety levels, increase emotional stability, and preventing maladaptive coping styles, might improve temporomandibular health and prevent the myalgia and its chronification.
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- 2020
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29. Prevalence of fibromyalgia and associated factors in Spain
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Font Gayà T, Bordoy Ferrer C, Juan Mas A, Seoane-Mato D, Álvarez Reyes F, Delgado Sánchez M, Martínez Dubois C, Sánchez-Fernández SA, Marena Rojas Vargas L, García Morales PV, Olivé A, Rubio Muñoz P, Larrosa M, Navarro Ricós N, Sánchez-Piedra C, Díaz-González F, and Bustabad-Reyes S
- Abstract
OBJECTIVES: The prevalence of fibromyalgia (FM) differs depending on the population studied. The main objective of the EPISER2016 study was to estimate the prevalence of FM in adults in Spain. The secondary objective was to evaluate the association with sociodemographic and anthropometric characteristics and smoking. METHODS: This is a population-based cross-sectional multicentre study. The random selection was based on multistage stratified cluster sampling. The final sample comprised 4916 persons aged =20 years. Participants were contacted by telephone for completion of a screening survey. Investigating rheumatologists evaluated positive results (review of medical records and/or telephone interview, with medical visit if needed) to confirm the diagnosis. Prevalence and 95% confidence interval were calculated, taking into account the sample design. Weighing was applied based on age, sex, and geographic origin. Predictive models were constructed to analyse which sociodemographic, anthropometric and lifestyle variables in the call centre questionnaire were associated with the presence of FM. RESULTS: 602 subjects (12.25%) had a positive screening result for FM, of which 24 were missing (3.99%). A total of 141 cases of FM were recorded. The estimated prevalence was 2.45% (95% CI, 2.06-2.90). Female sex was the variable most associated with FM, with an odds ratio (OR) of 10.156 (95% CI, 5.068-20.352). Peak prevalence was at 60-69 years (p=0.009, OR=6.962). FM was 68% more frequent in obese individuals (OR, 1.689; 95% CI, 1.036-2.755). CONCLUSIONS: The prevalence of FM in adults in Spain barely changed between 2000 and 2016 and it is similar to that observed in Europe as a whole.
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- 2020
30. Prevalence of systemic lupus erythematosus in Spain: higher than previously reported in other countries?
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Cortés Verdú R, Pego-Reigosa JM, Seoane-Mato D, Morcillo Valle M, Palma Sánchez D, Moreno Martínez MJ, Mayor González M, Atxotegi Sáenz de Buruaga J, Urionagüena Onaindia I, Blanco Cáceres BA, Silva-Fernández L, Sivera F, Blanco FJ, Sánchez-Piedra C, Díaz-González F, Bustabad S, and Working Group Proyecto EPISER2016
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systemic lupus erythematosus ,prevalence ,epidemiology ,skin and connective tissue diseases - Abstract
Objectives. Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by the Spanish Society of Rheumatology, the prevalence estimate of SLE in the general adult population in Spain has been updated and its association with sociodemographic, anthropometric and lifestyle variables has been explored. Methods. Population-based multicentre cross-sectional study, with multistage stratified and cluster random sampling. Participants were contacted by telephone to carry out a questionnaire for the screening of SLE. Investigating rheumatologists evaluated positive results (review of medical records and/or telephone interview, with medical visit if needed) to confirm the diagnosis. To calculate the prevalence and its 95% CI, the sample design was taken into account and weighing was calculated considering age, sex and geographic origin. Multivariate logistic regression models were defined to analyse which sociodemographic, anthropometric and lifestyle variables included in the telephone questionnaire were associated with the presence of SLE. Results. 4916 subjects aged 20 years or over were included. 16.52% (812/4916) had a positive screening result for SLE. 12 cases of SLE were detected. The estimated prevalence was 0.21% (95% CI: 0.11, 0.40). SLE was more prevalent in the rural municipalities, with an odds ratio (OR) = 4.041 (95% CI: 1.216, 13.424). Conclusion. The estimated prevalence of SLE in Spain is higher than that described in most international epidemiological studies, but lower than that observed in ethnic minorities in the United States or the United Kingdom.
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- 2020
31. A cross-disease meta-GWAS identifies four new susceptibility loci shared between systemic sclerosis and Crohn’s disease
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González-Serna, D., Ochoa, E., López-Isac, E., Julià, A., Degenhardt, F., Ortego-Centeno, N., Radstake, T.R.D.J., Franke, A., Marsal, S., Mayes, M.D., Martín, J., Márquez, A., Assassi, S., Zhou, X., Tan, F.K., Arnett, F.C., Reveille, J.D., Gorlova, O., Chen, W.V., Ying, J., Gregersen, P.K., Lee, A.T., Voskuyl, A.E., de Vries-Bouwstra, J., Magro-Checa, C., Broen, J., Koeleman, B.P.C., Simeón, C.P., Fonollosa, V., Guillén, A., Carreira, P., Castellví, I., González-Gay, M.A., Ríos, R., Callejas-Rubio, J.L., Vargas-Hitos, J.A., García-Portales, R., Camps, M.T., Fernández-Nebro, A., González-Escribano, M.F., García-Hernández, F.J., Castillo, M.J., Aguirre, M.Á., Gómez-Gracia, I., Rodríguez-Rodríguez, L., Fernández-Gutiérrez, B., de la Peña, P.G., Vicente, E., Andreu, J.L., Fernández de Castro, M., López-Longo, F.J., Martínez, L., Espinosa, G., Tolosa, C., Pros, A., Rodríguez-Carballeira, M., Narváez, F.J., Rubio-Rivas, M., Ortiz-Santamaría, V., Madroñero, A.B., Díaz, B., Trapiella, L., Sousa, A., Egurbide, M.V., Fanlo-Mateo, P., Sáez-Comet, L., Díaz-González, F., Hernández, V., Beltrán, E., Román-Ivorra, J.A., Grau, E., Alegre-Sancho, J.J., Blanco-García, F.J., Oreiro, N., Freire, M., Balsa, A., Ortiz, A.M., Hunzelmann, N., Riemekasten, G., Distler, J.H.W., Witte, T., Airó, P., Beretta, L., Santaniello, A., Bellocchi, C., Lunardi, C., Moroncini, G., Gabrielli, A., and Scleroderma, Genetic, Consortium
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Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn’s disease (CD), some of which confer susceptibility to both diseases. In order to identify new risk loci shared between these two immune-mediated disorders, we performed a cross-disease meta-analysis including GWAS data from 5, 734 SSc patients, 4, 588 CD patients and 14, 568 controls of European origin. We identified 4 new loci shared between SSc and CD, IL12RB2, IRF1/SLC22A5, STAT3 and an intergenic locus at 6p21.31. Pleiotropic variants within these loci showed opposite allelic effects in the two analysed diseases and all of them showed a significant effect on gene expression. In addition, an enrichment in the IL-12 family and type I interferon signaling pathways was observed among the set of SSc-CD common genetic risk loci. In conclusion, through the first cross-disease meta-analysis of SSc and CD, we identified genetic variants with pleiotropic effects on two clinically distinct immune-mediated disorders. The fact that all these pleiotropic SNPs have opposite allelic effects in SSc and CD reveals the complexity of the molecular mechanisms by which polymorphisms affect diseases.
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- 2020
32. Mycophenolate Mofetil in C3 Glomerulopathy and Pathogenic Drivers of the Disease
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Caravaca-Fontán F, Díaz-Encarnación MM, Lucientes L, Cavero T, Cabello V, Ariceta G, Quintana LF, Marco H, Barros X, Ramos N, Rodríguez-Mendiola N, Cruz S, Fernández-Juárez G, Rodríguez A, Pérez de José A, Rabasco C, Rodado R, Fernández L, Pérez Gómez V, Ávila AI, Bravo L, Lumbreras J, Allende N, Sanchez de la Nieta MD, Rodríguez E, Olea T, Melgosa M, Huerta A, Miquel R, Mon C, Fraga G, de Lorenzo A, Draibe J, Cano-Megías M, González F, Shabaka A, López-Rubio ME, Fenollosa MÁ, Martín-Penagos L, Da Silva I, Alonso Titos J, Rodríguez de Córdoba S, Goicoechea de Jorge E, Praga M, Spanish Group for the Study of Glomerular Diseases GLOSEN, Instituto de Salud Carlos III, Red Española de Investigación Renal, Comunidad de Madrid, Ministerio de Ciencia, Innovación y Universidades (España), Ministerio de Economía y Competitividad (España), Caravaca-Fontán, Fernando [0000-0002-5830-9663], Díaz-Encarnación, Montserrat M. [0000-0001-5172-3370], Lucientes, Laura [0000-0001-5596-370X], Cavero, Teresa [0000-0001-5187-9906], Ariceta, Gema [0000-0003-1763-1098], Quintana, Luis F. [0000-0001-7582-8476], Barros, Xoana [0000-0001-9690-9769], Ramos, Natalia [0000-0001-9832-326X], Rodríguez-Mendiola, Nuria [0000-0001-6994-7161], Fernández-Juárez, Gema [0000-0001-6641-7763], Pérez de José, Ana [0000-0002-6952-1459], Pérez Gómez, Vanessa [0000-0003-4558-5236], Lumbreras, Javier [0000-0003-1855-0724], Sánchez de la Nieta, María Dolores [0000-0001-8574-0013], Olea, Teresa [0000-0003-2370-1048], Melgosa, Marta [0000-0001-6236-414X], Huerta, Ana [0000-0003-3342-7628], de Lorenzo, Alberto [0000-0001-8847-083X], Draibe, Juliana [0000-0002-2819-8560], González, Fayna [0000-0002-2313-2511], Shabaka, Amir [0000-0001-7039-4701], Martín-Penagos, L. [0000-0003-0159-7358], Rodríguez de Córdoba, Santiago [0000-0001-6401-1874], Praga, Manuel [0000-0001-9270-1071], Goicoechea de Jorge, Elena [0000-0002-4978-2483], Caravaca-Fontán, Fernando, Díaz-Encarnación, Montserrat M., Lucientes, Laura, Cavero, Teresa, Ariceta, Gema, Quintana, Luis F., Barros, Xoana, Ramos, Natalia, Rodríguez-Mendiola, Nuria, Fernández-Juárez, Gema, Pérez de José, Ana, Pérez Gómez, Vanessa, Lumbreras, Javier, Sánchez de la Nieta, María Dolores, Olea, Teresa, Melgosa, Marta, Huerta, Ana, de Lorenzo, Alberto, Draibe, Juliana, González, Fayna, Shabaka, Amir, Martín-Penagos, L., Rodríguez de Córdoba, Santiago, Praga, Manuel, and Goicoechea de Jorge, Elena
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Nephrology ,Male ,Time Factors ,Epidemiology ,030232 urology & nephrology ,Disease ,Critical Care and Intensive Care Medicine ,Gastroenterology ,0302 clinical medicine ,Glomerulonephritis ,Adrenal Cortex Hormones ,Recurrence ,Risk Factors ,Medicine ,C3 glomerulopathy ,Child ,0303 health sciences ,Proteinuria ,Mycophenolate mofetil ,Remission Induction ,Complement C3 ,Middle Aged ,Treatment Outcome ,Alternative complement pathway ,Disease Progression ,Drug Therapy, Combination ,Female ,medicine.symptom ,Immunosuppressive Agents ,Cohort study ,Adult ,medicine.medical_specialty ,Adolescent ,Lower risk ,03 medical and health sciences ,Young Adult ,Glomerulopathy ,Internal medicine ,Humans ,mycophenolate mofetil ,030304 developmental biology ,Retrospective Studies ,Transplantation ,business.industry ,Mycophenolic Acid ,medicine.disease ,Discontinuation ,Spain ,Propensity score matching ,business - Abstract
12 p.-4 fig.-4 tab., BACKGROUND AND OBJECTIVES: C3 glomerulopathy is a complement-mediated disease arising from abnormalities in complement genes and/or antibodies against complement components. Previous studies showed that treatment with corticosteroids plus mycophenolate mofetil (MMF) was associated with improved outcomes, although the genetic profile of these patients was not systematically analyzed. This study aims to analyze the main determinants of disease progression and response to this therapeutic regimen., DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a retrospective, multicenter, observational cohort study in 35 nephrology departments belonging to the Spanish Group for the Study of Glomerular Diseases. Patients diagnosed with C3 glomerulopathy (n=81) or dense deposit disease (n=16) between January 1995 and March 2018 were enrolled. Multivariable and propensity score matching analyses were used to evaluate the association of clinical and genetic factors with response to treatment with corticosteroids and MMF as measured by proportion of patients with disease remission and kidney survival (status free of kidney failure)., RESULTS: The study group comprised 97 patients (84% C3 glomerulopathy, 16% dense deposit disease). Forty-two patients were treated with corticosteroids plus MMF, and this treatment was associated with a higher rate of remission and lower probability of kidney failure (79% and 14%, respectively) compared with patients treated with other immunosuppressives (24% and 59%, respectively), or ecluzimab (33% and 67%, respectively), or conservative management (18% and 65%, respectively). The therapeutic superiority of corticosteroids plus MMF was observed both in patients with complement abnormalities and with autoantibodies. However, patients with pathogenic variants in complement genes only achieved partial remission, whereas complete remissions were common among patients with autoantibody-mediated forms. The main determinant of no remission was baseline proteinuria. Relapses occurred after treatment discontinuation in 33% of the patients who had achieved remission with corticosteroids plus MMF, and a longer treatment length of MMF was associated with a lower risk of relapse., CONCLUSIONS: The beneficial response to corticosteroids plus MMF treatment in C3 glomerulopathy appears independent of the pathogenic drivers analyzed in this study., Work in this study was supported by the Instituto de Salud CarlosIII/ Fondo Europeo de Desarrollo Regional (ISCIII/FEDER) grant PI16/01685 and Red de Investigación Renal (RedInRen) (RD12/0021/0029) (to M. Praga), and the Autonomous Region of Madrid (S2017/BMD-3673) (to S. Rodríguez de Córdoba and M. Praga).E. Goicoechea de Jorge is supported by the Spanish “Ministerio de Ciencia, Innovación y Universidades” (RYC-2013-13395 and RTI2018-095955-B-100). S. Rodríguez de Córdoba is supported by Ministerio de Economía y Competitividad/FEDER grant SAF2015-66287R and Autonomous Region of Madrid grant S2017/BMD3673.
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- 2020
33. Prevalence of systemic lupus erythematosus in Spain: higher than previously reported in other countries?
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Cortés Verdú R, Pego-Reigosa JM, Seoane-Mato D, Morcillo Valle M, Palma Sánchez D, Moreno Martínez MJ, Mayor González M, Atxotegi Sáenz de Buruaga J, Urionagüena Onaindia I, Blanco Cáceres BA, Silva-Fernández L, Sivera F, Blanco FJ, Sánchez-Piedra C, Díaz-González F, and Bustabad S
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systemic lupus erythematosus ,prevalence ,epidemiology - Abstract
Objectives. Prevalence of SLE varies among studies, being influenced by study design, geographical area and ethnicity. Data about the prevalence of SLE in Spain are scarce. In the EPISER2016 study, promoted by the Spanish Society of Rheumatology, the prevalence estimate of SLE in the general adult population in Spain has been updated and its association with sociodemographic, anthropometric and lifestyle variables has been explored. Methods. Population-based multicentre cross-sectional study, with multistage stratified and cluster random sampling. Participants were contacted by telephone to carry out a questionnaire for the screening of SLE. Investigating rheumatologists evaluated positive results (review of medical records and/or telephone interview, with medical visit if needed) to confirm the diagnosis. To calculate the prevalence and its 95% CI, the sample design was taken into account and weighing was calculated considering age, sex and geographic origin. Multivariate logistic regression models were defined to analyse which sociodemographic, anthropometric and lifestyle variables included in the telephone questionnaire were associated with the presence of SLE. Results. 4916 subjects aged 20 years or over were included. 16.52% (812/4916) had a positive screening result for SLE. 12 cases of SLE were detected. The estimated prevalence was 0.21% (95% CI: 0.11, 0.40). SLE was more prevalent in the rural municipalities, with an odds ratio (OR) = 4.041 (95% CI: 1.216, 13.424). Conclusion. The estimated prevalence of SLE in Spain is higher than that described in most international epidemiological studies, but lower than that observed in ethnic minorities in the United States or the United Kingdom.
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- 2020
34. Prevalence of symptomatic osteoarthritis in Spain: EPISER2016 study
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Blanco FJ, Silva-Díaz M, Quevedo Vila V, Seoane-Mato D, Pérez Ruiz F, Juan-Mas A, Pego-Reigosa JM, Narváez J, Quilis N, Cortés R, Romero Pérez A, Fábregas Canales D, Font Gayá T, Bordoy Ferrer C, Sánchez-Piedra C, Díaz-González F, and Bustabad-Reyes S
- Abstract
INTRODUCTION: The Spanish Society of Rheumatology carried out the EPISER2000 study in 2000 to determine the prevalence of osteoarthritis and other rheumatic diseases in the Spanish population. Recent sociodemographic changes and lifestyle habits in Spain justified updating the epidemiological data on osteoarthritis and other rheumatic diseases (EPISER2016-study). OBJECTIVE: To estimate the prevalence of symptomatic osteoarthritis of the cervical spine, lumbar spine, hip, knee and hand in the adult population in Spain. MATERIAL AND METHODS: Cross-sectional population-based study. A multistage and stratified random cluster sampling was carried out. The participants were contacted by telephone to complete an osteoarthritis screening questionnaire. A rheumatologist confirmed or discarded the diagnosis. The ACR-clinical-criteria were used to diagnose hand-osteoarthritis and the ACR-clinical-radiological criteria to diagnose knee- and hip-osteoarthritis. To estimate the prevalence and its 95% confidence interval, weights were calculated according to the probability of selection in each of the sampling stages. RESULTS: The prevalence of osteoarthritis in Spain in one or more of the locations studied was 29.35%. The prevalence of cervical-osteoarthritis was 10.10% and of lumbar-osteoarthritis 15.52%. Both are more frequent in women and at older ages, as well as in people with low levels of education and obesity. The prevalence of hip-osteoarthritis was 5.13%, that of knee-osteoarthritis 13.83%, these are associated with female sex, overweight and obesity. The prevalence of hand osteoarthritis was 7.73%. It is more frequent in women, who are obese, with a low educational level and who are older. CONCLUSION: The EPISER2016 study is the first to analyse the prevalence of symptomatic osteoarthritis in 5 locations (cervical, lumbar, knee, hip and hands) in Spain. Lumbar spine osteoarthritis is the most prevalent.
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- 2020
35. The prevalence of rheumatoid arthritis in Spain
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Silva-Fernández L, Macía-Villa C, Seoane-Mato D, Cortés-Verdú R, Romero-Pérez A, Quevedo-Vila V, Fábregas-Canales D, Antón-Pagés F, Añez G, Brandy A, Martínez-Dubois C, Rubio-Muñoz P, Sánchez-Piedra C, Díaz-González F, and Bustabad-Reyes S
- Abstract
Rheumatoid arthritis (RA) prevalence is believed to be around 1% worldwide, although it varies considerably among different populations. The aim of EPISER2016 study was to estimate the prevalence of RA in the general adult population in Spain. We designed a population-based cross-sectional study. A national survey was conducted between November 2016 and October 2017 involving a probabilistic sample from the general population aged 20 years or older. Subjects were randomly selected for phone screening using a computer-assisted telephone interviewer system. Positive RA screening results were evaluated by a rheumatologist. Cases fulfilled the 1987 ACR and/or the 2010 ACR/EULAR criteria; previous diagnosis established by a rheumatologist and clearly identified in medical records were also accepted regardless of the criteria used. Prevalence estimates with 95% CI were calculated taking into account the design of the sample (weighting based on age, sex, and geographic origin using as a reference the distribution of the population in Spain). 4916 subjects participated in the study and 39 RA cases were confirmed. RA estimated prevalence was 0.82% (95% CI 0.59-1.15). Mean age of RA cases was 60.48 (14.85) years, they were more frequently women (61.5%), from urban areas (74.4%), non-smokers (43.6%), and with a high body mass index (53.8% with overweight). Extrapolating to the population in Spain (approximately 37 million are >= 20 years old), it was estimated that there were between 220,000 and 430,000 people aged 20 years or older with RA. No undiagnosed cases were detected, which could be related to the establishment of early arthritis clinics around the country, increasing the rates of diagnosis during early phases of RA.
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- 2020
36. Prevalence of symptomatic osteoarthritis in Spain: EPISER2016 study
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Blanco FJ, Silva-Díaz M, Quevedo Vila V, Seoane-Mato D, Pérez Ruiz F, Juan-Mas A, Pego-Reigosa JM, Narváez J, Quilis N, Cortés R, Romero Pérez A, Fábregas Canales D, Font Gayá T, Bordoy Ferrer C, Sánchez-Piedra C, Díaz-González F, Bustabad-Reyes S, and en representación del Grupo de Trabajo del Proyecto EPISER2016
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musculoskeletal diseases - Abstract
INTRODUCTION: The Spanish Society of Rheumatology carried out the EPISER2000 study in 2000 to determine the prevalence of osteoarthritis and other rheumatic diseases in the Spanish population. Recent sociodemographic changes and lifestyle habits in Spain justified updating the epidemiological data on osteoarthritis and other rheumatic diseases (EPISER2016-study). OBJECTIVE: To estimate the prevalence of symptomatic osteoarthritis of the cervical spine, lumbar spine, hip, knee and hand in the adult population in Spain. MATERIAL AND METHODS: Cross-sectional population-based study. A multistage and stratified random cluster sampling was carried out. The participants were contacted by telephone to complete an osteoarthritis screening questionnaire. A rheumatologist confirmed or discarded the diagnosis. The ACR-clinical-criteria were used to diagnose hand-osteoarthritis and the ACR-clinical-radiological criteria to diagnose knee- and hip-osteoarthritis. To estimate the prevalence and its 95% confidence interval, weights were calculated according to the probability of selection in each of the sampling stages. RESULTS: The prevalence of osteoarthritis in Spain in one or more of the locations studied was 29.35%. The prevalence of cervical-osteoarthritis was 10.10% and of lumbar-osteoarthritis 15.52%. Both are more frequent in women and at older ages, as well as in people with low levels of education and obesity. The prevalence of hip-osteoarthritis was 5.13%, that of knee-osteoarthritis 13.83%, these are associated with female sex, overweight and obesity. The prevalence of hand osteoarthritis was 7.73%. It is more frequent in women, who are obese, with a low educational level and who are older. CONCLUSION: The EPISER2016 study is the first to analyse the prevalence of symptomatic osteoarthritis in 5 locations (cervical, lumbar, knee, hip and hands) in Spain. Lumbar spine osteoarthritis is the most prevalent.
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- 2020
37. Experimental characterization of MACACO III Compton telescope for hadron therapy treatment monitoring
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Barrientos, L., Borja-LLoret, P., Casaña, J. V., García López, J., Hueso-González, F., Jiménez-Ramos, M. C., Lacasta Llácer, Carlos, Muñoz, Enrique, Ros García, Ana, Roser, J., Senra, C., Solaz, Carles, Viegas, R., Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Ministerio de Economía y Competitividad (España), European Commission, Consejo Superior de Investigaciones Científicas (España), and Generalitat Valenciana
- Abstract
Trabajo presentado a las Jornadas de Física Médica, organizadas por la Real Sociedad Española de Física y el IFIC a través de la instalación de Física Médica IFIMED, celebradas virtualmente del 14 al 15 de diciembre de 2020., La terapia hadrónica es una técnica de tratamiento del cáncer consistente en la irradiación de tumores con protones u otros iones ligeros. El uso de esta técnica se ha incrementado por su ventaja de maximización de la dosis depositada sobre un tumor y de reducción de toxicidad del tratamiento comparado con la radioterapia convencional. Sin embargo, una de sus desventajas es la dificultad en la monitorización del rango del haz. Las cámaras Compton han resurgido como posibles candidatas para la monitorización de la terapia hadrónica, mediante la detección de los fotones producidos en la desexcitación de núcleos de los tejidos irradiados.El grupo IRIS del IFIC en Valencia se encuentra desarrollando un prototipo de una cámara Compton con la finalidad de ser empleada en monitorización de la terapia hadrónica. El prototipo MACACO (Medical Applications CompAct COmpton camera) se compone de cristales centelleadores de LaBr3 acoplados a una matriz de fotomultiplicadores de silicio. Con la finalidad de mejorar las prestaciones del prototipo, se ha construido una tercera versión que presenta un rendimiento mejorado respecto de sus predecesores. Los nuevos detectores de MACACO III se componen de cristales continuos de LaBr3 de 25,8 x 25,8 mm2 y 5 mm. El sistema de lectura AliVATA, desarrollado por el grupo, opera el ASIC VATA64HDR16 utilizado como electrónica de lectura. La caracterización de los detectores en el laboratorio se ha realizado utilizando fuentes radiactivas de 22Na, 152Eu y 137Cs. El mejor valor de resolución energética obtenido ha sido de 4.8 % FWHM a 662 keV, resolución angular de 6.0° FWHM a 1275 keV y eficiencia de detección en coincidencias de 1 x 10−3 a 1275 keV. A partir de los datos experimentales se han reconstruido imágenes de una fuente puntual de 22Na seleccionando eventos dobles y triples. El código de reconstrucción de MACACO III produce imágenes cuatridimensionales (energía y posición) usando eventos dobles o triples. Imágenes con la combinación de estos dos tipos de eventos ha sido recientemente conseguida. La FWHM de las imágenes reconstruidas fue de 2.4 mm y 3.3 mm FWHM a 1275 keV respectivamente a una distancia de la fuente de 70 mm. Con la finalidad de reproducir los resultados experimentales, MACACO III ha sido simulado en GATE v8.2 utilizando el módulo CCMod, obteniendo una buena correlación con los datos experimentales. MACACO III también ha sido caracterizado en aceleradores, con el fin de evaluar su respuesta en escenarios más realistas. Recientemente se ha testeado en el CNA (Sevilla) en un haz de protones de 18 MeV sobre un blanco de grafito. Los datos experimentales fueron tomados con el blanco en distintas posiciones y diferentes intensidades de haz. Imágenes con dos y tres planos fueron reconstruidas exitosamente en cada caso pudiendo distinguir distancias de 1 mm de separación del blanco. Futuras mejoras y pruebas en centros clínicos están en curso para alcanzar las prestaciones requeridas para la aplicación., This work has received funding from the Spanish Ministerio de Ciencia e Innovación (PID2019-110657RB-I00, FPA2017-85611-R and SEV-2014-0398), from Generalitat Valenciana (AICO/2019/070), from CSIC PIC 2018 programme (N2018FR0032) and from European Commission H2020 ENSAR2-MediNet (project number 654002). Group members are supported by Ramón y Cajal, SEJI and GENT programmes, UVEG Atracció de Talent, Generalitat Valenciana and Spanish Ministerio de Universidades FPU predoctoral contracts
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- 2020
38. Re: Dental implant placement through impacted teeth or residual roots as an alternative to invasive extraction surgeries: a systematic literature review
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Pérez-González, F., Sánchez-Labrador, L., Molinero-Mourelle, Pedro, Sáez-Alcaide, L.M., Cortés-Bretón-Brinkmann, J., Torres García-Denche, J., López-Quiles, J., and Martinez-González, J.M.
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Dental Implants ,Dental Implants, Single-Tooth ,Otorhinolaryngology ,Dental Implantation, Endosseous ,Tooth, Impacted ,Humans ,Surgery ,Oral Surgery ,610 Medizin und Gesundheit - Published
- 2022
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39. Is Dental Implant Placement Compatible in Patients Treated with Bisphosphonates? A Literature Review
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López Quiles J, Iglesias Velázquez O, Sánchez Labrador L, Pérez González F, and Meniz García C
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business.industry ,medicine.medical_treatment ,Geography, Planning and Development ,Dentistry ,medicine.disease ,Osteopenia ,Malignant hypercalcemia ,Oral and maxillofacial surgery ,General Earth and Planetary Sciences ,Medicine ,In patient ,business ,Dental implant ,Water Science and Technology - Published
- 2019
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40. [Pediatric onychomycosis: Update and management]
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Daniela A, Alfaro S and Carmen G, González F
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Antifungal Agents ,Adolescent ,Child, Preschool ,Onychomycosis ,Humans ,Infant ,Child ,Global Health ,Pediatrics - Abstract
Onychomycosis (OM) is a fungal infection of the nails, whose main etiologic agent is Trichophytum rubrum. Although, it is an unusual pathology in children, in the last years an increase in its preva lence has been observed. To date, there are several studies and clinical guidelines for OM in adults. However, literature in children is scarce, which makes pediatric treatment difficult. The objective of this publication was to review the current literature in order to establish diagnostic methods for OM, national and international epidemiological data, and to provide treatment options taking into account their efficiency and safety profile in the pediatric population.
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- 2019
41. Losses to follow-up of HIV-infected people in the Spanish VACH cohort over the period between 2013 and 2014: The importance of sociodemographic factors
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Teira R, Espinosa N, Gutiérrez MM, Montero M, Martínez E, González F, Lozano de León F, Téllez F, Galindo MJ, Peraire J, Deig E, and Muñoz-Sánchez P
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- 2019
42. Child hospital admissions associated with influenza virus infection in 6 Spanish cities (2014-2016) Hospitalizaciones infantiles asociadas a infección por virus de la gripe en 6 ciudades de España (2014-2016)
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Arístegui Fernández, J., González Pérez-Yarza, E., Mellado Peña, M.J., Rodrigo Gonzalo de Líria, Carlos, Hernández Sampelayo, T., García García, J.J., Ruiz Contreras, J., Moreno Pérez, D., Garrote Llanos, E., Ramos Amador, J.T., Cilla Eguiluz, C.G., Méndez Hernández, M., Aristegui, J., Garrote, E., Larrauri, A., Pérez-Yarza, E.G., Cilla, G., Unsain, M., Contreras, J.R., García-Ochoa, E., Gordillo, J.C., Sampelayo, T.H., Rodríguez, R., González, F., Mellado, M.J., Calvo, C., Méndez, A., Bustamante, J., Salas, D., Lacasta, C., Ramos, J.T., Illán, M., Mendez, M., Barjuan, M., García, J.J., Urraca, S., Caballero, M., Launes, C., Fábregas Martori, Ana, Esmel Vilomara, Roger, Antón, Andrés, Moreno, D., Valdivielso, A.I., Piñero, P., and Carazo, B.
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Virus de la gripe ,Hospitalizaciones ,Influenza virus ,Children ,Niños ,Hospital admissions - Abstract
Introduction: There are only a limited number of studies on the impact of influenza in the Spanish child population. The present work intends to increase this knowledge by studying some key aspects, such as the incidence of hospital admissions, clinic variables, comorbidities, and the vaccination status in the hospitalised children. Methods: A retrospective, observational study was conducted by reviewing the medical records of children under 15 years and hospitalised due to community acquired influenza confirmed microbiologically, during 2 ́flu seasons (2014-2015 and 2015-2016). The study was carried out in 10 hospitals of 6 cities, which represent approximately 12% of the Spanish child population. Results: A total of 907 children were admitted to hospital with main diagnosis of influenza infection (447 < 2 years), estimating an average annual rate of hospitalisation incidence of 0.51 cases / 1,000 children (95% CI; 0.48-0.55). Just under half (45%) of the cases had an underlying disease considered a risk factor for severe influenza, and most (74%) had not been vaccinated. The percentage of children with underlying diseases increased with age, from 26% in children < 6 months to 74% in children >10 years. Admission to the PICU was required in 10% (92) of the cases, mainly due to acute respiratory failure. Conclusion: Influenza continues to be an important cause of hospitalisation in the Spanish child population. Children < 6 months of age and children with underlying diseases make up the majority (> 50%) of the cases. Many of the severe forms of childhood influenza that occur today could be avoided if current vaccination guidelines were met.
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- 2019
43. Reducing postoperative catheterisation after anterior colporrhaphy from 48 to 24 h: a randomised controlled trial
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Fernandez-Gonzalez S, Martínez Franco E, Martínez-Cumplido R, Molinet Coll C, Ojeda González F, Gómez-Roig MD, and Amat Tardiu L
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Postoperative catheterization ,Anterior colporrhaphy ,Postoperative urinary retention - Abstract
INTRODUCTION AND HYPOTHESIS: There is a distinct lack of literature on postoperative management after anterior colporrhaphy (AC). Our traditional postoperative protocol consisted of 24 h of indwelling catheterisation followed by 24 h of self-intermittent catheterisation. We hypothesised that a new protocol consisting of only 24 h of indwelling catheterisation might produce better results without additional complications. METHODS: From April 2014 to July 2017, all candidates for AC were randomised to catheter removal 24 or 48 h after surgery. The primary outcome was the postoperative urinary retention (POUR) rate. Secondary outcomes included: asymptomatic bacteriuria (AB), urinary tract infection (UTI) and postoperative pain after 24 h. RESULTS: A total of 79 patients were recruited. Thirty-seven and 40 patients were randomised to follow the 48-h protocol and the 24-h protocol respectively. There were no significant differences in relation to the POUR rate: 3 patients (8.1%) vs 1 (2.5%) in the 48-h vs the 24-h group respectively (p = 0.346). The UTI rate was 2 (8.1%) vs 0 patients respectively (p = 0.139) and the postoperative AB rate was 3 (9.1%) vs 0 patients (p = 0.106). In the postoperative pain evaluation, the visual analogue scale score was significantly higher in the 48 h group (0.35 vs 0.13, p = 0.02). CONCLUSIONS: According to our results, reducing the catheterisation from 48 to 24 h after AC does not increase the risk of POUR and decreases the rate of UTI, AB and postoperative pain. This new postoperative management protocol of pelvic floor surgery would improve postoperative outcomes and shorten the stay in hospital.
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- 2019
44. Reader Arquitecture Characterization for Chipless Wireless Sensors Applications
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Villa-González, F. (Fátima) and Valderas Gazquez, D.(Daniel)
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The main goal of this project is to design, implement and characterize a portable chipless reader for resonator chipless tags by comparing it with a non-portable chipless reader. In laboratory settings, test equipment such as Vector Network Analyzers (VNAs), Signal Analyzers and Digital Storage Oscilloscopes (DSO) are used. However, it is not economical to use these expensive and heavy laboratory pieces of equipment for the real-world applications of chipless RFID systems. Therefore, apart from reducing the cost by using chipless technologies, it is essential to develop a low-cost reader device that makes the system even more inexpensive. This is basically done by replacing the large and bulky equipment with some commercial components that make the device light and portable. Concretely, the design of the reader presented in this document, implements a Wideband Synthesizer with Integrated VCO in order to replace the Signal Generator. The most challenging task is the correct synchronization of the new device with the rest of the elements of the reader. This is achieved by a new computer software specifically programmed to control the whole reader, which is based on a previous version. The system’s performance is tested with several chipless tags; resonators with different resonance frequencies. The obtained results are compared to the measurements taken with a VNA and with a previous version of the reader composed by laboratory instruments. The measurements are made with a gain/phase detector that sends its data to an Arduino. Moreover, the information is processed by a Visual Studio project written in C Language that also contains the software with the user interface to control the synthesizer from the computer and all the data processing and visualization algorithms. The aim of the project is to describe the characterization of a reader based on frequency domain detection techniques and obtain the most accurate and effective performance of it to improve the previous version of the system and approach to an applicable device.
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- 2019
45. Objectives and methodology of BIOBADASER phase iii
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Sanchez-Piedra C, Hernández Miguel MV, Manero J, Roselló R, Sánchez-Costa JT, Rodríguez-Lozano C, Campos C, Cuende E, Fernández-Lopez JC, Bustabad S, Martín Domenech R, Pérez-Pampín E, Del Pino-Montes J, Millan-Arciniegas AM, Díaz-González F, Gómez-Reino JJ, and en representación del Grupo de trabajo BIOBADASER Fase III
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Terapia biológica ,Adverse events ,Methods ,Real World Data ,Biological therapy ,Acontecimientos adversos ,Artritis reumatoide ,Rheumatoid arthritis ,Safety ,Metodología ,Seguridad - Abstract
OBJECTIVE: Describe the objectives, methods and results of the first year of the new version of the Spanish registry of adverse events involving biological therapies and synthetic drugs with an identifiable target in rheumatic diseases (BIOBADASER III). METHODOLOGY: Multicenter prospective registry of patients with rheumatic inflammatory diseases being treated with biological drugs or synthetic drugs with an identifiable target in rheumatology departments in Spain. The main objective of BIOBADASER Phase III is the registry and analysis of adverse events; moreover, a secondary objective was added consisting of assessing the effectiveness by means of the registry of activity indexes. Patients in the registry are evaluated at least once every year and whenever they experience an adverse event or a change in treatment. The collection of data for phase iii began on 17 December 2015. RESULTS: During the first year, 35 centers participated. The number of patients included in this new phase in December 2016 was 2,664. The mean age was 53.7 years and the median duration of treatment was 8.1 years. In all, 40.4% of the patients were diagnosed with rheumatoid arthritis. The most frequent adverse events were infections and infestations. CONCLUSIONS: BIOBADASER Phase III has been launched to adapt to a changing pharmacological environment, with the introduction of biosimilars and small molecules in the treatment of rheumatic diseases. This new stage is adapted to the changes in the reporting of adverse events and now includes information related to activity scores.
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- 2019
46. Onicomicosis en pediatría: Actualización y tratamiento
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Daniela A. Alfaro S. and Carmen Gloria González F
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medicine.medical_specialty ,Diagnostic methods ,business.industry ,tiña ,MEDLINE ,Treatment options ,Safety profile ,pediatría ,Pediatrics, Perinatology and Child Health ,Epidemiology ,medicine ,dermatofitos ,uña ,onicomicosis ,business ,Intensive care medicine ,Pediatric population - Abstract
La onicomicosis (OM) es una infección fúngica de las uñas, cuyo principal agente causal es el Tricophytum rubrum. Si bien es una patología infrecuente en niños, se ha observado un aumento en la prevalencia en el último tiempo. Hasta la fecha, existen diversos estudios y guías clínicas de OM en adultos. Sin embargo, la literatura en edad pediátrica es escasa, lo que dificulta el tratamiento en pediatría. En el presente articulo se revisa la literatura actual, los métodos diagnosticos de OM, datos epidemiológicos locales y globales, y se presentan las opciones de tratamiento disponibles considerando su eficacia y perfil de seguridad en población pediátrica.
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- 2020
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47. Control biológico de fitopatógenos, insectos y ácaros: Agentes de control biológico (Volumen 1)
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Liz Alejandra Uribe Gutiérrez, Takumasa Kondo, Diego Fernando Rincón, Wagner Bettiol, María Victoria Zuluaga Mogollón, Xavier Fargetton, María del Rosario Manzano Martínez, Miguel López Ferber, María Fernanda Díaz Niño, Sébastien Massart, Aymer Andrés Vásquez Ordóñez, Felipe Borrero Echeverry, Hugo Fernando Rivera Trujillo, Martha Isabel Gómez Álvarez, Martha Liliana Rodríguez, Fabiola Moreno, Alex Enrique Bustillo Pardey, Nancy del Carmen Barreto Triana, Diana Marcela León, Guillermo Adolfo León Martínez, Bernhard Leo Lohr, Yimmy Alexander Zapata Narváez, Mariano Nicolás Belaich, Carlos Andrés Moreno Velandia, Andrés Díaz García, Manuel Ricardo Pérez, Yigal Elad, Ángela María Arcila Cardona, Eduardo María Espitia Malagón, John Fredy Hernández Nopsa, Pablo Daniel Ghiringhelli, Michael Wisniewski, Lissette Aracely Torres Torres, Sandra Milena Aragón Rodríguez, Luz Astrid Pulido, Leonardo Solorzano Buitrago, Mark Hurst, Jorge Ibarra, Adriana Marcela Santos Díaz, Kornelia Smalla, Fredy Mauricio Cruz Barrera, Laura Fernanda Villamizar, Jürgen Köhl, Ruth Análida Betancourt, Caroline de Clerck, Gabriele Berg, Sadao Kobayashi, Alexander Escobar, Alicia Balbin, Germán Vargas, Stephen Lewis Mosher, Érika Andrea Alarcón Torres, Yohana Alexandra Martínez, Arturo Carabalí Muñoz, Alba Marina Cotes Prado, Cam Oehlschlager, Alejandro Caro Quintero, Juliana Andrea Gómez Valderrama, Camilo Rubén Beltrán Acosta, Carlos Espinel Correal, Casey W. Hoy, Consuelo Alexandra Narváez Vásquez, Carolina González Almario, Gloria Patricia Barrera Cubillos, María Isabel Gómez Jiménez, Trevor Jackson, Guillermo González F., Haissam Jijakil, Érika Paola Grijalba, Paola Emilia Cuartas, and Juan Luis Jurat Fuentes
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Biology - Published
- 2018
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48. Study of a chemo-repulsion model with quadratic production. Part II: Analysis of an unconditional energy-stable fully discrete scheme
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Guillén-González, F., Rodríguez-Bellido, M. A., and Rueda-Gómez, D. A.
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FOS: Mathematics ,35K51, 35Q92, 65M12, 65M15, 65M60, 92C17 ,Mathematics - Numerical Analysis ,Numerical Analysis (math.NA) - Abstract
This work is devoted to the study of a fully discrete scheme for a repulsive chemotaxis with quadratic production model. By following the ideas presented in [Guilen-Gonzalez et al], we introduce an auxiliary variable (the gradient of the chemical concentration), and prove that the corresponding Finite Element (FE) backward Euler scheme is conservative and unconditionally energy-stable. Additionally, we also study some properties like solvability, a priori estimates, convergence towards weak solutions and error estimates. On the other hand, we propose two linear iterative methods to approach the nonlinear scheme: an energy-stable Picard method and Newton's method. We prove solvability and convergence of both methods towards the nonlinear scheme. Finally, we provide some numerical results in agreement with our theoretical analysis with respect to the error estimates.
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- 2018
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49. Resonancia magnética cardíaca en el seguimiento alejado de pacientes con tetralogía de Fallot
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Rodrigo González F, Paulo Valderrama E., Lida Toro R., Rodrigo Parra R, Gonzalo Urcelay M, Pedro Becker R, and Ma. Francisca Arancibia G.
- Subjects
medicine.medical_specialty ,Ejection fraction ,medicine.diagnostic_test ,insuficiencia pulmonar ,business.industry ,Tetralogía de Fallot ,Magnetic resonance imaging ,medicine.disease ,medicine.anatomical_structure ,parche transanular ,Ventricle ,resonancia magnética cardiaca ,Internal medicine ,Pulmonary Valve Replacement ,Pediatrics, Perinatology and Child Health ,Regurgitant fraction ,cardiovascular system ,Cardiology ,Medicine ,cardiovascular diseases ,Transannular patch ,business ,Cardiac magnetic resonance ,volumen de fin de diástole ,Tetralogy of Fallot - Abstract
Resumen: Introducción: La tetralogía de Fallot (TF) es la cardiopatía congénita cianótica más frecuente. La insuficiencia pulmonar (IP) y dilatación del ventrículo derecho (VD) son las complicaciones más fre cuentes a largo plazo. La resonancia magnética cardiaca (RMC) es el “gold standard” para la evalua ción del VD. Objetivo: Analizar la información obtenida de las RMC en el seguimiento de pacientes con TF. Pacientes y Método: Se incluyeron RMC realizadas entre 2007 y 2012 a pacientes con TF, reparados con parche transanular (PTA) o ampliación infundibular (AInf) y sin recambio valvular pulmonar (RVP). La fracción de regurgitación pulmonar (FRP), el volumen y función ventricular fueron evaluados. Resultados: Se realizaron 122 RMC a 114 pacientes. Edad promedio al examen 15,4 ± 7,4 años. 53,3% presentó IP severa (> 40%). La media del volumen de fin de diástole del VD (VFDVD) fue 157,3 ± 38,6 ml/m2, fin de sístole (VFSVD) de 85,3 ± 27 ml/m2 y fracción de eyección (FEVD) 46,4 ± 7,1%. 48,4% presentaba un VFDVD mayor de 150 ml/m2 y el 32,8% mayor a 170 ml/ m2. El PTA se relacionó con mayores volúmenes de VD que la AInf. VFDVD mayor a 170 ml/m2 mos traron peor FEVD (FEVD 47,9 ± 7% vs 43,2 ± 6,4%, p < 0,01). Discusión: Casi la mitad mostró una significativa dilatación del VD demostrando que la indicación de RMC es tardía en el seguimiento. El PTA se asoció con mayores VFDVD y VFSVD pero no a peor FEVD.
- Published
- 2018
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50. [Cardiac Magnetic Resonance in long term follow-up of Tetralogy of Fallot]
- Author
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Ma Francisca, Arancibia G, Paulo, Valderrama E, Gonzalo, Urcelay M, Pedro, Becker R, Rodrigo, González F, Lida, Toro R, and Rodrigo, Parra R
- Subjects
Male ,Adolescent ,Hypertrophy, Right Ventricular ,Ventricular Dysfunction, Right ,Infant ,Magnetic Resonance Imaging ,Postoperative Complications ,Child, Preschool ,Tetralogy of Fallot ,Humans ,Female ,Child ,Follow-Up Studies ,Retrospective Studies - Abstract
Tetralogy of Fallot (TOF) is the most frequent cyanotic congenital heart disease. Pulmonary regurgitation (PR) and right ventricle (RV) enlargement and dysfunction are the most common long-term complications. Cardiac magnetic resonance (CMR) is the gold standard for RV evaluation.To analyze CMR results in the follow-up of TOF patients.All CMR performed between 2007 and 2012 in TOF patients with transannular patch (TAP) repair or infundibular widening, and without pulmonary valve replacement (PVR) were included. Pulmonary regurgitant fraction (PRF), ventricular end-diastolic (EDV) and end-systolic volume (ESV), and ejection fraction (EF) were examined.122 CMR were performed in 114 patients. Average age at CMR was 15.4±7.4 years. 53.3% of them presented severe PR (40%). RVEDV was 157.3 ± 38.6 ml/m2, RVESV was 85.3 ± 27 ml/m2 and RVEF was 46.4 ± 7.1%. RVEDV was150 ml/ m2 in 48.4% and170 ml/m2 in 32.8% of patients. Patients with TAP showed larger RV volumes compared with those with infundibular widening. RVEDV170 ml/m2 showed worse RVEF that those with lower RVEDV (47.9 ± 7% vs 43.2 ± 6.4%, p0.01).Almost half of the pa tients showed significant RV enlargement, demonstrating that the indication of CMR is late in their follow-up. TAP was associated with higher RVEDV and RVESV, but no worse RVEF.
- Published
- 2017
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