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To verify characteristics associated with drug resistant epilepsy in children up to 36 months of age with Congenital Zika Syndrome (CZS).This is a prospective cohort study with children aged up to 36 months diagnosed with CZS. Obstetric, demographic, phenotype and other clinical signs, cranial tomography, growth and motor development of the children were collected.Of a total of 109 children diagnosed with CZS, 100 (91.7%) had epilepsy and 68 (68%) with drug resistant seizures. The types of seizures associated with drug resistant epilepsy were focal seizures from the occipital lobe, generalized tonic and generalized tonic-clonic seizures. There was an association between drug resistant epilepsy and microcephaly at birth, severe microcephaly at birth, excess nuchal skin, ventriculomegaly, reduced brain parenchyma volume, and hypoplasia or malformation of the cerebellum. Difficulty sleeping, irritability, continuous crying, dysphagia and gross motor function were clinical signs associated with drug resistant epilepsy, as were the presence of ocular abnormalities, low head circumference in the first year of life and low weight in the first six months.The prevalence of drug resistant epilepsy in children up to 36 months with CZS was 62.4% and was associated with the severity of the child's neurological damage, with emphasis on the reduction of brain parenchyma volume and damage to the cerebellum.

O objetivo deste estudo foi compreender a perspectiva de médicos acerca do processo de trabalho em Clínicas Populares de Saúde. Para isso, realizamos uma pesquisa qualitativa na qual foram entrevistados oito jovens médicos especialistas que atuam nessas empresas em São Luís, Maranhão. Identificamos condições precarizadas de trabalho, mas com pouca resistência por parte dos médicos, considerando que essas empresas são encaradas como espaços de projeção no mercado de trabalho local. Devido às limitações do modelo assistencial do tipo queixa-conduta, os entrevistados acionam uma rede informal e os usuários das Clínicas Populares de Saúde são encaminhados para o Sistema Único de Saúde (SUS). Assim, o processo de trabalho do médico é desafiado por esse modelo assistencial fragmentado, o que faz borrar os limites nas interfaces público-privado na medida em que uma dupla porta de entrada para o SUS é naturalizada.

The objective of the study was to understand the perspective of doctors regarding the work process in Low-cost Health Clinics. To this end, we conducted qualitative research interviewing 8 young specialist doctors who work in these business firms in São Luís, Maranhão. We identified precarious working conditions, although presenting little resistance from the doctors, considering that these businesses are seen as spaces of projection in the local job market. Due to the limitations of the complaint-driven model of care, the interviewees activate an informal network, and the users of the Low-Cost Health Clinics are referred to the Brazilian National Health System (SUS). Thus, the physician’s work process is challenged by this fragmented care model, which blurs the boundaries in the public-private interfaces leading to a naturalized double gateway to the SUS.

Background The use of telemedicine, or the provision of healthcare and communication services through distance-based technologies, has increased substantially since the 2019 novel coronavirus (COVID-19) pandemic. However, it is still unclear what are the innovative features of the widespread use of such modality, its forms of employment and the context in which it is used across pluralist health systems, particularly in low- and middle-income settings. We have sought to provide empirical evidence on the above issues by analysing the responses of medical doctors in a representative cross-sectional survey in two states in Brazil: São Paulo and Maranhão. Methods We analysed the responses of 1,183 physicians to a survey on the impact of COVID-19 on their livelihood and working practice. Two independent samples per state were calculated based on a total of 152,511 active medical registries in São Paulo and Maranhão. Proportional stratified sampling was performed and the distributions for gender, age, state and location of address (capital or countryside) were preserved. The survey contained questions on the frequency of physicians’ employment of telemedicine services; the specific activities where these were employed, and; the forms in which the pandemic had influenced the adoption or consolidation of this technology. We performed descriptive and univariate analysis based on the chi-square test or Fisher's exact test for the qualitative data, and the Mann–Whitney test in the quantitative cases. Data were shown as absolute frequency and proportion with a 95% confidence interval. Results In our sample of physicians, telemedicine was employed as a form of clinical collaboration by most doctors (76.0%, 95 CI 73.6–78.5), but only less than a third of them (30.6%, 95 CI 28.0–33.3) used it as a modality to provide healthcare services. During the pandemic, telemedicine was used predominantly in COVID-19-related areas, particularly for hospital-based in-patient services, and in private clinics and ambulatory settings. Male, younger doctors used it the most. Doctors in São Paulo employed telemedicine more frequently than in Maranhão (p p Conclusions Our study suggests that telemedicine may have helped ensure and expand the range of communication and healthcare services in low- and middle-income settings during the COVID-19 pandemic. However, the modality appears to lend itself to be disproportionally used by doctors working in specific, priviledged sections of pluralistic health systems, and presumably by patients seeking care there. Regulation and incentives will be required to support the use of the technology across health systems in low- and middle-income countries in order to increase access to services for less disadvantaged populations.

Objectives: to analyze the prevalence and factors associated with unplanned pregnancy in a Brazilian capital in the Northeast. Methods: a cross-sectional study nested to a hospital birth cohort with a probable sample of 5,110 puerperal women. Associated factors were analyzed using a hierarchical theoretical model in three levels: distal (women’s socioeconomic and demographic characteristics), intermediate (reproductive characteristics, maternal habits and BMI), and proximal level (partner's characteristics). Multivariate Poisson regression analysis was performed. Results: the prevalence of unplanned pregnancy was 68.1% (CI95%=66.8-69.4). Multivariate analysis showed association with black skin color/race (PR=1.03; CI95%=1.01- 1.07), mother's age group up to 19 years old (PR=1.09; CI95%=1.06-1.12) and 20 to 24 years old (PR=1.04; CI95%=1.01-1.07), not living with partner (PR=1.09; CI95%=1.07- 1.11), highest number of people in the household: 5 people (PR= 1.10; CI95%=1.08-1.13) and 3 to 4 (PR=1.08; CI95%=1.05-1.10), number of ≥4 children (PR=1.09; CI95%=1.06- 1.13) and 2 or 3 children (PR=1.03; CI95%=1.02-1.05), alcohol consumption (PR=1.03; CI95%=1.01-1.05), malnourished pre-pregnancy BMI (PR=1.03; CI95%=1.01-1.06) and partner’s low schooling (5 to 8 years) (PR=1.03; CI95%=1.01-1.07). Prior abortion was inversely associated with planned pregnancy (PR=0.95; CI95%=0.93-0.97). Conclusions: the prevalence of unplanned pregnancy was high and was associated with socioeconomic and demographic characteristics that reflect on the combination of the complex inequalities that impact women and their partners

The COVID-19 pandemic has impacted public and private health systems around the world, impairing good practices in women’s health care. However, little is known about the experiences, knowledge, and feelings of Brazilian women in this period. The objective was to analyze the experiences of women, seen at maternity hospitals accredited by the Brazilian Unified Health System (SUS, acronym in Portuguese), regarding health care during pregnancy, childbirth, and postpartum periods, their interpersonal relationships, and perceptions and feelings about the pandemic. This was a qualitative, exploratory research, carried out in three Brazilian municipalities with women hospitalized in 2020, during pregnancy, childbirth, or postpartum period, with COVID-19 or not. For data collection, semi-structured individual interviews (in person, by telephone, or by digital platform) were conducted, recorded and transcribed. The content analysis of thematic modalities was displayed as per the following axes: i) Knowledge about the disease; ii) Search for health care in prenatal, childbirth, and postpartum periods; iii) Experience of suffering from COVID-19; iv) Income and work; and v) Family dynamics and social support network. A total of 46 women were interviewed in São Luís-MA, Pelotas-RS, and Niterói-RJ. Use of media was important to convey information and fight fake news. The pandemic negatively impacted access to health care in the prenatal, childbirth, and postpartum periods, contributing to worsening of the population’s social and economic vulnerabilities. Women experienced diverse manifestations of the disease, and psychic disorders were very frequent. Social isolation during the pandemic disrupted the support network of these women, who found social support strategies in communication technologies. Women-centered care–including qualified listening and mental health support–can reduce the severity of COVID-19 cases in pregnant, parturient, and postpartum women. Sustainable employment and income maintenance policies are essential to mitigate social vulnerabilities and reduce risks for these women.

To estimate the prevalence of social participation (exposure) and its association with positive self-assessment of overall health status (SAH) (outcome) among 7,712 Brazilian elderly interviewed in the National Health Survey 2013. A cross-sectional study that used Propensity Score (PS) to improve comparability between the group exposed and no exposed to social participation. Poisson regression was performed to determine the prevalence and association of interest using crude and adjusted by inverse probability of selection of PS. Social participation was reported by 25.1% (CI95%: 23.4-26.9) and was lower among poor older people, who depend on public transportation and live in more precarious contexts. Most did not SAH positively, but the proportion was higher when they had social participation (48.0%; CI95%: 46.0-51.0). There was a positive association of social participation with SAH positive. The association using the adjusted model (PR: 1.15; CI95%: 1.08-1.22) attenuated the estimated in the crude model. Elderly exposed were 15% more likely to provide a positive SAH. Despite low levels in Brazil, there was a positive association between of social participation and SAH, confirming that engagement in such activities provides important gains for the health and quality of life. Resumo Estimar a prevalência da participação social (exposição) e sua associação com a autoavaliação positiva do estado de saúde (AAS) (desfecho) de 7.712 idosos entrevistados na Pesquisa Nacional de Saúde 2013. Trata-se de estudo transversal que usou o Escore de Propensão (EP) para melhorar a comparação entre o grupo exposto e não exposto a participação social. Realizou-se regressão de Poisson para determinar a prevalência e associação em estudo com o modelo bruto e ajustado pelo inverso da probabilidade de seleção do EP. A participação social foi referida por 25,1% (IC:95%: 23,4-26,9) e foi menor entre os idosos pobres, que dependem de transporte público e vivem em contextos mais precários. A maioria não avaliou positivamente sua saúde, mas a proporção foi maior quando tem participação social (48,0%; IC95%: 46,0-51,0). Houve associação positiva da participação social com a AAS positiva. A magnitude de associação usando o modelo ajustado (RP: 1,15; IC95%: 1,08-1,22) atenuou a estimada no modelo bruto. Idosos expostos tiveram 15% a mais de chance de referir AAS positiva. Apesar de baixa prevalência no Brasil, houve positiva influência da participação social na avaliação de saúde, confirmando que o engajamento social permite ganhos importantes para a saúde e qualidade de vida.

Women face difficulties in accessing post-abortion care, as hierarchical care operates under discrimination mechanisms that condemn women in abortion. In addition, it is the Black and Brown women who are more subject to unsafe abortions and need hospitalization to complete the termination of pregnancy or treat associated complications. This study aimed at identifying factors associated with the institutional barriers in access to health services for women who underwent abortion by race/color. The survey encompassed 2640 users admitted to public hospitals in Salvador, Recife, and Sao Luis. Differences among covariables according to race/color (Black, Brown, and White women) were analyzed and tested for statistical significance using Pearson’s χ2 test. The regression analysis initially included variables that may express the technical criteria of priority in care (time of pregnancy when abortion occurred and conditions of arrival), then the sociodemographic characteristics, and, lastly, the type of abortion declared. Black women faced more institutional difficulties (27.7% vs 19.5% in White women and 18.7% in Brown women), such as waiting to be attended and getting a bed. The association between being Black women and institutional barriers remained, even after adjustments in the regression model. Institutional racism limits access to health services and timely care for Black women, acting as a performative mechanism, legitimizing and generating exclusionary behaviors. The results demonstrate that the intersection between racial discrimination and abortion stigma redouble institutional barriers that are denominated intersectional discrimination.

Background Little information on gross motor function of congenital Zika syndrome (CZS) children is available. Objectives To evaluate gross motor function in CZS children aged up to 3 years, and its associated factors and changes in a minimum interval of 6 months. Methods One hundred children with CZS and cerebral palsy (36 with confirmed and 64 with presumed CZS) were evaluated with the Gross Motor Function Classification System (GMFCS) and Gross Motor Function Measure (GMFM-88/GMFM-66). Forty-six were reevaluated. Wilcoxon tests, Wilcoxon tests for paired samples, percentile scores, and score changes were performed. Results Clinical and socioeconomic characteristics (except maternal age), GMFM scores and GMFCS classification of confirmed and probable cases, which were analyzed together, were similar. The mean age was 25.6 months (±5.5); the median GMFM-88 score was 8.0 (5.4–10.8); and the median GMFM-66 score was 20.5 (14.8–23.1); 89% were classified as GMFCS level V. Low economic class, microcephaly at birth, epilepsy, and brain parenchymal volume loss were associated with low GMFM-66 scores. The median GMFM-66 percentile score was 40 (20–55). On the second assessment, the GMFM-66 scores in two GMFCS level I children and one GMFCS level IV child improved significantly. In one GMFCS level III child, one GMFCS level IV child, and the group of GMFCS level V children, no significant changes were observed. Conclusions Almost all CZS children had severe cerebral palsy; in the third year of life, most presented no improvement in gross motor function and were likely approaching their maximal gross motor function potential.

Objective To assess the direct, indirect, and total effects of violence during pregnancy on perinatal outcomes, and to evaluate the effect of violence as a moderator of the mediated relationship of depression with perinatal outcomes. Methods Data was collected from the prenatal study and follow-ups of the BRISA cohort, São Luís, Maranhão, Brazil. The perinatal outcomes investigated were: birth weight (BW), intrauterine growth restriction (IUGR) and gestational age (GA). Violence against women was evaluated using the World Health Organization Violence against Women instrument (Violence during pregnancy – regardless of the type of violence; Physical violence during pregnancy; Psychological violence during pregnancy). Depressive symptoms during pregnancy were evaluated as a mediating variable. Moderated mediation analysis was performed to estimate the effects of violence and depression on perinatal outcomes. Results Three types of violence analyzed by depression had an indirect effect in BW and GA. None of the types of violence showed an association with IUGR. All types of violence analyzed showed a moderated mediation effect with BW and GA. Only among women who experienced violence were birth weight and gestational age lower the higher the values of depressive symptoms. Conclusion Violence and depression are only associated with lower BW and GA when they occur simultaneously.

RESUMO Objetivo: analisar mudanças na assistência à saúde materna durante a pandemia da Covid-19, segundo relatos dos profissionais de saúde. Método: pesquisa qualitativa, realizada com gestores, médicos, enfermeiros, residentes e técnicos de enfermagem atuantes nos setores de ambulatório de pré-natal, emergência obstétrica, hospitalização obstétrica e centro de parto de um hospital público federal de alta complexidade no Nordeste do Brasil. Os dados foram coletados de no período de dezembro de 2020 a agosto de 2021. A amostra, escolhida intencionalmente, buscou a diversidade de características e situações, foi encerrada pelo critério da saturação de sentidos. Questionário estruturado e roteiro semiestruturado de entrevista foram utilizados para coleta dos dados. As entrevistas foram gravadas e transcritas. Empregou-se a análise de conteúdo, na modalidade temática. Resultados: entrevistaram-se 28 profissionais. Foram identificadas mudanças na dinâmica da assistência obstétrica categorizadas em: pré-natal; e parto/puerpério. No pré-natal, houve diminuição das consultas eletivas; aumento do tempo entre consultas; a paramentação atrasava o atendimento; implantação de novos protocolos de higienização; limitação do número de acompanhantes; criação de novos ambientes como a sala Covid-19 para gestantes sintomáticas; teleatendimento e sobrecarga de trabalho pelo aumento da demanda vinda da Atenção Primária à Saúde. No parto/puerpério, os relatos apontaram redução do número de leitos; testagem e isolamento das pacientes sintomáticas; limitação da deambulação, restrição de acompanhantes e obrigatoriedade do uso de máscara pela parturiente. Conclusão: a reestruturação dos serviços e a criação de novos espaços para atendimento de pacientes com Covid-19 ocasionaram redução na oferta de vagas para consultas de pré-natal e pós-parto. As mudanças foram acompanhadas por novas regras de atendimento, com retrocessos quanto à garantia de direitos previamente conquistados.

Objective: to analyze changes in maternal health care during the Covid-19 pandemic, according to reports by health professionals. Method: qualitative research, conducted with managers, physicians, nurses, residents and nursing technicians working in a prenatal outpatient clinic, obstetric emergency department, delivery center and obstetric inpatient ward of a high complexity federal public hospital in the Northeast of Brazil. Data were collected from December 2020 to August 2021. The sample, chosen intentionally, sought the diversity of characteristics and situations, was closed by the criterion of saturation of meaning. A structured questionnaire and a semi-structured interview script were used for data collection. The interviews were recorded and transcribed. Content analysis was used in the thematic modality. Results: 28 professionals were interviewed. Changes in the dynamics of obstetric care were identified and categorized as: prenatal care; and childbirth/postpartum. In prenatal care, there was a decrease in elective consultations; increased time between consultations; delayed care due to paramentation; implementation of new hygiene protocols; limitation of the number of companions; creation of new environments such as the Covid-19 isolation room for symptomatic pregnant women; teleservice and work overload due to the increased demand coming from Primary Health Care. In childbirth/postparum, the reports indicated a reduction in the number of beds; testing and isolation of symptomatic patients; limitating walking, restriction of companions and mandatory use of mask by pregnant woman. Conclusion: the restructuring of services and the creation of new spaces to care for patients with Covid-19 led to a reduction in the availability of vacancies for prenatal and postpartum consultations. The changes were accompanied by new service rules, with setbacks regarding the guarantee of rights.

Objective: to know the perspectives, practices and challenges in decision-making for admitting patients into the Intensive Care Unit during the Covid-19 pandemic. Methods: a qualitative study developed in two public hospitals in Maranhão, Brazil, from November/2020 to January/2021. Data collection took place through individual interviews guided by a script. A total of 22 professionals participated in the study: nurses and doctors who worked in the Intensive Care Unit and Bed Regulation in the first wave of the pandemic. Content Analysis was used in the thematic mode, with support from the Qualitative Data Analysis software program for data categorization. The theory of Responsibility for Reasonableness guided the study. Results: two main categories emerged: “The context of the decision-making process - the paradox of celestial discharges” and “Decision-making for admission”. In the scenario of high demand, a lack of beds, and the uncertainties of the “new disease”, deciding who would occupy the bed was arduous and conflicting. Clinical and non-clinical criteria such as severity, chance of survival, distance to be covered and transport conditions were considered. It was found that the ambivalence of feelings attributed to death and care at that moment of the pandemic marked the social and technical environment of intensive care. Conclusions: the complexity of the decision-making process for admission to an intensive care unit was evidenced, demonstrating the importance of analyzing the allocation of critical resources in pandemic scenarios. Knowing the perspectives of professionals and their reflections on the experiences in that period can help in planning the allocation of health resources in future emergency scenarios.

This study aimed to analyze sociodemographic and reproductive factors associated with childbirth care in health services affiliated with the Stork Network in Brazil, from the users' perspective. The sample included 10,540 postpartum women from 606 services. The outcome was the latent variable reception of the patient, consisting of five indicators: healthcare staff members introducing themselves stating their names and roles, calling the pregnant woman by her name, the patient's understanding of the information provided, the patient feeling well treated and respected, and the patient having her needs met by the staff. The explanatory variables were maternal age, schooling, skin color, marital status, type of delivery, parity, and number of services visited before admission for childbirth. Most of the women were 20 to 34 years of age (68.31%), self-identified as brown (56.3%), had 9 to 11 years of schooling (56.1%), and were married or lived with the partner (78.8%). There was a predominance of vaginal delivery (56.6%), with one or two previous children (46%), and reports of not having gone to more than one maternity service to be admitted (91.9%). There was a direct positive effect on reception for childbirth from patient´s higher age (SC = 0.094; p0.001) and more schooling (SC = 0.096; p0.001). Cesarean delivery had a direct negative effect (SC = -0.059; p0.002), and black and brown skin color had direct and indirect negative effects (SC = -0.081; p0.001 and SC = -0.014; p0.001). Older postpartum women and those with more schooling and vaginal delivery had a more positive perception of their reception by maternity services.Este estudo objetivou analisar os fatores sociodemográficos e reprodutivos associados ao acolhimento ao parto em estabelecimentos de saúde vinculados à Rede Cegonha no Brasil, na perspectiva das usuárias. Foram selecionados 606 serviços com amostra de 10.540 puérperas. O desfecho foi a variável latente acolhimento da puérpera, composta por cinco indicadores: apresentação dos profissionais com nome e função, chamar a gestante pelo nome, compreensão das informações dadas, se sentir bem tratada e respeitada e ter as necessidades respondidas pela equipe. As variáveis explicativas foram: idade, escolaridade, cor da pele, situação conjugal, tipo de parto, paridade e peregrinação. Foi utilizada modelagem de equações estruturais. Observaram-se maiores percentuais de mulheres com idade de 20 a 34 anos (68,31%), que se autodeclararam como pardas (56,3%), com escolaridade entre 9 e 11 anos de estudo (56,1%) e que tinham companheiro (78,8%). Houve predominância de puérperas que tiveram parto vaginal (56,6%), com um a dois filhos (46%) e que relataram não peregrinar (91,9%). Apresentaram efeito direto positivo sobre o acolhimento mulheres com maior idade (CP = 0,094; p0,001) e maior escolaridade (CP = 0,096; p0,001). O parto cesáreo apresentou efeito direto negativo (CP = -0,059; p0,002) e cor da pele preta e parda apresentou efeitos direto e indireto negativos (CP = -0,081; p0,001 e CP = -0,014; p0,001). Puérpera com maior idade, maior escolaridade e que tiveram parto vaginal tiveram percepção mais positiva do acolhimento nos serviços de saúde.El objetivo de este estudio fue analizar los factores sociodemográficos y reproductivos, asociados a la acogida en el parto, en establecimientos de salud vinculados a la Red Cegonha en Brasil, desde la perspectiva de las usuarias. Se seleccionaron 606 servicios en una muestra de 10.540 puérperas. El resultado fue la variable latente de acogida de la puérpera, compuesta por cinco indicadores: presentación de los profesionales con nombre y función, llamar a la gestante por el nombre, comprensión de la información proporcionada, sentirse bien tratada y respetada y contar con las necesidades cubiertas por el equipo. Las variables explicativas fueron: edad, escolaridad, color de piel, situación conyugal, tipo de parto, paridad y desplazamientos largos. Se utilizó un modelado de ecuaciones estructurales. Se observaron mayores porcentajes de mujeres con una edad comprendida entre los 20 a los 34 años (68,31%), que se autodeclararon mestizas (56,3%), con una escolaridad entre 9 y 11 años de estudio (56,1%) y que tenían compañero (78,8%). Hubo una predominancia de puérperas que tuvieron un parto vaginal (56,6%), con de 1 a 2 hijos (46%) y que informaron no realizar grandes desplazamientos (91,9%). Presentaron un efecto directo positivo sobre la acogida mujeres con mayor edad (CP = 0,094; p0,001) y mayor escolaridad (CP = 0,096; p0,001). El parto por cesárea presentó un efecto directo negativo (CP = -0,059; p0,002) y color de la piel negra y mestiza presentó efectos directo e indirecto negativos (CP = -0,081; p0,001 e CP = -0,014; p0,001). Puérperas con mayor edad, mayor escolaridad y que tuvieran parto vaginal tuvieron una percepción más positiva de acogida en los servicios de salud.

A presença de acompanhante de livre escolha durante o parto é uma prática humanizada percebida de forma positiva pelas mulheres que a vivenciam. Este artigo analisou os desejos, expectativas e experiências de mulheres no período gravídico-puerperal em relação à presença de acompanhante de livre escolha durante o parto. Realizamos pesquisa qualitativa em Hospital Universitário de capital do nordeste brasileiro a partir entrevistas no pré-natal e no pós-parto, observação no momento do parto e consulta em prontuário. Os dados foram analisados através da Análise de Conteúdo, na modalidade temática. Participaram da pesquisa 18 mulheres. As categorias identificadas foram “O desejo por ter acompanhante”, “Expectativa: incerteza pela presença de acompanhante de livre escolha” e “Experiência: a presença de acompanhante como um direito em construção”. As mulheres desejavam a presença de acompanhante mas as expectativas demonstraram incerteza quanto à presença desta figura durante o parto. As mulheres desejavam, na maioria, ter o companheiro como acompanhante. As experiências demonstraram que todas tiveram acompanhante, porém não em todos os momentos do parto. Consideramos que os desejos com relação à presença de acompanhante foram distintos das expectativas; algumas destas expectativas mostraram-se congruentes às experiências. A implementação integral da prática estudada ainda se mostra um desafio.

Evidence exists on the health impacts of the current COVID-19 pandemic on health workers, but less is known about its impact on their work dynamics and livelihoods. This matters, as health workers—and physicians in particular—are a scarce and expensive resource in low- and middle-income countries (LMICs). Our cross-sectional survey set out to explore changes in working hours and earnings during the second year of the pandemic in a representative sample of 1183 physicians in Brazil’s São Paulo (SP) and Maranhão (MA) states. Descriptive analysis and inferential statistics were employed to explore differences in working hours and earnings among public and private sector physicians across the two locations. The workloads and earnings of doctors working exclusively in the public sector increased the most in the second year of the epidemic, particularly in MA. Conversely, the largest proportion of private-only doctors in our sample saw a decrease in their working hours (48.4%, 95% CI 41.8–55.0), whereas the largest proportion of public-only doctors in MA saw an increase in their working hours (44.4%, 95% CI 38.0–50.8). Although earnings remained broadly stable in the public sector, a third of public sector-only physicians in MA saw an increase in their earnings (95% CI 24.4–36.2). More than half of private-only doctors across both states saw a decrease in their earnings (52.2%, 95% CI 45.6–58.8). The largest proportion of dual practitioners (the majority in Brazil and in our sample) maintained their pre-pandemic levels of income (38.8%, 95% CI 35.3–42.3). As public-sector doctors have been key in the fight against the pandemic, it is critical to invest in these cadres in order to develop epidemic preparedness in LMICs, and to find new ways to harness for-profit actors to deliver social benefits.

This article aims to assess the prevalence and factors associated with self-medication in adolescents. Cross-sectional study, nested in cohort, with 2,515 adolescents aged 18-19 years born in São Luís-MA. The use of medication in the last 15 days without a medical prescription or by a qualified professional was considered self-medication. Factors associated with self-medication were evaluated using Poisson regression with robust variances and hierarchical selection of variables. Medicines were used in the last 15 days by 48.05% of adolescents. Among these, 70.09% use it without a prescription or indication from another health professional. The most used medications for self-medication were “over the counter” (93.68%). Self-medication was positively associated with female gender (PR: 1.41; 95%CI: 1.25-1.59), screen time ≥5h/day (PR: 1.32; 95%CI: 1.05-1.67) and self-reported diagnosis of allergic rhinitis (PR: 1.19; 95%CI: 1.02-1.39); however, negatively associated with self-satisfaction with health (PR: 0.79; 95%CI: 0.67-0.94) and hospitalization in the previous year (PR: 0.70; 95%CI: 0.50-0.97). Self-medication was common among adolescents and to reduce this practice, greater attention should be given to women, individuals with intense exposure to meshes and allergic diseases.

OBJECTIVES: To estimate the prevalence and factors associated with hesitancy in getting the vaccine against SARS-CoV-2 in Maranhão, Brazil. METHODS: This is a cross-sectional population-based study conducted from October 19 to 30, 2020. The estimates were calculated based on clustering, stratification, and non-response. A three-stage sampling was adopted, considering stratum, census tracts, and domicile. After systematic analysis, thirty sectors were selected in each stratum, totaling 150 sectors. Each sector contained a fixed number of 34 households, thus totaling 5,100 households. One individual within each household (resident for at least six months and aged one year or more) was selected by a simple random sampling. We questioned participants about their vaccination intention. Univariate association between independent variables and the outcome were verified using descriptive analysis (weighted frequencies) and Pearson's chi-square test (p < 0.05). Robust multivariate analysis was performed using a three-level hierarchical model. RESULTS: We found 17.5% (95%CI 16.1–19.1%) of the 4,630 individuals interviewed to report hesitancy to be vaccinated against covid-19. After final model adjustment, vaccination hesitancy was statistically higher among residents of the cities of Imperatriz (24.0%; RP = 1.48; IC95% 1.09–2.02) and municipalities of the Grande Ilha de São Luís (20.7%; RP = 1.34; 95%CI 1.02–1.76), female individuals (19.8%; RP = 1.44; 95%CI 1.20–1.75), older adults (22.8%; RP = 1.79; IC95% 1.30–2.46), evangelicals (24.1%; RP = 1.49; 95%CI 1.24–1.79), and those without reported symptoms (18.6%; RP = 1.24; 95%CI 1.02–1.51). We found no statistical differences for other socioeconomic and demographic characteristics, as well as variables related to the labor market, behaviors, and health conditions of the interviewees. CONCLUSION: The prevalence of vaccine hesitancy in Maranhão and its association with individual, contextual, and clinical factors enable us to identify the groups and contexts of greatest resistance, requiring special attention from public strategies to ensure wide vaccination.

The study analyzed the impact of psychological violence on the development of posttraumatic stress disorder (PTSD). This was a cross-sectional study nested in a cohort in which the second follow-up was conducted in 2016. A questionnaire was applied to 2,486 adolescents and approached individual, family, and social aspects and experience with psychological violence. Propensity score was used to create inverse probability weighting (IPW). Thus, a probability was assigned to each adolescent, where 1/IPW represent those in the exposed group and 1/(1-IPW) those in the unexposed group. This procedure made the two groups more homogeneous and mutually comparable. The association between the occurrence of psychological violence and PTSD was estimated by odds ratios (OR) and 95% confidence intervals (95%CI) via crude binary logistic regression and adjusted logistic regression (weighted by IPW). According to the results, 30.3% reported having suffered severe violence. Prevalence of PTSD was 4.8% among exposed and 1.5% in unexposed to psychological violence. An association was observed between severe violence and PTSD in the two analyses, but the magnitude in the model structured by the propensity score (OR = 1.97; 95%CI: 1.08-3.56) indicated an adjustment to the measure from the crude analysis (OR = 3.40; 95%CI: 2.03-5.69). The current study contributes to the scarce literature on exposure to psychological violence and its association with the development of PTSD, confirming the negative impact of this form of abuse on the individual´s mental health.Este trabalho analisou a influência da ocorrência de violência psicológica no desenvolvimento de transtorno de estresse pós-traumático (TEPT) em adolescentes. Tratou-se de um estudo transversal aninhado a uma coorte, cujo segundo segmento foi realizado em 2016. Aplicou-se um questionário em 2.486 adolescentes, por meio do qual se abordou aspectos individuais, familiares, sociais e da vivência de violência psicológica. Utilizou-se o escore de propensão para se criar o inverso da probabilidade de seleção (IPS). Dessa forma, atribuiu-se uma probabilidade para cada adolescente, sendo 1/IPS aqueles que compõem o grupo dos expostos e 1/(1-IPS) aqueles do grupo dos não expostos. Essa condição tornou os dois grupos mais homogêneos e comparáveis entre si. A associação entre a ocorrência de violência psicológica e de TEPT foi estimada pela odds ratio (OR), enquanto o intervalo de 95% de confiança (IC95%) foi estimado por meio da regressão logística binária bruta e ajustada, ponderada pelo IPS. Verificou-se que 30,3% relataram ter sofrido violência severa. A prevalência do TEPT foi de 4,8% entre os expostos contra 1,5% entre os não expostos à violência psicológica. Observou-se uma associação da violência severa com o TEPT nas duas análises realizadas. Porém, a magnitude no modelo estruturado pelo escore de propensão (OR = 1,97; IC95%: 1,08-3,56) indicou um ajuste da medida de associação da análise bruta (OR = 3,40; IC95%: 2,03-5,69). Nesse sentido, este estudo contribui para a escassa literatura sobre a exposição à violência psicológica e a sua associação com o desenvolvimento de TEPT, confirmando o impacto negativo dessa forma de abuso na saúde mental do indivíduo.Se analizó la influencia de la ocurrencia de violencia psicológica en el desarrollo de trastorno de estrés postraumático (TEPT). Se trató de un estudio transversal anidado en una cohorte, cuyo segundo seguimiento se realizó en 2016. Se aplicó un cuestionario en 2.486 adolescentes, a través del cual se abordaron aspectos individuales, familiares, sociales, así como de vivencia de violencia psicológica. Se utilizó el marcador de propensión para que se creara el inverso de la probabilidad de selección (IPS). De esta forma, se atribuyó una probabilidad para cada adolescente, siendo 1/IPS para aquellos que componen el grupo de expuestos y 1/(1-IPS) para aquellos del grupo no expuestos. Esta condición hizo los dos grupos más homogéneos y comparables entre sí. La asociación entre ocurrencia de violencia psicológica y TEPT se estimó mediante OR (odds ratio) y el IC95% (intervalo de 95% de confianza) por medio de la regresión logística binaria bruta y ajustada (ponderada por el IPS). Se verificó que un 30,3% informaron haber sufrido violencia severa. La prevalencia del TEPT fue de un 4,8% entre los expuestos contra un 1,5% en no expuestos a la violencia psicológica. Se observó una asociación de la violencia severa con el TEPT en los dos análisis realizados, no obstante, la magnitud en el modelo estructurado por el marcador de propensión (OR = 1,97; IC95%: 1,08-3,56) indicó un ajuste de la medida de asociación del análisis bruto (OR = 3,40; IC95%: 2,03-5,69). Este estudio contribuye a la escasa literatura sobre la exposición de violencia psicológica y su asociación con el desarrollo del TEPT, confirmando el impacto negativo de esa forma de abuso en la salud mental del individuo.

SummaryBackgroundFew population-based studies on the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been performed to date, and most of them have used lateral flow immunoassays with finger-prick, which may yield false-negative results and thus underestimate the true infection rate.MethodsA population-based household survey was performed in the State of Maranhão, Brazil, from 27 July 2020 to 8 August 2020 to estimate the seroprevalence of SARS-CoV-2 using a serum testing electrochemiluminescence immunoassay. A three-stage cluster sampling stratified by four state regions was used. The estimates took clustering, stratification, and non-response into account. Qualitative detection of IgM and IgG antibodies was performed in a fully-automated Elecsys® Anti-SARS-CoV-2 electrochemiluminescence immunoassay on the Cobas® e601 analyser (Roche Diagnostics).FindingsA total of 3156 individuals were interviewed. Seroprevalence of total antibodies against SARS-CoV-2 was 40·4% (95%CI 35·6-45·3). Population adherence to non-pharmaceutical interventions was higher at the beginning of the pandemic than in the last month. SARS-CoV-2 infection rates were significantly lower among mask wearers and among those who maintained social and physical distancing in the last month compared to their counterparts. Among the infected, 62·2% had more than three symptoms, 11·1% had one or two symptoms, and 26·0% were asymptomatic. The infection fatality rate was 0·17%, higher for males and advanced age groups. The ratio of estimated infections to reported cases was 22·2.InterpretationTo the best of our knowledge, the seroprevalence of SARS-CoV-2 estimated in this population-based survey was the highest and the closest to the herd immunity threshold reported to date. Our results suggest that the herd immunity threshold is not as low as 20%, but at least higher than or equal to around 40%. The infection fatality rate was one of the lowest reported so far, and the proportion of asymptomatic cases was low.

This article aims to analyze the association between sleep time and handgrip strength in adolescents belonging to the 1997/1998 São Luís Birth Cohort. This was a cross-sectional study nested in a birth cohort study. One thousand two hundred sixty-nine individuals (18 and 19 years) wore an Actigraph® GTX3+ accelerometer on their wrist 24 hr/day for 7 consecutive days. Handgrip strength was measured using a digital hand dynamometer. We used directed acyclic graphs (DAG) to identify confounding variables. This sample of adolescents was mostly composed of men, with brown skin color, economic class C, which did not work, did not consume alcohol, did not smoke, and never used drugs. The mean value of handgrip strength was 28.2 (±9.3) kgf, and the mean of sleep time was 6 (±1.0) hours per day. The crude analysis showed an association between sleep time and muscle strength. An increase of one hour of sleep reduced the handgrip strength by 1.95 kgf (95%CI:-2.51;-1.39). However, after adjustment for confounders, the association was not maintained (β:-0.07; 95%CI:-0.48;0.36). Sleep time is not associated with handgrip strength in adolescents in São Luís. Resumo O objetivo deste artigo é analisar a associação entre tempo de sono e força de preensão manual em adolescentes da Coorte de Nascimentos de São Luís 1997/1998. Estudo transversal aninhado a um estudo de coorte de nascimentos. Mil duzentos e sessenta e nove indivíduos (18 e 19 anos) usaram um acelerômetro Actigraph® GTX3 + em seu pulso 24 horas/dia por sete dias consecutivos. A força de preensão manual foi medida por meio de um dinamômetro digital de mão. Usou-se gráficos acíclicos direcionados (DAG) para identificar variáveis de confusão. A amostra de adolescentes foi composta em sua maioria por homens, de cor da pele parda, classe econômica C, que não trabalhava, não consumiam álcool, não fumavam e nunca usaram drogas. O valor médio da força de preensão manual foi de 28,2 (±9,3) kgf, e a média do tempo de sono foi de seis (±1,0) horas por dia. A análise bruta mostrou associação entre tempo de sono e força muscular. O aumento de uma hora de sono reduziu a força de preensão manual em 1,95 kgf (IC95%:-2,51;-1,39). No entanto, após o ajuste para fatores de confusão, a associação não foi mantida (β:-0,07; IC95%:-0,48;0,36). O tempo de sono não foi associado à força de preensão manual em adolescentes de São Luís.

This paper describes the history, objectives and methods used by the nine Brazilian cohorts of the RPS Brazilian Birth Cohorts Consortium (Ribeirão Preto, Pelotas and São Luís) Common thematic axes are identified and the objectives, baseline periods, follow-up stages and representativity of the population studied are presented. The Consortium includes three birth cohorts from Ribeirão Preto, São Paulo State (1978/1979, 1994 and 2010), four from Pelotas, Rio Grande do Sul State (1982, 1993, 2004 and 2015), and two from São Luís, Maranhão State (1997 and 2010). The cohorts cover three regions of Brazil, from three distinct states, with marked socioeconomic, cultural and infrastructure differences. The cohorts were started at birth, except for the most recent one in each municipality, where mothers were recruited during pregnancy. The instruments for data collection have been refined in order to approach different exposures during the early phases of life and their long-term influence on the health-disease process. The investigators of the nine cohorts carried out perinatal studies and later studied human capital, mental health, nutrition and precursor signs of noncommunicable diseases. A total of 17,636 liveborns were recruited in Ribeirão Preto, 19,669 in Pelotas, and 7,659 in São Luís. In the studies starting during pregnancy, 1,400 pregnant women were interviewed in Ribeirão Preto, 3,199 in Pelotas, and 1,447 in São Luís. Different strategies were employed to reduce losses to follow-up. This research network allows the analysis of the incidence of diseases and the establishment of possible causal relations that might explain the health outcomes of these populations in order to contribute to the development of governmental actions and health policies more consistent with reality.

This article eevaluates delivery and birth care practices in maternity facilities in Brazil's North and Northeast regions. We conducted a qualitative evaluation of 91 facilities in the North and 181 facilities in the Northeast. The data was collected using systematic observation by a team of 44 previously trained evaluators and recorded in a field diary. A thematic analysis of the collected data was performed, resulting in three core themes: challenges of collegial management; challenges for coping with obstetric violence; and the potential of the evaluation process for driving change. Advances were made in the implementation of good labor and childbirth care practices; however, some maternity facilities still reproduce hierarchical models without spaces for collegial management and accounts of obstetric violence were common. Health professionals used the presence of risk to justify the low level of adoption of good practices. However, the findings reveal progress towards the humanization of care. The results also show the potential of the evaluation process for driving change. Although progress has been made towards the adoption of the good practices recommended by the Stork Network Program both in the area of management and care delivery, many challenges remain in view of the dominance of a hierarchical management model associated with an interventionist approach to health care.O objetivo deste artigo é avaliar práticas de atenção ao parto e nascimento em maternidades do Norte e Nordeste brasileiros. Avaliação qualitativa realizada em 91 maternidades no Norte e 181 no Nordeste do Brasil. A técnica de pesquisa foi a observação sistematizada, realizada por 44 avaliadores previamente treinados e registrada em diário de campo. Foi realizada análise de conteúdo na modalidade temática. Os núcleos temáticos encontrados foram: Desafios da Gestão Colegiada; Desafios para o enfrentamento da Violência Obstétrica; e Potencial do processo avaliativo na indução de mudanças. Foram identificados avanços na implantação de boas práticas na gestão do cuidado e atenção à saúde, embora algumas maternidades ainda reproduzam um modelo hierárquico, sem espaços colegiados de gestão e com práticas de violência obstétrica. Situações de risco em gestantes justificaram menor adesão dos profissionais de saúde às boas práticas, ainda que ações em direção à humanização também tenham sido visibilizadas. Identificou-se a potência do processo avaliativo na indução de mudanças. Foram evidenciadas mudanças em direção às boas práticas preconizadas pela Rede Cegonha, tanto na gestão quanto na atenção, mas são muitos os desafios frente ao predomínio de um modelo de gestão hierárquico associado a um modelo de atenção com práticas intervencionistas.

This study aimed to evaluate the racial inequality on childbirth care at the Rede Cegonha (Stork Network) using obstetric good practice and interventions indicators. Racial inequality, measured by the total effect of ethnicity/skin color in the crude model, was seen in many indicators. After adjusting for mediators, such as age, schooling, parity, high-risk hospital, and geographic macro-regions, the persistent direct effect suggests racial discrimination against black women with lower partograph completion (PR 0.88; 95% CI 0.80-0.95). Black women stayed less in lithotomy (PR 0.93; 95% CI 0.89-0.98), performed less episiotomy (PR 0.81; 95% CI 0.68 - 0.96), and had less episiotomy suturing pain (PR 0.66; 95% CI 0.51 - 0.87) when compared to white women, suggesting more good practice applied to black women. However, according to the interventionist care model still adopted by many professionals, these practices are routine, and lower achievement in black women would be better interpreted as evidence of racial discrimination against these women. For other outcomes, the ethnicity/skin color effect disappeared after adjusting for mediators, suggesting mitigation or disappearance of the skin color effect in some practices/interventions in childbirth.O objetivo do presente estudo foi avaliar desigualdade racial na atenção ao parto e ao nascimento na Rede Cegonha utilizando indicadores de boas práticas e intervenções obstétricas. Desigualdade racial, mensurada pelo efeito total da raça/cor no modelo sem ajuste, foi detectada em muitos indicadores. A persistência do efeito direto, após ajuste para os mediadores idade, escolaridade, paridade, hospital de alto risco e região geográfica, sugere discriminação racial contra as pretas, que tiveram menos partograma preenchido (RP 0,88; IC 95% 0,80-0,95). Comparadas às brancas, as pretas ficaram menos em litotomia (RP 0,93; IC95% 0,89-0,98), realizaram menos episiotomia (RP 0,81; IC95% 0,68-0,96) e tiveram menos dor na sutura da episiotomia (RP 0,66; IC95% 0,51-0,87), sugerindo que boas práticas estariam sendo mais realizadas nas pretas. Entretanto, pelo modelo intervencionista de assistência, ainda adotado por muitos profissionais, essas práticas são de rotina e a menor realização delas nas pretas seria melhor interpretada como evidência de discriminação racial a essas mulheres. Para outros desfechos, o efeito da raça/cor desapareceu após o ajuste para mediadores, sugerindo atenuação ou desaparecimento do efeito da cor da pele em algumas práticas/intervenções na assistência ao parto e nascimento.

This article compares the findings of "Avaliação da Rede Cegonha" (ARC - Stork Network Assessment), an evaluative study on the Rede Cegonha (RC - Stork Network) program, with Nascer no Brasil (NB - Born in Brazil), a national survey on labor and birth, conducted in 2011-12, before the start implementation of RC. ARC was conducted in 2017, in 606 maternity hospitals involved in RC and NB included a sample with national representation of 266 hospitals. In the current analysis, we included the 136 SUS hospitals that participated in both studies, totaling 3,790 and 12,227 puerperal women. We perform comparisons of best practices and interventions in the management of labor and delivery using Pearson's chi-square test for independent samples. The prevalence of best practices was, on average, 150% higher in ARC than in NB, with a greater relative increase in less developed regions, for older, brown and black women and less educated. Regarding interventions, there was an average reduction of 30% between NB and ARC, with a greater relative reduction in less developed regions and less educated women. There was a significant improvement in the scenario of care for labor and childbirth, with a reduction in regional, educational and racial inequalities in access to appropriate technologies, suggesting that the RC intervention was effective.Este artigo compara os achados da Avaliação da Rede Cegonha (ARC), estudo avaliativo sobre o programa Rede Cegonha (RC), com o Nascer no Brasil (NB), inquérito nacional sobre parto e nascimento, realizado em 2011-12, antes do início da implementação da RC. A ARC foi conduzida em 2017, em 606 maternidades envolvidas na RC e o NB e empregou uma amostra com representatividade nacional de 266 hospitais. Na análise atual, incluímos os 136 hospitais do SUS que participaram de ambos os estudos, totalizando 3.790 e 12.227 puérperas, respectivamente. Realizamos as comparações de boas práticas e intervenções no manejo do trabalho de parto e de parto utilizando o teste qui-quadrado para amostras independentes. A prevalência das boas práticas foi, em média, 150% maior na ARC que no NB, com maior aumento relativo nas regiões menos desenvolvidas, para mulheres mais velhas, pardas e pretas e menos escolarizadas. Com relação às intervenções, houve redução média de 30% entre o NB e a ARC, com maior redução relativa nas regiões menos desenvolvidas e nas mulheres menos escolarizadas. Houve melhoria significativa no cenário da atenção ao trabalho de parto e parto, com diminuição de iniquidades regionais, de nível de instrução e raciais no acesso às tecnologias apropriadas, sugerindo que a intervenção da RC foi efetiva.

Objectives: To describe the medication profile used during pregnancy in a Brazilian capital. Methods: Descriptive cross-sectional study with data from BRISA study in São Luís, Maranhão. Participants were interviewed in hospitals and maternity hospitals after delivery and were asked about the use of medications during pregnancy. The drugs were classified according the Anatomical Therapeutic Chemical Classification and risk categories of the Food and Drug Administration. Results: 5,110 puerperal women were interviewed, of which 93.5% reported the use of at least one medication during pregnancy. The most frequent medications were: antianemic preparations (ferrous sulfate: 72.2%; iron and multivitamins: 4.9%, folic acid: 62.9% and associations with folic acid: 6.7%), vitamins (multivitamins and others minerals: 30.3%), analgesics (paracetamol: 12.3%), antibacterials for systemic use (cephalexin: 5.6%), antiemetics and anti-nauseating agents (scopolamine butylbromide: 5.4%) and antihypertensives (methyldopa): 3.6%). Among the drugs reported: 74.5% were from category A, 18.9% from category B, 5.5% from category C, 1.0% from category D and 0.1% from category X. Conclusions: Despite, the higher prevalence of medication use during pregnancy, most of which are considered safe in pregnancy. However, it is important that the use of drugs during pregnancy is monitored and guided by health professionals in order to ensure its rational use. Objetivos: Describir el perfil de medicación utilizada durante el embarazo en una capital brasileña. Métodos: Estudio descriptivo transversal con datos del estudio BRISA en São Luís, Maranhão. Las participantes fueron entrevistadas en hospitales y maternidades después del parto y se les preguntó sobre el uso de medicamentos durante el embarazo. Los medicamentos se clasificaron de acuerdo con la Clasificación Química Anatómica Terapéutica y las categorías de riesgo de la Administración de Alimentos y Medicamentos. Resultados: Se entrevistó a 5.110 puérperas, de las cuales el 93,5% refirió el uso de al menos un medicamento durante el embarazo. Los medicamentos más frecuentes fueron: preparados antianémicos (sulfato ferroso: 72,2%; hierro y multivitamínicos: 4,9%, ácido fólico: 62,9% y asociaciones con ácido fólico: 6,7%), vitaminas (multivitamínicos y otros minerales: 30,3%), analgésicos (paracetamol: 12,3%), antibacterianos de uso sistémico (cefalexina: 5,6%), antieméticos y antieméticos (butilbromuro de escopolamina: 5,4%) y antihipertensivos (metildopa): 3,6%). Entre los medicamentos reportados: 74,5% eran de la categoría A, 18,9% de la categoría B, 5,5% de la categoría C, 1,0% de la categoría D y 0,1% de la categoría X. Conclusiones: A pesar de la mayor prevalencia del uso de medicamentos durante el embarazo, la mayoría de los cuales se consideran seguros durante el embarazo. Sin embargo, es importante que el uso de medicamentos durante el embarazo sea monitoreado y guiado por profesionales de la salud para asegurar su uso racional. Objetivos: Descrever o perfil do uso de medicamentos na gestação em uma capital brasileira. Métodos: Estudo transversal descritivo com dados do estudo BRISA em São Luís, Maranhão. As participantes foram entrevistadas nos hospitais e maternidades após o parto, sendo questionadas sobre o uso de medicamentos na gestação. Os medicamentos foram classificados de acordo com a Anatomical Therapeutic Chemical Classification e categorias de risco da Food and Drug Administration. Resultados: Foram entrevistadas 5.110 puérperas, das quais 93,5% relataram o uso de pelo menos um medicamento na gestação. Os medicamentos mais frequentes foram: preparações antianêmicas (sulfato ferroso: 72,2%; ferro e multivitaminas: 4,9%, ácido fólico: 62,9% e associações com ácido fólico: 6,7%), vitaminas (multivitamínicos e outros minerais: 30,3%), analgésicos (paracetamol: 12,3%), antibacterianos de uso sistêmico (cefalexina: 5,6%), antieméticos e antinauseantes (butilbrometo de escopolamina: 5,4%) e anti-hipertensivos (metildopa: 3,6%). Dentre os medicamentos relatados: 74,5% foram da categoria A, 18,9% da categoria B, 5,5% da categoria C, 1,0% da categoria D e 0,1% da categoria X. Conclusões: Observou-se elevada prevalência de utilização de medicamentos na gestação, sendo a maioria de uso considerado seguro na gravidez. Porém, é importante que a utilização de fármacos na gestação seja monitorada e orientada por profissionais de saúde visando garantir o seu uso racional.

To estimate and assess pregnancy smoking trends since 1978, according to sociodemographic characteristics, in three Brazilian sites. We used cross-sectional data from the perinatal studies of nine birth cohorts, located in the southeast (Ribeirao Preto—1978/1979, 1994, and 2010), south (Pelotas—1982, 1993, 2004, and 2015), and northeast (Sao Luis—1997/1998 and 2010) regions of Brazil. We estimated the prevalence of pregnancy smoking at each time point according to age, education, and family income, in each cohort, and evaluated smoking trends. We analyzed data of 17,275 women in Ribeirao Preto, 19,819 in Pelotas, and 7753 in Sao Luis. Smoking decreased by 59% in Ribeirao Preto (p

The study aimed to estimate the prevalence of health indicators among adolescents in São Luís, Maranhão State, Brazil, in 2016. The analysis included sociodemographic conditions, life habits, body composition, sleep quality, physical activity, cognitive performance, and suicide risk in 2,515 adolescents 18 to 19 years of age. The adolescents belonged to the 1997/1998 birth cohort or were included retrospectively using the SINASC (Brazilian Information System on Live Births) database. The adolescents were mainly from economic class C (50.1%), 69.5% were in school, 40.3% were working, and 25.2% were neither studying nor working; 60.3% had been robbed, and 48.7% had parents who were separated or divorced; 19.4% showed harmful or excessive alcohol consumption or probable addiction, 19.1% had used or were using illicit drugs, 53.7% reported poor sleep quality, 40.8% reported frequent headaches, 34.3% reported more than five hours of daily screen time, and 4.1% showed high suicide risk. Prevalence of high blood pressure was 12%, and 6% were obese. Girls were more physically inactive (80.7%) and showed greater percentage of high (15.8%) and very high body fat (21.5%), while boys showed greater prevalence of high blood pressure (21.2%) and lower prevalence of physical inactivity (40.9%). High prevalence rates of health risk factors increase the adolescents' vulnerability, exposing these individuals earlier to factors leading to diseases and other health problems.

In 2015, there was an epidemic of microcephaly in Brazil that was associated with infection by the Zika virus. The condition of these children obliged the parents to embark on a quest in search of treatment. The scope of this study was to establish the therapeutic itinerary pursued in healthcare sectors by parents and/or caregivers of children with microcephaly due to the Zika virus. It involved qualitative research, conducted at a Center of Reference on Neurodevelopment between April 2017 and February 2018, with parents and/or caregivers of children with microcephaly caused by the Zika virus. The sample complied with the criteria of saturation. Twenty semi-structured interviews were conducted, recorded, and transcribed, and content analysis was applied. The results revealed disorientation and uncertainties in the search for care in the health sector. The most sought-after sector was the professional sector, followed by the informal sector. The information conveyed in the media and social networks, which constitute part of the informal sector, helped to clarify the significance of microcephaly and the Zika virus and assisted in the search for treatment. Care in the healthcare network was marked by difficulties and, faced with a new and emergency situation, the route between diagnosis and treatment was arduous.Em 2015, no Brasil, houve uma epidemia de microcefalia que foi associada à infecção pelo vírus Zika. A condição destas crianças impulsionou os pais a percorrerem um caminho em busca por tratamento. O objetivo deste estudo foi conhecer o itinerário terapêutico percorrido por pais e/ou cuidadores de crianças com microcefalia pelo vírus Zika nos setores de atenção à saúde. Pesquisa de abordagem qualitativa, realizada em um Centro de Referência em Neurodesenvolvimento, no período de abril de 2017 a fevereiro de 2018, com pais e/ou cuidadores de crianças com microcefalia pelo vírus Zika. A amostra obedeceu aos critérios de saturação de sentidos. Foram feitas 20 entrevistas semiestruturadas, gravadas e transcritas. Realizou-se análise de conteúdo, na modalidade temática. Os resultados demostraram desorientação e incertezas na busca pelo cuidado nos setores de saúde. O setor mais procurado foi o profissional, seguido pelo informal e popular. As informações veiculadas na mídia e redes sociais, que fazem parte do setor informal, contribuíram para esclarecer o significado da microcefalia e vírus Zika e auxiliou na busca por tratamento. O cuidado na rede de Atenção à Saúde foi marcado pela peregrinação. Diante de uma situação nova e emergencial, o caminho percorrido, entre o diagnóstico e o tratamento, foi árduo.

OBJETIVOS: Estimar a prevalência e fatores associados à hesitação ao uso da vacina contra o vírus SARS-CoV-2 no Maranhão, Brasil. MÉTODOS: Estudo transversal de base populacional realizado de 19 a 30 de outubro de 2020. As estimativas consideraram agrupamento, estratificação e não resposta. A seleção da amostra foi realizada em três estágios (estrato, setores censitários e domicílio). Após análise sistemática, em cada estrato foram selecionados trinta setores, totalizando 150 setores, sendo o número de domicílios em cada setor fixado em 34, totalizando 5.100 domicílios e um indivíduo por domicílio (residente pelo menos há seis meses e com um ano de idade ou mais) selecionado por amostra aleatória simples. A intenção de ser vacinado foi questionada aos participantes. Foi realizada análise descritiva (frequências ponderadas) e teste do qui-quadrado de Pearson para verificar associação univariada entre as variáveis independentes e o desfecho (p < 0,05). Realizou-se análise multivariada robusta utilizando-se modelagem hierarquizada em três níveis. RESULTADOS: Foram entrevistados 4.630 indivíduos. A prevalência de hesitação vacinal foi de 17,5% (IC95% 16,1–19,1%). Após ajuste final do modelo, a hesitação vacinal foi estatisticamente maior entre moradores das cidades de Imperatriz (24,0%; RP = 1,48; IC95% 1,09–2,02) e de munícipios da Grande Ilha de São Luís (20,7%; RP = 1,34; IC95% 1,02–1,76), pessoas do sexo feminino (19,8%; RP = 1,44; IC95% 1,20–1,75), idosos (22,8%; RP = 1,79; IC95% 1,30–2,46), pertencentes às religiões de denominação evangélica (24,1%; RP = 1,49; IC95% 1,24–1,79) e entre aqueles sem relato de sintomas (18,6%; RP = 1,24; IC95% 1,02–1,51). Outras características socioeconômicas e demográficas, assim como variáveis relacionadas ao mercado de trabalho, comportamentos e condições de saúde dos entrevistados, não tiveram diferença estatística. CONCLUSÃO: A prevalência de hesitação vacinal no Maranhão e sua associação com fatores individuais, contextuais e clínicos revelam os grupos e contextos mais resistentes e que devem merecer atenção especial das estratégias públicas para garantir a ampla vacinação.

We report the early growth and neurologic findings of 48 infants in Brazil diagnosed with probable congenital Zika virus syndrome and followed to age 1-8 months. Most of these infants had microcephaly (86.7%) and craniofacial disproportion (95.8%). The clinical pattern included poor head growth with increasingly negative z-scores, pyramidal/extrapyramidal symptoms, and epilepsy.

Objective The aim of this study was to investigate the association between percent contribution of ultra-processed foods to total dietary energy intake and measurements of body composition obtained using high-validity methods. Methods This was a cross-sectional study with 1525 adolescents 18 to 19 y of age from the second follow-up of the 1997/98 Sao Luis birth cohort, Brazil. To evaluate nutritional status and body composition, the body mass index (BMI)-for-age was used, along with waist circumference, total and android body fat percentage, muscle mass, and the lean mass index (LMI). Food consumption was evaluated by a food frequency questionnaire. Food items were grouped according to the level of processing as per the NOVA classification. Through semi-structured questionnaires, sociodemographic and lifestyle data were abstracted. Adjusted linear regression models were used to evaluate the associations between consumption of ultra-processed foods and body composition measurements. Results Total average energy consumption was 2919.7 kcal, with 58% (1634.9 kcal) derived from natural or minimally processed foods and 37% (1136.5 kcal) from ultra-processed products. In the adjusted analyses, BMI, muscle mass, and LMI were inversely associated with consumption of ultra-processed foods. A 1% increase in the percent contribution of ultra-processed items to total dietary energy intake was associated with a 0.04 kg decrease in muscle mass (β = –0.04; 95% confidence interval [CI], –0.06 to –0.02; P Conclusion The contribution of ultra-processed foods to total dietary energy intake of Brazilian adolescents was associated with body composition, especially with decreasing lean body mass.

The short duration of viremia, low blood viral load, inaccessibility to timely specific diagnostic tests, and cross-reactions with other flaviviruses have hindered laboratory confirmation of Congenital Zika Syndrome (CZS). This study analyzes the positivity of the plaque reduction neutralization test (PRNT) in children with clinical or imaging characteristics of CZS and its association with laboratory, clinical, and imaging characteristics. The 94 clinical cases of CZS submitted to the ZIKV PRNT90 test were followed from 2016 to 2018. The mean age of children at PRNT90 collection was 22 &plusmn, 6 months Standard Deviation. The ZIKV PRNT90 was positive (titer &ge, 10) in 40 (42.5%) children. ZIKV PRNT90 positivity was associated with severe microcephaly in newborns (p = 0.016), lower head circumference z-score at birth (p = 0.043) and 24 months of age (p = 0.031), and severe reduction of the cerebral parenchyma volume (p = 0.021), expressing greater disease severity. Negative PRNT90 in children with characteristic signs of CZS may be due to false-negative results, indicating that the diagnosis of CZS should be primarily syndromic.

BackgroundEconomic recessions carry an impact on population health and access to care; less is known on how health systems adapt to the conditions brought by a downturn. This particularly matters now that the COVID-19 epidemic is putting health systems under stress. Brazil is one of the world's most affected countries, and its health system was already experiencing the aftermath of the 2015 recession.MethodsBetween 2018 and 2019 we conducted 46 semi-structured interviews with health practitioners, managers and policy-makers to explore the impact of the 2015 recession on public and private providers in prosperous (São Paulo) and impoverished (Maranhão) states in Brazil. Thematic analysis was employed to identify drivers and consequences of system adaptation and coping strategies. Nvivo software was used to aid data collection and analysis. We followed the Standards for Reporting Qualitative Research to provide an account of the findings.ResultsWe found the concept of 'health sector crisis' to be politically charged among healthcare providers in São Paulo and Maranhão. Contrary to expectations, the public sector was reported to have found ways to compensate for diminishing federal funding, having outsourced services and adopted flexible-if insecure-working arrangements. Following a drop in employment and health plans, private health insurance companies have streamlined their offer, at times at the expenses of coverage. Low-cost walk-in clinics were hit hard by the recession, but were also credited for having moved to cater for higher-income customers in Maranhão.ConclusionsThe 'plates' of a health system may shift and adjust in unexpected ways in response to recessions, and some of these changes might outlast the crisis. As low-income countries enter post-COVID economic recessions, it will be important to monitor the adjustments taking place in health systems, to ensure that past gains in access to care and job security are not eroded.

Objetivo:Analisar a associação entre o declínio cognitivo e a qualidade de vida de idosos hipertensos.Métodos:Pesquisa de abordagem quantitativa com delineamento analítico transversal, com 125 idosos hipertensos, de ambos os sexos, atendidos no Programa HIPERDIA, de São Luís-MA. Para a avaliação do declínio cognitivo, aplicou-se o Miniexame do Estado Mental (MEEM) e para avaliar a qualidade de vida, o Medical Outcomes Study 36 - Short-Form Health Survey (SF-36). A normalidade dos dados foi testada por meio do teste de Shapiro-Wilk, utilizando-se ainda o teste de Mann Whitney (qualidade de vida). Para testar a associação entre declínio cognitivo e qualidade de vida, usou-se o coeficiente de Spearman.Resultados:A prevalência de declínio cognitivo foi de 20,80%, com predominância em idosos com baixa escolaridade (45,83%). Idosos hipertensos com declínio cognitivo apresentaram pior qualidade de vida, comparados aos idosos hipertensos sem declínio cognitivo. Houve associação positiva da função cognitiva com a qualidade de vida nos domínios: capacidade funcional (r=0,222; p=0,01), dor (r=0,1871; p=0,04) e aspectos emocionais (r=0,3136; p=0,0005).Conclusão:Os resultados encontrados neste estudo sugerem que o declínio cognitivo afeta diretamente a qualidade de vida do idoso hipertenso, na medida em que limita a capacidade de realização de atividades do cotidiano, principalmente se associado a quadros dolorosos e alterações emocionais. Objective:To evaluate the association between cognitive decline and quality of life in hypertensive elderly persons.Methods:A quantitative, cross-sectional, analytical study involving 125 hypertensive elderly individuals of both genders attending the HIPERDIA Program in São Luís, in the state of Maranhao, was performed. The Mini Mental State Exam (MMSE) was used to evaluate cognitive decline and quality of life was assessed using the Medical Outcomes Study 36 Short-Form Health Survey (SF-36). The normality of the data was verified by the Shapiro-Wilk test. The Mann-Whitney test was also applied (quality of life). The association between cognitive decline and quality of life was evaluated using Spearman's coefficient.Results:The prevalence of cognitive decline was 20.8% and there was a predominance of elderly persons with a low educational level (45.83%). Hypertensive elderly individuals with cognitive decline had a poorer quality of life than those without cognitive decline. A positive association between cognitive function and quality of life was observed for the following domains: functional capacity (r=0.222; p=0.01), pain (r=0.1871; p=0.04), and emotional aspects (r=0.3136; p=0.0005).Conclusion:The results of this study suggest that cognitive decline directly affects the quality of life of the elderly by limiting the capacity to perform activities of daily living, especially if associated with painful medical conditions and emotional disturbances.

The objectives of this study were to estimate the involuntary pilgrimage by women in labor in search of childbirth care and to identify factors associated with this endeavor in two Brazilian cities. This was a cross-sectional study nested in the BRISA birth cohort, whose sample consisted of 10,475 women admitted to the selected maternity hospitals for delivery in São Luís (Maranhão State) and Ribeirão Preto (São Paulo State). Interviews were held with questionnaires that contained sociodemographic and obstetric variables. Hierarchical modeling was used, and relative risk was calculated with Poisson regression. Involuntary pilgrimage during labor was more frequent in São Luís (35.8%) than in Ribeirão Preto (5.8%). In São Luís, factors associated with pilgrimage were: first pregnancy (RR = 1.19; 95%CI: 1.08-1.31) and schooling less than 12 complete years. However, age 35 years or older (RR = 0.65; 95%CI: 0.54-0.84) was associated with less pilgrimage. In Ribeirão Preto, such trekking for obstetric care was more frequent in women with high-risk pregnancies (RR = 2.45; 95%CI: 1.81-3.32) and those with gestational age less than 37 weeks (RR = 1.93; 95%CI: 1.50-2.50). Meanwhile, delivery with gestational age equal to or greater than 42 weeks was associated with less pilgrimage (RR = 0.57; 95%CI: 0.33-0.98). In both cities, poor women had to trek more in search of childbirth care and had no guarantee of care, even for those who had received prenatal care. The study revealed the lack of guarantee of universal and equitable access and highlighted the unequal access to childbirth care between Brazil's major geographic regions.O objetivo deste trabalho foi estimar a peregrinação de gestantes no momento do parto e identificar os fatores associados a essa peregrinação em duas cidades brasileiras. Estudo seccional, aninhado à coorte de nascimento BRISA, cuja amostra foi composta por 10.475 gestantes admitidas nas maternidades selecionadas por ocasião do parto em São Luís (Maranhão) e Ribeirão Preto (São Paulo). Entrevistas foram realizadas utilizando-se questionários que continham variáveis sociodemográficas e relacionadas ao parto. Utilizou-se modelagem hierarquizada, e calculou-se o risco relativo utilizando regressão de Poisson. A peregrinação foi mais frequente em São Luís (35,8%) que em Ribeirão Preto (5,8%). Em São Luís, foram fatores associados à maior peregrinação: ser primípara (RR = 1,19; IC95%: 1,08-1,31) e ter escolaridade menor que 12 ou mais anos de estudo. Entretanto, ter 35 anos ou mais (RR = 0,65; IC95%: 0,54-0,84) foi fator associado à menor peregrinação. Em Ribeirão Preto, peregrinaram com maior frequência as gestantes cujos partos foram de alto risco (RR = 2,45; IC95%: 1,81-3,32) e com idade gestacional inferior a 37 semanas (RR = 1,93; IC95%: 1,50-2,50). No entanto, partos com idade gestacional igual ou acima de 42 semanas foi um fator associado à menor peregrinação (RR = 0,57; IC95%: 0,33-0,98). Nas duas cidades, gestantes pobres peregrinaram com maior frequência, e sem garantia de que seriam atendidas, mesmo dentre as que realizaram o pré-natal. O estudo evidenciou ausência da garantia de acesso universal e equânime e reafirmou a desigualdade de acesso à assistência ao parto entre as regiões brasileiras.El objetivo de este trabajo fue estimar los desplazamientos largos de gestantes en el momento del parto e identificar los factores asociados a estos desplazamientos en dos ciudades brasileñas. Se trata de una investigación seccional, encajada en la cohorte de nacimiento BRISA, cuya muestra estuvo compuesta por 10.475 gestantes, admitidas en las maternidades seleccionadas para dar a luz en São Luís (Maranhão) y Ribeirão Preto (São Paulo). Las entrevistas se realizaron utilizando cuestionarios que contenían variables sociodemográficas y relacionadas con el parto. Se utilizó un modelado jerarquizado, y se calculó el riesgo relativo utilizando la regresión de Poisson. Los desplazamientos fueron más frecuentes en São Luís (35,8%) que en Ribeirão Preto (5,8%). En São Luís, los factores asociados a mayores desplazamientos fueron: ser primípara (RR = 1,19; IC95%: 1,08-1,31) y contar con una escolaridad menor a 12 o más años de estudio. Sin embargo, tener 35 años o más (RR = 0,65; IC95%: 0,54-0,84) fue un factor asociado a menores desplazamientos. En Ribeirão Preto, se desplazaron con mayor frecuencia las gestantes cuyos partos fueron de alto riesgo (RR = 2,45; IC95%: 1,81-3,32) y con una edad gestacional inferior a 37 semanas (RR = 1,93; IC95%: 1,50-2,50). Sin embargo, los partos con una edad gestacional igual o por encima de las 42 semanas fue un factor asociado a un menor desplazamiento (RR = 0,57; IC95%: 0,33-0,98). En las dos ciudades, las gestantes pobres se desplazaron con mayor frecuencia, y sin garantía de que serían atendidas, incluso entre quienes realizaron seguimiento prenatal. El estudio evidenció la inexistencia de garantías de acceso universal y ecuánime a la salud y reafirmó la desigualdad de acceso en la asistencia al parto entre regiones brasileñas.

OBJECTIVES: To estimate the baseline prevalence and risk factors for microcephaly at birth before the Zika virus epidemic in 2 Brazilian cities. METHODS: We used population-based data from the Brazilian Ribeirão Preto (RP) and São Luís (SL) birth cohort studies of 2010 that included hospital deliveries by resident mothers. The final sample was 7376 live births in RP and 4220 in SL. Gestational age was based on the date of the mother’s last normal menstrual period or obstetric ultrasonography, if available. Microcephaly at birth was classified according to the criteria of the International Fetal and Newborn Growth Consortium for the 21st Century and the Brazilian Ministry of Health. Risk factors for microcephaly, proportionate and disproportionate microcephaly, and severe microcephaly were estimated in a hierarchized logistic regression model. RESULTS: According to the International Fetal and Newborn Growth Consortium for the 21st Century definition, the prevalence of microcephaly (>2 SDs below the mean for gestational age and sex) was higher in SL (3.5%) than in RP (2.5%). The prevalence of severe microcephaly (>3 SDs below the mean) was higher in SL (0.7%) than in RP (0.5%). Low maternal schooling, living in consensual union or without a companion, maternal smoking during pregnancy, primiparity, vaginal delivery, and intrauterine growth restriction were consistently associated with microcephaly. The number of cases of microcephaly is grossly underestimated, with an underreporting rate of ∼90%. CONCLUSIONS: The prevalence of severe microcephaly was much higher than expected in both cities. Our findings suggest that microcephaly was endemic in both municipalities before the circulation of the Zika virus.

Health services play a crucial role in reaching the 90-90-90 target of controlling the HIV epidemic. This study evaluates the organization of Brazilian health services in improving, monitoring, and retention in HIV care and adherence support. Percentage variation (PV) was used to compare the responses by services to an evaluation questionnaire on organizational quality (Qualiaids) in 2007 and 2010. The study analyzed the 419 services that completed the questionnaire in 2007 (83.1% of respondents) and 2010 (63.6%). Management actions of retention and support although increased in the period, but remained at low rates, for example: systematic meetings for case discussion (32.7% in 2010; PV = 19.8%) and recording of missed medical appointments (35.3%; PV = 36.8%). Patient care actions related to adherence to ART remained largely exclusive to the attending physician. The supply of funds and resources from the Federal Government (medicines and specific HIV tests) remained high for the vast majority of the services (~90%). It will not be possible to achieve a significant decrease in HIV transmission as long as retention in treatment is not a priority in all the health services.O papel dos serviços de saúde é crucial para o alcance da meta 90-90-90 de controle da epidemia do HIV. O estudo avalia a organização dos serviços brasileiros nas ações de promoção, monitoramento e suporte à retenção no seguimento e apoio ao tratamento. Foram comparadas, por meio de variação percentual (VP), as respostas dos serviços a um questionário de avaliação da qualidade organizacional (Qualiaids) em 2007 e em 2010. Analisou-se os 419 serviços que responderam ao questionário em 2007 (83,1% dos respondentes) e 2010 (63,6%). Ações gerenciais relacionadas à retenção e apoio, embora incrementadas no período, permaneceram com baixa frequência, tais como: reuniões sistemáticas para discussão de casos; (32,7% em 2010; VP = 19,8%), registro de faltas em consulta médica (35,3%; VP = 36,8%). Ações assistenciais relacionadas à adesão ao tratamento medicamentoso permanecem majoritariamente exclusivas do médico. O aporte de recursos de provisão federal - medicamentos e exames específicos para HIV - manteve-se alto para a grande maioria dos serviços (~90%). Não se alcançará decréscimo significativo da transmissão do HIV enquanto a permanência no tratamento não for prioridade de todos os serviços de assistência.El papel de los servicios de salud es crucial para el alcance de la meta 90-90-90 de control de la epidemia de VIH. El estudio evalúa la organización de los servicios brasileños en las acciones de promoción, monitoreo y apoyo al mantenimiento del seguimiento y tratamiento. Se compararon, mediante la variación porcentual (VP), las respuestas de los servicios a un cuestionario de evaluación de la calidad organizativa (Qualiaids) en 2007 y en 2010. Se analizaron los 419 servicios que respondieron al cuestionario en 2007 (83,1% de los participantes) y 2010 (63,6%). Las acciones de gerencia, relacionadas con el mantenimiento y apoyo, aunque se incrementaron durante el período, permanecieron con baja frecuencia, tales como: reuniones sistemáticas para discusión de casos; (32,7% en 2010; VP = 19,8%), registro de faltas en consulta médica (35,3%; VP = 36,8%). Las acciones asistenciales relacionadas con la adhesión al tratamiento farmacológico continúan siendo mayoritariamente exclusivas del médico. La aportación de recursos de provisión federal -medicamentos y exámenes específicos para VIH- se mantuvo alta para la gran mayoría de los servicios (~90%). No se alcanzará un decremento significativo en la transmisión del VIH, mientras la permanencia en el tratamiento no sea una prioridad de todos los servicios de asistencia.

No Brasil, são escassas as pesquisas sobre a qualidade da atenção ao aborto inseguro. O presente artigo visa a apresentar a primeira etapa da construção de instrumento para estudo sobre a assistência hospitalar prestada pelo Sistema Único de Saúde em três cidades. Foram definidas quatro dimensões essenciais da atenção – acolhimento e orientação, qualidade técnica do cuidado, continuidade da atenção, insumos/ambiente físico – e respectivos critérios. Procedeu-se à adaptação transcultural de conjunto de itens propostos pela Organização Mundial da Saúde. Para dar conta de dimensões e critérios não contemplados pelo conjunto original de perguntas, optou-se por adaptar questões de outros estudos e adicionar outras elaboradas pela própria equipe. O questionário foi pré-testado em 52 usuárias, nas três cidades, para avaliar a aceitação e compreensão, o tempo de aplicação e ajustes finais. O instrumento totalizou 55 itens, organizados segundo os momentos assistenciais, cujo uso mais amplo depende de avaliações psicométricas em desenvolvimento e que se seguirão em outros artigos.

Breastfeeding plays an important role in child health. However, there are doubts about its influence on malocclusions. Systematic reviews have yielded contradictory results. Research aim: This study aimed to investigate whether the type and duration of breastfeeding are associated with malocclusions in primary teething.The review strategy included several electronic databases, lists of references, reviews, dissertation and thesis websites, experts, and other relevant documents. Published and unpublished observational studies ( N = 42) were reviewed using the Participants (children), Interventions (breastfeeding), Comparisons (bottle feeding), Outcomes (malocclusion), and Study design (observational) strategy, without restrictions on language or locale. Information about the authors, publication year, country of study, setting, study design, sample size, age, type and duration of exclusive and mixed breastfeeding, and malocclusions was recorded by two blinded evaluators. Quantitative meta-analysis ( N = 30) of the studies with available data was performed.Breastfeeding was a protective factor against malocclusions. The odds of association increased with breastfeeding duration. Irrespective of duration, breastfeeding had a protective association with open bite. For those who were breastfed for up to 6 months, breastfeeding protected against overjet, open bite, posterior crossbite, and crowding. Breastfeeding for 12 months or longer was associated with lower odds of overjet, open bite, and posterior crossbite. Breastfeeding exclusively for 6 months was also a protective factor against malocclusions. However, studies on this subject presented low quality, statistical heterogeneity, and only unadjusted measures of association in most of the cases.Breastfeeding beneficially affects primary occlusion when practiced for at least 6 months.

This study analyzed the effects of gestational weight gain and breastfeeding on postpartum weight retention. The study followed 2,607 women from the BRISA cohort. The variables were age, socioeconomic status, parity, pre-gestational body mass index, gestational weight gain, duration of maternal breastfeeding, length of postpartum follow-up, and postpartum weight gain. Structural equation modeling was used to evaluate the total, direct, and indirect effects of the explanatory variables on postpartum weight retention. An increase of one standard deviation in gestational weight gain corresponded to a significant increase of 0.49 standard deviations in postpartum weight retention (p0.001). An increase of one standard deviation in duration of breastfeeding corresponded to mean decrease of 0.10 standard deviations in postpartum weight retention (p0.001). Independently of pre-gestational BMI, gestational weight gain is a risk factor and duration of breastfeeding is a protective factor against postpartum weight retention.

Resumo O artigo objetiva analisar a prevalência e fatores associados ao uso de drogas ilícitas na gestação. Estudo transversal, aninhado à coorte pré-natal do estudo de coorte BRISA. Utilizou-se medidas de frequência e modelo de regressão logística múltipla hierarquizada. A prevalência estimada foi de 1,45% para o uso de drogas ilícitas, 22,32% para o uso de bebidas alcóolicas e 4,22% para o de cigarro. A população mostrou-se jovem, de 20-34 anos de idade (81%), com escolaridade de 9-11 anos de estudos (75,55%), com mais da metade das mulheres fora da população economicamente ativa (52,18%) e na classe econômica “C” (67,61%). As gestantes apresentaram nível de estresse elevado (24,46%), sintomas de ansiedade de moderada a intensa (40,84%) e sintomas depressivos graves (28,8%). Aproximadamente metade (49,72%) das gestantes relatou ter sofrido algum tipo de violência, tendo a maioria ampla rede (72,77%) e baixo apoio social (65,21%). Uso de drogas lícitas, níveis altos de estresse e monoparentalidade foram os fatores independentemente associados ao uso de drogas ilícitas na gestação.

Se investigo la asociacion entre actividad fisica durante el segundo trimestre gestacional y los desenlaces perinatales adversos: bajo peso al nacer (BPN), nacimiento pretermino (NPT) y restriccion de crecimiento intrauterino (RCIU). Se utilizo una muestra de la cohorte BRISA, Sao Luis, Maranhao, Brasil, que incluyo mujeres con un embarazo unico, edad gestacional de 22 a 25 semanas, confirmada por ultrasonografia obstetrica realizada con < 20 semanas, reentrevistadas en las primeras 24 horas tras el parto (n = 1.380). El nivel de actividad fisica fue medido por el Cuestionario Internacional de Actividad Fisica (IPAQ), version corta, y categorizado en alto, moderado y bajo. El grafo aciclico dirigido (DAG) se utilizo para identificar un ajuste minimo para el control de confusores. Un nivel alto de actividad fisica no se asocio al BPN (RR = 0,94; IC95%: 0,54-1,63), NPT (RR = 0,86; IC95%: 0,48-1,54) o RCIU (RR = 0,80; IC95%: 0,55-1,15). Los resultados fortalecen la hipotesis de que la practica de actividad fisica en la gestacion no parece resultar en desenlaces adversos al nacimiento.

OBJECTIVE: To obtain population estimates and profile risk factors for infant mortality in two birth cohorts and compare them among cities of different regions in Brazil. METHODS: In Ribeirão Preto, southeast Brazil, infant mortality was determined in a third of hospital live births (2,846 singleton deliveries) in 1994. In São Luís, northeast Brazil, data were obtained using systematic sampling of births stratified by maternity unit (2,443 singleton deliveries) in 1997-1998. Mothers answered standardized questionnaires shortly after delivery and information on infant deaths was retrieved from hospitals, registries and the States Health Secretarys' Office. The relative risk (RR) was estimated by Poisson regression. RESULTS: In São Luís, the infant mortality rate was 26.6/1,000 live births, the neonatal mortality rate was 18.4/1,000 and the post-neonatal mortality rate was 8.2/1,000, all higher than those observed in Ribeirão Preto (16.9, 10.9 and 6.0 per 1,000, respectively). Adjusted analysis revealed that previous stillbirths (RR=3.67 vs 4.13) and maternal age

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:56:57Z No. of bitstreams: 1 S0102-311X2004000800024.pdf: 90040 bytes, checksum: 9a6e5e6046d064813345248ae675b514 (MD5) Made available in DSpace on 2013-08-22T18:56:57Z (GMT). No. of bitstreams: 1 S0102-311X2004000800024.pdf: 90040 bytes, checksum: 9a6e5e6046d064813345248ae675b514 (MD5) Previous issue date: 2004-01-01 Made available in DSpace on 2013-09-30T19:51:16Z (GMT). No. of bitstreams: 2 S0102-311X2004000800024.pdf: 90040 bytes, checksum: 9a6e5e6046d064813345248ae675b514 (MD5) S0102-311X2004000800024.pdf.txt: 58251 bytes, checksum: 529de7f69fde022e53a81735a9d6cb77 (MD5) Previous issue date: 2004-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:13:19Z No. of bitstreams: 2 S0102-311X2004000800024.pdf: 90040 bytes, checksum: 9a6e5e6046d064813345248ae675b514 (MD5) S0102-311X2004000800024.pdf.txt: 58251 bytes, checksum: 529de7f69fde022e53a81735a9d6cb77 (MD5) Made available in DSpace on 2014-05-20T15:13:19Z (GMT). No. of bitstreams: 2 S0102-311X2004000800024.pdf: 90040 bytes, checksum: 9a6e5e6046d064813345248ae675b514 (MD5) S0102-311X2004000800024.pdf.txt: 58251 bytes, checksum: 529de7f69fde022e53a81735a9d6cb77 (MD5) Previous issue date: 2004-01-01 O artigo mostra o desenvolvimento de uma pesquisa que objetivou avaliar a qualidade da assistência ambulatorial do Programa Brasileiro de DST/ AIDS. A investigação, realizada entre 2001-2003, envolveu três projetos: uma análise do padrão tecnológico da assistência realizada em cinco serviços, uma avaliação qualitativa em 27 serviços e, finalmente, uma avaliação estruturada de 322 serviços de sete estados brasileiros. Mediante a descrição de todas as etapas dos projetos, as autoras discutem questões teóricas e metodológicas envolvidas na avaliação da assistência em programas de saúde. Discutem ainda algumas questões relacionadas à aplicabilidade e ao impacto das avaliações em serviços de saúde. This article discusses a study focused on quality care in health services under the Brazilian AIDS Program. Research in 2001-2003 involved three different projects: an in-depth analysis of the predominant health care pattern in five services, a qualitative evaluation of 27 services, and a structured evaluation of 322 services from seven Brazilian states. Through a description of the projects' stages, the authors discuss issues on theoretical and methodological approaches to evaluation of care in health programs. The discussion also focuses on key problems with the applicability and impact of health services evaluation. Universidade de São Paulo Faculdade de Medicina Universidade Estadual Paulista Faculdade de Medicina de Botucatu Universidade Estadual de Londrina (UEL) Universidade Federal do Maranhão Universidade Estadual Paulista Faculdade de Medicina de Botucatu

The association between young maternal age and preterm birth (PTB) remains controversial. In some studies the association disappeared after controlling for socio-economic and reproductive factors, thus indicating that social disadvantage rather than biological factors may be the explanation. However, in other studies the association persisted after adjustment. The relation between young maternal age and PTB was studied in a city located in Brazil, an underdeveloped country, where the prevalence of teenage pregnancy was high, 29%. A systematic sampling of 2541 hospital births, stratified by hospital, was performed in Sao Luis, Northeast Brazil, from March 1997 to February 1998. The risks of PTB for infants born to two groups of young mothers (

The objective of this study was to analyze changes in perinatal health in two birth cohorts started in 1997/1998 and 2010, respectively, in São Luís, Maranhão State, Brazil. A total of 2,493 live born infants were included in 1997/1998 and 5,166 in 2010. Low birth weight (LBW) rate did not change (8.5% in 1997/1998 and 8.6% in 2010). Preterm birth (PTB) rate also remained stable (13.2% in 1997/1998 and 13% in 2010). Teenage deliveries and births to single mothers decreased. Maternal schooling and prenatal care coverage increased. Intrauterine growth restriction (IUGR) decreased from 13.3% to 10.6% (p < 0.001). The perinatal mortality rate decreased from 36.6 to 20.7 per 1,000 (p < 0.001) and the infant mortality rate (IMR) dropped from 28.5 to 12.8 per 1,000 (p < 0.001). The cesarean rate increased from 34.1% to 47.5% (p < 0.001). In conclusion, despite favorable changes in socio-demographic, behavioral, and health service factors and decreasing rates of IUGR and perinatal and infant mortality, LBW and PTB remained stable, while the cesarean rate increased. O objetivo deste estudo foi analisar as mudanças na saúde perinatal em duas coortes de nascimento realizadas em 1997/1998 e 2010, em São Luís, Maranhão, Brasil. Um total de 2.493 nascidos vivos foi incluído em 1997/1998 e 5.166 em 2010. A taxa de baixo peso ao nascer (BPN) não se modificou (8,5% em 1997/1998 e 8,6% em 2010). A taxa de nascimento pré-termo (NPT) também permaneceu estável (13,2% em 1997/1998 e 13% em 2010). Nascimentos em adolescentes e em mulheres sem companheiro decresceram. A escolaridade materna e a cobertura do pré-natal aumentaram. A taxa de restrição de crescimento intrauterino (RCIU) diminuiu de 13,3% para 10,6% (p < 0,001). A taxa de mortalidade perinatal foi reduzida de 36,6 para 20,7 por mil (p < 0,001) e a taxa de mortalidade infantil diminuiu de 28,5 para 12,8 por mil (p < 0,001). A taxa de cesárea (TC) aumentou de 34,1% para 47,5% (p < 0,001). Apesar das mudanças favoráveis nas variáveis sociodemográficas, comportamentais e de serviços de saúde e da redução nas taxas de RCIU, mortalidade perinatal e infantil, as taxas de BPN e NPT permaneceram estáveis, enquanto a TC aumentou. El objetivo de este estudio fue analizar los cambios de la salud perinatal en dos cohortes de nacimiento realizadas en 1997/1998 y 2010 en São Luís, Maranhão, Brasil. Un total de 2.493 niños nacidos vivos fueron incluidos en 1997/1998 y 5.166 en 2010. La tasa de bajo peso al nacer (BPN) no cambió (8,5% y 8,6%). La tasa del nacimiento prematuro (TNP) también se mantuvo estable (13,2% y 13%). Los nacimientos entre adolescentes y madres solteras disminuyeron. La escolaridad de la madre y la cobertura de atención prenatal aumentaron. La tasa de restricción del crecimiento intrauterino (RCIU) se redujo de un 13,3% a un 10,6% (p < 0,001). La tasa de mortalidad perinatal disminuyó de 36,6 a 20,7 por mil (p < 0,001), y la tasa de mortalidad infantil (TMI) se redujo de 28,5 a 12,8 por mil (p < 0,001). La tasa de cesárea (TC) aumentó de 34,1% a 47,5% (p < 0,001). A pesar de los cambios favorables en factores sociodemográficos, de conducta y de servicios de salud, y de la reducción de RCIU, mortalidad perinatal e infantil, las tasas de BPN y el PTB se mantuvieron estables, mientras que la TC aumentó.

Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:56:55Z No. of bitstreams: 1 S0102-311X2001000600038.pdf: 36305 bytes, checksum: 0402e38950f904bc754d3296754db2fc (MD5) Made available in DSpace on 2013-08-22T18:56:55Z (GMT). No. of bitstreams: 1 S0102-311X2001000600038.pdf: 36305 bytes, checksum: 0402e38950f904bc754d3296754db2fc (MD5) Previous issue date: 2001-12-01 Made available in DSpace on 2013-09-30T19:51:13Z (GMT). No. of bitstreams: 2 S0102-311X2001000600038.pdf: 36305 bytes, checksum: 0402e38950f904bc754d3296754db2fc (MD5) S0102-311X2001000600038.pdf.txt: 26368 bytes, checksum: 95bcaa66b317b52434083b1a1eb5cebb (MD5) Previous issue date: 2001-12-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:13:17Z No. of bitstreams: 2 S0102-311X2001000600038.pdf: 36305 bytes, checksum: 0402e38950f904bc754d3296754db2fc (MD5) S0102-311X2001000600038.pdf.txt: 26368 bytes, checksum: 95bcaa66b317b52434083b1a1eb5cebb (MD5) Made available in DSpace on 2014-05-20T15:13:17Z (GMT). No. of bitstreams: 2 S0102-311X2001000600038.pdf: 36305 bytes, checksum: 0402e38950f904bc754d3296754db2fc (MD5) S0102-311X2001000600038.pdf.txt: 26368 bytes, checksum: 95bcaa66b317b52434083b1a1eb5cebb (MD5) Previous issue date: 2001-12-01 Agressões de morcegos a pessoas vêm sendo notificadas em várias comunidades amazônicas nesta última década. Isto constitui um risco potencial para a raiva humana transmitida por morcegos. O objetivo deste estudo foi de analisar fatores associados a estas agressões em uma destas comunidades. Foi realizado um estudo transversal em um povoado de garimpeiros na Região Amazônica brasileira (160 habitantes). Foi realizada a captura de morcegos junto às casas e foram enviadas amostras para o laboratório. Das 129 pessoas entrevistas, 41% foram agredidas por morcegos pelo menos uma vez, com 92% das mordidas localizadas nos dedos dos pés. Por meio de regressão logística, encontrou-se que adultos eram agredidos ao redor de quatro vezes mais do que crianças (OR = 3,75, IC: 1,46-9,62, p = 0,036). Homens foram agredidos com maior freqüência do que mulheres (OR = 2,08, IC: 0,90-4,76, p = 0,067). Nove Desmodus rotundus e três morcegos frugívoros foram capturados e resultaram negativos para a raiva. O estudo sugere que, em áreas de garimpo, adultos do sexo masculino têm maior probabilidade de serem agredidos por morcegos. As ações de controle para a raiva humana a serem desenvolvidas nestes lugares devem dar ênfase especial a adultos homens. Recomendam-se mais investigações sobre o modo como o garimpo na Região Amazônica está colocando em risco as pessoas e o ambiente. Many people in Amazonian communities have reported bat bites in the last decade. Bites by vampire bats can potentially transmit rabies to humans. The objective of this study was to analyze factors associated with bat biting in one of these communities. A cross-sectional survey was conducted in a village of gold miners in the Amazonian region of Brazil (160 inhabitants). Bats were captured near people's houses and sent to a lab. of 129 people interviewed, 41% had been attacked by a bat at least once, with 92% of the bites located on the lower limbs. A logistic regression found that adults were bitten around four times more often than children (OR = 3.75, CI 95%: 1.46-9.62, p = 0.036). Males were bitten more frequently than females (OR = 2.08, CI 95%: 0.90-4.76, p = 0.067). Nine Desmodus rotundus and three frugivorous bats were captured and tested negative for rabies. The study suggests that, in an area of gold miners, common vampire bats are more likely to attack adults and males. The control strategy for human rabies developed in this region should therefore place special emphasis on adult males. There should also be more research on how the search for gold in the Amazonian region places people and the environment at risk. Pan American Health Organization Science Communication Studies Instituto de Salud Ambiente y Trabajo Universidade Estadual Paulista Instituto de Biociências Departamento de Zoologia Universidad Nacional Autonóma de México Universidade Estadual Paulista Instituto de Biociências Departamento de Zoologia

This study analyzes the prevalence of illicit drug use and associated factors during pregnancy. This was a cross-sectional study of participants in the BRISA prenatal care cohort. Frequencies and hierarchical logistic regression were used. Estimated prevalence rates were 1.45% for illicit drug use, 22.32% for alcohol consumption, and 4.22% for smoking. The study population was mostly young (81% in the 20-34-year bracket), with 9 to 11 years of schooling (75.55%), with more than half of the women outside the workforce (52.18%), and in economic class "C" (67.61%). Pregnant women showed a high level of stress (24.46%), moderate to intense anxiety (40.84%), and severe depressive symptoms (28.8%). Approximately half (49.72%) of the pregnant women reported some type of violence, and they had wide networks (72.77%) and low social support (65.21%). Use of legal drugs, high stress levels, and single parenthood were independently associated with illicit drug use in pregnancy.