1. Anti-Ascaris immunoglobulin E associated with bronchial hyper-reactivity in 9-year-old rural Bangladeshi children
- Author
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Al Fazal Khan, Mohammad Yunus, Tsutomu Iwata, Shinji Nakahara, Mohammad Imrul Hasan, K. Zaman, Hafizur Rahman Chowdhury, Sayaka Takanashi, Hirotsugu Kano, Haruko Takeuchi, Yukiko Wagatsuma, and Mohammad Delwer Hossain Hawlader
- Subjects
Male ,Rural Population ,lcsh:Immunologic diseases. Allergy ,Allergy ,Antigen specific IgE ,Population ,Antibodies, Helminth ,Nematode infections ,Immunoglobulin E ,Bronchial Provocation Tests ,Childhood asthma ,Atopy ,03 medical and health sciences ,0302 clinical medicine ,Odds Ratio ,Animals ,Humans ,Medicine ,Immunology and Allergy ,Respiratory sounds ,Child ,education ,Respiratory Sounds ,Asthma ,Bangladesh ,education.field_of_study ,biology ,medicine.diagnostic_test ,business.industry ,Ascaris ,General Medicine ,Odds ratio ,Bronchial hyper-responsiveness ,biology.organism_classification ,medicine.disease ,Respiratory Function Tests ,030228 respiratory system ,Immunology ,Lung function tests ,biology.protein ,Female ,Bronchial Hyperreactivity ,business ,lcsh:RC581-607 ,030215 immunology - Abstract
Background: Studies have addressed the immunomodulatory effects of helminths and their protective effects upon asthma. However, anti-Ascaris IgE has been reported to be associated with an increased risk of asthma symptoms. We examined the association between serum levels of anti-Ascaris IgE and bronchial hyper-responsiveness (BHR) in children living in rural Bangladesh. Methods: Serum anti-Ascaris IgE level was measured and the BHR test done in 158 children aged 9 years selected randomly from a general population of 1705 in the Matlab Health and Demographic Surveillance Area of the International Centre for Diarrhoeal Disease Research, Bangladesh. We investigated wheezing symptoms using a questionnaire from the International Study of Asthma and Allergies in Childhood. BHR tests were successfully done on 152 children (108 ‘current wheezers’; 44 ‘never-wheezers’). We examined the association between anti-Ascaris IgE level and wheezing and BHR using multiple logistic regression analyses. Results: Of 108 current-wheezers, 59 were BHR-positive; of 44 never-wheezers, 32 were BHR-negative. Mean anti-Ascaris IgE levels were significantly higher (12.51 UA/ml; 95% confidence interval (CI), 9.21–17.00) in children with current wheezing with BHR-positive than in those of never-wheezers with BHR-negative (3.89; 2.65–5.70; t test, p
- Published
- 2016
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