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This study aims to determine the impact of the COVID-19 pandemic on the financial performance of airlines as seen based on the ratio of liquidity, solvency, activity, and profitability. The subjects in this study were airlines listed on the IDX, which consisted of 3 companies, namely PT Garuda Indonesia (Persero) Tbk, PT Air Asia Indonesia Tbk, and PT Indonesia Transport Infrastructure Tbk. The data collection technique in this research is data documentation which comes from www.idx.co.id. The results of this study indicate that the COVID-19 pandemic has a negative impact on the financial performance of airlines. The decline in financial performance was marked by a decrease in the calculation results of the liquidity ratio, activity and profitability as well as an increase in the calculation results of the solvency ratio. Of the three airlines listed on the IDX, PT Air Asia Indonesia Tbk is the airline that experienced the greatest impact due to the COVID-19 pandemic, this is because prior to the COVID-19 pandemic, PT Air Asia Indonesia Tbk's business activities were mostly on outside travel. country, but at the time of the COVID-19 pandemic, many countries closed their access to foreign flights. While PT Indonesia Transport Infrastructure Tbk is an airline company whose financial performance has only experienced the least impact of the COVID-19 pandemic when compared to PT Air Asia Indonesia Tbk and PT Garuda Indonesia (Persero) Tbk because most of these business activities in this company are the transportation of goods such as oil and gas.

Objective: To determine the relationship between the Serotonin transporter SLC6A4 (5-HTTLPR) gene polymorphism in cheilitis angularis patients. Material and Methods: We conducted a descriptive analysis of 100 DNA samples extracted from the blood serum of 50 patients with cheilitis angularis and 50 patients without cheilitis angularis. Analysis of the Serotonin transporter SLC6A4 (5-HTTLPR) gene polymorphism was observed by carrying out PCR method followed by electrophoresis for the analysis, without the usage of restriction enzyme. The Chi-square test was used for statistical analysis. Results: In the cheilitis angularis group there were 24 samples with SS genotype, 23 samples with LS genotype, and 3 samples with LL genotype. Whereas in the non-cheilitis angularis group, there were 5 samples with SS genotype, 18 samples with LS genotype, and 27 samples with LL genotype. In the cheilitis angularis group found 71 S alleles and 29 L alleles, and in the non-cheilitis angularis group 28 S alleles and 72 L alleles were found. A statistically significant difference was found between the groups (p

Objective: To evaluate the possible association of a polymorphism in the gene encoding methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), 1958G>A, with the susceptibility to orofacial cleft in an Indonesian population. Material and Methods: A total of 200 stored secondary biological samples from 30 cases of orofacial cleft and 170 unaffected controls were analyzed to determine the polymorphism status at base 1958. The analysis was conducted using the PCR-restriction fragment length polymorphism technique after digestion with the Msp1 restriction enzyme . The samples were then subjected to agarose gel electrophoresis to investigate the presence or absence of the following fragments: genotype GG, 196, 86 and 40 base pairs (bp); genotype AA, 282 and 28 bp and genotype AG, 282, 196, 86, 40 and 28 bp. The test groups were compared using the Chi-square test. Results: The wild-type allele containing 1958G, as well as the genotype GG, were significantly more common in the control group than in the orofacial cleft group. Conclusion: The MTHFD1 1958G>A polymorphism was significantly associated with orofacial cleft susceptibility in the tested Indonesian population.