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2 results on '"Katrzyna Jaworska-Bieniek"'

1. Meeting abstracts from the Annual Conference on Hereditary Cancers 2016

Author

Asta Försti, E. N. Imyanitov, Tomasz Gromowski, Kari Hemminki, Jakub Lubiński, E. Marczyk, O. Aszurek, Oleg Oszurek, R. Sibilski, A. Loya, Wojciech Kluźniak, M. R. Akbari, M. Szwiec, M. Falco, H. Rudnicka, Jacek Gronwald, M. Siołek, B. Kozak-Klonowska, Tomasz Byrski, Ping Sun, N. Muhammad, N. Peruga, T. Mierzwa, R. Billings, Bohdan Górski, Tadeusz Dębniak, Wojciech Marciniak, Józef Kładny, A. Savanevich, S. G. Braye, V. Sopik, A. Mathe, Katarzyna Durda, Cezary Cybulski, R. Wiśniowski, S. Pietrzak, A. Wiechowska-Kozłowska, J. F. Forbes, E. Kilar, A. Morawski, Dagmara Dymerska, Andrzej Pławski, M. Wong-Brown, Grzegorz Kurzawski, M. A. Yusuf, Karolina Prajzendanc, Piotr Baszuk, Marcin Lener, Kelly A. Avery-Kiejda, Krystian Kaczmarek, M. Stawicka, K. Gugała, Z. Morawiec, M. Kuswik, S. Clark, A. Soluch, Piotr Waloszczyk, Rodney J. Scott, Katarzyna Paszkowska-Szczur, M. Posmyk, Steven A. Narod, M. Muszyńska, W. Locke, R. Posmyk, Katrzyna Jaworska-Bieniek, A Jakubowska, J. Jakubowicz, Grzegorz Sukiennicki, M. R. Lener, Dominika Wokołorczyk, K. Kąklewski, U. R. Rashid, C. Stirzaker, D. Surdyka, H. Naeemi, A. Kashyap, J. Tomiczek-Szwiec, Tomasz Huzarski, K. Tutlewska, Hanna Janiszewska, and P. Domagała

Subjects
medicine.medical_specialty, Oncology, business.industry, Family medicine, Medicine, business, Meeting Abstracts, Genetics (clinical), Human genetics
Published
2017
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2. Microelements as risk factors for cancer of the lung and larynx

Author

Anna Jakubowska, Katrzyna Jaworska-Bieniek, Katarzyna Durda, Marcin Lener, Jan Lubinski, Mieczysław Sulikowski, Grzegorz Sukiennicki, Satish Gupta, Magdalena Muszyńska, Tomasz Grodzki, Janusz Wójcik, Ping Sun, Tadeusz Dębniak, Jakub Lubiński, Cezary Cybulski, Piotr Woloszczyk, Elżbieta Jaworowska, and Steven A. Narod

Subjects
medicine.medical_specialty, GPX1, Pathology, Lung, lcsh:QH426-470, business.industry, Cancer, Odds ratio, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, lcsh:RC254-282, Gastroenterology, lcsh:Genetics, medicine.anatomical_structure, Oncology, Quartile, Selenium deficiency, Internal medicine, Meeting Abstract, Genotype, medicine, Lung cancer, business, Genetics (clinical)
Abstract

Selenium deficiency has been suggested by several studies to be associated with cancer risk. We conducted a case-control study in Szczecin, a region of northwestern Poland, on 86 cases of lung cancer, 87 cases of laryngeal cancer and an equal number of healthy controls. We studied the serum level of selenium and genotypes for four variants in four selenoprotein genes (GPX1, GPX4, TXNRD2 and SEP15) and the odds of being diagnosed with lung or laryngeal cancer. Among lung cancer cases, the mean selenium level was 63.2 µg/l, compared to a mean level of 74.7 µg/l for their matched controls (p 80 µg/l) was associated with an odds ratio of 0.10 (95% CI 0.03 to 0.34; p = 0.0002) for lung cancer and 0.24 (95% CI 0.10 to 0.59; p = 0.002) for laryngeal cancer. In four selenoproteins studied here we found a modest associations of genetic variants in GPX1 and GPX4 with lung and TXNRD2 with laryngeal cancer risk. We analyzed iron (Fe) level in serum of 77 lung cancer patients and 77 matched controls. We did not find difference in mean Fe level between cases and controls (1053.05 µg/l and 1059.39 µg/l). However, we found that Fe level in the lowest and highest quartiles was associated with a significant lung risk enhancement when compared to a serum Fe level in the middle quartiles (OR 0.3, p 0.02). We also observed that the relationship between the level of Fe and Se could be an important factor for lung cancer risk.

Published
2012
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