Search

Your search keyword '"Koller, M"' showing total 54 results
Start Over Author "Koller, M" Language undetermined
54 results on '"Koller, M"'

1. Polyhydroxyalkanoate (PHA) Bio-polyesters – Circular Materials for Sustainable Development and Growth

Author

Mukherjee, A. and Koller, M.

Subjects
Process Chemistry and Technology, General Chemistry, biopolymers, biodegradable polymers circular bioeconomy, circular materials, microbial biopolyesters, microplastics, polyhydroxyalkanoate, UN Sustainable Development goals, Biochemistry
Abstract

Achieving circularity in materials requires fundamental changes in the polymers we use today and the way they are produced. Functional polymeric materials from renewable feedstocks that do not conflict with food and animal feed, and their renewal through biodegradation under diverse environmental conditions as the desired end-of-life option indeed constitute a paradigm shift for today’s plastics industry. Considering the ever-increasing environmental problems associated with the disposal or incineration of fossil plastics, the increasing microplastic formation, food contamination, and rising atmospheric CO2 concentrations, have made it clear that the time is ripe for alternative, innovative, and sustainable polymers with plastic-like properties. In this nexus, the present review shines new light on the benefits of biobased and, at the same time, biodegradable microbial polyhydroxyalkanoate (PHA) biopolyesters. Special emphasis is dedicated to carbon recyclability through biodegradability and compostability of these fascinating natural materials, which are slowly but surely being commercialized as replacement for fossil plastics that are produced and disposed of in multi-million-ton scale annually, resulting in a growing environmental threat. This review highlights that end-of-life options of PHA are analogous or even superior to another well-known polymer from nature, cellulose, while PHA offer the additional attributes of plastics in use with tailor-made properties. Finally, the review demonstrates how PHA biopolyesters can contribute to reaching many of the heavily discussed and desired UN Sustainable Development Goals. This work is licensed under a Creative Commons Attribution 4.0 International License.

Published
2023
Full Text
View/download PDF

2. Treatment of end-stage peripheral artery disease by neuromodulation

Author

Cucuruz, B, Kopp, R, Hampe-Hecht, H, Andercou, O, Schierling, W, Pfister, K, Koller, M, Noppeney, T, University of Zurich, and Cucuruz, B

Subjects
Physiology, 2720 Hematology, Pain, 610 Medicine & health, 1314 Physiology, Hematology, Limb Salvage, 2705 Cardiology and Cardiovascular Medicine, Peripheral Arterial Disease, 2737 Physiology (medical), Treatment Outcome, Ischemia, 11548 Clinic for Vascular Surgery, Physiology (medical), Transcutaneous Electric Nerve Stimulation, Humans, Cardiology and Cardiovascular Medicine, Retrospective Studies
Abstract

BACKGROUND: Neuromodulation is a therapeutic option to improve limb salvage in end-stage peripheral arterial disease (PAD), but there is no consensus on its indication for spinal cord stimulation (SCS) in PAD patients. OBJECTIVE: The aim of this study was to present the outcome of end-stage PAD patients treated with SCS. METHODS: This study is a retrospective analysis based on a local prospective registry. Neuromodulation was performed if there was: 1) no revascularisation option, 2) no septicemia, 3) and Rutherford stage 4–6. The primary endpoint of the study was limb salvage. Secondary endpoints were reduction in pain or simply pain reduction pain (assessed using a visual anlog scale/VAS) and improvement in walking distance. RESULTS: Limb salvage was reached in 30/34 patients (88%). Patients reported a significant reduction in pain on the 10-point VAS scale from baseline (median = 7.5, IQR = 7–8) to follow-up at 2 years (median = 0, IQR 0–2.75), p

Published
2022

3. Centralized Learning of the Distributed Downlink Channel Estimators in FDD Systems using Uplink Data

Author

Fesl, B., Turan, N., Koller, M., Joham, M., and Utschick, W.

Subjects
Signal Processing (eess.SP), FOS: Computer and information sciences, Computer Science - Information Theory, Information Theory (cs.IT), FOS: Electrical engineering, electronic engineering, information engineering, Electrical Engineering and Systems Science - Signal Processing
Abstract

In this work, we propose a convolutional neural network (CNN) based low-complexity approach for downlink (DL) channel estimation (CE) in frequency division duplex (FDD) systems. In contrast to existing work, we use training data which solely stems from the uplink (UL) domain. This allows to learn the CNN centralized at the base station (BS). After training, the network parameters are offloaded to mobile terminals (MTs) within the coverage area of the BS. The MTs can then obtain channel state information (CSI) of the MIMO channels with the low-complexity CNN estimator. This circumvents the necessity of an infeasible amount of feedback, i.e., acquisition of training data at the user, and the offline training phase at each MT. Numerical results show that the CNN which is trained solely based on UL data performs equally well as the network trained based on DL data. Furthermore, the approach is able to outperform state-of-the-art CE algorithms.

Published
2021
Full Text
View/download PDF

4. A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data

Author

Pagano, G, Boess, FG, Taylor, KI, Ricci, B, Mollenhauer, B, Poewe, W, Boulay, A, Anzures-Cabrera, J, Vogt, A, Marchesi, M, Post, A, Nikolcheva, T, Kinney, GG, Zago, WM, Ness, DK, Svoboda, H, Britschgi, M, Ostrowitzki, S, Simuni, T, Marek, K, Koller, M, Sevigny, J, Doody, R, Fontoura, P, Umbricht, D, Bonni, A, PASADENA Investigators, Bejr-Kasem, H, Bojarsky J.K., and Prasinezumab Study Grp

Subjects
disease modification treatments, disease progression, prasinezumab, Parkinson's disease, alpha-synuclein (alpha-syn), monoclonal antibodies, MDS-UPDRS = Movement Disorder Society-Unified Parkinson's Disease Rating Scale, Phase II clinical trial
Abstract

Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease. Objective: The study objective was to evaluate the efficacy and safety of prasinezumab, a humanized monoclonal antibody that binds aggregated alpha-synuclein, in individuals with early PD. Methods: The PASADENA study is a multicenter, randomized, double-blind, placebo-controlled treatment study. Individuals with early PD, recruited across the US and Europe, received monthly intravenous doses of prasinezumab (1,500 or 4,500 mg) or placebo for a 52-week period (Part 1), followed by a 52-week extension (Part 2) in which all participants received active treatment. Key inclusion criteria were: aged 40-80 years; Hoehn & Yahr (H&Y) Stage I or II; time from diagnosis Results: Of the 443 patients screened, 316 were enrolled into the PASADENA study between June 2017 and November 2018, with an average age of 59.9 years and 67.4% being male. Mean time from diagnosis at baseline was 10.11 months, with 75.3% in H&Y Stage II. Baseline motor and non-motor symptoms (assessed using Movement Disorder Society-Unified Parkinson's Disease Rating Scale [MDS-UPDRS]) were similar in severity between the MAO-B inhibitor-treated and treatment-naive PASADENA cohorts (MDS-UPDRS sum of Parts I + II + III [standard deviation (SD)]; 30.21 [11.96], 32.10 [13.20], respectively). The overall PASADENA population (63.6% treatment naive and 36.4% on MAO-B inhibitor) showed a similar severity in MDS-UPDRS scores (e.g., MDS-UPDRS sum of Parts I + II + III [SD]; 31.41 [12.78], 32.63 [13.04], respectively) to the PPMI cohort (all treatment naive). Conclusions: The PASADENA study population is suitable to investigate the potential of prasinezumab to slow disease progression in individuals with early PD.

Published
2021

5. Evaluation of thoracic impedance trends for implant-based remote monitoring in heart failure patients - Results from the (J-)HomeCARE-II Study

Author

Maier S, Paule S, Jung W, Koller M, Ventura R, Quesada A, Bordachar P, Garcia-Fernandez F, Schumacher B, Lobitz N, Takizawa K, Ando K, Adachi K, and Shoda M

Abstract

Aims: Remote monitoring by implantable devices substantially improves management of heart failure (HF) patients by providing diagnostic day-to-day data. The use of thoracic impedance (TI) as a surrogate measure of fluid accumulation is still strongly debated. The multicenter HomeCARE-II study evaluated clinically apparent HF events in the context of remote device diagnostics, focusing on the controversial role of TI. Methods and results: We followed 497 patients (66.6 +/- 10.1 years, 77% male, QRS 139.8 +/- 36.0 ms, ejection fraction 26.8 +/- 7.0%) implanted with a CRT-D (67%) or an ICD (33%) for 21.4 +/- 8.1 months. An independent event committee confirmed 171 HF events of which 82 were used to develop a TI-based algorithm for the prediction of imminent cardiac decompensation. Highly inter-individual variations in patterns of TI trends were observed. The algorithm resulted in a sensitivity of 41.5% (50.0%) with 0.95 (1.34) false alerts per patient year, and a positive predictive value of 7.9% overall and 27.9% in the HF event group of patients. Averaged ratio statistics showed a significant pre-hospital decrease and a highly significant in-hospital increase in TI after intensified diuresis. Recurrent decompensations turned out to be preceded by a significantly stronger decrease of TI compared to first events with a higher chance for detection (63.6% sensitivity, p < 0.05). Conclusions: Overall performance in predicting imminent decompensation by monitoring TI alone is limited due to its high inter-patient variability. TI stand-alone applications should be redirected towards a target population with more advanced symptoms where post-hospital observation aimed to maintain the patient's discharge status might be the most valuable approach. (C) 2019 Elsevier Inc All rights reserved.

Published
2019

8. Clostridium difficile infection is associated with graft loss in solid organ transplant recipients

Author

Cusini, A, Béguelin, C, Stampf, S, Boggian, K, Garzoni, C, Koller, M, Manuel, O, Meylan, P, Mueller, NJ, Hirsch, HH, Weisser, M, Berger, C, van Delden, C, Achermann, R, Amico, P, Aubert, JD, Banz, V, Beldi, G, Benden, C, Binet, I, Bochud, PY, Bucher, H, Bühler, L, Carell, T, Catana, E, Chalandon, Y, de Geest, S, de Rougemont, O, Dickenmann, M, Duchosal, M, Elkrief, L, Fehr, T, Ferrari-Lacraz, S, Gasche Soccal, P, Gaudet, C, Giostra, E, Golshayan, D, Hadaya, K, Halter, J, Heim, D, Hess, C, Hillinger, S, Hofbauer, G, Huynh-Do, U, Immer, F, Klaghofer, R, Laesser, B, Lehmann, R, Lovis, C, Marti, HP, Martin, PY, Mohacsi, P, Morel, P, Mueller, U, Mueller-McKenna, H, Müller, A, Müller, T, Müllhaupt, B, Nadal, D, Pascual, M, Passweg, J, Rick, J, Roosnek, E, Rosselet, A, Rothlin, S, Ruschitzka, F, Schanz, U, Schaub, S, Schnyder, A, Seiler, C, Steiger, J, Stirnimann, G, Toso, C, Venetz, JP, Villard, J, Wick, M, Wilhelm, M, Yerly, P, Gasche-Soccal, Paola Marina Alessandra, University of Zurich, and van Delden, C

Subjects
Graft Rejection, Male, genetic structures, 2747 Transplantation, 10265 Clinic for Endocrinology and Diabetology, 030230 surgery, 10234 Clinic for Infectious Diseases, 0302 clinical medicine, Postoperative Complications, Risk Factors, Medicine, 2736 Pharmacology (medical), Immunology and Allergy, Pharmacology (medical), 030212 general & internal medicine, Prospective Studies, 610 Medicine & health, Prospective cohort study, ddc:616, Incidence, Hazard ratio, Graft Survival, Clostridium difficile, Middle Aged, Prognosis, Anti-Bacterial Agents, Diarrhea, 10209 Clinic for Cardiology, 2723 Immunology and Allergy, Female, medicine.symptom, 10178 Clinic for Pneumology, Switzerland, Cohort study, medicine.medical_specialty, 03 medical and health sciences, Internal medicine, Humans, Transplantation, business.industry, Clostridioides difficile, Case-control study, Organ Transplantation, Confidence interval, Transplant Recipients, 10036 Medical Clinic, Case-Control Studies, Clostridium Infections, business, Follow-Up Studies
Abstract

© 2018 The American Society of Transplantation and the American Society of Transplant Surgeons Clostridium difficile infection (CDI) is a leading cause of infectious diarrhea in solid organ transplant recipients (SOT). We aimed to assess incidence, risk factors, and outcome of CDI within the Swiss Transplant Cohort Study (STCS). We performed a case-control study of SOT recipients in the STCS diagnosed with CDI between May 2008 and August 2013. We matched 2 control subjects per case by age at transplantation, sex, and transplanted organ. A multivariable analysis was performed using conditional logistic regression to identify risk factors and evaluate outcome of CDI. Two thousand one hundred fifty-eight SOT recipients, comprising 87 cases of CDI and 174 matched controls were included. The overall CDI rate per 10 000 patient days was 0.47 (95% confidence interval ([CI] 0.38-0.58), with the highest rate in lung (1.48, 95% CI 0.93-2.24). In multivariable analysis, proven infections (hazard ratio [HR] 2.82, 95% CI 1.29-6.19) and antibiotic treatments (HR 4.51, 95% CI 2.03-10.0) during the preceding 3 months were independently associated with the development of CDI. Despite mild clinical presentations, recipients acquiring CDI posttransplantation had an increased risk of graft loss (HR 2.24, 95% CI 1.15-4.37; P =.02). These findings may help to improve the management of SOT recipients. ispartof: American Journal of Transplantation vol:18 issue:7 pages:1745-1754 ispartof: location:United States status: published

Published
2017

9. Development of a disease-specific quality of life questionnaire module for patients with gastrointestinal neuroendocrine tumours

Author

Davies, A. H. G., Larsson, G., Ardill, J., Friend, E., Jones, L., Falconi, Massimo, Bettini, Rossella, Koller, M., Sezer, O., Fleissner, C., Taal, B., Blazeby, J. M., Ramage, J. K., Quality of Life Group, E. O. R. T. C., A. H. G., Davie, G., Larsson, J., Ardill, E., Friend, L., Jone, Falconi, Massimo, R., Bettini, M., Koller, O., Sezer, C., Fleissner, B., Taal, J. M., Blazeby, J. K., Ramage, and E. O. R. T. C., Quality of Life Group

Subjects
Adult, Male, Questionnaires, Disease specific, Cancer Research, medicine.medical_specialty, Adolescent, Psychometrics, MEDLINE, Neuroendocrine tumors, Sensitivity and Specificity, Quality of life, Surveys and Questionnaires, Health care, 80 and over, medicine, Humans, Aged, Gastrointestinal Neoplasms, Aged, 80 and over, business.industry, Cancer, social sciences, Middle Aged, medicine.disease, humanities, Surgery, Clinical trial, Neuroendocrine Tumors, Oncology, Family medicine, Quality of Life, Female, business
Abstract

Quality of life (QoL) measurements are increasingly being used as an end point in cancer clinical trials. Standard generic QoL questionnaires may not assess symptoms produced by neuroendocrine tumours. Here we report the development of a disease-specific quality of life score questionnaire for patients with neuroendocrine tumours of the gut to supplement the EORTC core cancer questionnaire, the QLQ-C30. Phases 1-3 of the EORTC quality of life group guidelines for module development were used to design the new questionnaire. Forty-one relevant issues (questions) were generated after an extensive literature search. Following interviews of 15 health care workers and 35 patients, a 35 question provisional questionnaire was constructed. This was translated into seven European languages and pre-tested in 180 patients resulting in a 21-item module that will be validated in an international clinical trial. The EORTC QLQ-NET21 provides a site-specific module to supplement the QLQ-C30 for patients with neuroendocrine tumours.

Published
2006
Full Text
View/download PDF

10. Pulmonale Rehabilitation bei COPD in der Schweiz – eine Standortbestimmung

Author

Johann Steurer, Otto Brändli, Milo A. Puhan, and Koller M

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Physical therapy, medicine, Pulmonary rehabilitation, General Medicine, Outcome assessment, business, Outcome parameter
Abstract

Le but était de caractériser des programmes de réadaptation respiratoire pour des patients avec BPCO en Suisse. 94% des questionnaires ont été retournés. En 2001, 2238 patients avec BPCO ont suivi un programme de réadaptation respiratoire en milieu hospitalier (1790) ou ambulatoire (448). Ceci correspond à 1% de tous les patients avec BPCO en Suisse. L'exercice physique a été estimé significativement plus important comparé aux exercices de respiration et à l'éducation du patient. L'introduction d'un instrument pour mesurer la qualité de vie représente la mesure la plus importante pour les patients avec BPCO. Ainsi, les composants des programmes de réadaptation et des facteurs prédictifs pourraient être evalués.

Published
2003
Full Text
View/download PDF

12. Economies of scale and scope and opening hours in post offices and agencies

Author

Massimo Filippini, Koller, M., Trinkner, U., University of Zurich, Crew, M A, Kleindorfer, P R, and Filippini, M

Subjects
2000 General Economics, Econometrics and Finance, 10004 Department of Business Administration, Economics and Finance, GeneralLiterature_MISCELLANEOUS, 330 Economics
Abstract

This compilation of original essays by an international cast of top scholars addresses some of the major issues now facing postal and delivery services throughout the world. The European Commission and member states wrestle with the problem of how to implement the scheduled liberalization of these sectors and maintain the universal service obligation while the United States Postal Service is coming to terms with the Postal Accountability and Enhancement Act. In addition, the book addresses the impact of electronic competition as well as other problems facing the field.

Published
2010
Full Text
View/download PDF

16. Homogeneous Data Set of Noise and Earthquake Recordings at Many Sites

Author

Atakan K., Azzara R., Bard P-Y., Cara F., Cultrera G., Daminelli R., Dimitriou P., Duval A-M., Faeh D., Giulio G., Hagshenas E., Havskov J., Koller M., Marcellini A., Pagani M., Panou A., Papaioannou C., Rovelli A., Savvaidis A., Spohler E., and Tento A. et A

Published
2003

18. THE CONSTRUCTION OF THE L3 EXPERIMENT

Author

Adeva, B, Aguilarbenitez, M, Akbari, H, Alcaraz, J, Aloisio, A, Alvareztaviel, J, Alverson, G, Alviggi, Mg, Anderhub, H, Anderson, Al, Angelov, Am, Angelov, Th, Antchev, Gh, Antonov, L, Antreasyan, D, Arefiev, A, Atanasov, Ih, Auroy, B, Ayad, R, Ayranov, Ol, Azemoon, T, Aziz, T, Bachmann, U, Bahler, P, Bakken, Ja, Baksay, L, Baldinger, H, Ball, Rc, Ballansat, J, Banerjee, S, Bao, J, Barbier, G, Barone, L, Basti, G, Bay, A, Beauvais, F, Becker, U, Beissel, R, Bendig, S, Bene, P, Berdugo, J, Berges, P, Berthet, M, Bertsch, Y, Betev, Bl, Biland, A, Bischoff, A, Bischops, M, Bizzarri, R, Blaising, Jj, Blanc, M, Blomeke, P, Blumenfeld, B, Bobbink, Gj, Bocciolini, M, Boffin, Kd, Bohlen, W, Bohm, A, Bohringer, T, Bonnefon, H, Bopp, C, Borgia, B, Bosseler, K, Bottolier, Jf, Bourquin, M, Boutigny, D, Bowditch, P, Branson, Jg, Braun, D, Brock, Jc, Bruyant, F, Buchholz, M, Bucken, B, Bulgeroni, W, Burel, R, Burger, Jd, Burgos, C, Burq, Jp, Caiazzo, L, Caillat, M, Camberlin, B, Campana, D, Camps, C, Canale, V, Capell, M, Carbonara, F, Carminati, F, Cartacci, Am, Cerrada, M, Cesaroni, F, Chang, Yh, Chapman, Jw, Chemarin, M, Chen, A, Chen, C, Chen, Hf, Chen, Hs, Chen, M, Chen, Ml, Chendvankar, Sr, Chevenier, G, Chidzik, S, Chiefari, G, Chien, Cy, Chollet, F, Chumakov, M, Civinini, C, Clare, I, Clare, R, Coignet, G, Colino, N, Commichau, V, Conforto, G, Cristofori, P, Crijns, F, Cui, Xy, Dai, Ts, Dalessandro, R, Daniel, M, Debouard, X, Debye, B, Decreuse, G, Degre, A, Deiters, K, Denes, E, Denes, P, Denotaristefani, F, Deutschmann, M, Dhina, M, Didierjean, B, Diemoz, M, Dietrich, M, Dimitrov, Ha, Dionisi, C, Dittus, F, Dohmen, M, Dolin, R, Donahue, Jf, Donat, A, Drago, E, Dreger, Kh, Driever, T, Dromby, G, Duinker, P, Duran, I, Elkacimi, M, Elmamouni, H, Engler, A, Eppling, Fj, Erne, Fc, Erne, I, Esser, H, Extermann, P, Fabbretti, R, Faber, G, Falciano, S, Falk, T, Fan, Sj, Favre, M, Fay, J, Feher, S, Fehlmann, J, Feldmann, M, Fenker, H, Ferguson, T, Fernandez, M, Ferroni, Fernando, Fesefeldt, H, Field, J, Figarola, Jm, Figueroa, Cf, Filipov, Ga, Foligne, B, Forconi, G, Foreman, T, Franzke, V, Frei, W, Freudenreich, K, Friebel, W, Fukushima, M, Gaillard, G, Gailloud, M, Galaktionov, Y, Gallo, E, Ganguli, Sn, Garelick, D, Gau, Ss, Gavrilov, G, Gennari, E, Gentile, Simonetta, Gettner, M, Girard, C, Glaubman, M, Goldfarb, S, Gong, Zf, Gonzalez, E, Gordeev, A, Gorodkov, Y, Gottlicher, P, Goy, C, Goyot, M, Gratta, G, Grimes, A, Grinnell, C, Gruenewald, M, Guanziroli, M, Guerra, S, Guillon, C, Gurtu, A, Gusewell, D, Gustafson, Hr, Haensli, M, Haan, M, Haller, C, Hamacher, T, Hammers, H, Hangarter, K, Hancke, S, Harris, M, Harting, D, Hartjes, Fg, He, Cf, Heavey, A, Hebbeker, T, Hebert, M, Heller, R, Helmrath, C, Herrmann, J, Herten, G, Herten, U, Herve, A, Hesser, H, Hilgers, G, Hilgers, K, Hofer, H, Hofer, M, Hofer, T, Hoffmann, F, Horisberger, U, Horvath, I, Hsu, Ls, Hu, Gq, Ille, B, Ilyas, Mm, Improta, G, Innocente, V, Isiksal, E, Jagel, E, Jin, Bn, Jones, Lw, Jongmanns, M, Jung, H, Kaaret, P, Kaelin, O, Kaestli, W, Kamyshkov, Y, Kaplan, D, Karpinski, W, Karyotakis, Y, Kertzer, W, Khoze, V, Kirchhoff, G, Kittel, W, Klimentov, A, Klok, Pf, Kollek, M, Koller, M, Konig, Ac, Kornadt, O, Koutsenko, V, Kraemer, Rw, Krastev, Vr, Kratel, A, Krenz, W, Kuhn, A, Kunin, A, Kwan, S, Lacotte, J, Lamarra, M, Landi, G, Lange, W, Lanius, K, Lanske, D, Lanzano, S, Legoff, Jm, Lemarec, Jc, Lea, D, Lebeau, M, Lebrun, P, Lecomte, P, Lecoq, J, Lecoq, P, Lecoultre, P, Leedom, I, Leger, A, Lehmann, F, Leistam, L, Leiste, R, Lejeune, E, Leoni, B, Lettry, J, Leytens, X, Li, C, Li, Ht, Li, L, Li, Pj, Li, Xg, Liao, Jy, Lin, Zy, Linde, Fl, Linnhofer, D, Loftin, E, Lohmann, W, Lokos, S, Longo, E, Lu, Ys, Lubbers, Jm, Lubelsmeyer, K, Luci, Claudio, Luckey, D, Lue, X, Luminari, L, Lunadei, G, Lurken, F, Ma, H, Ma, Wg, Macdermott, M, Madjar, N, Magahiz, R, Maire, M, Malhotra, Pk, Malinin, A, Mana, C, Manna, F, Manto, G, Mao, Yf, Maolinbay, M, Marchesini, P, Marchionni, A, Markwalder, M, Marsden, P, Martin, Jp, Martinez, L, Martyn, Hu, Marzano, F, Marzullo, V, Masciocchi, F, Massaro, Ggg, Massonnet, L, Matsuda, T, Maurelli, G, Mazumdar, K, Mcbride, P, Medici, G, Meier, H, Meinholz, T, Merk, M, Mermod, R, Merola, L, Meschini, M, Metzger, Wj, Micke, M, Micke, U, Mills, Gb, Mnich, J, Moeller, M, Molinero, A, Montanet, L, Monteleoni, B, Montino, R, Morand, G, Morand, R, Morganti, S, Morgunov, V, Mount, R, Moynot, M, Mugnier, P, Nageli, W, Nagy, E, Napolitano, M, Neboux, S, Newman, H, Neyer, C, Nguyen, K, Niessen, L, Nikitin, A, Nowak, Wd, Okle, M, Olmos, P, Onvlee, J, Osborne, D, Ossmann, J, Pandoulas, D, Paprotny, H, Parmentola, A, Passeggio, G, Paternoster, G, Patricelli, S, Pei, Yj, Peng, Y, Perretgallix, D, Perrier, J, Perrin, E, Perrot, G, Petitpas, P, Petschner, P, Pevsner, A, Pieramory, J, Pieri, M, Pieri, V, Pierschel, G, Piroue, Pa, Plyaskin, V, Pohl, M, Pojidaev, V, Pols, Cla, Ponomareff, T, Potyka, J, Produit, N, Prokofiev, P, Pruja, F, Putz, G, Qian, Jm, Raghavan, R, Razis, P, Read, K, Reddick, P, Reissmann, K, Ren, D, Reucroft, S, Rey, D, Reynaud, M, Ricadonna, X, Richeux, Jp, Rippich, C, Rinsche, U, Rocco, R, Rodriguez, S, Roe, Bp, Rohner, M, Rohner, S, Rombach, T, Romero, L, Rose, J, Roser, U, Rosierlees, S, Rubio, Ja, Ruckstuhl, W, Rykaczewski, H, Sahuc, P, Salicio, J, Saran, S, Sauvage, G, Savin, A, Schaad, T, Schafheitle, B, Schegelsky, V, Schetkovsky, A, Schild, F, Schillsott, R, Schmitt, P, Schmitz, D, Schmitz, P, Schneegans, M, Schneider, M, Schneevogt, E, Schontag, M, Schotanus, Dj, Schuijlenburg, H, Schulte, R, Vondratzig, As, Schultze, K, Schwenke, J, Schwering, G, Sciacca, C, Seiler, Pg, Sens, Jc, Sheer, I, Shevchenko, V, Shevchenko, S, Shi, Xr, Shmakov, K, Shoutko, V, Shumilov, E, Siedling, R, Smirnov, N, Souvorov, V, Souyri, C, Spangler, I, Spickermann, T, Spiess, B, Spillantini, P, Starosta, R, Steuer, M, Stickland, Dp, Stohr, B, Stone, H, Strauch, K, Sudhakar, K, Sumner, Rl, Suter, H, Sutton, Rb, Szczesny, H, Tang, J, Tang, Xw, Tarkovsky, E, Tavenrath, A, Tchudakov, V, Thenard, Jm, Thomas, E, Thon, T, Thuerig, H, Thulen, M, Timmermans, C, Ting, Scc, Ting, Sm, Tonisch, F, Tong, Yp, Tonutti, M, Tonwar, Sc, Toth, J, Toth, W, Trowitzsch, G, Tung, Kl, Ulbricht, J, Urban, L, Valente, E, Vandewalle, Rt, Vandergraaf, H, Vanzanella, V, Vergain, M, Vetlitsky, I, Vey, H, Viertel, G, Vivargent, M, Vogel, H, Volkov, S, Vollmar, M, Vongunten, Hp, Vorobiev, I, Vorobyov, A, Vuilleumier, L, Waldmeier, S, Walk, W, Wallraff, W, Wang, Cy, Wang, Gh, Wang, Jh, Wang, Qf, Wang, Xl, Wang, Yf, Wang, Zm, Wassenberg, D, Wegmann, D, Weill, R, Wenaus, Tj, Wenger, P, Wenninger, J, White, M, Wilhelm, R, Willmott, C, Wirth, Hp, Wittgenstein, F, Wu, Rj, Wu, Sx, Wu, Yg, Wyslouch, B, Xi, Fy, Xu, Zz, Xue, Zl, Yan, Ds, Yanev, Kd, Yang, Bz, Yang, Cg, Yang, Ks, Yang, Qy, Yang, Zq, Ye, Ch, Yeh, Sc, Yin, Zw, Zabounidis, C, Zehnder, L, Zeng, Y, Zhang, Dh, Zhang, Sy, Zhang, Zp, Zhou, B, Zhou, Jf, Zhou, Zp, Zhu, Ry, Zichichi, A, Zofka, M, and Zoll, J.

Published
1990

19. Mass limits for scalar muons, scalar electrons, and winos from e+e− collisions near √ = 91 GeV

Author

Adeva, B, Adriani, O, Aguilar-Benítez, M, Akbari, H, Alcaraz, J, Aloisio, A, Alviggi, M G, An, Q, Anderhub, H, Anderson, A L, Antonov, L, Antreasyan, D, Arefev, A, Azemoon, T, Aziz, T, Baba, P V K S, Bagnaia, P, Bakken, J A, Baksay, L, Ball, R C, Banerjee, S, Bao, J, Barone, L, Bay, A, Becker, U, Behrens, J, Beingessner, S, Bencze, G L, Berdugo, J, Berges, P, Bertucci, B, Betev, B L, Biland, A, Bizzarri, R, Blaising, J J, Blömeke, P, Bobbink, Gerjan J, Bocciolini, M, Böhlen, W, Böhm, A, Böhringer, T, Borgia, B, Bourilkov, D, Bourquin, Maurice, Boutigny, D, Branson, J G, Brock, I C, Bruyant, F, Burger, J D, Burq, J P, Cai, X D, Campana, D, Camps, C, Capell, M, Carbonara, F, Carminati, F, Cartacci, A M, Cerrada-Canales, M, Cesaroni, F, Chang, Y H, Chaturvedi, U K, Chemarin, M, Chen, A, Chen, C, Chen, H F, Chen, H S, Chen, M, Chen, M L, Chiefari, G, Chien, C Y, Civinini, C, Clare, I, Clare, R, Coignet, G, Colino, N, Commichau, V, Conforto, G, Contin, A, Crijns, F, Cui, X Y, Dai, T S, D'Alessandro, R, de Bouard, X, Degré, A, Deiters, K, Dénes, E, Denes, P, De Notaristefani, F, Dhina, M, Diemoz, M, Dimitrov, H R, Dionisi, C, Dittus, F B, Dolin, R M, Drago, E, Driever, T, Duinker, P, Durán, I, Engler, A, Eppling, F J, Erné, F C, Extermann, Pierre, Fabbretti, R, Faber, G, Falciano, S, Fan, S J, Fabre, M, Fay, J, Fehlmann, J, Fenker, H C, Ferguson, T, Fernández, G, Ferroni, F, Fesefeldt, H S, Field, J, Forconi, G, Foreman, T, Freudenreich, Klaus, Friebel, W, Fukushima, M, Gailloud, M, Galaktionov, Yu, Gallo, E, Ganguli, S N, Gau, S S, Gavrilov, G E, Gentile, S, Gettner, M, Glaubman, M, Goldfarb, S, Gong, Z F, González, E, Gordeev, A, Göttlicher, P, Goy, C, Gratta, Giorgio, Grimes, A, Grinnell, C, Grünewald, M W, Guanziroli, M, Gurtu, A, Güsewell, D, Haan, H, Hancke, S, Hangarter, K, Harris, M, Harting, D, Hartjes, F G, He, C F, Heavey, A, Hebbeker, T, Hebert, M, Herten, G, Herten, U, Hervé, A, Hilgers, K, Hofer, H, Hsu, L S, Hu, G, Hu, G Q, Ille, B, Ilyas, M M, Innocente, Vincenzo, Isiksal, E, Jagel, E, Jin, B N, Jones, L W, Jongmanns, M, Jung, H, Kaaret, P E, Khan, R A, Kamyshkov, Yu A, Kaplan, D, Karpinski, W, Karyotakis, Yu, Khoze, V, Kirkby, D, Kittel, E W, Klimentov, A, Klok, P F, Kollek, M, Koller, M, König, A C, Kornadt, O, Koutsenko, V F, Krämer, R W, Krastev, V R, Krenz, W, Kuhn, A, Kumar, V, Kunin, A, Kwan, S, Landi, G, Lanius, Karl, Lanske, D, Lanzano, S, Lebeau, M, Lebrun, P, Lecomte, P, Lecoq, P, Le Coultre, P, Leedom, I D, Le Goff, J M, Leistam, L, Leiste, R, Lettry, Jacques, Leytens, X, Li Chuan, Li, H T, Li, J F, Li, L, Li, P J, Li, Q, Li, X G, Liao, J Y, Liu, R, Liu, Y, Lin, Z Y, Linde, Frank L, Lindemann, B, Linnhöfer, D, Lohmann, W, Lökös, S, Longo, E, Lü, Y S, Lubbers, J M, Lübelsmeyer, K, Luci, C, Luckey, D, Ludovici, L, Lue, X, Luminari, L, Ma Wen Gan, MacDermott, M, Magahiz, R, Maire, M, Malhotra, P K, Malinin, A, Maña, C, Mao, D N, Mao, Y F, Maolinbay, M, Marchesini, P A, Marchionni, A, Martin, J P, Martínez, L, Martyn, H U, Marzano, F, Massaro, G G G, Matsuda, T, Mazumdar, K, McBride, P, Meinholz, T, Merk, M, Mermod, R, Merola, L, Meschini, M, Metzger, W J, Mi, Y, Micke, M, Micke, U, Mills, G B, Mir, Y, Mirabelli, G, Mnich, J, Möller, M, Montanet, Lucien, Monteleoni, B, Morand, G, Morand, R, Morganti, S, Morgunov, V, Mount, R, Nagy, E, Napolitano, M, Newman, H, Niessen, L, Nowak, Wolf-Dieter, Onvlee, J, Ossmann, J, Pandoulas, D, Paternoster, G, Patricelli, S, Pei, Y J, Peng, Y, Perret-Gallix, D, Perrier, J, Perrin, E, Pevsner, A, Pieri, M, Pieri, V, Piroué, P A, Plyaskin, V, Pohl, M, Pozhidaev, V, Pols, C L A, Produit, N, Prokofiev, P T, Qian, J M, Qureshi, K N, Raghavan, R, Rahal-Callot, G, Razis, P A, Read, K, Ren, D, Ren, Z, Reucroft, S, Ricker, A, Riemann, Tord, Rippich, C, Rodríguez, S, Roe, B P, Röhner, M, Röhner, S, Romero, L, Rose, J, Rosier-Lees, S, Rosselet, P, Rubio, Juan Antonio, Rückstuhl, W, Rykaczewski, H, Sachwitz, M, Salicio, J, Sassowsky, M, Sauvage, G, Savin, A, Shchegelskii, V, Schetkovsky, A, Schmitt, P, Schmitz, D, Schmitz, P, Schneegans, M, Schöntag, M, Schotanus, D J, Schreiber, H J, Schulte, R, Schultz von Dratzig, A, Schultze, K, Schütte, J, Schwenke, J, Schwering, G, Sciacca, C, Seiler, P G, Sens, Johannes C, Sheer, I, Shevchenko, S, Shevchenko, V, Shi, X R, Shmakov, K D, Shoutko, V, Shumilov, E, Siedling, R, Smirnov, N, Sopczak, André, Souvorov, V, Souyri, C, Spickermann, T, Spiess, B, Spillantini, P, Starosta, R, Steuer, M, Stickland, D P, Stöhr, B, Stone, H, Strauch, K, Sudhakar, K, Sumner, R L, Suter, H, Sutton, R B, Syed, A A, Tang, X W, Tarkovsky, E, Tavenrath, A, Telegdi, Valentine Louis, Thénard, J M, Thomas, E, Timmermans, C, Ting, Samuel C C, Ting, S M, Tong, Y P, Tonutti, M, Tonwar, S C, Tóth, J, Tung, K L, Ulbricht, J, Urbàn, L, Uwer, U, Valente, E, Van de Walle, R T, van der Graaf, H, Vetlitskii, I, Viertel, Gert M, Vikas, P, Vivargent, M, Vogel, H, Vogt, H, Volkov, S, Vorobev, I, Vorobyov, A A, Vuilleumier, L, Walk, W, Wallraff, W, Wang, C Y, Wang, G H, Wang, J H, Wang, Q F, Wang, X L, Wang, Y F, Wang, Z M, Weber, J, Weill, R, Wenaus, T J, Wenninger, J, White, M, Wilhelm, R, Willmott, C, Wittgenstein, F, Wright, D, Wu, R J, Wu Sau Lan, Wu, S X, Wu, Y G, Wyslouch, B, Xu, Z Z, Xue, Z L, Yan, D S, Yang, B Z, Yang, C G, Yang, G, Yang, K S, Yang, Q Y, Yang, Z Q, Ye, Q, Ye, C H, Yeh, S C, Yin, Z W, You, J M, Zabounidis, C R, Zehnder, L, Zeng, M, Zeng, Y, Zhang, D, Zhang, D H, Zhang, S Y, Zhang, Z P, Zhou, J F, Zhu, R Y, Zichichi, Antonino, and Zoll, Julius

Subjects
Physics, Nuclear and High Energy Physics, Particle physics, Muon, Astrophysics::High Energy Astrophysical Phenomena, Electron–positron annihilation, Scalar (physics), Electron, Lower limit, Nuclear physics, Transverse momentum, High Energy Physics::Experiment, Nuclear Experiment, Particle Physics - Experiment
Abstract

We have searched for scalar muons μ , scalar electrons ẽ, and winos W from the reactions e + e − → e + e − , μ + μ − , W + W − at √s ∼ 91 GeV with an integrated luminosity of 157 nb −1 . We have searched for μ + μ − , e + e − , or e− μ final states with missing transverse momentum P T > 6 GeV. These final states are signatures for the production of ẽ, μ , and W. We found no events. Our results are M μ > 41 GeV , M e > 41 GeV , and M W > 44 GeV at the 95% confidence level.

Published
1989
Full Text
View/download PDF

21. [Respiratory and enteric rotavirus infections in a pediatric unit]

Author

András Lakos, Koller M, Szarka E, Csik M, Vandra K, and Pohl O

Subjects
Male, Cross Infection, Hungary, Adolescent, Gastrointestinal Diseases, Child, Preschool, Respiratory Tract Diseases, Humans, Infant, Female, Child, Hospitals, Pediatric, Rotavirus Infections
Published
1985

22. Iatrogenic mechanical ileus due to over-distended uterus

Author

Uzi Dan, Jaron Rabinovici, Koller M, Gad Barkai, and Shlomo Mashiach

Subjects
Adult, medicine.medical_specialty, media_common.quotation_subject, Iatrogenic Disease, Posture, Uterus, Colonic Diseases, Pregnancy, medicine, Humans, Simplicity, media_common, business.industry, General surgery, Obstetrics and Gynecology, respiratory system, Mechanical ileus, medicine.disease, digestive system diseases, Pregnancy Complications, medicine.anatomical_structure, Reproductive Medicine, Female, Pregnancy, Multiple, business, Bed Rest, Intestinal Obstruction
Abstract

The combination of an over-distended uterus caused by a multiple-fetus pregnancy with therapeutic bed-rest may cause mechanical ileus. Iatrogenic triggering of a pathological consequence of events is presented in purpose to highlight the simplicity of its prevention.

Published
1988

27. Evidence Based Postoperative Treatment of Distal Radius Fractures following Internal Locking Plate Fixation

Author

Sm, Klein, Lukas prantl, Koller M, Vykoukal J, Jh, Dolderer, Graf S, Nerlich M, Loibl M, and Geis S

Subjects
Postoperative Care, Fracture Fixation, Internal, Evidence-Based Medicine, Socioeconomic Factors, Humans, Radius Fractures, Wrist Injuries, Bone Plates, Early Ambulation
Abstract

Originally, the treatment method of choice for distal radial fractures (DRF) has been a non-operative approach with six to eight weeks of plaster casting. The introduction of volar locking plate systems at the beginning of the 21 st century has pushed trends towards open reduction and internal fixation (ORIF). While the introduction of fixed angle locking plates together with the increasing knowledge on wrist function and related variable outcomes has led to consensus that operative fixation in instable DRF is the treatment method of choice, there is no agreement on a postoperative care of these injuries. The authors will discuss the available evidence for current concepts of postoperative treatment of DRFs following fixed angle fixation under socioeconomical, biomechanical and burden of disease aspects. Further, relevant randomized controlled trials are evaluated with regard to applied postoperative treatment regimes and related risks for complications.

29. Risk charts to guide targeted HIV-1 viral load monitoring of art: Development and validation in patients from resource-limited settings

Author

Koller, M., Geoffrey Fatti, Chi, B. H., Keiser, O., Hoffmann, C. J., Wood, R., Prozesky, H., Stinson, K., Giddy, J., Mutevedzi, P., Fox, M. P., Law, M., Boulle, A., and Egger, M.

Subjects
360 Social problems & social services, 610 Medicine & health
Abstract

BACKGROUND HIV-1 RNA viral load (VL) testing is recommended to monitor antiretroviral therapy (ART) but not available in many resource-limited settings. We developed and validated CD4-based risk charts to guide targeted VL testing. METHODS We modeled the probability of virologic failure up to 5 years of ART based on current and baseline CD4 counts, developed decision rules for targeted VL testing of 10%, 20% or 40% of patients in seven cohorts of patients starting ART in South Africa, and plotted cut-offs for VL testing on colour-coded risk charts. We assessed the accuracy of risk chart-guided VL testing to detect virologic failure in validation cohorts from South Africa, Zambia and the Asia-Pacific. FINDINGS 31,450 adult patients were included in the derivation and 25,294 patients in the validation cohorts. Positive predictive values increased with the percentage of patients tested: from 79% (10% tested) to 98% (40% tested) in the South African, from 64% to 93% in the Zambian and from 73% to 96% in the Asia-Pacific cohorts. Corresponding increases in sensitivity were from 35% to 68% in South Africa, from 55% to 82% in Zambia and from 37% to 71% in Asia-Pacific. The area under the receiver-operating curve increased from 0.75 to 0.91 in South Africa, from 0.76 to 0.91 in Zambia and from 0.77 to 0.92 in Asia Pacific. INTERPRETATION CD4-based risk charts with optimal cut-offs for targeted VL testing may be useful to monitor ART in settings where VL capacity is limited.

Full Text
View/download PDF

30. A MEASUREMENT OF THE Z0 LEPTONIC PARTIAL WIDTHS AND THE FORWARD - BACKWARD ASYMMETRY

Author

Adeva, B., Adriani, O., Aguilar-Benitez, M., Akbari, H., Alcaraz, J., Aloisio, A., Alverson, G., Alviggi, M. G., An, Q., Anderhub, H., Andersson, A. L., Antonov, L., Antreasyan, D., Arefev, A., Auroy, B., Azemoon, T., Aziz, T., Bagnaia, P., Bakken, J. A., Baksay, L., Ball, R. C., Banerjee, S., Bao, J., Barone, L., Bay, A., Becker, U., Beingessner, S., Bencze, G. L., Bencze, G., Berdugo, J., Berges, P., Bertucci, B., Betev, B. L., Biland, A., Bizzarri, R., Blaising, J. J., Blomeke, P., Blumenfeld, Barry J., Bobbink, G. J., Bocciolini, M., Bohlen, W., Bohm, A., Bohringer, T., Borgia, B., Bourilkov, D., Bourquin, M., Boutigny, D., Branson, J. G., Brock, I. C., Bruyant, F., Burger, J. D., Burq, J. P., Cai, X., Campana, D., Camps, C., Capell, M., Carbonara, F., Carminati, F., Cartacci, A. M., Cerrada, M., Cesaroni, F., Chang, Y. H., Chaturvedi, U. K., Chemarin, M., Chen, A., Chen, C., Chen, G. M., Chen, H. F., Chen, H. S., Chen, M., Chen, M. L., Chiefari, G., Chien, C. Y., Civinini, C., Clare, I., Clare, R., Coignet, G., Colino, N., Commichau, V., Conforto, G., Crijns, F., Cui, X. Y., Dai, T. S., D Alessandro, R., Bouard, X., Degre, A., Deiters, K., Denes, Ervin, Denes, P., Denotaristefani, F., Dhina, M., Diemoz, M., Dimitrov, H. R., Dionisi, C., Dittus, F., Dolin, R., Drago, E., Driever, T., Duinker, P., Duran, I., Engler, A., Eppling, F. J., Erne, F. C., Extermann, P., Fabbretti, R., Faber, G., Falciano, S., Fan, S. J., Fabre, M., Fay, J., Fehlmann, J., Fenker, Howard C., Ferguson, T., Fernandez, G., Ferroni, F., Fesefeldt, H., Field, J., Forconi, G., Foreman, T., Freudenreich, K., Friebel, W., Fukushima, M., Gailloud, M., Galaktionov, Iouri, Gallo, E., Ganguli, S. N., Gau, S. S., Gavrilov, G., Gentile, S., Gettner, M., Glaubman, M., Goldfarb, S., Gong, Z. F., Gonzalez, E., Gordeev, A., Gottlicher, P., Goy, C., Gratta, G., Grimes, A., Grinnell, C., Grunewald, M., Guanziroli, M., Gurtu, A., Gusewell, D., Haan, H., Hangarter, K., Hancke, S., Harris, M., Harting, D., Hartjes, F. G., He, C. F., Heavey, A., Hebbeker, T., Hebert, M., Herten, G., Herten, U., Herve, Alain, Hilgers, K., Hofer, H., Hsu, L. S., Hu, G., Hu, G. Q., Ille, B., Ilyas, M. M., Innocente, V., Isiksal, E., Jagel, E., Jin, B. N., Jones, Lawrence W., Jongmanns, M., Jung, H., Kaaret, P., Khan, R. A., Kamyshkov, Yuri A., Kaplan, D., Karpinski, W., Karyotakis, Y., Khoze, Valery A., Kirkby, David P., Kittel, W., Klimentov, A., Klok, P. F., Kollek, M., Koller, M., Konig, A. C., Kornadt, O., Koutsenko, V., Kraemer, R. W., Krastev, V. R., Krenz, W., Kuhn, A., Kunin, A., Kwan, S., Landi, G., Lanius, K., Lanske, D., Lanzano, S., Le Goff, J. M., Lebrun, P., Lecomte, P., Lecoq, P., Le Coultre, P., Leedom, I., Leistam, L., Leiste, R., Lettry, J., Leytens, X., Li, C., Li, H. T., Li, J. F., Li, L., Li, P. J., Li, X. G., Liao, J. Y., Liu, R., Liu, Y., Lin, Z. Y., Linde, F. L., Lindemann, B., Linnhofer, D., Lohmann, W., Lokos, S., Longo, E., Lu, Y. S., Lubbers, J. M., Lubelsmeyer, K., Luci, C., Luckey, David, Ludovici, L., Lue, X., Luminari, L., Ma, W. G., Macdermott, M., Magahiz, R., Maire, M., Malhotra, P. K., Malinin, A., Mana, C., Mao, D. N., Mao, Y. F., Maolinbay, M., Marchesini, P., Marchionni, A., Martin, J. P., Martinez, L., Martyn, H. U., Marzano, F., Massaro, G. G. G., Matsuda, T., Mazumdar, K., Mcbride, P., Meinholz, T., Merk, M., Mermod, R., Merola, L., Meschini, M., Metzger, W. J., Mi, Y., Micke, M., Micke, U., Mills, Geoffrey B., Mir, Y., Mirabelli, G., Mnich, J., Moller, M., Montanet, L., Monteleoni, B., Morand, G., Morand, R., Morganti, Silvio, Morgunov, V., Mount, R., Nagy, E., Napolitano, M., Newman, H., Niessen, L., Nowak, W. D., Onvlee, J., Ossmann, J., Pandoulas, D., Paternoster, G., Patricelli, S., Pei, Y. J., Peng, Y., Perret-Gallix, D., Perrier, J., Perrin, E., Pevsner, A., Pieri, M., Pieri, V., Piroue, P. A., Plyaskin, V., Pohl, M., Pozhidaev, V., Pols, C. L. A., Produit, N., Prokofev, P., Qian, J. M., Raghavan, R., Razis, P., Kenneth Read, Ren, D., Ren, Z., Reucroft, S., Ricker, A., Riemann, T., Rippich, C., Rodriguez, S., Roe, B. P., Rahal-Callot, G., Rohner, M., Rohner, S., Romero, L., Rose, J., Rosier-Lees, S., Rosselet, P., Rubio, J. A., Ruckstuhl, W., Rykaczewski, H., Sachwitz, M., Salicio, J., Sassowsky, M., Sauvage, G., Savin, A., Shchegelsky, V., Shchetkovsky, A., Schmitt, P., Schmitz, D., Schmitz, P., Schneegans, M., Schontag, M., Schotanus, D. J., Schreiber, H. J., Schulte, R., Schultz Dratzig, A., Schultze, K., Schutte, J., Schwenke, J., Schwering, G., Sciacca, C., Seiler, P. G., Sens, J. C., Sheer, I., Shevchenko, V., Shevchenko, S., Shi, X. R., Shmakov, K., Shoutko, V., Shumilov, E., Siedling, R., Smirnov, N., Sopczak, A., Souvorov, V., Souyri, C., Spickermann, T., Spiess, B., Spillantini, P., Starosta, R., Steuer, M., Stickland, D. P., Stohr, B., Stone, H., Strauch, K., Sudhakar, K., Sumner, Richard L., Suter, H., Sutton, R. B., Syed, A. A., Tang, X. W., Tarkovsky, E. I., Tavenrath, A., Thenard, J. M., Thomas, E., Timmermans, Charles, Ting, Samuel C. C., Ting, S. M., Tong, Y. P., Tonutti, M., Tonwar, S. C., Toth, J., Tung, K. L., Ulbricht, J., Urban, L., Uwer, U., Valente, E., Walle, R. T., Graaf, H., Vetlitsky, I., Viertel, G., Vikas, P., Vivargent, M., Vogel, H., Vogt, H., Volkov, S., Vorobev, I., Vorobev, A., Vuilleumier, L., Walk, W., Wallraff, W., Wang, C. Y., Wang, G. H., Wang, J. H., Wang, Q. F., Wang, X. L., Wang, Y. F., Wang, Z. M., Weber, J., Weill, R., Wenaus, T. J., Wenninger, J., White, M., Wilhelm, R., Willmott, C., Wittgenstein, F., Wright, D., Wu, R. J., Wu, S. L., Wu, S. X., Wu, Y. G., Wyslouch, B., Xu, Z. Z., Xue, Z. L., Yan, D. S., Yang, B. Z., Yang, C. G., Yang, K. S., Yang, Q. Y., Yang, Z. Q., Ye, Q., Ye, C. H., Yeh, S. C., Yin, Z. W., You, Z. M., Zabounidis, C., Zehnder, L., Zeng, M., Zeng, Y., Zhang, D., Zhang, D. H., Zhang, S. Y., Zhang, Z. P., Zhou, J. F., Zhu, R. Y., Zichichi, A., and Zoll, J.

36. Treatment and prognosis of AIDS-related lymphoma in the era of highly active antiretroviral therapy: Findings from the Swiss HIV Cohort Study

Author

Simcock, M., Blasko, M., Karrer, U., Bertisch, B., Pless, M., Blumer, L., Vora, S., Robinson, J. O., Bernasconi, E., Terziroli, B., Moirandat-Rytz, S., Furrer, H., Hirschel, B., Vernazza, P., Sendi, P., Rickenbach, M., Bucher, H. C., Battegay, M., Koller, M. T., Böni, J., Bucher, H., Bürgisser, Ph, Cattacin, S., Cavassini, M., Dubs, R., Matthias Egger, Elzi, L., Erb, P., Fischer, M., Flepp, M., Fontana, A., Francioli, P., Gorgievski, M., Günthard, H., Hirsch, H., Hösli, I., Kahlert, Ch, Kaiser, L., Kind, C., Klimkait, Th, Ledergerber, B., Martinetti, G., Martinez, B., Müller, N., Nadal, D., Opravil, M., Paccaud, F., Pantaleo, G., Rudin, C., Schmid, P., Schultze, D., Schüpbach, J., Speck, R., Taffé, P., Tarr, P., Telenti, A., Trkola, A., Weber, R., and Yerly, S.

37. Donation type and the effect of pre-transplant donor specific antibodies – Data from the Swiss Transplant Cohort Study

Author

de Rougemont, Olivier, Deng, Yun, Frischknecht, Lukas, Wehmeier, Caroline, Villard, Jean, Ferrari-Lacraz, Sylvie, Golshayan, Déla, Gannagé, Monique, Binet, Isabelle, Wirthmüller, Urs, Sidler, Daniel, Schachtner, Thomas, Schaub, Stefan, Nilsson, Jakob, Swiss Transplant Cohort Study, Amico, P., Axel, A., Aubert, J.D., Banz, V., Sonja, B., Beldi, G., Berger, C., Berishvili, E., Binet, I., Bochud, P.Y., Branca, S., Bucher, H., Carrel, T., Catana, E., Chalandon, Y., De Geest, S., De Rougemont, O., Dickenmann, M., Dreifuss, J.L., Duchosal, M., Fehr, T., Ferrari-Lacraz, S., Franscini, N., Garzoni, C., Soccal, P.G., Gaudet, C., Golshayan, D., Goossens, N., Hadaya, K., Halter, J., Heim, D., Hess, C., Hillinger, S., Hirsch, H., Hirt, P., Hofbauer, G., Huynh-Do, U., Immer, F., Koller, M., Laager, M., Laesser, B., Lehmann, R., Leichtle, A., Lovis, C., Manuel, O., Marti, H.P., Martin, P.Y., Martinelli, M., McLin, V., Mellac, K., Mercay, A., Mettler, K., Mueller, N., Müller, A., Müller, T., Müller-Arndt, U., Müllhaupt, B., Nägeli, M., Oldani, G., Pascual, M., Posfay-Barbe, K., Rick, J., Rosselet, A., Rossi, S., Rothlin, S., Ruschitzka, F., Schanz, U., Schaub, S., Schnyder, A., Schuurmans, M., Sengstag, T., Simonetta, F., Staufer, K., Stampf, S., Steiger, J., Stirniman, G., Stürzinger, U., Van Delden, C., Venetz, J.P., Villard, J., Vionnet, J., Wick, M., Wilhlem, M., and Yerly, P.

Subjects
Humans, Antibodies, Blood Grouping and Crossmatching, Cohort Studies, Living Donors, Switzerland, ABMR, DBD, DCD, donor specific antibodies, graft loss, kidney transplantation, living donation, virtual cross-match, Immunology, Immunology and Allergy, 610 Medicine & health, 610 Medizin und Gesundheit
Abstract

IntroductionThe type of donation may affect how susceptible a donor kidney is to injury from pre-existing alloimmunity. Many centers are, therefore, reluctant to perform donor specific antibody (DSA) positive transplantations in the setting of donation after circulatory death (DCD). There are, however, no large studies comparing the impact of pre-transplant DSA stratified on donation type in a cohort with a complete virtual cross-match and long-term follow-up of transplant outcome.MethodsWe investigated the effect of pre-transplant DSA on the risk of rejection, graft loss, and the rate of eGFR decline in 1282 donation after brain death (DBD) transplants and compared it to 130 (DCD) and 803 living donor (LD) transplants.ResultsThere was a significant worse outcome associated with pre-transplant DSA in all of the studied donation types. DSA directed against Class II HLA antigens as well as a high cumulative mean fluorescent intensity (MFI) of the detected DSA showed the strongest association with worse transplant outcome. We could not detect a significant additive negative effect of DSA in DCD transplantations in our cohort. Conversely, DSA positive DCD transplants appeared to have a slightly better outcome, possibly in part due to the lower mean fluorescent intensity (MFI) of the pre-transplant DSA. Indeed when DCD transplants were compared to DBD transplants with similar MFI (DiscussionOur results suggest that the negative impact of pre-transplant DSA on graft outcome could be similar between all donation types. This suggests that immunological risk assessment could be performed in a similar way regardless of the type of donor kidney transplantation.

Published
2023
Full Text
View/download PDF

38. Surgical site infections after simultaneous pancreas kidney and pancreas transplantation in the Swiss Transplant Cohort Study

Author

P.W. Schreiber, M. Laager, K. Boggian, D. Neofytos, C. van Delden, A. Egli, M. Dickenmann, C. Hirzel, O. Manuel, M. Koller, S. Rossi, B. Schmied, L. Gürke, M. Matter, T. Berney, O. de Rougemont, S.P. Kuster, S. Stampf, N.J. Mueller, P. Amico, J-D. Aubert, V. Banz, S. Beckmann, G. Beldi, C. Berger, E. Berishvili, A. Berzigotti, I. Binet, P-Y. Bochud, S. Branca, H. Bucher, E. Catana, A. Cairoli, Y. Chalandon, S. De Geest, O. De Rougemont, S. De Seigneux, J.L. Dreifuss, M. Duchosal, T. Fehr, S. Ferrari-Lacraz, C. Garzoni, D. Golshayan, N. Goossens, F.H.J. Halter, D. Heim, C. Hess, S. Hillinger, H.H. Hirsch, P. Hirt, G. Hofbauer, U. Huynh-Do, F. Immer, B. Laesser, F. Lamoth, R. Lehmann, A. Leichtle, H.P. Marti, M. Martinelli, V. McLin, K. Mellac, A. Merçay, K. Mettler, A. Müller, U. Müller-Arndt, B. Müllhaupt, M. Nägeli, G. Oldani, M. Pascual, J. Passweg, R. Pazeller, K. Posfay-Barbe, J. Rick, A. Rosselet, S. Rothlin, F. Ruschitzka, T. Schachtner, U. Schanz, S. Schaub, A. Scherrer, A. Schnyder, M. Schuurmans, S. Schwab, T. Sengstag, F. Simonetta, J. Steiger, G. Stirnimann, U. Stürzinger, C. Van Delden, J-P. Venetz, J. Villard, J. Vionnet, M. Wick, M. Wilhelm, P. Yerly, Swiss Transplant Cohort Study, Amico, P., Aubert, J.D., Banz, V., Beckmann, S., Beldi, G., Berger, C., Berishvili, E., Berzigotti, A., Binet, I., Bochud, P.Y., Branca, S., Bucher, H., Catana, E., Cairoli, A., Chalandon, Y., De Geest, S., De Rougemont, O., De Seigneux, S., Dickenmann, M., Dreifuss, J.L., Duchosal, M., Fehr, T., Ferrari-Lacraz, S., Garzoni, C., Golshayan, D., Goossens, N., Halter, FHJ, Heim, D., Hess, C., Hillinger, S., Hirsch, H.H., Hirt, P., Hofbauer, G., Huynh-Do, U., Immer, F., Koller, M., Laager, M., Laesser, B., Lamoth, F., Lehmann, R., Leichtle, A., Manuel, O., Marti, H.P., Martinelli, M., McLin, V., Mellac, K., Merçay, A., Mettler, K., Müller, A., Mueller, N.J., Müller-Arndt, U., Müllhaupt, B., Nägeli, M., Oldani, G., Pascual, M., Passweg, J., Pazeller, R., Posfay-Barbe, K., Rick, J., Rosselet, A., Rossi, S., Rothlin, S., Ruschitzka, F., Schachtner, T., Schanz, U., Schaub, S., Scherrer, A., Schnyder, A., Schuurmans, M., Schwab, S., Sengstag, T., Simonetta, F., Stampf, S., Steiger, J., Stirnimann, G., Stürzinger, U., Van Delden, C., Venetz, J.P., Villard, J., Vionnet, J., Wick, M., Wilhelm, M., and Yerly, P.

Subjects
Microbiology (medical), Adult, 610 Medicine & health, General Medicine, Kidney, Cohort Studies, Humans, Kidney Transplantation/adverse effects, Pancreas, Pancreas Transplantation/adverse effects, Risk Factors, Surgical Wound Infection/epidemiology, Surgical Wound Infection/etiology, Switzerland/epidemiology, Hospital-acquired infection, Pancreas transplantation, Simultaneous kidney–pancreas transplantation, Surgical site infection, Kidney Transplantation, Infectious Diseases, Surgical Wound Infection, Pancreas Transplantation, Switzerland
Abstract

BACKGROUND Among hospital-acquired infections, surgical site infections (SSIs) are frequent. SSI in the early post-transplant course poses a relevant threat to transplant recipients. AIM To determine incidence, risk factors for SSI and its association with post-transplant outcomes and pancreas transplant (P-Tx) recipients. METHODS Adult simultaneous kidney-pancreas transplantation (SPK-T) and P-Tx recipients with a follow-up of at least 90 days were identified in the Swiss Transplant Cohort Study (STCS) dataset. Except for the categorization of SSIs according to Centers for Disease Control and Prevention (CDC) criteria, all other data were prospectively collected. Risk factors for SSI were investigated with logistic regression. A Weibull accelerated failure-time model was applied to address the impact of SSI on length of stay, correcting for transplant-related complications and delayed graft function. FINDINGS Of 130 transplant recipients, 108 SPK-Tx and 22 P-Tx, 18 (14%) individuals developed SSI within the first 90 days after transplantation. Deep incisional (seven, 38.9%) and organ/space infections (eight, 44.4%) predominated. In the majority of SSIs (11, 61.1%; two SSIs with simultaneous identification of fungal pathogens) bacteria were detected with Enterococcus spp. being most frequent. The median duration of hospitalization after transplantation was significantly longer in recipients with SSI (median: 26 days; interquartile range (IQR): 19-44) than in patients without SSI (median: 17 days; IQR: 12-25; P = 0.002). In multivariate analysis, SSI was significantly associated with increased length of stay and prolonged the duration of hospitalization by 36% (95% confidence interval: 4-79). CONCLUSION SSI after SPK-Tx and P-Tx occurred at a frequency of 14%. Among pathogens, Enterococcus spp. predominated. SSI was independently associated with a longer hospitalization after transplantation.

Published
2022
Full Text
View/download PDF

39. Temporal trends, risk factors and outcomes of infections due to extended-spectrum β-lactamase producing Enterobacterales in Swiss solid organ transplant recipients between 2012 and 2018

Author

Kohler, Philipp, Wolfensberger, Aline, Stampf, Susanne, Brönnimann, Andreas, Boggian, Katia, van Delden, Christian, Favre, Melody, Hirzel, Cédric, Khanna, Nina, Kuster, Stefan P, Manuel, Oriol, Neofytos, Dionysios, Ragozzino, Silvio, Schreiber, Peter W, Walti, Laura, Mueller, Nicolas J, Swiss Transplant Cohort Study, Chalandon, Yves, Gasche-Soccal, Paola Marina Alessandra, Gaudet-Blavignac, Christophe, Lovis, Christian, Martin, Pierre-Yves, Posfay Barbe, Klara, Simonetta, Federico, Toso, Christian, Villard, Jean, Swiss Transplant Cohort Study, Amico, P., Axel, A., Aubert, J.D., Banz, V., Sonja, B., Beldi, G., Benden, C., Berger, C., Binet, I., Bochud, P.Y., Branca, S., Bucher, H., Carrel, T., Catana, E., Chalandon, Y., de Geest, S., de Rougemont, O., Dickenmann, M., Dreifuss, J.L., Duchosal, M., Fehr, T., Ferrari-Lacraz, S., Garzoni, C., Soccal, P.G., Gaudet, C., Giostra, E., Golshayan, D., Hadaya, K., Halter, J., Hauri, D., Heim, D., Hess, C., Hillinger, S., Hirsch, H., Hirt, P., Hofbauer, G., Huynh-Do, U., Immer, F., Koller, M., Laesser, B., Lang, B., Lehmann, R., Leichtle, A., Lovis, C., Manuel, O., Marti, H.P., Martin, P.Y., Martinelli, M., Mellac, K., Merçay, A., Mettler, K., Meylan, P., Mueller, N., Müller, A., Müller, T., Müller-Arndt, U., Müllhaupt, B., Nägeli, M., Pascual, M., Posfay-Barbe, K., Rick, J., Rosselet, A., Rossi, S., Rothlin, S., Ruschitzka, F., Schanz, U., Schaub, S., Schnyder, A., Schuurmans, M., Simonetta, F., Staufer, K., Stampf, S., Steiger, J., Stirniman, G., Toso, C., Van Delden, C., Venetz, J.P., Villard, J., Wick, M., Wilhelm, M., Yerly, P., University of Zurich, and Kohler, Philipp

Subjects
Graft Rejection, Male, 0301 basic medicine, 10255 Clinic for Thoracic Surgery, Antibiotics, Drug resistance, 030230 surgery, 2726 Microbiology (medical), Organ transplantation, 10234 Clinic for Infectious Diseases, Enterobacterales, 0302 clinical medicine, Medical microbiology, Risk Factors, 2736 Pharmacology (medical), Medicine, Pharmacology (medical), Prospective Studies, Prospective cohort study, 610 Medicine & health, Escherichia coli Infections, ddc:616, Enterobacteriaceae Infections, Middle Aged, Anti-Bacterial Agents, Extended-spectrum beta-lactamase, Renal transplant, Infectious Diseases, 10209 Clinic for Cardiology, Female, Switzerland, Cohort study, Adult, Microbiology (medical), medicine.medical_specialty, medicine.drug_class, 030106 microbiology, beta-Lactamases, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Enterobacteriaceae, Internal medicine, Drug Resistance, Bacterial, Humans, lcsh:RC109-216, Risk factor, Aged, business.industry, Research, Public Health, Environmental and Occupational Health, Organ Transplantation, 2739 Public Health, Environmental and Occupational Health, 2725 Infectious Diseases, Transplant Recipients, Solid organ transplant, Transplantation, Case-Control Studies, 10032 Clinic for Oncology and Hematology, bacteria, business
Abstract

Background The burden of antimicrobial resistance is high in solid organ transplant (SOT) recipients. Among Swiss SOT recipients, we assessed temporal trends of ESBL-producing Enterobacterales (ESBL-E), identified risk factors for ESBL-E, and assessed the impact of resistance on patient outcome. Methods Data from the Swiss Transplant Cohort Study (STCS), a nationwide prospective cohort of SOT-recipients, were analysed. Temporal trends were described for ESBL-detection among Escherichia coli and non-Escherichia coli. In a nested case–control study, cases with ESBL-E infection were 1:1 matched (by time since transplantation, organ transplant, pathogen) to controls infected with non-ESBL-E. Factors associated with resistance and with unfavourable 30-day outcome (death, infection relapse, graft loss) were assessed. Results From 2012 to 2018, we identified 1′212 infection episodes caused by Enterobacterales in 1′074 patients, thereof 11.4% (138/1′212) caused by ESBL-E. The proportion of ESBL-production among Escherichia coli remained stable over time (p = 0.93) but increased for non-E. coli (p = 0.02) Enterobacterales. In the case–control study (n = 102), antibiotic pre-treatment was independently associated with ESBL-production (aOR = 2.6, 95%-CI: 1.0–6.8, p = 0.046). Unfavourable outcome occurred in 24/51 (47%) cases and 9/51 (18%) controls (p = 0.003). Appropriate empiric antibiotic therapy was the only modifiable factor associated with unfavourable outcome. Conclusions In Swiss SOT-recipients, proportion of infections with ESBL-producing non-E. coli Enterobacterales increased in recent years. Antibiotic pre-treatment represents a risk factor for ESBL-E. Improving appropriateness of empiric antibiotic treatment might be an important measure to reduce unfavourable outcome, which was observed in almost half of SOT-recipients with ESBL-E infections.

Published
2021
Full Text
View/download PDF

40. Pneumocystis jirovecii pneumonia in solid organ transplant recipients: a descriptive analysis for the Swiss Transplant Cohort

Author

Neofytos, Dionysios, Hirzel, Cédric, Boely, Elsa, Lecompte, Thanh, Khanna, Nina, Mueller, Nicolas J, Boggian, Katia, Cusini, Alexia, Manuel, Oriol, Banz Wüthrich, Vanessa, Beldi, Guido, Stirnimann, Guido, van Delden, Christian, Swiss Transplant, Cohort Study, Swiss Transplant Cohort Study, Amico, P., Aubert, J.D., Banz, V., Beldi, G., Benden, C., Berger, C., Binet, I., Bochud, P.Y., Boëly, E., Bucher, H., Carell, T., Catana, E., Chalandon, Y., de Geest, S., de Rougemont, O., Dickenmann, M., Duchosal, M., Elkrief, L., Fehr, T., Ferrari-Lacraz, S., Garzoni, C., Soccal, P.G., Gaudet, C., Giostra, E., Golshayan, D., Hadaya, K., Halter, J., Heim, D., Hess, C., Hillinger, S., Hirsch, H.H., Hofbauer, G., Huynh-Do, U., Immer, F., Klaghofer, R., Koller, M., Laesser, B., Lehmann, R., Lovis, C., Majno, P., Marti, H.P., Martin, P.Y., Meylan, P., Mohacsi, P., Morel, P., Mueller, U., Mueller-McKenna, H., Müller, A., Müller, T., Müllhaupt, B., Pascual, M., Passweg, J., Posfay-Barbe, K., Rick, J., Roosnek, E., Rosselet, A., Rothlin, S., Ruschitzka, F., Schanz, U., Schaub, S., Schnyder, A., Seiler, C., Sprachta, J., Stampf, S., Steiger, J., Stirnimann, G., Toso, C., Venetz, J.P., Villard, J., Wick, M., Wilhelm, M., Yerly, P., University of Zurich, and Neofytos, Dionysios

Subjects
0301 basic medicine, Male, Epidemiology, 2747 Transplantation, Pneumocystis carinii, Adult, Aged, Anti-Bacterial Agents/therapeutic use, Antibiotic Prophylaxis/methods, Antibiotic Prophylaxis/standards, Female, Humans, Incidence, Middle Aged, Mortality, Organ Transplantation/adverse effects, Pneumocystis carinii/isolation & purification, Pneumonia, Pneumocystis/drug therapy, Pneumonia, Pneumocystis/epidemiology, Pneumonia, Pneumocystis/microbiology, Pneumonia, Pneumocystis/prevention & control, Practice Guidelines as Topic, Prospective Studies, Switzerland/epidemiology, Treatment Outcome, Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use, Young Adult, Pneumocystis jirovecii pneumonia, Solid organ transplant recipients, 10234 Clinic for Infectious Diseases, 0302 clinical medicine, 030212 general & internal medicine, Prospective cohort study, 610 Medicine & health, education.field_of_study, ddc:617, Incidence (epidemiology), Pneumonia, Pneumocystis, Anti-Bacterial Agents, Infectious Diseases, 10219 Clinic for Gastroenterology and Hepatology, Cohort, 10209 Clinic for Cardiology, 10178 Clinic for Pneumology, Switzerland, medicine.drug, medicine.medical_specialty, 030106 microbiology, Population, 03 medical and health sciences, Internal medicine, parasitic diseases, Trimethoprim, Sulfamethoxazole Drug Combination, medicine, education, Transplantation, business.industry, 2725 Infectious Diseases, Organ Transplantation, Antibiotic Prophylaxis, medicine.disease, Trimethoprim, Pneumonia, Complication, business
Abstract

BACKGROUND Descriptive data on Pneumocystis jirovecii pneumonia (PJP) in solid organ transplant recipients (SOTr) in the era of routine Pneumocystis-prophylaxis are lacking. METHODS All adult SOTr between 2008-2016 were included. PJP was diagnosed based on consensus guidelines. Early-onset PJP was defined as PJP within the 1st-year-post-transplant. RESULTS 41/2842 SOTr (1.4%) developed PJP (incidence rate: 0.01/1000 person-days) at a mean of 493-days post-transplant: 21 (51.2%) early vs 20 (48.8%) late-onset PJP. 2465 (86.7%) SOTr received Pneumocystis-prophylaxis for a mean 316 days. PJP incidence was 0.001% and 0.003% (log-rank

Published
2018
Full Text
View/download PDF

41. CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation

Author

Zoltán Kutalik, Pierre-Yves Bochud, Séverine Crettol, Nicolas J. Mueller, Roger Lehmann, Manuel Pascual, Jean-François Dufour, Paola M. Soccal, Isabelle Binet, Andrea Treyer, Jürg Steiger, Dela Golshayan, Lina Quteineh, Chin B. Eap, Jean-Pierre Venetz, C. van Delden, Paul Mohacsi, Oriol Manuel, and The Swiss Transplant Cohort Study, Achermann, R., Aubert, J.D., Baumann, P., Beldi, G., Benden, C., Berger, C., Binet, I., Bochud, P.Y., Boely, E., Bucher, H., Bühler, L., Carell, T., Catana, E., Chalandon, Y., Geest, S., Rougemont, O., Dickenmann, M., Duchosal, M., Fehr, T., Ferrari-Lacraz, S., Garzoni, C., Gasche, Y., Soccal, P.G., Giostra, E., Golshayan, D., Good, D., Hadaya, K., Hess, C., Hillinger, S., Hirsch, H., Hofbauer, G., Huynh-Do, U., Immer, F., Klaghofer, R., Koller, M., Kuntzen, T., Laesser, B., Lehmann, R., Lovis, C., Manuel, O., Marti, H.P., Martin, P.Y., Meylan, P., Mohacsi, P., Morard, I., Morel, P., Mueller, U., Mueller, N., Mueller-McKenna, H., Müller, T., Müllhaupt, B., Nadal, D., Nair, G., Pascual, M., Passweg, J., Ziegler, C.P., Rick, J., Roosnek, E., Rosselet, A., Rothlin, S., Ruschitzka, F., Schanz, U., Schaub, S., Seiler, C., Semmo, N., Stampf, S., Steiger, J., Toso, C., Tsinalis, D., Delden, C.V., Venetz, J.P., Villard, J., Wick, M., Wilhelm, M., Yerly, P., University of Zurich, and Eap, C B

Subjects
0301 basic medicine, Time Factors, Physiology, Pharmacology, Organ transplantation, 10234 Clinic for Infectious Diseases, Diabetes mellitus genetics, Gene Frequency, Risk Factors, Odds Ratio, Prevalence, ddc:616, Metabolic Syndrome, 2. Zero hunger, education.field_of_study, Incidence, Homozygote, 3. Good health, 10219 Clinic for Gastroenterology and Hepatology, 3004 Pharmacology, Phenotype, Treatment Outcome, 10209 Clinic for Cardiology, Molecular Medicine, 10178 Clinic for Pneumology, Switzerland, Heterozygote, medicine.medical_specialty, Population, 610 Medicine & health, Biology, Polymorphism, Single Nucleotide, Risk Assessment, 03 medical and health sciences, Insulin resistance, 1311 Genetics, Diabetes mellitus, Diabetes Mellitus, Genetics, medicine, Humans, Diabetes Mellitus/epidemiology, Diabetes Mellitus/genetics, Dyslipidemias/epidemiology, Dyslipidemias/genetics, Genetic Predisposition to Disease, Linear Models, Logistic Models, Metabolic Syndrome X/diagnosis, Metabolic Syndrome X/epidemiology, Metabolic Syndrome X/genetics, Multivariate Analysis, Obesity/epidemiology, Obesity/genetics, Organ Transplantation/adverse effects, Switzerland/epidemiology, Transcription Factors/genetics, Obesity, education, Dyslipidemias, Organ Transplantation, Odds ratio, medicine.disease, 10020 Clinic for Cardiac Surgery, Transplantation, 030104 developmental biology, 1313 Molecular Medicine, Metabolic syndrome, Transcription Factors
Abstract

Metabolic syndrome after transplantation is a major concern following solid organ transplantation (SOT). The CREB-regulated transcription co-activator 2 (CRTC2) regulates glucose metabolism. The effect of CRTC2 polymorphisms on new-onset diabetes after transplantation (NODAT) was investigated in a discovery sample of SOT recipients (n1=197). Positive results were tested for replication in two samples from the Swiss Transplant Cohort Study (STCS, n2=1294 and n3=759). Obesity and other metabolic traits were also tested. Associations with metabolic traits in population-based samples (n4=46'186, n5=123'865, n6>100,000) were finally analyzed. In the discovery sample, CRTC2 rs8450-AA genotype was associated with NODAT, fasting blood glucose and body mass index (PcorrectedA was significantly associated with several metabolic abnormalities. CRTC2 rs8450G>A appears to have an important role in the high prevalence of metabolic traits observed in patients with SOT. A weak association with metabolic traits was also observed in the population-based samples.The Pharmacogenomics Journal advance online publication, 8 December 2015; doi:10.1038/tpj.2015.82.

Published
2015
Full Text
View/download PDF

42. PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant

Author

Wójtowicz, A., Lecompte, T.D., Bibert, S., Manuel, O., Rüeger, S., Berger, C., Boggian, K., Cusini, A., Garzoni, C., Hirsch, H., Khanna, N., Mueller, N.J., Meylan, P.R., Pascual, M., van Delden, C., Bochud, P.Y., University of Zurich, Bochud, Pierre-Yves, Swiss Transplant Cohort Study, Achermann, R., Aubert, JD., Baumann, P., Beldi, G., Benden, C., Berger, C., Binet, I., Bochud, PY., Boely, E., Bucher, H., Bühler, L., Carell, T., Catana, E., Chalandon, Y., de Geest, S., de Rougemont, O., Dickenmann, M., Duchosal, M., Fehr, T., Ferrari-Lacraz, S., Garzoni, C., Gasche, Y., Soccal, PG., Giostra, E., Golshayan, D., Good, D., Hadaya, K., Hess, C., Hillinger, S., Hirsch, HH., Hofbauer, G., Huynh-Do, U., Immer, F., Klaghofer, R., Koller, M., Kuntzen, T., Laesser, B., Lehmann, R., Lovis, C., Manuel, O., Marti, HP., Martin, PY., Meylan, P., Mohacsi, P., Morard, I., Morel, P., Mueller, U., Mueller, NJ., Mueller-McKenna, H., Müller, T., Müllhaupt, B., Nadal, D., Nair, G., Pascual, M., Passweg, J., Ziegler, CP., Rick, J., Roosnek, E., Rosselet, A., Rothlin, S., Ruschitzka, F., Schanz, U., Schaub, S., Seiler, C., Semmo, N., Stampf, S., Steiger, J., Toso, C., Tsinalis, D., Van Delden, C., Venetz, JP., Villard, J., Wick, M., Wilhelm, M., and Yerly, P.

Subjects
10234 Clinic for Infectious Diseases, ddc:616, 10219 Clinic for Gastroenterology and Hepatology, 10036 Medical Clinic, 10209 Clinic for Cardiology, C-Reactive Protein/genetics, Female, Fungi/isolation & purification, Humans, Immunocompromised Host, Male, Mycoses/genetics, Mycoses/immunology, Organ Transplantation/adverse effects, Polymorphism, Genetic, Prospective Studies, Serum Amyloid P-Component/genetics, 610 Medicine & health, 2725 Infectious Diseases, 2726 Microbiology (medical)
Abstract

Donor PTX3 polymorphisms were shown to influence the risk of invasive aspergillosis among hematopoietic stem cell transplant recipients. Here, we show that PTX3 polymorphisms are independent risk factors for invasive mold infections among 1101 solid organ transplant recipients, thereby strengthening their role in mold infection pathogenesis and patients' risk stratification.

Published
2015
Full Text
View/download PDF

43. Influence of IFNL3/4 polymorphisms on the incidence of cytomegalovirus infection after solid-organ transplantation

Author

Stéphanie Bibert, Alexia Cusini, Christian Garzoni, Nicolas J. Mueller, Juerg Steiger, Adrian Egli, Martin Stern, Isabelle Binet, Christoph Berger, Maja Weisser, Hans H. Hirsch, Pierre-Yves Bochud, Manuel Pascual, Agnieszka Wójtowicz, Pascal Meylan, Oriol Manuel, Christian van Delden, University of Zurich, Manuel, Oriol, Swiss Transplant Cohort Study (STCS), Swiss Transplant Cohort Study STCS, Binet, I., De Geest, S., van Delden, C., Hofbauer, G., Huynh-Do, U., Koller, M., Lovis, C., Manuel, O., Meylan, P., Mueller, Nj., Pascual, M., Schaub, S., and Steiger, J.

Subjects
Adult, Male, medicine.medical_specialty, Hepatitis C virus, Cytomegalovirus, 610 Medicine & health, Disease, Virus Replication, medicine.disease_cause, Antiviral Agents, Polymorphism, Single Nucleotide, Gastroenterology, 10234 Clinic for Infectious Diseases, Interferon, Internal medicine, medicine, Humans, Immunology and Allergy, Genetic Predisposition to Disease, Cumulative incidence, Allele, Genetic Association Studies, Aged, ddc:616, ddc:617, business.industry, Incidence, Interleukins, virus diseases, 2725 Infectious Diseases, Middle Aged, Kidney Transplantation, Confidence interval, 3. Good health, Transplantation, Infectious Diseases, 10036 Medical Clinic, Cytomegalovirus Infections, Immunology, 2723 Immunology and Allergy, Female, Interferons, business, Cohort study, medicine.drug
Abstract

© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. Background. Polymorphisms in IFNL3 and IFNL4 the genes encoding interferon ?3 and interferon ?4 respectively have been associated with reduced hepatitis C virus clearance. We explored the role of such polymorphisms on the incidence of cytomegalovirus (CMV) infection in solid organ transplant recipients. Methods. White patients participating in the Swiss Transplant Cohort Study in 2008 2011 were included. A novel functional TT/ G polymorphism (rs368234815) in the CpG region upstream of IFNL3 was investigated. Results. A total of 840 solid organ transplant recipients at risk for CMV infection were included among whom 373 (44) received antiviral prophylaxis. The 12 month cumulative incidence of CMV replication and disease were 0.44 and 0.08 cases respectively. Patient homozygous for the minor rs368234815 allele ( G/ G) tended to have a higher cumulative incidence of CMV replication (subdistribution hazard ratio [SHR] 1.30 [95 confidence interval {CI}. 97 1.74]; P =. 07) compared with other patients (TT/TT or TT/ G). The association was significant among patients followed by a preemptive approach (SHR 1.46 [95 CI 1.01 2.12]; P =. 047) especially in patients receiving an organ from a seropositive donor (SHR 1.92 [95 CI 1.30 2.85]; P =. 001) but not among those who received antiviral prophylaxis (SHR 1.13 [95 CI. 70 1.83]; P =. 6). These associations remained significant in multivariate competing risk regression models. Conclusions. Polymorphisms in the IFNL3/4 region influence susceptibility to CMV replication in solid organ transplant recipients particularly in patients not receiving antiviral prophylaxis.

Published
2015
Full Text
View/download PDF

44. Reply to Cunha et al

Author

Wójtowicz, Agnieszka, Lecompte, Thanh Doco, Bibert, Stéphanie, Manuel, Oriol, Rüeger, Sina, Berger, Christoph, Boggian, Katia, Cusini, Alexia, Garzoni, Christian, Khanna, Nina, Mueller, Nicolas J, Meylan, Pascal R, Pascual, Manuel, Van Delden, Christian, Semmo, Nasser, Beldi, Guido, Bochud, Pierre-Yves, Swiss Transplant, Cohort Study, Swiss Transplant Cohort Study, Achermann, R., Aubert, JD., Baumann, P., Beldi, G., Benden, C., Berger, C., Binet, I., Bochud, PY., Boely, E., Bucher, H., Bühler, L., Carell, T., Catana, E., Chalandon, Y., de Geest, S., de Rougemont, O., Dickenmann, M., Duchosal, M., Fehr, T., Ferrari-Lacraz, S., Garzoni, C., Gasche, Y., Soccal, PG., Giostra, E., Golshayan, D., Good, D., Hadaya, K., Hess, C., Hillinger, S., Hirsch, HH., Hofbauer, G., Huynh-Do, U., Immer, F., Klaghofer, R., Koller, M., Kuntzen, T., Laesser, B., Lehmann, R., Lovis, C., Manuel, O., Marti, HP., Martin, PY., Meylan, P., Mohacsi, P., Morard, I., Morel, P., Mueller, U., Mueller, NJ., Mueller-McKenna, H., Müller, T., Müllhaupt, B., Nadal, D., Nair, G., Pascual, M., Passweg, J., Ziegler, CP., Rick, J., Roosnek, E., Rosselet, A., Rothlin, S., Ruschitzka, F., Schanz, U., Schaub, S., Seiler, C., Semmo, N., Stampf, S., Steiger, J., Toso, C., Tsinalis, D., Van Delden, C., Venetz, JP., Villard, J., Wick, M., Wilhelm, M., Yerly, P., University of Zurich, Bochud, Pierre-Yves, and Chalandon, Yves

Subjects
Male, Microbiology (medical), medicine.medical_specialty, Organ Transplantation / adverse effects, Serum Amyloid P-Component / genetics, 610 Medicine & health, 2726 Microbiology (medical), Organ transplantation, 10234 Clinic for Infectious Diseases, Immunocompromised Host, Internal medicine, medicine, Humans, Serum amyloid P component, ddc:616, Mycoses / immunology, Polymorphism, Genetic, Fungi / isolation & purification, biology, business.industry, C-reactive protein, Fungi, Organ Transplantation, 2725 Infectious Diseases, Mycoses / genetics, Serum Amyloid P-Component, C-Reactive Protein, Infectious Diseases, Endocrinology, Mycoses, 10209 Clinic for Cardiology, biology.protein, C-Reactive Protein / genetics, Female, business, C-Reactive Protein/genetics, Fungi/isolation & purification, Mycoses/genetics, Mycoses/immunology, Organ Transplantation/adverse effects, Serum Amyloid P-Component/genetics
Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results