1. Clin Infect Dis
- Author
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Shepherd, L., Ryom, L., Law, M., Petoumenos, K., Hatleberg, C. I., D'Arminio Monforte, A., Sabin, C., Bower, M., Bonnet, F., Reiss, P., De Wit, S., Pradier, C., Weber, R., El-Sadr, W., Lundgren, J., Mocroft, A., the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study Group, Segala, Daniela, Global Health, Infectious diseases, AII - Infectious diseases, APH - Aging & Later Life, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
0301 basic medicine ,Microbiology (medical) ,Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,030106 microbiology ,Human immunodeficiency virus (HIV) ,HIV, smoking, smoking cessation, cancer ,HIV Infections ,medicine.disease_cause ,smoking ,NO ,FR ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Internal medicine ,Neoplasms ,medicine ,cancer ,MORPH3Eus ,Humans ,DAD ,030212 general & internal medicine ,Poisson regression ,Prospective Studies ,Lung cancer ,Adverse effect ,Aged ,Aged, 80 and over ,Lung ,business.industry ,Incidence (epidemiology) ,Incidence ,HIV ,Cancer ,Middle Aged ,medicine.disease ,3. Good health ,Infectious Diseases ,medicine.anatomical_structure ,symbols ,Smoking cessation ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,Smoking Cessation ,business - Abstract
Background Cancers are a major source of morbidity and mortality for HIV-positive persons on combination antiretroviral therapy, while the clinical benefits of smoking cessation are not well established. Methods Participants were followed from 1 January 2004 until first cancer diagnosis, death, or 1 February 2016. Smoking status was defined as ex ( 5 years since stopping), current, and never smokers. Outcomes considered were any cancer, lung cancer, other smoking-related excluding lung and smoking-unrelated cancers. Adjusted incidence rate ratios (aIRR) were calculated using Poisson regression, adjusting for demographic and clinical factors. Results 35442 persons from the D:A:D study contributed 309803 person years of follow-up. At baseline, 49% of people were current smokers, 21% were ex-smokers, 30% had never smoked. Incidence of all cancers combined (N=2183) was highest
- Published
- 2018
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