1. Comparison of hemodynamic changes after repetitive transcranial magnetic stimulation over the anatomical hand knob and hand motor hotspot: A functional near-infrared spectroscopy study
- Author
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Won Hyuk Chang, Heegoo Kim, Hwang-Jae Lee, Jinuk Kim, Jung-Soo Lee, Yun-Hee Kim, and Yoonju Na
- Subjects
Serial reaction time ,Adult ,Male ,medicine.medical_specialty ,Modulation effect ,medicine.medical_treatment ,hand knob ,Hemodynamics ,Stimulation ,Interhemispheric modulation ,behavioral disciplines and activities ,hand motor hot spot ,050105 experimental psychology ,03 medical and health sciences ,0302 clinical medicine ,Developmental Neuroscience ,Near-infrared spectroscopy ,Internal medicine ,mental disorders ,Medicine ,Humans ,0501 psychology and cognitive sciences ,Single-Blind Method ,Cross-Over Studies ,Spectroscopy, Near-Infrared ,business.industry ,musculoskeletal, neural, and ocular physiology ,05 social sciences ,Contralateral hemisphere ,Motor Cortex ,Evoked Potentials, Motor ,Hand ,Transcranial Magnetic Stimulation ,Transcranial magnetic stimulation ,medicine.anatomical_structure ,Neurology ,nervous system ,Cardiology ,Functional near-infrared spectroscopy ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,psychological phenomena and processes ,Motor cortex ,Research Article - Abstract
Background: Low-frequency rTMS can induce upregulation of excitability in the contralateral hemisphere by interhemispheric interaction. Objective: The aim of this study was to compare the effects of interhemispheric modulation on hemodynamic changes after applying low-frequency rTMS over the anatomical hand knob (HK) and the hand motor hotspot (hMHS) in the dominant motor cortex. Methods: Ten healthy right-handed participants without a history of neurological or psychiatric symptoms (five males; 29.8±2.8 years) participated in this single-blind, randomized, cross-over study. rTMS was applied under three conditions over the dominant (left) hemisphere for 20 minutes: 1) 1 Hz rTMS stimulation on the HK (HK-rTMS), 2) 1 Hz rTMS stimulation on the hMHS (hMHS-rTMS), and 3) sham stimulation (Sham-rTMS). For all participants, functional near-infrared spectroscopy (fNIRS) was applied for measurement of cerebral oxyhemoglobin (oxyHb) and deoxyhemoglobin (deoxyHb) concentration over the non-dominant (right) hemisphere during a serial reaction time task (SRTT) with the non-dominant (left) hand before and after each condition. Results: The average coordinates of the hMHS (x = – 39.60 mm, y = – 17.11 mm, z = 66.40 mm) were anterior and lateral to the HK (x = – 36.72 mm, y = – 28.87 mm, z = 56.41 mm). In fNIRS time-series analysis, the integral value of oxyHb was significantly increased over the motor cortical region of the non-dominant hemisphere after the hMHS-rTMS compared with Sham-rTMS. The HK-rTMS also showed slight increment of oxyHb concentration but without statistical significance. The SPM group analysis showed greater magnitude of the activity in hMHS-rTMS than that of HK-rTMS after stimulation (p
- Published
- 2020