1. Lack of Association between Monocyte Chemoattractant Protein-1 (MCP-1) Gene Promoter Polymorphism and Behcet’s Disease with and without Ocular Involvement in Iranian Population: A Case–Control Study
- Author
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Maryam Ghaffari Laleh, Mehdi Yaseri, Mohammad Hossein Jabbarpoor Bonyadi, Elham Shahriyari, Masoud Soheilian, and Mortaza Bonyadi
- Subjects
medicine.medical_specialty ,Genotype ,Behcet's disease ,Disease ,Iran ,Polymorphism, Single Nucleotide ,Gastroenterology ,Cellular and Molecular Neuroscience ,Gene Frequency ,Polymorphism (computer science) ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Allele frequency ,Chemokine CCL2 ,business.industry ,Behcet Syndrome ,Case-control study ,Promoter ,Odds ratio ,medicine.disease ,eye diseases ,Sensory Systems ,Ophthalmology ,Case-Control Studies ,business - Abstract
PURPOSE This case-control study aimed to evaluate the possible association of MCP-1 - 2518A/G genetic polymorphism with Behcet's disease (BD) in the Iranian patients. MATERIALS AND METHODS This study was performed in 135 Behcet's patients (51 ocular and 84 non-ocular) and 79 healthy individuals. Peripheral blood samples were genotyped for MCP-1 - 2518A/G using the PCR-RFLP technique. RESULTS The statistical analysis of MCP-1 - 2518A/G showed no significant differences in genotype/allele frequencies between Behcet's patients and controls. There was no significant association in genotype/allele frequencies between either ocular or non-ocular BD patients and controls. Also, different genotype/allele frequencies between ocular and non-ocular BD were not statistically significant. CONCLUSIONS In this study, with a threshold P-value of 0.05 and an estimated power of 0.81 to detect a significant association (odds ratio ≥1.2), we did not observe any association of this variant with Behcet's disease.
- Published
- 2021